Gene CDC14B in Homo sapiens

Synonym: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, RP11-172F4.1, CDC14B

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP006_AA protein Get Run
HsapP006_AA_46-194 phosphatase_domain Get Run
HsapP006_AA_213-371 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 48-372 2.8e-175 576.9 In-house 3-328 (328) alignment 
Range on Protein: 48-372
Range on HMM: 3-328/328.0
VYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRT
..  ..|||.||.|...|||.|..||||.|.||.||||||||||||||..||||.|.||||||... .||||..|..|..|.||||.|.|.|.|||| .|
alelledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkkt

PEEAYRILIFGET-SYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPE
.|||||.| ..|| ...|||||.|||.....||||....|.||.|.|||....|.|.|||.||..||||.|||.||.|.|..|||....||.||..|.||
aeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaPe

TYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRI
....||...||||..||||..||||.||||||||.||||.|||||.|||||.||.|.|.|||||||||||||||||||||||.|||||.||||.|||.||
klleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlri

CRPGSVIGPQQQFLVMKQTNLWLEGD
|||||||||||.||..||..||||||
crPGsvigpqqkfleekqaalwlegd
DSPn Dual specificity protein phosphatase, N-terminal half 52-189 3.6e-58 186.3 Pfam-A 4-141 (141) alignment 
Range on Protein: 52-189
Range on HMM: 4-141/141.0
ITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEA
| |||.|..| ..||. .|.||||||.||.||.|||||||||||..||.|.|.|||||. .. .||||..|..|..|.||||.|.|.|.||.|...||||
iedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeea

YRILIFGETSYIPFRDAAYGSCNFYITLLDCFHAVKKA
.. |  .|.|..|||||.||......|.|||.....||
lkplesvepsllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 45-198 3.3e-56 183.7 In-house 4-157 (157) alignment 
Range on Protein: 45-198
Range on HMM: 4-157/157.0
QDDVYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYL
. |....|.|||.||.|.. |||  |..|||||..| ||.|..||||||||..||...|.||.||.... .|.|....  ...|....|.|.|||....|
ngdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl

GRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFN
| |||||...| . . ...||||| |. .....||||..... ||...|||...
gftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle
0041856 (Phosphotyrosine protein) phosphatases II 199-375 7.8e-49 161.0 In-house 1-177 (182) alignment 
Range on Protein: 199-375
Range on HMM: 1-177/182.0
SFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKE
......|...   ...  .. | ....... |..|  .  |....... .....|....|||..|. ..|........|. ...|.. |...|.  .. .
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelld

FLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFR
|...... .|...|||.||.||||||.|.|.||...... |....|| .|||.|| |.| |... .  ..|.....|
fieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
0038934 (Phosphotyrosine protein) phosphatases II 203-361 2.6e-46 153.0 In-house 4-169 (194) alignment 
Range on Protein: 203-361
Range on HMM: 4-169/194.0
DEYEHYEKAENgdlnwIIPDRFIAFCGPHSRA--RLESGYHQHSPETYIQYFKNH--NVTTIIRLN--KRMYDAKRFTDAGFDHHDLFFAD-GSTPTDAI
|....||. ..     ||..|||||..|.|    .  ......|||....|.| .  .....|.|.  .|.||...|..||.....|.| | |..|...|
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VKEFLDIC-----ENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLV
...|||..     |...|..||||||||||||||.|.|......|.| | ||..|..|||... ...   .
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
0049772 (Phosphotyrosine protein) phosphatases II 162-367 2.6e-45 150.9 In-house 66-270 (314) alignment 
Range on Protein: 162-367
Range on HMM: 66-270/314.0
YIPFRDAAYGSCNFYITLLDCFHAVKKaMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDR---------------------FIAFCGPHsrarlesgy
. |... .| ....  . |.. .. .. ..... .|..... .|....  ..||||....                       .. ..|..         
glpvsgsdyinasyvdgflkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.........

hQHSPETYIQYFKnhnvttiirlnKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICEN--AEGAIAVHCKAGLGRTGT-LIACYIMKHYRMTA
  . .. .....|           ...||...|...|. .... . |||.|......|||...|.  ..|...|||||| ||||| ..|.|.||......
.neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

AETIAWVRICRPgsvIGPQQQFLVMKQTNL
.|....|| .||   |.|.. |. . .  .
eealedvrlkRp...inpnpgfieqleqye
0045450 (Phosphotyrosine protein) phosphatases II 159-363 1.3e-43 145.3 In-house 2-298 (307) alignment 
Range on Protein: 159-363
Range on HMM: 2-298/307.0
ETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQyGFLNFNSFNLDEYEHYEKAENGDLNWI---------------------------------------
......|.|| .. . ....|||... ..|...  .|... | |.||..... ||.|.|..                                       
dlplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplllll

----IPDRFIAFCGPHSRarlesgyhqhSPETYIQYFKNHNVTTIIRLNKRMYDAKR------------------------------------------F
    ....|||. ||..           ..| .........||.|..|.. ......                                          .
dgydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldg

TDAGFDHHDLFF---ADGSTPTD-AIVKEFLDICEN------AEGAIAVHCKAGLGRTGTLIACYIMKHYR--------MTAAETIAWVRICRPGSVIGP
|. .. .. ...    |...|.. ... .|......       .| ..|||.||.|||||.||.|.|....        ... |.....| .|||.|  |
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

QQQFLVMK
.|   ...
eqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 153-363 1.4e-43 144.8 In-house 2-293 (308) alignment 
Range on Protein: 153-363
Range on HMM: 2-293/308.0
RILIFGETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLN------FNSFNLDEYEHYEKAENGDLNW----------------------------
....  ......|||. .  .......||. ....||...|.|.      .. ..| ||..... ||.|.|.                            
llildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdg

---IIPDRFIAFCGPHsrarlesgyhQHSPETYIQYFKNHNVTTIIRLNKRMYD-----AKRFTDA---GFDHHDLFF----------------------
   ..| .|||. ||.          ... | ..... ..||..|..|.| ...     |. . .    |. ... |.                      
yssklprkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnl

----------------ADGSTPTD-AIVKEFLDICENA--EGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLV
                 |...|.. .|. .||.....   .| |.|||.||.|||||.||....     |...... |.....| .|||.|..|.| ...
gdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

MK
..
yr
0040438 (Phosphotyrosine protein) phosphatases II 172-364 2e-43 144.2 In-house 2-271 (317) alignment 
Range on Protein: 172-364
Range on HMM: 2-271/317.0
SCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWII----------------------------------PDRFIAFCGPHsrarle
 .... .|||...  ..|.. .| .. |..||.|...|. ||.|.|..                                   ...|||. ||.      
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl......

sgyhQHSPETYIQYFKNHNVTTIIRLNKRMYD------------------------AKRFTDAGFDHHDLFF-------------------ADGSTP-TD
    ... | .........||.|..|.. ...                         . ...||. .. | .                    |...| . 
....pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppsp

AIVKEFLDICENA----EGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQ
 .. .||.....|    .| ..|||.||.|||||.||.|.|     |...... |.....| .|||.|  |.|   ... 
dllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0048567 (Phosphotyrosine protein) phosphatases II 212-369 3.6e-42 138.2 In-house 3-139 (157) alignment 
Range on Protein: 212-369
Range on HMM: 3-139/157.0
ENGDLNWIIPDRFIAFCGPHSRArlesgyhqhspetyiqyfknhnvttiirlnkRMYDAKRF-TDAGFDHHDLFFADGstPTD--------AIVKEFLDI
|||||..|||||......|. .                                ..|.|. | .|.|. ..|.|| .|  | .         ....||.|
engdlieiipdrlyfallprlpk...............................slynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflki

CENAEGAIAVHCKAGL---GRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWL
.|.|..||||||||||   |||.|||.||...|...|..|.||..||.|||||.......|..... ..|
lelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltll
0043147 (Phosphotyrosine protein) phosphatases II 203-362 6.6e-42 138.5 In-house 2-154 (172) alignment 
Range on Protein: 203-362
Range on HMM: 2-154/172.0
DEYEHYEKAENGDLNWiIPDRFIAFCGPhsrarlesgyHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDI
||...|. |.. ||.. |||||||..||           ..  . .....|....|.|..|....||.. ... |. .. | . |...|. ... |||..
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflef

CEN-----AEGAIAVHCKAGLGRTGTLIACYIMKhYRMTAAETIAWVRICRPGSVIGPQQQFLVM
...      .|...|||.||.||||||.|.|.|. ..... |..|.|| .|||.|  |.|. ...
idellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfly
0039614 (Phosphotyrosine protein) phosphatases II 162-362 2.6e-41 137.4 In-house 1-282 (297) alignment 
Range on Protein: 162-362
Range on HMM: 1-282/297.0
YIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNL----DEYEHYEKAENGDLNWII------------------------------------P
|.|.|||...|. .... ||... ..||.. ..|  . ..|    ..|..... ||.|.|...                                    .
ylplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt

DRFIAFCGPHSRarlesgyhqhSPETYIQYFKNHNVTTIIRLNKRMYDAK----------------------RFTDAGFD-----------------HHD
..|||. ||..           ..| .........||.|..|.| ... .                       ....|.                  .. 
rkfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqy

LFFADGSTP-TDAIVKEFLDICEN------AEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLVM
. . |...| . ... |||.....       .| ..|||.||.|||||.||.|.|     |...... |.....| .|||.|  |.|   ..
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly
0045098 (Phosphotyrosine protein) phosphatases II 182-369 3e-41 137.0 In-house 2-273 (278) alignment 
Range on Protein: 182-369
Range on HMM: 2-273/278.0
CFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWII----------------------PDRFIAFCGPHSrarlesgyhqHSPETYIQYFKNHNVTT
. .|. ....... ..  .. .|.... . .|.|.|..                       |..|||. ||.           .  . ..........|.
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitv

IIRLNKRMYDA----------------------------------------------KRFTDAGFDHHDL-FFADGSTPTDAIVKEFLDICE--------
|..|.. ....                                              . .. .|. |... .. |...|.. |.| ||...|        
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

------------NAEGAIAVHCKAGLGRTGTLIACYIMKHY---RMTAAETIAWVRICRPG-SV-IGPQQQFLVMKQTNLWL
            . .| ..|||.||.||||||.|.|.|...   .... |.....| .||| .| .  |..|| . .  |.|
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0043336 (Phosphotyrosine protein) phosphatases II 171-361 3.1e-41 137.1 In-house 3-269 (278) alignment 
Range on Protein: 171-361
Range on HMM: 3-269/278.0
GSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWII----------------------------------PDRFIAFCGPHSRarl
. .... .||... ..|.... .| ...||.||.|..... ||.|.|..                                   |..|||. ||..    
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

esgyhqhSPETYIQYFKNHNVTTIIRLNKRM--------------------------------------------YDAKRFTDAGFDHHDLFfaDGSTPT
       ..| .........||||..|.. .                                            .| . .|  .. ...    |...|.
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpe

D-----AIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLV
.      ..|......|. .|...|||.||.|||||.||.|..     |...... |.....| .|||.|  |.|   .
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 196-373 5.4e-40 132.3 In-house 3-176 (178) alignment 
Range on Protein: 196-373
Range on HMM: 3-176/178.0
NFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPhsrarlesgyhqhspETYIQYFKNHNVTTIIRLNKRMY------DAKRFTDAGFDHHDLFFADGS
 .. ..|...|..| ... ....|.|. ... ..|               . .....|....|.|..|.. ..      |.. ...||. .. . . |..
drtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhg

TPT-DAIVKEFLDICE----NAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDY
.|. .... ||....|    . .|...|||.||.||.|||.|.|.||...... | |..|| .||..    |...| . .  |. |.|.
vpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesdl
0049260 (Phosphotyrosine protein) phosphatases II 225-364 3.5e-37 122.8 In-house 2-145 (152) alignment 
Range on Protein: 225-364
Range on HMM: 2-145/152.0
IAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDI-----CENAEGAIAVHCKAGLG
| ..... ..    |.  .. . .....|....|||..|.......| ... .. .. |.. |...|..... .|| .     ... .| ..|||.||.|
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RTGTLIACYIMKhYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQ
|||||.|.|.|. ..... |..|.|| .|||.|. |.| ..... 
Rtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyef
0036282 (Phosphotyrosine protein) phosphatases II 207-362 2.1e-35 117.4 In-house 3-163 (174) alignment 
Range on Protein: 207-362
Range on HMM: 3-163/174.0
HYEKAENGDLNWIIPdRFIAFCGPHSrarlesgyhqhspetYIQYFKNHNVTTIIRLNKRMYDA------------KRFTDAGFDHHDLFFADGSTPTDA
.|..| . ||..| | |.||..||..               .....|....||...|.. ...             . ... |. ...| . |...|...
dyinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdls

IVKEFLDICENA-----EGAIAVHCKAGLGRTGTLIACYIMKHYRM-TAAETIAWVRICR---PGSVIGPQQQFLVM
|. ||....|.|     .| ..|||.||.||||||.|.|.|... . .. . ...|| .|   ||.|. |.|   . 
illefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0040439 (Phosphotyrosine protein) phosphatases II 204-362 3.1e-35 117.4 In-house 2-239 (249) alignment 
Range on Protein: 204-362
Range on HMM: 2-239/249.0
EYEHYEKAENGDLNWII----------------------------------PDRFIAFCGPHSRarlesgyhqhSPETYIQYFKNHNVTTIIRLNKRM--
||..... ||.|.|..                                   ..||||. || .           . | ..........|.|..|.. .  
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDAKRFTDAGFDHHDLFfaDGSTP-TDAIVKEFLDICEN------AEGAIAVHCKAG
                                           || . .|  .. ..|.   | ..| . ... .|......       .| ..|||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLVM
.|||||.||.|.|     |...... |.....| .|||.|  |.|   ..
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly
0037934 (Phosphotyrosine protein) phosphatases II 210-362 3.8e-35 117.0 In-house 33-235 (243) alignment 
Range on Protein: 210-362
Range on HMM: 33-235/243.0
KAENGDLNWIIPdRFIAFCGPHSRarlesgYHQHSPETYIQYFKNHNVTTIIRLNKRM------------------------------------------
   |..| .. | |.||..||..        ... .............|.|. |.. .                                          
dyinanliyvtp.rliatqgPlpe......tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

YDAKRFTDAGFDHHDLFFADGSTPT-DAIVKEFLDI------------CENAEGAIAVHCKAGLGRTGTLIACYIMKHY-RMTAAETIAWVRICRPG-SV
.|.. .|  .. .| | . |...|.  ... .|||.            ... .| ..|||.||.||||||||.|.|... .... |.....| .||| .|
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkav

IGPQQQFLVM
  |.|   ..
qtpsqyrfly
0042113 (Phosphotyrosine protein) phosphatases II 205-362 4.7e-35 116.6 In-house 1-236 (245) alignment 
Range on Protein: 205-362
Range on HMM: 1-236/245.0
YEHYEKAENGDLNWI----------------------------------IPDRFIAFCGPHSRarlesgyhqhSPETYIQYFKNHNVTTIIRLNKRMYD-
|..... ||.|.|..                                  |...|||. ||..           ..| ..........|||..|.. ... 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------AKRFTDAGFDHHDLFFADGSTPT-DAIVKEFLDICEN-----AEGAIAVHCKAGLGRT
                                           . ..  .. .| | . |...|. .... .||.....     ..| ..|||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLVM
||.||.|.|     |...... |.....| .|||.|  |.|   ..
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 212-366 8.8e-35 115.4 In-house 8-170 (176) alignment 
Range on Protein: 212-366
Range on HMM: 8-170/176.0
ENGDLNWIIPDRFIAFCgphsrARLESGYHQHSPETYIQYFKNHNVTTIIRLNKR--------MYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDIC
...||..|... ..  .          | . .. .......|....|....|...        ... ......|. .. | . |...|..... |.|...
ldldldyinanlilgsr.....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefi

ENAE---GAIAVHCKAGLGRTGTLIACYIMKH-YRMTAAETIAWVRICRP-GSVIGPQQQFLVMKQTN
..|    | ..|||.||.||||||.|.|.... . ... |..|.|| .|| |.|  |.|   ...   
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 215-363 1.6e-33 110.8 In-house 7-147 (151) alignment 
Range on Protein: 215-363
Range on HMM: 7-147/151.0
DLNWIIPDrFIAFCGPHSrarlesgyhqhspeTYIQYFKNHNVTTIIRLNKRM---YDAKRFTDAGFDHHDLFFADGSTPTD----AIVKEFLDICENA-
..... .  .... ||..               .....|.....||. |.. .   |........|...... . | ..|.     ..|.|||.....  
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

EGAIAVHCKAGLGRTGTLIACYIMKhYRMTAAETIAWVRICRPGSVIGPQQQFLVMK
.| ..|||.||.||||||.|.|.|. ......|.....|..|||.|. .||......
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
PTEN_1 209-364 9.8e-32 105.3 In-house 18-188 (196) alignment 
Range on Protein: 209-364
Range on HMM: 18-188/196.0
EKAENGDLNWIIPDRFIAFCGP-HSrARLESGYHQ--HSPETYIQYFKNHNVTTIIRLNK------RMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEF
|.....  .. | . . |.. | ..    |. | .  .... . . .| ...|....|.       | || . | . |. .... . |  .|. . . ..
elldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdi

LDICENA------EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICR-PGSVIGPQQQFLVMKQ
.. ....      .....|||||||||.||..|.| |.....|| |....||..| ||..  |.|. |.  .
cksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
0047943 (Phosphotyrosine protein) phosphatases II 190-362 2.5e-31 104.6 In-house 16-265 (273) alignment 
Range on Protein: 190-362
Range on HMM: 16-265/273.0
MQYGFLnFNSFNLDEYEHYEKAENGDLNWI------------------------------IPDRFIAFCGPHsrarlesgyhQHSPETYIQYFKNHNVTT
...  | .. ..| .|..... ||.|.|..                              .. .|||. ||           ... | ........||..
eefell.lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl..........pntvedfwrmvweqnvrv

IIRLNKRMYDAKR-----FTD----------------------AGFD-------------------HHDLFFADGSTP-TDAIVKEFLDICEN------A
|..|.. ... ..     . .                      ...                    .| . . | ..| . ... ||......       
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

EGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQFLVM
.| ..|||.||.|||||.||....     |...... |.....| .|||.|. |.|  ...
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0048179 (Phosphotyrosine protein) phosphatases II 248-362 2.1e-30 100.7 In-house 21-138 (144) alignment 
Range on Protein: 248-362
Range on HMM: 21-138/144.0
YIQYFKNHNVTTIIRLNKRmYDAKRFTDAGFDHHDLFFADGSTPTD-AIVKEFLDICENA---EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAW
 ....|....||.|.|.   |.   ... |. .. | . | ..|.. ... |||...|.|   .| ..|||.||.||||||.|.|.||...... |..|.
dlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal

VRICRPGSVIGPQQQFLVM
|| .|||.|. |.|   ..
vrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 249-363 8.9e-30 98.6 In-house 22-137 (145) alignment 
Range on Protein: 249-363
Range on HMM: 22-137/145.0
IQYFKNHNVTTIIRLnkrMYDAKRFTDAGFDHHDLFFADGSTPTD-AIVKEFLDICENA---EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWV
....|....||...|   ... . ... |. .. | . | ..|.. ... |||...|.|   .| ..|||.||.||||||.|.|.|....... |....|
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RICRPGSVIGPQQQFLVMK
| .|||.|. |.|.  ...
rsqrpgavpnpgqlrflye
0046845 (Phosphotyrosine protein) phosphatases II 205-363 4.3e-25 84.1 In-house 20-268 (284) alignment 
Range on Protein: 205-363
Range on HMM: 20-268/284.0
YEHYEKAENGDLNW----------------------------------------IIPDRFIAFCGPHsrarlesgyhQHSPETYIQYFKNHNVTTIIRLN
.... . || ..|                                         .|. .|||. ||           ... | . .   ..||..|. |.
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl..........pntvedFwrmvweqnvrvIVmlt

KRMY-----------------------------------------------DAKRFTDAGFDHHDLFfaDGSTPT-DAIVKEFLDICENA------EGAI
. .                                                . . .|   | ...    | ..|.  ... |||......      .| |
elvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpi

AVHCKAGLGRTGTLIACYIMKHY--------RMTAAETIAWVRICRPGSVIGPQQQFLVMK
.|||.||.|||||.||.......        .... |.....| .|||.|  ..|  .| .
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
0051299 (Phosphotyrosine protein) phosphatases II 219-362 3.2e-24 81.3 In-house 89-279 (288) alignment 
Range on Protein: 219-362
Range on HMM: 89-279/288.0
IIPDRFIAFCGPHSrarlesgyhqHSPETYIQYFKNHNVTTIIRLNKRM-------------------------------------------------YD
 .. .|||. || .          .. | . ..  ..||..|..|.| .                                                 .|
nlkrkfIatqgPlp..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgd

AKRFTDAGFDHHDLFfaDGSTPT-----DAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIGPQQQF
 . .|   | ...    | ..|.      ...... . ... .| ..|||.||.|||||.||....     |...... |.....| .|||.|. |.|  
gesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr

LVM
.| 
fvy
0036941 (Phosphotyrosine protein) phosphatases II 197-363 6.5e-23 76.9 In-house 23-271 (297) alignment 
Range on Protein: 197-363
Range on HMM: 23-271/297.0
FNSFNLDEYEHYEKAENGDLNWIIPdrfiAFCGPHSRARLESGYHQHSPETYIQYFK------------------------NHNVTTIIRLNKRMYDAK-
.. ..| ....... || ..|         .. .|.| .|... .      |.. ..                        ..|||.|. |.. . . . 
lpllllgslsvallpenleknRykd....ilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

--------------------------------RFTDAGFD--------------HHDLFFADGSTPT-DAIVKEFLDICEN------AEGAIAVHCKAGL
                                 .|   .               .| .   | ..|.  |.. .|.. ...       .| . |||.||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGTLIACYIM--------KHYRMTAAETIAWVRICRPGSVIGPQQQFLVMK
||.||.||...|        |.....  |.. ..| .|||.|  ..|   .  
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye
subfamily_PRL_pd Subfamily PRL 245-361 4.6e-22 72.7 In-house 23-143 (151) alignment 
Range on Protein: 245-361
Range on HMM: 23-143/151.0
PETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDIC-----ENAEGAIAVHCKAGLGRTGTLIACYIMKHyRMTAAE
 |..|. .|...|.|..|  .  ||.. . ..| . .|| |.||..|....|.|.|...     |... ..|||| |||||.  |.|  .. .  |.  .
lekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyed

TIAWVRICRPGSVIGPQQQFLV
.. ..|  | |..   | .|| 
avefirekrrgainskqlkfle
0051429 (Phosphotyrosine protein) phosphatases II 245-364 6.1e-22 74.0 In-house 34-220 (272) alignment 
Range on Protein: 245-364
Range on HMM: 34-220/272.0
PETYIQYFKNHNVTTIIRLNKRMYDAK---RFTDAGFDHHDLFFADGSTPTD------------------------------------------------
 .  ....|.....||. | . .. ..    .  .|.... | . | |.||                                                 
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

----AIVKEFLDICENaEGAIAVHCKAGLGRTGTLIACYIMKhYRMT--------------AAETIAWVRICRPGSVIGPQQQFLVMKQ
      ..|.|... . .|.. |||.|| .||||..|....  ....              ..|.....| .|||.|  ..|   ... 
gvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_DSP23_pd Subfamily DSP23 244-363 5e-21 69.9 In-house 20-140 (148) alignment 
Range on Protein: 244-363
Range on HMM: 20-140/148.0
SPETYiQYFKNHNVTTIIRLNKRMYDAKRFTdAGFDHHDLFFADGSTPTDAIVKEFLDICENAE---GAIAVHCKAGLGRTGTLIACYIMKHYRMTAAET
.|. | .|. .  |  .. | ..       |  .   . |   |   |.   |.||. . |.||    |..|||  | |||||..|||..|. ...|||.
lpdqy.rylldlgvrylvslteegrphveat.pnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaea

IAWVRICRPGSVIGPQQQFLVMK
|| ||  |||||   .|. ||..
iaevrrlrpgsvetveqeklvrd
subfamily_PTPDC1_pd Subfamily PTPDC1 268-368 6.5e-18 59.8 In-house 73-174 (182) alignment 
Range on Protein: 268-368
Range on HMM: 73-174/182.0
YDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENA--EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIgPQQQFLVMKQT
|| . ....|  .. . ..| ....   . .   . . |  ||..|||| ||||||| |||||.. . |.||...|  ||  || |.  ...|  ..|. 
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiq.treqvelvkef

NLW
.|.
alf
PTPc_motif_SM00404 250-360 3.9e-17 57.5 In-house 21-131 (140) alignment 
Range on Protein: 250-360
Range on HMM: 21-131/140.0
QYFKNHNVTTIIRLNKRM---YDAKRFTDAGFDHHDlFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRI
.  |....|..| . . .   .  ..|.    ...|    |  ..    |..|.. .|. .|.. |||.||. |..|||..|.|. . ...|| .  |. 
allkklgithvinvteevsltkensgfqilqipldd.nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvke

CRpgSVIGPQQQFL
 |  . | |. .|.
rR..piispnlnfv
DSPc Dual specificity phosphatase, catalytic domain 250-360 4.9e-17 57.1 Pfam-A 12-124 (133) alignment 
Range on Protein: 250-360
Range on HMM: 12-124/133.0
QYFKNHNVTTIIRLNK-----RMYDAKRFTDAGFDHHDlFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWV
.  .....| .| . |     ...  ..... .   .| .  .  ..    ..||.. .|. .. ..|||.||. |..|||..|.|| ..... | .. |
alleklgitlvinvtkevpnnnaikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

RICRpgSVIGPQQQFL
.  |  | | |. .||
kerr..skispnagfl
DSPc Dual specificity phosphatase, catalytic domain 250-360 4.9e-17 57.1 In-house 12-124 (133) alignment 
Range on Protein: 250-360
Range on HMM: 12-124/133.0
QYFKNHNVTTIIRLNK-----RMYDAKRFTDAGFDHHDlFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWV
.  .....| .| . |     ...  ..... .   .| .  .  ..    ..||.. .|. .. ..|||.||. |..|||..|.|| ..... | .. |
alleklgitlvinvtkevpnnnaikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

RICRpgSVIGPQQQFL
.  |  | | |. .||
kerr..skispnagfl
subfamily_RNGTT_pd Subfamily RNGTT 219-350 6.8e-15 49.2 In-house 13-156 (189) alignment 
Range on Protein: 219-350
Range on HMM: 13-156/189.0
IIPDRFIAFCGPHSRARLE--SGYHQHSPETYIQYFK--NHNVTTIIRLN--KRMYDAKRFTDAGFDHHDLFFA-DGSTPTDAIVKEFLDICEN-----A
.| ..|..|  | |.   .  .  ....|.  ..|.|  ....  .| |   .|.||.. ... |  .. |  |  | .|.   ||||  ..|.     .
liaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknp

EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPG
|  |.|||. |  ||| ||..|....  . . . .|  . .|| 
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp
subfamily_DSP1_pd Subfamily DSP1 250-360 2.1e-12 41.4 In-house 37-146 (163) alignment 
Range on Protein: 250-360
Range on HMM: 37-146/163.0
QYFKNHNVTTIIRLNKRMYDAkrFTDaGFDHHDLFFADGSTPT----DAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVR
.  |....| |. . |.. ..  | |  | .. |   | ..         | ||.| .....| . .||.||. |  ||.  |.||. |..  |   .|.
eiLkslgitailnvskeldnv..fed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvk

ICRpgSVIGPQQQFL
  |  |.| |   | 
qrR..siisPnagFv
subfamily_PTPMT1_pd Subfamily PTPMT1 254-358 2.6e-12 41.5 In-house 44-158 (171) alignment 
Range on Protein: 254-358
Range on HMM: 44-158/171.0
NHNVTTIIRLNKR------MYDAKRFTDAGFDHHDLFFADGS-TPTDAIVK---EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAW
..|| ... ||.       .   ....  | ..  |   |   .|. . ..   ||..   .    . |||||| ||..||.|||.||.....  | .  
kenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlka

VRICRPGSVIGPQQQ
.. .|.   .  .|.
lkkkRkiirlakkqw
subfamily_DSP11_pd Subfamily DSP11 222-348 3.3e-12 40.7 In-house 18-157 (178) alignment 
Range on Protein: 222-348
Range on HMM: 18-157/178.0
DRFIAFCGPHSRArLESGY---HQHSPETYIQYFKN--HNVTTIIRLN--KRMYDAKRFTDAGFDHHDLFFADGSTPTDAIV-------KEFLDICENAE
 |||||  | ..  ....    .. .|.. ..  ..  ...  .| |   .| |. | .|| |  .. |. .  ..|.. .|       ||||. ... .
trfiafktPlkes.fdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdnd

GAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICR
  |.|||  |. ||| ||  |....  . . . |     .|
kligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_PTEN_pd Subfamily PTEN 215-342 8.4e-12 40.4 In-house 21-150 (184) alignment 
Range on Protein: 215-342
Range on HMM: 21-150/184.0
DLNWIIpDRFIAFCGPHsrARLESGYHQHSPETYIQYFKNH-NVTTIIRL-NKRMYDAKRFTDAgfdHHDLFFADGSTPTDAIVKEFLDIC-----ENAE
|| .|  .. ||   |    .||. |  .  ...  . |.| .   |. |  .| ||.|.|..     . . | |  .|.  ...|...       |. .
Dlsyit.eniiamgyPa..eklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgr...vavypfdDhnppplelleeivediekwleedkk

GAIAVHCKAGLGRTGTLIACYIMKHYRMTAA-ETIA
  ..|||||| ||||.||..|..|.  .. | |...
nvvvvHCkaGkGRtGvlivayllkslllekaeeale
subfamily_DSP3_pd Subfamily DSP3 262-360 7.6e-11 35.9 In-house 52-147 (162) alignment 
Range on Protein: 262-360
Range on HMM: 52-147/162.0
RLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsvIGPQQQFL
  .. .|.   ..  |.. .| . .| |.  .  .|   .  .. || . |||..|. |  ||.  |.| . .||. | |  ||  |    |.| . ||
dtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe...ilPneGFl
subfamily_DSP10_pd Subfamily DSP10 298-360 1.4e-10 35.2 In-house 83-143 (159) alignment 
Range on Protein: 298-360
Range on HMM: 83-143/159.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsVIGPQQQFL
||..   . .  . |||.||. |  |..  |.||| ...  .   .|. .||  .| |  .|.
efieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfm
subfamily_DSP12_pd Subfamily DSP12 298-368 1.5e-10 35.7 In-house 73-139 (155) alignment 
Range on Protein: 298-368
Range on HMM: 73-139/155.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsVIGPQQQFlvMKQTNLW
.|.. . . |||. |||.||. |  |... |.||....   . .  |.  .|   | | . |  ..|  |.
dFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp..eiepNegF..leQLklf
subfamily_DSP19_pd Subfamily DSP19 253-359 2e-10 35.2 In-house 34-139 (152) alignment 
Range on Protein: 253-359
Range on HMM: 34-139/152.0
KNHNVTTIIRLNKRMYDA--KRFTDAGFDHHDLFFADGSTPTDAiVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPg
|....| |. .   . ..  | ||    .  ||  .| ..  .. . .|..   ...||. |||.||  |. ...  |.||. ...  |..  ||  || 
kekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylke.aldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp.

sVIGPQQQF
  | | . |
.cikPneGF
subfamily_DSP8_pd Subfamily DSP8 298-359 7.1e-10 32.7 In-house 84-143 (159) alignment 
Range on Protein: 298-359
Range on HMM: 84-143/159.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRpgSVIGPQQQF
||.| . ...| . ||. ||  |  |.. .||||. .|.  |.  .|.  |   .| |. .|
efidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnlnf
PTPc_DSPc_SM00012 296-358 1.9e-09 33.0 In-house 29-96 (105) alignment 
Range on Protein: 296-358
Range on HMM: 29-96/105.0
VKEFLDICENaEGAIAVHCKAGLGRTGTLIACYIMKHYRMTA------AETIAWVRICRPGSVIGPQQQ
||..   .|. .. . |||.|| |||||..| .|. .  ..        ...  .|  |||.|   .|.
vkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_DSP15_pd Subfamily DSP15 252-362 2.6e-09 31.3 In-house 23-131 (151) alignment 
Range on Protein: 252-362
Range on HMM: 23-131/151.0
FKNHNVTTIIRLNKrmyDAKRFTDAgFDHHDLFFADG-STPTDAIVKE---FLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRIC
 |..|.|.|. ..    .||.. .  .... .  .|  |.  . ..||   |.  |   |... ||| ||. |  ||.. |.|    .   ...  .. .
Lkeknithilsvhd...nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaa

RpgSVIGPQQQFLVM
|  ||  |   |   
R..svanPnfGfkrq
subfamily_Slingshot_pd Subfamily Slingshot 298-360 4.2e-09 30.0 In-house 87-147 (169) alignment 
Range on Protein: 298-360
Range on HMM: 87-147/169.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRpgSVIGPQQQFL
.|.. . ...  . |||| |. |. . .  | ||.|...  |....|.  |  ||| | . ||
kfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgfl
subfamily_DSP14_pd Subfamily DSP14 301-359 4.2e-09 30.5 In-house 77-133 (157) alignment 
Range on Protein: 301-359
Range on HMM: 77-133/157.0
DICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsVIGPQQQF
.  ....|.. |||.||  |  .|   |.||. ... .|.  .|. .||  .| | . |
eevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirPNvGF
subfamily_CDKN3_pd Subfamily CDKN3 271-359 1.2e-08 28.8 In-house 93-185 (202) alignment 
Range on Protein: 271-359
Range on HMM: 93-185/202.0
KRFTDAGFDHHDLFFADGSTPTDAIVKEF---LDICENAEGAIAVHCKAGLGRTGTLIACYI-MKHYRMTAAETIAWVRICRPGSVIGPQQQF
. .. ||.  |   .||| .|  |   ..   | |. .|     |||  ||||.  .||| . . .  .   ..|. .|  .    |   .|.
dlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 291-358 1.6e-08 28.4 In-house 204-277 (302) alignment 
Range on Protein: 291-358
Range on HMM: 204-277/302.0
PTDA-IVKEFLDICENAEGAIAVHCKAGLGRTGTLIAC-YI----MKHYRMTAAETIAWVRICRPGSVIGPQQQ
| .|    . |  ||    .. ||| ||.||||||.|  |     .|.     .. .  || || |.|   || 
pkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_STYX_pd Subfamily STYX 295-347 2.1e-08 27.4 In-house 84-136 (166) alignment 
Range on Protein: 295-347
Range on HMM: 84-136/166.0
IVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRIC
 ||||.| . .  | . || .||. |. .|. .|||. | .   |. |.|.  
tvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqer
subfamily_DSP6_pd Subfamily DSP6 298-360 5.2e-08 26.6 In-house 84-144 (158) alignment 
Range on Protein: 298-360
Range on HMM: 84-144/158.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRpgSVIGPQQQFL
||.|   ... .. ||| ||. |. |.. .|.||.. ..  .. ..|.  .  | | |  .|.
efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrk..snisPnfnfm
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 298-362 9.3e-08 26.1 In-house 207-275 (290) alignment 
Range on Protein: 298-362
Range on HMM: 207-275/290.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYI-----MKHYRMTAAETIAWVRICRPGSVIGpQQQFLVM
  | |  .| | ..||| ||.|||||..|  .     ..   .  ....  .| .| .||   . |.|..
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqv.diqylal
PTPlike_phytase Inositol hexakisphosphate 253-330 1e-07 26.7 Pfam-A 71-147 (149) alignment 
Range on Protein: 253-330
Range on HMM: 71-147/149.0
KnhnVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAE--GAIAVHCKAGLGRTGTLIACYIM
.   . |.... ...|... ..  |.. . .   | . |... | .|........   |. ..|.|| ||| | .... .
v...qktltevteevyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslprdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 253-330 1e-07 26.7 In-house 71-147 (149) alignment 
Range on Protein: 253-330
Range on HMM: 71-147/149.0
KnhnVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAE--GAIAVHCKAGLGRTGTLIACYIM
.   . |.... ...|... ..  |.. . .   | . |... | .|........   |. ..|.|| ||| | .... .
v...qktltevteevyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslprdtalvfnCqaGrgRTTtamviadL
Y_phosphatase Protein-tyrosine phosphatase 295-354 1.7e-07 26.3 Pfam-A 155-222 (235) alignment 
Range on Protein: 295-354
Range on HMM: 155-222/235.0
IVkEFLDICENAE----GAIAVHCKAGLGRTGTLIACYIMKHYRMT-----AAETIAWVRICRPGSVIG
.. .... .|. .    | . |||.|| |||||..|  |. .   .       ...  .| .|||.|  
ll.dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 295-354 1.7e-07 26.3 In-house 155-222 (235) alignment 
Range on Protein: 295-354
Range on HMM: 155-222/235.0
IVkEFLDICENAE----GAIAVHCKAGLGRTGTLIACYIMKHYRMT-----AAETIAWVRICRPGSVIG
.. .... .|. .    | . |||.|| |||||..|  |. .   .       ...  .| .|||.|  
ll.dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 304-364 1.7e-07 24.7 In-house 88-144 (154) alignment 
Range on Protein: 304-364
Range on HMM: 88-144/154.0
ENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsVIGPQQQFLvmKQ
   .. . ||...|. |. .|.  |.|.. ...  ...  .. .|.  .| | | ||  ||
gvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsry..iikPnqGfl..kq
subfamily_LRR-DSP_pd Subfamily LRR-DSP 306-357 1.8e-07 24.5 In-house 196-245 (263) alignment 
Range on Protein: 306-357
Range on HMM: 196-245/263.0
AEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPgsVIGPQQ
 .| . |||.||. |. ||. .|.||. |..  |..  |   ||   | | .
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrp..riqPnp
DSPc_SM00195 303-360 2.9e-07 25.5 In-house 191-252 (263) alignment 
Range on Protein: 303-360
Range on HMM: 191-252/263.0
CENAEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIgPQQQFL
 .. .| | |||.||.|||||...  |.     .. ..   |..  .|  |||.|   ..|.|
kstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvq.tleqYl
PTPc_SM00194 303-360 2.9e-07 25.5 In-house 191-252 (263) alignment 
Range on Protein: 303-360
Range on HMM: 191-252/263.0
CENAEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPGSVIgPQQQFL
 .. .| | |||.||.|||||...  |.     .. ..   |..  .|  |||.|   ..|.|
kstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvq.tleqYl
subfamily_VSP_pd Subfamily VSP 265-340 3.4e-07 24.4 In-house 84-162 (212) alignment 
Range on Protein: 265-340
Range on HMM: 84-162/212.0
KRMYDAKRFTD----AGFDHHDLFFADGSTPTDAIVKEFLDicENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAA-ET
.| || | | .       | |..   .       .|||.|.  .. .  .|.||| | |||||.. .....   .. | |.
eraydekyfnnrvkriliddhnvpkleellvftkevkewle..kdlknvlaihckGGkgrtGtivcalllaseifetakes
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 287-333 7.2e-07 23.2 In-house 199-246 (305) alignment 
Range on Protein: 287-333
Range on HMM: 199-246/305.0
DGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIA-CYIMKHY
 |  ..|  . |.|  .  . | |.||| ||.||||...   ||..  
rgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildql
subfamily_PTPN6_pd Subfamily PTPN6 301-330 1.1e-06 22.9 In-house 221-250 (306) alignment 
Range on Protein: 301-330
Range on HMM: 221-250/306.0
DICENAEGAIAVHCKAGLGRTGTLIACYIM
.. |. .|.| ||| ||.|||||.|   |.
eleeaeagpivvhCsaGiGRtGtfiviDil
subfamily_PTPN13_pd Subfamily PTPN13 304-363 1.3e-06 22.9 In-house 199-262 (273) alignment 
Range on Protein: 304-363
Range on HMM: 199-262/273.0
ENAEGAIAVHCKAGLGRTGTLIACYIM-----KHYRMTAAETIAWVRICRPgSVIGPQQQFLVMK
.. .| |.||| ||.||.||||. ...     .   .   |..  .|  |  .|.  ..|.. . 
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrq.gvvqtkdqyifvy
subfamily_PTPRK_pd Subfamily PTPRK 292-332 2e-06 21.9 In-house 195-235 (314) alignment 
Range on Protein: 292-332
Range on HMM: 195-235/314.0
TDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKH
  ..|..     |. .| | ||| || ||||| ||. |.  
llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld
subfamily_STYXL1_pd Subfamily STYXL1 298-360 2e-06 21.1 In-house 83-143 (157) alignment 
Range on Protein: 298-360
Range on HMM: 83-143/157.0
EFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGsvIGPQQQFL
.|... .. . .. |  . |. |. ..|..|.| ....|  .. . .. |..   . |...|.
qfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCken..vkPnrafv
subfamily_PTPN12_pd Subfamily PTPN12 294-332 2.3e-06 21.7 In-house 194-232 (290) alignment 
Range on Protein: 294-332
Range on HMM: 194-232/290.0
AIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKH
...... .. |. .  ..||| || |||||.||  ....
elielvrelqesedaPlvvhCsaGvGrtGtiiaidyvre
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 250-360 2.5e-06 21.1 In-house 27-137 (148) alignment 
Range on Protein: 250-360
Range on HMM: 27-137/148.0
QYFKNHNVTTIIRLNKrmYDAKRFTDAGFDHHDLFFAD-GSTPTDAIVKEFLDICENA---EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVR
.  |. .|| |.  .|     . . . | .. ..  .|       || ... .  ..|    . . ||.. |  |   |   ..... |..  | .| |.
ealkalgvtrivnatk..erdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvk

ICRPGsvIGPQQQFL
  |..  . |.. ||
skrry..vdpnlgfL
subfamily_MSG5_pd Subfamily MSG5 307-338 2.6e-06 20.7 In-house 99-130 (165) alignment 
Range on Protein: 307-338
Range on HMM: 99-130/165.0
EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAA
.  | |||. || |. .||  ||||.| ..  
rkkilvhcqcglsrsaslivayimkyynlslr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 287-366 2.9e-06 21.5 In-house 172-261 (270) alignment 
Range on Protein: 287-366
Range on HMM: 172-261/270.0
DGSTPTDAIVKEFLDI---CENA---EgAIAVHCKAGLGRTGTLIAC-----YIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTN
|.|. || ..| . ..   ...    |  . ||| ||.||||||||       . .. ..  .. |. .|  |.  |  |.|  .. |   
dsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPRB_pd Subfamily PTPRB 304-333 3.8e-06 21.1 In-house 215-245 (293) alignment 
Range on Protein: 304-333
Range on HMM: 215-245/293.0
ENAEGAIAVHCKAGLGRTGTLIACY-IMKHY
..... | ||| ||.|||||.||   .... 
taskrPivvhCsaGvGRtGtfialdrllqai
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 300-334 3.9e-06 21.1 In-house 204-240 (288) alignment 
Range on Protein: 300-334
Range on HMM: 204-240/288.0
LDICENAE-GAIAVHCKAGLGRTGTLIACY-IMKHYR
... ..|. | | ||| ||.||||| ||   .... .
vkvanqadtgpiivhCsaGvGrtgtFialdalidave
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 295-334 4.3e-06 21.1 In-house 209-248 (325) alignment 
Range on Protein: 295-334
Range on HMM: 209-248/325.0
IVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYR
 |.| .    .| . | ||| ||.||||..|. | .    
avservtantkastpilvhcsaGvGrtGvfislysalakv
subfamily_PTPRA_pd Subfamily PTPRA 304-332 5.5e-06 20.5 In-house 225-253 (330) alignment 
Range on Protein: 304-332
Range on HMM: 225-253/330.0
ENAEGAIAVHCKAGLGRTGTLIACYIMKH
..  |.| ||| || |||||.|.   . .
qqsagpivvhcsaGvGrtGtfivldavle
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 296-346 7.4e-06 19.1 In-house 69-119 (145) alignment 
Range on Protein: 296-346
Range on HMM: 69-119/145.0
VKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRI
| .|.|   .    . ||| ||. |. |.   ..||.  || .|.   || 
vtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrs
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 305-331 8.4e-06 20.0 In-house 214-240 (319) alignment 
Range on Protein: 305-331
Range on HMM: 214-240/319.0
NAEGAIAVHCKAGLGRTGTLIACYIMK
. .| | ||| || ||||| |.  .| 
tqsgPivvhCsaGvGRtGtfivldaml
subfamily_PTPRD_pd Subfamily PTPRD 304-330 8.7e-06 19.6 In-house 211-237 (564) alignment 
Range on Protein: 304-330
Range on HMM: 211-237/564.0
ENAEGAIAVHCKAGLGRTGTLIACYIM
|. .| | ||| || ||||| |.  .|
epdagPivVhCSaGVGRTGtfividam