Gene DUSP11 in Homo sapiens

Synonym: PIR1, DUSP11

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP014_AA protein Get Run
HsapP014_AA_86-248 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 78-249 4.9e-82 268.1 In-house 1-173 (178) alignment 
Range on Protein: 78-249
Range on HMM: 1-173/178.0
IPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPET-VPYLKIFTVGHQVPDDETIFK
.|.|||.| |||....||||||||.||..||.||.. |..|.| ||..|..|.|..|||.||||.|.||||...| .. | |||....||.||..|.. |
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkk

FKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQNG
||.||. ||..|||||||||||||||.||||||||||||||||..|.|||| |...|||.|||.||..||.. 
fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
0038934 (Phosphotyrosine protein) phosphatases II 78-248 3.4e-53 175.5 In-house 2-171 (194) alignment 
Range on Protein: 78-248
Range on HMM: 2-171/194.0
IPERWKDYLPVGQRMPGtRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPE-TVPYLKIFTVGH-QVPDDETIF
.|.||..| .||.. .| |||||||||..|..| . .. .||| ||.. ....|..|||.||||.| ||| ||....  . |||......  ||..|...
lPdrwlkyervgdiitg.rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

KFKHAVNGFLkeNKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQN
.| ..|. ||  |.|......|||..||.|||.|...||| . |  ...||.||...|......|.|.|.|. 
rfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk
subfamily_RNGTT_pd Subfamily RNGTT 79-248 1.4e-42 139.6 In-house 1-169 (189) alignment 
Range on Protein: 79-248
Range on HMM: 1-169/189.0
PERWKDYLPVGQRMpGTRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPE-TVPYLKIFTVGHQV-PDDETIFK
||||..    |. .   .|..|| || |.....|| |. |.|  |.. .. ....|||.|||| |.|||. |.| .  . | |. . |... |. | . .
PerWlnCPrkgkli.aekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FKHAVNGFLKenKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQN
|.. |. | |  |  ...|||||||| ||||.||. ||...| .  ..|..||...|   . ...|...| .
fiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellr
0036282 (Phosphotyrosine protein) phosphatases II 81-247 3.7e-27 90.5 In-house 3-163 (174) alignment 
Range on Protein: 81-247
Range on HMM: 3-163/174.0
RWKDYLPVGQRMPGTRFIAFKVPLQksfekKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYkpeDLPETVPYLKIFTVGHQVPDDETIFKFKHA
.. .. |..  .  .|.||...||.      ..    ..  .... ..|.  .|...|..... |..     .. . ||.. ...|.|||......|  .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelred...lerlgiqylylpwpDhgvpdlsillefvkf

VNGFLKEnkDNDKLIGVHCTHGLNRTGYLICRYLIDVEGV-RPDDAIELFNRCR---GHCLERQNYIEDLQ
|. .|.|  |... . |||..|..|||.|.. ||. . .  ...||..|. ..|   ... ....... |.
veealse..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0041856 (Phosphotyrosine protein) phosphatases II 76-243 1.5e-24 82.0 In-house 1-160 (182) alignment 
Range on Protein: 76-243
Range on HMM: 1-160/182.0
NHIPERWKDYLPVGQR--------------MPGTRFIAFKVPLQKsfekklapeecfSPLDLFNKIREQneELGLIIDLTytQRYYKPEDLPETV-PYLK
|.  .|..|.||. .               .|.|||||...||..            .. | .. ..|.    ..|..||   ..| ||.|. ..  ||.
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgplls............tvadflrmlkel..gittivnlt..eelywpellerlgiqyly

IFTVGHQVPDDETIFKFKHAVNGflkenkdNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYI
..  .| ||| .....| ..|.        ... . |||..|..|||.|.. ||. . || ...|..|....| .. .. |..
lpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqy
0045450 (Phosphotyrosine protein) phosphatases II 81-246 1.1e-23 79.9 In-house 93-296 (307) alignment 
Range on Protein: 81-246
Range on HMM: 93-296/307.0
RWKDYLPVGQRMPGTRFIAFKVPLQKsfekklapeecfSPLDLFNKIREQNeeLGLIIDLTYTQ------------------------------------
|. ..|...    ...|||...||..            .. | .. ..||.   ..|..|| .                                     
rvpllllldgydlkrkfIatqgPlpe............tvedFwrmlweqg..vtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgy

--RYYKPED--LPETVPYLKIFTV----GHQVPDD-ETIFKFKHAVNGFLKENkDNDKLIGVHCTHGLNRTGYLICRYLIDVEG--------VRPDDAIE
  |... .|    . . ....|      .|.||.. |....| ..|. .|.|. .... . |||..|..|||..|. ||. . .        | ...|..
tvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavk

LFNRCRGHCLERQNYIEDL
|. ..|... . ..... |
llreqRpgavqnpeqyrfl
0040439 (Phosphotyrosine protein) phosphatases II 76-246 1.5e-22 75.9 In-house 11-238 (249) alignment 
Range on Protein: 76-246
Range on HMM: 11-238/249.0
NHIPERWKDYLPVGQRMP------------------------GTRFIAFKVPLQKsfekklapeecfSPLDLFNKIREQNeeLGLIIDLTYTQR------
|.   |..|.||  . ..                        ..||||.. ||..            .  | .. ..|..   . |..|| ...      
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe............tvedfwrmlwelg..itvivmLtslvelgrekc

--------------------------------------YYKPEDLPETVPYLKIFtvGHQVP-DDETIFKFKHAVNGFLKENkDNDKLIGVHCTHGLNRT
                                      |....     ..|...    |.|| . |....| .||. .|.|. .... . |||..|..||
aqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRt

GYLICRYLI-----DVEGVRPDDAIELFNRCRGHCLERQNYIEDL
|..|. ||.        || ...|..|....|... . ..... |
GtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 72-243 2.1e-21 72.0 In-house 41-266 (278) alignment 
Range on Protein: 72-243
Range on HMM: 41-266/278.0
KKGGNHIPERWKDYLPVGQRMP------------------------GTRFIAFKVPLQKsfekklapeecfSPLDLFNKIREQN----------------
..  |.   |.||.||  . .                         ...|||.. ||..            .. | .. ..|..                
llpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe............tvedFwrmvwelgvttivmLtelvelgrv

-------------------------EELGLIIDLTYTQRYYKPEDLPETVPYLKIFtvGHQVP-DDETIFKFKHAVNGFLKenkDNDKLIGVHCTHGLNR
                         ..   ...|. | ......     . ||..    |.|| . .....| .||. .|.   |... . |||..|..|
kcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgR

TGYLICRYLI-----DVEGVRPDDAIELFNRCRGHCLERQNYI
||..|. ||.     .  || ...|.. ....|..... ....
TGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy
0040438 (Phosphotyrosine protein) phosphatases II 91-244 3.7e-21 71.1 In-house 18-266 (317) alignment 
Range on Protein: 91-244
Range on HMM: 18-266/317.0
RMP----------------------------------------------------------------GTRFIAFKVPLQKsfekklapeecfSPLDLFNK
...                                                                ...|||...||..            .  | .. 
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn............tvedFwrm

IREQneELGLIIDLTYTQRY--------Y---------------KPEDLPETVPYLKIFT-------------------VGHQVP-DDETIFKFKHAVNG
. ||   ...|. || .  .        .               . |.  . . ....                       | || . .....| .||. 
vweq..gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

FLKenkDNDKLIGVHCTHGLNRTGYLICRYLI-----DVEGVRPDDAIELFNRCRGHCLERQNYIE
.|.   |... . |||..|..|||..|. ||.       .|| ...|.. ....|... .  ....
ale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr
0037934 (Phosphotyrosine protein) phosphatases II 84-246 5.7e-21 70.6 In-house 33-234 (243) alignment 
Range on Protein: 84-246
Range on HMM: 33-234/243.0
DYLPVGQRMPGTRFIAFKVPLQKSFEKklapeecfSPLDLFNKIREQneELGLIIDLTYTQ---------------------------------------
||.. .  .   |.||. .||....|          . . .. . |.    . |..|| ..                                       
dyinanliyvtprliatqgPlpetved........dlasfwrmlwel..gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtll

-RYYK-PEDLPETVPYLKIFTVGHQVPD-DETIFKFKHAVNGFLKE-----NKDNDKLIGVHCTHGLNRTGYLICRYLIDVE-GVRPDDAIELFNRCRGH
 .... ..   . . |. .   .|.|||  | . .| ..|. |..|     . |... . |||..|..|||.||. ||.    || ...|..|. ..|..
lenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg

-CLERQNYIEDL
 . . ..... |
kavqtpsqyrfl
0048076 (Phosphotyrosine protein) phosphatases II 128-247 5.7e-21 70.1 In-house 24-136 (145) alignment 
Range on Protein: 128-247
Range on HMM: 24-136/145.0
REQNEELGLIIDLTYTQRYYKpedlPETVPYLKIFTVGHQVPDD-ETIFKFKHAVNGFLKEnkdnDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAI
. ..  ......||.......    .. . || . . .|.|||. |.. .| .... .|||    .. . |||..|..|||.|.. ||.  .|| ...|.
llkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmlllgvsleeal

ELFNRCRGHCLERQNYIEDLQ
||. ..| .. ....... |.
elvrsqrpgavpnpgqlrfly
0044763 (Phosphotyrosine protein) phosphatases II 131-247 1.5e-20 69.0 In-house 46-164 (178) alignment 
Range on Protein: 131-247
Range on HMM: 46-164/178.0
NEELGLIIDLTYTQRYYKPEDLPET-----VPYLKIFTVGHQVPD-DETIFKFKHAVNGFLKenkDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDD
.. ...|..|| ..........|.      . ||.| ...| ||| .| ...| .... .|.   .... . |||..|..|.|.|.. ||. . |. ...
elgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglslee

AIELFNRCRGhCLERQNYIEDLQ
||||. ..|  . ....... |.
aielvrerRp.ivpnpgqlrqLy
0048179 (Phosphotyrosine protein) phosphatases II 129-246 1.9e-20 68.5 In-house 25-137 (144) alignment 
Range on Protein: 129-246
Range on HMM: 25-137/144.0
EQNEELGLIIDLTYTqrYYKPEDLPETVPYLKIFTVGHQVPDD-ETIFKFKHAVNGFLKenkdNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIE
 ..  ....|.|| .  |....  .| . ||.. . .|.|||. | . .| .... .|.    ... . |||..|..|||.|.. ||. ..|. ...|..
lkklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

LFNRCRGHCLERQNYIEDL
|. ..| .. . ..... |
lvrsrrpgavpnpgqlrfL
0042113 (Phosphotyrosine protein) phosphatases II 96-246 5.5e-20 67.3 In-house 53-235 (245) alignment 
Range on Protein: 96-246
Range on HMM: 53-235/245.0
RFIAFKVPLQKsfekklapeecfSPLDLFNKIREQNeeLGLIIDLTYTQR--------------------------------------------YYKPED
.|||.  ||..            .. | .. ..|..  .  |..|| .                                              ..... 
kfiatqgPlpe............tvedfwrmlwelg..ittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesr

LPETVPYLKIFtvGHQVPD-DETIFKFKHAVNGFLKEnkDNDKLIGVHCTHGLNRTGYLICRYLI-----DVEGVRPDDAIELFNRCRGHCLERQNYIED
   .. || .   .|.||| .|....| ..|. .|.|  |... . |||..|..|||..|. ||.        || ...|.. ....|... . ..... 
evihyhylpwp..dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrf

L
|
l
0049772 (Phosphotyrosine protein) phosphatases II 121-247 6e-20 67.6 In-house 163-267 (314) alignment 
Range on Protein: 121-247
Range on HMM: 163-267/314.0
LDLFNkireqneelgliidltytQRYYKPEDLPET-VPYLKIFTVGHQVPDDETIFKFKHAVNGFlkenkDNDKLIGVHCTHGLNRTG-YLICRYLIDVE
|.|..                  ...| ||..... . || | . ....|..| . .| .... .     |... . |||..| .||| .... ||.   
lellk..................eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll

GVRPDDAIELFNRCRGhCLERQNYIEDLQ
|| ...|.| . ..|  .  ....|| |.
gvsleealedvrlkRp.inpnpgfieqle
0049260 (Phosphotyrosine protein) phosphatases II 133-246 5.7e-19 63.8 In-house 31-142 (152) alignment 
Range on Protein: 133-246
Range on HMM: 31-142/152.0
ELGLIIDLTYTQRYYKPED-LPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLkeNKDNDKLIGVHCTHGLNRTGYLICRYLIDvEGVRPDDAIELFNR
|||  . ...|........  ..   || ...  | |||.. ...| . .  .|  ..|... . |||..|..||| |.. ||.   || ...|..|. .
elgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

CRGHCLERQNYIEDL
.| .  . ..... |
kRpgavpnpgqlrfl
0043147 (Phosphotyrosine protein) phosphatases II 124-246 7e-19 63.6 In-house 37-153 (172) alignment 
Range on Protein: 124-246
Range on HMM: 37-153/172.0
FNKIREQNEELglIIDLTyTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLkeNKDNDKLIGVHCTHGLNRTGYLICRYLIDvEGVRPD
.. ..|..  .  |..|| .  |...   .. . || .    | ||. | . .| . .. .|  ...... . |||..|..|||.|.. ||.  .|. ..
wrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.lglsle

DAIELFNRCRGHCLERQNYIEDL
.|..|. ..|... . ....  |
eavalvrekRpgavqnpsqyrfl
0046846 (Phosphotyrosine protein) phosphatases II 131-243 3.8e-18 61.3 In-house 45-162 (176) alignment 
Range on Protein: 131-243
Range on HMM: 45-162/176.0
NEELGLIIDLTYTQ-------RYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENkdndKLIGVHCTHGLNRTGYLICRYLIDV-EGVRP
..  .....||  .        .| ||   . . || . .. |.|||.| ....  ... .|||.    . . ||| .|..||| |.. ||.    |. .
elgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg....gpvlVHCsaGigRtgtlvaayllelekglsv

DDAIELFNRCRG-HCLERQNYI
..|..|. ..|  .... ....
eealalvreqRplgavqtpeQy
0039614 (Phosphotyrosine protein) phosphatases II 81-243 5.5e-18 60.9 In-house 61-278 (297) alignment 
Range on Protein: 81-243
Range on HMM: 61-278/297.0
RWKDYLPVGQRMP--------------------------GTRFIAFKVPLQKsfekklapeecfSPLDLFNKIREQneELGLIIDLTYTQRY------YK
| ||.||  . .                           . .|||.. ||..            .. | .. ..||      |. || .  .      | 
rykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe............tvedFwrmvweq..gvtvivmLtklvelgrkcaqyw

PEDLPetvpYLKIFTV------------------------------------GHQVP-DDETIFKFKHAVNGFLKENkDNDKLIGVHCTHGLNRTGYLIC
||.      . . |||                                     |.|| . |....| ..|. .|.|. .... . |||..|..|||..|.
peegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfia

RYLI-----DVEGVRPDDAIELFNRCRGHCLERQNYI
 ||.        || ...|.. ....|... .  ...
aylmleqlekeggvdvleavkelreqRpgavqtpsqy
PTEN_1 136-235 1.6e-17 58.9 In-house 70-173 (196) alignment 
Range on Protein: 136-235
Range on HMM: 70-173/196.0
LIIDLTY-----TQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDnDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFN
|...|.      ...|.. |   . | ||..    |..|. . .|..   .   |.....  . . |||..||.|.| ... ||.  ..  .|.|.||..
lvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvr

RCRGH
..| .
ekRpp
0048567 (Phosphotyrosine protein) phosphatases II 137-237 3.7e-16 53.8 In-house 8-122 (157) alignment 
Range on Protein: 137-237
Range on HMM: 8-122/157.0
IIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVP-----------DDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGL---NRTGYLICRYLIDVEGVRP
|.... .  ..    ||. .. ...|.. ...            .  ....| . .| |||  . ..| | |||..||    ||..||. ||| . |  |
ieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp

DDAIELFNRCRGHCL
..||...  .| ...
eeaiaplrivrpgsv
0051082 (Phosphotyrosine protein) phosphatases II 130-237 1.1e-15 53.0 In-house 30-136 (151) alignment 
Range on Protein: 130-237
Range on HMM: 30-136/151.0
QNEELGLIIDLTYTQ-RYYKPEDLPE-TVPYLKIFTVGHQVPDDETIFkfkHAVNGFLKENKDN-DKLIGVHCTHGLNRTGYLICRYLIDvEGVRPDDAI
... .  |..|. .. |.| || |||  . .| |  .....|. ...|   .||. ||..  |. .. . |||..|..||| |.. ||.  .|| ...|.
kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsf...davleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleeal

ELFNRCRGHCL
| . ..|... 
eeyrlkrpgvv
DSPc Dual specificity phosphatase, catalytic domain 166-247 1.7e-15 52.1 Pfam-A 49-128 (133) alignment 
Range on Protein: 166-247
Range on HMM: 49-128/133.0
HqvPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQ
    ... | |.  ..  |... ... | . |||..|..|...||..||.. .... ..|.|.... |..  .. ...  | 
d..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
DSPc Dual specificity phosphatase, catalytic domain 166-247 1.7e-15 52.1 In-house 49-128 (133) alignment 
Range on Protein: 166-247
Range on HMM: 49-128/133.0
HqvPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQ
    ... | |.  ..  |... ... | . |||..|..|...||..||.. .... ..|.|.... |..  .. ...  | 
d..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
0045098 (Phosphotyrosine protein) phosphatases II 81-239 4.1e-15 51.4 In-house 38-257 (278) alignment 
Range on Protein: 81-239
Range on HMM: 38-257/278.0
RWKDYLPVGQRM------------PGTRFIAFKVPLQksfekklapeecFSPLDLFNKIREQNeeLGLIIDLT---------------------------
| ||.||. . .            ....|||.  ||.                | .. ..|..     |. ||                           
RykdilpydhsrVkdYINAsyidgypkkfIatqgPlp............stvadfwrmlwelg..itvivmltelvelgrekcaqywpeggsltygdftv

------------------YTQRYYKPEDLPETVPYLKI-FTVGHQVPDDE---TIFKFKHAVNGFLK----------ENKDNDKLIGVHCTHGLNRTGYL
                  .   ...... . .| .|.. .   | ||...    ....   .. .||             |... . ||| .|..||| |
tllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl

ICRYLIDVE---GVRPDDAIELFNRCRGH-CLER
.. ||.      || ...|.. . ..|.. ... 
vaaylmlelleggvdlleavkelrsqRpglavqn
PTPc_motif_SM00404 157-247 1.6e-14 49.0 In-house 45-135 (140) alignment 
Range on Protein: 157-247
Range on HMM: 45-135/140.0
PYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQ
.  .|. . ..  . . ..|.  .|. |... ... . . |||..|..|...||. ||.. ...  ..|.|.... | .  .. |... |.
sgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLi
0046845 (Phosphotyrosine protein) phosphatases II 92-240 1.2e-12 43.3 In-house 74-260 (284) alignment 
Range on Protein: 92-240
Range on HMM: 74-260/284.0
MPGTRFIAFKVPLQKS----------------------FEKKLAPEECFSPLDlfN--------K---IREQNEELGLIIDLTYTQRYYkpedlPETVPY
.   .|||.. ||...                      .|..    . . ||.  .        .   ..|....   .. |. |   |     .. . .
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgy.....tgesrt

LKIFT----VGHQVP-DDETIFKFKHAVNGFLKEnKDNDKLIGVHCTHGLNRTGYLICRYLIDVE--------GVRPDDAIELFNRCRGHCLERQ
...|       |.|| . | ...| ..|. .|..  .... | ||| .|..|||..|. .|.           || . .|.  . ..| .. .  
vthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0047943 (Phosphotyrosine protein) phosphatases II 163-241 1.2e-12 43.3 In-house 176-259 (273) alignment 
Range on Protein: 163-241
Range on HMM: 176-259/273.0
TVGHQVP-DDETIFKFKHAVNGFLKENKDNdKLIGVHCTHGLNRTGYLICRYLI-----DVEGVRPDDAIELFNRCRGHCLERQN
   |.|| . | ...| ..|. .|.....| . . ||| .|..||| .|. .|.        || ...|. |. ..| .. .  .
wpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0050432 (Phosphotyrosine protein) phosphatases II 160-240 6.7e-12 40.8 In-house 166-285 (308) alignment 
Range on Protein: 160-240
Range on HMM: 166-285/308.0
KIFTV--------------------------------------GHQVPDD-ETIFKFKHAVNGFLkenkdNDKLIGVHCTHGLNRTGYLICRYLI-----
. |||                                       |.||.. | ...| ..|. .|     ... | ||| .|..||| .|. .|.     
gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqle

DVEGVRPDDAIELFNRCRGHCLERQ
   || . .|.  . ..| .. .  
keggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 144-240 1.1e-11 40.1 In-house 164-272 (288) alignment 
Range on Protein: 144-240
Range on HMM: 164-272/288.0
QRYYKPED-----LPETVPYLKIFTV----GHQVPD-DETIFKFKHAVNGFLKenkDNDKLIGVHCTHGLNRTGYLICRYLI-----DVEGVRPDDAIEL
.|. . ..      .... . ..| .     |.|||  | ...| ..|. .|.   .... . ||| .|..||| .|. .|.       .|| . .|.. 
vrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr

FNRCRGHCLERQ
. ..| .. .  
lreqRpgmvqtp
subfamily_VSP_pd Subfamily VSP 144-234 2.9e-11 37.7 In-house 84-171 (212) alignment 
Range on Protein: 144-234
Range on HMM: 84-171/212.0
QRYYKPEDLPETVpyLKIFTVGHQVPDDETIFKFKHAVNGFLKenKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVR-PDDAIELFNRCRG
.| | .. . . |   .| .  |.||  | ...| . |. .|.  ||..... .||  | .||| ..| .|.  | ..  ..... |   | 
eraydekyfnnrv..kriliddhnvpkleellvftkevkewle..kdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrt
0051429 (Phosphotyrosine protein) phosphatases II 128-241 6.7e-11 37.9 In-house 40-212 (272) alignment 
Range on Protein: 128-241
Range on HMM: 40-212/272.0
REQNEELGLIIDLTYTQ--RYYKPEDLPETVPYLKIFTVGHQVPDDETIF---------------------------------------------KFKHA
| ... .  |.||. .    ..| . ... . || . .... .|. . ..                                               ..|
rlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea

VNGFLKENKDnDKLIGVHCTHGLNRTGYLICRYLIDvEGVR--------------PDDAIELFNRCRGHCLERQN
.  .|..  | .. . |||..| .||| ... .|.  .||               ...|.|   ..| .  . . 
llellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
subfamily_PTEN_pd Subfamily PTEN 143-234 2.5e-10 35.6 In-house 69-157 (184) alignment 
Range on Protein: 143-234
Range on HMM: 69-157/184.0
TQRYYKPEDLPETVPYLKIFtvGHQVPDDETIFKFKHAVNGFLKENKdnDKLIGVHCTHGLNRTGYLICRYLIDVEGVR-PDDAIELFNRCRG
..|.|. ... . |. ...    |. |  | . .. . .. .|.|.|  .... |||  |  ||| ||. ||.    .. ...|.|||.. | 
serkydskkfdgrvavypfd..Dhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
0036941 (Phosphotyrosine protein) phosphatases II 164-238 3.4e-10 35.2 In-house 179-261 (297) alignment 
Range on Protein: 164-238
Range on HMM: 179-261/297.0
VGHQVPD-DETIFKFKHAVNGFLKENKDNdKLIGVHCTHGLNRTGYLICRYLI--------DVEGVRPDDAIELFNRCRGHCLE
  | ||.  .....| ..|. .||.  .. . . ||| .|..|.| .|. .|.          .|| . .|.  . ..| .. .
pdhgvpespaslldfielvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
subfamily_PTPDC1_pd Subfamily PTPDC1 193-247 1.6e-08 29.2 In-house 115-169 (182) alignment 
Range on Protein: 193-247
Range on HMM: 115-169/182.0
KLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQ
. ..|||  || ||| ||. ||. .. . ...||.|    | .... .. .| ..
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvk
PTPc_DSPc_SM00012 166-216 3.9e-08 28.8 In-house 13-63 (105) alignment 
Range on Protein: 166-216
Range on HMM: 13-63/105.0
HQVPD-DETIFKFKHAVNGFLKENKDnDKLIGVHCTHGLNRTGYLICRYLID
|.||.  . |... .||. . .....  | . ||| .| .|||.... ... 
hgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldill
subfamily_PTPMT1_pd Subfamily PTPMT1 155-246 1e-07 26.5 In-house 73-161 (171) alignment 
Range on Protein: 155-246
Range on HMM: 73-161/171.0
TVPYLKIFTVGHQ-VPDDETIFKfkhAVNgFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDL
 | .|.. || .   || |...|   .|. |... ... | . |||  |  |.. |.  ||.  | . |..|..  ...| . . ...  . |
gveqlqlatvDfteapdleklek...gve.fiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkal
subfamily_DSP23_pd Subfamily DSP23 154-238 2.5e-07 25.5 In-house 50-130 (148) alignment 
Range on Protein: 154-238
Range on HMM: 50-130/148.0
ETVPYLKIFTVGHQVPDDETIFKFKHAVNgflkENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLE
 .. . ..    .. |  | . .| . |.    | ..... ..|||  |  ||| ..  ||.  ...   .||    | |   .|
pnltlvrlriddyhppaleqvvefvrvve....eaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsve
subfamily_CDC14_pd Subfamily CDC14 96-247 2.6e-07 24.8 In-house 179-320 (328) alignment 
Range on Protein: 96-247
Range on HMM: 179-320/328.0
RFIAFKVPLQKSFEKKLApeECFSPLDLFNKIREQNeeLGLIIDLTyTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFlkenkdnDKLI
.|.|.  | .|| ...    .. .|  |..  |..|  .  .. |   . | . .   . . .  .| .   .|.|. . || ....         .  |
kflalagPhnkskledgy..plhaPeklleyfrknn..vttvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGai

GVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGH-CL-ERQNYIEDLQ
 |||  || ||| ||  ||.   ..   .||  .  ||    .  .|...|. |
avhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekq
subfamily_DSP12_pd Subfamily DSP12 170-247 5.5e-07 24.1 In-house 60-137 (155) alignment 
Range on Protein: 170-247
Range on HMM: 60-137/155.0
DDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQ
..| |...   .. |..|  .... . |||. |. |   ..  ||.  |..  ..|..| .. . .    ....| |.
peediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLk
subfamily_PRL_pd Subfamily PRL 168-239 1e-06 22.9 In-house 68-136 (151) alignment 
Range on Protein: 168-239
Range on HMM: 68-136/151.0
VPDDETIFKFKHAVNGFLKENkdNDKLIGVHCTHGLNRTGYLICRYLIDvEGVRPDDAIELFNRCRGHCLER
|| .| . .. . ..   ||.  ... ..|||  || |.  |..  ||. .|....||.|.  . |  ....
vPpeevveeWlellkekfkee..pkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgains
subfamily_DSP19_pd Subfamily DSP19 170-246 3.4e-06 21.5 In-house 67-143 (152) alignment 
Range on Protein: 170-246
Range on HMM: 67-143/152.0
DDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDL
..... .. ... .|..| ...|  . |||  |  |.  ..  ||.  | ..  .|.||    |      . .|. |
petdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqL