Gene DUSP8 in Homo sapiens

Synonym: C11orf81, HB5, HVH-5, HVH8, DUSP8

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP033_AA protein Get Run
HsapP033_AA_158-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP8_pd Subfamily DSP8 148-303 1.5e-80 262.4 In-house 2-157 (159) alignment 
Range on Protein: 148-303
Range on HMM: 2-157/159.0
SLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCL
.||||||.|..||.||||..||||||||||...|....||||||||||||||.....||.|.|||..|.|.||||||.|||.||||||| ....|.||.|
elsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvl

AGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLL
||||||||.||||||||. ||.|.||||||..||.||||.||||||||||..||||
aGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_DSP10_pd Subfamily DSP10 159-301 9.7e-51 165.8 In-house 12-154 (159) alignment 
Range on Protein: 159-301
Range on HMM: 12-154/159.0
VGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAI
. ....||.|.|||.||  ..|.. . .|..|||  .|.|.     . ...|.|..|.. ..|    ....|||..|. .. .|.||| ||||||||..|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

AYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
||.|| ...|  |||.|||..|| ||||.||.|||||.|..|.
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP6_pd Subfamily DSP6 162-302 1.2e-49 161.8 In-house 15-156 (158) alignment 
Range on Protein: 162-302
Range on HMM: 15-156/158.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKP-DFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
 .|||.|||||.||  | ..... .|.||||  .  |.  .   | .....||.|.. ..|  .. ..|||||.|. ....|.|||||||||| |...||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKL
.||.. .| .||| .||.|...|||||||.||||..||||.|
lmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
PTPc_motif_SM00404 161-298 7.8e-47 153.7 In-house 2-139 (140) alignment 
Range on Protein: 161-298
Range on HMM: 2-139/140.0
LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
 .||||||||||...  |..|....||..|.|.........   . .....|..|| ..||...||| ..||..|. . ..|.||| ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
.|.....| ..||.|||.|||.||||.||. ||.|||.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 168-298 3.2e-44 145.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 168-298
Range on HMM: 1-132/133.0
LYLGSQKDVLnKDLMTQNGISYVLNASNSCPKPDF--ICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTM
|||||...   ..|....||..|.|.....|.. .    | ...|.|..|. ..|. ..|....|||.||. . ..|.||| ||||||||..|||.|||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GMSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
..|...||.|||.||..||||..||.|||||||
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 168-298 3.2e-44 145.0 In-house 1-132 (133) alignment 
Range on Protein: 168-298
Range on HMM: 1-132/133.0
LYLGSQKDVLnKDLMTQNGISYVLNASNSCPKPDF--ICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTM
|||||...   ..|....||..|.|.....|.. .    | ...|.|..|. ..|. ..|....|||.||. . ..|.||| ||||||||..|||.|||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GMSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
..|...||.|||.||..||||..||.|||||||
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP1_pd Subfamily DSP1 162-301 1.8e-41 135.9 In-house 19-157 (163) alignment 
Range on Protein: 162-301
Range on HMM: 19-157/163.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKpDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYI
..||..|||||...  |.......||. .||.|.....  |    ........|.  . .  .... |||||..| .  .|..|| ||||||.|. .||.
ekildfLylGsetvasnleiLkslgitailnvskeldn.vfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
|||  .| ..|. |||.||. ||||..| .|||.||..|.
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 153-301 5.5e-39 129.0 In-house 15-171 (178) alignment 
Range on Protein: 153-301
Range on HMM: 15-171/178.0
CLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKP------DFICE--SRFMRVPINDNYCEKLLPWLDKSIEFIDKAK-LSSCQVI
.. ..  ....|||.|||||. .. ...|. ..||....| .. .. .       .  |   .....|| |. .  || .... .|||..|   . . |.
lersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

VHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPsISPNFNFLGQLLEYERSLK
||| ||..||.|...||.||..|.| ..|...|. ||| |.||...| ||.|.|. |.
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP14_pd Subfamily DSP14 160-301 9.4e-38 123.6 In-house 6-145 (157) alignment 
Range on Protein: 160-301
Range on HMM: 6-145/157.0
GLTRILPHLYLGsQKDVLNKDLMTQNGISYVLNASNSCPKpDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIA
.|..| |.|.|.    .|.|.|.....|. ..|..   |.   . . . ..||..||  .|| ...|. .. |...| .  ...||| ||.||||....|
alsqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
|.||.  .|  .||. ||..|| |.||  |  || .||. ||
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0048179 (Phosphotyrosine protein) phosphatases II 162-299 9.8e-35 114.7 In-house 5-143 (144) alignment 
Range on Protein: 162-299
Range on HMM: 5-143/144.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICES-RFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
..|||.|||||. ..|. .|. ..||..|.| ...........|  .....|. |. .  || .|.. .|||..|  ... |.||| ||..|..|...||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
.||..|.| ..|...|. ||| . ||...| .|||||. 
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP19_pd Subfamily DSP19 161-300 1.1e-34 114.0 In-house 12-150 (152) alignment 
Range on Protein: 161-300
Range on HMM: 12-150/152.0
LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPdFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
.. . |.||||||  . .|. . ...| ..|| .   |.  |  .  .. ..| |.  ..|| .|.....||..|. .  .|.||| ||.||||...|||
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
.||.  .|  .|.. |.. ||.|.||  |. || ||| .|
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 162-299 9.5e-34 111.0 In-house 3-142 (155) alignment 
Range on Protein: 162-299
Range on HMM: 3-142/155.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPkPDFICESRFMR---VPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAI
.|||| ||||. ..| ...|... .|. ||   .    |..  .   ..   ..| |.  | .| .||. ..||..|     .|.||| ||.|||.|| |
srilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
||.||. ..| ..|...||. .|.|.|| .|| ||  .|..
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
0048076 (Phosphotyrosine protein) phosphatases II 162-300 2.3e-33 110.3 In-house 5-142 (145) alignment 
Range on Protein: 162-300
Range on HMM: 5-142/145.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDfICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYI
..|||.|||||. ..|. .|. ..|| .||| .. .. .      .....|. |. .  || .|.. .|||..|  . . |.||| ||..|..|...||.
seilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
|...|.| ..|...|. .|| . ||...| .|.|.|. |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 161-301 2.6e-33 110.5 In-house 19-161 (172) alignment 
Range on Protein: 161-301
Range on HMM: 19-161/172.0
LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNS--CPKPDFICESRFMRVPINDNYCEkLLPWLDKSIEFIDK--AKLSSCQVIVHCLAGISRSATI
 .|.........  .  . ... ..||....|. .    |.. .    .....|. |. .  || .|.. .||||.  |. ... |.||| ||..|..|.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

AIAYIMKtMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
..||.|. .|.| ..|...|...|| ...|.... .|...|. |.
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0041856 (Phosphotyrosine protein) phosphatases II 158-300 1.8e-32 107.8 In-house 16-172 (182) alignment 
Range on Protein: 158-300
Range on HMM: 16-172/182.0
SVGLTRILPHLYLGSQKD--------------VLNKDLMTQNGISYVLNASNSCPKPDFICES--RFMRVPINDNYCEKllpwLDKSIEFIDKAKLSSCQ
| .|..|...|||||...                . ... ..||....|... .  |..      .....|. |. .      ||. ..||.... ... 
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRP--SISPNFNFLGQLLEYERSL
|.||| ||..|..|...||.||..|.| ..|...|. |||   |.||..|. ||...|. |
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Slingshot_pd Subfamily Slingshot 162-300 1.8e-32 106.1 In-house 20-157 (169) alignment 
Range on Protein: 162-300
Range on HMM: 20-157/169.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKpDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYI
..|  |.||||. .  | . . .||..|.|| .. . .  |  . ..... . |.  ..||.. ... .||.||| .  .|.|||  |.||||.. ||| 
skifdhvylGsewnasnleelkengveyilnvtkeidn.ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
||. |.| ..|...||.||  | || .|| || |||  |
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_DSP15_pd Subfamily DSP15 161-299 1.6e-31 103.4 In-house 2-138 (151) alignment 
Range on Protein: 161-299
Range on HMM: 2-138/151.0
LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKpdFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
....|| ||||  .|  ...|.... |. .|. ...  |  .. . ..  ....|    ||  ....|.||| |..|   .|.||||||.|||.|...||
iskvlpglylgnfrdskdeelLkeknithilsvhdnakk..llkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
.|  . ..  || ...| .| .  ||| |  || |||..
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0049260 (Phosphotyrosine protein) phosphatases II 162-300 2.5e-31 103.8 In-house 9-149 (152) alignment 
Range on Protein: 162-300
Range on HMM: 9-149/152.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICES--RFMRVPINDNYCEKLLPWLDKSIEFIDK-AKLSSCQVIVHCLAGISRSATIAI
.........|..    ..... ..||.....  . .... . ||   .....|. |... .|  .|.  ..||.| |. ... |.||| ||..|..|...
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYIMKtMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
||.|. .|.| ..|...|. .|| . ||...| .|.|.|. |
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0049772 (Phosphotyrosine protein) phosphatases II 162-303 4.1e-31 104.3 In-house 148-276 (314) alignment 
Range on Protein: 162-303
Range on HMM: 148-276/314.0
TRILPHLYlgSQKDVLNKDLMTqngisyvlnaSNSCPKPDFICE-SRFMRVPINDnYCEKLLPWLDKSIEFIDKAkLSSCQVIVHCLAGISRSAT-IAIA
 .||. ..  .. .. . .|.           .  .....|  .  ...|.|. | ... || ..|. .|||..|      |.||| ||..|..| ...|
llildgng..neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa

YIMKTMGMSSDDAYRFVKDRRPsISPNFNFLGQLLEYERSLKLL
|.|| .|.| ..|...|. .|| |.||..|. ||..||  |. |
ylmkllgvsleealedvrlkRp.inpnpgfieqleqyefileal
PTEN_1 149-301 4.7e-29 96.6 In-house 33-192 (196) alignment 
Range on Protein: 149-301
Range on HMM: 33-192/196.0
LSQPCLPVPSvgltRILPHLYLGSQKDV-LNKDLMTQNGISYVLNASNSCPK------PDFICESRFM--RVPINDNYCEKLLPWLDKSIEFIDKAKLSS
 . |..|...    .| ..||.||.|||  ..| . ..||  |.| |. ..       ... ..|...  ..||.|     |  ..|   .||. ... .
gkapsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdp

C--QVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
.   |.||| ||..||.|...|| |...... |.| ..|...|| ..||  .. .||||...|.
ngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0037934 (Phosphotyrosine protein) phosphatases II 159-299 5.7e-28 93.5 In-house 37-240 (243) alignment 
Range on Protein: 159-299
Range on HMM: 37-240/243.0
VGLTRILPHLYLGSQ--------KDVLNKDLMTQNGISYVLNASNSC--------------------------------------------PKPDFICES
 .|....|.|.....        ..  . ... ..||.....  . .                                            ... .    
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

RFMRVPIND----NYCEKLLPWLDKSIEFIDK-----AKLSSCQVIVHCLAGISRSATIAIAYIMKTM-GMSSDDAYRFVKDRRPS-ISPNFNFLGQLLE
.....|. |    . .| || .||. .|||..     |  |.  |.||| ||..|..|...||.|... |.. ..|.......||  . ...... .| |
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

YERS
... 
alle
subfamily_DSP3_pd Subfamily DSP3 162-301 1e-27 90.7 In-house 12-158 (162) alignment 
Range on Protein: 162-301
Range on HMM: 12-158/162.0
TRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSC-----PKPDFIC--ESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLS-SCQVIVHCLAGISRS
  . |.||.| ..   .|. ... || .||||...       ...|    | ... ....|.   .|  . ... .|||.|  . . .|.||| .|.|||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

ATIAIAYIMKTMGMSSDDAYRFVKDRRpSISPNFNFLGQLLEYERSLK
||...||.| .  |.  .| | |...| .| ||  || || |....||
atlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
0036282 (Phosphotyrosine protein) phosphatases II 158-299 1.6e-27 91.7 In-house 9-168 (174) alignment 
Range on Protein: 158-299
Range on HMM: 9-168/174.0
SVGLTRILPHLYLGSQKDVlNKDLMTQNGISYVLNASNSCPKP--------------DFICESRFMRVPINDNYCEKLLPwLDKSIEFIDKAKLS--SCQ
 ..|..|.|.|..|.     . ... ..||..|..  .....                     .....|. |. .  |   |.. ..|...| ..  .. 
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

VIVHCLAGISRSATIAIAYIMKTMGM-SSDDAYRFVKDRR---PSISPNFNFLGQLLEYERS
|.||| ||..|..|...||.|..... | .||...|. .|   | . ...... .| ..|. 
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0045098 (Phosphotyrosine protein) phosphatases II 151-300 2.2e-26 88.3 In-house 13-271 (278) alignment 
Range on Protein: 151-300
Range on HMM: 13-271/278.0
QPCLPVPSVGlTRILPHLYLGSQK-----------------------------------------DVLNKDLMTQNGISYVLNASNS-------------
   |....    .|.|.||||...                                            . ... ..||...... .              
fefllllgip.seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

--------------------------------------CPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKL--------------SSCQVIV
                                        .. ...   .. .| ..   . .| .... .|||..|                |.. |.|
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCLAGISRSATIAIAYIMKTM---GMSSDDAYRFVKDRRPS-ISPNFNFLGQLLEYERSL
|| ||..|..|...||.|...   |.. ..|..... .||  . .|.... .| |... |
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0046846 (Phosphotyrosine protein) phosphatases II 157-299 3.5e-26 87.4 In-house 8-171 (176) alignment 
Range on Protein: 157-299
Range on HMM: 8-171/176.0
PSVGLTRILPHLYLGSQK----------DVLNKDLMTQNGISYVLNASNSC-------PKPDFICE---SRFMRVPINDNYCEKLlPWLDKSIEFIDKAK
.  .|..|...|.|||               . ... ..||..|.|  .         |    ..|    .....|. |. .  |  .|.. .|||..| 
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

LSSCQVIVHCLAGISRSATIAIAYIMKT-MGMSSDDAYRFVKDRRP-SISPNFNFLGQLLEYERS
 .   |.||| |||.|..|...||.... .|.| ..|...|...||  . ...... .| |.|. 
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_STYX_pd Subfamily STYX 162-298 5.7e-26 84.6 In-house 13-155 (166) alignment 
Range on Protein: 162-298
Range on HMM: 13-155/166.0
TRILPHLYLGSQKDVLNKDL--MTQNGISYVL----NASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSAT
  ||| |.||     ..  |  . ..||....    |   .  ||.|  . |.. . . ||  |... .| .  ||||..  .  .|.||  |||||||.
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

IAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
. |||||.|.|.   .|...|..||  |.||  |  || ||| 
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0042113 (Phosphotyrosine protein) phosphatases II 159-298 3.7e-25 84.2 In-house 45-240 (245) alignment 
Range on Protein: 159-298
Range on HMM: 45-240/245.0
VGLTRILPHLYLGSQKDVLNKD----LMTQNGISYVLNASNSC---------------------------------------------PKPDFICESRFM
|.. || |.......    . .    .. ..||..... ..                                               ...      ...
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

RVPINDNYCEKLLPWLDKSIEFIDKAKL--SSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
..|. |. .  || .|.. .||..||    |.  |.||| ||..|..|...||.|     |..|.| ..|.......|| . ...... .| |...
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_MKPLT_pd Subfamily MKPLT 167-298 7.8e-25 81.3 In-house 28-158 (164) alignment 
Range on Protein: 167-298
Range on HMM: 28-158/164.0
HLYLGSQKDVLNKDLMTQNGISYVLNASNSCpKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMG
.||||  |.. |. ....  | ...| |. . |  |     ...| ..|.  |.| ..|..  .|. .|  |  .|.|||  | |||.....|...|  |
tlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
   ..|| ..|.||  ..||  || || ..|.
wtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 167-298 7.8e-25 81.3 In-house 28-158 (164) alignment 
Range on Protein: 167-298
Range on HMM: 28-158/164.0
HLYLGSQKDVLNKDLMTQNGISYVLNASNSCpKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMG
.||||  |.. |. ....  | ...| |. . |  |     ...| ..|.  |.| ..|..  .|. .|  |  .|.|||  | |||.....|...|  |
tlylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
   ..|| ..|.||  ..||  || || ..|.
wtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 167-298 1.8e-24 80.0 In-house 14-145 (148) alignment 
Range on Protein: 167-298
Range on HMM: 14-145/148.0
HLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMG
.|.|||.|  .. . . . |.. . ||.......      ... |...|.  | |    .. |.|..|||    .|.||.  |.|||. .|.......  
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MSSDDAYRFVKDRRPSISPNFNFLGQLLEYER
.|  .|. .||..|. . ||  || || |.|.
vslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_LRR-DSP_pd Subfamily LRR-DSP 163-300 6.6e-24 78.4 In-house 122-258 (263) alignment 
Range on Protein: 163-300
Range on HMM: 122-258/263.0
RILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCpKPDFICESRFMRV-PINDNYCEKLLPWLDKSIEFIDKAKlSSCQVIVHCLAGISRSATIAIAYI
 |...|.||...   || .. ..|....| |   . .| |    ... .  |.|    ..  ....   ||.. .  .  |.||| ||.|||.|. |.|.
eiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsstlvisyl

MKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
||   .   .|. .|. .|| | ||  |. ||. ||. |
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 167-300 3.3e-23 75.7 In-house 9-152 (154) alignment 
Range on Protein: 167-300
Range on HMM: 9-152/154.0
HLYLGSQKDVLNKDLMTQNGISYVLNA----SNSCPKP------DFICEsrFMRVPINDNYCEKLLPWLDKSIEFIDKAK--LSSCQVIVHCLAGISRSA
.||..|..  ||| .. .. |  .||     .|  ..        || |  .... . |.   ...  |||. ||||.|   .   .|.||. .|.||||
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiie..ylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsa

TIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
...|.|.|. . .|   |. ..|| |. |.||  || ||  .|. |
allisylmdklkislslalellkdsryiikPnqGflkqleifekel
0040439 (Phosphotyrosine protein) phosphatases II 180-299 3.2e-22 74.8 In-house 72-244 (249) alignment 
Range on Protein: 180-299
Range on HMM: 72-244/249.0
DLMTQNGISYVLNASNSCPKP------------------------------------------DFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKL
... ..||........ ...                                            .  . . . ... |    .. |...  ..||.... 
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

------SSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
      ... |.||| ||..|..|...||.|     |. |.. ..|.......|| . .|.... .|.|... 
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 181-299 7.7e-22 73.8 In-house 126-302 (307) alignment 
Range on Protein: 181-299
Range on HMM: 126-302/307.0
LMTQNGISYVLNASNSCPKPDFICESRF---------------------------MRVPINDN-----------------YCEKLLPWLDKSIEFIDKAK
.. ..|...... ...... . .|   .                           ..... |.                    .. |...  ..||....
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

L------SSCQVIVHCLAGISRSATIAIAYIMKTMG--------MSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
       ... |.||| ||..|..|...||.|....        .. ..|.......|| . .|.... .| |... 
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 164-300 8.5e-21 67.8 In-house 14-153 (157) alignment 
Range on Protein: 164-300
Range on HMM: 14-153/157.0
ILPH-LYLGSQKDVLNKDLMTQNGISYVLNASNSCPK-PDFICE-SRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAY
.||. ||||  |.  |. .     .  ..| |. . |  . . . .. ......|.   .||. |.. ..||.| | ..  |.|    ||||||...|||
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
.|    ..  .|| ..|. .. . || .|. || |.|..|
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0051082 (Phosphotyrosine protein) phosphatases II 160-296 2.8e-20 67.9 In-house 7-149 (151) alignment 
Range on Protein: 160-296
Range on HMM: 7-149/151.0
GLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKP-----DFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLS-SCQVIVHCLAGISRS
 .... ..||....    . .|. ..||....|  .  . .         . .....|| |.   .|  ..|  .||....    .  |.||| ||..|.
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATIAIAYIMKtMGMSSDDAYRFVKDRRP-SISPNFNFLGQLLEY
.|....|.|. .|.| ..|..... .|| .. ||  || ||...
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0038934 (Phosphotyrosine protein) phosphatases II 186-298 3.6e-20 67.9 In-house 58-174 (194) alignment 
Range on Protein: 186-298
Range on HMM: 58-174/194.0
GISYVLNASNSCPKPDFICES--RFMRVPINDNYCEKLLPWLDKSIEFIDK--AKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRP
|  . |. .. .  |. . ..  .... |. | ..   |  |.. ....|.  .. ... | ||| ||..|..|...||.....||| ..|.......||
glvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRp

SISPNFNFLGQLLEYER
.. || ..| .||.. .
gaipnqdyleallkryk
0040438 (Phosphotyrosine protein) phosphatases II 181-299 4.6e-20 67.6 In-house 105-274 (317) alignment 
Range on Protein: 181-299
Range on HMM: 105-274/317.0
LMTQNGISYVLNASNSCPKPDF--------------------------ICESRFMRVPINDN----------------YCEKLLPWLDKSIEFIDKAKLS
.. ..|......  ..... .                             .    .... |.                   .. |..|  ..|..... .
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----SCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERS
    .. |.||| ||..|..|...||.|     |..|.. ..|..... .|| . ...... .| .... 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0039614 (Phosphotyrosine protein) phosphatases II 182-300 7.9e-20 66.9 In-house 121-288 (297) alignment 
Range on Protein: 182-300
Range on HMM: 121-288/297.0
MTQNGISYVLNASNSCPKPDfICES------------------------------------------RFMRVPINDNYCEKLLPWLDKSIEFIDKAKL--
. ..|......  . ...    |..                                          .|  ... |. .  .|  |.. .|....|    
vweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-SSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
 ... |.||| ||..|..|...||.|     |. |.. ..|..... .|| . ...... .| .... |
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 168-301 1.1e-19 63.9 In-house 6-142 (145) alignment 
Range on Protein: 168-301
Range on HMM: 6-142/145.0
LYLGSQKDVLNKDLMTQNGISYVLN--ASNSCPKPDFICES-RFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKT
|| ||     .  .... ||| ..|  |...    .  .||   . .  .|     |   .|.  .|||| |     |.|||.||.||| |...|..|| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

MGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLK
 .|.  .| | |. .|    || .|| .||. |. ||
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0036941 (Phosphotyrosine protein) phosphatases II 184-300 1.9e-18 62.3 In-house 100-276 (297) alignment 
Range on Protein: 184-300
Range on HMM: 100-276/297.0
QNGISYVLNASNSCPKPDFICESRFMRV-------------------PINDNYCE---------------------------KLLPWLDKSIEFIDKAKL
..... ... ..  ..    |.. .                       ..|.|.                            .. .. .  ..||.... 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------SSCQVIVHCLAGISRSATIAIAYIM--------KTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
      |.  |.||| ||..||.|...|..|        |. |..  .|.......|| . ...... .| |..  |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0051429 (Phosphotyrosine protein) phosphatases II 163-299 3.3e-18 61.8 In-house 18-223 (272) alignment 
Range on Protein: 163-299
Range on HMM: 18-223/272.0
RILPHLYLGSQK----DVLNKDLMTQNGISYVLNASNSC----PK-PDFICESRFMRVPINDNYCEKLLPWL----------------------------
...|.... |.     .. . . . ..||.....  . .     | . ..   |....||.|.. .  | .                             
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------DKSIEFIDKAKLsSCQVIVHCLAGISRSATIAIAYIMKtMGMS--------------SDDAYRFVKDRRPSISPNFNFLG
                    .  .|...     .  |.||| ||..|..|.. ....  .|.|               ..|.. ....|| . ..  .. 
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLLEYERS
.|.|... 
flyealle
0043336 (Phosphotyrosine protein) phosphatases II 183-298 1.8e-17 59.2 In-house 154-274 (278) alignment 
Range on Protein: 183-298
Range on HMM: 154-274/278.0
TQNGISYVLNASN-SCPKPDFICESRFMRVPiNDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFV
 .. . ..|. .|  .... ...   .. .|  .. .| | . ||   ..... . |.  |.||| ||..|..|....|..     |. |.. ..|....
lddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

KDRRPSISPNFNFLGQLLEYER
. .||.. ...... .| |...
reqRpgavqtpsqyrflyeall
subfamily_PTPMT1_pd Subfamily PTPMT1 208-300 5.3e-17 56.8 In-house 76-168 (171) alignment 
Range on Protein: 208-300
Range on HMM: 76-168/171.0
FMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
...... |   .  |  | |..|||.| . .  .| ||| || .||||....|.||.  .|...| ...|..|. |  . . . .| |||..|
qlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_MSG5_pd Subfamily MSG5 225-300 3.1e-16 52.9 In-house 85-160 (165) alignment 
Range on Protein: 225-300
Range on HMM: 85-160/165.0
LDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
| .  . |  |.    ...|||  |.||||.. .|||||  ..|  |||  .| .   |||.. .. ||.|.|  |
lsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 197-294 1.5e-14 49.5 In-house 162-265 (273) alignment 
Range on Protein: 197-294
Range on HMM: 162-265/273.0
CPKPDFICESRFMRVPinDNYCEKLLPWLDKSIEFIDKAKL---SSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFN
.... ...   ..  |  |. .   |  | . ||...||     |.  |.||| ||..|..|.......     |. |.. ..|.......|| . ....
tgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

FLGQLL
.. .| 
qyrfly
0051299 (Phosphotyrosine protein) phosphatases II 189-289 3.3e-13 45.2 In-house 165-274 (288) alignment 
Range on Protein: 189-289
Range on HMM: 165-274/288.0
YVLNASN-----SCPKPDFICESRFMRVPiNDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKD
..|  .|      . .. ..    ..  | .... . . ..||   ..... . ... |.||| ||..|..|.......     |. |..  .|..... 
rtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlre

RRPSISPNFNF
.|| . .... 
qRpgmvqtpeq
Rhodanese Rhodanese-like domain 13-130 1.6e-11 36.7 Pfam-A 2-111 (113) alignment 
Range on Protein: 13-130
Range on HMM: 2-111/113.0
AKKLASLLrgGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLvkrrL----QQGKVTIAELiqpAARSQVEATEPQDVVVYDqSTRDASVLAADSFLSIL
||.|..||  . ......| ||. ||. .|.  .||.. . |         .  |  .||     ..|. .  . . ||||. .. ..|  || ..|  .
akelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl....yprrdlffkdklaee...leesgkkldkdktvvvyc.rsgnrsggaaalllali

LSKLdgCFDSVAILTGGFATFS
|..|   .. | .| |||  ..
lkel..gyknvyvLdGGfeawk
0050432 (Phosphotyrosine protein) phosphatases II 227-288 2e-11 39.2 In-house 218-286 (308) alignment 
Range on Protein: 227-288
Range on HMM: 218-286/308.0
KSIEFIDKAKLS--SCQVIVHCLAGISRSATIAIAYIM-----KTMGMSSDDAYRFVKDRRPSISPNFN
  ..|..... |  .. ..||| ||..|..|.......     |. |..  .|..... .||   ....
illdflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 227-287 2.4e-11 39.0 In-house 186-260 (284) alignment 
Range on Protein: 227-287
Range on HMM: 186-260/284.0
KSIEFIDKAK------LSSCQVIVHCLAGISRSATIAIAYIMKTM--------GMSSDDAYRFVKDRRPSISPNF
  .||.....       ... ..||| ||..|..|..........        |..  .|.......||    ..
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_DSP23_pd Subfamily DSP23 181-282 5.5e-11 37.3 In-house 26-127 (148) alignment 
Range on Protein: 181-282
Range on HMM: 26-127/148.0
LMTQNGISYVLNASNSCPKP-DFICESRFMRVPINDnYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDR
 . ..|. |..  .. .. . . . .  ..|. |.| |.   |  ... .. ...|.  .  | |||| |  |. |.   |..|  .... .|   |. .
ylldlgvrylvslteegrphveatpnltlvrlridd.yhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RPS
|| 
rpg
0048567 (Phosphotyrosine protein) phosphatases II 225-286 6.5e-10 33.6 In-house 60-124 (157) alignment 
Range on Protein: 225-286
Range on HMM: 60-124/157.0
LDKSIEFIDKAKLSSCQVIVHCLAGI---SRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPN
  |  .|..  .| .....||| ||    .|.||.. .|... .|.. ..|.....  ||.. | 
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf
PTPc_DSPc_SM00012 226-277 7.1e-07 24.7 In-house 20-80 (105) alignment 
Range on Protein: 226-277
Range on HMM: 20-80/105.0
DKSIEFIDKAKLSSC------QVIVHCLAGISRSATIAIAYIMKTMGMSS---DDAYRFVK
|. .|.... | .         |.||| ||..|..|.. ..|.  . ...   .| ...||
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivk
subfamily_PTPDC1_pd Subfamily PTPDC1 236-282 1.2e-06 23.1 In-house 111-157 (182) alignment 
Range on Protein: 236-282
Range on HMM: 111-157/182.0
KLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPS
 |.  .| ||| ||  |   .  .|.. .  .....| ..|...||.
alqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_PRL_pd Subfamily PRL 237-291 1.5e-06 22.4 In-house 88-140 (151) alignment 
Range on Protein: 237-291
Range on HMM: 88-140/151.0
LSSCQVIVHCLAGISRSAT-IAIAYImkTMGMSSDDAYRFVKDRRPSiSPNFNFLG
 ... | |||.||. |.   .|.| |    ||...|| .|....| . . | . | 
epkstvavhcvaGlGraPvlvalali..eaGmkyedavefirekrrg.ainskqlk
subfamily_CDC14_pd Subfamily CDC14 230-282 1.8e-06 22.0 In-house 254-306 (328) alignment 
Range on Protein: 230-282
Range on HMM: 254-306/328.0
EFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPS
.|.. |. .. ...||| ||. |  |.  .|.||. .... .|  ...  || 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPG
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 229-261 3.3e-06 21.5 In-house 181-213 (290) alignment 
Range on Protein: 229-261
Range on HMM: 181-213/290.0
IEFIDKAKLSSCQVIVHCLAGISRSATIAIAYI
.. |.| | |   |||||  ||||||..|   .
lsliqkvkasktpvivHcvdGiSrsAalaaiil
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 223-270 7e-06 20.2 In-house 192-243 (307) alignment 
Range on Protein: 223-270
Range on HMM: 192-243/307.0
PWLD-KSIEFIDKAKLSSCQVIVHCLAGISRSATI-AIAYIMKTM--GMSSD
| ..  .|....  .     |.||| ||. || || ||....  |  |.   
pqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinck
subfamily_RNGTT_pd Subfamily RNGTT 236-284 7.4e-06 19.8 In-house 110-159 (189) alignment 
Range on Protein: 236-284
Range on HMM: 110-159/189.0
KLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYR-FVKDRRPSIS
| ... ..|||  |  |.  ....|..... .| ..| . | | | | | 
knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiy