Gene PTP4A3 in Homo sapiens

Synonym: PRL-3, PRL-R, PRL3, PTP4A3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP037_AA protein Get Run
HsapP037_AA_6-159 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 9-157 1.1e-79 259.8 In-house 2-150 (151) alignment 
Range on Protein: 9-157
Range on HMM: 2-150/151.0
PVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGL
.||..||.||||||..||.|||..|||.|||....|||||||.|||...|||.||.|.|..|||||.|| .|||.||.|.|.||.|.|.|.|||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQR
|||||||||||||.|||||||..|||.|||||||||||..||||..|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0043147 (Phosphotyrosine protein) phosphatases II 8-166 5.4e-41 135.5 In-house 11-169 (172) alignment 
Range on Protein: 8-166
Range on HMM: 11-169/172.0
APVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAG
 .....|. .||..|. |.. ||. |.. ||..| |..|...| .||...||. ||..  .|..|. .|. ......|.... .... || .|.|||.||
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaG

LGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTH
.||...|||. |.. |...|.|....|.||.||. ...  .. .|  |..|..|| ...
vgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdslae
0038934 (Phosphotyrosine protein) phosphatases II 18-153 2.2e-37 124.0 In-house 19-170 (194) alignment 
Range on Protein: 18-153
Range on HMM: 19-170/194.0
RFLITHNPTNATLSTFIEDLKKYGATTVVRVC----------------EVTYDKTPLEKDGITVVDWPFDD-GAPPPGKVVEDWLSLVKAKFCEAPGSCV
||.... |.. .| ..||.|.... ...||..                | .||.. .|| ||.....|| | |..|. ... ..|.||. .. | || .|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRRGAINskQLTYLEKYR
||||.|||||...||| .||.  ||..|.||...|.||.|||.  .  ||| ..
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaip..nqdyleall
0049260 (Phosphotyrosine protein) phosphatases II 12-151 7.4e-37 121.7 In-house 4-144 (152) alignment 
Range on Protein: 12-151
Range on HMM: 4-144/152.0
VSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRA
. .....|..|. |.. ||. |.. ||..|.||.|...| .... . .. .|..  .|..|. .|.   . ..| |.  |... .| .|.|||.||.||.
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

PVLVALALIESGMKYEDAIQFIRQKRRGAINSKQ-LTYLEK
..|||. |.. |...|.|....|.|| ||. ... | .| .
gtlvaaylmllgvsleeavalvrekRpgavpnpgqlrflye
0040439 (Phosphotyrosine protein) phosphatases II 10-152 2.1e-32 108.1 In-house 47-241 (249) alignment 
Range on Protein: 10-152
Range on HMM: 47-241/249.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT---------------------------------------------YDKTPLEKDGIT
....|  .||..|  |.. |.. |.. |...| |..|.... .                                             ||.....  .| 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VVDWPfDDGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAI-NSKQLTYLEKY
..||| |.|.||  . . |.. .|.  . |. .|..|.||| ||.||.....|. |.      | |. .|.|....|..|.||. |  |. .| ..
ytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0041856 (Phosphotyrosine protein) phosphatases II 12-161 1.2e-31 105.1 In-house 29-174 (182) alignment 
Range on Protein: 12-161
Range on HMM: 29-174/182.0
VSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPgkvVEDWLSLVKAKFCeaPGSCVAVHCVAGLGRA
 |....||..|. |.. |.  |.. ||..| ||.|...|. |. . ||. ||.....|..|. .|.   ....|.....     .| .|.||| ||.||.
gslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRt

PVLVALALIE-SGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFK
..|||. |..  |. .|.|....|..| |.. . .  ... .   ..|..|
gtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0045098 (Phosphotyrosine protein) phosphatases II 14-160 2.1e-31 104.8 In-house 62-275 (278) alignment 
Range on Protein: 14-160
Range on HMM: 62-275/278.0
YkHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDK----------------------------------------------TPLEKDGITVVD
| ...|..|  |.. |.. |.. |...| |..|...|.....                                              . ||. |.|...
y.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

W-PFDDGAPPPGKVVEDWLSLVKA--KFCE-------------APGSCVAVHCVAGLGRAPVLVALALIES----GMKYEDAIQFIRQKRRG-AI-NSKQ
. |..|. .|.  ..  .|.|..   ....              .| .|.||| ||.||. .|||. |. .    |. ...|....|..|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LTYLEKYRPKQRLRF
. .|...  . .||.
yrflyefllelllrg
0036282 (Phosphotyrosine protein) phosphatases II 8-152 2.5e-30 100.9 In-house 8-165 (174) alignment 
Range on Protein: 8-152
Range on HMM: 8-165/174.0
APVEVSYKHMRFLITHNPTNatlstFIEDLKKYGATTVVRVCEVTYDK------------TPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEA
 |. .||   |....  |..     |.| ||..| ||||...|  ...            . ||. ||.....|..|. .|.  ........|.  . | 
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

PGSCVAVHCVAGLGRAPVLVALALIESGM--KYEDAIQFIRQKR----RGAINSKQLTYLEKY
|| .|.||| ||.||...|||. |.. |.  ...||....|..|    .. ..  |. .| ..
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0046846 (Phosphotyrosine protein) phosphatases II 18-154 5.1e-30 99.9 In-house 24-170 (176) alignment 
Range on Protein: 18-154
Range on HMM: 24-170/176.0
RFLITHNPTNATLSTFIEDLKKYGATTVVRVCEV--------TYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEapGSCVAVHCVAGLG
|...|. |.. || .|.| ||..| |.||...|         ...   ||| ||..  .|..|. .|. . ....| ...    |  | .|.|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealke..ggpvlVHCsaGig

RAPVLVALALIES--GMKYEDAIQFIRQKRR-GAI-NSKQLTYLEKYRP
|...|||. |.|.  |...|.|....|..|. ||. . .|. .|...  
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0045450 (Phosphotyrosine protein) phosphatases II 4-152 5.9e-30 100.5 In-house 94-299 (307) alignment 
Range on Protein: 4-152
Range on HMM: 94-299/307.0
MNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTP------------------------------------------LEKD
......... .. ..|..| .|.. |.  |.. |...| |..|...| .... .                                           .. 
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

GITVVDWPF----DDGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALALIESG---------MKYEDAIQFIRQKRRGAI-NSKQL
..||  ...    |.|.||  . . |.. .|.. . |  .|..|.||| ||.||.....|. |. ..         . ...|....|..| ||. |  |.
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

TYLEKY
 .| ..
rflyea
0039614 (Phosphotyrosine protein) phosphatases II 14-158 2.8e-29 97.9 In-house 97-290 (297) alignment 
Range on Protein: 14-158
Range on HMM: 97-290/297.0
YK-HMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYD----------------------KTPLEKDGIT-------------------VVDWPfD
..  ..|..|  |.. |.  |.. ....| |..|.... ...                      ..  ..||.|                   ...|| |
dlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.d

DGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAI-NSKQLTYLEKYRPKQRL
.|.||  ... ..| ||.  . |. .| .|.|||.||.||. ...|. |.      | |. ...|....|..|.||. .  |. .| ..  . ..
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0042113 (Phosphotyrosine protein) phosphatases II 10-152 3.2e-28 94.2 In-house 45-238 (245) alignment 
Range on Protein: 10-152
Range on HMM: 45-238/245.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT---------------------------------------------YDKTPLEKDGIT
| ...   .|..|  |.. |.  |.. |...| ||.|...| .                                             .|. ..|   . 
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VVDWPfDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAI-NSKQLTYLEKY
 ..|| |.|.|.  . ..|.|..|.    | ..  |.||| ||.||. ...|. |.      | |.  |.|....|..|.||. .  |. .| ..
ylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 11-149 1.2e-27 92.5 In-house 82-269 (278) alignment 
Range on Protein: 11-149
Range on HMM: 82-269/278.0
EVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT--------------------------------------------YDKTPLEKDGITVV
..  . ..|..|  |.. |.  |.. ....| ||.|...| .                                            .|. ...  ..  .
dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhyl

DWPfDDGAPPPGKVVEDWLSLVKAKFCeAPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAI-NSKQLTYL
.|| |.|.|.. . . |.|  |. ..   ....|.|||.||.||. ...|| |.      | |. .|.|....|..| ||. .  |. .|
gwp.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 26-155 3.1e-27 90.8 In-house 37-169 (178) alignment 
Range on Protein: 26-155
Range on HMM: 37-169/178.0
TnatlSTFIEDLKKYGATTVVRVCEVTY------DKTPLEKDGITVVDWPFDDGAPPP-GKVVEDWLSLVKAKFcEAPGSCVAVHCVAGLGRAPVLVALA
.    . ..| ||..| |..|...| ..      |.  .|. ||... .|..|. .|.  . ..... ....   . .|..|.||| ||.||...|||. 
p....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal.dekggpvlVHCsaGvgRsgtlvaay

LI-ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPK
|. . |. .|.||...|..|.. .|  || .|... ..
lmkklglsleeaielvrerRpivpnpgqlrqLyefelr
0050432 (Phosphotyrosine protein) phosphatases II 12-145 7.3e-26 86.6 In-house 101-286 (308) alignment 
Range on Protein: 12-145
Range on HMM: 101-286/308.0
VS--YKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDK--------------TPLEKDGITV------------------------------
.   .. ..|..|  |.. |.  |.  . ... ...|.... ....              ..|| ...||                              
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvt

----VDWPfDDGAPPPGKVVEDWLSLVKAKFceaPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAINSKQ
     .|| |.|.||  . . |.| ||. ..   ||. ..||| ||.||. ...|| |.      | |. ...|....|..| |......
hfhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0051082 (Phosphotyrosine protein) phosphatases II 19-150 1.1e-25 85.4 In-house 15-145 (151) alignment 
Range on Protein: 19-150
Range on HMM: 15-145/151.0
FLITHNPTNatlsTFIEDLKKYGATTVVRVCEVT---YDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLV
....  |..     |.| ||..| .|.| ... .   |.. .|.. ||.|...|..|  .|.  .  |..  .  .. . .. .|.||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLE
|| |.  |. .|.|....|.|| |.....|  ...
alylmllgvsleealeeyrlkrpgvvqpnqqflfq
0040438 (Phosphotyrosine protein) phosphatases II 10-152 1.4e-25 85.6 In-house 79-271 (317) alignment 
Range on Protein: 10-152
Range on HMM: 79-271/317.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT---------------------------------------------YDKTPLEKDGIT
|.. .. ..|..|  |.. |.  |.. ....| |..|...| .                                             .|.....   . 
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VVDWPfDDGAPPPGKVVEDWLSLVKAKFCeAPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAI-NSKQLTYLEKY
  .|| |.|.||  . . |.|..|....   ||..|.|||.||.||. ...|. |.      | |. .|.|....|..|.||. .  |. .| ..
ytgWp.dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 10-145 1.6e-25 85.5 In-house 70-259 (273) alignment 
Range on Protein: 10-145
Range on HMM: 70-259/273.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKT--------------PLEKDGITV------------------------------
|.. .. ..|..| .|.. |.  |.  .........|...|.....               .|. . .||                              
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

----VDWPfDDGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAINSKQ
     .|| |.|.||  . . ... ||. .. ..  .. |.|||.||.||. ...|| |.      | |. ...|....|..| |.. . .
hfhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0037934 (Phosphotyrosine protein) phosphatases II 18-152 1.3e-24 82.5 In-house 45-237 (243) alignment 
Range on Protein: 18-152
Range on HMM: 45-237/243.0
RFLITHNPTNATLST----FIEDLKKYGATTVVRVCEVT------------------------------------------YDKTPLEKDGITVVDWPFD
|. .|  |.. |.      |.. |...| |..| ..| .                                          .| ..|.. .| .  .|. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGAPPP-GKVVEDWLSLVKAKFCE-------APGSCVAVHCVAGLGRAPVLVALALIES--GMKYEDAIQFIRQKRRG-AI-NSKQLTYLEKY
|. .|.  . . |.|. |..   |        .|. |.|||.||.||. .|.|. |. .  |. .|.|....|..| | |. .  |. .| ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0051299 (Phosphotyrosine protein) phosphatases II 10-145 1.8e-24 82.2 In-house 85-273 (288) alignment 
Range on Protein: 10-145
Range on HMM: 85-273/288.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT-------------------------------------------------YDKTPLEK
... .. ..|..|  |.. |.. |   . ... ...|......                                                 .|..... 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

DGITVVDWPfDDGAPPPGKVVEDWLSLVKAKFCeAPGSCVAVHCVAGLGRAPVLVALALI------ESGMKYEDAIQFIRQKRRGAINSKQ
  . . .|| |.|.|.  . . |.| ||. ..  ..|..|.||| ||.||. ...|| |.      | |. ...|....|..| |.... .
thfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0049772 (Phosphotyrosine protein) phosphatases II 17-154 5.3e-24 80.9 In-house 84-275 (314) alignment 
Range on Protein: 17-154
Range on HMM: 84-275/314.0
MRFLITHNPTNATLSTF--------------------------------------------------------------IEDLKkygattvvrvcEVTYD
..|..| .|.. |.  |                                                              .|.||           |..||
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........eelyd

KTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKfceAPGSCVAVHCVAGLGRAP--VLVALALIESGMKYEDAIQFIRQKRR-----GAINSKQLt
.  .|. ||.....|..|| .|. . ....| ....     .|..|.||| || ||..  |..|. ..  |. .|.|....|.||      |.|.. .. 
pelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq.

YLEKYRP
|..... 
yefilea
PTEN_1 31-154 2.7e-23 77.8 In-house 57-190 (196) alignment 
Range on Protein: 31-154
Range on HMM: 57-190/196.0
STFIEDLKKYGATTVVRVCE------VTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAP-GSCVAVHCVAGLGRAPVLVALALIESG
. . ..||. |.|.||...|      ..||..  .| |... . |..|  .|.   . |..  ..    ..| | .|.||| |||||  ..||  |...|
aadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykg

-MKYEDAIQFIRQKR-RGAIN-SKQLTYLEKYRP
 . ...|....|.|| .||.| ..|  .|| .. 
kltadeAlelvrekRppgapnspsqerlleyfae
0046845 (Phosphotyrosine protein) phosphatases II 12-145 8.2e-23 76.6 In-house 72-261 (284) alignment 
Range on Protein: 12-145
Range on HMM: 72-261/284.0
VSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVT-----------------------------------------------YDKTPLEKDGIT
..|....|..|  |.. |.  |   . .......| ..| .                                               |.. ...   . 
ltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

VVDWPfDDGAPPPGKVVEDWLSLVKAKFCE-APGSCVAVHCVAGLGRAPVLVALALIES---------GMKYEDAIQFIRQKRRGAINSKQ
. .|| |.|.||  . . ..| ||.  . .  .|. ..||| ||.||. ...|| |. .         |. ...|....|..| |.... .
ytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0048179 (Phosphotyrosine protein) phosphatases II 34-153 1.4e-22 75.4 In-house 22-141 (144) alignment 
Range on Protein: 34-153
Range on HMM: 22-141/144.0
IEDLKKYGATTVVRVCEvTYDKTPLEKDGITVVDWPFDDGAPPPG-KVVEDWLSLVKAKFCeaPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQ
.| |||.| |||....| .|... ||. ||... .|..|  .|.  . ....| ....     .| .|.||| ||.||...|||. |. . |. .|.|..
lellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIRQKRRGAI-NSKQLTYLEKYR
..|..| ||. |  || .|..|.
lvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 34-153 2.7e-22 74.4 In-house 22-139 (145) alignment 
Range on Protein: 34-153
Range on HMM: 22-139/145.0
IEDLKKYGATTVVRVcevTYDKTPLEKDGITVVDWPFDDGAPPPG-KVVEDWLSLVKAkfCEAPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAIQ
.| ||..| |||...   |.... ||. ||... .|..|  .|.  . ....| ....  . . | .|.||| ||.||...|||. |. . |. .|.|..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefiee..alkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIRQKRRGAI-NSKQLTYLEKYR
..|..|.||. |  || .|... 
lvrsqrpgavpnpgqlrflyefe
0036941 (Phosphotyrosine protein) phosphatases II 10-145 2.4e-21 71.8 In-house 71-264 (297) alignment 
Range on Protein: 10-145
Range on HMM: 71-264/297.0
VEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKT-------PLE---------------------KDGITV----------------
|.. .  ..|..|. |.. |.  |   . ... |..| ..|.. .         |||                     .|..|.                
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

-----VDWPfDDGAPPPGKVVEDWLSLVKAKFCEA-PGSCVAVHCVAGLGRAPVLVALAL---------IESGMKYEDAIQFIRQKRRGAINSKQ
      .|| |.|.|.  . . |.. ||. .  .. .|. | |||.||.||. ...|. |         .| |. . .|....|..| ||. . .
thfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle
subfamily_CDC14_pd Subfamily CDC14 31-152 2.6e-20 67.5 In-house 202-319 (328) alignment 
Range on Protein: 31-152
Range on HMM: 202-319/328.0
STFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKfceapGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDA
 ...|  .|.. |||||. .  ||..  .. |.  .|  | ||. |. ..|. .|....          .|||| |||||.  |.|  |..  ..  ..|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

IQFIRQKRRGAINSKQLTYLEKY
| ..|  | | . ..| ..||. 
iawlricrPGsvigpqqkfleek
0051429 (Phosphotyrosine protein) phosphatases II 18-150 2.8e-19 65.3 In-house 23-218 (272) alignment 
Range on Protein: 18-150
Range on HMM: 23-218/272.0
RFLITHNPTNATLSTFIEDlKKYGATTVVRVCEVT---YDKTPLEKDGITVVDWPFDDGAPPPG------------------------------------
|.. . .|...|   |    |..| .|.| .....   ..|....  ||... .|. | ..|.                                     
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------KVVEDWLSLVKAkfceapGSCVAVHCVAGLGRAPVLVALALIESGMK--------------YEDAIQFIRQKRRGAINSK-QLT
                . . ..|.|. .      |  | ||| || .|  ..||| |.  |.               .|.|.. .|..|.||. .  |. 
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

YLE
.| 
fly
subfamily_PTPDC1_pd Subfamily PTPDC1 51-149 6.3e-14 46.8 In-house 71-168 (182) alignment 
Range on Protein: 51-149
Range on HMM: 71-168/182.0
VTYDKTPLEKDGITVVDWPFDDGAPPPgkvVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRRGAINSKQ-LTY
 .||.  | . ||.|  ....|   ..   .|  | .||          ||||| |||||. ||.|  |.  . .. |.||...|.||  .|.... .  
fsYdlealmeqgiyvynfgwkDygvas...leriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvel

L
.
v
0048567 (Phosphotyrosine protein) phosphatases II 40-151 4.1e-13 44.0 In-house 15-132 (157) alignment 
Range on Protein: 40-151
Range on HMM: 15-132/157.0
YGATTVVRVCEVTYDKTPL-EKDGITVVDWPFDDGaPPPGKVVEDWLSLVKAKF--CEAPGSCVAVHCVAGL---GRAPVLVAL-ALIESGMKYEDAIQF
. .....|. . .|.  ..   ||.  .|. ||.| |..  .. ..  ... ..  .|  |  .|||| |||   ||. .|... ...  |.  |.||..
lyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiap

IRQKRRGAINSKQLTYLEK
.|. | | .   . .||. 
lrivrpgsvpfrdasylls
PTPc_DSPc_SM00012 66-145 3.8e-11 38.5 In-house 8-94 (105) alignment 
Range on Protein: 66-145
Range on HMM: 8-94/105.0
VDWPFDdGAPPPGKVVEDWLSLVKAKFCEAP-GSCVAVHCVAGLGRAPVLVALALIESGMKYE-------DAIQFIRQKRRGAINSKQ
 .||   |.| ... . ..|  || .  ..  .. | ||| || ||. ..|||... . ...|       . .. .|..|.|......
tgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
PTPc_motif_SM00404 37-143 1.5e-10 36.1 In-house 23-126 (140) alignment 
Range on Protein: 37-143
Range on HMM: 23-126/140.0
LKKYGATTVVRVCEVTYDKtpLEKDGITVVDWPFDD-GAPPPGKVVEDWLSLVKAkfCEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIR
|||.| |.|. | |.   .   |. |....  | || .  .  |  .  |. ...  .|. |  | ||| ||. |   |..  |..  ......|..|..
lkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfien..aekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvk

QKRrGAINS
..|  .|. 
erR.piisp
subfamily_DSP23_pd Subfamily DSP23 61-143 1.7e-10 35.7 In-house 50-131 (148) alignment 
Range on Protein: 61-143
Range on HMM: 50-131/148.0
DGITVVDWPFDDGAPPPGKVVEDWLSLVKAkfCEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRRGAINS
 ..|.|    ||  ||  . |.... .|.    |. .  |.|||. | ||.  ..|  |. | ..   .||  .|..| |....
pnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet
subfamily_PTEN_pd Subfamily PTEN 40-138 2e-10 36.0 In-house 59-157 (184) alignment 
Range on Protein: 40-138
Range on HMM: 59-157/184.0
YGATTVVRV-CEVTYDKTPLekdGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMK--YEDAIQFIRQK
 .   .  .  | .||.. .      |  .||||  ||| ...|. .. ... . | .   |.||| || ||. ||..  |..|..    |.|...  ..
kdhykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea

RR
| 
Rt
Y_phosphatase Protein-tyrosine phosphatase 42-147 3.1e-10 35.2 Pfam-A 114-227 (235) alignment 
Range on Protein: 42-147
Range on HMM: 114-227/235.0
ATTVVRVCEVTYDKTPL---EKDGITVVDWPfDDGAPppgKVVEDWLSLVKA---KFcEAPGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDA
. ...|..|.. .|..    |   . . .|| | |.|   . ... |.|...   .  ||  . | ||| || ||. ..||| .. . ..        ..
keytlrklelkkkkeesekrevkqlhytnWp.dhgvp...espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi

IQFIRQKRRGAINS-KQLT
.. .|..|.|...| .|. 
vkelRkqRpgmvqsleqYi
Y_phosphatase Protein-tyrosine phosphatase 42-147 3.1e-10 35.2 In-house 114-227 (235) alignment 
Range on Protein: 42-147
Range on HMM: 114-227/235.0
ATTVVRVCEVTYDKTPL---EKDGITVVDWPfDDGAPppgKVVEDWLSLVKA---KFcEAPGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDA
. ...|..|.. .|..    |   . . .|| | |.|   . ... |.|...   .  ||  . | ||| || ||. ..||| .. . ..        ..
keytlrklelkkkkeesekrevkqlhytnWp.dhgvp...espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi

IQFIRQKRRGAINS-KQLT
.. .|..|.|...| .|. 
vkelRkqRpgmvqsleqYi
DSPc Dual specificity phosphatase, catalytic domain 60-143 6.7e-10 33.9 Pfam-A 37-119 (133) alignment 
Range on Protein: 60-143
Range on HMM: 37-119/133.0
KDGITVVDWPFDDgapPPGKVVEDWLSLVKA--KFCEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRrGAINS
|  |. .. | .|      . ....|. ...  . .|. |  |.||| ||. | . |..  |..  ......|..|....| ..|. 
kseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skisp
DSPc Dual specificity phosphatase, catalytic domain 60-143 6.7e-10 33.9 In-house 37-119 (133) alignment 
Range on Protein: 60-143
Range on HMM: 37-119/133.0
KDGITVVDWPFDDgapPPGKVVEDWLSLVKA--KFCEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRrGAINS
|  |. .. | .|      . ....|. ...  . .|. |  |.||| ||. | . |..  |..  ......|..|....| ..|. 
kseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skisp
subfamily_CDKN3_pd Subfamily CDKN3 59-156 2e-09 31.3 In-house 96-195 (202) alignment 
Range on Protein: 59-156
Range on HMM: 96-195/202.0
EKDGITVVDWPFDDGAPPPGKVVEDWLSLVkaKFCEAPGSCVAVHCVAGLGRAPVLVAL--ALIESGMKYEDAIQFIRQKR-RGAINS-KQLTYLEKYRP
.. |..|  .|. ||  |      . |  .  . .   .    |||  ||||. ...|    ...  ....|||. .|. .  .||.. ||  ||...| 
qqaglivhhypiadglvpdiasclkileel..rinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrd

KQ
|.
kl
subfamily_PTPMT1_pd Subfamily PTPMT1 60-154 4.2e-09 31.1 In-house 71-166 (171) alignment 
Range on Protein: 60-154
Range on HMM: 71-166/171.0
KDGITVVDWPFDDGA-PPPGKVVEDWLSLVKAKfcEAPGSCVAVHCVAGLGRAPVLVALALI-ESGMKYEDAIQFIRQKRRG-AINSKQLTYLEKYRP
| |.. .  .  | .  |  . .|. . ...       |..| ||| || ||.  |||  |. .. .. |.|......||.   ...||.. |..|. 
klgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 28-149 9.2e-09 29.2 In-house 159-280 (302) alignment 
Range on Protein: 28-149
Range on HMM: 159-280/302.0
ATLSTFIeDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPfDDGAPppgkvVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALAL-I-----E
  |. |  | |..   ||    | . .|..   | ..   || | |||      |   .|   ||||.    | ||| ||.||.  |||.   |     .
tdleeft.dkksfklytveiknekkkkkvkktvdilafsawp.dhGap.....keaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskk

SGMKYEDAIQFIRQKRRGAINS-KQLTYL
   .  . .. .|| | ||... .||.||
kvtdllsivlpvrqcryGavqdeqqliyl
subfamily_RNGTT_pd Subfamily RNGTT 50-145 1.3e-08 28.7 In-house 65-162 (189) alignment 
Range on Protein: 50-145
Range on HMM: 65-162/189.0
EVTYDKTPLEKDGITVVDWPFD-DGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAIQFIRQKRRGAINSKQ
.  |||  ||| ||. |       |. |    |. . .||.  |.. | . ..|||  |  |.  |..  |.|   .. |.|..  .. |   |  ..
sryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyked
subfamily_DSP15_pd Subfamily DSP15 93-141 7.6e-08 26.6 In-house 74-123 (151) alignment 
Range on Protein: 93-141
Range on HMM: 74-123/151.0
CEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRRGAI
|   .  | |||.||. |.  ||.. |.    ....||...|...|  | 
cRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvan
subfamily_DSP3_pd Subfamily DSP3 95-151 1.3e-07 25.4 In-house 95-152 (162) alignment 
Range on Protein: 95-151
Range on HMM: 95-152/162.0
APGSCVAVHCVAGLGRAPVL-VALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEK
 . . | ||||.|. |...| .|  .|   |.  .||. .|.||.   |.  |  | .
qkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLae
subfamily_DSP11_pd Subfamily DSP11 76-144 6.1e-07 23.5 In-house 93-164 (178) alignment 
Range on Protein: 76-144
Range on HMM: 93-164/178.0
PPGKVVEDWLSLVKAKF--CEAPGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRRGAINSK
|  ..|... . ||     ..  .. ..|||  |. |.  |.   ||.  |.. ||||.   . |  ... .
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslere
subfamily_PTPN13_pd Subfamily PTPN13 64-145 1e-06 23.2 In-house 172-256 (273) alignment 
Range on Protein: 64-145
Range on HMM: 172-256/273.0
TVVDWPfDDGAPPPGKVVEDWLSLVKaKFCEaPGSCVAVHCVAGLGRAPVLVALA----LIE--SGMKYEDAIQFIRQKRRGAINSKQ
  |.|| | | |   . .   .. |. .. .   . ..||| ||.||. .|...     |||    .. .. .. .|..|.| . .|.
nfvkwP.dhgvPssaaellqfvaevr.rlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd
subfamily_DSP1_pd Subfamily DSP1 95-138 1.5e-06 22.4 In-house 93-137 (163) alignment 
Range on Protein: 95-138
Range on HMM: 93-137/163.0
APGSCVAVHCVAGLGRAPVLVALALIE-SGMKYEDAIQFIRQKRR
. .  | .|| ||. |.  |. . |.. . ...|.| .|..|.| 
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs
subfamily_DSP8_pd Subfamily DSP8 94-150 1.7e-06 21.7 In-house 90-145 (159) alignment 
Range on Protein: 94-150
Range on HMM: 90-145/159.0
EAPGSCVAVHCVAGLGRAPV-LVALALIESGMKYEDAIQFIRQKRrgAINSKQLTYLE
 .  ..| ||. ||  |..   .|  . .  |....| .|...||  .  |..| .|.
ksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnlnflg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 66-134 2e-06 22.2 In-house 185-260 (297) alignment 
Range on Protein: 66-134
Range on HMM: 185-260/297.0
VDWPFDDGAP-PPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQF------IR
|.|| ..       . . ...| |. .| .   . . |||.||.||. ||...  . . .| |....       .|
veWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklr
subfamily_STYX_pd Subfamily STYX 93-144 2.4e-06 20.7 In-house 92-143 (166) alignment 
Range on Protein: 93-144
Range on HMM: 92-143/166.0
CEAPGSCVAVHCVAGLGRAPVLVALALIES-GMKYEDAIQFIRQKRrGAINSK
.   |  | ||  ||. |.  ||   ..|. |.|| .| ......|   ||..
slqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerr.fcinpn
subfamily_DSP10_pd Subfamily DSP10 97-138 2.8e-06 21.3 In-house 92-134 (159) alignment 
Range on Protein: 97-138
Range on HMM: 92-134/159.0
GSCVAVHCVAGLGRA-PVLVALALIESGMKYEDAIQFIRQKRR
|| | ||| ||. |.  | .|  . . ... .|| .|...|| 
gsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
subfamily_Slingshot_pd Subfamily Slingshot 95-140 4.1e-06 20.3 In-house 94-140 (169) alignment 
Range on Protein: 95-140
Range on HMM: 94-140/169.0
APGSCVAVHCVAGLGR-APVLVALALIESGMKYEDAIQFIRQKRRGA
. || | |||  |. | | ...| |. | |...|.|.......|. .
kkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvi
subfamily_PTPRB_pd Subfamily PTPRB 62-132 4.5e-06 20.9 In-house 183-253 (293) alignment 
Range on Protein: 62-132
Range on HMM: 183-253/293.0
GITVVDWPfDDGAPPPGKVVEDWLSLVKAKF-CEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQF
    . || | | |   | . |..  |. .   .|  . . ||| ||.||. ...||  . . .. || .. 
qyhftsWp.dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi
subfamily_DSP19_pd Subfamily DSP19 98-140 4.9e-06 21.0 In-house 90-133 (152) alignment 
Range on Protein: 98-140
Range on HMM: 90-133/152.0
SCVAVHCVAGLGRAP-VLVALALIESGMKYEDAIQFIRQKRRGA
 .| ||| ||  |.. | .|  . .  ...|.|.. .|..|. .
gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 18-131 6.7e-06 19.7 In-house 89-206 (392) alignment 
Range on Protein: 18-131
Range on HMM: 89-206/392.0
RFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVV---DWPfDDGAPPPGKVVEDWLSLVKAKFCEAPgSCVAVHCVAGLGRAPVL
 .. .  |  |.|. | . . .  .||.. | ..       ..  ..     .|| |.. |     .  ..  |||.| .     . .|| ||.||. |.
ayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewP.dkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvv

VALALIESGMKY---EDAIQ
...  . .  |     | ..
isidsvvahakktrmvdvfn
DSPc_SM00195 42-144 8.8e-06 20.6 In-house 140-248 (263) alignment 
Range on Protein: 42-144
Range on HMM: 140-248/263.0
ATTVVRVCEVTYDK--TPLEKDGITVVDWPFDdGAPPPGKVVEDWLSLVKAKFCEApGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDAIQFI
. ...|. |.|...  .. .   . . .||   |.|   | | . |. || .  .   . . ||| ||.||. ..|.. .| | ..       .. .. .
deiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkel

RQKRRGAINSK
|..| |.....
RkqRpgmvqtl
PTPc_SM00194 42-144 8.8e-06 20.6 In-house 140-248 (263) alignment 
Range on Protein: 42-144
Range on HMM: 140-248/263.0
ATTVVRVCEVTYDK--TPLEKDGITVVDWPFDdGAPPPGKVVEDWLSLVKAKFCEApGSCVAVHCVAGLGRAPVLVALALIESGMKY------EDAIQFI
. ...|. |.|...  .. .   . . .||   |.|   | | . |. || .  .   . . ||| ||.||. ..|.. .| | ..       .. .. .
deiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkel

RQKRRGAINSK
|..| |.....
RkqRpgmvqtl