Gene PTPMT1 in Homo sapiens

Synonym: DUSP23, MOSP, PLIP, PNAS-129, PTPMT1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP039_AA protein Get Run
HsapP039_AA_35-188 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 16-187 7.1e-73 238.6 In-house 1-169 (171) alignment 
Range on Protein: 16-187
Range on HMM: 1-169/171.0
FYPTLLYTLFrgkVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGV
|||||||...   | ....|.||.||| ||.|||||.|||...|...|||..|...|||||...|.||..|||.||||||.|.|||.|. |.|..|.|||
fyPtllynvl...vekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgv

QFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
.|  |..|.|..|||||||||.||||.||.||.. .|.|||||..|..|.|..|...  |...|.|......
efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0044763 (Phosphotyrosine protein) phosphatases II 21-186 3.2e-33 110.2 In-house 6-170 (178) alignment 
Range on Protein: 21-186
Range on HMM: 6-170/178.0
LYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLrSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK
.. |.    . |.   ....|.| ..||.||  .  ..|....... .....||.|  || .  . ... |.. |.. ..|..  . |. ... |.|  .
rvllsnleglersdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefiee

YQ-SLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSyIHIRPGQLDVLKEFHKQI
.. . | .|.|||.||..||.|.|||||. ....|.|||.. . . |. | ..||||  |.||....
aldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 34-186 4.7e-33 109.8 In-house 8-172 (176) alignment 
Range on Protein: 34-186
Range on HMM: 8-172/176.0
HRDWYHRIDPTVLLGALP----------LRSLTRqLVQDENVRGVITMNEEYETRFL--CNSSQEWKRLGVEQLRLSTVDMtGIPTLDNLQKGVQFALKY
.. ....|.. ..||..|          | .  . ........ |....||.|. .|  .|  .|...||.. |.| ..|. |.|.|. |.. ..|  ..
ldldldyinanlilgsrpiatqgplprtladfle.mlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDh.gvpdlelllellefirea

QSLGQCVYVHCKAGRSRSATMVAAYLIQV-HKWSPEEAVRAIAKIRS-YIHIRPGQLDVLKEFHKQI
.. |..|.|||.||..|..|.|||||..  . .|.|||.. . ..|. ..   |.|.  |.||....
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
PTEN_1 12-187 2e-31 104.4 In-house 10-192 (196) alignment 
Range on Protein: 12-187
Range on HMM: 10-192/196.0
ARVLFYPTLLYTLFRGKVPGRAHRDWYHR-----IDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETrfLCN--SSQEWKRLGVEQLRLSTVDMTG
.. |..||.|..|..      |. ... |     ||.....| |.. .  ..  . .....|....||.|.   ..  . .|... |||.|...  | . 
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhga

IPTLDNLQKGVQFALKYQSL--GQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
 .    .   ..|.  ..|.  | .|.||||||..||.|.|||||.. .|....||.. ... |. ........  |.|. ... 
pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0038934 (Phosphotyrosine protein) phosphatases II 39-188 8.2e-30 99.3 In-house 14-178 (194) alignment 
Range on Protein: 39-188
Range on HMM: 14-178/194.0
HRIDPTVLLGALPLRSLTRQLVQDEN-----------------VRGVITMNEEyeTRFLcnSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKY
..| . ..  ..|| .  .. .....                 .. ||.....  .|.   . .|....|.| |.| ..|   .|.|..|.. .... ..
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnt..eryY..dpeefekagieylklpfpddgtvPsleillrfldlvdef

--QSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITA
  .. |..|.||||||..|..|.||||||.....|.|||.. .. .|  . .....|..| ...|..  
lnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0048179 (Phosphotyrosine protein) phosphatases II 36-185 8.1e-29 95.6 In-house 2-143 (144) alignment 
Range on Protein: 36-185
Range on HMM: 2-143/144.0
DWYHRIDPTVLLGALPlRSLTRQLVQDENVRGVITMNEEYETRFLCNSsqewkrlGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAG
.....|.| . || ||  .|  .| .. ... ||...||||  || .        |.. |.|.. |.   . |. |.. ..|  .... | .|.|||.||
snpseilpglylgslp.taldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaG

RSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQ
..|..|.|||||. ....|.|||.. . ..|..... ||||  |.|..|.
vgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 36-185 1e-28 95.2 In-house 2-141 (145) alignment 
Range on Protein: 36-185
Range on HMM: 2-141/145.0
DWYHRIDPTVLLGALPlRSLTRQLVQDENVRGVITMneeyetrflCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAG
.|...|.| . || ||   | ..| .| ... |...         ..  . ..|||.. |.|.. |..  . |. |.. ..|  .... | .|.|||.||
ywpseilpglylgslp.taldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaG

RSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQ
..|..|.|||||.  ...|.|||.. . . |... ..||||  |.||...
vgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0036282 (Phosphotyrosine protein) phosphatases II 39-185 1.4e-28 95.2 In-house 13-168 (174) alignment 
Range on Protein: 39-185
Range on HMM: 13-168/174.0
HRIDPTVLLGALPLRslTRQLVQDENVRGVITMNEEYETR------FLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDnLQKGVQFALKYQSL--GQCVYV
..| | ...|. ||.    ......... |....||.|        .    .. ..|||.. |.| ..|..  ..   |.. |.|. ...|   | .|.|
syitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCKAGRSRSATMVAAYLIQVHKW-SPEEAVRAIAKIR---SYIHIRPGQLDVLKEFHKQ
||.||..|..|.|||||. .... |...|.. ....|   ... ..|.|.  | .|.|.
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0049772 (Phosphotyrosine protein) phosphatases II 79-186 9.1e-27 90.0 In-house 168-273 (314) alignment 
Range on Protein: 79-186
Range on HMM: 168-273/314.0
FLCNSSQEWKRLGVEQLRLSTVDmTGIPTLDNLQKGVQFALKYqSLGQCVYVHCKAGRSRSAT-MVAAYLIQVHKWSPEEAVRAIAKIRSyIHIRPGQLD
  ... . ..|||.. ||. . |  . |.|. ... ..| ... . | .|.||||||..|..| .|||||.  ...|.|||.. . ..|. |...||.. 
eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfie

VLKEFHKQI
 |... .. 
qleqyefil
0043147 (Phosphotyrosine protein) phosphatases II 56-186 6.3e-26 86.5 In-house 36-160 (172) alignment 
Range on Protein: 56-186
Range on HMM: 36-160/172.0
TRQLVQDENVRGVITMNEEyetrflCNSSQEWKRLGVEQLRLSTVDMTGIpTLDNLQKGVQFALK--YQSLGQCVYVHCKAGRSRSATMVAAYLIQvHKW
 .......... .....|.      ..  .  .|||.. |.|.  |..   .|. |.. ..|  .   .| | .|.|||.|| .|..|.|||||.. ...
fwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lgl

SPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQI
|.||||. . . |...   |.|.  |..|.|..
sleeavalvrekRpgavqnpsqyrflyyfekll
0045098 (Phosphotyrosine protein) phosphatases II 15-185 1.3e-25 85.8 In-house 19-270 (278) alignment 
Range on Protein: 15-185
Range on HMM: 19-270/278.0
LFYPtllYTLFRGKVPGRAHRDWYHRI--------------------DPTVLLGALPLRSLT---RQLVQDENVRGVITMNEEYET--------------
|..|   .. . .  .| .....|. |                    ... .. . || | .    ......... .....|..|               
lgip...seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

--------------------------RFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLD---NLQKGVQFALKYQS--------------LGQCVYVHCKA
                          . |..  .... .||..| . ...  |.|.|.    ... ..| .....               | .|.|||.|
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GRSRSATMVAAYLIQVH---KWSPEEAVRAIAKIRSY-IHIRPGQLDVLKEFHKQ
| .|..|.|||||.  .   .....|||. . . | . .   ..|.  | ||. .
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0037934 (Phosphotyrosine protein) phosphatases II 22-185 1.5e-25 85.6 In-house 22-240 (243) alignment 
Range on Protein: 22-185
Range on HMM: 22-240/243.0
YTLFRGKVPGrahRD----WYHRIDPTVLLGALPLRSLTRQ-------LVQDENVRGVITMNEEYET---------------------------------
|   | |..|    |     .... |.. .. .|| . . .       ........ .....|..|                                  
ydhsrvkleg...sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytv

RFLCNSS---QEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSL---------GQCVYVHCKAGRSRSATMVAAYLIQVH-KWSPEEAVRAIAK
| |. .    ....||..  ..|.  |..  .. ..|.. .... ....          |  |.|||.||..|..|..||||.  . ....||||. . .
rtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllre

IRSY-IHIRPGQLDVLKEFHKQ
 |.. .   |.|.  | |....
qRpgkavqtpsqyrflyealle
0041856 (Phosphotyrosine protein) phosphatases II 34-183 5.9e-25 83.3 In-house 15-167 (182) alignment 
Range on Protein: 34-183
Range on HMM: 15-167/182.0
HRDWYHRIDPTVLLGALPLR-------------SLTRQLVQDENVRGVITMNEEYETRflcnssQEWKRLGVEQLRLSTVDMTGIPtldnLQKGVQFALK
|  ....| . ..||.|| .                 ......... .....||.         ....|||.. |.|.  |..  .    |.. ..|  .
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp......ellerlgiqylylpwpDhgvpd....ldelldfiee

YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFH
 .. | .|.|||.||..|..|.|||||. ....|.||||. . . |. . |.| |. .|  . 
vleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlal
0042113 (Phosphotyrosine protein) phosphatases II 39-184 7.4e-25 83.2 In-house 48-240 (245) alignment 
Range on Protein: 39-184
Range on HMM: 48-240/245.0
HRIDPTVLLGALPLRSlTRQ----LVQDENVRGVITMNEEYE-----------------------------------TRFLCNSS-QEWKRLGVEQLRLS
.|| |...... ||.. | .    ........ .....|| |                                   .| |. .  .... . | ...  
yritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

TVDMTGIPT-LDNLQKGVQFALKYQS--LGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK
 ..  |.|. |. |.. ..|..|...   .  |.|||.||..|..|..||||.       ...|.||||. . . |. .   |.|.  | |...
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0049260 (Phosphotyrosine protein) phosphatases II 57-185 2.3e-24 81.2 In-house 26-148 (152) alignment 
Range on Protein: 57-185
Range on HMM: 26-148/152.0
RQLVQDENVRGVITMNEEYEtRFLCNSSQEWkrlgvEQLRLSTVDMTGIPTLDNLQKGVQFALK-YQSLGQCVYVHCKAGRSRSATMVAAYLIQvHKWSP
 ..... ... .....|..| .  .   | .     . |.| . |..  .  . |.  ..|  | ... | .|.|||.|| .|..|.|||||.  ...|.
wrmlkelgittivmltelle.lgklkceqyi.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsl

EEAVRAIAKIRSYIHIRPGQLDVLKEFHKQ
||||. . . |... . ||||  |.||.|.
eeavalvrekRpgavpnpgqlrflyefekl
0051082 (Phosphotyrosine protein) phosphatases II 37-175 4.1e-24 80.3 In-house 7-141 (151) alignment 
Range on Protein: 37-175
Range on HMM: 7-141/151.0
WYHRIDPTVLLGALPLRsLTRQLVQDENVRGVITMNEEYETRflcNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSL-GQCVYVHCKAG
....... ..... ||     .|....... ......|.|.    .  . ...||.| |..  .|..  .. ....  ..|  ....  ...|.|||.||
nfsyvtgglyrsggpla.dflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

RSRSATMVAAYLIQvHKWSPEEAVRAIAKIRSYIHIRPGQ
..|..|.||.||.  ...|.|||.. . ..| .. . . |
kgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqq
0040439 (Phosphotyrosine protein) phosphatases II 40-184 9.2e-22 73.3 In-house 51-243 (249) alignment 
Range on Protein: 40-184
Range on HMM: 51-243/249.0
RIDPTVLLGALPLRSLT---RQLVQDENVRGVITMNEEYET-----------------------------------RFLCNSS-QEWKRLGVEQLRLSTV
.| .....   || . .   .......... ....... |                                    | |. .  .. . . | ...    
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

DMTGIP-TLDNLQKGVQFALKYQS---LGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK
  .|.| ... | . .. ..|...    | .|.|||.|| .|..|..||||.       .....||||. . . |...   |.|.  | |. .
pdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 36-184 3.1e-21 71.6 In-house 94-286 (297) alignment 
Range on Protein: 36-184
Range on HMM: 94-286/297.0
DWYHRIDPTVLLGALPLRSLT---RQLVQDENVRGVITMNEEYETRFlcNSSQEW-------KR-----LGVEQ------L-----------------RL
| |.........   || . .    ..|....|. ....... |        | |       ..     |.||.                         .
dgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr..kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqyt

STVDMTGIPTLDNLQKGVQFALKYQS---LGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK
.  |..  |.|. |.. .... ....    | .|.|||.|| .|..|..||||.       ......|||. . . |...   |.|.  | .. .
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
subfamily_DSP12_pd Subfamily DSP12 40-186 5.4e-20 66.3 In-house 4-143 (155) alignment 
Range on Protein: 40-186
Range on HMM: 4-143/155.0
RIDPTVLLGALPLRSLTrQLVQDENVRGVITMNEEYEtrflcnSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRS
||.| ..|| |.    . .| .. ..  |... .|         . . |.  |... .  .|.   . |..|.. |.|  .  . .. |.|||.|| |||
rilpglylggleavqee.ellkelkithvlsvikeel......pehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

ATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQI
.|.|.|||.. .|.| |.|.... .... |.   | |. || |.|  
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0045450 (Phosphotyrosine protein) phosphatases II 47-182 6.5e-20 67.5 In-house 111-299 (307) alignment 
Range on Protein: 47-182
Range on HMM: 111-299/307.0
LGALPLRSlTR----QLVQDENVRGVITMNEEYETRF---------------------LCNSS-----------------QEWKRLGVEQLRLSTVDMTG
.   || . |     .......|. .....|. |  .                      . |                  .. . . | ..   .   .|
atqgPlpe.tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

IP-TLDNLQKGVQFALKYQS---LGQCVYVHCKAGRSRSATMVAAYLIQVHK--------WSPEEAVRAIAKIRSYIHIRPGQLDVLKEF
.| ... | . .. ..|...    | .|.|||.|| .|..|..||||. ..         ....|||. . . |. .   |.|.  | |.
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 58-184 1.3e-19 66.1 In-house 104-273 (317) alignment 
Range on Protein: 58-184
Range on HMM: 104-273/317.0
QLVQDENVRGVITMNEEYETR------------------------------------FLCNSSQEWKRLGVEQLRLSTVDMTGIP-TLDNLQKGVQFALK
..|....|. .....|. |                                      . .  ... . . | ..   . .  |.| ..| |.. .... .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

YQSL-GQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK
...  | .| |||.|| .|..|..||||.     . .....||||. . . |...   |.|.  | ... 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0043336 (Phosphotyrosine protein) phosphatases II 42-182 6.4e-19 63.9 In-house 87-272 (278) alignment 
Range on Protein: 42-182
Range on HMM: 87-272/278.0
DPTVLLGALPLRSLT---RQLVQDENVRGVITMNEEYET----------------------------------RFLCNSS-QEWKRLGVEQLRLSTVDMT
 .....   || . .   ...|....|. .....|. |                                   | |. .  .. . . | ..    .   
prkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdh

GIP-TLDNLQKGVQFALKYQS-LGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEF
|.| .|. |.. .........  . .|.|||.|| .|..|..|.||.       .....||||. . . |  .   | |.  | |.
gvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 58-186 9.5e-19 63.5 In-house 40-224 (272) alignment 
Range on Protein: 58-186
Range on HMM: 40-224/272.0
QLvQDENVRGVITMNEEYETRFlCNSSQEWkrLGVEQLRLSTVDMTGIPTL-------------------------------------------------
.| ...... .... .|.|  . .. ...|   |.. |.|...|..  . |                                                 
rl.kelgiktivdLrseeErgr.lkcdryw..pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgv

--DNLQKGVQFALKyqslGQCVYVHCKAGRSRSATMVAAYLIQvHKWS--------------PEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQI
  . | . ... |.    |. |.|||.||..|..|.||..|.  . .|              .||||. . ..| ...  ..|.  | |. ...
pqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
DSPc Dual specificity phosphatase, catalytic domain 63-184 2.3e-18 61.4 Pfam-A 17-132 (133) alignment 
Range on Protein: 63-184
Range on HMM: 17-132/133.0
ENVRGVITMNEEYET-RFLCNSSQEWKRLGVEQlrlstvdMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRA
 ..  || . .| .  .. ..|..|  |. ||.       .|   . . |.. |.|  | .. |. |.|||.|| |||||...|||.. ...| .||...
lgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyef

IAKIRSYIHIRPGQLDVLKEFHK
. . || |  . |.|  | |. .
vkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 63-184 2.3e-18 61.4 In-house 17-132 (133) alignment 
Range on Protein: 63-184
Range on HMM: 17-132/133.0
ENVRGVITMNEEYET-RFLCNSSQEWKRLGVEQlrlstvdMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRA
 ..  || . .| .  .. ..|..|  |. ||.       .|   . . |.. |.|  | .. |. |.|||.|| |||||...|||.. ...| .||...
lgitlvinvtkevpnnnaikkseieylripved.......etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyef

IAKIRSYIHIRPGQLDVLKEFHK
. . || |  . |.|  | |. .
vkerrskispnagflrqLleyer
PTPc_motif_SM00404 40-184 5.2e-18 60.3 In-house 4-139 (140) alignment 
Range on Protein: 40-184
Range on HMM: 4-139/140.0
RIDPTVLLGALPLRSlTRQLVQDENVRGVITMNEEYETRflcnssqeWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRS
|| | . || ..  .  ..| .  ... || . || . .         .  |.. |..   | .  .... |.| ..|  . .. |. |.|||.|| |||
rilphlylgskskaq.npallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRS

ATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHK
||...|||.. ...| .||.... . |. |  . . .  | |. |
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0047943 (Phosphotyrosine protein) phosphatases II 58-179 1.8e-16 55.9 In-house 95-264 (273) alignment 
Range on Protein: 58-179
Range on HMM: 95-264/273.0
QLVQDENVRGVITMNEEYETRF------LCNSS---------------------------------QEWKRLGVEQLRLS-TVDMTGIPTLDNLQKGVQF
..| ..||| .....|..|           ..                                  .  . . | ..      |.   |.|. | . ...
rmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

ALKYQS---LGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVL
. |...    .  |.|||.|| .|..|..|..|.       ......|||. . . | .. . | |.  |
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
subfamily_DSP19_pd Subfamily DSP19 93-186 2.1e-16 54.6 In-house 57-150 (152) alignment 
Range on Protein: 93-186
Range on HMM: 57-150/152.0
EQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQI
. | .. .|      |. |.. ..|  . .|   .|.|||.||.||||..| |||.. .. | |||.. . ..|  |.   | .  |||.....
tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0048567 (Phosphotyrosine protein) phosphatases II 68-183 8.6e-16 52.6 In-house 4-135 (157) alignment 
Range on Protein: 68-183
Range on HMM: 4-135/157.0
VITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVD-M--TGIPTLD---NLQKGVQFALKYQ-------SLGQCVYVHCKAGR---SRSATMVAAYLIQVH
.. ..| .. |.. .. .....  .. | .|. | .        .   ||   ..|.||           |. ..||||||.   .|.||....||| ..
ngdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl

KWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFH
...||||.. .. .|  . . . .  .|  ..
gftpeeaiaplrivrpgsvpfrdasyllslyn
0036941 (Phosphotyrosine protein) phosphatases II 58-183 1.3e-15 52.9 In-house 96-273 (297) alignment 
Range on Protein: 58-183
Range on HMM: 96-273/297.0
QLVQDENVRGVITMNEEYETRF---------LCNSSQEWKRLGVEQLRLST-------------------------------VDMTGIPT-LDNLQKGVQ
..| ..||. .....|..|  .           ..|.. ... |. |. ..                                .  |.|.  . | . ..
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

FALKYQS---LGQCVYVHCKAGRSRSATMVAAYLI--------QVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFH
...|...    |  |.|||.|| .||.|..||.|.          ..... |||. . . |  .   ..|.  | |. 
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_DSP15_pd Subfamily DSP15 56-188 1.4e-15 51.7 In-house 19-141 (151) alignment 
Range on Protein: 56-188
Range on HMM: 19-141/151.0
TRQLVQDENVRGVITMNEeyetrflcnsSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSP
 ..|....|.  ......          ...  .  .| . ..  | ..      ... |.|  | .. .. |.||| || |||.|.|.|||. | . . 
deelLkeknithilsvhd..........nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnw

EEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITA
..|...| . ||  .   |    |||..|. ..
rdalevikaaRsvanPnfGfkrqlkeyektklk
0051299 (Phosphotyrosine protein) phosphatases II 58-178 6.1e-15 50.9 In-house 110-277 (288) alignment 
Range on Protein: 58-178
Range on HMM: 110-277/288.0
QLVQDENVRGVITMNEEYET-----------------------------------RFLCNSS-----QEWKRLGVEQLRLSTVDMTGIPT-LDNLQKGVQ
..| ..||| ........|                                    | |. .      .. . . | ..   .    |.|. .. | . ..
rmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflr

FALKY-QSLGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLDV
.. |. .| | .|.|||.|| .|..|..|..|.     . ......|||. . . | .. . | |.  
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrf
subfamily_STYXL1_pd Subfamily STYXL1 54-187 1.5e-14 47.5 In-house 27-154 (157) alignment 
Range on Protein: 54-187
Range on HMM: 27-154/157.0
SLTRQLVQDENVRGVITMNEEYETrfLCNSSQEwkrlGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKW
.  ... .|  |.... .  . .   | .. ..     .. |...  |      |..|.. |||  |..  |..| |  . | ||||....|||.  .|.
aqnpaikkdlkvkahvnvsmdadk..liagvad....vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskki

SPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
. ..|   . | .. .. . . .. |.|. ||. 
tlkkaykylkkCkenvkPnrafveqlseWekqll
0050432 (Phosphotyrosine protein) phosphatases II 58-177 2.5e-14 48.8 In-house 126-289 (308) alignment 
Range on Protein: 58-177
Range on HMM: 126-289/308.0
QLVQDENVRGVITMNEEYETR------FLCN---------------------------------SSQEWKRLGVEQLRLSTVDMTGIPT-LDNLQKGVQF
..| ..||| ........|        .  .                                  ... . . | ..   .    |.|. .. | . ...
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

ALKYQsLGQCVYVHCKAGRSRSATMVAAYLI-----QVHKWSPEEAVRAIAKIRSYIHIRPGQLD
. |..  |  ..|||.|| .|..|..|..|.     . ......|||. . . | .  . | |. 
vrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
subfamily_DSP14_pd Subfamily DSP14 91-191 5.1e-14 46.5 In-house 49-149 (157) alignment 
Range on Protein: 91-191
Range on HMM: 49-149/157.0
GVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARA
..|....   |..     . ... ..   . .  | .. |||.||.||||... |||.. .| | .|| ... ..|. |.   |    | .. |......
diervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks

T
.
s
subfamily_DSP1_pd Subfamily DSP1 56-190 8.4e-14 46.0 In-house 35-160 (163) alignment 
Range on Protein: 56-190
Range on HMM: 35-160/163.0
TRQLVQDENVRGVITMNEEYETRFlcNSSQEWKRLGVEQLRLSTVdmtgiptLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSP
 .........  .. . .| .  |  ..  |.|.| .|  .   .          ... ..|  . .. .  |..||.|| |||.|.. |||.. ...| 
nleiLkslgitailnvskeldnvf..edlfeYkklkleDspkadi.......slvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsl

EEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARA
|||   . . || |.   |    |....|..... 
eeafdfvkqrRsiisPnagFvlqLlnyekklllel
0046845 (Phosphotyrosine protein) phosphatases II 58-180 1.5e-13 46.3 In-house 95-267 (284) alignment 
Range on Protein: 58-180
Range on HMM: 95-267/284.0
QLVQDENVRGVITMNEEYETR------------------------------------FLCNSSQ--EWKRLGVEQLRLSTVDMTGIP-TLDNLQKGVQFA
..| ..||| .....|. |                                       |. .    . . . | ..   .    |.| ....|.. ....
rmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

LKYQSL---GQCVYVHCKAGRSRSATMVAAYLIQVH--------KWSPEEAVRAIAKIRSYIHIRPGQLDVLK
 ....    |  . |||.|| .|..|..|..|.  .        .....|||. . . | .    . |.  . 
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy
subfamily_DSP8_pd Subfamily DSP8 38-188 4e-13 43.2 In-house 15-156 (159) alignment 
Range on Protein: 38-188
Range on HMM: 15-156/159.0
YHRIDPTVLLGALpLRSLTRQLVQDENVRGVITMNEEyetrflCNSSQEWKRLGveQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRS
 .|| . . ||.    .| ..|... ..  |. ....      | ...| |      ||.   |      |. ..| |.|  | .|  ..| ||. ||.|
ptrilknlylGsq.kdvlseellsklgisyvlnasns......cpkleelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGis

RSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITA
||||.. ||...  . | .|| | . . |  |      |. | |..|... 
rsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 58-183 4.1e-13 43.1 In-house 27-144 (148) alignment 
Range on Protein: 58-183
Range on HMM: 27-144/148.0
QLVQDENVRGVITMNEEYETRFLCNssqewkrlGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEE
. ... .|  ......| .  .           |.| | ..  |          .. ..|  | .. |. | ||.. |.|||. .. ..||. .. | .|
ealkalgvtrivnatkerdnaldqr........gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslke

AVRAIAKIRSYIHIRPGQLDVLKEFH
|. ..   | |.. ..| |  | |. 
alalvkskrryvdpnlgfLkqLaele
subfamily_DSP23_pd Subfamily DSP23 49-179 9.8e-13 43.0 In-house 16-132 (148) alignment 
Range on Protein: 49-179
Range on HMM: 16-132/148.0
ALPLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRlstvdmtgIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLI
|||      . . |  || .... || . .  .  .  ..||....           |.|..... |.   . .. .. | |||  || |. ||.| ||.
alprlpdqyrylldlgvrylvslteegrphveatpnltlvrlriddyh........ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv

QVHKWSpeeAVRAIAKIRsyiHIRPGQLDVL
. .| .   |  |||..|   . ||| .. .
kerkla...aaeaiaevr...rlrpgsvetv
subfamily_Slingshot_pd Subfamily Slingshot 96-192 2.2e-12 40.7 In-house 67-163 (169) alignment 
Range on Protein: 96-192
Range on HMM: 67-163/169.0
RLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARATK
...  |      |.. ..  .|  | .. |  | |||| | ||||. | || .. ...| |||.. . . || |.  .| |  |.|..  ..|.  .
nirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqr
subfamily_DSP3_pd Subfamily DSP3 125-187 3.3e-12 40.4 In-house 97-158 (162) alignment 
Range on Protein: 125-187
Range on HMM: 97-158/162.0
GQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSyIHIRPGQLDVLKEFHKQIT
   |.|||..| |||||.| |||. ..| .  ||.|...| |. |    | |  |.|......
egkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelk
subfamily_DSP10_pd Subfamily DSP10 96-187 8.8e-12 39.2 In-house 63-154 (159) alignment 
Range on Protein: 96-187
Range on HMM: 63-154/159.0
RLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
|.   | . .    . .. ..|  . .. |. | |||.|| |||||.| |||..  . | ..| . . . |. |    . .  |.|| |...
ripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_MKPLT_pd Subfamily MKPLT 73-186 1.1e-11 38.5 In-house 44-160 (164) alignment 
Range on Protein: 73-186
Range on HMM: 44-160/164.0
EEYETRFLCNSSQEWKRL---GVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYI
.. ..   .| ||| |      || |.... | .     . |..  .|  .    | .|.|||  |.|||...  |.||. ..|  .||   . . || .
kdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv

HIRPGQLDVLKEFHKQI
    | |  | .| . |
apnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 73-186 1.1e-11 38.5 In-house 44-160 (164) alignment 
Range on Protein: 73-186
Range on HMM: 44-160/164.0
EEYETRFLCNSSQEWKRL---GVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYI
.. ..   .| ||| |      || |.... | .     . |..  .|  .    | .|.|||  |.|||...  |.||. ..|  .||   . . || .
kdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv

HIRPGQLDVLKEFHKQI
    | |  | .| . |
apnrGflkqlakfeeli
subfamily_PTPDC1_pd Subfamily PTPDC1 111-189 1.1e-10 36.3 In-house 104-178 (182) alignment 
Range on Protein: 111-189
Range on HMM: 104-178/182.0
LQKGVQFALKYQslgqCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITAR
. | |.|||. .     | ||| ||. |   ..|.||. ... ..|.|.. . . |.      .|....|||.. .. .
ivkvvafalqeg....kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflipl
subfamily_RNGTT_pd Subfamily RNGTT 83-167 1.6e-10 34.9 In-house 69-155 (189) alignment 
Range on Protein: 83-167
Range on HMM: 69-155/189.0
SSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKY--QSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRS
  .| .. |... .|..      |. .. ..  .   ..  ..  . . |||. |  |.  ....||.....|| |.||.. || | 
dkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
subfamily_LRR-DSP_pd Subfamily LRR-DSP 127-187 1.9e-10 34.3 In-house 199-259 (263) alignment 
Range on Protein: 127-187
Range on HMM: 199-259/263.0
CVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
 | |||.|| |||.|.| .||.. ..   .||.  . | |. |.  || .| || . |.. 
GvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_Laforin_pd Subfamily Laforin 85-171 2.2e-10 33.7 In-house 70-156 (183) alignment 
Range on Protein: 85-171
Range on HMM: 70-156/183.0
QEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHI
. .|  |.  . | | |..    ..|| ..| .       |. |||||.||  ||...|  .|  | .||       .   |  ..|
klykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyi
subfamily_DSP6_pd Subfamily DSP6 54-187 5.5e-10 33.0 In-house 29-155 (158) alignment 
Range on Protein: 54-187
Range on HMM: 29-155/158.0
SLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRlsTVDMTgiptlDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKW
.  ...... ... |. . .. .  |  . . ..... .|     . ...       . . ..|  . .|  . | ||| || ||| |.. |||.. .. 
asnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhl..sqnla.....kffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklal

SPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQIT
| ..|   . | .| |      .. |..| ....
slndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP11_pd Subfamily DSP11 83-182 3.5e-09 30.8 In-house 71-173 (178) alignment 
Range on Protein: 83-182
Range on HMM: 71-173/178.0
SSQEWKRLGVEQLRLSTVDMtGIPTLDNLQKGVQFAL----KYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDV
. .|..  ||. |.| ..    .|. . ..|  ..      | .  .. . |||  |  |.  ..  |||.|. ..||.|..|  ..| .   |   |. 
kkkeltdegvkylklncpGh.evpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkd

LKEF
||. 
Lkkl
subfamily_CDC14_pd Subfamily CDC14 59-167 1.3e-08 29.1 In-house 207-305 (328) alignment 
Range on Protein: 59-167
Range on HMM: 207-305/328.0
LVQDENVRGVITMNEEyetrflCNSSQEWKRLGVEQLRLSTVDMTgIPTLDNLQKGVQFALKYqslGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEA
  ...||. |. .|..          ....  |..   |  .| . .|.   ..| .. | |       . ||||||  |  |..|.||.. .. . .||
yfrknnvttvvrLnkk......lYdakkftdaGfdhkDlffiDGs.tPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VRAIAKIRS
.  .  .| 
iawlricrP
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 59-186 3e-08 27.1 In-house 23-152 (154) alignment 
Range on Protein: 59-186
Range on HMM: 23-152/154.0
LVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQ--SLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPE
..|  |.. .. .    .  |  . |.    . .| |.|   | .    ...|.|  .|  .       . | ||...| ||||... .||..  | |  
dlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkisls

EAVRAIAKIRSYIHIRPGQLDVLKEFHKQI
.|.  . . |  |.   | |. |. | |. 
lalellkdsryiikPnqGflkqleifekel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 84-166 3.4e-08 26.7 In-house 39-121 (145) alignment 
Range on Protein: 84-166
Range on HMM: 39-121/145.0
SQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIR
||| |   .| | ... |.      . ...  .|  | .  |  |.||| || ||| |.  |.|..  . .  || | .   |
sqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnr
subfamily_PTEN_pd Subfamily PTEN 112-168 3.9e-08 28.5 In-house 99-158 (184) alignment 
Range on Protein: 112-168
Range on HMM: 99-158/184.0
QKGVQFALKYQ--SLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPE-EAVRAIAKIRSY
.. |. . |.   .  . | ||||||. |. ....|||.. .... . ||..  |..|. 
eeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
subfamily_STYX_pd Subfamily STYX 111-188 1.4e-07 24.7 In-house 82-159 (166) alignment 
Range on Protein: 111-188
Range on HMM: 82-159/166.0
LQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITA
| .  .|  .  . |  | || .|| ||||..| ||... .     || . . . |  |    |  . |||..    |
lptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
PTPc_DSPc_SM00012 125-158 2.9e-07 26.0 In-house 39-72 (105) alignment 
Range on Protein: 125-158
Range on HMM: 39-72/105.0
GQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEA
.. | |||.|| .|..|.||....  . .. .. 
skpvvVhCsaGvgRtgtfvaldillqqleketke
subfamily_VSP_pd Subfamily VSP 73-153 6.8e-07 23.4 In-house 74-156 (212) alignment 
Range on Protein: 73-153
Range on HMM: 74-156/212.0
EEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKY--QSLGQCVYVHCKAGRSRSATMVAAYLIQVHKW
..|.   ||   .  ..   ....  ..|   .|.|..| .  . . ..  . | . . .||| |. |. |.| |.|.. . .
dhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseif
subfamily_MSG5_pd Subfamily MSG5 123-163 7.5e-07 22.4 In-house 97-137 (165) alignment 
Range on Protein: 123-163
Range on HMM: 97-137/165.0
SLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIA
| .. . |||. | ||||... ||... .. | ..|   . 
skrkkilvhcqcglsrsaslivayimkyynlslrdaydklk
subfamily_Auxilin_pd Subfamily Auxilin 124-179 2e-06 20.6 In-house 101-157 (166) alignment 
Range on Protein: 124-179
Range on HMM: 101-157/166.0
LGQCVYVHCKAGRSRSATMVAAYLIQVHKW-SPEEAVRAIAKIRSYIHIRPGQLDVL
  . | |||| ||  ||..|.|.|. .. . .||.||| ..  |  | ..| .   |
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryl
subfamily_PRL_pd Subfamily PRL 122-185 3.9e-06 21.0 In-house 87-148 (151) alignment 
Range on Protein: 122-185
Range on HMM: 87-148/151.0
QSLGQCVYVHCKAGRSRSATMVAAYLIQVhKWSPEEAVRAIAKIRSYiHIRPGQLDVLKEFHKQ
.. ...| ||| ||  |.  .||  ||.    ..|.||. | . |    |   ||. |......
eepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekrrg.ainskqlkflekykak