Gene RNGTT in Homo sapiens

Synonym: CAP1A, HCE, HCE1, hCAP, RP3-488C13.1, RNGTT

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP040_AA protein Get Run
HsapP040_AA_14-184 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 7-195 1.8e-98 321.8 In-house 1-189 (189) alignment 
Range on Protein: 7-195
Range on HMM: 1-189/189.0
PPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETF
|.|||||||.|. .|..|||.||.|..|||...||||||.||||..|||.||||.||..|||||||.||....|||||||.||||.|.||.|..|....|
PerWlnCPrkgkliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkef

IRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFE
|.|.|.|...|| |.||||||||||||||||...||||.|||.|||||.||.||||||||.||||||.|||.|.|||...| |||||.|
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapelpdwcle
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 272-460 5.6e-75 240.5 Pfam-A 1-192 (192) alignment 
Range on Protein: 272-460
Range on HMM: 1-192/192.0
QPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTnEVFMIDRDNSVFHVSNLEFPFRKD--LRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNS
||||....|.|||. |.|.||.||||.|...||. . ||..|||||.|..|.||.||....   ......||||||..||.|......|||||||...|.
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

QPVGDCDFNVRLQCIEREIISPRHEKM-KTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTG-KYKPGRCDDILKWK
. | ..... ||.....|||.||.|.. ||..|....|||.||.| |.......|||. ...|..|||.||||||... .|..||....||||
elvserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 5-197 3e-62 205.0 In-house 1-193 (194) alignment 
Range on Protein: 5-197
Range on HMM: 1-193/194.0
KIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTE
|.|.|||...| |... |||...|. |  ..|... |..||.|..| .|||.|.||.||..|||||.|.||....|| ||.|.||.....|..|..|.. 
klPdrwlkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

TFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDD
.|..|...|....|.....|||..|..|||.|..|.|......| |.|.|.|...||..|.. |||..|..||.....|. .|  |....||.
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpelllede
subfamily_DSP11_pd Subfamily DSP11 6-176 4.9e-45 147.6 In-house 1-173 (178) alignment 
Range on Protein: 6-176
Range on HMM: 1-173/178.0
IPPRWLNCPRRGQPVAG-RFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGEcPTTENTE
.| || .    |. . | ||...|| |  ..|..|.||.|| |. | . |.. . |.||..||||| |.|.......||.|| ||.| ||   |. |  .
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelvk

TFIRLCERFNE--RNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRR
.|..  ..| |   .  .||||||||| ||||.||| .|....... | |. .| .||   . . .|||.| ..
kfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkkl
mRNA_cap_C mRNA capping enzyme, C-terminal domain 464-560 1.8e-35 110.9 Pfam-A 2-105 (105) alignment 
Range on Protein: 464-560
Range on HMM: 2-105/105.0
LNSVDFRLKITRMGGEGLLPQNVGLL-YV-GGYErPF----AQIKVTKELKQYDNKIIECKFEN--NSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTK
||.|||.||.... ..|||....|.| || ||.. .|     . |.....|....||.|||...  ..|.|.|.|.||| || ..||..|..||...|||
lntvDfllklekeeedglLeeekgkldyveggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednvtk

EMLFE
|.|.|
eeLle
0044763 (Phosphotyrosine protein) phosphatases II 53-175 1e-23 79.3 In-house 43-165 (178) alignment 
Range on Protein: 53-175
Range on HMM: 43-165/178.0
YLKSLKVKmgLLVDLTNTSRFY----DRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNE-RNppELIGVHCTHGFNRTGFLICAFLVEKMDW
.|| |...  ..|.||.. . .    |. . |..||.|... . .||... .| .. |....|.. . ..  . . |||..|..|.| |..|.|. |...
llkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklgl

SIEAAVATFAQARPpGIYKGDYLKELFR
|.|.|.. . ..|| ...  ..|. | .
sleeaielvrerRp.ivpnpgqlrqLye
0036282 (Phosphotyrosine protein) phosphatases II 42-174 1.3e-23 79.0 In-house 32-163 (174) alignment 
Range on Protein: 42-174
Range on HMM: 32-163/174.0
ENRFHPSMLSNYLKSLKVKMGLLVDLTNTsrfyDRNDIEKEGIKYIKLQCKGHGECPTTEnTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFL
  ... ... ..|..   ....  .....    .|.| |..||.|..| . .||. ....  ..|....|.. ...|   . |||..|..|||.|..|.|
lkelgittvvmlleekelglykcinywpe....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaayl

VEKMDW-SIEAAVATFAQAR---PPGIYKGDYLKELF
.... . | . |.......|   |....  .... | 
mlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0049772 (Phosphotyrosine protein) phosphatases II 34-181 3.3e-23 78.3 In-house 155-273 (314) alignment 
Range on Protein: 34-181
Range on HMM: 155-273/314.0
RydsqvaeeNRFHPSMLSNYLkslkvkmgllvdltntSRFYDRNDIEKEGIKYIKLQCKGhGECPTTENTETFIRLCERFnerNPPELIGVHCTHGFNRT
         |  ... | ..                 .. ||... |..||||. . . . |..|..|  . |....|..   .... . |||..| .||
g........neptaadlellk................eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRt

G-FLICAFLVEKMDWSIEAAVATFAQARPpgIYKGDYLKELFRRYGDIE
| |...|.|. ....|.| |.. . ..||  |.  . . | ...|  |.
gtfvvaaylmkllgvsleealedvrlkRp..inpnpgfieqleqyefil
0041856 (Phosphotyrosine protein) phosphatases II 52-177 6.1e-23 76.8 In-house 52-172 (182) alignment 
Range on Protein: 52-177
Range on HMM: 52-172/182.0
NYLKSLkvKMGLLVDLTntSRFYDRNDIEKEGIKYIKLQCKGHGECPttenTETFIRLCERFNErnPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEA
..||.|  . ...|.||  .. |. .. |..||.|..|.. .|| ..    ........|. .|  ... . |||..| .|||.|..|.|..|...|.| 
rmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvslee

AVATFAQARP-----PGIYKGDYLKELFRRY
||... ..||     |  |   .|..|....
avklvrsrRpgmvitpnqyfflqlallelll
0043147 (Phosphotyrosine protein) phosphatases II 44-173 9.9e-23 76.1 In-house 30-153 (172) alignment 
Range on Protein: 44-173
Range on HMM: 30-153/172.0
RFHPSMLSNYLKSLKVKMglLVDLTntSRFYDRNDIEKEGIKYIKLQCKGHGECpTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVE
|.. ..  ..||.|....  .|.||  ...||. . |..||.|. | .  || . ..|  . |.......  ..| . . |||..|..|||.|..|.|..
rntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml

kMDWSIEAAVATFAQARPPGIYKGDYLKEL
 ...|.| |||.. ..|| ...  .... |
.lglsleeavalvrekRpgavqnpsqyrfl
0048076 (Phosphotyrosine protein) phosphatases II 53-176 2e-21 71.6 In-house 24-138 (145) alignment 
Range on Protein: 53-176
Range on HMM: 24-138/145.0
YLKSLKVKMglLVDLtntsrFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAA
.||.|....  ...|      ..... |..||.|. | . .||. . .|  ..|....|.. ...  . . |||..| .|||.|..|.|. ....|.| |
llkdlgitt..vlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleea

VATFAQARPPGIYKGDYLKELFRR
.. . ..|| ...  ..|. |.. 
lelvrsqrpgavpnpgqlrflyef
0040438 (Phosphotyrosine protein) phosphatases II 60-209 2e-21 72.0 In-house 110-311 (317) alignment 
Range on Protein: 60-209
Range on HMM: 110-311/317.0
KMGLLVDLTNTSRFYD----------------------RNDIEKEGIKYIKLQC-------------------KGHGECPTTENTETFIRLCERFNErNP
. ...| ||..  . .                      .. .|..||.. .|..                     ||  |...    |........| .|
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dp

PELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIYKG-------DYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDG
.. . |||..| .|||..|.|.|.     .......| ||... ..|| ...         |.| |...|..  |.|....|....... .  .| ... 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke

KKE
|..
kel
0048179 (Phosphotyrosine protein) phosphatases II 51-175 2.4e-21 71.4 In-house 20-139 (144) alignment 
Range on Protein: 51-175
Range on HMM: 20-139/144.0
SNYLKSLKVKMGLLVDLTNTsrfYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIE
...    | . .....||..   |. .. |.|||.|..| . .||  . .|  ..|....|.. |..  . . |||..|..|||.|..|.|. |...|.|
ldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglsle

AAVATFAQARPPGIYKGDYLKELFR
 |.| . ..|| ...  ..|. | .
ealalvrsrrpgavpnpgqlrfLle
PTEN_1 34-180 1.1e-20 69.3 In-house 43-191 (196) alignment 
Range on Protein: 34-180
Range on HMM: 43-191/196.0
RYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNT--SRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFN
..| .. .... ..... . ||. .. . . ...     .| || .. .|.|..|...  . || ..  |  .   .. |   .... . . |||..| .
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDI
|.|....|.|..|. .. . |.. ....||||     ....| . . ..
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0049260 (Phosphotyrosine protein) phosphatases II 59-175 1.1e-20 69.3 In-house 30-144 (152) alignment 
Range on Protein: 59-175
Range on HMM: 30-144/152.0
VKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFnERNPPELIGVHCTHGFNRTGFLICAFLVEkMDWSIEAAVATFAQ
 ..|  . .. |.....  . ....|.|. |..  || .. ..  . .....|..  ... . . |||..|..|||.|..|.|.. ...|.| ||| . .
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

ARPPGIYKGDYLKELFR
.|| ...  ..|. |. 
kRpgavpnpgqlrflye
0040439 (Phosphotyrosine protein) phosphatases II 59-173 7.3e-20 67.1 In-house 77-238 (249) alignment 
Range on Protein: 59-173
Range on HMM: 77-238/249.0
VKMGLLVDLTNTSRF-------------------------------------------YDRNDIEKEGIKYIKLQckGHGECPTTENTETFIRLCERFNE
 . . .|.||.. ..                                           || ....  .| |...    || .|..| .  ||.... ..|
lgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkale

RN-PPELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIYKGDYLKEL
.. ... . |||..| .|||..|.|.|.     .. ....| ||... ..|| ...  .... |
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 58-166 3.3e-19 64.9 In-house 70-227 (243) alignment 
Range on Protein: 58-166
Range on HMM: 70-227/243.0
KVKMGLLVDLTNTS----------------------------------------RFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNER-
. . . .|.||..                                         . .| .| ....|.|  |   .||  ...|.   |.. .  | |. 
elgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieel

------NPPELIGVHCTHGFNRTGFLICAFLVEKM-DWSIEAAVATFAQARPP-GIYK
      .. . . |||..| .||| ||.|.|. .. ....| ||... . ||  ..  
lsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqt
0042113 (Phosphotyrosine protein) phosphatases II 60-167 5.5e-18 60.7 In-house 76-229 (245) alignment 
Range on Protein: 60-167
Range on HMM: 76-229/245.0
KMGLLVDLTNTSRFYD-----------------------------------------RNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNP
.   .|.||..  .                                           ..| ..|.| |  | . .||.....|  . |....... ....
gittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

PELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIYKG
.. . |||..| .||| .|.|.|.     . ...|.| ||. . . ||  .   
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp
0051082 (Phosphotyrosine protein) phosphatases II 54-163 7.1e-18 60.1 In-house 29-135 (151) alignment 
Range on Protein: 54-163
Range on HMM: 29-135/151.0
LKSLKVKMglLVDLTNTS-RFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNErNPPELIGVHCTHGFNRTGFLICAFLVEkMDWSIEAA
||.|..|.   |.|...  | |. .  ...||... ... .. . .. ......... | ... ...  . |||..| .|||.|....|.  ...|.|.|
lkelgikt..ivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

VATFAQARPPG
.. . . ||  
leeyrlkrpgv
0045450 (Phosphotyrosine protein) phosphatases II 64-170 8.2e-17 57.3 In-house 135-293 (307) alignment 
Range on Protein: 64-170
Range on HMM: 135-293/307.0
LVDLTNTSR-------------------------FYDRNDieKEGIKYIKLQC--------------------KGHGECPTTENTETFIRLCERFNERN-
.|.||..                           ... .   ..|... .|                       .|| .|..| .  ||.......|.. 
ivmltelvelgrekcaqywPdegeeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelp

PPELIGVHCTHGFNRTGFLICAFLVEKMD--------WSIEAAVATFAQARPPGIYKGDYL
... . |||..| .||| .|.|.|. ..         .... ||... . || ..   ...
kggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy
0046846 (Phosphotyrosine protein) phosphatases II 58-163 1.9e-15 52.5 In-house 45-154 (176) alignment 
Range on Protein: 58-163
Range on HMM: 45-154/176.0
KVKMGLLVDLTNT------SRFYDRNDIEKEGIKYIKLQCKGHGECPTtENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEK-MDWSIE
. . ...|.||.       . ... ...||.||.|. |    || ..  |  .......... ...  . . ||| .| .||| |..|.|.|. ...|.|
elgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsve

AAVATFAQARPPG
 |.|.. . ||.|
ealalvreqRplg
0039614 (Phosphotyrosine protein) phosphatases II 62-167 4.9e-15 51.2 In-house 127-275 (297) alignment 
Range on Protein: 62-167
Range on HMM: 127-275/297.0
GLLVDLTNTSRF--------------------YDRNDIEKEGIK-----------------YIKLQCKGHGECPTTENTETFIRLCERFNERN-PPELIG
  .| ||..                       . .. ....|..                 .  .    || .|..|    |..|........ ... . 
tvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

VHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIYKG
|||..| .||| .|.|.|.     .. ..... ||... ..|| ..   
VHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0045098 (Phosphotyrosine protein) phosphatases II 60-166 8.6e-15 50.3 In-house 132-257 (278) alignment 
Range on Protein: 60-166
Range on HMM: 132-257/278.0
KMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERN---------------PPELIGVHCTHGFNRTGFLICAFLVEK
..  |..|. |  .. |.|.|. |...... .   ...|... .  |..|.|. .|..               ... . ||| .| .||| |..|.|. .
ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle

M---DWSIEAAVATFAQARPP-GIYK
.    .... ||... . ||   .  
lleggvdlleavkelrsqRpglavqn
0043336 (Phosphotyrosine protein) phosphatases II 75-166 9.6e-14 47.0 In-house 167-262 (278) alignment 
Range on Protein: 75-166
Range on HMM: 167-262/278.0
DRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNErNPPELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIYK
 ... ....  |  |    || .....    |..   ...| .... . |||..| .||| .|...|.         ...| ||... . ||  .  
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqt
0051429 (Phosphotyrosine protein) phosphatases II 62-177 4.9e-13 44.8 In-house 47-228 (272) alignment 
Range on Protein: 62-177
Range on HMM: 47-228/272.0
GLLVDLTNTSRFYDRN-DIEKEGIKYIKLQCKGHGECPTTENT------------------------------------------------ETFIRLCER
   |||....     . | . .||.|. | . .... . . .                                                 |....| | 
ktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellel

FNErnpPELIGVHCTHGFNRTGFLICAFLVEkMDWS--------------IEAAVATFAQARPPGIYKGD-------YLKELFRRY
...   .. . |||..| .|||......|.  ...|              .|.||.   ..||  .   .       .|.||.|..
lld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0046845 (Phosphotyrosine protein) phosphatases II 77-165 1.2e-12 43.2 In-house 161-258 (284) alignment 
Range on Protein: 77-165
Range on HMM: 161-258/284.0
NDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNER-NPPELIGVHCTHGFNRTGFLICAFLVEKM--------DWSIEAAVATFAQARPPGIY
.. ... . .  ..   || .|..|.  .|.||.....|. .... | ||| .| .||| .|.. |. ..         .... ||. . . ||  . 
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq
subfamily_CDC14_pd Subfamily CDC14 29-162 7.1e-12 39.8 In-house 182-306 (328) alignment 
Range on Protein: 29-162
Range on HMM: 182-306/328.0
TMLGPRYDSQVAEEN-RFHPSMLSNYLKSLKVKMglLVDLTntSRFYDRNDIEKEGIKYIKLQCKgHGECPTTENTETFIRLCERFnernpPELIGVHCT
.. ||.  |....      |  | .| .. .|.   .| |   .. ||..  ...|...  |     | .|. .  . |....|.         | ||| 
alagPhnkskledgyplhaPeklleyfrknnvtt..vvrLn..kklYdakkftdaGfdhkDlffi.DGstPsdaivkkfleiaeka.....eGaiavhCk

HGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPP
 |. ||| || ..|...   . . |.| .  .|| 
aGLGrtGtLiacylmkhyrftaaeaiawlricrPG
0050432 (Phosphotyrosine protein) phosphatases II 84-164 7.4e-12 40.7 In-house 197-282 (308) alignment 
Range on Protein: 84-164
Range on HMM: 197-282/308.0
IKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGI
...  .....  .  . ...| .....|. ....|.. | ||| .| .||| .|.. |.     ..  .... ||... . ||  .
rtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv
DSPc Dual specificity phosphatase, catalytic domain 61-172 9.5e-12 39.9 Pfam-A 19-126 (133) alignment 
Range on Protein: 61-172
Range on HMM: 19-126/133.0
MGLLVDLTNTS--RfydrNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFneRNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQ
. | ...|..   .    |.|.|. |.|.... . . |  ...  |  ..  |..  ..  . . |||..| .|.. ||.|.| ... .|.. |.. . .
itlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvke

ARpPGIYKG-DYLKE
 | . | .   .|..
rr.skispnagflrq
DSPc Dual specificity phosphatase, catalytic domain 61-172 9.5e-12 39.9 In-house 19-126 (133) alignment 
Range on Protein: 61-172
Range on HMM: 19-126/133.0
MGLLVDLTNTS--RfydrNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFneRNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQ
. | ...|..   .    |.|.|. |.|.... . . |  ...  |  ..  |..  ..  . . |||..| .|.. ||.|.| ... .|.. |.. . .
itlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvke

ARpPGIYKG-DYLKE
 | . | .   .|..
rr.skispnagflrq
0047943 (Phosphotyrosine protein) phosphatases II 80-165 2.4e-11 39.1 In-house 165-256 (273) alignment 
Range on Protein: 80-165
Range on HMM: 165-256/273.0
EKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERN-PPELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGIY
... . .  .    || .|..|   .||.|.....| .  .. . ||| .| .||| .|...|.     ..  .... ||. . . || ...
srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 98-166 5.7e-11 37.0 In-house 51-124 (157) alignment 
Range on Protein: 98-166
Range on HMM: 51-124/157.0
PTTENTETFIRLCERFNE--RNPPELIGVHCTHGF---NRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYK
..   .  ||.. ..| .  .. .  | |||..|     ||..||...|. ..... | |.| ....||. .. 
lnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf
0051299 (Phosphotyrosine protein) phosphatases II 78-164 8.5e-11 37.3 In-house 176-269 (288) alignment 
Range on Protein: 78-164
Range on HMM: 176-269/288.0
DIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNER--NPPELIGVHCTHGFNRTGFLICAFLV-----EKMDWSIEAAVATFAQARPPGI
| ..| .... .....  .  . ...| ..........   ...  . ||| .| .||| .|...|.     ..  .... ||... . ||  .
dgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
subfamily_DSP23_pd Subfamily DSP23 82-164 2.2e-10 35.4 In-house 50-129 (148) alignment 
Range on Protein: 82-164
Range on HMM: 50-129/148.0
EGIKYIKLQCKGHgECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGI
 .. . .|. . .   |. |. . |.|. |  .|.|  | ..|||  |. ||| ..  .|| . . .   |.|   . ||  .
pnltlvrlriddy.hppaleqvvefvrvveeaeekn..eavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsv
PTPc_motif_SM00404 72-174 4.9e-10 34.4 In-house 41-135 (140) alignment 
Range on Protein: 72-174
Range on HMM: 41-135/140.0
RfydrndIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFneRNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARpPGIYKG-DYL
.       |..|....... . ... ....  .  ..  |..  ..  . . |||..| .|.. ||.|.| ... .|...|.  . . | | | .   ..
t......kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfv

KELF
..|.
rqLi
subfamily_PRL_pd Subfamily PRL 50-160 6e-10 33.4 In-house 23-130 (151) alignment 
Range on Protein: 50-160
Range on HMM: 23-130/151.0
LSNYLKSLKVK-MGLLVDLTNTSrfYDRNDIEKEGIKYIKLQCKgHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKmDWS
|... ..|| . .  .|   ...  || . .|||||. . |. .  |  |..|  | ...|...  ...| . ..|||  |. |.  |..  |.|.   .
lekfieelkkeevktvvrvcept..ydteklekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmk

IEAAVATFAQAR
 | ||    . |
yedavefirekr
0036941 (Phosphotyrosine protein) phosphatases II 89-164 1.4e-09 33.1 In-house 173-260 (297) alignment 
Range on Protein: 89-164
Range on HMM: 173-260/297.0
LQCKGHGECPTTENTETFIRLCERFNERN----PPELIGVHCTHGFNRTGFLICAFLV--------EKMDWSIEAAVATFAQARPPGI
....|  .  . |.........|......    ... . ||| .| .|.| .|.|.|.        .   ..|  || .. . ||  .
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgav
subfamily_PTEN_pd Subfamily PTEN 71-160 1.8e-08 29.5 In-house 70-156 (184) alignment 
Range on Protein: 71-160
Range on HMM: 70-156/184.0
SRFYDRNDIEKegiKYIKLQCKGHgECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIE-AAVATFAQAR
 | || .....   . ...... | . |. |  |....  |.. |... ... |||  |  ||| ||.|.|.... .. .  |.. ||.||
erkydskkfdg...rvavypfdDh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_PTPDC1_pd Subfamily PTPDC1 74-170 1.9e-08 29.0 In-house 73-165 (182) alignment 
Range on Protein: 74-170
Range on HMM: 73-165/182.0
YDRNDIEKEGIKYIKLQCKGHGECPtTENTETFIRLCERFNERNppeLIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYL
|| ... ..|| . ..  | .| ..  |.  . ... .   ...    ..|||  |  ||| ||...|| . . . | |. .  . ||  |.  . .
YdlealmeqgiyvynfgwkDygvas.leriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqv
subfamily_PTPMT1_pd Subfamily PTPMT1 78-161 3.7e-07 24.7 In-house 68-149 (171) alignment 
Range on Protein: 78-161
Range on HMM: 68-149/171.0
DIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNppELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARP
. .|.|.....|. . . | |..|. |  ... |.. ..   . . |||  |  |.. |. ..|. |  .| | |. . .. |.
ewkklgveqlqlatvDfteapdleklekgvefiekvaskg..krvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk
PTPc_DSPc_SM00012 90-142 6.7e-07 24.8 In-house 9-62 (105) alignment 
Range on Protein: 90-142
Range on HMM: 9-62/105.0
QCKGHgECPT-TENTETFIRLCERFNERNP-PELIGVHCTHGFNRTGFLICAFLV
... | ..|. ...  ...| ...... .   . . ||| .| .||| .... ..
gwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldil
subfamily_VSP_pd Subfamily VSP 72-146 1.1e-06 22.8 In-house 85-155 (212) alignment 
Range on Protein: 72-146
Range on HMM: 85-155/212.0
RFYDRNDIEKEgIkyIKLQCKGHgECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMD
| ||.. .... .  ....   | . |. |.  .| .  . . |... ... .||  | .||| ..||.|..   
raydekyfnnr.v..kriliddh.nvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllasei
DNA_ligase_A_M ATP dependent DNA ligase domain 288-458 4.3e-06 15.3 Pfam-A 20-200 (202) alignment 
Range on Protein: 288-458
Range on HMM: 20-200/202.0
PYKVSWKADGTRymMLID-GTNEVFMIDRDNSVFHVS-NLEFPFRKDLRM-HLSNTLLDGEMII-DRVNGQAV----------------------PRYLI
.. |..| || |  . ..  ..|| .. |    .       . . |. .  . .. .||||... |. .|..                       .....
afiveeKyDGeR..vqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsffv

YDIIKFNSQPVGDCDFNVRLQCIEREIisprhekmktglidktQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIF-QPTGKYKPGRC-DDILK
.|.. .. ... |  .. | . .|. .                .|.          .. . . ||  ... ......|... .| .||.||.   ..||
FDvlyldgesltdepleeRrklLeeif................kesenrieiaetlevndveeleelleevikeglEGvvlKdpdskYepgkrssnwlK
subfamily_DSP12_pd Subfamily DSP12 117-161 9.8e-06 20.0 In-house 80-124 (155) alignment 
Range on Protein: 117-161
Range on HMM: 80-124/155.0
NPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARP
.  . . |||. |  |   .. |.|. | ..|.| |. .  ...|
eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp