Gene DUSP7 in Homo sapiens

Synonym: MKPX, PYST2, DUSP7

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP030_AA protein Get Run
HsapP030_AA_242-386 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP6_pd Subfamily DSP6 239-388 2e-85 278.2 In-house 8-157 (158) alignment 
Range on Protein: 239-388
Range on HMM: 8-157/158.0
SSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRS
... .|||.|||.||||.|||..||.|| |..|||.||||.||||.||. ||..|.||||.||.||||..||||||.|||||||||..||||||||||||
kaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrs

VTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLS
||||.||||.|..||||||||.||..|||||||||||||||||||.|.||
vtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
subfamily_DSP10_pd Subfamily DSP10 245-385 2.2e-61 200.4 In-house 14-153 (159) alignment 
Range on Protein: 245-385
Range on HMM: 14-153/159.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHgGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVA
 .|.||.|.|| .||...||.| ...|...||||...|| ||.  ...||.||.||  .|||.| | ||. ||.|||.|   ||||| ||||||.||..|
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
|||...||||||||.||| |.. ||||.|||||||.||..|
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_DSP1_pd Subfamily DSP1 242-387 9.7e-49 159.6 In-house 13-158 (163) alignment 
Range on Protein: 242-387
Range on HMM: 13-158/163.0
PAF-PVQ-ILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSV
... ||. ||..|||| .....||..| . ||  ||||. .|.|.||.   |.||.....|. ....|. | |.| ||||...|.  ||.|| |||||| 
klydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

TVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGL
|. .||||.. ..||..|.||||...| ||||..|..|||..|..|.|
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
PTPc_motif_SM00404 245-383 1e-47 156.5 In-house 2-139 (140) alignment 
Range on Protein: 245-383
Range on HMM: 2-139/140.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAfEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVA
| .|||.|||| .....|...| |.||....||| . ..  ..  .|...|||..|. ...||........||..|..|.. ||||| ||.|||.|...|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||....|||..||.|||.....||||.||. ||...|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP8_pd Subfamily DSP8 244-386 1.3e-47 155.3 In-house 14-155 (159) alignment 
Range on Protein: 244-386
Range on HMM: 14-155/159.0
FPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAfEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
 | .||..||||. ||. . ..| |.|| |.||.  . |.  |   |  . ..|. |. . .|...|.....||| |.|... ||||.||||||| || .
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLG
||.|.....||..|| ||| |.  ||||.||.||||..|..| 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
DSPc Dual specificity phosphatase, catalytic domain 252-383 1.5e-44 146.1 Pfam-A 1-132 (133) alignment 
Range on Protein: 252-383
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLGKYGIKYILNVTPNLPN-AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKM
|||| ..... |..| |.||....||| . ||  . . .|..| .||. |......|....||..||..|..|.. ||||| |||||| |...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||||.||.|||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 252-383 1.5e-44 146.1 In-house 1-132 (133) alignment 
Range on Protein: 252-383
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLGKYGIKYILNVTPNLPN-AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKM
|||| ..... |..| |.||....||| . ||  . . .|..| .||. |......|....||..||..|..|.. ||||| |||||| |...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||||.||.|||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
0044763 (Phosphotyrosine protein) phosphatases II 238-386 9.7e-43 141.2 In-house 16-171 (178) alignment 
Range on Protein: 238-386
Range on HMM: 16-171/178.0
PSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGE-------FTYKQIPISDHWSQNLSQFFPEAISFIDEAR-SKKCGVLV
..|..  ...|||.||||.. .. .|. | ..||..|.|.|..|.. |..  .       ..|..|||.||  ..|...|.|.. ||.||. .|.. |||
ersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlV

HCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSnISPNFNFMGQLLDFERTLG
|| ||..|| |. .|||| |..|||..|...|..... |.||.... ||..||. | 
HCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP19_pd Subfamily DSP19 247-384 5.6e-39 127.9 In-house 14-149 (152) alignment 
Range on Protein: 247-384
Range on HMM: 14-149/152.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYL
.. |.||||     .. . | . .| .||||. ..||.| .  .|||..|.| |.  ..|.....||. ||.|||||.  ||||| ||.|||..| .|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|.| .|||..|.. |. .. .|.||  |. || ..| .
mkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP12_pd Subfamily DSP12 247-385 1.5e-38 126.6 In-house 4-143 (155) alignment 
Range on Protein: 247-385
Range on HMM: 4-143/155.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN-LPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAY
.||| |||| ... .. . | ...|. .| |. . ||.  .. |. ..|.|.| |. .... ....||..||.||....  ||||| ||.|||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||.| .|||..|...||.||..|.|| .|. ||  ||.  
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0048179 (Phosphotyrosine protein) phosphatases II 243-384 1.6e-38 127.0 In-house 2-143 (144) alignment 
Range on Protein: 243-384
Range on HMM: 2-143/144.0
AFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVT
 .|..|||.||||.  .. .|. | |.||....|.|.. ...|.    ..| ..|. ||   .|.....|.. ||.||..... ||||| ||..|. |. 
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

VAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
.|||| |..|||..|...|... ... ||.... .||..|. 
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 242-384 9.9e-38 124.4 In-house 1-141 (145) alignment 
Range on Protein: 242-384
Range on HMM: 1-141/145.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGefTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
| .| .|||.||||.  .  .|. | ..||...||.|..|.. ...|   .| ..|. ||  ..|.....|.. ||.||..... ||||| ||..|. |.
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
 .|||| ....|| .|...|... ... ||.... .|..||. 
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_DSP15_pd Subfamily DSP15 247-384 2.8e-37 122.1 In-house 4-138 (151) alignment 
Range on Protein: 247-384
Range on HMM: 4-138/151.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPnlpNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYL
..|| ||||  .|| . . |..  |  ||.|     || ..  ...|| |..||  |..||.|| |...|| ..|.|. .||||||||.|||||..||||
kvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|  ..|. .|| ...| ..|   ||| |  || ..|.|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_Slingshot_pd Subfamily Slingshot 242-385 2.3e-36 118.8 In-house 16-157 (169) alignment 
Range on Protein: 242-385
Range on HMM: 16-157/169.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEhgGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
 . . .|  ..|||   ...||. | . |..|||||| .. | |.  ..|.|..| . |. ...| ... |. .||..|..|.  |||||  |.||| ..
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
 .|| |.. .|||..|...||...| | || .|. ||  .|  |
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
0043147 (Phosphotyrosine protein) phosphatases II 244-385 2.5e-36 120.4 In-house 18-160 (172) alignment 
Range on Protein: 244-385
Range on HMM: 18-160/172.0
FPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN-LPNAFEHGGEFTYKQIPISDHWSQnLSQFFPEAISFIDE--ARSKKCGVLVHCLAGISRSVT
 | ..........  .. ... | ..||..|.|.|.  ..  ...   ..|  .|. ||. . |.....|...||||  |.|... ||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VTVAYLMQkMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
. .||||. ..||| .|...|..|......|.... .|..||..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP14_pd Subfamily DSP14 246-385 1.8e-34 113.0 In-house 8-144 (157) alignment 
Range on Protein: 246-385
Range on HMM: 8-144/157.0
VQILPYLYLGcAKDSTNLDVLGKYGIKYILNVTPNLPNafEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAY
.|| |.|.|. .  ... ..| |..|  |.|||..|||  ..  .. . ..|..|. ...|...| |..  |.|.. |.  .|||| ||.||| ....||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||.  .|||..||  || ... |.||  |  || |.|. |
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0041856 (Phosphotyrosine protein) phosphatases II 240-385 2.9e-34 113.6 In-house 14-172 (182) alignment 
Range on Protein: 240-385
Range on HMM: 14-172/182.0
SQPAFPVQILPYLYLGCAKD--------------STNLDVLGKYGIKYILNVTpnlpN------AFEHGGeFTYKQIPISDHWSQNlsqfFPEAISFIDE
 .. .. .|...||||. ..                .|. | ..||..|.|.|    .       .|. | ..|...|. ||   .    ..|...||.|
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpellerlg.iqylylpwpDhgvpd....ldelldfiee

ARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS--NISPNFNFMGQLLDFERTL
...... ||||| ||..|. |. .|||| |...|| .|...|.....   |.||..|. ||. .|. |
vleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
PTEN_1 237-385 1.1e-33 111.7 In-house 34-191 (196) alignment 
Range on Protein: 237-385
Range on HMM: 34-191/196.0
VPSSQPAFPvQILPYLYLGCAKDS-TNLDVLGKYGIKYILNVTPNLPN-------AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKC--G
...|.| .  .| . ||.| .||   .|| |.. ||  ..|...  ..        ..  . ..|...|| ||. ..||..| .. |||. ..|...   
kapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnv

VLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||||| ||..||.||  ||||.|..|. ..| ..|..| ....||  .. .|| ... |
VlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
subfamily_LRR-DSP_pd Subfamily LRR-DSP 242-385 3.6e-33 108.8 In-house 117-258 (263) alignment 
Range on Protein: 242-385
Range on HMM: 117-258/263.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQI-PISDHWSQNLSQFFPEAISFIDEARsKKCGVLVHCLAGISRSVT
 . | .|.. |.||. . ..|  .| . |. .||    ..   | .   | |  |  | |    ..||.| |  .||.| | || |||||| ||.||| |
ssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPk..lfkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsst

VTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
....|||.| .| ...|.|.|..|...| ||  |. ||. .|. |
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0049260 (Phosphotyrosine protein) phosphatases II 245-385 1.2e-32 108.1 In-house 8-149 (152) alignment 
Range on Protein: 245-385
Range on HMM: 8-149/152.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFE-HGGEFTYKQIPISDHWSQNLSQFFPEAISFIDE-ARSKKCGVLVHCLAGISRSVTVT
| ........|.   . ... | ..||..|...|  |..... .   ..|...|. ||. ..|||...... ||.. |..|.. ||||| ||..|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
.||||  ...|| .|...|..|.... ||.... .|..||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0049772 (Phosphotyrosine protein) phosphatases II 282-385 6.2e-31 103.7 In-house 173-273 (314) alignment 
Range on Protein: 282-385
Range on HMM: 173-273/314.0
PNAFEHGGeFTYKQIPISDhWSQNLSQFFPEAISFIDEArSKKCGVLVHCLAGISRSVT-VTVAYLMQKMNLSLNDAYDFVKRKKSnISPNFNFMGQLLD
|. ||. | ..|..||..| .|..|...|.|.. ||.|| .|.  ||||| ||..|. | |..|||| ....||..|...|..| . |.||..|. ||..
pelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleq

FERTL
.|  |
yefil
0036282 (Phosphotyrosine protein) phosphatases II 246-385 3.3e-30 100.5 In-house 13-169 (174) alignment 
Range on Protein: 246-385
Range on HMM: 13-169/174.0
VQILPYLYLGCAKDStNLDVLGKYGIKYILNVTPNLPN-------------AFEHGGEFTYKQIPISDHWSQNLSQfFPEAISFIDEARSK--KCGVLVH
. |.|.|..|..  . ... | ..||........  ..              ...   ..|...|. ||   .||. . |...|..||.|.  .. ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CLAGISRSVTVTVAYLMQKMNL-SLNDAYDFVKRKK---SNISPNFNFMGQLLDFERTL
| ||..|. |. .|||| .. | || ||.|.|....   ... ...... .| .||. |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 244-384 3.8e-30 100.3 In-house 11-171 (176) alignment 
Range on Protein: 244-384
Range on HMM: 11-171/176.0
FPVQILPYLYLGCAK----------DSTNLDVLGKYGIKYILNVTPNL----------PNAfEHGGEFTYKQIPISDHWSQNLsQFFPEAISFIDEARSK
....|...|.||..             ..|. | ..||....|.|             ..  ... ...|...|. ||.  .| . ..|.. ||.||...
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealke

KCGVLVHCLAGISRSVTVTVAYLMQK-MNLSLNDAYDFVKRKKS-NISPNFNFMGQLLDFERT
.  ||||| |||.|. |. .|||... ..||...|...|..... .. ...... .| .||. 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0045098 (Phosphotyrosine protein) phosphatases II 243-385 7.3e-29 96.4 In-house 20-271 (278) alignment 
Range on Protein: 243-385
Range on HMM: 20-271/278.0
AFPVQILPYLYLGCAK-----------------------------------------DSTNLDVLGKYGIKYILNVTPNLPNA-----------------
 .| .|.|.||||...                                          . ... | ..||..|...|. ....                 
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

----------------------------FEHGGEFTYKQI---PISDHWSQNLS--QFFPEAISFIDEARS--------------KKCGVLVHCLAGISR
                            .|.. ... ...   |. || . .|.  ..| |.. ||.||..              ... ||||| ||..|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SVTVTVAYLMQKM---NLSLNDAYDFVKRKKSN-ISPNFNFMGQLLDFERTL
. |. .|||| ..   ...| .|........ . . .|.... .| .|.. |
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_DSP3_pd Subfamily DSP3 248-385 9.2e-29 94.2 In-house 14-157 (162) alignment 
Range on Protein: 248-385
Range on HMM: 14-157/162.0
ILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN------LPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSK-KCGVLVHCLAGISRSVT
. | ||.| .. ... . | | || ..|| .          . | .. |..|  ....|  . .||..| .| .||||| |. .  ||||| .|.||| |
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

VTVAYLMQKMNLSLNDAYDFVKrKKSNISPNFNFMGQLLDFERTL
. .|||| . ...|..|   |. || .| ||  |. || .... |
lvlayLmirrkmtlveairtvr.kkReilPneGFlkqLaeldeel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 244-383 1.7e-28 93.0 In-house 6-145 (148) alignment 
Range on Protein: 244-383
Range on HMM: 6-145/148.0
FPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGeFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVT
|| .| . .|.||  |  ..|..| . |.  | | | . .||... |   | .....|.  ..||..|...|.|...|...   ||||.  |.|||  ..
fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

VAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
...|..  . ||..|...|| |.  . ||  |. || ..|.
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_MKPLT_pd Subfamily MKPLT 245-383 3.1e-28 92.3 In-house 21-158 (164) alignment 
Range on Protein: 245-383
Range on HMM: 21-158/164.0
PVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
|  .|.  |||| ||..||  || .  |..|.||. .  .|| .   . | |. ..|   ..||.|.  |  |. .|      |||||  | ||| .|||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|.|..     |..||...| ..| ..||  |. ||  ||.
afLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 245-383 3.1e-28 92.3 In-house 21-158 (164) alignment 
Range on Protein: 245-383
Range on HMM: 21-158/164.0
PVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
|  .|.  |||| ||..||  || .  |..|.||. .  .|| .   . | |. ..|   ..||.|.  |  |. .|      |||||  | ||| .|||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|.|..     |..||...| ..| ..||  |. ||  ||.
afLikskgwtlkeayeylkerrsivapnrGflkqlakfee
0037934 (Phosphotyrosine protein) phosphatases II 242-384 2.2e-27 91.6 In-house 36-240 (243) alignment 
Range on Protein: 242-384
Range on HMM: 36-240/243.0
PAFPVQILPYLYLGCA--------KDSTNLDVLGKYGIKYILNVTPNL------------------------------------------PN-AFEHGGE
.|  ....|.|.....        .. .... | ..||..|...|.                                            ..   ..   
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

FTYKQIPISDH---W-SQNLSQFFPEAISFIDE-----ARSKKCGVLVHCLAGISRSVTVTVAYLMQKM-NLSLNDAYDFVKRKKSN-ISPNFNFMGQLL
. | ..|. ||      ..| .|. |...||.|     |....  ||||| ||..|. |. .|||| .. ...| .|.......... . ...... .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

DFERT
.... 
ealle
subfamily_STYXL1_pd Subfamily STYXL1 243-385 1e-26 87.0 In-house 9-153 (157) alignment 
Range on Protein: 243-385
Range on HMM: 9-153/157.0
AFPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGE-FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVT
 .||..||  ||||  |...|  .     .|  .||. .  . ..   .     .|...|.   .| ... ||..||.. . ..  |||    |||||..
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

VTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
| .|||| . ...|..||...|. |.|. || .|. || ..|..|
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0040439 (Phosphotyrosine protein) phosphatases II 263-385 1e-26 89.5 In-house 71-245 (249) alignment 
Range on Protein: 263-385
Range on HMM: 71-245/249.0
LDVLGKYGIKYILNVTPNLPNAF-----------------------------------------EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEAR
.. | ..||..|...|.  .. .                                         ..| ..|...|.. |   ......|.....||...|
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr

S------KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
.      |.. ||||| ||..|. |. .||||      . ...| .|........... .|.... .|..... |
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 252-385 2.1e-26 85.7 In-house 6-141 (145) alignment 
Range on Protein: 252-385
Range on HMM: 6-141/145.0
LYLGCAKDSTNLDVLGKYGIKYILNVT--PNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQK
|| | |  . .. .| . ||  |.|..    .     .. ...   |  .|  | .||| | |   |||  . .  ||.|||.||.||||||.||.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

MNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
 |..| .|   |. ..    || .|. .||..|. |
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0045450 (Phosphotyrosine protein) phosphatases II 264-385 7.9e-26 86.9 In-house 125-303 (307) alignment 
Range on Protein: 264-385
Range on HMM: 125-303/307.0
DVLGKYGIKYILNVTPNLPNAFE--------------------------HGGEFTYKQIPISDH-----------------WSQNLSQFFPEAISFIDEA
  | ..|...|...|.  ....|                          | ...|. .....|.                   ......| |...||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RS------KKCGVLVHCLAGISRSVTVTVAYLMQKMN--------LSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
|.      |.. ||||| ||..|. |. .|||| ..         ..| .|........... .|.... .| .... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 247-380 4.1e-25 83.6 In-house 10-148 (151) alignment 
Range on Protein: 247-380
Range on HMM: 10-148/151.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNL-----PNAFEHGGeFTYKQIPISDHWSQNLSQFFPEAISFIDEARSK-KCGVLVHCLAGISRSVT
.. ..||.. .  . .|. | ..|||.|.|...       |. ..  | .....||| |.. ..|...|.....|......| .  ||||| ||..|. |
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VTVAYLMQkMNLSLNDAYDFVKRKKS-NISPNFNFMGQLLD
. ..|||  ...||..|......|    . ||  |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 251-384 1.6e-24 80.0 In-house 9-151 (154) alignment 
Range on Protein: 251-384
Range on HMM: 9-151/154.0
YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEH-------GGEFTYKQIPISDHWSQNLSQFFPEAISFIDEAR--SKKCGVLVHCLAGISRSVTV
.||..  . . |   | .. || ||||    .|.| .       |  . | .. . |.  ... . .  |  |||.|    .. .||||. .|.||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
 ..|||.|...||  |. ..|  .  |.||  |. ||  ||. 
lisylmdklkislslalellkdsryiikPnqGflkqleifeke
0042113 (Phosphotyrosine protein) phosphatases II 247-383 3.3e-24 81.1 In-house 49-240 (245) alignment 
Range on Protein: 247-383
Range on HMM: 49-240/245.0
QILPYLYLGCAKDSTNLD----VLGKYGIKYILNVTPNLP--------------------------------------------NAFEHGGEFTYKQIPI
.| | .... .  . ...     | ..||..|...|.  .                                              .|.   ..| ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDHWSQNLSQFFPEAISFIDEARS--KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
 ||   .|.. . ....|...|..  ..  ||||| ||..|. |. .||||       ...|| .|........... ...... .| ....
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_STYX_pd Subfamily STYX 247-383 1.3e-23 76.9 In-house 14-155 (166) alignment 
Range on Protein: 247-383
Range on HMM: 14-155/166.0
QILPYLYLGC--AKDSTNLDVLGKYGIKYILNVTPNLPNAF---EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
.||| |.||   |   . |.|| | || .|. .  |.  ..   .   .| |  . ..|   .|. ...|.  .|||.. .|   ||||  |||||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
 .||.|. . |   .|. .|....  |.||  |. || ..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0040438 (Phosphotyrosine protein) phosphatases II 266-386 1.2e-22 76.1 In-house 106-276 (317) alignment 
Range on Protein: 266-386
Range on HMM: 106-276/317.0
LGKYGIKYILNVTPNLPNA-------------------------FEHGGEFTYKQIPISDH----------------WSQNLSQFFPEAISFIDEARSK-
. ..|...|...|.  ..                          .|. ...|. .....|.                  ... . . . ..|....|.. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---KCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLG
   .. ||||| ||..|. |. .||||     ....... .|........... ...... .| |... . 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 266-384 4.6e-22 74.3 In-house 121-287 (297) alignment 
Range on Protein: 266-384
Range on HMM: 121-287/297.0
LGKYGIKYILNVTPNLPNA-----------------------FEHGGEFT-----------------YKQIPISDHWSQNLSQFFPEAISFIDEARS---
. ..|...|...|.  ..                        .|| . .|                 .  ... ||   .... . |.. ...||..   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|.. ||||| ||..|. |. .||||      . .... .|........... ...... .| |... 
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0038934 (Phosphotyrosine protein) phosphatases II 285-384 1.4e-20 69.2 In-house 74-175 (194) alignment 
Range on Protein: 285-384
Range on HMM: 74-175/194.0
FEHGGEFTYKQIPISDHWS----QNLSQFFPEAISFIDEarSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLD
  ..  ..| ..|. |...    ..| .|.  .  |..|  .... |.||| ||..|. |. .|||......|...|......|. .. || ... .|| 
efekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

FERT
. ..
ryke
subfamily_MSG5_pd Subfamily MSG5 301-385 3.6e-19 62.5 In-house 77-160 (165) alignment 
Range on Protein: 301-385
Range on HMM: 77-160/165.0
HWSQnLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
| |. . . ...  . |  |.||.  .||||  |.||| .. |||.|.  ||||.|||| .| .  .|||.. .. ||...| .|
hdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0051429 (Phosphotyrosine protein) phosphatases II 253-383 3.6e-18 61.7 In-house 25-222 (272) alignment 
Range on Protein: 253-383
Range on HMM: 25-222/272.0
YLGCAK---DSTNLDVLGKYGIKYILNVTPNL----PNAFEHGGEFTYKQIPISDHWSQNLSQFF-----------------------------------
|.. .    .  ... | ..|||.|.....       . . .   ..| ..|| |.  .  ....                                   
yrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

-------------PEAISFIDEARSkKCGVLVHCLAGISRSVTVTVAYLMQkMNLS--------------LNDAYDFVKRKKSNISPNFNFMGQLLDFER
              . ...... .. .  ||||| ||..|. || ...|.  ...|              | .|.. ....  .. ..  .. .|.....
lhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0036941 (Phosphotyrosine protein) phosphatases II 268-385 2.3e-17 58.7 In-house 100-276 (297) alignment 
Range on Protein: 268-385
Range on HMM: 100-276/297.0
KYGIKYILNVTPNLPNAF---------------------------------------------EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARS
..... |...|.  .. .                                             . | ..| ... . .    .. . . . ..||...|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KKCGVLVHCLAGISRSVTVTVAYLM--------QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
      ..  ||||| ||..|| |. .|.||           .... .|. ...... .. ...... .| ...  |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 269-383 2e-16 55.7 In-house 156-274 (278) alignment 
Range on Protein: 269-383
Range on HMM: 156-274/278.0
YGIKYILNVTPNLPNAFEHGGEFTYKQIPisDHWSQ-NLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVK
. . . |.||..  .   ..  . |. .|  ||    .||...     ...  ....  ||||| ||..|. |. ..||.        ...| .|.....
dytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

RKKSNISPNFNFMGQLLDFER
... .. ...... .| ....
eqRpgavqtpsqyrflyeall
subfamily_PTPMT1_pd Subfamily PTPMT1 291-381 3.3e-16 54.2 In-house 74-164 (171) alignment 
Range on Protein: 291-381
Range on HMM: 74-164/171.0
FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDF
 .. |... |.  .   .   ... ||.. .||.  | ||| || .|| |.  .|||.| .||...| ...|.|.. |  . . . .|  .
veqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey
0047943 (Phosphotyrosine protein) phosphatases II 273-379 1.9e-12 42.7 In-house 153-265 (273) alignment 
Range on Protein: 273-379
Range on HMM: 153-265/273.0
YILNVTPNLPNAFEHGGEFTYKQIPisDHWSQNLSQFFPEAISFIDEARS---KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRK
. | .|..  .   .   | |. .|  ||      . . | | ....|..   ..  |.||| ||..|. |. ...|.      . .... .|. .....
rtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

KSNISPNFNFMGQLL
. .. ...... .| 
Rpgmvqtpeqyrfly
Rhodanese Rhodanese-like domain 56-180 4.5e-12 38.5 Pfam-A 1-112 (113) alignment 
Range on Protein: 56-180
Range on HMM: 1-112/113.0
SAEWLQEELearGGASLLLLDCRPHELFESSHIETAINLAIPGLmlrrLRKGNLPIRSIIPNHaDKERFATRCKAATVLLYDeatAEWQPEPGAPASVLG
||..|.| |   .. ...|||.|. | .. .||. |.|.. . |      .. |.... ...   .|.     |  ||..|.   .  .   || |..| 
sakelkell...ekekvvllDvRspeeyakghIpgAvnvpldsl....yprrdlffkdklaee.leesgkkldkdktvvvyc...rsgnrsggaaallla

LLLQKLRDDgcQAYYLQGGFNKFQT
|.|..|  .  . |.| |||.... 
lilkelgyk..nvyvLdGGfeawka
0051299 (Phosphotyrosine protein) phosphatases II 269-373 5e-12 41.3 In-house 161-273 (288) alignment 
Range on Protein: 269-373
Range on HMM: 161-273/288.0
YGIKYILNVTPN----LPNAFEHGGEFTYKQIPisDHWSQN-LSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAY
. ... | ||..     ..   .   | |...|  ||   . .....     ...  .|... |.||| ||..|. |. ...|.     ..  ... .|.
dytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

DFVKRKKSNISPNFN
 ...... .. ....
krlreqRpgmvqtpe
subfamily_DSP23_pd Subfamily DSP23 262-365 7e-12 40.2 In-house 23-125 (148) alignment 
Range on Protein: 262-365
Range on HMM: 23-125/148.0
NLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFfPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFV
..  |   |..|.. .| . .   |   . |.... | |.    | |   | .  ..|| .|.  | |||| |  |. |.   ||... .|.  .|   |
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

KRKK
.|..
rrlr
0046845 (Phosphotyrosine protein) phosphatases II 270-371 1.2e-10 36.7 In-house 148-259 (284) alignment 
Range on Protein: 270-371
Range on HMM: 148-259/284.0
GIKYILNVTPNL-PNAFEHGGEFTYKQIPisDHWSQNLSQFFPEAISFIDEARSK---KCGVLVHCLAGISRSVTVTVAYLMQKM--------NLSLNDA
 ... | .|..  ..   .   | |...|  ||     .. . | . ...|....   .. ..||| ||..|. |. ...|. ..        .... .|
ytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

YDFVKRKKSNISPN
. ...... .   .
vkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 292-372 5.7e-10 34.5 In-house 203-285 (308) alignment 
Range on Protein: 292-372
Range on HMM: 203-285/308.0
TYKQIPisDHWSQNLSQFFPEAISFIDEARsKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNF
 |.  |  ||   .  . . . . .... . ... ..||| ||..|. |. ...|.     .. .... .|. ...... .  ...
hytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0048567 (Phosphotyrosine protein) phosphatases II 306-374 1.3e-07 26.2 In-house 56-127 (157) alignment 
Range on Protein: 306-374
Range on HMM: 56-127/157.0
LSQFFPEAISFIDEARSKKCGVLVHCLAGI---SRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNF
| .|.  . .|..  . ... . ||| ||    .|..|.  .||. ..... ..|.....    .. |    
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrda
subfamily_Laforin_pd Subfamily Laforin 291-365 7.7e-07 22.2 In-house 77-151 (183) alignment 
Range on Protein: 291-365
Range on HMM: 77-151/183.0
FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKK
..|  .|. |  ...  . .|.|. ..     |   | ||| ||. || .. . .|.  .. ||.    |.  |.
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
PTPc_DSPc_SM00012 311-354 1.2e-06 24.0 In-house 20-69 (105) alignment 
Range on Protein: 311-354
Range on HMM: 20-69/105.0
PEAISFIDEARSKKC------GVLVHCLAGISRSVTVTVAYLMQKMNLSL
 . ...... ...|        |.||| ||..|. |....... ... . 
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke
subfamily_PTEN_pd Subfamily PTEN 295-366 2.5e-06 22.6 In-house 84-157 (184) alignment 
Range on Protein: 295-366
Range on HMM: 84-157/184.0
QIPISDHWSQNLS---QFFPEAISFIDEarSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLN-DAYDFVKRKKS
..|..|| . .|.   ..  .. ....|  .||  | ||| ||  |. ...||||.... |. . .| .. .....
vypfdDhnppplelleeivediekwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 310-354 2.8e-06 21.6 In-house 195-240 (307) alignment 
Range on Protein: 310-354
Range on HMM: 195-240/307.0
FPEAISFIDEARSKKCGVLVHCLAGISRSVT-VTVAYLMQKMNLSL
   || ...  | ..  |.||| ||. || | |.......||    
nltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGi
Y_phosphatase Protein-tyrosine phosphatase 311-352 7.1e-06 21.0 Pfam-A 153-199 (235) alignment 
Range on Protein: 311-352
Range on HMM: 153-199/235.0
PEAISFIDEARSKK----CGVLVHCLAGISRSVT-VTVAYLMQKMNL
 . ...|.. ...|      |.||| ||..|. | |.. .|..... 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea
Y_phosphatase Protein-tyrosine phosphatase 311-352 7.1e-06 21.0 In-house 153-199 (235) alignment 
Range on Protein: 311-352
Range on HMM: 153-199/235.0
PEAISFIDEARSKK----CGVLVHCLAGISRSVT-VTVAYLMQKMNL
 . ...|.. ...|      |.||| ||..|. | |.. .|..... 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea