Gene MTM1 in Homo sapiens

Synonym: CNM, MTMX, XLMTM, MTM1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP046_AA protein Get Run
HsapP046_AA_169-552 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR1_pd Subfamily MTMR1 165-551 4.5e-206 676.6 In-house 1-389 (389) alignment 
Range on Protein: 165-551
Range on HMM: 1-389/389.0
KFNVDGWTVYNPVEEYRRQGLPNH-HWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKD
|.. |||.||.|..|..|.||.|. .|||| .||.|||||||||.||||  .||.||..||.|||..|.|||||...||..||.|.||||||.||||.|.
klkedGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrske

DEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTG
|||||..|.|.|.| .||.|.|||.|||||||||.|.||||..||.||||.|||||||||.||||||.|..|.|||....|||.||||.|||||||.|.|
dekylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilag

AIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAF
|.....||.. |.||||||||||||||||||||||.|||.||.|||||.|..|||.||||||..|.||||||..||.|||.||||||||||...||||||
avkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAF

EFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKE-INRVLYPVASMRHLELWVNYYIRWNPR
||||.|||..|||||||.|||||||.|..|...||.|.|||||| .||.||.|.||.|..|  ..||||.||.|.||||..||.|||||
efneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwnpr
0040695 (Phosphotyrosine protein) phosphatases II 166-550 1.2e-160 528.3 In-house 3-387 (388) alignment 
Range on Protein: 166-550
Range on HMM: 3-387/388.0
FNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDE
. ..||..|....|. |.||....|||...|. ||||..||||||||. .||..|.|||.|||..||||||..||.|. |..|.||||||....|...||
lleegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrslede

KYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAI
|.|. |...... |||.|.|.|| .||.||.|.|||.|. ||| ||||.||.|.||||.||||.|. |...........||.||...||..|||.| .|.
klleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklilelav

QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEF
 .......|.||||||||||||||.||.|||.|.||..||..||| .|..|||.|||||||.|.||..... . ..||.||.|.|||||. .||||||||
livklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeF

NEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNP
||..|. ..||||||||||||||.|  | . .| |||.||||...|.|..|.||.|  . . ||.|. |...| || .||.||.|
nerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrwlp
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 161-549 3.2e-158 519.1 In-house 4-403 (404) alignment 
Range on Protein: 161-549
Range on HMM: 4-403/404.0
LNEEKFN--VDGWTVYNPVEEYRRQGLPNH-HWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMS
 ..||.    |||..|.. |||.|.|.... .|||. ||. ||||.||| ||||| . ||..| .||.|||..|||||||.|......|.|.||||||..
sysekksvledgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGlt

GKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEE-SHWLSSLESTHWLEH
..| ..|||... || ...| ..| | ||||..|||||.|.| |||. . |.|.|. || |.||| .||||||.|..|  ..|. ..||| |||..||.|
ksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldh

IKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKnHTDADRSPIFLQFIDCVWQMS
|||.|.|. .... . . |||||||||||||||.||.||..|.||..|| ||||..|..|||.|||||||.|||. .. . . .||||||||||||.|. 
iklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqtte.kssdersPiflqFidcvyqlt

KQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFY----TKEINRVLYPV----ASMRHLELWVNYYIRW
||||| |||||.||| |||.||||||||||...|  |....... |||||.|...||... ||.|    ... ...        |......|| .||.||
kqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWseyylrw

N
.
r
Myotub-related Myotubularin-like phosphatase domain 164-495 8.8e-150 491.3 Pfam-A 14-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 164-495 8.8e-150 491.3 In-house 14-352 (353) alignment
subfamily_MTMR6_pd Subfamily MTMR6 162-549 1.3e-147 484.2 In-house 10-396 (397) alignment 
Range on Protein: 162-549
Range on HMM: 10-396/397.0
NEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGkRN
.... .|.||. ..  .|| |.|.||..| .| .|| ||||||||  |.|| .|. . |   . |||..|.||||..| ||.. | |||||| |.|  | 
kdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rc

KDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYP-NVEESHWLSSLESTHWLEHIKLV
..||| |..||..| . . | . |.|| .||.||||.| |||..| |.| .. |..|.|||||||||.|. ..|   .   |..||.|||. || ||| |
ledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikav

LTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHtdADRSPIFLQFIDCVWQMSKQFP
|  .| .|  |.. . ||||||||||||||| .||| |.||..||.|.|| .|..|||.|||||| .| |. |...   . ||||.||..||||. .|||
ldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldeds..kevsPiftqflecvwqlleqfp

TAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEIN-RVLYPVASMRHLELWVNYYIRWN
.||||||.||. . ||.|||.||||| ||| .|. .|..||| |||. . ..|... ||.|..| .  || |  .  .|.|| . | |..
kafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynrfd
subfamily_MTMR9_pd Subfamily MTMR9 167-549 3.9e-113 370.5 In-house 11-393 (393) alignment 
Range on Protein: 167-549
Range on HMM: 11-393/393.0
NVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEK
  ||.. ... .|. ..  . ..|||. .|| ...| .||. ..||   .|..|. .|.||.  |.||||..| |.|.|..|.||||.| |||| |.|||
ledgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedek

YLDVIRETNkqiSKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKV-KDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAI
 |... ...   .| .| | | .. | .... ||| | .. | . .    ........ .|| |. . .   ... ...|| ||.. ||.... .|. | 
llnlvlkkl...kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaal

QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNH-TDADRSPIFLQFIDCVWQMSKQFPTAFE
.||. ... ...|.|| ..| | | |.||||.|.||. .| ..||| |...|||  || ||||  .   .. ..  ..|.|| |.|||.|. .||| .||
vvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFE

FNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSN--KEKFKNPFYTKeINRVLYPVASMRHLELWVNYYIRWN
|||..||..  | ||..||||| ..|. |...|....|||||| .|..   ..| ||.| .  ..|. | .    |||| . |.||.
FneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylrwq
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 161-548 1e-110 362.3 In-house 6-404 (405) alignment 
Range on Protein: 161-548
Range on HMM: 6-404/405.0
LNEEKFNVDGWTVYNPVEEYRRQGLP-------NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPL
||...  .||| |||  .|| |  .        | .|..| ||| |..| .|.. |||  .| | || .. .|||. ||| |||  |. .. | ||||||
lnsstssidgwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqpl

VGMSGKRNKDDEKYLDVIRETNKqISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVK--------DIVYPNVEESHWL
||.   |  .|| |   .  .      | . |||| .||.|| | | |.|    | |. | |..| ||||.| ||.|.         |  . .  . .. 
vgierarcpedelycsslalsap.sktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfw

SSLESTHWLEHIKLVLTGAIQVADKVSSGKsSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNhtDADRSPIF
  .| | |. ||| .|  |   |. .  |. |.||||||||||| |.|||. ..|| .||.| ||..|..|||.||||||. |.||   |  . .|||||
gyieetgwishiksileaatfsaelilkgn.silvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgn..eeerspif

LQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYY
 ||.||..|. .|||  |||   .|..| | ..||..|||| |||  | ...|  .|.|.|| .| | .|| ||.|  .  . . |    | ||||   |
qqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwkacy

IRW
.| 
mrv
subfamily_MTMR3_pd Subfamily MTMR3 273-546 5e-109 358.0 In-house 167-440 (442) alignment 
Range on Protein: 273-546
Range on HMM: 167-440/442.0
ETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVS
.. ..  || | |||    |.||.| |||.|  . |.|.|. ||.. ||| .|.|..... ..    .||.|||.||.|.||...  .|. |..|...|.
slaeekkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavd

SGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLII
  . .||||||||||||.|...|| |.|| .||..|||..||..||..|||||| |.|||.. ..  .|.|.|||..|.| |...||||.||||| ||. 
kegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvk

ILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYI
.. | ||| |||||.|.| .||..||.|||.|.|||.........|  |... . ||.|. |.|.|.|| . |.
lvqhtysclfGtflansekereeekvkertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyl
subfamily_MTMR5_pd Subfamily MTMR5 290-546 9e-61 198.1 In-house 208-479 (483) alignment 
Range on Protein: 290-546
Range on HMM: 208-479/483.0
VNAVANKATGGGYESdDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVE----ES-HWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSD
. .. .|.   ...| .....||.  .....|  .. |.||.  .  |. .    ||  .|.|.|   ||. |. .|  .  |.| .   .|||||   |
LYvlgeksqlknvks.evdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEd

GWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHgDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGT
||| |||..||| |.||..||..|||..||.|||..|||.|. |  .  .... .  .|.||||.|||.|.|.|||.|||||. .| ..  |  |.|| |
GwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnq.tlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrt

FLFNCESARERQKV----------TERTVSLWSLINSNKEK---FKNPFYTKEINRVLYPVASMRHLELWvNYYI
||...|  |  . .           . ..|.|  |. ....   | |  |... . || | ... .|..| .||.
fllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvW.dyyl
subfamily_MTMR10_pd Subfamily MTMR10 330-550 5.6e-55 178.6 In-house 135-379 (380) alignment 
Range on Protein: 330-550
Range on HMM: 135-379/380.0
KVKDIVYPNVE------ESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGH
|.. .  ..        . .||||||.|.||. ..|.|  |..... | . | ||..  |.| |    . ||| ||||..||.|.||. |.||||.. ||
klreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaagh

KFASRIGHGDKNHTDADrsPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLW-SLINSNKEKFKNPFYT
.| .|.||.... .     |.|| | |||.|  .|||..|||.|.||| ..|. .|. |.|||||.|..|....|    . .  |  ..|.  . ...|.
pfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyr

KEIN-------------------RVLYPVASMRHLELWVNYYIRWNP
. ..                   ... |. ..  ..|| . |.|| |
qglyaeiiksirrlaaaksylrseiirPllqipdiqlWdeCYlRWvP
subfamily_MTMR3_pd Subfamily MTMR3 177-273 9e-30 96.8 In-house 30-127 (442) alignment 
Range on Protein: 177-273
Range on HMM: 30-127/442.0
VEEYRRQGL-PNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRE
 ||. |.|.  ...|||. .|. ..|| .||  |.||   .||||..||.||| .|.|.. | | .|..|..||||| ||. | ||..||| |. | .
keeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiak
subfamily_pats1_pd Subfamily pats1 442-523 1e-28 92.2 In-house 553-634 (691) alignment 
Range on Protein: 442-523
Range on HMM: 553-634/691.0
SPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTK
||||.||.| |||. |.||. |||||..|...... .| |||.||..    .  .|| .|. |.||.|| || .| | .| .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykh
subfamily_pats1_pd Subfamily pats1 309-436 1.7e-25 81.5 In-house 334-464 (691) alignment 
Range on Protein: 309-436
Range on HMM: 334-464/691.0
HNAELFFLDIHNIHVMRESLKKVKD-IVYPNVEESHWlSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQL---TSLAMLMLDSFY
  ... ||..   . ..|   .. . |.  .  .. | ...|  .|.. .||.| .|..|. ..  |.| .|   .|. . . .|   .|||....| ||
issniiflslPtrekveerffdllqsilsldgsddew.keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfy

RSIEGFEILVQKEWISFGHKFASRIGHGDKNH
|...|| .|..|||.|.|. |. .  | ....
rtldGfkvliekewlsyGfPfskinyhkesdd
subfamily_MTMR5_pd Subfamily MTMR5 177-256 2.2e-21 68.2 In-house 11-101 (483) alignment 
Range on Protein: 177-256
Range on HMM: 11-101/483.0
VEEYRRQGLPN-------HHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQP----LVGM
| .|.| || .        ..||. .|| |..|..||||.||| . ||| ..|||    .||.||  | |. ||....| ...    .||.
vqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgl
GRAM GRAM domain 41-103 7.3e-16 48.9 Pfam-A 6-68 (69) alignment 
Range on Protein: 41-103
Range on HMM: 6-68/69.0
AVPRLPGETLITDkeviYICPFNG---PIKGRVYITNYRLYLRSLETDSSL-ILDVPLGVISRIEKM
 .  .|.| |..|    | |....   | .||.|.|||||. ||  .|.|   ...||..|.|.||.
tfklppeEklldd....yaCylstskgpvqGrlYlTnyrliFrSdklddskvvvvipladikrveks
PTPc_DSPc_SM00012 335-477 2.3e-15 52.0 In-house 6-104 (105) alignment 
Range on Protein: 335-477
Range on HMM: 6-104/105.0
VYPNVEESHWLS-SLESTHWLEHIKLVLTGAIQvadkvssgKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSiegfeilvqkewisfghkfasrighgd
 |..  . .. . | . ...|...| . . . .        ...|.||||.|..||.... |..|. .  ...                           
hytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleket...........................

knhtdadrspIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHL
           .... ..|... || |......||.|...  .|
..........kevdifqivkelrkqRpgmvqteeqylflyrall
0045098 (Phosphotyrosine protein) phosphatases II 304-432 8.4e-13 43.8 In-house 127-274 (278) alignment 
Range on Protein: 304-432
Range on HMM: 127-274/278.0
SDDAYHNAELFFLDIHNIHVMRESL--KKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSS------GKSSVLVHCSDGWDRTAQLtSL
| . ...  | .| ..|..|.||.|   .|. . |..... .. |.  ....||... ..    ..|....|      ..  |||||| |..||. |  .
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl.va

AMLMLDS------------FYRSIEGFEILVQKEWISFGHKFASRIGHG
|.|||.             ..||  .....  .|.. | ..|. .. . 
aylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_pats1_pd Subfamily pats1 167-249 1.2e-11 35.8 In-house 2-83 (691) alignment 
Range on Protein: 167-249
Range on HMM: 2-83/691.0
NVDGWTVYNPVEEYRRQGLPNHH-WRITFINKcYELCDTYPALLVVPYRASDDDLRRVATFRsRNRIPVLSWIHPENKTVIVRC
. . . .| .. |..| .|   . ||.. . .  .|.. ||   .||   ||. |   .  | . .|||||| ...||....| 
tteifdiyslliegqrlkldldkdwrvvefls.rdlseiyPkrilvPklvsdellvsyvrkr.sskiPvlswsnqnnksslfri
subfamily_MTMR14_pd Subfamily MTMR14 373-433 1.1e-08 26.3 In-house 266-332 (357) alignment 
Range on Protein: 373-433
Range on HMM: 266-332/357.0
SGKSSVLVHCSDGWDRTAQLTSLAMLML--D-SFYRSIEGFEIL---VQKEWISFGHKFASRIGHGD
 ..| .||||  |||||   .||  | |  |   ..|..  |.|   |  .|  |||....|. .|.
dedsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkge
subfamily_MTMR10_pd Subfamily MTMR10 187-293 4.9e-08 24.1 In-house 23-129 (380) alignment 
Range on Protein: 187-293
Range on HMM: 23-129/380.0
NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKtVIVRCSQPLVgMSGKRNKDDEKYLDVIRETNK--QISKLTIY
.. .. .  |.  . . |.|  .||| . ||.|..|.       | |...| |.. . . .|.|.     . . ... || |  .|...   ..  . . 
sdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakga.allrlsalqe.aesadkekeekmlelvrkchpandvklvdls

DARPSVNAV
|  ||.. |
delpsiqdv
0049772 (Phosphotyrosine protein) phosphatases II 311-401 9.1e-08 27.7 In-house 156-238 (314) alignment 
Range on Protein: 311-401
Range on HMM: 156-238/314.0
AELFFLDIHNIHvmreslkkvkDIVYPNVEESHWLSSLESTHWLEHIKLVLTG---AIQVADKVsSGKSSVLVHCSDGWDRTAQLTSLAMLMLD
.|. . |. ...          ...|..   ...   .  ...  .    |     .... ... . .. |||||..|..||. .  .|.||. 
neptaadlellk..........eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkl
0051429 (Phosphotyrosine protein) phosphatases II 331-467 2.3e-07 26.3 In-house 83-212 (272) alignment 
Range on Protein: 331-467
Range on HMM: 83-212/272.0
VKDIVYP-------------------------NVEESHWLSSLESTHWLEHIKLV--LTGAIQVADKvssgKSSVLVHCSDGWDRTAQLTSLAMLMLDsf
    ..                          . .|....  |  | |. |      |  ....  .    .  |||||| |.|||. .  | .|.|.  
ptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllg..

yrsiegfeilvqkewisfghkfasrighgdknhtdadrspifLQ--------------FIDCVWQMSKQFPTAFEFNE
                                          .                 ..| .. .|.| |..  |
..........................................vsletivddYlltnlyleeaveelraqrpgavqtee
3-PAP Myotubularin-associated protein 511-570 2e-06 18.1 Pfam-A 57-120 (142) alignment 
Range on Protein: 511-570
Range on HMM: 57-120/142.0
SNKEKFKNPFYT--KEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPV--EQRYMELLAL
.. |..... ..   .....| |  . ..|.||  .| || |  ..    .|  .....|||  
taseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPeaeikgggqvqvdlklsellee
0044763 (Phosphotyrosine protein) phosphatases II 358-399 3.3e-06 22.4 In-house 92-134 (178) alignment 
Range on Protein: 358-399
Range on HMM: 92-134/178.0
KLVLTGAIQVADKVS-SGKSSVLVHCSDGWDRTAQLTSLAMLM
   .  ...  ...  . .. |||||| |..|.. |  . ...
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmk
0043336 (Phosphotyrosine protein) phosphatases II 351-399 5.2e-06 21.6 In-house 186-234 (278) alignment 
Range on Protein: 351-399
Range on HMM: 186-234/278.0
THWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLM
 .. |...|.|    .| ..... .. ||||||.| .||. .  | .|.
hgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialylll
DSPc_SM00195 323-472 7.5e-06 20.8 In-house 137-254 (263) alignment 
Range on Protein: 323-472
Range on HMM: 137-254/263.0
VMR-ESLKKVKDIVYPNVEESHWLSSLESTHWLEHiKLV--LTGAIQVADKVSSGKS----SVLVHCSDGWDRTAQLTSLAMlMLDSFYRSIEgfeilvq
 .. |  ...  . . . ||.. .  .. . | .| ..    .  ...  .| . ||     ..||||.| .||. . .. . .|... .  .       
kkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi.ilskleeekk.......

kewisfghkfasrighgdknhtdadrspifLQFIDCVWQMSKQFPTAFEFNEQFLII
                              ... ..| .. || | ...  ||.|.|
..............................vdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 323-472 7.5e-06 20.8 In-house 137-254 (263) alignment 
Range on Protein: 323-472
Range on HMM: 137-254/263.0
VMR-ESLKKVKDIVYPNVEESHWLSSLESTHWLEHiKLV--LTGAIQVADKVSSGKS----SVLVHCSDGWDRTAQLTSLAMlMLDSFYRSIEgfeilvq
 .. |  ...  . . . ||.. .  .. . | .| ..    .  ...  .| . ||     ..||||.| .||. . .. . .|... .  .       
kkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi.ilskleeekk.......

kewisfghkfasrighgdknhtdadrspifLQFIDCVWQMSKQFPTAFEFNEQFLII
                              ... ..| .. || | ...  ||.|.|
..............................vdifeivkelRkqRpgmvqtleqYlfi
0051082 (Phosphotyrosine protein) phosphatases II 358-401 9.5e-06 20.8 In-house 74-118 (151) alignment 
Range on Protein: 358-401
Range on HMM: 74-118/151.0
KLVLTGAIQVADKVSSG-KSSVLVHCSDGWDRTAQLTSLAMLMLD
 | .  .... ... .  .  |||||| |..||. |  | ...|.
plsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg
0043147 (Phosphotyrosine protein) phosphatases II 352-401 9.8e-06 20.9 In-house 76-125 (172) alignment 
Range on Protein: 352-401
Range on HMM: 76-125/172.0
HWLEhIKLVLTGAIQVADK--VSSGKSSVLVHCSDGWDRTAQLTSLAMLMlD
|.   .  .|  ...  |.  . | .  |||||| |..||. |  . ...  
hgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.l