Gene DUSP28 in Homo sapiens

Synonym: DUSP26, VHP, DUSP28

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP019_AA protein Get Run
HsapP019_AA_16-161 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 17-162 2.9e-55 180.5 In-house 5-149 (157) alignment 
Range on Protein: 17-162
Range on HMM: 5-149/157.0
PPLVRVAPSLFLGsARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTA
. |....|||||. ..|| ..|.|.....||..||....| ..........||| |.|...| .|........|.. ..||..||.|..|.||||..|.|
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQSC
|||... |||..|...||||||. .|| |||.||..||..|...| 
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss
0044763 (Phosphotyrosine protein) phosphatases II 15-160 8.2e-36 118.7 In-house 19-173 (178) alignment 
Range on Protein: 15-160
Range on HMM: 19-173/178.0
VPPPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPG---------VAELRVPVFDDPAEDLLAHLEPTCAAMEAAV-RAGGACLVYCK
 ....... | |.|||. .|   |.| . |.|. ||..  ..... .          .  |..|. |... |||.|.. .....|.|. . ||..||.|.
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

NGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPvAEPNPGFWSQLQKYEEALQAQ
 |..||.... ||||...|||| .|...|...|| . ||||.. ||...|. |...
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_DSP19_pd Subfamily DSP19 20-158 2.8e-35 115.9 In-house 13-151 (152) alignment 
Range on Protein: 20-158
Range on HMM: 13-151/152.0
VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLM
. | |.|.|||  .| ..|.| . ..|  .||. . |   .  .  | ....|.| .|||..|. .   .| | .. || || |. |.||||.|  ||||
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQ
... ||| .|...|..||| ..|| ||. ||..||. |.
kkeelsleealelvrearpcikPneGFikqLkeyeaell
subfamily_DSP12_pd Subfamily DSP12 20-156 2.1e-34 113.2 In-house 3-142 (155) alignment 
Range on Protein: 20-156
Range on HMM: 3-142/155.0
VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQP---GPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTA
 |. | |.||...|.  ||.|. ...|  . | ...     ...  |... ....|.| ||.| ||. ... .| |.  .|| || |. | |||.....|
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA
|||.. .||| ||...||...| .||| || .||. .|. 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
PTPc_motif_SM00404 20-155 5.9e-34 112.0 In-house 3-139 (140) alignment 
Range on Protein: 20-155
Range on HMM: 3-139/140.0
VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGP-RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYL
 |. | |.|||...|  ...|.  |.|...||..... .   .|.  |..|. |.  ..|...|. . . .|.| . ||..||.|. | ||||....|||
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

MRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE
|| |.||||.|...||. ||  .|| .|. ||..||.
mryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 17-160 2.4e-33 109.5 In-house 16-159 (163) alignment 
Range on Protein: 17-160
Range on HMM: 16-159/163.0
PPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTA
 |  .. . |.|||.  |.  |.|.. |.|  .|||.. .          .... | | .|. ...|.    .... ...|  |..|. | |||...| |
dPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
|||... .|| .||..||. |.. .|| ||  || .||. |...
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
0048076 (Phosphotyrosine protein) phosphatases II 19-157 6.2e-33 108.9 In-house 4-142 (145) alignment 
Range on Protein: 19-157
Range on HMM: 4-142/145.0
LVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYL
  .. |.|.|||  .|   |.|.. |.|. .|... .... . |.  |..|. | .. |||..|.  ....|.|...|| .||.|. |..|..... |||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
|...|.|| .|...|.|.|| | ||||.. .|...|. |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP10_pd Subfamily DSP10 17-161 9.5e-32 104.1 In-house 12-157 (159) alignment 
Range on Protein: 17-161
Range on HMM: 12-157/159.0
PPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAP-GVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCT
 |...| | |||||.. |  .. | | ..|  .||  . |   .  ..   |.|| |   ..|  . |   . .| | . |   ||.|. | ||||.|  
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

AYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQS
||||.|..||| .|...||..||.  || .|  || ..|. |. ..
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
DSPc Dual specificity phosphatase, catalytic domain 26-155 1.6e-31 103.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 26-155
Range on HMM: 1-132/133.0
LFLGSARAAGaEEQLARAGVTLCVNVSRQQPG---PRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHR
|.|||. .|  ...|.  |.|| .||... |       .   .||.|| |.  ... ..|| . . .|.| . |. .||.|. | ||||....||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE
.||| .|...||. |.   || ||. || .||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 26-155 1.6e-31 103.9 In-house 1-132 (133) alignment 
Range on Protein: 26-155
Range on HMM: 1-132/133.0
LFLGSARAAGaEEQLARAGVTLCVNVSRQQPG---PRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHR
|.|||. .|  ...|.  |.|| .||... |       .   .||.|| |.  ... ..|| . . .|.| . |. .||.|. | ||||....||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEE
.||| .|...||. |.   || ||. || .||.
nlslneAyefvkerrskispnagflrqLleyer
0048179 (Phosphotyrosine protein) phosphatases II 19-156 4e-31 103.0 In-house 4-143 (144) alignment 
Range on Protein: 19-156
Range on HMM: 4-143/144.0
LVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPR--APGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTA
 ... |.|.|||  .|   |.|.. |.|. .|.. . . .    .|.  |..|. | .. |||..|. .....|.|.. || .||.|. |..|......|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA
|||...|||| .|...|.|.|| | ||||.. .|..||. 
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_Slingshot_pd Subfamily Slingshot 22-160 6e-30 97.9 In-house 22-160 (169) alignment 
Range on Protein: 22-160
Range on HMM: 22-160/169.0
VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRH
.   ..|||   |   |.| . ||.  .||...     .  .. |.. |.|....|||.. . |   .|.| ..|  .||.|| | ||||..  || |..
ifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamke

RGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
 |||| .|.. ||. | |..||.||..||..||  |.|.
yglsleealeyvkerrsvikPnkgflkqleeyeGileas
PTEN_1 12-160 1.9e-29 97.8 In-house 35-194 (196) alignment 
Range on Protein: 12-160
Range on HMM: 35-194/196.0
ASPVPPPLvRVAPSLFLGSARAA-GAEEQLARAGVTLCVNVSRQQPGP---------RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVR--AGGAC
|. .|..  .. ..|..||.. .    ..|   |.|| ||.|   . .         .. ||  |..|. |..| .|  ...  . ..|.. .   |...
apsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvV

LVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
||.|| |..||. |. ||||....|.  .|...|...||.. ||.... .|..|.. |.|.
lVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 26-156 2.3e-29 95.8 In-house 15-146 (148) alignment 
Range on Protein: 26-156
Range on HMM: 15-146/148.0
LFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRA-PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGL
||||| . |   |.|.  |||  || ..... . .  |.  | |.. |.| ||| |  |.  | .. |. .|. .|| .. |.|||.|.  ..|....  
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA
|| .|...|||.|.  .||.|| .||...|.|
slkealalvkskrryvdpnlgfLkqLaeleqa
subfamily_DSP8_pd Subfamily DSP8 20-160 3e-29 95.6 In-house 16-157 (159) alignment 
Range on Protein: 20-160
Range on HMM: 16-157/159.0
VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRA-PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYL
 |. . |.||| . .  || | . |..  .|.|.. | .   . .  ||||| |.  |.||  .. ..  .. |... | .||..  |.||||.|  ||.
trilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayi

MRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
|..  .|| .|.. ||. ||. .||  |  || .||. |. .
mktlemsldeayrfvkekrptispnlnflgqLleyekelkll
0049772 (Phosphotyrosine protein) phosphatases II 54-160 2.3e-28 95.3 In-house 170-276 (314) alignment 
Range on Protein: 54-160
Range on HMM: 170-276/314.0
Q--QPGPRAPGVAELRVPVFDdPAEDLLAHLEPTCAAMEAAvRAGGACLVYCKNGRSRSA-AVCTAYLMRHRGLSLAKAFQMVKSARPvAEPNPGFWSQL
.  .. .  .|.  ||.|| | . ..||....  ....|.| ..||. || || |..|.. .|..||||...|.||..|...|...|| . |||||. ||
lydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieql

QKYEEALQAQ
. ||. |.|.
eqyefileal
0041856 (Phosphotyrosine protein) phosphatases II 18-157 8.2e-27 89.4 In-house 18-172 (182) alignment 
Range on Protein: 18-157
Range on HMM: 18-172/182.0
PLVRVAPSLFLGSARA--------------AGAEEQLARAGVTLCVNVSRQQPGPRAP---GVAELRVPVFDDPAEDllahLEPTCAAMEAAVRAGGACL
.| .. ..|.||| .|              |   ..| . |.|. ||..  .  |      |.  |..|. |... |    |. ... .|.. . ||..|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARP--VAEPNPGFWSQLQKYEEAL
| |. |..|..... ||||...|.|| .|...|.|.||  |  || .|. ||. .|. |
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_DSP6_pd Subfamily DSP6 19-160 2.1e-26 86.3 In-house 14-157 (158) alignment 
Range on Protein: 19-160
Range on HMM: 14-157/158.0
LVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGP--RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTA
.|.. | |.||||..|   | |.. ..   .||  . |     .. .  |..|. |   ..| ...  . . .. | ..  ..||.|  | ||| .|. |
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
|||... ||| .|...||. ..   ||  |  || ..|. |. .
ylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
subfamily_DSP15_pd Subfamily DSP15 21-157 4.7e-26 85.7 In-house 4-139 (151) alignment 
Range on Protein: 21-157
Range on HMM: 4-139/151.0
RVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRqQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMR
.| | |.||  | .  ||.| .  .|  ..|.  .. .  . .  . ... | |  .|  ... .   . ..   ....||.|  | |||. ...|||| 
kvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

HRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
   |.  .|....| || ||.|| || .||..||.. 
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
0043147 (Phosphotyrosine protein) phosphatases II 20-157 1.1e-25 85.7 In-house 20-160 (172) alignment 
Range on Protein: 20-157
Range on HMM: 20-160/172.0
VRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQ---QPGPRAPGVAELRVPVFDDPAEdLLAHLEPTCAAMEA--AVRAGGACLVYCKNGRSRSAAVC
 |. . .....   |   ..| . |.|. ||. .     ..    |.  |..|. | ..  ||..|. ..  ..   |.. ||..|| |. | .|.....
drfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

TAYLMRhRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
 ||||. .|||| .|...|...|| | .||... .|...|. |
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 15-158 3.8e-25 84.1 In-house 8-173 (176) alignment 
Range on Protein: 15-158
Range on HMM: 8-173/176.0
VPPPLVRVAPSLFLGSAR----------AAGAEEQLARAGVTLCVNVSRQQ-----------PGPRAPGVAELRVPVFDDPAEDLlAHLEPTCAAMEAAV
 ...|... ..|.|||.            |   |.| ..|.|. ||.   .           |  ...|.  |..|. |  . || ..|.  ..... |.
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

RAGGACLVYCKNGRSRSAAVCTAYLMRH-RGLSLAKAFQMVKSARP-VAEPNPGFWSQLQKYEEALQ
..||  || |. |..|..... |||... .|||. .|...|.. ||  | ..|... .|...|  |.
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 16-156 2.5e-24 81.3 In-house 9-168 (174) alignment 
Range on Protein: 16-156
Range on HMM: 9-168/174.0
PPPLVRVAPSLFLGSARAAgAEEQLARAGVTLCVNVSRQQPGP---------------RAPGVAELRVPVFDDPAEDLLAhLEPTCAAMEAAVRA--GGA
|  |... | |..|.. .|   |.| . |.|  |.. . ..                 .  |.  |..|. |. . ||   |.  . ..| |.    || 
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

CLVYCKNGRSRSAAVCTAYLMRHRGL-SLAKAFQMVKSAR---PVAEPNPGFWSQLQKYEEA
.|| |. |..|..... |||| ...| || .|...|...|   | . ..|... .|...|  
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_DSP3_pd Subfamily DSP3 22-160 3.2e-24 79.4 In-house 14-160 (162) alignment 
Range on Protein: 22-160
Range on HMM: 14-160/162.0
VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQP-----GP---RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRA-GGACLVYCKNGRSRSAA
| |.|..| . .|  ...|...|.|  .| .. .      |.   .  ..  | ..| | |. || .. |.. . ...|.    |  || |. | ||||.
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

VCTAYLMRHRGLSLAKAFQMVKSARPVAePNPGFWSQLQKYEEALQAQ
.  |||| .| ..| .| . |.. | .  || ||  ||....| |. .
lvlayLmirrkmtlveairtvrkkReil.PneGFlkqLaeldeelkrk
subfamily_MKPLT_pd Subfamily MKPLT 22-156 2.6e-23 76.3 In-house 25-159 (164) alignment 
Range on Protein: 22-156
Range on HMM: 25-159/164.0
VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRH
.   |.|| |  |  |. |    .|  ||||...    .  |  |.| | | . | | ..|| .   .  |. .||  ||.|  |.|||..|  |.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA
.|  | .|.. .|  | .. || ||  || |.|| 
kgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 22-156 2.6e-23 76.3 In-house 25-159 (164) alignment 
Range on Protein: 22-156
Range on HMM: 25-159/164.0
VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRH
.   |.|| |  |  |. |    .|  ||||...    .  |  |.| | | . | | ..|| .   .  |. .||  ||.|  |.|||..|  |.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEA
.|  | .|.. .|  | .. || ||  || |.|| 
kgwtlkeayeylkerrsivapnrGflkqlakfeel
0049260 (Phosphotyrosine protein) phosphatases II 22-157 7.8e-23 76.3 In-house 11-149 (152) alignment 
Range on Protein: 22-157
Range on HMM: 11-149/152.0
VAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPR---APGVAELRVPVFDDPAEDLLAHLEPTCAAMEA-AVRAGGACLVYCKNGRSRSAAVCTAY
. . ...|.  .|   ..| . |.|  |.. . .. ..   . .   |..|. |... ||  .|.  . ..|  | . || .|| |. | .|..... ||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMRhRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
||. .|.|| .|...|...||.| ||||.. .|...|. |
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0042113 (Phosphotyrosine protein) phosphatases II 14-154 1.3e-22 75.9 In-house 44-239 (245) alignment 
Range on Protein: 14-154
Range on HMM: 44-239/245.0
PVppPLVRVAPSLFLGSARAAGAEE----QLARAGVTLCVNVSRQ----------------------------------------------QPGPRAPGV
.|  .. |. | ...... ...  |    .| . |.|  |....                                               . ..   ..
yv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevi

AELRVPVFDDPAEDLLAHLEPTCAAMEAAVR--AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
  ...|. |... |||..|.  . ... |..  ..| .|| |. |..|......||||     ...|.|| .|.....| || | ..|... .|....
hyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 15-156 4.7e-22 74.1 In-house 18-270 (278) alignment 
Range on Protein: 15-156
Range on HMM: 18-270/278.0
VPPPLVRVAPSLFLGSAR-----------------------------------------AAGAEEQLARAGVTLCVNVSRQQPG----------------
....  .. |.|.||..                                          .|   ..|   |.|  |.. . ...                
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-----------------------------------PRAPGVAEL-RVPVFDDPAEDLLAHLEPTCAAMEAAVR--------------AGGACLVYCKNGR
                                   .|   .  .  .| .. | ...|...   .  ...|..               || .|| |. | 
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSAAVCTAYLMRHR---GLSLAKAFQMVKSARPV-AEPNPGFWSQLQKYEEA
.|..... ||||...   |..| .|.....| ||  | .|.... .| ...  
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0037934 (Phosphotyrosine protein) phosphatases II 17-154 1.2e-21 72.8 In-house 37-238 (243) alignment 
Range on Protein: 17-154
Range on HMM: 37-238/243.0
PPLVRVAPSLFLGSA--------RAAGAEEQLARAGVTLCVNVSRQQ---------------------------------------------PGPRAPGV
  |..| | |.....        ..|   . | . |.|  |.. . .                                             ...   ..
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

AELRVPVFD----DPAEDLLAHLEPTCAAMEA-----AVRAGGACLVYCKNGRSRSAAVCTAYLMRHR-GLSLAKAFQMVKSARPV-AEPNPGFWSQLQK
  ...|. |    |  ||||..|. ... .|.     |   || .|| |. |..|......|||| .. |..| .|...... ||  | ..|... .|..
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

YE
..
al
subfamily_LRR-DSP_pd Subfamily LRR-DSP 22-158 1.8e-20 67.1 In-house 123-259 (263) alignment 
Range on Protein: 22-158
Range on HMM: 123-259/263.0
VAPSLFLGSARAAGAEEQLARAGVTLC-VNVSRQQPgpRAPGVAE-LRV-PVFDDPAEDLLAHLEPTCAAMEAAVRAGGaCLVYCKNGRSRSAAVCTAYL
. . ||||.  .|  .  |   |||   . |.  .|    | .   | .  . | .  |.  |.| | | .|   . ||  ||.|. | |||...  .||
iidklflGgldsannksilkdlgvthillavadfeP..lfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

MRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQ
|... | . .|. .|.. ||   |||||  ||.|||. | 
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0040439 (Phosphotyrosine protein) phosphatases II 39-154 2.7e-20 68.5 In-house 73-242 (249) alignment 
Range on Protein: 39-154
Range on HMM: 73-242/249.0
QLARAGVTLCVNVSRQQPG-------------------------------------------PRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVR-
.| . |.|  |.... ..                                               . .  | ....| |  ..  ..|.... .||.   
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
      || .|| |..| .|......||||     ...|..|  |.....|.|| | .||... .|....
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
subfamily_STYXL1_pd Subfamily STYXL1 25-158 3e-20 66.0 In-house 18-154 (157) alignment 
Range on Protein: 25-158
Range on HMM: 18-154/157.0
SLFLGSARAAGAEEQLARAGVTLCVNVSRQQpGPRAPG----VAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMR
 |.||  . |  ..      |   |||| .  ..   |    . .|...| |..  ||| .|.  .  .|  .. | . ||. ..| ||||||  |||| 
klylGnykqaqnpaikkdlkvkahvnvsmda.dkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

HRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQ
.. ..| ||.. .|  ..  .|| .| .||...|. | 
skkitlkkaykylkkCkenvkPnrafveqlseWekqll
0045450 (Phosphotyrosine protein) phosphatases II 43-154 3.7e-19 65.0 In-house 130-300 (307) alignment 
Range on Protein: 43-154
Range on HMM: 130-300/307.0
AGVTLCVNVSRQQPGPR----------------------------APGVAELRVPVFDD-----------------PAEDLLAHLEPTCAAMEAAVR---
 |||. |....  .  |                             .|.  ....| |                  |  ..  ..|.... .|.. .   
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

---AGGACLVYCKNGRSRSAAVCTAYLMRHRG--------LSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
    || .|| |. | .|......|||| ...        ..| .|...... || | .||... .|....
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0051082 (Phosphotyrosine protein) phosphatases II 19-154 1e-18 62.8 In-house 8-150 (151) alignment 
Range on Protein: 19-154
Range on HMM: 8-150/151.0
LVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGP------RAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRA-GGACLVYCKNGRSRSA
. .| . |.....  |   |.|.. |..  ||.   .. .      .. |.  |..|..|.|. .|  ...   ...|.. .  .| .||.|. |..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

AVCTAYLMRhRGLSLAKAFQMVKSARP-VAEPNPGFWSQLQKYE
... .|||  .|.||..|...... || |  || .|. ||. ..
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 66-157 1.2e-18 60.9 In-house 59-152 (154) alignment 
Range on Protein: 66-157
Range on HMM: 59-152/154.0
LRVPVFDDPAEDLLAHLEPTCAAMEAAV--RAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
|.. .|||.  |.. .|. .   .. |.     .  ||....| |||||.  .||| .. .|| .|....|..|.. .|| ||  ||...|  |
lnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifekel
0051429 (Phosphotyrosine protein) phosphatases II 20-156 4.1e-18 61.5 In-house 17-223 (272) alignment 
Range on Protein: 20-156
Range on HMM: 17-223/272.0
VRVAPSLFLGSAR----AAGAEEQLARAGVTLCVNVSRQQPGPRAP------GVAELRVPVFDDPAEDLLAHL---------------------------
 .| | ... |..     |   ..|.. |..  |.. .    .| .      |.  |..|..|| |.. | .                            
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------EPTCAAMEAAVRaGGACLVYCKNGRSRSAAVCTAYLMRhRGLS--------------LAKAFQMVKSARPVAEPNPGFW
                     |. ....|.  . ||..|| |. |..|.. |. ..|.  .|.|              |..| ......|| | ......
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

SQLQKYEEA
 .|.... .
lflyealle
subfamily_STYX_pd Subfamily STYX 22-159 1e-17 57.7 In-house 15-159 (166) alignment 
Range on Protein: 22-159
Range on HMM: 15-159/166.0
VAPSLFLGSARAAG--AEEQLARAGVTLCVNVsRQQP-----GPRAPG-VAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAV
. | ||||   ||     |.| . |.|  | . ||..      |  |     | . | |.. |... .|  . . .. ... ||  ||. . | |||||.
ilpglflgpysaamksklevlkkhgithivci.rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

CTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQA
  ||.|   ||   .||..|.  |   .|| || |||..||    |
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
0039614 (Phosphotyrosine protein) phosphatases II 68-154 1.7e-17 59.3 In-house 191-285 (297) alignment 
Range on Protein: 68-154
Range on HMM: 191-285/297.0
VPVFDDPAEDLLAHLEPTCAAMEAAVR---AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
..  |. . ..|..|   . ... |..    || .|| |..| .|......||||     ...|... .|.......|| | ..|... .|....
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0040438 (Phosphotyrosine protein) phosphatases II 50-154 2.4e-17 58.7 In-house 116-272 (317) alignment 
Range on Protein: 50-154
Range on HMM: 116-272/317.0
NVSRQQPGP---------------------------RAPGVAELRVPVFDD----------------PAEDLLAHLEPTCAAMEAAVRA----GGACLVY
.. .  .                               .|.  ....| |.                |  ..  ....  . .||. .|    || .|| 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVH

CKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
|..| .|......||||     ...|... .|.......|| | ..|... .| ...
CsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
subfamily_PTPMT1_pd Subfamily PTPMT1 61-158 4.5e-16 53.8 In-house 72-169 (171) alignment 
Range on Protein: 61-158
Range on HMM: 72-169/171.0
PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQ
 ||  |.... |   .  |..|| .   .|     |    | || ||.|||.. ..||| .. ||. .| ...|. |.  . .   |..||.||| |.
lgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0038934 (Phosphotyrosine protein) phosphatases II 67-157 5.3e-16 54.3 In-house 84-176 (194) alignment 
Range on Protein: 67-157
Range on HMM: 84-176/194.0
RVPVFDDPAEDLLAHLEPTCAAMEAAV--RAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEAL
. |. || .   |. |   . ...  .   .||...| || |..|.. .. |||. ..|.|. .| ......|| | ||......|.|. . |
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0036941 (Phosphotyrosine protein) phosphatases II 78-154 5.3e-15 50.9 In-house 183-273 (297) alignment 
Range on Protein: 78-154
Range on HMM: 183-273/297.0
LLAHLEPTCAAMEAAVR------AGGACLVYCKNGRSRSAAVCTAYLM--------RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
.  . ..  . .|.. .       ||  || |..| .||.....|.||        ...|... .|...... || | ...... .|  ..
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 69-154 9.3e-15 50.3 In-house 182-273 (278) alignment 
Range on Protein: 69-154
Range on HMM: 182-273/278.0
PVFDDPAEDLLAHLEPTCAAMEAAVR-AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYE
.. |. . . |..|   . |.  |..  .|. || |..| .|.......||.     ...|..| .|...... || | ..| .. .| ...
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_MSG5_pd Subfamily MSG5 88-161 8e-13 41.8 In-house 91-164 (165) alignment 
Range on Protein: 88-161
Range on HMM: 91-164/165.0
AMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQS
 . ||   .   ||.|. | ||||..  ||.|.. .||| .|....||     .|. |.  || ..| ||...|
iihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskks
0047943 (Phosphotyrosine protein) phosphatases II 79-151 9.1e-12 40.5 In-house 185-265 (273) alignment 
Range on Protein: 79-151
Range on HMM: 185-265/273.0
LAHLEPTCAAMEAAVR---AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQ
|..|   . ... | .    .|  .| |..| .|........|.     ...|... .|.....| || . ..| .. .| 
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 75-158 2.3e-11 37.0 In-house 59-142 (145) alignment 
Range on Protein: 75-158
Range on HMM: 59-142/145.0
AEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQ
. ||  |..     ..     |   .|.|  | ||| .|  |.||.. ...|..| . |.| |  | ||  |  .| . |  |.
sydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0051299 (Phosphotyrosine protein) phosphatases II 83-144 8.6e-10 34.0 In-house 206-272 (288) alignment 
Range on Protein: 83-144
Range on HMM: 206-272/288.0
EPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNP
.   ....|    || ..| |..| .|........|.     ...|... .|...... || . ..|
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 90-144 2.4e-09 32.5 In-house 224-285 (308) alignment 
Range on Protein: 90-144
Range on HMM: 224-285/308.0
EAAVR--AGGACLVYCKNGRSRSAAVCTAYLM-----RHRGLSLAKAFQMVKSARPVAEPNP
|.. .   || ..| |..| .|........|.     ...|... .|...... || . ..|
elvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 89-144 5.6e-09 31.3 In-house 194-260 (284) alignment 
Range on Protein: 89-144
Range on HMM: 194-260/284.0
MEAAVR---AGGACLVYCKNGRSRSAAVCTAYLMRHR--------GLSLAKAFQMVKSARPVAEPNP
.. . .    ||  .| |..| .|........|. ..        |... .|...... || .  ..
vrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0048567 (Phosphotyrosine protein) phosphatases II 95-166 4.3e-08 27.7 In-house 73-145 (157) alignment 
Range on Protein: 95-166
Range on HMM: 73-145/157.0
AGGACLVYCKNGR---SRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALqaQSCLQGE
||.|  |.|| |.   .|.| .. .||. | |.. ..|..... .||   | .  .  | .|.  |  . .|.| 
agkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl..ldvlyGl
subfamily_DSP23_pd Subfamily DSP23 40-139 8.4e-08 27.0 In-house 27-127 (148) alignment 
Range on Protein: 40-139
Range on HMM: 27-127/148.0
LARAGVTLCVNVSRQQPGP--RAPGVA--ELRVPVFDDPAEDLLAHLeptCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKS
|.  ||   | .. . . .   .|...  .||.. .  || . . ..      .| |   . |  |.|  || |. .. . ||...|.|. |.|   |. 
lldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvef...vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

ARPV
 || 
lrpg
subfamily_Laforin_pd Subfamily Laforin 61-140 8.4e-07 22.0 In-house 75-154 (183) alignment 
Range on Protein: 61-140
Range on HMM: 75-154/183.0
PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVA
 |.| . .|. |  .|  .  |  .   . | .  |    |.|. |  ||.|.   .|.   | ||||   .. . |||.
eglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPDC1_pd Subfamily PTPDC1 89-140 6.1e-06 20.8 In-house 108-158 (182) alignment 
Range on Protein: 89-140
Range on HMM: 108-158/182.0
MEAAVRAGgACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVA
.. |.. | .  |.|  |. |   . ..||. .. |. .|| ..|.| || .
vafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks