Gene DUSP26 in Homo sapiens

Synonym: DUSP24, LDP-4, MKP8, NATA1, SKRP3, DUSP26

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP026_AA protein Get Run
HsapP026_AA_59-208 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP3_pd Subfamily DSP3 57-207 2.2e-69 226.2 In-house 6-159 (162) alignment 
Range on Protein: 57-207
Range on HMM: 6-159/162.0
TACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGT---PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCA
. ....|||.|.||.||...|.....|..|||||||||...|.. .   .| |..|.|.|||.|..|.|.||.| .|.|||.||..||||. ||.||||.
llskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcv

VGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQ
|||||||||||||||.....||||||..|...| |.||.|||.|| .||..|..
vGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkr
0044763 (Phosphotyrosine protein) phosphatases II 44-206 4.8e-48 158.4 In-house 5-171 (178) alignment 
Range on Protein: 44-206
Range on HMM: 5-171/178.0
NVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRG----TPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHR
... |. | ..  . ...|.|..||||||.. .|.... |..|||||..| ..   .|     |...|. ||.|| .  .|....|.. ||. . .||..
trvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

ALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLR
||...||..||||  ||.||.|||.||||....|.| |||. |. .| |.||.|.||||. ...||.
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrll
subfamily_DSP1_pd Subfamily DSP1 64-205 4.5e-37 121.6 In-house 20-156 (163) alignment 
Range on Protein: 64-205
Range on HMM: 20-156/163.0
EVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGlGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLV
.. . |||| .  | |.. |..||||..||.|..    .....|    .|  .. .|||  |.| .|... .||... .. .||.|.||..|.|||.||.
kildfLylGsetvasnleiLkslgitailnvske....ldnvfed.lfeYkklkleDspkadislvfeeviefidevkkk.nGkvlihCqaGisRsstlc

LAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRL
|||||  ....| || . ||..| || || || .|||  ...|
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0048076 (Phosphotyrosine protein) phosphatases II 62-205 6.3e-37 121.8 In-house 4-142 (145) alignment 
Range on Protein: 62-205
Range on HMM: 4-142/145.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNAshsrwRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSAT
..|..||||||.. .|.....|..||||.|||        ..| .| |||.|| .   | ...|.. ..... .||..||... |..||||  ||.|..|
pseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRRL
||.|||||.....| ||...|. .| |..|| |.||.|. ....|
lvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 62-204 8.5e-37 121.4 In-house 4-143 (144) alignment 
Range on Protein: 62-204
Range on HMM: 4-143/144.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSAT
 .|..||||||.. .|..  .|..||||.|.| ...     || .|  ||.|| .  .| ...|.. ..... .||..||. .||..||||  ||.|..|
pseilpglylgslptaldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgt

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
||.||||....|.| ||.. |. .| |..||.|.||.|| ....
lvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP14_pd Subfamily DSP14 61-207 4.4e-36 118.2 In-house 6-146 (157) alignment 
Range on Protein: 61-207
Range on HMM: 6-146/157.0
HADEVWPGLYLGdQDMANNRRELRRLGITHVLNASHsrwrGTPEaYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRaLSQPGGKILVHCAVGVSRSA
.  .. | |.|.    |.....|.. .||...|..      .|.  .  .|... | ..|.|. ... ||...|| |.  ... |||.||||. ||||||
alsqitpsLfls.gvaalskellkkkkitliinvtv....elpn.tklkdiervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaGvSRSA

TLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLRQ
.|.||||| |..|.| || | ||..| || || || .|| .....|..
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
0041856 (Phosphotyrosine protein) phosphatases II 61-206 5e-36 119.4 In-house 18-173 (182) alignment 
Range on Protein: 61-206
Range on HMM: 18-173/182.0
HADEVWPGLYLGDQDM--------------ANNRRELRRLGITHVLNAShsRWRGTPEAYEGLGIRYLGVEAHDSPAFDmsihFQTAADFIHRALSqPGG
. |.....||||..                |.. | |..||||...|..    .  || .| |||.|| .   | ...|    .... |||...|. .||
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.egg

KILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRG---IIPNRGFLRQLLALDRRLR
..||||  ||.|..|||.||||......| ||.| |. .|    |.|| .|..||..|...|.
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
PTPc_motif_SM00404 64-202 2.1e-35 116.7 In-house 4-138 (140) alignment 
Range on Protein: 64-202
Range on HMM: 4-138/140.0
EVWPGLYLGDQDMANNRRELRRLGITHVLNASH-SRWRgtpeaYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATL
.. |.|||| .. |.|.. |  ||||||.|..   ...     .|  |...| .. .|.   ..| ... ..|||..|  . |||.||||..||||||||
rilphlylgskskaqnpallkklgithvinvteevslt.....kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSatl

VLAYLMLYHHLTLVEAIKKVKDHRGI-IPNRGFLRQLLALD
..|||| |..|.| ||.. ||. | |  || .|.|||. . 
iiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0043147 (Phosphotyrosine protein) phosphatases II 61-205 2.9e-35 116.9 In-house 18-160 (172) alignment 
Range on Protein: 61-205
Range on HMM: 18-160/172.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNAShsRWRGTPEAYEGLGIRYLGVEAHDSPAFdMSIHFQTAADFIHR-ALSQPGGKILVHCAVGVSRS
. |.......... ..| ..| |..|||||..|.   ..  .|| .| |||.|| .   | ... .. ... . .||.. .. .|||..||||  ||.|.
ipdrfiatqgplrntladfwrmlkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRt

ATLVLAYLMLyHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRL
.|||.||||| ..|.| ||.. |...|. ...| ...|.|. ....|
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP19_pd Subfamily DSP19 62-204 7.6e-35 114.5 In-house 12-149 (152) alignment 
Range on Protein: 62-204
Range on HMM: 12-149/152.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHsrwrGTPEAYEgLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSAT
. || | |||| || |.....|.. .|||.|| .     |.|...    . || .|  | |  |.. ....| |||. |.|.  | .||||  ||||||.
vgeveprlylgsqdvaadkeilkekkitHilnvat....gvpnvfp.kdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSRsas

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
.|.||||  ..|.| ||...|...|  | || ||..|| ... .
vviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP10_pd Subfamily DSP10 61-207 5.7e-34 111.3 In-house 13-155 (159) alignment 
Range on Protein: 61-207
Range on HMM: 13-155/159.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSA
 | .| | |.||..  |..   |.||.||.|||   |    .|  .|. ...|  ....|.   ... .|. | .||. |  . | ..||||  |.||||
pasqvlpfLflGsekdaadldaldrlnitavlnvtts....vPnefeeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaGisrsa

TLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLRQ
|.|.|||| . .|.| .| | ||. | || || .|. ||| ....|..
tvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP12_pd Subfamily DSP12 63-198 9.4e-34 111.0 In-house 3-136 (155) alignment 
Range on Protein: 63-198
Range on HMM: 3-136/155.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWrgtP-EAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALsQPGGKILVHCAVGVSRSAT
... ||||||.  .... . |. |.|||||   . .    | .  .   .... ... |.|  |.  |...| |||. || . .|..||||..|||||.|
srilpglylggleavqeeellkelkithvlsvikeel...pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvt

LVLAYLMLYHHLTLVEAIKKVKDH-RGIIPNRGFLRQL
.|.|||| ...| | .|.|.||.  . | || |||.||
iviAYlmkkeklslekAlklvkekkpeiepNegFleQL
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 63-204 1e-33 109.9 In-house 8-146 (148) alignment 
Range on Protein: 63-204
Range on HMM: 8-146/148.0
DEVWPG-LYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
 |.... |.||.. .| .   |. ||.|.. ||...|    . |..  ||.|| |. .| | .|.|  |.....|...| .. |...|||. .|||||. 
seikdafLFlGskksaadlealkalgvtrivnatker....dnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakde.GrrvLvhlqmGvsrssa

LVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRR
|.|..|. ... .| ||.  ||. | .. || |||.||  |...
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0045098 (Phosphotyrosine protein) phosphatases II 52-207 1.4e-33 111.9 In-house 12-273 (278) alignment 
Range on Protein: 52-207
Range on HMM: 12-273/278.0
LYTGKTACNHADEVWPGLYLGDQD-----------------------------------------MANNRRELRRLGITHVLNASHSRWR----------
 .  . .... .|..|.||||..|                                         .|.. | |. ||||..... .   .          
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

-------------------------------------GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQ-------------PGGKILV
                                      . | ..   . ||... |..| .... .|. . .||..||..             .||..||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCAVGVSRSATLVLAYLMLYH---HLTLVEAIKKVKDHRG--IIPNRGFLRQLLALDRRLRQ
||  ||.|..|||.|||||..   ...| ||.|... .|.  ...| ...|.|  . ..|..
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
PTEN_1 59-208 2.3e-33 110.7 In-house 41-194 (196) alignment 
Range on Protein: 59-208
Range on HMM: 41-194/196.0
CNhadEVWPGLYLGDQDMA-NNRRELRRLGITHVLNASHSRWR----GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQP-GGKILVHC
.    |...|||.| .. . .....|   |||.|.| |. ..     ...| ..  |..|| ..  | .| ..| .|  ...||. .||.| |...||||
lq...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

AVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDRRLRQG
. |..||.|.| |||| .. ||  ||.. |...|  . || .....||   ..|...
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0036282 (Phosphotyrosine protein) phosphatases II 63-204 1.3e-32 108.3 In-house 13-168 (174) alignment 
Range on Protein: 63-204
Range on HMM: 13-168/174.0
DEVWPGLYLGDQDMAnNRRELRRLGITHVLNASHSRWRG----------TPEAYEGLGIRYLGVEAHDSPAFDMSIhFQTAADFIHRALSQ-PGGKILVH
 ...|.|..|.  .| . ..|..||||.|..  ... .|          ..| .| |||.|| .   |  ..|.|| .... .|...|||. |||..|||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CAVGVSRSATLVLAYLMLYHHL-TLVEAIKKVKDHR----GIIPNRGFLRQLLALDRR
|  ||.|..|||.|||||...| .||.|.. |.  |    |.... ...|.|  ... 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
DSPc Dual specificity phosphatase, catalytic domain 69-203 2.3e-32 106.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 69-203
Range on HMM: 1-132/133.0
LYLGDQDMANnRRELRRLGITHVLNASHSR-WRgtpEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYL
|||| .  |.  . |  ||||.|.|....  ..    |..   |.||..  .|.   ..| ... | .||..|  | |.|.||||. |.||||||..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
| ...|.| ||.. ||. |. | || |||||||...|
mktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 69-203 2.3e-32 106.7 In-house 1-132 (133) alignment 
Range on Protein: 69-203
Range on HMM: 1-132/133.0
LYLGDQDMANnRRELRRLGITHVLNASHSR-WRgtpEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYL
|||| .  |.  . |  ||||.|.|....  ..    |..   |.||..  .|.   ..| ... | .||..|  | |.|.||||. |.||||||..|||
lylgskstas.lalleklgitlvinvtkevpnn...naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYl

MLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
| ...|.| ||.. ||. |. | || |||||||...|
mktknlslneAyefvkerrskispnagflrqLleyer
0046846 (Phosphotyrosine protein) phosphatases II 60-205 6.7e-32 106.0 In-house 10-172 (176) alignment 
Range on Protein: 60-205
Range on HMM: 10-172/176.0
NHADEVWPGLYLGDQD----------MANNRRELRRLGITHVLNASHSR-------WRGTPEaYEGLGIRYLGVEAHDSPAFDMsIHFQTAADFIHRALS
.. |.....|.||.            .|.. ..|..||||.|.|    .       ..  || .|.|||.|| .   |  . |.  ..... .||..||.
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealk

QPgGKILVHCAVGVSRSATLVLAYLMLY-HHLTLVEAIKKVKDHR--GIIPNRGFLRQLLALDRRL
.  |..||||  |..|..|||.|||. . ..|.. ||...|...|  |........|.|    ..|
eg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0049260 (Phosphotyrosine protein) phosphatases II 63-203 7.5e-32 105.5 In-house 9-147 (152) alignment 
Range on Protein: 63-203
Range on HMM: 9-147/152.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLgiRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATL
 |.......|....|.. | |..||||....     ..| .  ...   .|| .   |... |.|.... . .||.... ..||..||||  ||.|..||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VLAYLMLyHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDR
|.||||| ....| ||.. |. .|  ..|| |.||.|.  ..
vaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0049772 (Phosphotyrosine protein) phosphatases II 69-205 5.5e-31 103.8 In-house 155-273 (314) alignment 
Range on Protein: 69-205
Range on HMM: 155-273/314.0
LylgDQDMANNRRELRrlgithvlnashsrwR--GTPEAYEGLGIRYLGVEAHDsPAFDMSIHFQTAADFIHRAlsQPGGKILVHCAVGVSRSAT-LVLA
    ..  | .  .|.               .    || .|.|||.|| .   | . .. . .|. . .||..|  ..||..||||. |..|..| .|.|
g...neptaadlellk...............eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaa

YLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRL
|||......| ||.. |.  | | ||.||..||. .  .|
ylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
0051082 (Phosphotyrosine protein) phosphatases II 61-201 1.9e-30 100.8 In-house 7-149 (151) alignment 
Range on Protein: 61-201
Range on HMM: 7-149/151.0
HADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWR-GTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRS
..  |..|||.... .| . ..|..|||....|      |   || .. |||..| .  .| |.......|.....|.. .|....|..||||  |..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATLVLAYLMLyHHLTLVEAIKKVKDHRG--IIPNRGFLRQLLAL
.|||..|||| ....| ||.. .. .|.  ..|| .|| ||.||
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP15_pd Subfamily DSP15 63-200 2.7e-30 99.5 In-house 3-134 (151) alignment 
Range on Protein: 63-200
Range on HMM: 3-134/151.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEayeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATL
..| ||||||.   ....  |..  |||.|. . .  .  ..      |.|. ..| |.|  ..| .|. . .|||.. .. ....||||..|||||.||
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd......ieYkciaasDtpsaklskffkesvefihkcRlk.eenvlvhClaGvsRsvtl

VLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
| ||||   .|   .|.. .| .| .  || || |||  
vvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlke
subfamily_DSP6_pd Subfamily DSP6 63-206 5.5e-30 98.0 In-house 15-155 (158) alignment 
Range on Protein: 63-206
Range on HMM: 15-155/158.0
DEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLG-IRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
 |. | |||| .. |.|.  |..|.| .|||  . .    |...|  | ..|| . ..|    ... .|  | .||  | |.   |.||||  |.||| |
veilpllylGsakdasnlevlkklkikyvlnvtsnl....pnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrsvt

LVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRLR
..||||| ...|.| .| . ||...  | ||  |. |||  .|.||
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_LRR-DSP_pd Subfamily LRR-DSP 62-205 2.5e-28 92.9 In-house 120-258 (263) alignment 
Range on Protein: 62-205
Range on HMM: 120-258/263.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYeglgiRYLGV-EAHDSPAFDMSIHFQTAADFIHRALSQpgGKILVHCAVGVSRSA
 ||. ..|.|| .| |||.  |. ||.||.| |        |. .     .|| . ...| . .|.| ||.    ||.    .  | .||||  |||||.
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklf.....kylsiddiedvdeadisqhfeetnafieeGrkk..GGvlvhcraGvsrss

TLVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRL
|||..||| ...|.. ||.  |. .|  | ||.||. ||.  .. |
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_MKPLT_pd Subfamily MKPLT 69-200 3.4e-28 92.2 In-house 29-155 (164) alignment 
Range on Protein: 69-200
Range on HMM: 29-155/164.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAyeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSATLVLAYLM
||||. . |.|.. |. | |||..| |  .    |..     . || |. .| .   .| ... ||.|.  |.   ||..||||  |.|||..  .|.|.
lylGnakhatnekvlkdlkithivnvsqekkdafpks.....veYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLi

LYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
...  || || . .|. | |. ||||||.||  
kskgwtlkeayeylkerrsivapnrGflkqlak
subfamily_MKPLV_pd Subfamily MKPLV 69-200 3.4e-28 92.2 In-house 29-155 (164) alignment 
Range on Protein: 69-200
Range on HMM: 29-155/164.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAyeglgIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSATLVLAYLM
||||. . |.|.. |. | |||..| |  .    |..     . || |. .| .   .| ... ||.|.  |.   ||..||||  |.|||..  .|.|.
lylGnakhatnekvlkdlkithivnvsqekkdafpks.....veYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLi

LYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
...  || || . .|. | |. ||||||.||  
kskgwtlkeayeylkerrsivapnrGflkqlak
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 68-206 2.4e-27 89.2 In-house 9-153 (154) alignment 
Range on Protein: 68-206
Range on HMM: 9-153/154.0
GLYLGDQDMANNRRELRRLGITHVLNASH---SRWRGT-PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRAL-SQPGGKILVHCAVGVSRSATL
 ||.. .| | |. .|.   |...|| .      .     .  .|. | || .| .| . ||.  ... | .||. |. .   .|.|||.  ||||||.|
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLR
...|||   ...| .|.. .|| | || ||.|||.||   ...|.
lisylmdklkislslalellkdsryiikPnqGflkqleifekell
0037934 (Phosphotyrosine protein) phosphatases II 64-200 1.8e-26 88.6 In-house 41-236 (243) alignment 
Range on Protein: 64-200
Range on HMM: 41-236/243.0
EVWPGLYLGDQ--------DMANNRRELRRLGITHVLNASHSR------------------------------------------WRGTPEAYEGLGIRY
.|.|.|.....        |.|.. | | .||||....  .                                            .  ... ...  . |
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

LGVEAHDSPA--FDMSIHFQTAADFIHRA----LSQPGGKILVHCAVGVSRSATLVLAYLMLYH-HLTLVEAIKKVKDHRG--IIPNRGFLRQLLA
|..  |. |    |.  ... . .||...       .||..||||  ||.|..||..|||||.. ...| ||.|.....|.  ........|.|  
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye
0040439 (Phosphotyrosine protein) phosphatases II 65-202 7.3e-26 86.7 In-house 32-242 (249) alignment 
Range on Protein: 65-202
Range on HMM: 32-242/249.0
VWPGLYLG------------------------DQDMANNRRELRRLGITHVLNASHSRWRGTPEA-----------------------------------
..|||.|.                        .. .....| |..||||.......   .|                                       
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---YEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPN
   |.|  ...|..  .| | .. . .|... |||.....      .||..||||  ||.|..|...||||      .....| ||.|.....| |...|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

RGFLRQLLALD
 ...|.|. . 
peqyrflyeal
subfamily_Slingshot_pd Subfamily Slingshot 60-200 8.4e-26 84.4 In-house 17-152 (169) alignment 
Range on Protein: 60-200
Range on HMM: 17-152/169.0
NHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSrwrgTPEAYEGlGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRS
..| ...  .||| .  | |  ||.. |....|| ..       . ...  ..|| .  .|... |.  ..... .||..| .. | |.|||| .|||||
dsaskifdhvylGsewnasnleelkengveyilnvtke....idnffpe.kfeylnirvydeeetdllkywnetykfiekakkk.gskvlvhckmGvsrs

ATLVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLA
|. |.|| |  ..|.| ||.. ||..| .| ||.|||.|| .
astviayamkeyglsleealeyvkerrsvikPnkgflkqlee
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 69-207 2.7e-25 82.2 In-house 6-143 (145) alignment 
Range on Protein: 69-207
Range on HMM: 6-143/145.0
LYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYeGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLM
|| |    ||.   |. |||. ..| . .    . |.. .  |  | . |.|  ..|.| ||.  .||| .   . |  ..|||  ||||| |. .|.||
lyvgsalhandvptlqelgisrivnmaagslvasqelk.sesieillitaedlesydlsqhfdevtdfidkgkee.gagvfvhcmagvsrsvtvsvaflm

LYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLALDRRLRQ
 |  .|| || ..|. .|   .||  ||..|| |...|..
kycnmtlseaarqvrsnrllaypnvtflknllnlekqlke
0042113 (Phosphotyrosine protein) phosphatases II 62-199 5e-25 83.8 In-house 42-236 (245) alignment 
Range on Protein: 62-199
Range on HMM: 42-236/245.0
AD-----EVWPGLYLGDQDMANNRR----ELRRLGITHVLNASHSRWR-------------------------------------------GTPEAYEGL
|      ...|....... ....       |..||||.... .    .                                           |..|  |..
asyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevi

GIRYLGVEahDSPAFDMSIHFQTAADFIHRALS-QPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLL
 ..||...  | .. |.. ... . .|...||.  ..|..||||  ||.|..|...||||      .. ..| ||.|.....| |.... ...|.| 
hyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
subfamily_DSP8_pd Subfamily DSP8 62-206 2.8e-24 79.5 In-house 15-155 (159) alignment 
Range on Protein: 62-206
Range on HMM: 15-155/159.0
ADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRwrgtPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSAT
  .. . |||| |  . ..  |..|||..|||||.|     |.  |    ..| |  .|.   ...  |... .|| .| |.  |..|||.  | |||||
ptrilknlylGsqkdvlseellsklgisyvlnasnsc....pkleelkeskflrvPvkDkydekllpwfdksvefidkakse.ngrvlvhvlaGisrsat

LVLAYLMLYHHLTLVEAIKKVKDHRGII-PNRGFLRQLLALDRRLR
...||.| . ...| || . ||..|  | ||  || |||  ...|.
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0045450 (Phosphotyrosine protein) phosphatases II 66-201 4.2e-24 81.3 In-house 94-299 (307) alignment 
Range on Protein: 66-201
Range on HMM: 94-299/307.0
WPGLYLGDQDMANNR----------------RELRRLGITHVLNASHSRWRGTP-----------------------EAYEGLGIRYLGVEAHDS-----
.| |.|.|    ...                | |...|.|.... ...  .| .                       . ..  |. .. .| .|.     
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

------------PAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVSRSATLVLAYLMLYHH--------LTLVEAIKKVKDHR-GIIPNRGFL
            | .. . .|... |||.....     ..||..||||  ||.|..|...|||||...        ..| ||.|.....| |...| ...
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

RQLLAL
|.|  .
rflyea
0038934 (Phosphotyrosine protein) phosphatases II 58-201 9.5e-23 76.3 In-house 27-172 (194) alignment 
Range on Protein: 58-201
Range on HMM: 27-172/194.0
ACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHD---SPAFDMSIHFQTAADFIHRAlsQPGGKILVHCAV
.... |.....||  . ..  .  .|.  ....|.. ...     || .|..||.||     |   .| ...  .|  ..|.....  .|||...|||  
lsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCka

GVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLAL
|..|..||| |||. ...... |||. ... | |.|||...|..||  
GlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
0036941 (Phosphotyrosine protein) phosphatases II 63-201 2.9e-22 74.7 In-house 20-272 (297) alignment 
Range on Protein: 63-201
Range on HMM: 20-272/297.0
DEVWPGLYLGDQDMANNRRELR----------------------------------------------------------RLGITHVLNASHSRWR----
.|..| |.||. . |.. . |                                                            ...|.... .    .    
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

---------GTPEAYEGLGIRYLGVEA-----------------------------HDSPAFDMSIHFQTAADFIHRALS-----QPGGKILVHCAVGVS
         | .  |... ...|.||                              .. | ...  ....  |||.....      .||..||||  ||.
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSATLVLAYLM--------LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLAL
||.|...|.||         .. ....||.||....| |.... ...|.|  .
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 64-201 2.4e-21 72.0 In-house 18-220 (272) alignment 
Range on Protein: 64-201
Range on HMM: 18-220/272.0
EVWPG-LYLGDQD---MANNRRELRRLGITHVLNASHSRWRGTPE-AYEGLGIRYLGVEAHDSPAFDMSIHF----------------------------
.|.|| ||....     |.. . |..|||.....  .   ||     ..  ||||| .  .|. |.......                            
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------QTAADFIHRALSqpGGKILVHCAVGVSRSATLVLAYLMLyHHLT--------------LVEAIKKVKDHR-GIIPNRGFL
                    ..  ....  |.  ||..||||. |..|..|.|...|.| . ..              | ||.......| |.... ...
earevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

RQLLAL
..|.  
lflyea
subfamily_STYX_pd Subfamily STYX 61-200 2.1e-20 66.4 In-house 11-152 (166) alignment 
Range on Protein: 61-200
Range on HMM: 11-152/166.0
HADEVWPGLYLGDQDMANN--RRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSR
. .|. |||.||    | .     |.. ||||..    .             .||| ..  |..  ..  .. |  .||  .|.. |||.|||   |.||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk.ggkvlvhgnagisr

SATLVLAYLMLYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLA
||.||.||.|  . |   || . |...|  | || || .||  
saalviayimetyglkyreafayvqerrfcinpnegfvsqlke
0040438 (Phosphotyrosine protein) phosphatases II 80-201 5.1e-20 67.4 In-house 103-271 (317) alignment 
Range on Protein: 80-201
Range on HMM: 103-271/317.0
RRELRRLGITHVLNASHSRWRGT----------------------PEAYEGLGIRYLGVEAHDS----------------PAFDMSIHFQTAADFIHRAL
 | . ..|.|....  ..  .|                        . .|  || .. .|  |.                | ..   ....  ||.... 
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

SQ---PGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG-IIPNRGFLRQLLAL
..   |||..||||  ||.|..|...||||      ...... ||.|... .|. .... ...|.|  .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 80-199 1.2e-19 66.3 In-house 105-270 (278) alignment 
Range on Protein: 80-199
Range on HMM: 105-270/278.0
RRELRRLGITHVLNASHSRWR------------------------------------------GTPEAYEGLGIRYLGVEAHDSPAfDMSIHFQTAADFI
.| .. ||.|....      .                                          |..| ...... |||.  |. |  ..|....   ...
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavr

HRALsQPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLL
..    ..|..||||  ||.|..|....||.      .....| ||.|... .| |....  ..|.| 
eale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
0039614 (Phosphotyrosine protein) phosphatases II 80-203 1.6e-19 66.0 In-house 118-286 (297) alignment 
Range on Protein: 80-203
Range on HMM: 118-286/297.0
RRELRRLGITHVLNASHSR---------WRGTPEAYEGLGIRYLGVEA----------------------------HDSPAFDMSIHFQTAADFIHRALS
 | ....|.|....              |  . . |... ...|.||                              |  . . . ... . .....||.
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

Q--PGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDR
.  .||..||||  ||.|..|...||||      ...... ||.|... .| |.... ...|.|  . .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
subfamily_STYXL1_pd Subfamily STYXL1 64-203 6.7e-18 58.4 In-house 13-151 (157) alignment 
Range on Protein: 64-203
Range on HMM: 13-151/157.0
EVWPG-LYLGDQDMANNRRELRRLGITHVLNASHSRWRgtpeAYEGL--GIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSqPGGKILVHCAVGVSRSA
|| || ||||.   | |..  . | .  ..| |.   .     ..|.    . | .. .|..  |.  ... | .||..     |  .||    |.||||
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk....liagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsa

TLVLAYLMLYHHLTLVEAIKKVKDHR-GIIPNRGFLRQLLALDR
....|||| ....|| .| |..|. .  . |||.|. ||   ..
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
subfamily_MSG5_pd Subfamily MSG5 131-202 1.2e-16 54.3 In-house 86-157 (165) alignment 
Range on Protein: 131-202
Range on HMM: 86-157/165.0
QTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDH-RGIIPNRGFLRQLLALD
 . .  || | |. . ||||||  |.||||.|..||.| |. |.| .| .|.|     | |. |.. ||.  .
srltriihaatsk.rkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
subfamily_PTPMT1_pd Subfamily PTPMT1 100-192 4.6e-15 50.5 In-house 63-154 (171) alignment 
Range on Protein: 100-192
Range on HMM: 63-154/171.0
RGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQpGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNR
  . | .. ||. .| ..  |        . . . .||..  |. | .. |||  | .|||||| .|||. ..|.. ||.| .|. | ||  .
ansteewkklgveqlqlatvDfteapdleklekgvefiekvask.gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirla
0047943 (Phosphotyrosine protein) phosphatases II 101-195 4.1e-14 48.2 In-house 161-261 (273) alignment 
Range on Protein: 101-195
Range on HMM: 161-261/273.0
GTPEAYEGLGIRYLGVEAHDSP-AFDMSIHFQTAADFIHRALSQPgGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHR-GIIPNRG
||.| ..   . |.|   |. |  ... ..|  ... ...|| .. |...|||  ||.|..|.....|.      .. ... ||.|.....| |....  
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

FL
..
qy
0051299 (Phosphotyrosine protein) phosphatases II 99-187 1.9e-13 46.0 In-house 175-266 (288) alignment 
Range on Protein: 99-187
Range on HMM: 175-266/288.0
WRGTPEAYEGLGIRYLGVEAHDSPAfdMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG
..|. | ..   . |..   |. |      .. .   ....||...|| ..|||  ||.|..|.....|.       ..... ||.|... .| 
ldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp
0046845 (Phosphotyrosine protein) phosphatases II 102-187 3.7e-13 44.9 In-house 161-254 (284) alignment 
Range on Protein: 102-187
Range on HMM: 161-254/284.0
TPEAYEGLGIRYLGVEAHDSPA-FDMSIHFQTAADFIHRAlSQPGGKILVHCAVGVSRSATLVLAYLMLYH--------HLTLVEAIKKVKDHRG
| | ..   . |..   |. |. ..  ..|  ... .... . .||.|.|||  ||.|..|.....|.|..        .... ||.|.....| 
tgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
0050432 (Phosphotyrosine protein) phosphatases II 111-187 8.3e-12 40.5 In-house 202-279 (308) alignment 
Range on Protein: 111-187
Range on HMM: 202-279/308.0
IRYLGVEAHDSPA-FDMSIHFQTAADFIHralsqPGGKILVHCAVGVSRSATLVLAYLM-----LYHHLTLVEAIKKVKDHRG
. |.. . |. |  ... ..|  ...  .     |||.|.|||  ||.|..|.....|.       ..... ||.||.. .| 
fhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
0048567 (Phosphotyrosine protein) phosphatases II 123-186 3.8e-10 34.3 In-house 52-118 (157) alignment 
Range on Protein: 123-186
Range on HMM: 52-118/157.0
AFDMSIHFQTAADFIHRALSQPGGKILVHCAVGV---SRSATLVLAYLMLYHHLTLVEAIKKVKDHR
  .. ..| . .. . . |.  |..| |||  |    .|.|||. .||.|....|  |||. ..  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
PTPc_DSPc_SM00012 129-172 1.2e-07 27.2 In-house 21-66 (105) alignment 
Range on Protein: 129-172
Range on HMM: 21-66/105.0
HFQTAADFIHRALSQP--GGKILVHCAVGVSRSATLVLAYLMLYHH
.. .. . ...  ..   .. ..|||  ||.|..|.|.....| ..
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql
subfamily_PTPDC1_pd Subfamily PTPDC1 139-187 2.7e-07 25.2 In-house 110-156 (182) alignment 
Range on Protein: 139-187
Range on HMM: 110-156/182.0
RALSQpgGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRG
 ||..  ||. |||  |  |   |. .||.  ..||  .|||.|...| 
falqe..gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_DSP23_pd Subfamily DSP23 81-186 3.1e-07 25.2 In-house 25-125 (148) alignment 
Range on Protein: 81-186
Range on HMM: 25-125/148.0
RELRRLGITHVLNAShSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADfihRAlSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIK
| |  ||. ...  .  . |   ||  .| .  |... .  || .   .|    .    |  . .  . |||. |  |. |..  ||.  ..|.  ||| 
rylldlgvrylvslt.eegrphveatpnltlvrlriddyhppaleqvvefvrvve...ea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaia

KVKDHR
.|.  |
evrrlr
subfamily_DSP11_pd Subfamily DSP11 102-192 9e-07 22.9 In-house 71-163 (178) alignment 
Range on Protein: 102-192
Range on HMM: 71-163/178.0
TPEAYEGLGIRYLGV--EAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNR
 .....  |..|| .    |. |  ..  .|. | .       . .  | |||. || |.  |.  ||.  . .   .||.. .. ||   .|
kkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler
subfamily_CDC14_pd Subfamily CDC14 125-181 1.2e-06 22.6 In-house 243-299 (328) alignment 
Range on Protein: 125-181
Range on HMM: 243-299/328.0
DMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKK
| |.  ..      ... .  |.| |||  |. |  ||. .|||  ...|  |||  
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiaw
subfamily_RNGTT_pd Subfamily RNGTT 109-186 1.8e-06 21.8 In-house 76-154 (189) alignment 
Range on Protein: 109-186
Range on HMM: 76-154/189.0
LGIRYLGV--EAH-DSPAFDMSIHFQTAADFIHRalSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHR
 ||.|  .  ... ..|  .   .|..  .  ..   .|   | |||  |  |.  |. .||.  ..  . .|..  .  |
egikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR
subfamily_Laforin_pd Subfamily Laforin 110-177 3.5e-06 20.0 In-house 76-142 (183) alignment 
Range on Protein: 110-177
Range on HMM: 76-142/183.0
GIRYLGVEAHDSPAfDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVE
|. |. .  .|  . .  ..    | ..  || . | .. |||  || ||...|  .|.   . .|  
glayiwlptedlst.esrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 129-161 4.5e-06 20.6 In-house 210-242 (301) alignment 
Range on Protein: 129-161
Range on HMM: 210-242/301.0
HFQTAADFIHRALSQPGGKILVHCAVGVSRSAT
  |   | |||  .  ||...|||  .|||| .
vLqviddvihrqqkigggpvvVHCSdtVsrsGv
Y_phosphatase Protein-tyrosine phosphatase 132-186 6.2e-06 21.2 Pfam-A 154-216 (235) alignment 
Range on Protein: 132-186
Range on HMM: 154-216/235.0
TAADFIHRALSQP---GGKILVHCAVGVSRSATLVLAYLMLYHHLT-----LVEAIKKVKDHR
   |.|..  ..     |...|||  ||.|..|.|.. ..| .  .     .....|... .|
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 132-186 6.2e-06 21.2 In-house 154-216 (235) alignment 
Range on Protein: 132-186
Range on HMM: 154-216/235.0
TAADFIHRALSQP---GGKILVHCAVGVSRSATLVLAYLMLYHHLT-----LVEAIKKVKDHR
   |.|..  ..     |...|||  ||.|..|.|.. ..| .  .     .....|... .|
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 114-174 7.8e-06 16.2 Pfam-A 344-405 (451) alignment 
Range on Protein: 114-174
Range on HMM: 344-405/451.0
LGVEAHDSPAFDMSIHFQTAADFIHRALSQ-PGGKILVHCAVGVSRSATLVLAYLMLYHHLT
|..|.    . ... .......||.. ||. .  ||||.|  |   |...||| | ||....
lklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdee
NMT Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain 125-165 8.2e-06 11.9 Pfam-A 53-93 (162) alignment 
Range on Protein: 125-165
Range on HMM: 53-93/162.0
DMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLA
|    |. ...|.. || .|| |   |. | |...  ||  
damfrfdyskeflkwalkapGfkkdwhvGvrvkktkklvaf