Gene DUSP18 in Homo sapiens

Synonym: DSP18, DUSP20, LMWDSP20, bK963H5.1, DUSP18

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP017_AA protein Get Run
HsapP017_AA_17-162 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 15-170 2.5e-73 239.2 In-house 2-156 (157) alignment 
Range on Protein: 15-170
Range on HMM: 2-156/157.0
PSVSGLSQITKSLYISnGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAAL
|....|||||.||..| ||||..| .|....||..|||.||..|| ..||....|||.|.|...|...||..||.|..|..|.|.||.||.|||||||.|
pelaalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAsl

CLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMVSSP
||||||||...|| .|....||.|||||||.|||.|||.|| .|.||..|.||.||
claylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp
subfamily_DSP1_pd Subfamily DSP1 21-159 1e-41 136.8 In-house 19-157 (163) alignment 
Range on Protein: 21-159
Range on HMM: 19-157/163.0
SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
 .|.  ||.     | |. .|.|..|| ..||| |. |.  .  .|..... |||.  .   |... ..|..|. |.|. |.||.||.|||..|||||||
ekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylm

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
| . .|| .|....|. |.||.|| ||  ||..|| .| 
ktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP10_pd Subfamily DSP10 20-159 2.4e-39 128.8 In-house 14-154 (159) alignment 
Range on Protein: 20-159
Range on HMM: 14-154/159.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYE-DIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
.||.   |.. ... |... .|   .||.|.||  .| |. .| ...|...|| |. .  |   |.   ..|. .  |. | |.|| ||.||||.. .||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
|||.  .|| ||. . |..|||| || .|  ||...| .| 
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP19_pd Subfamily DSP19 20-158 2.6e-39 129.0 In-house 12-150 (152) alignment 
Range on Protein: 20-158
Range on HMM: 12-150/152.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYL
.......||..   .|..| .|....|| ..||...|.|.  .|..|..... | |. .|..... . | |...  |.|. |.|| |||||||.. .|||
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
|| . .|| .| .  .. || |.||.||..|| .|| .|
mkkeelsleealelvrearpcikPneGFikqLkeyeael
PTPc_motif_SM00404 20-156 4.5e-39 128.5 In-house 2-139 (140) alignment 
Range on Protein: 20-156
Range on HMM: 2-139/140.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNT-LYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
 |.|.. ||...  .|.|. .|....||.||||. ||..|   ...|..|.|. |. .. |....| ..| |...| |.|. | ||.|||||||.|..||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEF
||.|. .|| .|    |. ||||.|| .|..||| || 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 17-163 2.6e-38 126.8 In-house 20-175 (178) alignment 
Range on Protein: 17-163
Range on HMM: 20-175/178.0
VSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYED---------IQYMQVPVADSPNSRLCDFFDPIADHIHSVE-MKQGRTLLHCAA
  ..|.|.  ||...  .|... .|  . ||...|.. |. .  ...         |||...|. |...  | ..|. . . |...   |.|..| || |
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsa

GVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPiIRPNSGFWEQLIHYEFQLFGKNT
||.||..|..|||||.. .|| .|  . ...|| | || |...||. .| .|.....
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
DSPc Dual specificity phosphatase, catalytic domain 27-156 1.3e-35 117.2 Pfam-A 1-132 (133) alignment 
Range on Protein: 27-156
Range on HMM: 1-132/133.0
LYISNGVAANnKLMLSSNQITMVINVSVEVVN---TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYH
||...  .|. . .|. ..||.||||. || |      ..|.|...|| |. .. ...... . . |...| |... | ||.||.||||.|..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

AMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEF
 .|| .|    |. |..|.|| ||. ||. || 
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 27-156 1.3e-35 117.2 In-house 1-132 (133) alignment 
Range on Protein: 27-156
Range on HMM: 1-132/133.0
LYISNGVAANnKLMLSSNQITMVINVSVEVVN---TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYH
||...  .|. . .|. ..||.||||. || |      ..|.|...|| |. .. ...... . . |...| |... | ||.||.||||.|..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

AMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEF
 .|| .|    |. |..|.|| ||. ||. || 
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 19-157 4.2e-34 111.8 In-house 1-138 (151) alignment 
Range on Protein: 19-157
Range on HMM: 1-138/151.0
GLSQITKSLYISNGVAANNKLMLSSNQITMVINVSvEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAY
|.|.. . ||..|   .... .|. ..|| ...|. .  . | .||.|  ....|.|.  |  ||.   . ||.  .|..  |.||.||||||. |. ||
giskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQ
||    ..  || .  | .| .  || || .|| .|| .
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0048076 (Phosphotyrosine protein) phosphatases II 20-159 1.1e-33 111.3 In-house 4-143 (145) alignment 
Range on Protein: 20-159
Range on HMM: 4-143/145.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYL
 |.|. .||...  .|..  .| ...||.|.|.. |  .   ..|||...|. | .   | .... . . |...  . |..| || |||.|...|..|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
|... .|| .|  . .|.||.. || |....|. .| .|.
mlllgvsleealelvrsqrpgavpnpgqlrflyefelell
0041856 (Phosphotyrosine protein) phosphatases II 19-164 1.4e-33 111.4 In-house 18-178 (182) alignment 
Range on Protein: 19-164
Range on HMM: 18-178/182.0
GLSQITKSLYISNGVA--------------ANNKLMLSSNQITMVINVSvEVV----NTLYEDIQYMQVPVADSPNSRlcdfFDPIADHIHSVEMKQGRT
.|..|. .||...  |              |..  || ...||...|.. |.     .   . |||...|. | .       .| . | |. |. ..|..
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpv

LLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRP--IIRPNSGFWEQLIHYEFQLFGKNTV
| || |||.|...|..|||||.. .|| .|  . .|.||  .|.|| .|..||. .|..|..|...
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_DSP8_pd Subfamily DSP8 18-158 7.8e-33 107.3 In-house 13-154 (159) alignment 
Range on Protein: 18-158
Range on HMM: 13-154/159.0
SGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVN-TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCL
 |. .|.| ||.   . . .. .|| . |..|.|.| . ..    .. ....||| |. . .| ..||   . |  .  ..|| |.|. || ||||.. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
||.||.  ||| .|... |. || | ||  | .||..|| .|
ayimktlemsldeayrfvkekrptispnlnflgqLleyekel
0048179 (Phosphotyrosine protein) phosphatases II 20-156 2e-32 107.2 In-house 4-142 (144) alignment 
Range on Protein: 20-156
Range on HMM: 4-142/144.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDI--QYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLA
 |.|. .||...  .|..  .| ...||.|||.. |  .. .|.   ||...|. | .   | .... . . |...  . |..| || |||.|...|..|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEF
||||.. .|| .|  . .|.||.. || |....|. || 
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0045098 (Phosphotyrosine protein) phosphatases II 12-160 3e-32 107.5 In-house 14-273 (278) alignment 
Range on Protein: 12-160
Range on HMM: 14-273/278.0
FRQPSVSGLSQITKSLYISNGV-----------------------------------------AANNKLMLSSNQITMVINVS-----------------
..... .  |.|| .||..|.                                          .|..  || ...|| ....                  
efllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

-----------------------------------VEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEM--------------KQGRTLLHC
                                    .  .   . ..|. .|  ..|.. . ..|. . . |...                ..|..| ||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

AAGVSRSAALCLAYLMKYH---AMSLLDAHTWTKSCRPI-IRPNSGFWEQLIHYEFQLFG
 |||.|...|..||||...    ..||.| .. .|.||. . .| .....|.... .|. 
saGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Slingshot_pd Subfamily Slingshot 21-159 4.9e-32 104.6 In-house 20-158 (169) alignment 
Range on Protein: 21-159
Range on HMM: 20-158/169.0
SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
|.| . .|.     | |   |..|... ..||. |. |   |...|... | |.... | ....   ..|. .  |. . |.||  ||||||.  .|| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
| . .|| .|... |. | .|.||.||..|| .||  | 
keyglsleealeyvkerrsvikPnkgflkqleeyeGile
subfamily_DSP3_pd Subfamily DSP3 20-159 5.7e-32 104.6 In-house 11-158 (162) alignment 
Range on Protein: 20-159
Range on HMM: 11-158/162.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVE------VVNTLYE--DIQYMQVPVADSPNSRLCDFFDPIADHIHS-VEMKQGRTLLHCAAGVSR
. .....||...  .|..|  |    || |.| .          .  |.  .|.|. ..| |.|.. |  .|.. |..|.. .. |.|. |.||..||||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SAALCLAYLMKYHAMSLLDAHTWTKSCRPIiRPNSGFWEQLIHYEFQLF
||.| ||||| .. |.| .| .  .. | | .||.|| .||.... .| 
satlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelk
subfamily_DSP12_pd Subfamily DSP12 21-155 2.3e-31 103.3 In-house 3-140 (155) alignment 
Range on Protein: 21-155
Range on HMM: 3-140/155.0
SQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVV---NTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLA
|.|.. ||...  |.... .|.. .|| |. |  | .   ..    ... .....|.|.  . ...| . |.|..   ..|  | ||.||||||.....|
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
||||.. .|| .|.   |. .| |.|| || |||  .|
YlmkkeklslekAlklvkekkpeiepNegFleQLklfe
subfamily_DSP6_pd Subfamily DSP6 20-158 7.6e-31 100.8 In-house 14-154 (158) alignment 
Range on Protein: 20-158
Range on HMM: 14-154/158.0
LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLY--EDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLA
. .|.. ||. .  .|.|  .|.  .|  |.||  .. |.    ....|.|.|. |  .  |  ||    . |     |.   |.|| ||.||| ...||
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
||||..|.|| ||. . |. .. | ||  | .||...| .|
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_MKPLT_pd Subfamily MKPLT 24-161 3e-30 98.9 In-house 26-163 (164) alignment 
Range on Protein: 24-161
Range on HMM: 26-163/164.0
TKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYH
 . ||  |.  |.|. .|   .|| ..||| |  .   . ..|.|| | | ....| .|.. .|. . .     || |.||  |.|||..  .|.|.|..
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

AMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGK
   | .|. . |  | |..|| ||  || ..|  ..||
gwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 24-161 3e-30 98.9 In-house 26-163 (164) alignment 
Range on Protein: 24-161
Range on HMM: 26-163/164.0
TKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYH
 . ||  |.  |.|. .|   .|| ..||| |  .   . ..|.|| | | ....| .|.. .|. . .     || |.||  |.|||..  .|.|.|..
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

AMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGK
   | .|. . |  | |..|| ||  || ..|  ..||
gwtlkeayeylkerrsivapnrGflkqlakfeelilGk
0049772 (Phosphotyrosine protein) phosphatases II 35-159 8.5e-30 99.9 In-house 160-274 (314) alignment 
Range on Protein: 35-159
Range on HMM: 160-274/314.0
ANNKLMLSsnqitmvinvsvEVV--NTLYED--IQYMQVPVADsPNSRLCDFFDPIADHIHSVeMKQGRTLLHCAAGVSRSA-ALCLAYLMKYHAMSLLD
| .  .|             |..  . |.|.  |.|...|| | ..  | ..|| . ..|...  |.|..| ||.||..|.. ....|||||.. .|| .
aadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvslee

AHTWTKSCRPiIRPNSGFWEQLIHYEFQLF
|  . ...|| |.|| ||.|||..|||.| 
aledvrlkRp.inpnpgfieqleqyefile
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 22-158 1.4e-29 96.5 In-house 5-152 (154) alignment 
Range on Protein: 22-158
Range on HMM: 5-152/154.0
QITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYED---------IQYMQVPVADSPNSRLCDFFDPIADHIHSVE--MKQGRTLLHCAAGVSR
. .  ||||   || ||| |  ..|. ..||.. . | . ..         |.|... . | .|  . . .|   . |..    ..... |.|. .||||
keaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsr

SAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
|||| ..|||.   .||  |    |..|.||.|| || .||  .| .|
saallisylmdklkislslalellkdsryiikPnqGflkqleifekel
0037934 (Phosphotyrosine protein) phosphatases II 20-159 3.5e-29 97.5 In-house 39-242 (243) alignment 
Range on Protein: 20-159
Range on HMM: 39-242/243.0
LSQITKSLYISNG--------VAANNKLMLSSNQITMVINVSVEV---------------------------------------------VNTLYEDIQY
|...|. |....|        ..|..  || ...||.....  .|                                              .  ...|.|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

MQVPVAD----SPNSRLCDFFDPIADHIHS-----VEMKQGRTLLHCAAGVSRSAALCLAYLMKYH-AMSLLDAHTWTKSCRPI-IRPNSGFWEQLIHYE
...|. |    .  . | ||.| . ..|..     .. ..|..|.|| |||.|...|..||||...  ..|..|  . ...||  . .. .....|....
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

FQLF
 .|.
lell
0043147 (Phosphotyrosine protein) phosphatases II 27-158 3.6e-28 93.8 In-house 26-160 (172) alignment 
Range on Protein: 27-158
Range on HMM: 26-160/172.0
LYISNGVAANNKLMLSSNQITMVINVSvE----VVNTLYEDIQYMQVPVADSPNSrLCDFFDPIADHIHS--VEMKQGRTLLHCAAGVSRSAALCLAYLM
..  .   | .  || ...||...|.  |      .   ..|||. .|. | .   | .... . . |..  .. ..|..| || |||.|...|..||||
qgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

KyHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
. . .||..|  . ...||.. .| ... .| ..| .|
l.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 27-155 7.6e-28 90.9 In-house 15-144 (148) alignment 
Range on Protein: 27-155
Range on HMM: 15-144/148.0
LYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYE-DIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAM
|.. .   | .  .|    .| ..| . |  |.| .  |.|..|...| |.  |  .|..|.. .. .. . .| |.|.  |||||.|| |..|.... .
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
|| .|    || |. ..|| || .|| ..|
slkealalvkskrryvdpnlgfLkqLaele
0046846 (Phosphotyrosine protein) phosphatases II 19-160 1.4e-27 91.9 In-house 11-174 (176) alignment 
Range on Protein: 19-160
Range on HMM: 11-174/176.0
GLSQITKSLYISNGV----------AANNKLMLSSNQITMVINVSVEV-------VNTLYE----DIQYMQVPVADSPNSRLcDFFDPIADHIHSVEMKQ
.|..|. .|....             |..  || ...||.|.|.  ||        |   |    .|||...|. |     | . .. . . |...  . 
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

GRTLLHCAAGVSRSAALCLAYLMKY-HAMSLLDAHTWTKSCRP-IIRPNSGFWEQLIHYEFQLFG
|..| || ||..|...|..|||... . .|...|  . ...||  . .. .....| ..| .|..
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_LRR-DSP_pd Subfamily LRR-DSP 21-162 3e-27 89.4 In-house 121-262 (263) alignment 
Range on Protein: 21-162
Range on HMM: 121-262/263.0
SQITKSLYISNGVAANNKLMLSSNQITMVInVSVEVVNTLYEDI-QYMQV-PVADSPNSRLCDFFDPIADHIHSVEmKQGRTLLHCAAGVSRSAALCLAY
..| . |..    .|||| .| ....| .. ..|  .. |. .. .|. .  . | ..  .  .|. .   |..   |.|  |.|| ||||||..| ..|
deiidklflGgldsannksilkdlgvthil.lavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsstlvisy

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKN
|||.. . . .|   ... || |.|| || .||  || .||  |
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctn
PTEN_1 10-158 7.1e-27 89.5 In-house 31-191 (196) alignment 
Range on Protein: 10-158
Range on HMM: 31-191/196.0
VQFRQPSVSGLSQITKSLYISNGVAA-NNKLMLSSNQITMVINVSVEVVN-----TLY----EDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEM--KQ
. .. ||...|..| ..||. .   . ... .| .. ||.|.|.| |  .     .|.    ....| ..|. | . . |  .|| ... |...    ..
amgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpng

GRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
.  | ||.||..||. .. ||||... ..  .|  . ...|| ..|||...|.|..|. .|
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0040439 (Phosphotyrosine protein) phosphatases II 33-160 9.4e-27 89.6 In-house 66-247 (249) alignment 
Range on Protein: 33-160
Range on HMM: 66-247/249.0
VAANNKLMLSSNQITMVINVSVEVVN-------------------------------------------TLYEDIQYMQVPVADSPNSRLCDFFDPIADH
  ...  ||  ..||...... .| .                                              |......... | |   ....|... | 
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IHSVEM------KQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFG
|. |.       |.|..| || |||.|......||||     |.. ..|..|  . .|.|| . .| .....|. ....|. 
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0036282 (Phosphotyrosine protein) phosphatases II 18-158 2.9e-26 87.6 In-house 10-169 (174) alignment 
Range on Protein: 18-158
Range on HMM: 10-169/174.0
SGLSQITKSLYISNGVAAnNKLMLSSNQITMVINVSVEVVNT---------------LYEDIQYMQVPVADSPNSRLCDfFDPIADHIHSVEMK--QGRT
 .|| ||. |....| .| .  || ...||.|...  |. .                  ..|||...|. |     |   .. . . ....  .  .| .
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

LLHCAAGVSRSAALCLAYLMKYHAM-SLLDAHTWTKSCR---PIIRPNSGFWEQLIHYEFQL
| || |||.|...|..||||... . || ||  . ...|   | . .. .....|  .| .|
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0049260 (Phosphotyrosine protein) phosphatases II 24-155 3.5e-26 87.1 In-house 12-146 (152) alignment 
Range on Protein: 24-155
Range on HMM: 12-146/152.0
TKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNT---LYEDIQYMQVPVADSPNSRLCDFFDPIADHIHS-VEMKQGRTLLHCAAGVSRSAALCLAYL
.  ... .  .|... || ...|| ....  .. ..    .. |||...|. |..   | .... . . |.   . |.|..| || |||.|...|..|||
iatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MKyHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
|. . .||..|  . ...||.. || |....|  .|
ml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0045450 (Phosphotyrosine protein) phosphatases II 39-159 1.9e-25 85.7 In-house 125-304 (307) alignment 
Range on Protein: 39-159
Range on HMM: 125-304/307.0
LMLSSNQITMVINVSVEVVNTL----------------------------YEDIQYMQVPVADS-----------------PNSRLCDFFDPIADHIHSV
 ||  ...|...... .| ..                             ..........| |.                 |.  ....|... | |. |
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

EM------KQGRTLLHCAAGVSRSAALCLAYLMKYHA--------MSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
.       |.|..| || |||.|......||||...         ..||.|  . ...|| . .| .....|......|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 19-159 3.3e-25 84.4 In-house 46-243 (245) alignment 
Range on Protein: 19-159
Range on HMM: 46-243/245.0
GLSQITKSLYISNGVAANNKL----MLSSNQITMVINVSVEV----------------------------------------------VNTLYEDIQYMQ
....||. .....| ....      || ...||...... |.                                               .   |.|.|..
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

VPVADSPNSRLCDFFDPIADHIHSVEM--KQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLF
.|. | .   | . .. . . ....    ..|..| || |||.|......||||     |.. .|| .|  . .|.|| .... .....|......|.
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 19-154 7.7e-25 82.7 In-house 7-149 (151) alignment 
Range on Protein: 19-154
Range on HMM: 7-149/151.0
GLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYE------DIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMK-QGRTLLHCAAGVSRS
 .|..|  ||.|.|  | .  .| ...|....|.  |. .  .       .|.....|. | |.  | ..|| ... .. .. | .| .| || ||..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

AALCLAYLMKyHAMSLLDAHTWTKSCRP-IIRPNSGFWEQLIHY
..|...|||. . .|| .|  . ...|| ...|| .|. ||...
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYXL1_pd Subfamily STYXL1 25-161 5.2e-23 75.0 In-house 17-156 (157) alignment 
Range on Protein: 25-161
Range on HMM: 17-156/157.0
KSLYISNGVAANNKLMLSSNQITMVINVSVE---VVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMK
. ||. |   | |. .    ..  ..||| .   ..... .  . ....| |.... | .... . . |.. . ..   |.    |.|||||. .|||| 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGK
.. ..| .|..  | |.. ..|| .| ||| ..| ||.|.
skkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0036941 (Phosphotyrosine protein) phosphatases II 43-167 1.8e-22 75.5 In-house 100-285 (297) alignment 
Range on Protein: 43-167
Range on HMM: 100-285/297.0
SNQITMVINVSVEVVNTL-------------------------------YED---------------------IQYMQVPVADSPnsrlcDFFDPIADHI
 ...|...... .| .                                 ..|                     ..|.  |  . |     . .... | |
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvp.....espaslldfi

HSVEM------KQGRTLLHCAAGVSRSAALCLAYLM--------KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMV
. |.       ..|..| || |||.||.....|.||        |.. ...|.|  . ...|| . .. .....|......|. |... . 
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
0040438 (Phosphotyrosine protein) phosphatases II 40-162 7.6e-22 73.4 In-house 105-278 (317) alignment 
Range on Protein: 40-162
Range on HMM: 105-278/317.0
MLSSNQITMVINVSVEVVN----------------------------TlYEDIQYMQVPVADS----------------PNSRLCDFFDPIADHIHSVEM
|.  ...|.....  .. .                            . ...|.. ...| |.                |   . . .|.. | .. |. 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

K----QGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFgKN
.    .| .| || |||.|......||||     |.. ... .|  . ...|| . .. .....|. ...... |.
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.kr
0039614 (Phosphotyrosine protein) phosphatases II 40-161 9.9e-21 69.9 In-house 120-291 (297) alignment 
Range on Protein: 40-161
Range on HMM: 120-291/297.0
MLSSNQITMVINVSVEVVNTL------------------------------------------YEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEM--
|.  ...|.....  .| .                                            ..  ..  ..  |     . . .. . . ....    
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-KQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGK
 |.|..| || |||.|......||||     |.. ...|.|  . ...|| .... .....|......|. .
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_STYX_pd Subfamily STYX 23-165 3.5e-20 65.7 In-house 15-164 (166) alignment 
Range on Protein: 23-165
Range on HMM: 15-164/166.0
ITKSLYISNGVAA-NNKL-MLSSNQITMVINVS----VEVVN-TLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALC
|   |..    || . || .| .. || .. .      ...   . ....|. . |||..   .  ..  . . | .   | |. |.|  ||.|||||| 
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

LAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVH
.||.|. . .   .|... .  |  | ||.|| .|| .||   . | |..
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltik
0038934 (Phosphotyrosine protein) phosphatases II 27-158 1.5e-19 65.8 In-house 38-176 (194) alignment 
Range on Protein: 27-158
Range on HMM: 38-176/194.0
LYISNGVAANNKLMLSSNQITMVINVSVE-----VVNTLYEDIQYMQVPVADS---PNSRLCDFFDPIADHIHSvEMKQGRTLLHCAAGVSRSAALCLAY
||  .     . | |   ....||... .     .      .|.|.. |. |    |.  . . |  ..|.... | ..|  . || ||..|.. |. ||
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaY

LMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
|.... ||. .|  . ...|| . || ...|.|  .  .|
LiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_MSG5_pd Subfamily MSG5 47-158 2.3e-18 59.8 In-house 49-160 (165) alignment 
Range on Protein: 47-158
Range on HMM: 49-160/165.0
TMVINVSVEVVNT--LYEDIQYMQVPVadSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPN
 .||||. |. .   |   ..|  .      .|...  .  ..  ||. . |. . |.||  |.||||.| .||.|||...|| ||.   ||    | |.
dlvinvakeindlellvpavkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

SGFWEQLIHYEFQL
 |.  ||. .|  |
iglifqlmeweval
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 27-158 2.6e-18 59.5 In-house 6-141 (145) alignment 
Range on Protein: 27-158
Range on HMM: 6-141/145.0
LYISNGVAANNKLMLSSNQITMVINVSVE----VVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKY
||.  .. ||.  .|    |. ..|..        ..  |.|. . .   |     | . || ..| |     .    ..|| |||||| .. .|.||||
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
 .|.| .|    .| |    ||  |  .|.. | ||
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0051429 (Phosphotyrosine protein) phosphatases II 23-159 1.1e-17 60.0 In-house 20-225 (272) alignment 
Range on Protein: 23-159
Range on HMM: 20-225/272.0
ITKSLYISNGV---AANNKLMLSSNQITMVINVSVEVVNTLY------EDIQYMQVPVADSPNSRLC---------------------------------
. . || |.|     |..   | ...|......  |.    .      ..|.|...|. |.   .                                   
kpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------DFFDPIADHIHSvemkQGRTLLHCAAGVSRSAALCLAYLMKyHAMS--------------LLDAHTWTKSCRPIIRPNSGFW
                  . .  . .....    .|. | ||.||..|.. .....|.  . .|              |..|  . ...|| .... ...
revmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

EQLIHYEFQLF
..| ... .|.
lflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 43-158 1.5e-17 59.5 In-house 110-276 (278) alignment 
Range on Protein: 43-158
Range on HMM: 110-276/278.0
SNQITMVINVSVEVV-----------------------------------------------NTLYEDIQYMQVPVADSPNsRLCDFFDPIADHIHSVEM
 ...|.....  .|                                                      ..|. .|  . |   | ...| . . .. .| 
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealed

KQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
..| .| || |||.|.......||.     |.. ..|..|  . ...|| . ..  ....|.......
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0047943 (Phosphotyrosine protein) phosphatases II 64-153 2.3e-14 49.0 In-house 171-266 (273) alignment 
Range on Protein: 64-153
Range on HMM: 171-266/273.0
IQYMQVPVADSP-NSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIH
..|.  |  . | .   .  |  .......  ...| .. || |||.|........|.     |.. ...|.|  . .|.|| . ..  ....|..
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
subfamily_PTPMT1_pd Subfamily PTPMT1 63-158 2.7e-14 48.0 In-house 73-168 (171) alignment 
Range on Protein: 63-158
Range on HMM: 73-168/171.0
DIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQL
.....|... |  ..   .      . |..|  |. |  .|| || .|||.|  .|||| . .|. .|..  |..|.||| ..  |..| .|| .|
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0051299 (Phosphotyrosine protein) phosphatases II 64-145 1.1e-12 43.5 In-house 182-272 (288) alignment 
Range on Protein: 64-145
Range on HMM: 182-272/288.0
IQYMQVPVADSPNSRLC----DFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPNS
.....  . . |.        ...| . . ... . ..| .. || |||.|........|.     | . ...|.|  . ...|| . .. 
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 64-144 8e-12 40.6 In-house 202-284 (308) alignment 
Range on Protein: 64-144
Range on HMM: 202-284/308.0
IQYMQVPVADSPNS--RLCDFFDPIADHIhsvemKQGRTLLHCAAGVSRSAALCLAYLM-----KYHAMSLLDAHTWTKSCRPIIRPN
..|.  |  . |.|   | ||.. . ...     ..| .. || |||.|........|.     | . .....|  . ...||   ..
fhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 63-141 1.4e-11 39.8 In-house 169-256 (284) alignment 
Range on Protein: 63-141
Range on HMM: 169-256/284.0
DIQYMQVPVADSP--NSRLCDFFDPIADHIHSvEMKQGRTLLHCAAGVSRSAALCLAYLMKYH--------AMSLLDAHTWTKSCRPII
 ..|.. |  . |   . | .|.. . ... .   ..| .. || |||.|........|....         ...|.|  . ...||  
hfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0048567 (Phosphotyrosine protein) phosphatases II 62-155 5.2e-11 37.1 In-house 37-135 (157) alignment 
Range on Protein: 62-155
Range on HMM: 37-135/157.0
EDIQYMQVPVADSPN--SRLCDFFDPIADHIHSVEMKQGRTLLHCAAGV---SRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYE
....|.     . |   ..| .|.  . . ....|.. ..  .|| ||    .|.| |. .||.... ..  .|  . . .|| . |    .  | .|.
dglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
subfamily_CDC14_pd Subfamily CDC14 89-139 7.6e-08 26.6 In-house 255-305 (328) alignment 
Range on Protein: 89-139
Range on HMM: 255-305/328.0
HIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRP
 .. .|  .|   .|| ||. |  .|  .|||| . ..  .| .| . |||
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
PTPc_DSPc_SM00012 64-123 8.9e-08 27.7 In-house 5-65 (105) alignment 
Range on Protein: 64-123
Range on HMM: 5-65/105.0
IQYMQVPVADSPNSRlcdffDPIADHIHSVEMKQG------RTLLHCAAGVSRSAALCLAYLMKYH
..|.. |    |..      |.| .....|. ..        ...|| |||.|.. .......  .
yhytgwpdhgvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
subfamily_Laforin_pd Subfamily Laforin 61-141 2.1e-06 20.8 In-house 72-154 (183) alignment 
Range on Protein: 61-141
Range on HMM: 72-154/183.0
Y--EDIQYMQVPVAD-SPNSRLCDFFDPIaDHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPII
|  | . |. .|. | | .||.  . . .   .|..  |  .  .|| ||| ||.|.   .|.     ||        . ||..
ykeeglayiwlptedlstesrvenlpqav.yllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPN23_pd Subfamily PTPN23 60-119 8.5e-06 19.8 In-house 176-234 (288) alignment 
Range on Protein: 60-119
Range on HMM: 176-234/288.0
LyEDIQYMQVPVADSPnSRLCDFFDPIADHIHSVEMKQGR-TLLHCAAGVSRSAALCLAYL
| .  .. .. | .|| . | .|.| . .. ..|. |     ..|| ||| |. ...| | 
l.qltsWpelGvPasP.etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvya
Y_phosphatase Protein-tyrosine phosphatase 62-124 9.8e-06 20.5 Pfam-A 136-197 (235) alignment 
Range on Protein: 62-124
Range on HMM: 136-197/235.0
EDIQYMQVPVADSPNSrlcdfFDPIADHIHSVEMKQ----GRTLLHCAAGVSRSAALCLAYLMKYHA
. ..| . |  . |.|      ... | |..|| ..    | .. || |||.|.. .... ..  ..
kqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql
Y_phosphatase Protein-tyrosine phosphatase 62-124 9.8e-06 20.5 In-house 136-197 (235) alignment 
Range on Protein: 62-124
Range on HMM: 136-197/235.0
EDIQYMQVPVADSPNSrlcdfFDPIADHIHSVEMKQ----GRTLLHCAAGVSRSAALCLAYLMKYHA
. ..| . |  . |.|      ... | |..|| ..    | .. || |||.|.. .... ..  ..
kqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql