Gene DUSP14 in Homo sapiens

Synonym: MKP-L, MKP6, DUSP14

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP016_AA protein Get Run
HsapP016_AA_24-169 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 23-177 7.9e-72 234.3 In-house 3-156 (157) alignment 
Range on Protein: 23-177
Range on HMM: 3-156/157.0
DIGGIAQITSSLFLGrGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLC
.. ...|||.||||. |..|....||....||.|.|.|.|.|| .....|.||||..|.|.| .  .||.|||||..|..|.|.|||||.|||||||.||
elaalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTP
.|||||.....| |||..||..||.||||||||.||||||..|.|||.||||..|
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp
subfamily_DSP1_pd Subfamily DSP1 27-166 1.5e-45 149.2 In-house 18-157 (163) alignment 
Range on Protein: 27-166
Range on HMM: 18-157/163.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYL
. .|.  |.||  .||||...|.. ||| |.|.. |..|.    ||| |..| | |.| | |.|..| . |..| .|.|  |.||.||.|||.|||.|||
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|| ..| | ||...|| ||..|.||.|| .||..||..| 
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 13-170 2e-44 146.7 In-house 9-175 (178) alignment 
Range on Protein: 13-170
Range on HMM: 9-175/178.0
LMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQ---------FEYVKVPLADMPHAPIGLYFDTVADKIHSVS-R
|. ....  .|  .. .|.  |.||    |... ||.. |||.||| | |.... ..          ..|...|. |..  ..  .|. . . |...  .
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPvIRPNVGFWRQLIDYERQLFGKST
|.|..|||| |||.||.||..||||| ....| ||...|..||| | || |..|||...|..|...|.
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_DSP10_pd Subfamily DSP10 27-166 8.4e-41 133.5 In-house 14-154 (159) alignment 
Range on Protein: 27-166
Range on HMM: 14-154/159.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWP-QFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
..|. . |||| .  |.. ..|.  .||...| | ..||.    ...| ..|. |  .  .  ||.   . |. . .|    |||| ||.|||||. |||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|||  |. | .||..|| .||.| ||..|  ||...|..| 
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP19_pd Subfamily DSP19 26-165 8.8e-41 133.8 In-house 11-150 (152) alignment 
Range on Protein: 26-165
Range on HMM: 11-150/152.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
 ..... .|.||  .||.... |. ..|| |.| ....||.   .|.|..... | | . .  |.... | |... .|.|| |||| |||||||.. |||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||| ....| ||.. |.. || |.|| ||..|| .|| .|
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
PTPc_motif_SM00404 27-163 1.4e-40 133.5 In-house 2-139 (140) alignment 
Range on Protein: 27-163
Range on HMM: 2-139/140.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
. .|.  |.||  | |.|. ||.. ||| ..|.| |...  . ..|.....|| |   ...  |.| |.| |... .|.|. ||||.|||||||||.|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYER
||. ... | |||. || ||| |.||..|.||||.||.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 34-164 3.8e-37 122.1 Pfam-A 1-133 (133) alignment 
Range on Protein: 34-164
Range on HMM: 1-133/133.0
LFLGRGSVASnRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH
|.||  | ||   ||.. ||| ..|.| |.||   .. ...||...|. |.  . |  ... . . |... .|..  ||||.||.||||||.|||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
|. | |||. || ||. |.||.||.|||..|||.
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 34-164 3.8e-37 122.1 In-house 1-133 (133) alignment 
Range on Protein: 34-164
Range on HMM: 1-133/133.0
LFLGRGSVASnRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH
|.||  | ||   ||.. ||| ..|.| |.||   .. ...||...|. |.  . |  ... . . |... .|..  ||||.||.||||||.|||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
|. | |||. || ||. |.||.||.|||..|||.
nlslneAyefvkerrskispnagflrqLleyerk
0048076 (Phosphotyrosine protein) phosphatases II 27-166 5.9e-37 121.9 In-house 4-143 (145) alignment 
Range on Protein: 27-166
Range on HMM: 4-143/145.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYL
...|. .|.||   .|... ||.  |||...| | |....    ..|. .|. |..  ..  ..... . |... ...| .|||| |||.|..||..|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|. ..| | ||...|...|| . ||.|..|.|...|..|.
mlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0041856 (Phosphotyrosine protein) phosphatases II 26-172 6.6e-37 122.2 In-house 18-179 (182) alignment 
Range on Protein: 26-172
Range on HMM: 18-179/182.0
GIAQITSSLFLGRGSV--------------ASNRHLLQARGITCIVNATieiPNFNWPQF------EYVKVPLADMPHAPiglyFDTVADKIHSVSRKHG
.. .|. .|.||                  |.. ..|. .|||.|||.|   .   ||..      .|...|  |..  .    .|.. | |. | ...|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

ATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP--VIRPNVGFWRQLIDYERQLFGKSTVK
..|||| |||.|..||..||||| ..| | ||...|. |||  ||.|| .|..||. .|..|..| ..|
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
0048179 (Phosphotyrosine protein) phosphatases II 27-165 7.3e-36 118.4 In-house 4-144 (144) alignment 
Range on Protein: 27-165
Range on HMM: 4-144/144.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQF--EYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
...|...|.||   .|..  ||.. |||...| | | ..  . ..  .|...|. |..  ..  ..... . |... ...| .|||| |||.|..||..|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
|||| ....| ||...|..||| . || |..|.|..||..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_Slingshot_pd Subfamily Slingshot 26-165 1.5e-35 116.1 In-house 18-157 (169) alignment 
Range on Protein: 26-165
Range on HMM: 18-157/169.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
  ..|   ..||    ||| . |. .|.. |.| | || ||   .|||... . | ... .  |...  . |. . .|.   ||||  ||||||.  |||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
 || ... | ||...|| || ||.|| ||..||  ||  |
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_DSP6_pd Subfamily DSP6 28-165 2.2e-35 115.5 In-house 15-154 (158) alignment 
Range on Protein: 28-165
Range on HMM: 15-154/158.0
AQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNF--NWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
..|.. |.||    |||. .|.  .|  ..| | ..||.  . ....|...|. |  .. .  .|    . |    .|. . |||| ||.||| |...||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||| ... | .||..||.|.. | ||  |  ||.|.||.|
lmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0045098 (Phosphotyrosine protein) phosphatases II 26-166 7e-35 116.2 In-house 21-272 (278) alignment 
Range on Protein: 26-166
Range on HMM: 21-272/278.0
GIAQITSSLFLGRGS-----------------------------------------VASNRHLLQARGITCIVNAT------------------------
 . .|| .|.|| ..                                         ||.. ..|.  |||.||..|                        
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSR--------------KHGATLVHCAAGVSRS
                             ......  .. |. .|  . |. ||  .|. . . |... .              ..| .|||| |||.|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ATLCIAYLMKFH---NVCLLEAYNWVKARRPV-IRPNVGFWRQLIDYERQLF
.||..||||. .   .|.||||..... .||  . .| ...|.|......|.
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0049772 (Phosphotyrosine protein) phosphatases II 46-188 8.9e-34 113.0 In-house 164-297 (314) alignment 
Range on Protein: 46-188
Range on HMM: 164-297/314.0
HLLQargitcivnaTI--EIPNFNWPQFEYVKVPLADmPHAPIGLYFDTVADKIHSVsRKHGATLVHCAAGVSRSAT-LCIAYLMKFHNVCLLEAYNWVK
 ||.          ..  . . |  . ..|. .|. | ..||.  .|| . . |... .|.|..||||.||..|..| ...||||| ..|.| ||...|.
ellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

ARRPvIRPNVGFWRQLIDYERQLFG-KSTVKMVQTPYGIVPDVYEKE
..|| |.|| ||..||..|| .|   .  .|.... |..........
lkRp.inpnpgfieqleqyefilealleylkflkkfyeyleenlldg
0043147 (Phosphotyrosine protein) phosphatases II 32-166 1.3e-33 111.5 In-house 24-161 (172) alignment 
Range on Protein: 32-166
Range on HMM: 24-161/172.0
SSLFLGRGSVASNRHLLQARGITCIVNATiE----IPNFNWPQFEYVKVPLADMPHApIGLYFDTVADKIHS--VSRKHGATLVHCAAGVSRSATLCIAY
  ....|  .|.....|. .|||.|||.| |     ...    ..|  .|  |..   .  ... . . |..  . ...|..|||| |||.|..||..||
atqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMKfHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
||. ... |.||...|...|| . .| ...|.| ..|..|.
lml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_DSP8_pd Subfamily DSP8 26-166 1.6e-33 109.5 In-house 14-155 (159) alignment 
Range on Protein: 26-166
Range on HMM: 14-155/159.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFN-WPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
|. .|.  |.||   .. ...||.. ||. ..||  . |. .  .. ....||. |  .  .  .||.  . |  . ...|  |||. || |||||. ||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|.||  .. | |||..|| .||.| ||. |  ||..||..| 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP3_pd Subfamily DSP3 28-166 3.9e-32 105.1 In-house 12-158 (162) alignment 
Range on Protein: 28-166
Range on HMM: 12-158/162.0
AQITSSLFLGRGSVASNRHLLQARGITCIVNATIE----I---PN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS-VSRKHGATLVHCAAGVSRS
 ... .|..|  .||.... |.. ||| ..||.      .   .. ..  ...|. ... |.|.. .  ||.|.|. |.. .|.|.|  ||||..|||||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ATLCIAYLMKFHNVCLLEAYNWVKARRPvIRPNVGFWRQLIDYERQLF
||| .|||| .... | || . |...|  |.|| || .||......| 
atlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk
0049260 (Phosphotyrosine protein) phosphatases II 30-165 4.6e-32 106.2 In-house 11-149 (152) alignment 
Range on Protein: 30-165
Range on HMM: 11-149/152.0
ITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPN---FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHS-VSRKHGATLVHCAAGVSRSATLCIAY
..  ...|. ..|.. ..|.  |||.||. | . ..   . .  ..|  .|  |..  ..  ... . . |.    .|.| .|||| |||.|..||..||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMKfHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
||. ..| |.||...|...||.. || |..|.| ..|..|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-167 3.7e-31 102.2 In-house 122-260 (263) alignment 
Range on Protein: 29-167
Range on HMM: 122-260/263.0
QITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKV-PLADMPHAPIGLYFDTVADKIHSvSRKHGATLVHCAAGVSRSATLCIAYLM
.|   ||||    | |. .|.  |.| |. |  ..  .    | |. .  . |...| |  .|. .   |..  ||.|  |||| ||||||.|| |.|||
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafiee.GrkkGGvlvhcraGvsrsstlvisylm

KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFG
| ... . ||.. |. .|| |.|| ||  ||  ||..|| 
kkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_DSP12_pd Subfamily DSP12 27-164 4.4e-31 102.4 In-house 2-142 (155) alignment 
Range on Protein: 27-164
Range on HMM: 2-142/155.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIE-IPNFN--WPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCI
. .|.  |.||  . . . .||.  .|| ..  . | .|...  . . .. .....|.|...|  ..|.. | |..   ..|| ||||.||||||.|..|
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
||||| ... | .|.. ||. .| |.|| || .||  .|. 
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_DSP15_pd Subfamily DSP15 26-164 1.4e-30 100.4 In-house 1-138 (151) alignment 
Range on Protein: 26-164
Range on HMM: 1-138/151.0
GIAQITSSLFLGRGSVASNRHLLQARGITCIVNATiEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY
|| ..   |.||   ......||. . || |..   . ..   ...||  ....| |.| .  .|.   . ||.   | .. ||||.||||||.||..||
giskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQ
||   ..   .| . .||.| |  ||.|| ||| .||..
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0046846 (Phosphotyrosine protein) phosphatases II 22-167 2.2e-30 101.1 In-house 7-174 (176) alignment 
Range on Protein: 22-167
Range on HMM: 7-174/176.0
GDIGGIAQITSSLFLGRGS----------VASNRHLLQARGITCIVNATIEI-----------PNFNWPQFEYVKVPLADMPHAPIgLYFDTVADKIHSV
|. ... .|. .|.||             .|.. ..|.  |||..|| | |.           | .  ....|  .|  |.   ..  ..... . |...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

SRKHGATLVHCAAGVSRSATLCIAYLMKF-HNVCLLEAYNWVKARRP-VIRPNVGFWRQLIDYERQLFG
 ...| .|||| ||..|..||..|||..  ... ..||. .|...||  . .. ...|.| ..|..|..
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
0040439 (Phosphotyrosine protein) phosphatases II 39-166 2.6e-30 101.3 In-house 65-246 (249) alignment 
Range on Protein: 39-166
Range on HMM: 65-246/249.0
GSVASNRHLLQARGITCIVNATIEIPN-------------------------------------------FNWPQFEYVKVPLADMPHAPIGLYFDTVAD
..|......|.  |||.||..| . ..                                            . . ...  ..  |.|.  .  .|... |
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlld

KIHSVSR------KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 |. |        |.| .|||| |||.|..|...||||     | ..|.|.||..... .|| . .| ...|.|......|.
fieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 33-163 3e-30 98.7 In-house 14-145 (148) alignment 
Range on Protein: 33-163
Range on HMM: 14-145/148.0
SLFLGRGSVASNRHLLQARGITCIVNATIEIPN-FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
 ||||    |..   |.| |.| ||||| | .| ..    ||..|.|.| |.  .  .|..... .. .  . .  |||.  |||||. | ...|..|..
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYER
| | ||.. || .|. ..|| || .|| ..|.
vslkealalvkskrryvdpnlgfLkqLaeleq
0037934 (Phosphotyrosine protein) phosphatases II 30-166 5.7e-29 96.8 In-house 42-242 (243) alignment 
Range on Protein: 30-166
Range on HMM: 42-242/243.0
ITSSLFLGRG--------SVASNRHLLQARGITCIVNATIEI---------------------------------------------PNFNWPQFEYVKV
.|  |... |         .||. ..|.  |||.||. | ..                                             ... .  . |  .
vtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

PLAD----MPHAPIGLYFDTVADKIHS-----VSRKHGATLVHCAAGVSRSATLCIAYLMKFH-NVCLLEAYNWVKARRPV-IRPNVGFWRQLIDYERQL
|  |      ....  ..| | . |..     .  ..| .|||| |||.|..||..||||. . .| |.||.......||  . .. ...|.|......|
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel

F
.
l
subfamily_MKPLT_pd Subfamily MKPLT 32-168 1.4e-28 93.5 In-house 27-163 (164) alignment 
Range on Protein: 32-168
Range on HMM: 27-163/164.0
SSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
  |.||... | |...|..  || ||| . |  .     .|| .| . | ..  .. ... .|. . .     |  ||||  |.|||..  .|.|.|.. 
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  | |||...| || ...|| || .||  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 32-168 1.4e-28 93.5 In-house 27-163 (164) alignment 
Range on Protein: 32-168
Range on HMM: 27-163/164.0
SSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHN
  |.||... | |...|..  || ||| . |  .     .|| .| . | ..  .. ... .|. . .     |  ||||  |.|||..  .|.|.|.. 
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  | |||...| || ...|| || .||  .|. ..||
wtlkeayeylkerrsivapnrGflkqlakfeelilGk
PTEN_1 29-166 2.7e-28 94.1 In-house 43-192 (196) alignment 
Range on Protein: 29-166
Range on HMM: 43-192/196.0
QITSSLFLGRGSVA-SNRHLLQARGITCIVNATIEIPN---------FNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSR--KHGATLVHCAAGVS
.|  .|..|. . . .... |...|||..|| . | ..         |.  ..|| ..|  | .  ..   || ... |.....  .... ||||.||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
||.|...||||. ..    ||  .|...||...|| .....|. |...|.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0051082 (Phosphotyrosine protein) phosphatases II 27-162 4.3e-28 93.2 In-house 8-150 (151) alignment 
Range on Protein: 27-162
Range on HMM: 8-150/151.0
IAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQF------EYVKVPLADMPHAPIGLYFDTVADKIHSVSRK-HGATLVHCAAGVSRSA
. ..|. |... |  | .  ||.  ||..||| . | .. ..|..      |.. .|. |.|  .. |.||.|.. .. . .| .| .|||| ||..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TLCIAYLMKfHNVCLLEAYNWVKARRP-VIRPNVGFWRQLIDYE
||...|||. ..|.| ||.......|| |..|| .|. ||....
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 27-165 7.5e-28 92.8 In-house 12-169 (174) alignment 
Range on Protein: 27-165
Range on HMM: 12-169/174.0
IAQITSSLFLGRGSVAsNRHLLQARGITCIVNATIEIPN---------------FNWPQFEYVKVPLADMPHAPIGLyFDTVADKIHSVSRK--HGATLV
.  ||. |..| |  | . ..|.  |||..|. . |...               .    ..|...|  |.   ..   .... . ....  .  .| .||
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCAAGVSRSATLCIAYLMKFHNV-CLLEAYNWVKARR---PVIRPNVGFWRQLIDYERQL
|| |||.|..||..||||. .    | .|...|...|   | . .. ...|.| ..|..|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 29-166 1.2e-27 92.3 In-house 49-243 (245) alignment 
Range on Protein: 29-166
Range on HMM: 49-243/245.0
QITSSLFLGRGSVASNRH----LLQARGITCIVNAT------------------------------------------------IEIPNFNWPQFEYVKV
.||  .... |  ... .    .|.  |||.||. |                                                 . . ..  .. |. .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

PlaDMPHAPIGLYFDTVADKIHSVSR--KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
|  |.. ...  ... . . .... .  ..| .|||| |||.|..|...||||     | ..|.| ||. ... .|| .... ...|.|......|.
p..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 46-166 3.2e-27 91.5 In-house 125-304 (307) alignment 
Range on Protein: 46-166
Range on HMM: 125-304/307.0
HLLQARGITCIVNATIEIPN----------------------------FNWPQFEYVKVPLADM-----------------PHAPIGLYFDTVADKIHSV
..|.  |.|.||. | ....                              .. . . .... |.                 |.  .  .|... | |. |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

SR------KHGATLVHCAAGVSRSATLCIAYLMKFHN--------VCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 .      |.| .|||| |||.|..|...||||. .         |.||||.......|| . .| ...|.|......|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 30-165 1.6e-26 86.5 In-house 6-152 (154) alignment 
Range on Protein: 30-165
Range on HMM: 6-152/154.0
ITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQ---------FEYVKVPLADMPHAPIGLYFDTVADKIHSVS--RKHGATLVHCAAGVSRS
 .. |...    | |. .|| . |. |.|  | |.|    .         .||... | | ..  |   .| . . |..     ...  |||. .|||||
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrs

ATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
|.| |.|||.  .. | .|.  .|  |..|.|| || .||  .|..|
aallisylmdklkislslalellkdsryiikPnqGflkqleifekel
0039614 (Phosphotyrosine protein) phosphatases II 45-166 2.4e-25 85.0 In-house 118-289 (297) alignment 
Range on Protein: 45-166
Range on HMM: 118-289/297.0
RHLLQARGITCIVNATIEIPN--------------------------------------------FNWPQFEYVKVPlaDMPHAPIGLYFDTVADKIHSV
 ....  |.|.||. | ....                                            . . .| |.. |  |.   |.  ... . ......
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrea

SR---KHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 .   |.| .|||| |||.|..|...||||     | ..|..|||..... .|| .... ...|.|.|....|.
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0040438 (Phosphotyrosine protein) phosphatases II 44-168 2.5e-25 84.9 In-house 102-277 (317) alignment 
Range on Protein: 44-168
Range on HMM: 102-277/317.0
NRHLLQARGITCIVNATIEIPN---------------------------FNWPQFEYVKVPLADM----------------PHAPIGLYFDTVADKIHSV
  ....  |.|.||. | . ..                           .  . ... .... |.                |.  .  ..|.. | .. |
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

SRK----HGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFgK
 ..    .| .|||| |||.|..|...||||     | ..|.. ||.......|| . .. ...|.|.|...... |
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.k
0036941 (Phosphotyrosine protein) phosphatases II 49-173 5e-25 83.8 In-house 99-284 (297) alignment 
Range on Protein: 49-173
Range on HMM: 99-284/297.0
QARGITCIVNATIEIPNFN------WP----------------------------------------------QFEYVKVPLADMPH-APIGLYFDTVAD
   ..|.||. | ....        ||                                              .| | . |  ..|. . . | |   ..
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KIHSVSRKHGATLVHCAAGVSRSATLCIAYLM--------KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKM
|... ....| .|||| |||.||.|...|.||        | ..|..|||..... .|| . ......|.|.... .|. | ..|.
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_STYX_pd Subfamily STYX 28-173 7.7e-25 80.9 In-house 13-165 (166) alignment 
Range on Protein: 28-173
Range on HMM: 13-165/166.0
AQITSSLFLGRGSVASN--RHLLQARGITCIV------NATIEIPNFNwPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSA
 .|   ||||  | | .   . |. .||| ||      .|..  |||.  .| |. . .|| .   |  |. || . | .  .| |  |||  ||.||||
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfp.drfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKM
.| |||.|. . .   ||. .|. ||  | || || .|| .||   . | |.|.
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikl
0043336 (Phosphotyrosine protein) phosphatases II 45-165 9e-23 76.6 In-house 105-276 (278) alignment 
Range on Protein: 45-165
Range on HMM: 105-276/278.0
RHLLQARGITCIVNAT-----------------------------------------------IEIPNFNWPQFEYVKVPLADMPHaPIGLYFDTVADKI
.....  |.|.||. |                                                . . .   .. |...|  . |. .. |..| . . .
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavr

HSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
. .. ..|..|||| |||.|..|....||.     | ..|.|.||..... .|| . ..  ..|.|.......
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0051429 (Phosphotyrosine protein) phosphatases II 40-166 4.9e-22 74.3 In-house 34-225 (272) alignment 
Range on Protein: 40-166
Range on HMM: 34-225/272.0
SVASNRHLlQARGITCIVNATIEI-----P-NFNWPQFEYVKVPLADMPHAPIGLYF-------------------------------------------
..|. ..| .  ||..||. . |      .  . ||...|. .|. |. . .| ...                                           
taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpd

-----DTVADKIHSVSRkHGATLVHCAAGVSRSATLCIAYLMKfHNVC--------------LLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
     ... . .. . . .|. ||||.||..|..|.. ..|.  ..|.              |.||.....|.|| .... .....| .....|.
hgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0038934 (Phosphotyrosine protein) phosphatases II 47-167 3.5e-21 71.2 In-house 51-178 (194) alignment 
Range on Protein: 47-167
Range on HMM: 51-178/194.0
LLQARGITCIVNATIEIPNFNWPQF-----EYVKVPLADM---PHAPIGLYFDTVADKIHSVSrKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAY
 |. ........ | . . ..   |     ||.| |  |    |   | | |  ..|.... . ..|. .||| ||..|..||..|||.. ..  . ||.
kllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned.pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAi

NWVKARRPVIRPNVGFWRQLIDYERQLFG
.... .|| . ||......|  . ..|. 
alfrekRpgaipnqdyleallkrykelrk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 34-165 8.3e-21 67.6 In-house 6-141 (145) alignment 
Range on Protein: 34-165
Range on HMM: 6-141/145.0
LFLGRGSVASNRHLLQARGITCIVNAT----IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKF
|. | .  |..  .||  ||. ||| .    .   . .  ..| . .   |.    .  .|| |.| |     .    .||| |||||| |. .|.|||.
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQL
 |..| ||   |...|    ||| | ..|.. |.||
cnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_MSG5_pd Subfamily MSG5 56-168 9.9e-21 67.6 In-house 51-163 (165) alignment 
Range on Protein: 56-168
Range on HMM: 51-163/165.0
IVNATIEIPNF--NWPQFEYVKVPLADmpHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVG
..| . ||...    |  .| ..      .. | . . ...  ||.   |.   ||||  |.||||.| .||.||..|. | .||. .|..   | |..|
vinvakeindlellvpavkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsig

FWRQLIDYERQLFGK
.  ||...|  |  |
lifqlmewevalskk
subfamily_STYXL1_pd Subfamily STYXL1 31-168 1.1e-19 64.2 In-house 16-156 (157) alignment 
Range on Protein: 31-168
Range on HMM: 16-156/157.0
TSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFN--WPQ-FEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
 . |.||  . | |... .   .   || . .  ..   ...  . ..... | ..| .   .. . . |..  ..  . ||    |.||||.. |||||
PgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylm

KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGK
  ... | .||. .|  .. ..|| .|  || ..|.||.|.
yskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0047943 (Phosphotyrosine protein) phosphatases II 68-160 1.7e-17 59.3 In-house 168-266 (273) alignment 
Range on Protein: 68-160
Range on HMM: 168-266/273.0
WPQFEYVKVPLADMP-HAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGFWRQLID
  .| | . |  . | .  . | |  ...|... ....| ..||| |||.|..|.....|.     | ..|..|||..... .|| . ... ..|.|..
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 66-154 8.5e-15 50.4 In-house 182-274 (288) alignment 
Range on Protein: 66-154
Range on HMM: 182-274/288.0
FNWPQFEYVKVPlaDMPHAP-IGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNVGF
..  .| | . |  |.   . . |..| . . ... . ..| ..||| |||.|..|.....|.     | . | .|||..... .|| . ...  
rtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
subfamily_PTPMT1_pd Subfamily PTPMT1 71-166 1.6e-14 48.7 In-house 74-169 (171) alignment 
Range on Protein: 71-166
Range on HMM: 74-169/171.0
FEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLF
 |.....  |. .||         . |..|  |     ||| || .||||| ..|||| ... . || . .|..|. || .   |..|  ||..| 
veqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0046845 (Phosphotyrosine protein) phosphatases II 65-151 8.2e-14 47.1 In-house 164-259 (284) alignment 
Range on Protein: 65-151
Range on HMM: 164-259/284.0
NFNWPQFEYVKVPLADMPH-APIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFH--------NVCLLEAYNWVKARRPVIRPN
 .   .| | . |  . |. . . | |   ...... . ..| ..||| |||.|..|.....|.. .        .| .|||..... .||    .
srtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 70-152 1.7e-13 46.0 In-house 201-285 (308) alignment 
Range on Protein: 70-152
Range on HMM: 201-285/308.0
QFEYVKVPlaDMPHAPIGLYFDTVADKIHSVSrKHGATLVHCAAGVSRSATLCIAYLM-----KFHNVCLLEAYNWVKARRPVIRPNV
.| |   |  |.   |    . .  ......  ..| ..||| |||.|..|.....|.     | ..| ..||..... .||   ...
hfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0048567 (Phosphotyrosine protein) phosphatases II 89-162 2.4e-10 35.0 In-house 59-135 (157) alignment 
Range on Protein: 89-162
Range on HMM: 59-135/157.0
YFDTVADKIHSVSRKHGATLVHCAAGV---SRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYE
..  . ....... ...|  ||| ||    .|.|||. .||.. ..    ||.....  || . |    .  | .|.
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
PTPc_DSPc_SM00012 70-127 1e-08 30.7 In-house 4-62 (105) alignment 
Range on Protein: 70-127
Range on HMM: 4-62/105.0
QFEYVKVPLADMPH--APIGLYFDTVADKIHSVSRkHGATLVHCAAGVSRSATLCIAYLM
...| . |   .|.   .|  ... | .. .  .. .. ..||| |||.|..|.. ....
hyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldil
subfamily_CDC14_pd Subfamily CDC14 99-146 2.5e-08 28.2 In-house 258-305 (328) alignment 
Range on Protein: 99-146
Range on HMM: 258-305/328.0
SVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP
 . . .||  ||| ||. |  ||  .|||| ...   ||  |..  ||
iaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
subfamily_PTPN1_pd Subfamily PTPN1 70-124 2.7e-07 24.6 In-house 166-221 (290) alignment 
Range on Protein: 70-124
Range on HMM: 166-221/290.0
QFEYVKVPLADMPHAPIG-LYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIA
.| |.. |   .|..|   | |     .  |.|...| ...||.||. || |.|..
hfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv
subfamily_PTPDC1_pd Subfamily PTPDC1 70-146 1.1e-06 23.2 In-house 82-156 (182) alignment 
Range on Protein: 70-146
Range on HMM: 82-156/182.0
QFEYVKVPLADMPHAPIGLYFDTVadKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRP
.  . .....|   |..   .| |  |. . . ..|.. ||| ||  |   |  .||.  ...   .| . |...||
giyvynfgwkDygvasleriLdiv..kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
Y_phosphatase Protein-tyrosine phosphatase 69-127 1.2e-06 23.5 Pfam-A 136-193 (235) alignment 
Range on Protein: 69-127
Range on HMM: 136-193/235.0
PQFEYVKVPLADMPHAPIGLYfdTVADKIHSVS-RKHGATLVHCAAGVSRSATLCIAYLM
 |. | . |  ..|  | .|    . .|... .  |.| ..||| |||.|..|.. . ..
kqlhytnWpdhgvpespksll..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 69-127 1.2e-06 23.5 In-house 136-193 (235) alignment 
Range on Protein: 69-127
Range on HMM: 136-193/235.0
PQFEYVKVPLADMPHAPIGLYfdTVADKIHSVS-RKHGATLVHCAAGVSRSATLCIAYLM
 |. | . |  ..|  | .|    . .|... .  |.| ..||| |||.|..|.. . ..
kqlhytnWpdhgvpespksll..dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
subfamily_DSP23_pd Subfamily DSP23 47-147 1.4e-06 23.0 In-house 26-127 (148) alignment 
Range on Protein: 47-147
Range on HMM: 26-127/148.0
LLQARGITCIVNATIEIPNF--NWPQFEYVKVPLADMpHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKAR
 |   |.  .|  | | .      |.  .|.. . |. | |     .     ..    |  |  |||. |  |. |.   ||.| ....  ||   |. .
ylldlgvrylvslteegrphveatpnltlvrlriddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RPV
|| 
rpg
subfamily_PTPN6_pd Subfamily PTPN6 70-123 1.8e-06 22.2 In-house 190-246 (306) alignment 
Range on Protein: 70-123
Range on HMM: 190-246/306.0
QFEYVKVPLADMPHAPIGL--YFDTVADKIHSVS-RKHGATLVHCAAGVSRSATLCI
|... . | ...|. |  .  ....|  | .... ...|...|||.||. |  |. .
qyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv
DSPc_SM00195 94-127 3.7e-06 21.8 In-house 185-218 (263) alignment 
Range on Protein: 94-127
Range on HMM: 185-218/263.0
ADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
    .| |...| ..||| |||.|..|.. . ..
ravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 94-127 3.7e-06 21.8 In-house 185-218 (263) alignment 
Range on Protein: 94-127
Range on HMM: 185-218/263.0
ADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLM
    .| |...| ..||| |||.|..|.. . ..
ravkkskstssgpivVhCsaGvgRtgtfvtidii
subfamily_Laforin_pd Subfamily Laforin 73-148 4.1e-06 19.8 In-house 79-154 (183) alignment 
Range on Protein: 73-148
Range on HMM: 79-154/183.0
YVKVPLADMPHA-PIGLYFDTVaDKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVI
|. .|. |.     .    ..|   .|..  |     ||| ||| ||...   .|.   .  |      . |.|||.
yiwlptedlstesrvenlpqav.yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPRA_pd Subfamily PTPRA 69-145 8.6e-06 19.8 In-house 194-271 (330) alignment 
Range on Protein: 69-145
Range on HMM: 194-271/330.0
PQFEYVKVPLADMPHAPIGLYfDTVAdKIHSVSRKH-GATLVHCAAGVSRSATLCI--AYLMKFHNVCLLEAYNWVKARR
 || .   |   .|  |||.  . .. |.... ... |.  |||.||| |. |...  | | . .   ... .. ||  |
rqfhftswPdvGvPfepiGml.kllk.kvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlr
subfamily_PTPRD_pd Subfamily PTPRD 70-142 9.8e-06 19.5 In-house 181-254 (564) alignment 
Range on Protein: 70-142
Range on HMM: 181-254/564.0
QFEYVKVPLADMPHAPIGLyFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAY--LMKFHNVCLLEAYNWVK
|| ... |  ..|. . .|  | . .  .. ....| ..||| ||| |. | ..    | . ..  ... |. ||
qFhFtsWPdhgvpesatsl.LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvk