Gene DUPD1 in Homo sapiens

Synonym: DUSP27, FMDSP, DUPD1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP024_AA protein Get Run
HsapP024_AA_52-204 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP3_pd Subfamily DSP3 43-204 1.8e-78 255.8 In-house 5-161 (162) alignment 
Range on Protein: 43-204
Range on HMM: 5-161/162.0
RLFWkgspqyTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRW-NVDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHS
||..      ..|.||.||||.||||.| |...|.|.|.|||||||.||. .||||...|.|..|.|.|.|.|| |.||||..|..||.|||.|||....
rlls......kevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkeg

KILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQR
|.|||||.| |||||||||||||...||||.||..|.|.|..|||.||||||.|||..|....
kvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrkk
0044763 (Phosphotyrosine protein) phosphatases II 37-204 6.1e-44 145.1 In-house 5-174 (178) alignment 
Range on Protein: 37-204
Range on HMM: 5-174/178.0
GAFELERLFWKGSPQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWN--VDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDR
  . |. | .  . .|....|..| ||.|.  .| |.  |.. |.||..| ..   .  ... | ......|||. .  .| ...||. .|. . .||..
trvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

ALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQR
||.......|||| .|..||.|||.||||.. ...| .||..| . |.. ||.|.|.||.|....| ...
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkes
PTEN_1 40-203 3.7e-36 119.8 In-house 25-194 (196) alignment 
Range on Protein: 40-203
Range on HMM: 25-194/196.0
ELERLFWKGSPQYTH--VnEVWPKLYIGDEATA-LDRYRLQKAGFTHVLNAAHGRWN--VDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDR
  .|....|..  ..    |....||.| .  .  |. .|.. |.|.|.| ......  ..  .. .......|. .. .| .. .|| .|  .. ||. 
itsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiew

ALSDD-HSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQQ
.|||. . ..||||  |..||.|.| |||| .. .|  .|.. |.. | .. || .....|.|  ..| ..
llsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0048076 (Phosphotyrosine protein) phosphatases II 56-200 7.3e-34 111.9 In-house 5-142 (145) alignment 
Range on Protein: 56-200
Range on HMM: 5-142/145.0
NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAahgrwnvDTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSRSA
.|..|.||.|.  ||||. .|.. |.|.|||         . .... ...|||. .  .| ...||. ... . .||..||...  ..|||| .|..|..
seilpglylgslptaldlellkdlgittvlnl.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtg

TLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQL
|||.||||......| .|...| . | .. || |.|..|.|....|
tlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 55-200 3.2e-33 109.8 In-house 4-144 (144) alignment 
Range on Protein: 55-200
Range on HMM: 4-144/144.0
VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTGPDyyrdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSRS
..|..|.||.|.  ||||  .|.| |.|.|.| ...... . ..       |||. .  .| ...||. ... . .||..||...  ..|||| .|..|.
pseilpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRt

ATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQL
.|||.||||......| .|...| . | .. ||.|.|..|.|..|.|
gtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0041856 (Phosphotyrosine protein) phosphatases II 54-203 9.4e-33 108.7 In-house 18-175 (182) alignment 
Range on Protein: 54-203
Range on HMM: 18-175/182.0
HVNEVWPKLYIGDEAT--------------ALDRYRLQKAGFTHVLNAAhgrwNVDTGPDYYRDMDIQYHGVEADDLPTFDlsvfFYPAAAFIDRALSdD
. ......||.|.  .              | .   |.. |.|...|..    ..   |... .. |||. .  .| ...|    .. . .||...|. .
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.e

HSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC---VLPNRGFLKQLRELDKQLVQQ
. ..|||| .|..|..|||.||||......| .|...| . |.   . || .|. || .|...|...
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP19_pd Subfamily DSP19 54-200 1e-32 107.6 In-house 11-150 (152) alignment 
Range on Protein: 54-200
Range on HMM: 11-150/152.0
HVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVdtgpdyYrDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSR
.| || |.||.|   .| |.  |.. . ||.|| | |  ||      .   |..|  .|  |||  ||. ..  |  ||. |.| |   .||||  |.||
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv......f.pkdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSR

SATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQL
||..|.|||| .....| .|...| . | |. || ||.|||.|....|
sasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP1_pd Subfamily DSP1 50-203 1.7e-32 106.8 In-house 13-159 (163) alignment 
Range on Protein: 50-203
Range on HMM: 13-159/163.0
PQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwnvdTGPDYYRDmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILVHCVM
. |  |... . ||.| | .| ..  |.. | |..||...      . .....|   .|. .. .| |. |.|. |...  |||..  . . |.|.|| .
klydPvekildfLylGsetvasnleiLkslgitailnvsk......eldnvfed.lfeYkklkleDspkadislvfeeviefidevk.kknGkvlihCqa

GRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLVQQ
| |||.||.||||| .| ..| .| . | ..|  . || || .|| . .|.| ..
GisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP14_pd Subfamily DSP14 50-204 2.5e-32 106.0 In-house 2-148 (157) alignment 
Range on Protein: 50-204
Range on HMM: 2-148/157.0
PQYTHVNEVWPKLYIGdEATALDRYRLQKAGFTHVLNAAHgrwNVDTgpDYYRdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRaLSDDHSKILVHCVM
|........ |.|...  ..||..  |.|.. |...|..    .. .    ..  ||..  | ..| |. .|. .| ..|. |.  .. .. |.|||||.
pelaalsqitpsLfls.gvaalskellkkkkitliinvtv...elpn..tklk..diervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCva

GRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLVQQR
|.||||.|.||||| .. ..| .| ..| . |  . || || |||....|.| .. 
GvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
0049772 (Phosphotyrosine protein) phosphatases II 58-202 9.8e-32 106.3 In-house 151-275 (314) alignment 
Range on Protein: 58-202
Range on HMM: 151-275/314.0
VWPKLyigDEATALDRYRLQkagfthvlnaahgrwNVDTGPDYYRDMDIQYHGVEADDlPTFDLSVFFYPAAAFIDRAlsDDHSKILVHCVMGRSRSAT-
....    .| || |   |.               .. . |... .. |.|. .  .| ....|. .|. . .||..|  |.....|||| .|..|..| 
ldgng...neptaadlellk...............eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtf

LVLAYLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQ
.|.||||.. ...| .|...| . | . ||.||..||... ..| .
vvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilea
0043147 (Phosphotyrosine protein) phosphatases II 52-208 2.3e-31 104.2 In-house 16-168 (172) alignment 
Range on Protein: 52-208
Range on HMM: 16-168/172.0
YTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAhgrwNVDTGPDYYRDMDIQYHGVEADDLPTFdLSVFFYPAAAFIDR-ALSDDHSKILVHCVMG
| . ..... .. ... .| ..  |.. |.||..|.     .  . |... ...|||. .  .| ... |. ... .  |||. .. ... ..||||..|
yyipdrfiatqgplrntladfwrmlkelgithivnlt....ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaG

RSRSATLVLAYLMIhKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLVQQRRRSQ
 .|..|||.||||. ....| .|...| . |. . .| .....|....|.|........
vgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdsla
0036282 (Phosphotyrosine protein) phosphatases II 52-199 3.4e-30 100.4 In-house 9-168 (174) alignment 
Range on Protein: 52-199
Range on HMM: 9-168/174.0
YTHVNEVWPKLYIGDEATAlDRYRLQKAGFTHVLNAAHGRWNV--------DTGPDYYRDMDIQYHGVEADDLPTFDLSVfFYPAAAFIDRALSD-DHSK
. ......|.|..|.  .| . . |.. |.|.|..  . . .          . ........|||. .  .|  ..|||. .. .  |...|||. .. .
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

ILVHCVMGRSRSATLVLAYLMIHKDM-TLVDAIQQVAKNR----CVLPNRGFLKQLRELDKQ
.|||| .|..|..|||.||||..  . .||||.. |.. |    .. .. .....|....|.
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
PTPc_motif_SM00404 55-198 6e-30 99.0 In-house 2-139 (140) alignment 
Range on Protein: 55-198
Range on HMM: 2-139/140.0
VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHG-RWNvdtgpdyYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSR
.... |.||.| . .| ..  |.| |.|||.|..   ...       . . ..|.  .. ||  . .|| ..  ...||..|  ... |.|||| .| ||
psrilphlylgskskaqnpallkklgithvinvteevslt.......kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSR

SATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDK
||||..||||  . ..| .|.. | ..|  . || .|..|| |. |
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 56-198 8.3e-30 97.3 In-house 8-145 (148) alignment 
Range on Protein: 56-198
Range on HMM: 8-145/148.0
NEVWPK-LYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVD-TGpdyyrdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSR
 |...  |..|.   |.|  .|.. | |.. ||.. | |.            |.|  |. || | .||| .| ...||...|  |.  ..|||. ||.||
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr.......gieYlhvaldDkpkedlsaiFediiafvrka.kdeGrrvLvhlqmGvsr

SATLVLAYLMIHKDMTLVDAIQQVA-KNRCVLPNRGFLKQLRELDK
|. |.|..|. .|...| .|.. |  | | | || |||||| ||..
ssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0046846 (Phosphotyrosine protein) phosphatases II 53-202 1.3e-29 98.6 In-house 10-174 (176) alignment 
Range on Protein: 53-202
Range on HMM: 10-174/176.0
THVNEVWPKLYIGDEA----------TALDRYRLQKAGFTHVLNAAHG----RWNVDTGPDYYRDMDIQYHGVEADDLPTFDLsVFFYPAAAFIDRALSD
 ........|..|.            .| .  .|...|.|.|.|        |..... ........|||. .  .|  . ||   .. . .||..||..
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

DhSKILVHCVMGRSRSATLVLAYLMIH-KDMTLVDAIQQVAKNR--CVLPNRGFLKQLRELDKQLVQ
.  ..||||..|..|..|||.|||... |.... .|...| . |  ...........|.|  ..| .
g.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
0051082 (Phosphotyrosine protein) phosphatases II 51-196 4.7e-29 96.3 In-house 4-149 (151) alignment 
Range on Protein: 51-196
Range on HMM: 4-149/151.0
QYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVdTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMG
 |.. . |.. ||...  .| .   |.. |.....|      .  . |.|.....|... .  .| |...|...|  ...|.. .|.... ..|||| .|
dyinfsyvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

RSRSATLVLAYLMIhKDMTLVDAIQQVAKNR--CVLPNRGFLKQLREL
..|..|||..|||.  ...| .|.... . |  .| || .||.||..|
kgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP10_pd Subfamily DSP10 54-203 5.3e-29 95.1 In-house 13-156 (159) alignment 
Range on Protein: 54-203
Range on HMM: 13-156/159.0
HVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwnvdTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDdHSKILVHCVMGRSR
 . .| | |..|.|  | |   |.. . |.||| .       . | .... ...|. ... |  . .|.  |  | .||. | .   |..||||  | ||
pasqvlpfLflGsekdaadldaldrlnitavlnvtt......svPnefeeealkYkripvsDtskqnlkqyfeealefieearkk.gsrvLvhCqaGisr

SATLVLAYLMIHKDMTLVDAIQQVAKNRCVL-PNRGFLKQLRELDKQLVQQ
|||.|.|||| |....| || . | ..| .. || .|. || |..|.| ..
satvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP6_pd Subfamily DSP6 56-202 7.5e-28 91.0 In-house 15-156 (158) alignment 
Range on Protein: 56-202
Range on HMM: 15-156/158.0
NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRwnvdtgPDYYRDM-DIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDhSKILVHCVMGRSRS
 |. | ||.| . .| ..  |.| .  .||| .. .      |. .... ...|  . ..|  . .|. ||  | .||| | |.. ||.||||  | |||
veilpllylGsakdasnlevlkklkikyvlnvtsnl......pnkfeesgelkylqipiedhlsqnlakffPeaiefidearskk.skvlvhClaGisrs

ATLVLAYLMIHKDMTLVDAIQQVAK-NRCVLPNRGFLKQLRELDKQLVQ
 |..||||| .. ..| || . | | .  . ||  |..|| . ...|  
vtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP12_pd Subfamily DSP12 55-201 1e-27 91.4 In-house 2-144 (155) alignment 
Range on Protein: 55-201
Range on HMM: 2-144/155.0
VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWnvdtgPDYYRDM-DIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILVHCVMGRSR
|... |.||.|. ... .  .|.... ||||  .. .      |..  ..  ...  ....| |. |.  ..  | .||. || ... ..|||| .| ||
vsrilpglylggleavqeeellkelkithvlsvikeel.....pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSR

SATLVLAYLMIHKDMTLVDAIQQVA-KNRCVLPNRGFLKQLRELDKQLV
|.|.|.|||| .... | .|.. |  |.. . || |||.||.  .|  .
SvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
DSPc Dual specificity phosphatase, catalytic domain 62-198 1.5e-27 91.1 Pfam-A 1-132 (133) alignment 
Range on Protein: 62-198
Range on HMM: 1-132/133.0
LYIGDEATALdRYRLQKAGFTHVLNAAHGRW-NvdtgpDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSRSATLVLA
||.| . ||     |.| |.|.|.|...    |       . . .|.| ..  .|  . ..| ..  | .||..|  ... |.|||| .| ||||||..|
lylgskstas.lalleklgitlvinvtkevpnn.....naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliia

YLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDK
|||  | ..| .|.. | ..|  . || |||.||.|...
YlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 62-198 1.5e-27 91.1 In-house 1-132 (133) alignment 
Range on Protein: 62-198
Range on HMM: 1-132/133.0
LYIGDEATALdRYRLQKAGFTHVLNAAHGRW-NvdtgpDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSRSATLVLA
||.| . ||     |.| |.|.|.|...    |       . . .|.| ..  .|  . ..| ..  | .||..|  ... |.|||| .| ||||||..|
lylgskstas.lalleklgitlvinvtkevpnn.....naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliia

YLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDK
|||  | ..| .|.. | ..|  . || |||.||.|...
YlmktknlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 55-207 1.6e-27 90.4 In-house 2-146 (151) alignment 
Range on Protein: 55-207
Range on HMM: 2-146/151.0
VNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwnvdtGPDYYRdMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHsKILVHCVMGRSRS
...| | ||.|.   . |. .|..   ||.|.           .  ..  ||.|. ..|.| |  .|| ||  .  || .. . .. ..||||..| |||
iskvlpglylgnfrdskdeelLkeknithilsvhd.......nakkll.kdieYkciaasDtpsaklskffkesvefihkcRlkee.nvlvhClaGvsRs

ATLVLAYLMIHKDMTLVDAIQQVAKNRCV-LPNRGFLKQLRELDKQLVQQRRRS
.||| ||||   ..   ||.. . ..| |  || || .||.| .|. ... |..
vtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkq
0049260 (Phosphotyrosine protein) phosphatases II 52-199 1.8e-27 91.3 In-house 5-148 (152) alignment 
Range on Protein: 52-199
Range on HMM: 5-148/152.0
YTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTGPDYYRdmdiQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGR
| . .|... ...|.. .| .   |.. | |....     ..   . ..|     ||. .  .| .. ||| ... .  ||.... |.. ..||||. | 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGv

SRSATLVLAYLMIhKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQ
.|..|||.||||. ....| .|...| . | .. || |.|..| | .|.
gRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0045098 (Phosphotyrosine protein) phosphatases II 31-203 5e-27 90.4 In-house 3-274 (278) alignment 
Range on Protein: 31-203
Range on HMM: 3-274/278.0
EDYCTPGAFELERLFWKGSPqythvNEVWPKLYIGDEA-----------------------------------------TALDRYRLQKAGFTHVLNAAH
 .....   | |.|.. |.|     .|..| ||.|. .                                         .| .   |.. | |.......
alasldlllefefllllgip.....seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmlte

GRWN------------------------------------------V---DTGPDYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALS-------
   .                                          .   ...   .    ..|....  . |..... .|  .  ||..||.       
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------DDHSKILVHCVMGRSRSATLVLAYLMIHK---DMTLVDAIQQVAKNRC--VLPNRGFLKQLRELDKQLVQQ
      |.. ..|||| .| .|..|||.||||..     ..| .|.... . |.  ...| .....| |.  .|...
sslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0037934 (Phosphotyrosine protein) phosphatases II 23-199 2.1e-26 88.4 In-house 6-240 (243) alignment 
Range on Protein: 23-199
Range on HMM: 6-240/243.0
KMEEEGEEEDYCTPGAFELERLFWKGsPQYTHVN--EVWPKLYIGDE--------ATALDRYRLQKAGFTHVLNAAHGR---------------------
...|  ..  |..  ... .| ...|   | . |  .|.|.|....         ..| .   |.. |.|....  .                       
llpenlsknrysdilpydhsrvkleg.sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-------------------WNVDTGPDYYRDMDIQYHGVEADDLPT--FDLSVFFYPAAAFIDRA----LSDDHSKILVHCVMGRSRSATLVLAYLMIHK
                   .|.|... .. .. ..|...   . |.   ||  |.  . .||...      |.....||||..|..|..||..||||...
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

-DMTLVDAIQQVAKNRC--VLPNRGFLKQLRELDKQ
 ...| .|.... . |.  . ........|.|. ..
lgvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Slingshot_pd Subfamily Slingshot 52-207 1.8e-25 83.3 In-house 16-164 (169) alignment 
Range on Protein: 52-207
Range on HMM: 16-164/169.0
YTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwNVDtgpDYYRDmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGR
  .  ...  .|.| |  | .   |.. | ...|| ..   ..|   ... . ...|. .   | .. ||  ..  .  ||..|  ...||.|||| || 
ldsaskifdhvylGsewnasnleelkengveyilnvtk...eid...nffpe.kfeylnirvydeeetdllkywnetykfieka.kkkgskvlvhckmGv

SRSATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQQRRRS
||||. |.|| | . ...| .|.. | ..| .. ||.||||||.| .  |  ...| 
srsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrh
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 59-200 1e-23 77.4 In-house 7-152 (154) alignment 
Range on Protein: 59-200
Range on HMM: 7-152/154.0
WPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTGP--DYYRDMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRAL-SDDHSKILVHCVMGRSRSA
   |||.   .||..  ||.   ...|| . |  |. |    |    . |.|  .|  | . ||.   .  |  ||| |. . ...|.|||.  | ||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQL
.|...||| .. ..|  |.. . . |  . ||.||||||   .|.|
allisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 56-201 2e-23 76.8 In-house 121-259 (263) alignment 
Range on Protein: 56-201
Range on HMM: 121-259/263.0
NEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHgrwnvDTGPdYYRDMdIQYHGV-EADDLPTFDLSVFFYPAAAFIDRAlsDDHSKILVHCVMGRSRS
.|. .||..|   .| ..  |.. | ||.| |       |  | .. ..  .|  . ...| . .|.| .|    |||.     ..  .||||  | |||
deiidklflGgldsannksilkdlgvthillava.....dfeP.lfPkl.fkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGvsrs

ATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLV
.|||..||| .. ... .|.  | |.|  . ||.||..||.  .|.|.
stlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 61-203 2.6e-23 75.7 In-house 5-144 (145) alignment 
Range on Protein: 61-203
Range on HMM: 5-144/145.0
KLYIGDEATALDRYRLQKAGFTHVLNAAHGRwNVDTGPDYYRDMDIqyHGVEADDLPTFDLSVFFYPAAAFIDRAlSDDHSKILVHCVMGRSRSATLVLA
.||.|   .| |   ||. | . ..| | |   | .   . ....|    . |.|| ..|||  |   . |||.   .. . ..|||. | ||| |. .|
rlyvgsalhandvptlqelgisrivnmaags.lvasqelksesiei..llitaedlesydlsqhfdevtdfidkg.keegagvfvhcmagvsrsvtvsva

YLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLVQQ
.|| . .||| .| .||  ||    ||  |||.| .|.||| ..
flmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
subfamily_DSP8_pd Subfamily DSP8 54-203 1.3e-21 70.8 In-house 14-157 (159) alignment 
Range on Protein: 54-203
Range on HMM: 14-157/159.0
HVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGrwnvDTGPDYYRDMDiqYHGVEADDLPTFDLSVFFYPAAAFIDRALSdDHSKILVHCVMGRSR
 .... ..||.| .  .|..  |.| | ..|||| .     .  ..  ..    .. |   |  . .|. .|  .  |||.| |  ....|||.  |.||
gptrilknlylGsqkdvlseellsklgisyvlnasns....cpkleelkesk..flrvPvkDkydekllpwfdksvefidkaks.engrvlvhvlaGisr

SATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQQ
|||...||.| . .|.| .| . | . |  . ||  ||.|| | .|.| ..
satvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_MKPLT_pd Subfamily MKPLT 61-198 1.3e-21 70.8 In-house 28-158 (164) alignment 
Range on Protein: 61-198
Range on HMM: 28-158/164.0
KLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTgpdyyrdMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILVHCVMGRSRSATLVLA
.|| |.   | ..  |..   ||..| . .. .  .       . ..|  |. .| ..  || |.  || |.  |. |   ..|||||.|.|||..  .|
tlylGnakhatnekvlkdlkithivnvsqekkdafp.......ksveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsssvtva

YLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDK
.|.  |  || .| . . . | .| ||||||||| . ..
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 61-198 1.3e-21 70.8 In-house 28-158 (164) alignment 
Range on Protein: 61-198
Range on HMM: 28-158/164.0
KLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTgpdyyrdMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALsDDHSKILVHCVMGRSRSATLVLA
.|| |.   | ..  |..   ||..| . .. .  .       . ..|  |. .| ..  || |.  || |.  |. |   ..|||||.|.|||..  .|
tlylGnakhatnekvlkdlkithivnvsqekkdafp.......ksveYlqvkvedesdeqlssfleraakfladai.dsGGrvlvhcvqGksrsssvtva

YLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDK
.|.  |  || .| . . . | .| ||||||||| . ..
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
0042113 (Phosphotyrosine protein) phosphatases II 51-200 2.1e-21 71.9 In-house 38-242 (245) alignment 
Range on Protein: 51-200
Range on HMM: 38-242/245.0
QYTHVNEV-----WPKLYIGDEATALDRY----RLQKAGFTHVLNAAHGRWNVDT---------------------------------------GPDYYR
 | . . |     .||.....  .. .       |.. | |....      .                                           .|.. 
dyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddes

DMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALS-DDHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRE
 ..|.|| .  .| .. ||.  .  .  |...||. |.. ..|||| .|..|..|...||||      .....| .|.... . | .. .. .....|.|
revihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye

LDKQL
. ..|
allel
0040439 (Phosphotyrosine protein) phosphatases II 65-201 2.6e-21 71.8 In-house 63-246 (249) alignment 
Range on Protein: 65-201
Range on HMM: 63-246/249.0
GDEATALDRYRLQKAGFTHVLNAAHGRWN--------------------------VDTGPDY----------YRDMDIQYHGVEADDLPTFDLSVFFYPA
 .|... ..  |.. | |..... .   .                          |.. .||          | . .......   |.| .... .| ..
lpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedl

AAFIDRALS-----DDHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLV
 .||.....     ......|||| .| .|..|...||||      .....| .|.... . | .. .| .....| |. ..|.
ldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0038934 (Phosphotyrosine protein) phosphatases II 45-209 6.4e-21 70.3 In-house 21-185 (194) alignment 
Range on Protein: 45-209
Range on HMM: 21-185/194.0
FWKGSPQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDtgPDYYRDMDIQYHGVEADD---LPTFDLSVFFYPAAAFIDRAlsDDHS
   ..|   ....... ||  .  . .. ..|.. . ..|..  .     |  |... ...|.|.     |    |....   |. .. .. ..  | . 
iafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYd..peefekagieylklpfpddgtvPsleillrfldlvdeflne..dpgg

KILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQQRRRSQR
...|||..|..|..||| |||. . .|.. .||. ..  |  ..||...|..|..  |.| .. .....
vvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapek
0045450 (Phosphotyrosine protein) phosphatases II 77-201 9.2e-20 67.0 In-house 128-304 (307) alignment 
Range on Protein: 77-201
Range on HMM: 128-304/307.0
QKAGFTHVLNAA----------------------HGRWNVDTGPDYYrDMDIQYHGVEADDL-----------------PTFDLSVFFYPAAAFIDRALS
.. | |....                        .|.. | .   .. . ..... .|  ||                 | .... .| .. .||.....
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

-----DDHSKILVHCVMGRSRSATLVLAYLMIHKD--------MTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLV
     ......|||| .| .|..|...||||..          ..| .|.... . | .. .| .....|.|. ..|.
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 82-201 1.7e-18 62.4 In-house 104-277 (297) alignment 
Range on Protein: 82-201
Range on HMM: 104-277/297.0
THVLNAAHGR----------WNVD-TGPDYYRDMDIQYHGVEA-----------------------------DDLPTFDLSVFFYPAAAFIDRALS----
|....               |  .  .. .| |. ... .||                               . | ...   ...  .||.....    
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

-DDHSKILVHCVMGRSRSATLVLAYLM--------IHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLV
  .....||||..| .||.|...|.||        ... .....|.... . | .. .. .....|.|.  .|.
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 76-204 4.9e-18 61.1 In-house 121-292 (297) alignment 
Range on Protein: 76-204
Range on HMM: 121-292/297.0
LQKAGFTHVLNAAHGR---------WNVDTGpdYYRDMDI----------------------------QYHGVEADDLPTFDLSVFFYPAAAFIDRALSD
... |.|....              |  ..|  .| |. .                            ... .   |  . ...  .. .  ....||. 
vweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--DHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQQR
  .. ..||||..| .|..|...||||      ...... .|.... . | .. .. .....|... ..|....
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_STYXL1_pd Subfamily STYXL1 57-202 6.2e-18 58.5 In-house 13-155 (157) alignment 
Range on Protein: 57-202
Range on HMM: 13-155/157.0
EVWP-KLYIGDEATALDRYRLQKAGFThvlnaAHGRWNVDTGPDYYRDMD-IQYHGVEADDLPTFDLSVFFYPAAAFIDRALSdDHSKILVHCVMGRSRS
|| | |||.|..  | ..   .          ||     |... .  . |  .   .. .| .  ||  ..  |  ||..    . . .||    | |||
evlPgklylGnykqaqnpaikkdlkvk.....ahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrs

ATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQLVQ
|....|||| .|..|| .| ... | .  | |||.|..||.| .|||..
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
subfamily_STYX_pd Subfamily STYX 53-199 6.9e-18 58.3 In-house 10-156 (166) alignment 
Range on Protein: 53-199
Range on HMM: 10-156/166.0
THVNEVWPKLYIGDEATALDR--YRLQKAGFTHVLNAAHGRWNVDTGPDYYRdmDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDdHSKILVHCVMG
 ...|. | |..|  ..|.      |.| | ||..            |..    ...|  ..  | .. ..  ..    .||| .|.    |.|||   |
remqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpd..rfrylvldvadntveniirylptvkefiddslqk.ggkvlvhgnag

RSRSATLVLAYLMIHKDMTLVDAIQQVAKNR-CVLPNRGFLKQLRELDKQ
 ||||.||.||.|    .   .| . | ..| |. || || .||.| .  
isrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0051429 (Phosphotyrosine protein) phosphatases II 57-200 3.3e-17 58.5 In-house 18-224 (272) alignment 
Range on Protein: 57-200
Range on HMM: 18-224/272.0
EVWP-KLYIGDEA---TALDRYRLQKAGFTHVLNAAHGRWNVDTGPDYYRdMDIQYHGVEADDLPTFDLSVFF---------------------------
.|.| .|| ..     || |  ||.. | .....  .       . |.|   .|.|. .   |  ... ....                           
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------YPAAAFIDRALSddHSKILVHCVMGRSRSATLVLAYLMIhKDMT--------------LVDAIQQVAKNR-CVLPNRGF
                      .  ....  |.  . ..||||  |..|..|.|...|..  ...              | .|.... . | .. .. ..
gearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

LKQLRELDKQL
...|.|  ..|
ylflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 93-201 1.3e-16 56.2 In-house 144-276 (317) alignment 
Range on Protein: 93-201
Range on HMM: 144-276/317.0
NVDTGPDYYrDMDIQYHGVEADDL----------------PTFDLSVFFYPAAAFIDRALSD---DHSKILVHCVMGRSRSATLVLAYLM-----IHKDM
 | .   .. . .|... .|  ||                | ...   . .  .|.... .    .....||||..| .|..|...||||      ....
tvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

TLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLV
.. .|.... . |. . .. .....| ..  ...
dveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 97-196 7e-16 54.0 In-house 169-272 (278) alignment 
Range on Protein: 97-196
Range on HMM: 169-272/278.0
GPDYYRDMDIQYHGVEADDLPTfDLSVFFYPAAAFIDRALsDDHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNR-CVLPNRGFL
 . ..  . ..|.|.  ...|. .|| ..    |....   |.....||||. | .|..|....||.      .. ..| .|.... . | . ...  ..
dgesrtvthyhylgwpdhgvpe.slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

KQLREL
..|.|.
rflyea
subfamily_PTPMT1_pd Subfamily PTPMT1 127-184 8.2e-13 43.1 In-house 95-151 (171) alignment 
Range on Protein: 127-184
Range on HMM: 95-151/171.0
PAAAFIDRALSDDHsKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVL
 .  ||..  |. . .. |||  ||.|||||| .||| .. ... .|.. ..| |  .
kgvefiekvaskgk.rvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii
subfamily_MSG5_pd Subfamily MSG5 135-201 9.5e-12 38.3 In-house 94-161 (165) alignment 
Range on Protein: 135-201
Range on HMM: 94-161/165.0
ALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQV-AKNRCVLPNRGFLKQLRELDKQLV
|    . ||||||  | ||||.|..||.| . ...| || ... ..   . |. |.. || | .  | 
aatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevals
0047943 (Phosphotyrosine protein) phosphatases II 104-183 1.4e-11 39.9 In-house 169-253 (273) alignment 
Range on Protein: 104-183
Range on HMM: 169-253/273.0
MDIQYHGVEADDLPTfdLSVFFYPAAAFIDRALSD--DHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNRCV
. ..|.|   .. |.      .     ....||.   ......|||. | .|..|.....|.      .. ... .|.... . |. 
thfhytgwpdhgvpp..slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg
0051299 (Phosphotyrosine protein) phosphatases II 106-182 3.7e-11 38.5 In-house 185-266 (288) alignment 
Range on Protein: 106-182
Range on HMM: 185-266/288.0
IQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNRC
...|     |  . |    .     ....||..... ..|||  | .|..|.....|.      .. ... .|.... . |.
thfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp
0046845 (Phosphotyrosine protein) phosphatases II 102-182 1.1e-10 36.8 In-house 166-254 (284) alignment 
Range on Protein: 102-182
Range on HMM: 166-254/284.0
RDMDIQYHGVEADDLPT--FDLSVFFYPAAAFIDRalSDDHSKILVHCVMGRSRSATLVLAYLMIHK--------DMTLVDAIQQVAKNRC
. . ..|..   .. |.   ||  |.  .  ....  ......|.|||  | .|..|.....|...          ... .|.... . |.
tvthfhytswpdhgvppspedlleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
0050432 (Phosphotyrosine protein) phosphatases II 122-182 7.6e-10 34.1 In-house 216-279 (308) alignment 
Range on Protein: 122-182
Range on HMM: 216-279/308.0
SVFFYPAAAFIDRALsdDHSKILVHCVMGRSRSATLVLAYLM-----IHKDMTLVDAIQQVAKNRC
   .     .... |  ....|.|||  | .|..|.....|.      .. ... .|.... . |.
peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
0048567 (Phosphotyrosine protein) phosphatases II 100-179 2.8e-09 31.5 In-house 33-116 (157) alignment 
Range on Protein: 100-179
Range on HMM: 33-116/157.0
YYRDMDIQYHGVEADDLP-TFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGR---SRSATLVLAYLMIHKDMTLVDAIQQVAK
.  | ...|.   .|. | . .. . |.  .  . . |.  . .| ||| .|.   .|.|||. .||..| ..|  .||. .. 
FsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplri
subfamily_PTPDC1_pd Subfamily PTPDC1 131-203 1.1e-08 29.7 In-house 107-178 (182) alignment 
Range on Protein: 131-203
Range on HMM: 107-178/182.0
FIDRALSDDhsKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRC-VLPNRGFLKQLRELDKQLVQQ
 .. ||...  |. |||  |. |   |. .||. .|..|  .||. | ..|   .  |. .. ..| .. |...
vvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflipl
PTPc_DSPc_SM00012 108-182 3.8e-07 25.6 In-house 7-71 (105) alignment 
Range on Protein: 108-182
Range on HMM: 7-71/105.0
YHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMT-LvdaiqqvaknrC
|.|     .|.   |.. . .|    .  |.... ..|||  | .|..|.|........ ..              
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket...........k
subfamily_PTEN_pd Subfamily PTEN 127-181 8.8e-07 24.1 In-house 100-156 (184) alignment 
Range on Protein: 127-181
Range on HMM: 100-156/184.0
PAAAFIDRALSDDHSK-ILVHCVMGRSRSATLVLAYLMIHKDMTLV-DAIQQVAKNR
..   |.. |. |... . ||| .|. |. .|. |||. .. ..   .|..  |..|
eivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_RNGTT_pd Subfamily RNGTT 139-181 1.3e-06 22.2 In-house 112-154 (189) alignment 
Range on Protein: 139-181
Range on HMM: 112-154/189.0
DHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR
 .. | |||  |  |.  |. .||. ..|. . .|... ||.|
peevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR
subfamily_DSP23_pd Subfamily DSP23 141-181 1.4e-06 23.1 In-house 85-125 (148) alignment 
Range on Protein: 141-181
Range on HMM: 85-125/148.0
SKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNR
  . |||..|| |. |..  ||. .....  .|| .| . |
eavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
subfamily_DSP11_pd Subfamily DSP11 124-197 6.1e-06 20.2 In-house 101-174 (178) alignment 
Range on Protein: 124-197
Range on HMM: 101-174/178.0
FFYPAAAFIDRAlSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAIQQVAKNRCVL-PNRGFLKQLRELD
|      |...   |. . | |||  |  |.  |.  ||. ....   |||..  . |        .||.|..| 
fkeavkeflekn.kdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkle
subfamily_Laforin_pd Subfamily Laforin 99-174 9.8e-06 18.6 In-house 70-144 (183) alignment 
Range on Protein: 99-174
Range on HMM: 70-144/183.0
DYYRDMDIQYHGVEADDLPTfDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLAYLMIHKDMTLVDAI
  |..  . |  .  .|| | .  |   | | ..  || ..  .. |||  |  ||...|  .|.   . .|    
klykeeglayiwlptedlst.esrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvq