Gene DUSP16 in Homo sapiens

Synonym: MKP-7, MKP7, DUSP16

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP032_AA protein Get Run
HsapP032_AA_156-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP8_pd Subfamily DSP8 146-302 1.2e-84 275.7 In-house 2-158 (159) alignment 
Range on Protein: 146-302
Range on HMM: 2-158/159.0
CISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCL
..|||||.||..||||||.|||||.|.|||..||....||.|||||||.|||.....||.||||||.|...||.|||.||||.||.|||..||.||||.|
elsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvl

AGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQT
||||||||.|||||||...||||||||||||||||||||.|||||||.|||..|..|
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
subfamily_DSP10_pd Subfamily DSP10 155-301 1.9e-50 164.8 In-house 10-156 (159) alignment 
Range on Protein: 155-301
Range on HMM: 10-156/159.0
ANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATI
 ..  ...|| |.|| ..|  ....... .| .|||  ...|.     . .. |.||.|.  ...    .....|||.|. ..  ||||| ||||||||.
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

AIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
.|||.||....|| .||.|||||||.||||.||.||||..||.....
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
PTPc_motif_SM00404 159-297 2e-47 155.6 In-house 2-140 (140) alignment 
Range on Protein: 159-297
Range on HMM: 2-140/140.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAY
|.||||.|||| ...  |..|....|| .|.|.........  .. ..|..|..|. ..|....||| .||||.|....| ||||| ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
.|... .||.|||.||||.||.||||.||. ||..||||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP6_pd Subfamily DSP6 157-300 2.8e-47 154.2 In-house 12-156 (158) alignment 
Range on Protein: 157-300
Range on HMM: 12-156/158.0
IGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPK-PDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIA
  | .|||.||||...|  | |.... .| ||||  .  |.  .  .| ..|..|..| . ...  .. ....||..|. ..  |||||||||||| |..
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKN
.||.||.. .||..|| .||.... |||||||.|||||.|.... 
laylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0044763 (Phosphotyrosine protein) phosphatases II 142-301 1.7e-44 146.9 In-house 6-173 (178) alignment 
Range on Protein: 142-301
Range on HMM: 6-173/178.0
LVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCP------KPDFIPE--SHFLRVPVNDSFCEKILPWLDKSVDFIEKA
.|  .  . .. . .|....|||.||||.. .. ..||....||....| .....       | .  |   ..|..|. |. .  .| .... |.|||.|
rvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

K-ASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPtISPNFNFLGQLLDYEKKIKNQ
   ..|.||||| ||..||.|...||.||....||.||...|.|.|| |.||...| ||...|......
ldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
DSPc Dual specificity phosphatase, catalytic domain 166-297 3.1e-44 145.1 Pfam-A 1-133 (133) alignment 
Range on Protein: 166-297
Range on HMM: 1-133/133.0
LYLGCQRDVLnKELMQQNGIGYVLNASNTCPKPDF--IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRM
|||| . .   ..|....|| .|.|.....|.. .   .| ..||.||.|. ..|| ..|...|.|||||..... ||||| ||||||||..|||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
 .||.|||.||||.|..||||..||.|||.||.|
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 166-297 3.1e-44 145.1 In-house 1-133 (133) alignment 
Range on Protein: 166-297
Range on HMM: 1-133/133.0
LYLGCQRDVLnKELMQQNGIGYVLNASNTCPKPDF--IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRM
|||| . .   ..|....|| .|.|.....|.. .   .| ..||.||.|. ..|| ..|...|.|||||..... ||||| ||||||||..|||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
 .||.|||.||||.|..||||..||.|||.||.|
nlslneAyefvkerrskispnagflrqLleyerk
subfamily_DSP1_pd Subfamily DSP1 159-301 5.2e-44 144.2 In-house 17-159 (163) alignment 
Range on Protein: 159-301
Range on HMM: 17-159/163.0
PTR-ILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKpDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|.. ||. |||| . .  |.|.....||  .||.|.....  |    .. .....||  . |  .... ..||...|..|| ||.|| ||||||.|. .|
PvekildfLylGsetvasnleiLkslgitailnvskeldn.vfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|.||.  .||.||. |||..|. ||||..| .|||.||||....
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP14_pd Subfamily DSP14 160-302 1.5e-42 139.2 In-house 8-148 (157) alignment 
Range on Protein: 160-302
Range on HMM: 8-148/157.0
TRILPNLYLGcQRDVLNKELMQQNGIGYVLNASNTCPKpDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
..| |.|.|.  . .|.|||.....|  ..|..   |.   ... . ..|||.|.  .|. ...|. .| ||..|...|..|||| ||.||||....||.
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQT
||   .|| |||. ||..|| |.||  |  || |||||.|...
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
0048179 (Phosphotyrosine protein) phosphatases II 159-297 1.1e-38 127.6 In-house 4-143 (144) alignment 
Range on Protein: 159-297
Range on HMM: 4-143/144.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES-HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|..|||.||||.. ..|. ||....||..|.| ...........|  ..|..|. |  .  .| .|.. ..|||.| ...|.||||| ||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
|.||....||.||...|...|| . ||...| .||.|||.
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 159-298 7.6e-38 124.7 In-house 4-142 (145) alignment 
Range on Protein: 159-298
Range on HMM: 4-142/145.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDfIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAY
|..|||.||||.. ..|. ||....||..||| ..... .      ..|..|. |  .  .| .|.. ..|||.| ...|.||||| ||..|..|...||
pseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

IMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
.|.....||.||...|...|| . ||...| .|...|...
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP19_pd Subfamily DSP19 161-299 1.1e-37 123.7 In-house 14-151 (152) alignment 
Range on Protein: 161-299
Range on HMM: 14-151/152.0
RILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPdFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM
 . |.|||| |  . .|| .....| ..|| .   |.  |  . ..| ... |   ...| .|....||||.|. ..|.||||| ||.||||...|||.|
eveprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
|. ..|| ||.. |.|.||.|.||  |. || .||....
kkeelsleealelvrearpcikPneGFikqLkeyeaell
subfamily_DSP12_pd Subfamily DSP12 160-298 6.6e-37 121.3 In-house 3-143 (155) alignment 
Range on Protein: 160-298
Range on HMM: 3-143/155.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPkPDFIPESHFLR---VPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAI
.||||.||||  ..| ..||... .|  ||   ..   |.. ..   ..   ... |.  | || .||. |||||.| . .| ||||| ||.|||.|| |
srilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
||.||. ..||..|...||||.|.|.|| .|| ||  .||  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0043147 (Phosphotyrosine protein) phosphatases II 158-301 2.9e-36 120.2 In-house 18-163 (172) alignment 
Range on Protein: 158-301
Range on HMM: 18-163/172.0
GPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNT--CPKPDFIPESHFLRVPVNDSFCEkILPWLDKSVDFIEK--AKASNGCVLVHCLAGISRSAT
 |.|.........  .  . ......||....|. .    |.. .    ..|..|. |  .  .| .|.. ..||..  |. ..|.||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

IAIAYIMKrMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
...||.|. ...||.||...|.|||| ...|.... .|...||.....
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
0041856 (Phosphotyrosine protein) phosphatases II 156-300 4.2e-36 119.6 In-house 16-174 (182) alignment 
Range on Protein: 156-300
Range on HMM: 16-174/182.0
NIGPTRILPNLYLGCQRD--------------VLNKELMQQNGIGYVLNASNTCPKPDFIPES--HFLRVPVNDSFCEKilpwLDKSVDFIEKAKASNGC
......|..|||||....                . ......||....|... .  |.. .    ..|..|. |  .      ||. .||||......|.
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRP--TISPNFNFLGQLLDYEKKIKN
||||| ||..|..|...||.||....||.||...|...||   |.||..|. ||. .|..  .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0049772 (Phosphotyrosine protein) phosphatases II 155-298 1.4e-35 118.9 In-house 122-273 (314) alignment 
Range on Protein: 155-298
Range on HMM: 122-273/314.0
ANIGP---------------------TRILPNLYlgCQRDVLNKELMQqngigyvlnaSNTCPKPDFIPE-SHFLRVPVNDsFCEKILPWLDKSVDFIEK
 .|..                      .||. ..  .. .. . ||..          . ......|  .  ..||.|| | ... .| ..|. ..|||.
rdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefiee

AkASNGCVLVHCLAGISRSAT-IAIAYIMKRMDMSLDEAYRFVKEKRPtISPNFNFLGQLLDYEKKI
|   .|.||||| ||..|..| ...||.||....||.||...|..||| |.||..|. ||..||.. 
a.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0049260 (Phosphotyrosine protein) phosphatases II 159-299 1.4e-33 111.1 In-house 8-150 (152) alignment 
Range on Protein: 159-299
Range on HMM: 8-150/152.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES--HFLRVPVNDSFCEKILPWLDKSVDFIEK-AKASNGCVLVHCLAGISRSATIA
|.........|..    ........||.....  . .... .  |   ..|..|. |. . ..  .|.  ..|||| |. ..|.||||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYIMKrMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
.||.|. ...||.||...|.|||| . ||...| .|...||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekllk
subfamily_DSP15_pd Subfamily DSP15 160-301 1.5e-33 110.0 In-house 3-142 (151) alignment 
Range on Protein: 160-301
Range on HMM: 3-142/151.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNtcPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
...||.||||  ||  ..||.... |  .|. ..   .  .... ... ....|.   |.  ....||.|| |..  .. ||||||||.|||.|...||.
skvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|  ....  .| ...|..| .  ||| |  || .|||.  ..
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_Slingshot_pd Subfamily Slingshot 159-298 2.3e-33 109.0 In-house 19-157 (169) alignment 
Range on Protein: 159-298
Range on HMM: 19-157/169.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPkpDFIPES-HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
...|   .||| . .  | | ...||. |.|| .. .   .| ||. ..|.. | |.  ...|.. ... .||||||...  |||||  |.||||.. ||
askifdhvylGsewnasnleelkengveyilnvtkeid..nffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
| ||. ..||.||...|||.|  | || .|| ||  ||  .
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
0037934 (Phosphotyrosine protein) phosphatases II 156-297 7.1e-31 103.0 In-house 36-240 (243) alignment 
Range on Protein: 156-297
Range on HMM: 36-240/243.0
NIGPTRILPNLYLGCQ--------RDVLNKELMQQNGIGYVLNASNTC--------------------------------------------PKPDFIPE
| . ....|.|.....        ..  . ......||.....  ...                                            ... .   
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

SHFLRVPVND----SFCEKILPWLDKSVDFIEK-----AKASNGCVLVHCLAGISRSATIAIAYIMKRM-DMSLDEAYRFVKEKRPT-ISPNFNFLGQLL
 |....|. |    . .| .| .||.  .|||.     |  |.| ||||| ||..|..|...||.|... ...|.||.....|.||  . ...... .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

DYEKK
.....
ealle
0046846 (Phosphotyrosine protein) phosphatases II 156-299 1.9e-30 101.3 In-house 9-173 (176) alignment 
Range on Protein: 156-299
Range on HMM: 9-173/176.0
NIGPTRILPNLYLGCQR----------DVLNKELMQQNGIGYVLNASNTCPK-----PDFIPE-----SHFLRVPVNDSFCEKIlPWLDKSVDFIEKAKA
. ....|..||.||.               . |.....||..|.|  .   .     |.. ||      ..|..|. |  .  .  .|.. ..||..|  
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

SNGCVLVHCLAGISRSATIAIAYIMKR-MDMSLDEAYRFVKEKRP-TISPNFNFLGQLLDYEKKIK
..|.||||| |||.|..|...||.... ...|..||...|.|.||  . ...... .| ..|....
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 157-299 2.8e-30 99.3 In-house 118-259 (263) alignment 
Range on Protein: 157-299
Range on HMM: 118-259/263.0
IGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRV-PVNDSFCEKILPWLDKSVDFIEKAKASnGCVLVHCLAGISRSATIA
. |  |...|.||..    || .....|. ..| |   . .| |     .| .  ..|    .|  ....   |||. . . | ||||| ||.|||.|. 
svPdeiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsstlv

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
|.|.||.  . . ||. .|..||| | ||  |. ||. ||||. 
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP3_pd Subfamily DSP3 162-301 6e-30 98.0 In-house 14-160 (162) alignment 
Range on Protein: 162-301
Range on HMM: 14-160/162.0
ILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTC-----PKPDFIPES--HFLRVPVNDSFCEKILPWLDKSVDFIEKAKAS-NGCVLVHCLAGISRSAT
. |.||.| .    .|. ... || .||||...       ...|  ..  ..| ..|.|..  ..  . .....||..| .. .| ||||| .|.|||||
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

IAIAYIMKRMDMSLDEAYRFVKEKRpTISPNFNFLGQLLDYEKKIKNQ
...||.| | .|.| || | |..|| .| ||  || || ......|..
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrk
0036282 (Phosphotyrosine protein) phosphatases II 156-299 1.1e-29 98.7 In-house 9-170 (174) alignment 
Range on Protein: 156-299
Range on HMM: 9-170/174.0
NIGPTRILPNLYLGCQRDVlNKELMQQNGIGYVLNASNTCPKP--------------DFIPESHFLRVPVNDSFCEKILPwLDKSVDFIEKAKAS--NGC
... ..|.|.|..|.     . |.....|| .|..  . ...                     ..|..|. |  .  .   |.. |.|.|.| ..  .|.
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

VLVHCLAGISRSATIAIAYIMKRMDM-SLDEAYRFVKEKR---PTISPNFNFLGQLLDYEKKIK
||||| ||..|..|...||.|.|. . ||..|...|.|.|   | . ...... .| ..||...
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls
PTEN_1 150-300 3.4e-29 97.1 In-house 36-193 (196) alignment 
Range on Protein: 150-300
Range on HMM: 36-193/196.0
PCLPVANigptRILPNLYLGCQRDV-LNKELMQQNGIGYVLNASNTCPK------PDFIPESHFL--RVPVNDSFCEKILPWLDKSVDFIEKAKA-S-NG
|..|.      .| ..||.| ..||  ... ....||  |.| |. ..       ...  .|..   ..|..|     .  ..|  ..||| ... . ..
psrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngn

CVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKN
.||||| ||..||.|...|| |... .. ||| ..|.|||| ..||  .. .|| |......
vVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0045098 (Phosphotyrosine protein) phosphatases II 158-299 1.3e-28 95.7 In-house 21-272 (278) alignment 
Range on Protein: 158-299
Range on HMM: 21-272/278.0
GPTRILPNLYLGCQR-----------------------------------------DVLNKELMQQNGIGYVLNASN-----------------------
 | .|.|.||||..                                             . ......|| ..... .                       
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------TCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA--------------SNGCVLVHCLAGISRS
                            .  .. ..   |.| .| ...  . || .... ..||..| .              |.|.||||| ||..|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ATIAIAYIMKRM---DMSLDEAYRFVKEKRPT-ISPNFNFLGQLLDYEKKIK
.|...||.|...    ..|.||.......||  . .|.... .| ... .. 
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_MKPLT_pd Subfamily MKPLT 159-297 3.2e-27 89.1 In-house 21-159 (164) alignment 
Range on Protein: 159-297
Range on HMM: 21-159/164.0
PTRILP-NLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|. .|. .||||   .. |......  | ...| |. . |  |     .|.| |.|   |.. ..|..  .|. .|  | |.|||||  | |||.....|
psvvledtlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
...|     |.||| ..||.|  ..||  || ||  .|. 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 159-297 3.2e-27 89.1 In-house 21-159 (164) alignment 
Range on Protein: 159-297
Range on HMM: 21-159/164.0
PTRILP-NLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|. .|. .||||   .. |......  | ...| |. . |  |     .|.| |.|   |.. ..|..  .|. .|  | |.|||||  | |||.....|
psvvledtlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
...|     |.||| ..||.|  ..||  || ||  .|. 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
0042113 (Phosphotyrosine protein) phosphatases II 157-297 6.1e-27 90.0 In-house 45-241 (245) alignment 
Range on Protein: 157-297
Range on HMM: 45-241/245.0
IGPTRILPNLYLGCQRDVLNKE----LMQQNGIGYVLNASNTC---------------------------------------------PKPDFIPESHFL
..  || |..... .    . |    .....|| .... ...                                              ...      |..
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

RVPVNDSFCEKILPWLDKSVDFIEKAKA--SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
..|. |  .  .| .|.. ..|..|| |  ||| ||||| ||..|..|...||.|     |....||.||.......|| . ...... .| .....
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 165-299 5.5e-26 84.8 In-house 9-153 (154) alignment 
Range on Protein: 165-299
Range on HMM: 9-153/154.0
NLYLGCQRDVLNKELMQQNGIGYVLNA----SNTCPKP------DFIpeSHFLRVPVNDSFCEKILPWLDKSVDFIEKAK--ASNGCVLVHCLAGISRSA
.||.. .   ||| ..|.. |  .||     .|  ..        ||   ..|.. . |    .|.  |||. .||..|     |. ||||. .|.||||
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfi..ieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
...|.|.|... .|| .|. ..|. |. |.||  || ||  .||. .
allisylmdklkislslalellkdsryiikPnqGflkqleifekell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 165-297 1.3e-25 83.6 In-house 14-146 (148) alignment 
Range on Protein: 165-297
Range on HMM: 14-146/148.0
NLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMD
 |.|| ..  .. | ... |.  . ||.. ....      ..| |...|   | .    .. ..|..|||.  . ||||.  |.|||. .|......  .
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
.|| ||. .||.||. . ||  || || ..|..
vslkealalvkskrryvdpnlgfLkqLaeleqa
0040439 (Phosphotyrosine protein) phosphatases II 177-297 1.9e-25 85.3 In-house 71-244 (249) alignment 
Range on Protein: 177-297
Range on HMM: 71-244/249.0
KELMQQNGIGYVLNASNTCPKP------------------------------------------DFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAK
 ......||............                                            . .. . | ... |    .. |...  .||||...
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr

A------SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
       ..|.||||| ||..|..|...||.|     |. ...|.||.......|| . .|.... .|......
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 178-327 5e-25 83.9 In-house 104-304 (317) alignment 
Range on Protein: 178-327
Range on HMM: 104-304/317.0
ELMQQNGIGYVLNASNTCPKP--------------------------DFIPESHFLRVPVNDS----------------FCEKILPWLDKSVDFIEKAKA
......|......  .....                           .  .. . ....| |.                   .. |..|  .||.|....
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

S----NGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAV
.    .|.||||| ||..|..|...||.|     |.......||.....|.|| . ...... .| |.. .. . .. . | |.|||..|. ......  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

S
.
v
subfamily_STYX_pd Subfamily STYX 161-296 1.7e-24 79.8 In-house 14-155 (166) alignment 
Range on Protein: 161-296
Range on HMM: 14-155/166.0
RILPNLYLGCQRDVLNKE--LMQQNGIGYVL----NASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATI
 ||| |.||     ..     ....|| ...    |   .  ||.|  . ..| . | |.  |.|. .| .  .||...  . | ||||  |||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

AIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEK
 |||||. . .   ||...|.|.|  |.||  |  || .|| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0045450 (Phosphotyrosine protein) phosphatases II 178-297 2.8e-24 81.9 In-house 125-302 (307) alignment 
Range on Protein: 178-297
Range on HMM: 125-302/307.0
ELMQQNGIGYVLNASNTCPKPD---------------------------FIPESHFLRVPVNDS-----------------FCEKILPWLDKSVDFIEKA
......|...... ...... .                             .. . ....| |.                    .. |...  .||||..
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KA------SNGCVLVHCLAGISRSATIAIAYIMKRMD--------MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
..      ..|.||||| ||..|..|...||.|.|.         ..|.||.....|.|| . .|.... .| .....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 159-301 3.5e-24 78.8 In-house 11-156 (157) alignment 
Range on Protein: 159-301
Range on HMM: 11-156/157.0
PTRILPN-LYLGCQRDVLNKELMQQNGIGYVLNASNTC-PKPDFIPE-SHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIA
|  .||. ||||  ..  |... .   .  ..| |. . .  . ... .. |...|.|.   ..|. |.. |.|||| | .. .|||    ||||||...
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|||.|   ...| .|| ..|. .. . || .|. || ..||.. ..
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0051082 (Phosphotyrosine protein) phosphatases II 160-295 5.5e-23 76.7 In-house 9-150 (151) alignment 
Range on Protein: 160-295
Range on HMM: 9-150/151.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTC---PKPDFIPE--SHFLRVPVNDSFCEKILPWLDKSVDFIEKAKAS-NGCVLVHCLAGISRSAT
... ..||.. .    . ||....|| ...|  ..      |.. ||   ..|..|. |    ..  ..|  ..|.|.. .  ||.||||| ||..|..|
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

IAIAYIMKrMDMSLDEAYRFVKEKRP-TISPNFNFLGQLLDYE
....|.|. ...||.||......|||  . ||  || ||....
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall
0039614 (Phosphotyrosine protein) phosphatases II 178-298 1.4e-22 75.9 In-house 119-288 (297) alignment 
Range on Protein: 178-298
Range on HMM: 119-288/297.0
ELMQQNGIGYVLNASNTCPK----------------------PDFIPES-------------------HFLRVPVNDSFCEKILPWLDKSVDFIEKAKA-
......|. ....  .....                       ... ..                   ||. ..  |  .  .|  |.. ......| | 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
  ..|.||||| ||..|..|...||.|     |. .....||.....|.|| . ...... .| |.... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0038934 (Phosphotyrosine protein) phosphatases II 173-301 2e-22 75.2 In-house 45-179 (194) alignment 
Range on Protein: 173-301
Range on HMM: 45-179/194.0
DVLNKELMQQNGIGYV--LNASNTCPKPDFIPES--HFLRVPVNDSFC----EKILPWLDKSVDFIekAKASNGCVLVHCLAGISRSATIAIAYIMKRMD
|...    .. ..|.|  |. ....  |. ....  ..|. |. | ..    | .| .||   .|.  .. ..|.|.||| ||..|..|...||...|..
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlg

MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
||..||.....|||| . || ..| .|| . | ....
msaeeAialfrekRpgaipnqdyleallkrykelrka
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 222-301 2.1e-21 69.5 In-house 65-144 (145) alignment 
Range on Protein: 222-301
Range on HMM: 65-144/145.0
WLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
 .|.  |||.| |     |.|||.||.||| |...|..||  .|.| || | |. .|    || .|| .||. ||..|..
hfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
0051429 (Phosphotyrosine protein) phosphatases II 160-298 4.1e-21 71.3 In-house 17-224 (272) alignment 
Range on Protein: 160-298
Range on HMM: 17-224/272.0
TRILPNLYLGCQR----DVLNKELMQQNGIGYVLNASNTC----PK-PDFIPESHFLRVPVNDSFCEKILPWL---------------------------
 ...|.... ...    .. . . ....|| ....  ...     | . ..|  ..|..|..|.  . || .                            
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------DKSVDFIEKAKAsNGCVLVHCLAGISRSATIAIAYIMKrMDMS--------------LDEAYRFVKEKRPTISPNFNFL
                     .  ....|   . .| ||||| ||..|..|.. ....  ...|              |.||.. ....|| . ..  ..
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

GQLLDYEKKI
 .|.......
lflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 178-295 1.5e-20 69.3 In-house 151-273 (278) alignment 
Range on Protein: 178-295
Range on HMM: 151-273/278.0
ELMQQNGIGYVLNASN-TCPKPDFIPESHFLRVPvNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAY
|  ... . ..|. .|  .... ..   |.| .|  ....| . . ||   ...|. . |||.||||| ||..|..|....|..     |.  ..|.||.
eehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeav

RFVKEKRPTISPNFNFLGQLLDYE
....|.|| . ...... .| ...
kelreqRpgavqtpsqyrflyeal
0036941 (Phosphotyrosine protein) phosphatases II 218-298 6.3e-20 67.1 In-house 182-276 (297) alignment 
Range on Protein: 218-298
Range on HMM: 182-276/297.0
KILPWLDKSVDFIEKAKA------SNGCVLVHCLAGISRSATIAIAYIM--------KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
.. .. .  .||||...       |.| ||||| ||..||.|...|..|        |.  ... ||.....|.|| . ...... .| ... . 
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_PTPMT1_pd Subfamily PTPMT1 205-298 1.3e-19 65.2 In-house 75-168 (171) alignment 
Range on Protein: 205-298
Range on HMM: 75-168/171.0
HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
..|.... | . .  |  | |.|.|||| . .  .| ||| || .||||....|.||.  .|..|| ...|.||..|  . . . .|  ||.|.
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_MSG5_pd Subfamily MSG5 217-301 5.4e-17 55.4 In-house 79-163 (165) alignment 
Range on Protein: 217-301
Range on HMM: 79-163/165.0
EKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
 ||   | .    |  |.. .  .||||  |.||||.. .|||||  ..|| .||  .| .   |||.. .. ||...|  ....
skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
Rhodanese Rhodanese-like domain 16-130 1.5e-16 52.9 Pfam-A 6-112 (113) alignment 
Range on Protein: 16-130
Range on HMM: 6-112/113.0
VALLesGTEKVLLIDSRPFVEYNTSHILEAININCSKLmkrRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDqSSQDVASLSSDCFLTVLLGKLekSF
 .||  . |||.|.| |.. ||...|| .|.|.. . |   . ..|     .| .  .... ..| ...||||. .|.. ..    ..|  .| .|  ..
kell..ekekvvllDvRspeeyakghIpgAvnvpldsl...yprrdlffkdklaeeleesgkkldkdktvvvyc.rsgnrsggaaalllalilkel..gy

NSVHLLAGGFAEFSR
. |..| ||| ....
knvyvLdGGfeawka
0047943 (Phosphotyrosine protein) phosphatases II 187-291 3.1e-16 55.1 In-house 153-264 (273) alignment 
Range on Protein: 187-291
Range on HMM: 153-264/273.0
YVLNASN-TCPKPDFIPESHFLRVPvNDSFCEkilpWLDKSVDFIEKAKA------SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFV
..|  .|  .... ..   |..  | ... ..     |.  ..|||...       ||| |.||| ||..|..|.......     |.  ....||....
rtleltnlgtgesrtvthfhytgwp.dhgvpp....slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkll

KEKRPTISPNFNFLGQL
...|| . ...... .|
rsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 180-286 1.8e-15 52.6 In-house 158-273 (288) alignment 
Range on Protein: 180-286
Range on HMM: 158-273/288.0
MQQNGIGYVLNASN-----TCPKPDFIPESHFLRVPvNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDE
.... . ..|  .|      . .. ..   |..  | .... . . ..||   ..... ....|.|.||| ||..|..|.......     |.  ... |
vlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

AYRFVKEKRPTISPNFN
|.....|.|| . ....
avkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 183-284 5.4e-13 44.4 In-house 147-259 (284) alignment 
Range on Protein: 183-284
Range on HMM: 147-259/284.0
NGIGYVLNASNT--CPKPDFIPESHFLRVPVNDSF--CEKILPWLDKSVDFIEKaKASNGCVLVHCLAGISRSATIAIAYIMKRM--------DMSLDEA
. . ..|  .|.  . .. ..   |..  | ..     | .| .|..  ...|.   ..| ..||| ||..|..|..........         ... ||
dytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

YRFVKEKRPTISPN
.....|.||    .
vkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 223-285 8.6e-13 43.7 In-house 216-285 (308) alignment 
Range on Protein: 223-285
Range on HMM: 216-285/308.0
LDKSVDFIEKAKAS--NGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNF
..  .||.|... |  .| ..||| ||..|..|.......     |   ... ||.....|.||   ...
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_DSP23_pd Subfamily DSP23 179-282 3.7e-12 41.1 In-house 26-129 (148) alignment 
Range on Protein: 179-282
Range on HMM: 26-129/148.0
LMQQNGIGYVLNASNTC-PKPDFIPESHFLRVPVNDsFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEK
 . ..|. |..  .. . |. . .|.  . |. ..| ..   |  ... |  .|.|.. |  | |||| |  |. |.   |..|  ...  ||   |...
ylldlgvrylvslteegrphveatpnltlvrlridd.yhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RPTIS
||   
rpgsv
0048567 (Phosphotyrosine protein) phosphatases II 222-286 1e-09 32.9 In-house 59-126 (157) alignment 
Range on Protein: 222-286
Range on HMM: 59-126/157.0
WLDKSVDFIEKAKASNGCVLVHCLAGI---SRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFN
.  |  .|..  .  .. . ||| ||    .|.||.. .|........ .||.....  ||.. |   
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd
subfamily_CDC14_pd Subfamily CDC14 228-283 9.7e-08 26.2 In-house 254-311 (328) alignment 
Range on Protein: 228-283
Range on HMM: 254-311/328.0
DFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPT--ISP
 |.| |. ..| . ||| ||. |  |.  .|.||.  ..  ||  ...  ||   |.|
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigp
PTPc_DSPc_SM00012 217-263 2.5e-07 26.2 In-house 20-65 (105) alignment 
Range on Protein: 217-263
Range on HMM: 20-65/105.0
EKILPWLDKSVDFIEKAKAsNGCVLVHCLAGISRSATIAIAYIMKRM
..|| .|..  .. .|..  .. |.||| ||..|..|.. ..|. ..
dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq
subfamily_RNGTT_pd Subfamily RNGTT 234-293 6.6e-07 23.2 In-house 110-169 (189) alignment 
Range on Protein: 234-293
Range on HMM: 110-169/189.0
KASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLD
| ..  . |||  |  |.  ....|.....|.|...| .  .. ||    . ..| .||.
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellr
Y_phosphatase Protein-tyrosine phosphatase 224-271 1.4e-06 23.3 Pfam-A 153-209 (235) alignment 
Range on Protein: 224-271
Range on HMM: 153-209/235.0
DKSVDFIEKAKASN----GCVLVHCLAGISRSAT-IAIAYIMKRMDM----SLDEAY
.. .|.|.| . |.    | |.||| ||..|..| .|. .......     .. .. 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv
Y_phosphatase Protein-tyrosine phosphatase 224-271 1.4e-06 23.3 In-house 153-209 (235) alignment 
Range on Protein: 224-271
Range on HMM: 153-209/235.0
DKSVDFIEKAKASN----GCVLVHCLAGISRSAT-IAIAYIMKRMDM----SLDEAY
.. .|.|.| . |.    | |.||| ||..|..| .|. .......     .. .. 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv
subfamily_Laforin_pd Subfamily Laforin 207-281 1.5e-06 21.2 In-house 80-154 (183) alignment 
Range on Protein: 207-281
Range on HMM: 80-154/183.0
LRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTI
. .|..|   |  .  | ..| ..         | ||| ||. ||..|   ...  .. ||     |.  |||..
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTPDC1_pd Subfamily PTPDC1 235-280 1.6e-06 22.7 In-house 112-157 (182) alignment 
Range on Protein: 235-280
Range on HMM: 112-157/182.0
ASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPT
 ..| | ||| ||  |   .  .|..   ... ..| ..|..||| 
lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_PRL_pd Subfamily PRL 233-296 2.3e-06 21.7 In-house 86-147 (151) alignment 
Range on Protein: 233-296
Range on HMM: 86-147/151.0
AKASNGCVLVHCLAGISRSAT-IAIAYIMKrmDMSLDEAYRFVKEKRPTiSPNFNFLGQLLDYEK
..... .| |||.||. |.   .|.| | .   |. ..| .|..|||   . | . |  | .| .
keepkstvavhcvaGlGraPvlvalaliea..Gmkyedavefirekrrg.ainskqlkflekyka
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 226-263 6.7e-06 20.3 In-house 198-236 (307) alignment 
Range on Protein: 226-263
Range on HMM: 198-236/307.0
SVDFIEKAKASNGCVLVHCLAGISRSATI-AIAYIMKRM
.....|  .  .  |.||| ||. || || ||.... .|
ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkm
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 227-259 8.9e-06 20.0 In-house 181-213 (290) alignment 
Range on Protein: 227-259
Range on HMM: 181-213/290.0
VDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
.. |.| |||.  |.|||  ||||||..|   .
lsliqkvkasktpvivHcvdGiSrsAalaaiil