Gene DUSP12 in Homo sapiens

Synonym: DUSP1, YVH1, DUSP12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP015_AA protein Get Run
HsapP015_AA_24-173 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 27-181 4.8e-58 189.9 In-house 2-155 (155) alignment 
Range on Protein: 27-181
Range on HMM: 2-155/155.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEE-PSFKAGPGVEDlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
. ...||||.||..||.|...|.|..||.||.|..|| |..|. .|  .  ..|...||.||.|.|||||..|.|| .|..|..||||||.|||||||.|
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvs..tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvti

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIYKQ
..|.|||...|..|||.....  |||...|||| .||||...||..||||.  ||.
viAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayke
subfamily_DSP19_pd Subfamily DSP19 26-167 1.6e-33 110.2 In-house 11-148 (152) alignment 
Range on Protein: 26-167
Range on HMM: 11-148/152.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAgpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. ||.| ||.|   ..|. . |.| .|| .| |  . | . .    .|.  | .. ||.|||||||.|.... || .|| .  ||||||.||||||...
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfp....kdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. |.|||. .| .|.|.|...  .| .| ||||  ||| |.|
viaylmkkeelsleealelvrearpcikPneGFikqLkeyea
0044763 (Phosphotyrosine protein) phosphatases II 25-169 7.4e-32 105.8 In-house 21-170 (178) alignment 
Range on Protein: 25-169
Range on HMM: 21-170/178.0
GQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAG-----PGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQAR-AEGRAVLVHCHAG
  . |. |||| |.. ... .. |.| |||..... .| . .. .     |  ...  |..|  | ...|||.|....|.|| .|.  .|..|||||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVAIITAFLMKTDQLPFEKAYEKLQILKPeAKMNEGFEWQLKLYQAMG
|.|| ... |.|||. .|..|.|.| ..  .| .  |.|.  ||.... . 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
PTPc_motif_SM00404 27-167 6.7e-30 98.8 In-house 2-139 (140) alignment 
Range on Protein: 27-167
Range on HMM: 2-139/140.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. .. |.||.|.. .  .|. | . |||.|. | .| .  |. .|..   .| .|  |. ...|. .||....|| .|...|..||||| ||||||...|
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfq...ilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
.|.||...||  ..||| ..  .|  . |..|  ||  |. 
iaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048076 (Phosphotyrosine protein) phosphatases II 27-167 7.1e-30 99.0 In-house 4-140 (145) alignment 
Range on Protein: 27-167
Range on HMM: 4-140/145.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKagpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. |. ||||.|.  .. . ..|.. |||.||.. ||.. ..     .... |..|  | .. |||..|.....|| .|..||. |||||.|||.|. ...
pseilpglylgslptaldlellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
 |.||.. ....|.|.|...   | | .|.|.  .|.... 
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 27-166 4.6e-29 96.4 In-house 4-141 (144) alignment 
Range on Protein: 27-166
Range on HMM: 4-141/144.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEepSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. |. ||||.|.  .. . ..|.. |||.|... .|    .. ...| .  |..|  | .  |||..|.....|| .|..||. |||||.|||.|. ...
pseilpglylgslptaldlellkklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
.|.|||. .|..|.|.. ..   | | .|.|. ..|..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_DSP14_pd Subfamily DSP14 25-167 5.1e-29 95.2 In-house 5-142 (157) alignment 
Range on Protein: 25-167
Range on HMM: 5-142/157.0
GQMLEVQPGLYFGgAAAVAEPDHLREAGITAVLTVDSEEPSfKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVA
 .. ...| |. . ..|. ... |....||... |  | |. .  ...|   |. ||. |.||..| .|.|. .. | .....| ..|||| |||||| .
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdie...rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAs

IITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. .|.|||. .|  ..||. ..  .|  . | ||  ||  |  
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
subfamily_DSP15_pd Subfamily DSP15 27-168 5.8e-29 95.1 In-house 2-138 (151) alignment 
Range on Protein: 27-168
Range on HMM: 2-138/151.0
MLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSeepsfKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
. .| |||| |.     . . |.|  || .|.|        | . ..|.  ....| | |...| .... .| || ..| .. .||||| ||||||| ..
iskvlpglylgnfrdskdeelLkeknithilsvhd.....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlv

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
.|.||   .| ...| | ..  .  |. | ||. ||| |. .
vaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
DSPc Dual specificity phosphatase, catalytic domain 34-166 1.6e-27 90.9 Pfam-A 1-131 (133) alignment 
Range on Protein: 34-166
Range on HMM: 1-131/133.0
LYFGGAAAVAePDHLREAGITAVLTVDSEEPSFkAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
||.|.. .   .. | . |||.|. | .| |        ..  .| .|  |. ||.. ..|...|.|| .|...|. ||||| ||.||| ..|.|.||||
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

DQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
..|. ..||| ..  ..    |.||  ||  |.
knlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 34-166 1.6e-27 90.9 In-house 1-131 (133) alignment 
Range on Protein: 34-166
Range on HMM: 1-131/133.0
LYFGGAAAVAePDHLREAGITAVLTVDSEEPSFkAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
||.|.. .   .. | . |||.|. | .| |        ..  .| .|  |. ||.. ..|...|.|| .|...|. ||||| ||.||| ..|.|.||||
lylgskstas.lalleklgitlvinvtkevpnn.naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

DQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
..|. ..||| ..  ..    |.||  ||  |.
knlslneAyefvkerrskispnagflrqLleye
subfamily_DSP6_pd Subfamily DSP6 26-166 1.6e-26 86.7 In-house 13-151 (158) alignment 
Range on Protein: 26-166
Range on HMM: 13-151/158.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
  .|. | ||.| | . .. . |.. .|  || | |. |.. .    ..|  | .|. |. ...| ...   ..|| .|| .  .|||||.||.||||..
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfee..sgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
. |.|||. .| ...||. ..  |..   |  |  ||. ..
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfe
subfamily_DSP10_pd Subfamily DSP10 26-165 6.3e-25 81.9 In-house 13-149 (159) alignment 
Range on Protein: 26-165
Range on HMM: 13-149/159.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. .| | |..| .   |. | |.. .||||| | .. | . ..   |.|    .|. |. . .|  . .  ..|| .|| .|. |||||.||.|||...
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee...ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
. |.|||  .| ...||.  .  .|    | .|  ||. .
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlef
subfamily_DSP1_pd Subfamily DSP1 29-167 3.2e-24 79.9 In-house 20-154 (163) alignment 
Range on Protein: 29-167
Range on HMM: 20-154/163.0
EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGpgvedLWR-LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIIT
.... ||.|..   .. . |.. ||||.| | .| . .        |..   ..  |.|. |. ..... . || ......  ||.||.||.||| ... 
kildfLylGsetvasnleiLkslgitailnvskeldnvfed.....lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
|.||||... .|.|..  .  ..  . | ||  ||. |. 
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
0045098 (Phosphotyrosine protein) phosphatases II 25-169 1.4e-23 79.1 In-house 20-271 (278) alignment 
Range on Protein: 25-169
Range on HMM: 20-271/278.0
GQMLEVQPGLYFGGAA-----------------------------------------AVAEPDHLREAGITAVLTVDSEE--------------------
|.. |. |.|| |...                                         . .  . |.| |||..... ...                    
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

----------------------------PSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA--------------EGRAVLVHCHAGVSR
                            ..     ||. |. |..|  . |....|....... || .|..              .|  |||||.|||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SVAIITAFLMKTD---QLPFEKAYEKLQILKPE-AKMNEGFEWQLKLYQAMG
. ... |.||..    .. ...|...|.  .|  | .|... ..|  .... 
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0049772 (Phosphotyrosine protein) phosphatases II 77-168 1.5e-23 79.4 In-house 183-272 (314) alignment 
Range on Protein: 77-168
Range on HMM: 183-272/314.0
RLFVPALDkPETDLLSHLDRCVAFIGQArAEGRAVLVHCHAGVSRSV-AIITAFLMKTDQLPFEKAYEKLQILKPeAKMNEGFEWQLKLYQAM
 | .|  | ....||...|....|| .|  .|..|||||.||..|.  ....|.|||  ....|.|.| ..   | ...|.||  ||..|. .
ylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
0041856 (Phosphotyrosine protein) phosphatases II 28-173 3.2e-23 77.7 In-house 20-176 (182) alignment 
Range on Protein: 28-173
Range on HMM: 20-176/182.0
LEVQPGLYFGGAAA--------------VAEPDHLREAGITAVLTVDsEEPSFKAGPGVEDLWRLFVPALDKPETDllshLDRCVAFIGQARAEGRAVLV
 .. ..|| |.  |               .  . |.| |||.....  ||. .      . .  |..|  | . .|    || ...|| ....||..|||
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlV

HCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKP--EAKMNEGFEWQLKLYQAMGYEVD
||.|||.|. ... |.|||. ....|.|.. ..  .|     .| .|  ||.|.. . . ..
HCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0043147 (Phosphotyrosine protein) phosphatases II 19-167 4e-23 77.4 In-house 11-158 (172) alignment 
Range on Protein: 19-167
Range on HMM: 11-158/172.0
SRVSCAGQMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDsEEPSFKAGPGVEDLWRLFVPALDKPETdLLSHLDRCVAFIGQ--ARAEGRAVLVHCH
| ...   . .. .... ..       . |.| |||.....  |.   . .   ...  |..|  | . . ||..|.... || .  |. .| .|||||.
syldlyyipdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCs

AGVSRSVAIITAFLMKtDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
|||.|..... |.||.  .|..|.|.. ..  .| |  |... ..|. .. 
aGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek
PTEN_1 25-168 4.6e-23 77.0 In-house 42-190 (196) alignment 
Range on Protein: 25-168
Range on HMM: 42-190/196.0
GqmlEVQPGLYFGGAAAV-AEPDHLREAGITAVLTVDSEEPS--FKAGPGVEDLWRLF---VPALDKPETDLLSHLDRCVAFIGQARA--EGRAVLVHCH
    |. .||| | .  | |  |.| | |||.|.....||.   .   .  .   ..    .|  | .  .| ...| |. || ....  .|..|||||.
q...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCk

AGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
||..||. .. |.||.. .| ...| | ...  | .  | ..  .|. |.|.
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
0046846 (Phosphotyrosine protein) phosphatases II 27-167 5.9e-23 77.0 In-house 12-170 (176) alignment 
Range on Protein: 27-167
Range on HMM: 12-170/176.0
MLEVQPGLYFGGAA----------AVAEPDHLREAGITAVLTVDSEEPS-------FKAGPGVEDLWRLFVPALDKPETDLlSHLDRCVAFIGQARAEGR
. .. ..|..|..             .  ..|.|.|||||... .|          .      ...  |..|  |    || ..|.....|| .|. ||.
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

AVLVHCHAGVSRSVAIITAFLMKT-DQLPFEKAYEKLQILKP-EAKMNEGFEWQLKLYQA
 |||||.||..|. ... |.|...  .|. |.|.....  .|  |  .... ..|. .  
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Slingshot_pd Subfamily Slingshot 31-168 1.5e-22 73.7 In-house 23-156 (169) alignment 
Range on Protein: 31-168
Range on HMM: 23-156/169.0
QPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAgpgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFL
   .|.|     .. ..|.| |.. .| |  |  .| .    |..  | .   |..|||||.. ..   || .|...|  |||||  ||||| ... |. 
fdhvylGsewnasnleelkengveyilnvtkeidnffp....ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
||. .| .|.|.| ..  .  .| |.||  ||. |. .
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
subfamily_DSP8_pd Subfamily DSP8 26-165 5.7e-22 72.0 In-house 14-150 (159) alignment 
Range on Protein: 26-165
Range on HMM: 14-150/159.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAI
.. .. . ||.|    | . . |.. ||. || .. . |. .  . ..    | ||  || . .||  .|. | || .|..|   ||||..|| ||| ..
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk...flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatv

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
. |..||| .. ...||. ..  .|  . |  |. ||  |
aiayimktlemsldeayrfvkekrptispnlnflgqLley
subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-167 6.2e-22 71.9 In-house 122-256 (263) alignment 
Range on Protein: 29-167
Range on HMM: 122-256/263.0
EVQPGLYFGGAAAVAEPDHLREAGITAV-LTVDSEEPSFkagPgveDLWRLFV--PALDKPETDLLSHLDRCVAFIGQARAEGrAVLVHCHAGVSRSVAI
|. ..|..||  .  .   |.. |.| . |.|   || |   |   .|.. ..   . | .| |.  |...  ||| . | .|  ||||| |||||| ..
eiidklflGgldsannksilkdlgvthillavadfePlf...P...klfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstl

ITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
. ..||| ..| |..|..  .  .|. . | ||  ||| |..
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0049260 (Phosphotyrosine protein) phosphatases II 28-165 9.3e-21 69.5 In-house 9-145 (152) alignment 
Range on Protein: 28-165
Range on HMM: 9-145/152.0
LEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPG--VedlWRLFVPALDKPETDLLSHLDRCVAFIGQ-ARAEGRAVLVHCHAGVSRSVA
 |. .... |.  .    . |.| |||..... ....  | .          |..|  | .  ||  .|. .. || . |. .|  |||||.|||.|. .
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

IITAFLMKtDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
.. |.||.  ....|.|.. ..  .| |  |.|. ..|. .
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyef
subfamily_STYX_pd Subfamily STYX 25-168 3.5e-20 65.7 In-house 10-156 (166) alignment 
Range on Protein: 25-168
Range on HMM: 10-156/166.0
GQMLEVQPGLYFGGAAA--VAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFV-PALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSR
 .| |. |||..|  .|   .  ..|.. ||| .. .  .  .    |  .| .| .|    |..  ... .| .  .|| ..  .|  ||||  ||.||
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisr

SVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
| |.. |..|.|  | . .|.  .|  .   ..||||  ||| |.|.
saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
subfamily_DSP3_pd Subfamily DSP3 26-166 1.5e-19 64.2 In-house 10-154 (162) alignment 
Range on Protein: 26-166
Range on HMM: 10-154/162.0
QMLEVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEepSF---KAGPGVE---DLWRLFVPALDKPETDLLSHLDRCVAFIGQARAE-GRAVLVHCHAG
.. || |.|| |..|.  . ..|...||| ||       .|   ..|.      ..  | ... |.||.||  . .. ..|| .| ..    |||||..|
evdevypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvG

VSRSVAIITAFLMKTDQLPFEKAYEKLQIlKPEAKMNEGFEWQLKLYQ
|||| ... |.|| . ..   .| .. .  | |   ||||  ||. ..
vsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeld
subfamily_STYXL1_pd Subfamily STYXL1 29-166 1.5e-19 63.7 In-house 13-150 (157) alignment 
Range on Protein: 29-166
Range on HMM: 13-150/157.0
EVQPG-LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFK-AGPGVedLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAII
|| || || |      .|   ..  . |.. | ..   .  . ..|     | ..  |..|.|||..|.. | ||.. . ||..|||  . |.|||.|.|
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadv..akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

TAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
 |.||   .. ..|||..|.  |.  | | .|  ||. ..
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWe
0037934 (Phosphotyrosine protein) phosphatases II 27-166 1.9e-19 65.6 In-house 39-238 (243) alignment 
Range on Protein: 27-166
Range on HMM: 39-238/243.0
MLEVQPGLYFGGA--------AAVAEPDHLREAGITAVLTVDSEE------------------------------------------PS-FKAGPGVEDL
. .| |.|. ...        .. .  . | | |||..... ...                                          ..  .    |  .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

WRLFVPALDKPE--TDLLSHLDRCVAFIGQ-----ARAEGRAVLVHCHAGVSRSVAIITAFLMKTD-QLPFEKAYEKLQILKPE-AKMNEGFEWQLKLYQ
..| .|  . |.  .|||..|| . .|| .     |. .|. |||||.|||.|. ..|.|.||..  ....|.|...|.  .|  |  .... ..|  . 
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 18-165 3.2e-19 64.8 In-house 42-238 (245) alignment 
Range on Protein: 18-165
Range on HMM: 42-238/245.0
ASRVscagQMLEVQPGLYFGGAAAVAEPD----HLREAGITAVLTVDSEEPSF------------------------------------------KAGPG
|| |     . .. |... ... .   ..     |.| |||..... .||.                                            . .. 
asyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddes

VEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA--EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKL
 |..  ...|  | ...|||..|.... |. .|.|  ..  |||||.|||.|. ..|.|.||     |.  ...|.|...|.  .| | .....  .|  
revihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye

Y
.
a
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 30-164 3e-18 59.8 In-house 10-142 (148) alignment 
Range on Protein: 30-164
Range on HMM: 10-142/148.0
VQPG-LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEdlwRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITA
.... |. |     |. . |.. |.|.. .   | .   .  |.|    | |.  |||. || .  .  .||. .|..||| ||||.. ||||| |.  .
ikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgie...YlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

FLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKL
.|.....   ..|..  .  ..  . | ||  ||  
wlidfkrvslkealalvkskrryvdpnlgfLkqLae
0051429 (Phosphotyrosine protein) phosphatases II 28-174 5.3e-18 61.1 In-house 17-229 (272) alignment 
Range on Protein: 28-174
Range on HMM: 17-229/272.0
LEVQPGLYFGGAA----AVAEPDHLREAGITAVLTVDSEE--PSFKAGPGVEDLWRLFVPALDKPETDLLSHL---------------------------
 .| ||... ...     .|. ..|.| ||...... |||  ...|  .  ... .|..| ||  ... | .                            
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------DRCVAFIGQARAeGRAVLVHCHAGVSRSVAIITAFLMKtDQLP--------------FEKAYEKLQILKPEAKMNEGFE
                     . ..... . .. |..|||||.||..|.  .. ..|.   ...               |.|.|.|.   | |  .|.. 
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

WQLKLYQAMGYEVDT
..|  . .  ..  .
lflyeallellrsll
0040439 (Phosphotyrosine protein) phosphatases II 47-167 1.3e-17 59.7 In-house 73-243 (249) alignment 
Range on Protein: 47-167
Range on HMM: 73-243/249.0
HLREAGITAVLTVDSEEPSFKAG---------------------------------------PGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARA-
 |.| |||..... |...  . .                                          |..  | .. .| |.... .... ...|| ..|  
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
     .|  |||||.|||.|. ..|.|.||     |. ....| |...|.  .| | .|...  .|  . .
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0036282 (Phosphotyrosine protein) phosphatases II 29-165 1.7e-17 59.1 In-house 14-165 (174) alignment 
Range on Protein: 29-165
Range on HMM: 14-165/174.0
EVQPGLYFGGAAAVaEPDHLREAGITAVLTVDSEEPS-----------FKAGPGVEDLWRLFVPALDKPETDLLShLDRCVAFIGQARAE--GRAVLVHC
.. |.|. |.. .    . |.| |||.|... .|..            ..  .  ...  |..|  |  . ||   |...| |. .|..|  |. |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

HAGVSRSVAIITAFLMKTDQL-PFEKAYEKLQILK---PEAKMNEGFEWQLKLY
.|||.|. ... |.||.. .| ....|.. .. |.   | .  ....  .|  .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0051082 (Phosphotyrosine protein) phosphatases II 29-160 2.8e-17 58.2 In-house 10-144 (151) alignment 
Range on Protein: 29-160
Range on HMM: 10-144/151.0
EVQPGLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVED--LWRLFVPALDKPETDLLSHLDRCVAFIGQARAE-GRAVLVHCHAGVSRSVAI
 | .||| .|.   .  . |.| ||...... |||.  .    ...  .  | .| || |...|  ..| ...|. ....  .  |||||.||..|. ..
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

ITAFLMKtDQLPFEKAYEKLQILKP-EAKMNEGFEW
. ..||.  ....|.|.| ...  |     |..|  
valylml.lgvsleealeeyrlkrpgvvqpnqqflf
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 34-142 7.6e-16 51.5 In-house 6-114 (145) alignment 
Range on Protein: 34-142
Range on HMM: 6-114/145.0
LYFGGAAAVAEPDHLREAGITAVLTVDSEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKT
|| | |    .   |.| ||. .. . . .         |..  |.. | |    ||  |.|    || . . ||  |.||| |||||||..  ||||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

DQLPFEKAY
 .. . .| 
cnmtlseaa
subfamily_MKPLT_pd Subfamily MKPLT 33-168 8.7e-16 51.9 In-house 28-159 (164) alignment 
Range on Protein: 33-168
Range on HMM: 28-159/164.0
GLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSfkAGPgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMK
 || | |  . .  .|..  || .. |  |. .  | |  . .  | |   |.... | |.|.|   |. .|   |  |||||  |.||| ..  |||.|
tlylGnakhatnekvlkdlkithivnvsqekkd..afp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

TDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
  .  ...||| |.  .  .. | ||  ||  .. .
skgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 33-168 8.7e-16 51.9 In-house 28-159 (164) alignment 
Range on Protein: 33-168
Range on HMM: 28-159/164.0
GLYFGGAAAVAEPDHLREAGITAVLTVDSEEPSfkAGPgvEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMK
 || | |  . .  .|..  || .. |  |. .  | |  . .  | |   |.... | |.|.|   |. .|   |  |||||  |.||| ..  |||.|
tlylGnakhatnekvlkdlkithivnvsqekkd..afp..ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

TDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
  .  ...||| |.  .  .. | ||  ||  .. .
skgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 81-166 9e-16 51.6 In-house 62-149 (154) alignment 
Range on Protein: 81-166
Range on HMM: 62-149/154.0
PALDKPETDLLSHLDRCVAFIGQAR--AEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
   |... |.. .||..  || .|    |   ||||...||||| |.. ..||.  .... .|.| |.  ..  | |.||  ||. ..
elfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleife
0045450 (Phosphotyrosine protein) phosphatases II 49-165 1.2e-15 53.5 In-house 128-299 (307) alignment 
Range on Protein: 49-165
Range on HMM: 128-299/307.0
REAGITAVLTVDSEEPS-----------------------------FkagpgVEDLWRLFVPALDK-----------------PETDLLSHLDRCVAFIG
.| |.|..... ....                                     ...... ..  |.                 |.... .... ...|| 
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

QARA------EGRAVLVHCHAGVSRSVAIITAFLMKTDQ--------LPFEKAYEKLQILKPEAKMNEGFEWQLKLY
..|.      .|  |||||.|||.|. ..|.|.||..          .....|...|.  .| |  |...  .|  .
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 78-167 1.7e-15 52.7 In-house 189-286 (297) alignment 
Range on Protein: 78-167
Range on HMM: 189-286/297.0
LFVPALDKPETDLLSHLDRCVAFIGQARA---EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQA
....  |    ..|..|.. . .. .|.|   .|. |||||.|||.|. ..|.|.||     |. .. ...|...|.  .| | ..... ..|  . .
qytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0040438 (Phosphotyrosine protein) phosphatases II 73-168 2e-14 49.1 In-house 154-274 (317) alignment 
Range on Protein: 73-168
Range on HMM: 154-274/317.0
EDLWRLFVPALDK----------------PETDLLSHLDRCVAFIGQARAE----GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQI
..   . ..  |.                |. .. ...| ...|. ..|.     |  |||||.|||.|. ..|.|.||     |. .. .|.|...|. 
agitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelre

LKPEAKMNEGFEWQLKLYQAM
 .| |  ....  .|  . ..
qRpgavqtpeqyrflydalle
subfamily_PTPMT1_pd Subfamily PTPMT1 78-166 2.7e-14 48.0 In-house 77-165 (171) alignment 
Range on Protein: 78-166
Range on HMM: 77-165/171.0
LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
| ..  |  |.  | .| . | || . . .|. | |||.|| .|| ......|||...|  |.| . |.  ..  ....    .|. |.
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye
0038934 (Phosphotyrosine protein) phosphatases II 88-165 8.7e-14 47.1 In-house 96-172 (194) alignment 
Range on Protein: 88-165
Range on HMM: 96-172/194.0
TDLLSHLDRCVAFIGqARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
...| .  . | ..  .. .| .|.|||.||..|.  .. |.|... ... |.|.. ... .| | .| ..  .|  .
leillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
0036941 (Phosphotyrosine protein) phosphatases II 84-168 4.9e-13 44.5 In-house 177-275 (297) alignment 
Range on Protein: 84-168
Range on HMM: 177-275/297.0
DKPETDLLSHLDRCVAFIGQARA------EGRAVLVHCHAGVSRSVAIITAFLM--------KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAM
. |. .. .. . ...|| ..|       .|  |||||.|||.|| ..|.|.||        |. .... .|. ||   .| |  ....  .|  . ..
gwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 75-165 1.5e-12 43.1 In-house 178-272 (278) alignment 
Range on Protein: 75-165
Range on HMM: 178-272/278.0
LWRLFVPALDKPEtDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLY
.. | .|  . || .| ..|| . |.. . . .. .|||||.|||.|. ..|...|.     |.  ...|.|...|.  .| | ... . ..|  .
yhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_MSG5_pd Subfamily MSG5 91-166 3.5e-12 39.7 In-house 82-157 (165) alignment 
Range on Protein: 91-166
Range on HMM: 82-157/165.0
LSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
   | |    |  |..... .||||  |.||| ..| |..||  .| ...||.||.    . . . |. .||  ..
vkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
0047943 (Phosphotyrosine protein) phosphatases II 89-159 1.2e-09 33.5 In-house 180-261 (273) alignment 
Range on Protein: 89-159
Range on HMM: 180-261/273.0
DLLSHLDRCVAFIGQARA------EGRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEAKMNEGFE
.  ..|. .. || ..|       ..  |.|||.|||.|. ..|...|.     |. .. ...|. .|.  .| . ... . 
gvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy
0050432 (Phosphotyrosine protein) phosphatases II 86-167 3.9e-09 31.7 In-house 208-294 (308) alignment 
Range on Protein: 86-167
Range on HMM: 208-294/308.0
PETDLLSHLDRCVAFIGQARAE--GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEakMNEGFEWQLKLYQA
|. .  .... ...|. ..|    |  ..|||.|||.|. ..|.. |.     |.  . ...|. ||   .|   | ...|  | ||.|
pdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg..mvqtpeqylflyra
0051299 (Phosphotyrosine protein) phosphatases II 85-152 6.8e-09 31.1 In-house 192-268 (288) alignment 
Range on Protein: 85-152
Range on HMM: 192-268/288.0
KPETDLLSHLDRCVAFIGQARAE----GRAVLVHCHAGVSRSVAIITAFLM-----KTDQLPFEKAYEKLQILKPEA
 |. .  .... ...|. ..|      |  |.|||.|||.|. ..|...|.     |.  . ...|...|   .| .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm
0046845 (Phosphotyrosine protein) phosphatases II 89-151 1.7e-07 26.4 In-house 179-255 (284) alignment 
Range on Protein: 89-151
Range on HMM: 179-255/284.0
DLLSHLDRCVAFIGQAR------AEGRAVLVHCHAGVSRSVAIITAFLMKTD--------QLPFEKAYEKLQILKPE
.  ....  ..|. ..|        |  ..|||.|||.|. ..|.. |...          .....|. .|   .| 
gvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0048567 (Phosphotyrosine protein) phosphatases II 100-166 2.9e-07 25.0 In-house 66-135 (157) alignment 
Range on Protein: 100-166
Range on HMM: 66-135/157.0
FIGQARAEGRAVLVHCHAGV---SRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQ
|... . .|.|. |||.||    .|.. .| ..|..  ... |.|.. |.|  |  ..     . | ||.
flkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
subfamily_DSP23_pd Subfamily DSP23 47-151 3.2e-07 25.1 In-house 26-127 (148) alignment 
Range on Protein: 47-151
Range on HMM: 26-127/148.0
HLREAGITAVLTVDS-EEPSFKAGPGVEdLWRLFVPALDKPETDllsHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKL
.| . |.  ....    .|  .| |..  | || ..    |  .    ... |  . .| . . || |||  |  |. .... .|.|  .|   .|  ..
ylldlgvrylvslteegrphveatpnlt.lvrlriddyhppale...qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

QILKPE
. |.| 
rrlrpg
subfamily_Laforin_pd Subfamily Laforin 78-136 6.9e-07 22.3 In-house 80-138 (183) alignment 
Range on Protein: 78-136
Range on HMM: 80-138/183.0
LFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHCHAGVSRSVAIITAFLMKTDQL
...|  |      .  | ..| ..     .|  | ||| ||| || ||.  ||.   . 
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgw
PTPc_DSPc_SM00012 82-137 7.2e-07 24.7 In-house 12-68 (105) alignment 
Range on Protein: 82-137
Range on HMM: 12-68/105.0
ALDKPE--TDLLSHLDRCVAFIGQARAeGRAVLVHCHAGVSRSVAIITAFLMKTDQLP
   .||  ...|..|. .  .  ..   .  |.|||.|||.|.  .... ..  .   
dhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_PTPDC1_pd Subfamily PTPDC1 98-151 8.6e-07 23.6 In-house 105-157 (182) alignment 
Range on Protein: 98-151
Range on HMM: 105-157/182.0
VAFIGQARAEGrAVLVHCHAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPE
|  . .|  || .| ||||||  |   .|...|. ...|  ||| ....  .|.
vkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk