Gene DUSP16 in Homo sapiens

Synonym: MKP-7, MKP7, DUSP16

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP032_AA protein Get Run
HsapP032_AA_156-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP8_pd Subfamily DSP8 146-302 1.2e-84 275.7 In-house 2-158 (159) alignment
Range on Protein: 146-302
Range on HMM: 2-158/159.0
CISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCL
..|||||.||..||||||.|||||.|.|||..||....||.|||||||.|||.....||.||||||.|...||.|||.||||.||.|||..||.||||.|
elsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvl

AGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQT
||||||||.|||||||...||||||||||||||||||||.|||||||.|||..|..|
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt

subfamily_DSP10_pd Subfamily DSP10 155-301 1.9e-50 164.8 In-house 10-156 (159) alignment
Range on Protein: 155-301
Range on HMM: 10-156/159.0
ANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATI
 ..  ...|| |.|| ..|  ....... .| .|||  ...|.     . .. |.||.|.  ...    .....|||.|. ..  ||||| ||||||||.
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

AIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
.|||.||....|| .||.|||||||.||||.||.||||..||.....
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks

PTPc_motif_SM00404 159-297 2e-47 155.6 In-house 2-140 (140) alignment
Range on Protein: 159-297
Range on HMM: 2-140/140.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAY
|.||||.|||| ...  |..|....|| .|.|.........  .. ..|..|..|. ..|....||| .||||.|....| ||||| ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
.|... .||.|||.||||.||.||||.||. ||..||||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk

subfamily_DSP6_pd Subfamily DSP6 157-300 2.8e-47 154.2 In-house 12-156 (158) alignment
Range on Protein: 157-300
Range on HMM: 12-156/158.0
IGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPK-PDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIA
  | .|||.||||...|  | |.... .| ||||  .  |.  .  .| ..|..|..| . ...  .. ....||..|. ..  |||||||||||| |..
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKN
.||.||.. .||..|| .||.... |||||||.|||||.|.... 
laylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl

0044763 (Phosphotyrosine protein) phosphatases II 142-301 1.7e-44 146.9 In-house 6-173 (178) alignment
Range on Protein: 142-301
Range on HMM: 6-173/178.0
LVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCP------KPDFIPE--SHFLRVPVNDSFCEKILPWLDKSVDFIEKA
.|  .  . .. . .|....|||.||||.. .. ..||....||....| .....       | .  |   ..|..|. |. .  .| .... |.|||.|
rvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieea

K-ASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPtISPNFNFLGQLLDYEKKIKNQ
   ..|.||||| ||..||.|...||.||....||.||...|.|.|| |.||...| ||...|......
ldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke

DSPc Dual specificity phosphatase, catalytic domain 166-297 3.1e-44 145.1 Pfam-A 1-133 (133) alignment
Range on Protein: 166-297
Range on HMM: 1-133/133.0
LYLGCQRDVLnKELMQQNGIGYVLNASNTCPKPDF--IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRM
|||| . .   ..|....|| .|.|.....|.. .   .| ..||.||.|. ..|| ..|...|.|||||..... ||||| ||||||||..|||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
 .||.|||.||||.|..||||..||.|||.||.|
nlslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 166-297 3.1e-44 145.1 In-house 1-133 (133) alignment
Range on Protein: 166-297
Range on HMM: 1-133/133.0
LYLGCQRDVLnKELMQQNGIGYVLNASNTCPKPDF--IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRM
|||| . .   ..|....|| .|.|.....|.. .   .| ..||.||.|. ..|| ..|...|.|||||..... ||||| ||||||||..|||.||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
 .||.|||.||||.|..||||..||.|||.||.|
nlslneAyefvkerrskispnagflrqLleyerk

subfamily_DSP1_pd Subfamily DSP1 159-301 5.2e-44 144.2 In-house 17-159 (163) alignment
Range on Protein: 159-301
Range on HMM: 17-159/163.0
PTR-ILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKpDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|.. ||. |||| . .  |.|.....||  .||.|.....  |    .. .....||  . |  .... ..||...|..|| ||.|| ||||||.|. .|
PvekildfLylGsetvasnleiLkslgitailnvskeldn.vfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|.||.  .||.||. |||..|. ||||..| .|||.||||....
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle

subfamily_DSP14_pd Subfamily DSP14 160-302 1.5e-42 139.2 In-house 8-148 (157) alignment
Range on Protein: 160-302
Range on HMM: 8-148/157.0
TRILPNLYLGcQRDVLNKELMQQNGIGYVLNASNTCPKpDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
..| |.|.|.  . .|.|||.....|  ..|..   |.   ... . ..|||.|.  .|. ...|. .| ||..|...|..|||| ||.||||....||.
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQT
||   .|| |||. ||..|| |.||  |  || |||||.|...
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks

0048179 (Phosphotyrosine protein) phosphatases II 159-297 1.1e-38 127.6 In-house 4-143 (144) alignment
Range on Protein: 159-297
Range on HMM: 4-143/144.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES-HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|..|||.||||.. ..|. ||....||..|.| ...........|  ..|..|. |  .  .| .|.. ..|||.| ...|.||||| ||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
|.||....||.||...|...|| . ||...| .||.|||.
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0048076 (Phosphotyrosine protein) phosphatases II 159-298 7.6e-38 124.7 In-house 4-142 (145) alignment
Range on Protein: 159-298
Range on HMM: 4-142/145.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDfIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAY
|..|||.||||.. ..|. ||....||..||| ..... .      ..|..|. |  .  .| .|.. ..|||.| ...|.||||| ||..|..|...||
pseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

IMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
.|.....||.||...|...|| . ||...| .|...|...
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_DSP19_pd Subfamily DSP19 161-299 1.1e-37 123.7 In-house 14-151 (152) alignment
Range on Protein: 161-299
Range on HMM: 14-151/152.0
RILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPdFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM
 . |.|||| |  . .|| .....| ..|| .   |.  |  . ..| ... |   ...| .|....||||.|. ..|.||||| ||.||||...|||.|
eveprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
|. ..|| ||.. |.|.||.|.||  |. || .||....
kkeelsleealelvrearpcikPneGFikqLkeyeaell

subfamily_DSP12_pd Subfamily DSP12 160-298 6.6e-37 121.3 In-house 3-143 (155) alignment
Range on Protein: 160-298
Range on HMM: 3-143/155.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPkPDFIPESHFLR---VPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAI
.||||.||||  ..| ..||... .|  ||   ..   |.. ..   ..   ... |.  | || .||. |||||.| . .| ||||| ||.|||.|| |
srilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
||.||. ..||..|...||||.|.|.|| .|| ||  .||  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg

0043147 (Phosphotyrosine protein) phosphatases II 158-301 2.9e-36 120.2 In-house 18-163 (172) alignment
Range on Protein: 158-301
Range on HMM: 18-163/172.0
GPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNT--CPKPDFIPESHFLRVPVNDSFCEkILPWLDKSVDFIEK--AKASNGCVLVHCLAGISRSAT
 |.|.........  .  . ......||....|. .    |.. .    ..|..|. |  .  .| .|.. ..||..  |. ..|.||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

IAIAYIMKrMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
...||.|. ...||.||...|.|||| ...|.... .|...||.....
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll

0041856 (Phosphotyrosine protein) phosphatases II 156-300 4.2e-36 119.6 In-house 16-174 (182) alignment
Range on Protein: 156-300
Range on HMM: 16-174/182.0
NIGPTRILPNLYLGCQRD--------------VLNKELMQQNGIGYVLNASNTCPKPDFIPES--HFLRVPVNDSFCEKilpwLDKSVDFIEKAKASNGC
......|..|||||....                . ......||....|... .  |.. .    ..|..|. |  .      ||. .||||......|.
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRP--TISPNFNFLGQLLDYEKKIKN
||||| ||..|..|...||.||....||.||...|...||   |.||..|. ||. .|..  .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk

0049772 (Phosphotyrosine protein) phosphatases II 155-298 1.4e-35 118.9 In-house 122-273 (314) alignment
Range on Protein: 155-298
Range on HMM: 122-273/314.0
ANIGP---------------------TRILPNLYlgCQRDVLNKELMQqngigyvlnaSNTCPKPDFIPE-SHFLRVPVNDsFCEKILPWLDKSVDFIEK
 .|..                      .||. ..  .. .. . ||..          . ......|  .  ..||.|| | ... .| ..|. ..|||.
rdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefiee

AkASNGCVLVHCLAGISRSAT-IAIAYIMKRMDMSLDEAYRFVKEKRPtISPNFNFLGQLLDYEKKI
|   .|.||||| ||..|..| ...||.||....||.||...|..||| |.||..|. ||..||.. 
a.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil

0049260 (Phosphotyrosine protein) phosphatases II 159-299 1.4e-33 111.1 In-house 8-150 (152) alignment
Range on Protein: 159-299
Range on HMM: 8-150/152.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPES--HFLRVPVNDSFCEKILPWLDKSVDFIEK-AKASNGCVLVHCLAGISRSATIA
|.........|..    ........||.....  . .... .  |   ..|..|. |. . ..  .|.  ..|||| |. ..|.||||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYIMKrMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
.||.|. ...||.||...|.|||| . ||...| .|...||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekllk

subfamily_DSP15_pd Subfamily DSP15 160-301 1.5e-33 110.0 In-house 3-142 (151) alignment
Range on Protein: 160-301
Range on HMM: 3-142/151.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNtcPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
...||.||||  ||  ..||.... |  .|. ..   .  .... ... ....|.   |.  ....||.|| |..  .. ||||||||.|||.|...||.
skvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|  ....  .| ...|..| .  ||| |  || .|||.  ..
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke

subfamily_Slingshot_pd Subfamily Slingshot 159-298 2.3e-33 109.0 In-house 19-157 (169) alignment
Range on Protein: 159-298
Range on HMM: 19-157/169.0
PTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPkpDFIPES-HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
...|   .||| . .  | | ...||. |.|| .. .   .| ||. ..|.. | |.  ...|.. ... .||||||...  |||||  |.||||.. ||
askifdhvylGsewnasnleelkengveyilnvtkeid..nffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
| ||. ..||.||...|||.|  | || .|| ||  ||  .
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

0037934 (Phosphotyrosine protein) phosphatases II 156-297 7.1e-31 103.0 In-house 36-240 (243) alignment
Range on Protein: 156-297
Range on HMM: 36-240/243.0
NIGPTRILPNLYLGCQ--------RDVLNKELMQQNGIGYVLNASNTC--------------------------------------------PKPDFIPE
| . ....|.|.....        ..  . ......||.....  ...                                            ... .   
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

SHFLRVPVND----SFCEKILPWLDKSVDFIEK-----AKASNGCVLVHCLAGISRSATIAIAYIMKRM-DMSLDEAYRFVKEKRPT-ISPNFNFLGQLL
 |....|. |    . .| .| .||.  .|||.     |  |.| ||||| ||..|..|...||.|... ...|.||.....|.||  . ...... .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

DYEKK
.....
ealle

0046846 (Phosphotyrosine protein) phosphatases II 156-299 1.9e-30 101.3 In-house 9-173 (176) alignment
Range on Protein: 156-299
Range on HMM: 9-173/176.0
NIGPTRILPNLYLGCQR----------DVLNKELMQQNGIGYVLNASNTCPK-----PDFIPE-----SHFLRVPVNDSFCEKIlPWLDKSVDFIEKAKA
. ....|..||.||.               . |.....||..|.|  .   .     |.. ||      ..|..|. |  .  .  .|.. ..||..|  
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

SNGCVLVHCLAGISRSATIAIAYIMKR-MDMSLDEAYRFVKEKRP-TISPNFNFLGQLLDYEKKIK
..|.||||| |||.|..|...||.... ...|..||...|.|.||  . ...... .| ..|....
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_LRR-DSP_pd Subfamily LRR-DSP 157-299 2.8e-30 99.3 In-house 118-259 (263) alignment
Range on Protein: 157-299
Range on HMM: 118-259/263.0
IGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRV-PVNDSFCEKILPWLDKSVDFIEKAKASnGCVLVHCLAGISRSATIA
. |  |...|.||..    || .....|. ..| |   . .| |     .| .  ..|    .|  ....   |||. . . | ||||| ||.|||.|. 
svPdeiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsstlv

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
|.|.||.  . . ||. .|..||| | ||  |. ||. ||||. 
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf

subfamily_DSP3_pd Subfamily DSP3 162-301 6e-30 98.0 In-house 14-160 (162) alignment
Range on Protein: 162-301
Range on HMM: 14-160/162.0
ILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTC-----PKPDFIPES--HFLRVPVNDSFCEKILPWLDKSVDFIEKAKAS-NGCVLVHCLAGISRSAT
. |.||.| .    .|. ... || .||||...       ...|  ..  ..| ..|.|..  ..  . .....||..| .. .| ||||| .|.|||||
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

IAIAYIMKRMDMSLDEAYRFVKEKRpTISPNFNFLGQLLDYEKKIKNQ
...||.| | .|.| || | |..|| .| ||  || || ......|..
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrk

0036282 (Phosphotyrosine protein) phosphatases II 156-299 1.1e-29 98.7 In-house 9-170 (174) alignment
Range on Protein: 156-299
Range on HMM: 9-170/174.0
NIGPTRILPNLYLGCQRDVlNKELMQQNGIGYVLNASNTCPKP--------------DFIPESHFLRVPVNDSFCEKILPwLDKSVDFIEKAKAS--NGC
... ..|.|.|..|.     . |.....|| .|..  . ...                     ..|..|. |  .  .   |.. |.|.|.| ..  .|.
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

VLVHCLAGISRSATIAIAYIMKRMDM-SLDEAYRFVKEKR---PTISPNFNFLGQLLDYEKKIK
||||| ||..|..|...||.|.|. . ||..|...|.|.|   | . ...... .| ..||...
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls

PTEN_1 150-300 3.4e-29 97.1 In-house 36-193 (196) alignment
Range on Protein: 150-300
Range on HMM: 36-193/196.0
PCLPVANigptRILPNLYLGCQRDV-LNKELMQQNGIGYVLNASNTCPK------PDFIPESHFL--RVPVNDSFCEKILPWLDKSVDFIEKAKA-S-NG
|..|.      .| ..||.| ..||  ... ....||  |.| |. ..       ...  .|..   ..|..|     .  ..|  ..||| ... . ..
psrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngn

CVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKN
.||||| ||..||.|...|| |... .. ||| ..|.|||| ..||  .. .|| |......
vVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella

0045098 (Phosphotyrosine protein) phosphatases II 158-299 1.3e-28 95.7 In-house 21-272 (278) alignment
Range on Protein: 158-299
Range on HMM: 21-272/278.0
GPTRILPNLYLGCQR-----------------------------------------DVLNKELMQQNGIGYVLNASN-----------------------
 | .|.|.||||..                                             . ......|| ..... .                       
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

----------------------------TCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKA--------------SNGCVLVHCLAGISRS
                            .  .. ..   |.| .| ...  . || .... ..||..| .              |.|.||||| ||..|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ATIAIAYIMKRM---DMSLDEAYRFVKEKRPT-ISPNFNFLGQLLDYEKKIK
.|...||.|...    ..|.||.......||  . .|.... .| ... .. 
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_MKPLT_pd Subfamily MKPLT 159-297 3.2e-27 89.1 In-house 21-159 (164) alignment
Range on Protein: 159-297
Range on HMM: 21-159/164.0
PTRILP-NLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|. .|. .||||   .. |......  | ...| |. . |  |     .|.| |.|   |.. ..|..  .|. .|  | |.|||||  | |||.....|
psvvledtlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
...|     |.||| ..||.|  ..||  || ||  .|. 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfeel

subfamily_MKPLV_pd Subfamily MKPLV 159-297 3.2e-27 89.1 In-house 21-159 (164) alignment
Range on Protein: 159-297
Range on HMM: 21-159/164.0
PTRILP-NLYLGCQRDVLNKELMQQNGIGYVLNASNTCpKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIA
|. .|. .||||   .. |......  | ...| |. . |  |     .|.| |.|   |.. ..|..  .|. .|  | |.|||||  | |||.....|
psvvledtlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
...|     |.||| ..||.|  ..||  || ||  .|. 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfeel

0042113 (Phosphotyrosine protein) phosphatases II 157-297 6.1e-27 90.0 In-house 45-241 (245) alignment
Range on Protein: 157-297
Range on HMM: 45-241/245.0
IGPTRILPNLYLGCQRDVLNKE----LMQQNGIGYVLNASNTC---------------------------------------------PKPDFIPESHFL
..  || |..... .    . |    .....|| .... ...                                              ...      |..
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

RVPVNDSFCEKILPWLDKSVDFIEKAKA--SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
..|. |  .  .| .|.. ..|..|| |  ||| ||||| ||..|..|...||.|     |....||.||.......|| . ...... .| .....
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 165-299 5.5e-26 84.8 In-house 9-153 (154) alignment
Range on Protein: 165-299
Range on HMM: 9-153/154.0
NLYLGCQRDVLNKELMQQNGIGYVLNA----SNTCPKP------DFIpeSHFLRVPVNDSFCEKILPWLDKSVDFIEKAK--ASNGCVLVHCLAGISRSA
.||.. .   ||| ..|.. |  .||     .|  ..        ||   ..|.. . |    .|.  |||. .||..|     |. ||||. .|.||||
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfi..ieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIK
...|.|.|... .|| .|. ..|. |. |.||  || ||  .||. .
allisylmdklkislslalellkdsryiikPnqGflkqleifekell

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 165-297 1.3e-25 83.6 In-house 14-146 (148) alignment
Range on Protein: 165-297
Range on HMM: 14-146/148.0
NLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMD
 |.|| ..  .. | ... |.  . ||.. ....      ..| |...|   | .    .. ..|..|||.  . ||||.  |.|||. .|......  .
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
.|| ||. .||.||. . ||  || || ..|..
vslkealalvkskrryvdpnlgfLkqLaeleqa

0040439 (Phosphotyrosine protein) phosphatases II 177-297 1.9e-25 85.3 In-house 71-244 (249) alignment
Range on Protein: 177-297
Range on HMM: 71-244/249.0
KELMQQNGIGYVLNASNTCPKP------------------------------------------DFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAK
 ......||............                                            . .. . | ... |    .. |...  .||||...
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr

A------SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
       ..|.||||| ||..|..|...||.|     |. ...|.||.......|| . .|.... .|......
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 178-327 5e-25 83.9 In-house 104-304 (317) alignment
Range on Protein: 178-327
Range on HMM: 104-304/317.0
ELMQQNGIGYVLNASNTCPKP--------------------------DFIPESHFLRVPVNDS----------------FCEKILPWLDKSVDFIEKAKA
......|......  .....                           .  .. . ....| |.                   .. |..|  .||.|....
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

S----NGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAV
.    .|.||||| ||..|..|...||.|     |.......||.....|.|| . ...... .| |.. .. . .. . | |.|||..|. ......  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

S
.
v

subfamily_STYX_pd Subfamily STYX 161-296 1.7e-24 79.8 In-house 14-155 (166) alignment
Range on Protein: 161-296
Range on HMM: 14-155/166.0
RILPNLYLGCQRDVLNKE--LMQQNGIGYVL----NASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATI
 ||| |.||     ..     ....|| ...    |   .  ||.|  . ..| . | |.  |.|. .| .  .||...  . | ||||  |||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

AIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEK
 |||||. . .   ||...|.|.|  |.||  |  || .|| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

0045450 (Phosphotyrosine protein) phosphatases II 178-297 2.8e-24 81.9 In-house 125-302 (307) alignment
Range on Protein: 178-297
Range on HMM: 125-302/307.0
ELMQQNGIGYVLNASNTCPKPD---------------------------FIPESHFLRVPVNDS-----------------FCEKILPWLDKSVDFIEKA
......|...... ...... .                             .. . ....| |.                    .. |...  .||||..
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KA------SNGCVLVHCLAGISRSATIAIAYIMKRMD--------MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
..      ..|.||||| ||..|..|...||.|.|.         ..|.||.....|.|| . .|.... .| .....
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_STYXL1_pd Subfamily STYXL1 159-301 3.5e-24 78.8 In-house 11-156 (157) alignment
Range on Protein: 159-301
Range on HMM: 11-156/157.0
PTRILPN-LYLGCQRDVLNKELMQQNGIGYVLNASNTC-PKPDFIPE-SHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIA
|  .||. ||||  ..  |... .   .  ..| |. . .  . ... .. |...|.|.   ..|. |.. |.|||| | .. .|||    ||||||...
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

IAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
|||.|   ...| .|| ..|. .. . || .|. || ..||.. ..
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge

0051082 (Phosphotyrosine protein) phosphatases II 160-295 5.5e-23 76.7 In-house 9-150 (151) alignment
Range on Protein: 160-295
Range on HMM: 9-150/151.0
TRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTC---PKPDFIPE--SHFLRVPVNDSFCEKILPWLDKSVDFIEKAKAS-NGCVLVHCLAGISRSAT
... ..||.. .    . ||....|| ...|  ..      |.. ||   ..|..|. |    ..  ..|  ..|.|.. .  ||.||||| ||..|..|
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

IAIAYIMKrMDMSLDEAYRFVKEKRP-TISPNFNFLGQLLDYE
....|.|. ...||.||......|||  . ||  || ||....
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfall

0039614 (Phosphotyrosine protein) phosphatases II 178-298 1.4e-22 75.9 In-house 119-288 (297) alignment
Range on Protein: 178-298
Range on HMM: 119-288/297.0
ELMQQNGIGYVLNASNTCPK----------------------PDFIPES-------------------HFLRVPVNDSFCEKILPWLDKSVDFIEKAKA-
......|. ....  .....                       ... ..                   ||. ..  |  .  .|  |.. ......| | 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
  ..|.||||| ||..|..|...||.|     |. .....||.....|.|| . ...... .| |.... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

0038934 (Phosphotyrosine protein) phosphatases II 173-301 2e-22 75.2 In-house 45-179 (194) alignment
Range on Protein: 173-301
Range on HMM: 45-179/194.0
DVLNKELMQQNGIGYV--LNASNTCPKPDFIPES--HFLRVPVNDSFC----EKILPWLDKSVDFIekAKASNGCVLVHCLAGISRSATIAIAYIMKRMD
|...    .. ..|.|  |. ....  |. ....  ..|. |. | ..    | .| .||   .|.  .. ..|.|.||| ||..|..|...||...|..
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlg

MSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
||..||.....|||| . || ..| .|| . | ....
msaeeAialfrekRpgaipnqdyleallkrykelrka

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 222-301 2.1e-21 69.5 In-house 65-144 (145) alignment
Range on Protein: 222-301
Range on HMM: 65-144/145.0
WLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
 .|.  |||.| |     |.|||.||.||| |...|..||  .|.| || | |. .|    || .|| .||. ||..|..
hfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee

0051429 (Phosphotyrosine protein) phosphatases II 160-298 4.1e-21 71.3 In-house 17-224 (272) alignment
Range on Protein: 160-298
Range on HMM: 17-224/272.0
TRILPNLYLGCQR----DVLNKELMQQNGIGYVLNASNTC----PK-PDFIPESHFLRVPVNDSFCEKILPWL---------------------------
 ...|.... ...    .. . . ....|| ....  ...     | . ..|  ..|..|..|.  . || .                            
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------DKSVDFIEKAKAsNGCVLVHCLAGISRSATIAIAYIMKrMDMS--------------LDEAYRFVKEKRPTISPNFNFL
                     .  ....|   . .| ||||| ||..|..|.. ....  ...|              |.||.. ....|| . ..  ..
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

GQLLDYEKKI
 .|.......
lflyeallel

0043336 (Phosphotyrosine protein) phosphatases II 178-295 1.5e-20 69.3 In-house 151-273 (278) alignment
Range on Protein: 178-295
Range on HMM: 151-273/278.0
ELMQQNGIGYVLNASN-TCPKPDFIPESHFLRVPvNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAY
|  ... . ..|. .|  .... ..   |.| .|  ....| . . ||   ...|. . |||.||||| ||..|..|....|..     |.  ..|.||.
eehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeav

RFVKEKRPTISPNFNFLGQLLDYE
....|.|| . ...... .| ...
kelreqRpgavqtpsqyrflyeal

0036941 (Phosphotyrosine protein) phosphatases II 218-298 6.3e-20 67.1 In-house 182-276 (297) alignment
Range on Protein: 218-298
Range on HMM: 182-276/297.0
KILPWLDKSVDFIEKAKA------SNGCVLVHCLAGISRSATIAIAYIM--------KRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
.. .. .  .||||...       |.| ||||| ||..||.|...|..|        |.  ... ||.....|.|| . ...... .| ... . 
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

subfamily_PTPMT1_pd Subfamily PTPMT1 205-298 1.3e-19 65.2 In-house 75-168 (171) alignment
Range on Protein: 205-298
Range on HMM: 75-168/171.0
HFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKI
..|.... | . .  |  | |.|.|||| . .  .| ||| || .||||....|.||.  .|..|| ...|.||..|  . . . .|  ||.|.
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl

subfamily_MSG5_pd Subfamily MSG5 217-301 5.4e-17 55.4 In-house 79-163 (165) alignment
Range on Protein: 217-301
Range on HMM: 79-163/165.0
EKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQ
 ||   | .    |  |.. .  .||||  |.||||.. .|||||  ..|| .||  .| .   |||.. .. ||...|  ....
skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk

Rhodanese Rhodanese-like domain 16-130 1.5e-16 52.9 Pfam-A 6-112 (113) alignment
Range on Protein: 16-130
Range on HMM: 6-112/113.0
VALLesGTEKVLLIDSRPFVEYNTSHILEAININCSKLmkrRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDqSSQDVASLSSDCFLTVLLGKLekSF
 .||  . |||.|.| |.. ||...|| .|.|.. . |   . ..|     .| .  .... ..| ...||||. .|.. ..    ..|  .| .|  ..
kell..ekekvvllDvRspeeyakghIpgAvnvpldsl...yprrdlffkdklaeeleesgkkldkdktvvvyc.rsgnrsggaaalllalilkel..gy

NSVHLLAGGFAEFSR
. |..| ||| ....
knvyvLdGGfeawka

0047943 (Phosphotyrosine protein) phosphatases II 187-291 3.1e-16 55.1 In-house 153-264 (273) alignment
Range on Protein: 187-291
Range on HMM: 153-264/273.0
YVLNASN-TCPKPDFIPESHFLRVPvNDSFCEkilpWLDKSVDFIEKAKA------SNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFV
..|  .|  .... ..   |..  | ... ..     |.  ..|||...       ||| |.||| ||..|..|.......     |.  ....||....
rtleltnlgtgesrtvthfhytgwp.dhgvpp....slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkll

KEKRPTISPNFNFLGQL
...|| . ...... .|
rsqRpgmvqtpeqyrfl

0051299 (Phosphotyrosine protein) phosphatases II 180-286 1.8e-15 52.6 In-house 158-273 (288) alignment
Range on Protein: 180-286
Range on HMM: 158-273/288.0
MQQNGIGYVLNASN-----TCPKPDFIPESHFLRVPvNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDE
.... . ..|  .|      . .. ..   |..  | .... . . ..||   ..... ....|.|.||| ||..|..|.......     |.  ... |
vlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

AYRFVKEKRPTISPNFN
|.....|.|| . ....
avkrlreqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 183-284 5.4e-13 44.4 In-house 147-259 (284) alignment
Range on Protein: 183-284
Range on HMM: 147-259/284.0
NGIGYVLNASNT--CPKPDFIPESHFLRVPVNDSF--CEKILPWLDKSVDFIEKaKASNGCVLVHCLAGISRSATIAIAYIMKRM--------DMSLDEA
. . ..|  .|.  . .. ..   |..  | ..     | .| .|..  ...|.   ..| ..||| ||..|..|..........         ... ||
dytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

YRFVKEKRPTISPN
.....|.||    .
vkrlreqRpgmvqt

0050432 (Phosphotyrosine protein) phosphatases II 223-285 8.6e-13 43.7 In-house 216-285 (308) alignment
Range on Protein: 223-285
Range on HMM: 216-285/308.0
LDKSVDFIEKAKAS--NGCVLVHCLAGISRSATIAIAYIM-----KRMDMSLDEAYRFVKEKRPTISPNF
..  .||.|... |  .| ..||| ||..|..|.......     |   ... ||.....|.||   ...
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_DSP23_pd Subfamily DSP23 179-282 3.7e-12 41.1 In-house 26-129 (148) alignment
Range on Protein: 179-282
Range on HMM: 26-129/148.0
LMQQNGIGYVLNASNTC-PKPDFIPESHFLRVPVNDsFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEK
 . ..|. |..  .. . |. . .|.  . |. ..| ..   |  ... |  .|.|.. |  | |||| |  |. |.   |..|  ...  ||   |...
ylldlgvrylvslteegrphveatpnltlvrlridd.yhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RPTIS
||   
rpgsv

0048567 (Phosphotyrosine protein) phosphatases II 222-286 1e-09 32.9 In-house 59-126 (157) alignment
Range on Protein: 222-286
Range on HMM: 59-126/157.0
WLDKSVDFIEKAKASNGCVLVHCLAGI---SRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFN
.  |  .|..  .  .. . ||| ||    .|.||.. .|........ .||.....  ||.. |   
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd

subfamily_CDC14_pd Subfamily CDC14 228-283 9.7e-08 26.2 In-house 254-311 (328) alignment
Range on Protein: 228-283
Range on HMM: 254-311/328.0
DFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPT--ISP
 |.| |. ..| . ||| ||. |  |.  .|.||.  ..  ||  ...  ||   |.|
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigp

PTPc_DSPc_SM00012 217-263 2.5e-07 26.2 In-house 20-65 (105) alignment
Range on Protein: 217-263
Range on HMM: 20-65/105.0
EKILPWLDKSVDFIEKAKAsNGCVLVHCLAGISRSATIAIAYIMKRM
..|| .|..  .. .|..  .. |.||| ||..|..|.. ..|. ..
dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq

subfamily_RNGTT_pd Subfamily RNGTT 234-293 6.6e-07 23.2 In-house 110-169 (189) alignment
Range on Protein: 234-293
Range on HMM: 110-169/189.0
KASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLD
| ..  . |||  |  |.  ....|.....|.|...| .  .. ||    . ..| .||.
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellr

Y_phosphatase Protein-tyrosine phosphatase 224-271 1.4e-06 23.3 Pfam-A 153-209 (235) alignment
Range on Protein: 224-271
Range on HMM: 153-209/235.0
DKSVDFIEKAKASN----GCVLVHCLAGISRSAT-IAIAYIMKRMDM----SLDEAY
.. .|.|.| . |.    | |.||| ||..|..| .|. .......     .. .. 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

Y_phosphatase Protein-tyrosine phosphatase 224-271 1.4e-06 23.3 In-house 153-209 (235) alignment
Range on Protein: 224-271
Range on HMM: 153-209/235.0
DKSVDFIEKAKASN----GCVLVHCLAGISRSAT-IAIAYIMKRMDM----SLDEAY
.. .|.|.| . |.    | |.||| ||..|..| .|. .......     .. .. 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqiv

subfamily_Laforin_pd Subfamily Laforin 207-281 1.5e-06 21.2 In-house 80-154 (183) alignment
Range on Protein: 207-281
Range on HMM: 80-154/183.0
LRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTI
. .|..|   |  .  | ..| ..         | ||| ||. ||..|   ...  .. ||     |.  |||..
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

subfamily_PTPDC1_pd Subfamily PTPDC1 235-280 1.6e-06 22.7 In-house 112-157 (182) alignment
Range on Protein: 235-280
Range on HMM: 112-157/182.0
ASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPT
 ..| | ||| ||  |   .  .|..   ... ..| ..|..||| 
lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk

subfamily_PRL_pd Subfamily PRL 233-296 2.3e-06 21.7 In-house 86-147 (151) alignment
Range on Protein: 233-296
Range on HMM: 86-147/151.0
AKASNGCVLVHCLAGISRSAT-IAIAYIMKrmDMSLDEAYRFVKEKRPTiSPNFNFLGQLLDYEK
..... .| |||.||. |.   .|.| | .   |. ..| .|..|||   . | . |  | .| .
keepkstvavhcvaGlGraPvlvalaliea..Gmkyedavefirekrrg.ainskqlkflekyka

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 226-263 6.7e-06 20.3 In-house 198-236 (307) alignment
Range on Protein: 226-263
Range on HMM: 198-236/307.0
SVDFIEKAKASNGCVLVHCLAGISRSATI-AIAYIMKRM
.....|  .  .  |.||| ||. || || ||.... .|
ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkm

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 227-259 8.9e-06 20.0 In-house 181-213 (290) alignment
Range on Protein: 227-259
Range on HMM: 181-213/290.0
VDFIEKAKASNGCVLVHCLAGISRSATIAIAYI
.. |.| |||.  |.|||  ||||||..|   .
lsliqkvkasktpvivHcvdGiSrsAalaaiil