Gene MTMR14 in Homo sapiens

Synonym: C3orf29, MTMR14

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP052_AA protein Get Run
HsapP052_AA_244-406 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 59-411 1.8e-179 588.1 In-house 1-356 (357) alignment 
Range on Protein: 59-411
Range on HMM: 1-356/357.0
KRCLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEY---ESSEKEKDTFESTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYG
|...||. |||..||| ||||..|..||.....|||   |.||.||...||...|..|..|....|.|||| |||.||||..||.|||||||. ..|.||
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiyg

RSGYNYFFSGGADDAWA--DVEDVTEEDCalRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCE
|||.||..|||......  |.|..|...   .. ...|.|.||..|||||..|.||.|.|||||.||||.|..|.||||.||..||.||||||.||||.|
rsGlnylasggeeadadkedeelitaked..qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPyPGve

FFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGL
|||...|..|.|. |..|||||.||| |.||| |..|..||||.|..||||..|||||||||..|..|.||||||||||||||||||.||||||||||||
ffkkfrdnkysaknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsllrlslWadgl

IHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQ
||.||...|.||||||||||||||.|.|||.|||||.||||..||.||||||| |.|.
ihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsiletr
0040695 (Phosphotyrosine protein) phosphatases II 53-431 1.7e-55 182.3 In-house 9-348 (388) alignment 
Range on Protein: 53-431
Range on HMM: 9-348/388.0
KVERIEKRCLEL-FGRDYCFSVIPNTNGDICGHYPRHIVfleyessekekdtfestVQVSKLQDLIHRSKMARCRGRFvcPVILF----KGKHICRSATL
 .  |....  | .|.|... .| | |...|..||...|                 |..|  ..|. |.   |..||.  ||...    .|....||...
slydilrelkrlglgldlwrisivNenyelcpsYPallv.................VPksisdellkrvarfrskgri..PvlsyrhpnngavllRssqp

AGwgelygrsgynyffsggaddawadvedvteedcALRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMvenKKVKFGMNVTSSEKVDKAQRYADFTLLSI
 .                                  |  .. . ..|......|||. ||. .|.||.   .|... .|......|.. ..|....|...
lv.................................glllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaelifl

PYPGCEFFKEykdrdymaeglifnWKQDYVDAPLSIPDFLthSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRLS
..|......|              . |...|| |..||.|  .|.. ..... .||.........|...|.. ...|..||||..|||||....||..|.
nipnihvvre..............slqklldaclnvpdsl..nllslleesgwldliklilelavlivklld.lgnssvlvhcsdgwdrtsqlssLaqll

LWADgliHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE---------------------------IFFFCFNFLKHITSEEFSAL--------KTQR
|...   . .|.   .|   ....|..|||.. |||. .|.                           .|.|....|.... . .| .        ...|
ldPy...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnseker

RKSlPARDGGFTLEDICML
...   .. ...| .... 
lel.svsertlslwsylls
0051082 (Phosphotyrosine protein) phosphatases II 198-347 2.7e-09 32.3 In-house 24-116 (151) alignment 
Range on Protein: 198-347
Range on HMM: 24-116/151.0
YDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEkvdkaqryadftllsipypgceffkeykdrdymaeglifnwkqdyvdaplsipdflthslnIDWSQ
 ...||. | .|.|..|. |    ..   ... .                                                             |.. .
dflellkelgiktivnlrseeergycpeylpelg.............................................................ievlh

YQCWDLV----QQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLS
....|      ..... .. .|.|......  .|||| .|..|| ... |... 
ipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml
0051429 (Phosphotyrosine protein) phosphatases II 199-351 5.5e-09 31.6 In-house 37-178 (272) alignment 
Range on Protein: 199-351
Range on HMM: 37-178/272.0
DIKLLRYLSVKYICDLMVENKKVKFGMNVTSsekvdkaqryADFTLLSIPYPGCEFFKEYkDRDYMAEGLIFNWKQDYVDAPLSIPD--FLTHSLNIDWS
|.. |. | .|.|.||. |. . ...               .....| .|... ...      ...   | . .. ||.   | .      . .. . . 
dfwrlkelgiktivdLrseeErgrlkcdryw..........pgirylhlpilddsaptil.ygalrvtllseellldyilrellltlllsagearevmhl

QYQCWDLVQQTQNYLKLLLSLVNSddDSGLLVHCISGWDRTPLFISLLRLSLWAD
.|. |      |..|. ||.|...  .  .|||| .|.||| ... ||.| |  .
hytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvs
subfamily_MTMR3_pd Subfamily MTMR3 311-388 7e-09 27.9 In-house 255-328 (442) alignment 
Range on Protein: 311-388
Range on HMM: 255-328/442.0
LKLLLSLVNS--DDDSGLLVHCISGWDRTPLFISLLRLSLwaDGLiHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
||  ...|..   .   .||||  |||||.  ..| .| |  |   . .|.  ..|   |  .|. ||| . || . ||.
lkaavkvveavdkegrpvlvhCsdGWdrttqivalaklll..dpy.yrtleGfkvl...vereWldfGhkfadrcghgen
0049772 (Phosphotyrosine protein) phosphatases II 262-349 1.1e-08 30.7 In-house 156-240 (314) alignment 
Range on Protein: 262-349
Range on HMM: 156-240/314.0
DYMAEGLIFNWKqDYVDAPLSIPDFLTHSLNIDWSQyQCWDLVQQTQNYLKLLLSLvnsDDDSGLLVHCISGWDRTP--LFISLLRLSLW
..  .  . ..| . .. |   ..   . |.|...   ...| .. .  |......   |... .|||| .|..||.  ... .| . |.
neptaadlellk.eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg
0042113 (Phosphotyrosine protein) phosphatases II 284-346 4.2e-08 28.4 In-house 137-199 (245) alignment 
Range on Protein: 284-346
Range on HMM: 137-199/245.0
PDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
. . .| . ..|  ... ||... .. |..... ...|..  .||||  | .|| .|| ....
srevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
0036282 (Phosphotyrosine protein) phosphatases II 283-346 5.2e-08 28.3 In-house 65-127 (174) alignment 
Range on Protein: 283-346
Range on HMM: 65-127/174.0
IPDFLTHSLNIDWSQYQCWDLVQqTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
  ..  . | . |  ... || .  .. .|.. . ...|..  .||||  | .||.... ....
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylm
0044763 (Phosphotyrosine protein) phosphatases II 199-343 6.6e-08 27.9 In-house 40-130 (178) alignment 
Range on Protein: 199-343
Range on HMM: 40-130/178.0
DIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDkaqryadftllsipypgceffkeykdrdymaeglifnwkqdyvdaplsipdflTHSLNIDWSQY
|..||. | ...|..|  |    .....    |. .                                                      . |.| .. .
dlellkelgithivnlteelelgflkcdpywpeeag.....................................................iqylhipipDh

QCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISL
 . || ..... .... .... ....  ||||  |..|..... .
gvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaa
subfamily_MTMR1_pd Subfamily MTMR1 324-388 1.4e-07 23.1 In-house 213-271 (389) alignment 
Range on Protein: 324-388
Range on HMM: 213-271/389.0
SGLLVHCISGWDRTPLFISLLRLSLwaDGLIHTsLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
.  ||||  |||||  ..||  | |  |    | ..  |.|   .. .|  ||| . .||..|..
tsvlvhcsdGWDRtaqltsLamlll..DsyyRt.ieGfevl...iekeWlsfGHkfkeRlghgdk
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 314-385 1.7e-07 22.8 In-house 214-278 (404) alignment 
Range on Protein: 314-385
Range on HMM: 214-278/404.0
LLSLVNSDdDSGLLVHCISGWDRTPLFISLLrlSLWADGLIHTslkpTEILYLTVAYDWFLFGHMLVDRLSK
...|....  |  ||||. |||||.   ||    | .|    |     |  .  .  .|  |||. ..| ..
ivelieke.kssvlvhcsdgwDrtsqlssls..qllldpyyrt....iegFivliekewlsfGhkfaqRigq
0048179 (Phosphotyrosine protein) phosphatases II 267-346 2.2e-07 26.3 In-house 48-106 (144) alignment 
Range on Protein: 267-346
Range on HMM: 48-106/144.0
GlifnwkqdyvdaplsipdfLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsdDDSGLLVHCISGWDRTPLFISLLRL
                     .. |...|  ... || .. .. |... ....  ..   ||||  | .||.... . ..
e...................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylm
0043147 (Phosphotyrosine protein) phosphatases II 281-344 3.7e-07 25.5 In-house 59-121 (172) alignment 
Range on Protein: 281-344
Range on HMM: 59-121/172.0
LSIPDFLTHSLNIDWSQYQCWdLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLL
    ..  . | . |  . .  | .. .. |... .|.. ...   ||||  |..||.... ..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay
0040439 (Phosphotyrosine protein) phosphatases II 288-346 3.9e-07 25.4 In-house 143-202 (249) alignment 
Range on Protein: 288-346
Range on HMM: 143-202/249.0
THSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
.|   .||  ... . .... ........ .... ... .||||  | .||..|| .. .
lhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0048076 (Phosphotyrosine protein) phosphatases II 285-345 4.9e-07 25.1 In-house 45-103 (145) alignment 
Range on Protein: 285-345
Range on HMM: 45-103/145.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDddSGLLVHCISGWDRTPLFISLLR
.. .. |...|  ... || .. .. |... ......     ||||  | .||.... .  
rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaayl
0037934 (Phosphotyrosine protein) phosphatases II 285-349 5.2e-07 25.0 In-house 133-204 (243) alignment 
Range on Protein: 285-349
Range on HMM: 133-204/243.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNS-------DDDSGLLVHCISGWDRTPLFISLLRLSLW
 . .| . . |  ... | ... ...|. . . ...       |... .||||  | .|| ..| .. . | 
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll
0043336 (Phosphotyrosine protein) phosphatases II 283-346 5.6e-07 24.8 In-house 171-233 (278) alignment 
Range on Protein: 283-346
Range on HMM: 171-233/278.0
IPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRL
 . . ||   ..|  ... . ... ...|| ... .. |... .||||  | .|| .|| |..|
esrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll
0045098 (Phosphotyrosine protein) phosphatases II 203-346 6.7e-07 24.5 In-house 84-229 (278) alignment 
Range on Protein: 203-346
Range on HMM: 84-229/278.0
LRYLSVKYICDLM--VENKKVKFGMNVTSsekvDKAQRYADftlLSIPYPGCEFFKEYKDRDYMAEGL----IFNWKQDYVDAPL-SIPDFLTHSLNIDW
|. | ...|. |.  ||....|. .   .    .. ..| |   ... .  .| ...|  |... . |      . .       . ..||. ..||.| .
lwelgitvivmltelvelgrekcaqywpe....ggsltygd...ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

SQYQCWDLVQQTQN--YLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
|  .... ... ..  . .||.||.  |..   ||||  |..||  .. .  .
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm
0049260 (Phosphotyrosine protein) phosphatases II 259-345 1.1e-06 24.0 In-house 55-111 (152) alignment 
Range on Protein: 259-345
Range on HMM: 55-111/152.0
KdrdymaeglifnwkqdyvdaplsipdfltHSLNIDWSQYQCWDLVQQTQNYLKLLLSLvNSDDDSGLLVHCISGWDRTPLFISLLR
                              . |.. |  . ..|| |  .  |...  | . |..   ||||  | .||.... .. 
i.............................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaayl
0039614 (Phosphotyrosine protein) phosphatases II 285-346 1.2e-06 23.7 In-house 183-245 (297) alignment 
Range on Protein: 285-346
Range on HMM: 183-245/297.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
 ..|| . ..|  ... ..... .. |.|. . .... ..   ||||  | .||  || ....
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm
Myotub-related Myotubularin-like phosphatase domain 314-386 1.9e-06 19.9 Pfam-A 220-288 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 314-386 1.9e-06 19.9 In-house 220-288 (353) alignment
0045450 (Phosphotyrosine protein) phosphatases II 285-346 2.7e-06 22.8 In-house 195-257 (307) alignment 
Range on Protein: 285-346
Range on HMM: 195-257/307.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
 ..||   ..|  ... . .... . ...... .... ...  ||||  | .||. || .. .
rtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0046846 (Phosphotyrosine protein) phosphatases II 263-346 3.6e-06 22.4 In-house 77-132 (176) alignment 
Range on Protein: 263-346
Range on HMM: 77-132/176.0
YmaeglifnwkqdyvdaplsipdfltHSLNIDWSQYQCWDLvQQTQNYLKLLLSLVNSDddSGLLVHCISGWDRTPLFISLLRL
.                         . |...|  ... || .. .. |... . ....     ||||  |  ||.... .. |
i.........................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayll
0040438 (Phosphotyrosine protein) phosphatases II 286-346 9.2e-06 20.6 In-house 173-232 (317) alignment 
Range on Protein: 286-346
Range on HMM: 173-232/317.0
FLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRL
..||   ..|  . . .  .. .. |... .  . |... .||||  | .||  || ....
tvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylm