Gene SBF2 in Homo sapiens

Synonym: CMT4B2, DENND7B, MTMR13, SBF2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP056_AA protein Get Run
HsapP056_AA_1105-1628 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR5_pd Subfamily MTMR5 1106-1620 2.7e-224 737.4 In-house 2-483 (483) alignment 
Range on Protein: 1106-1620
Range on HMM: 2-483/483.0
MEQLVEKACFRDYQRLGLGTISGSssrSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGV
.|.|.|.|...||.|||||...|.   |. ..|||...|..|..|||||.|.|||..|.|.|. |||.|.|.||||||.|...|...||.|||||..|||
veklaerayvqdykRlGlgalnga...skrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgv

VGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGTERRTSRMSTVlkqvvPGHLDVNPSNSFAQGGVWASLRss
|||.||.|........| |||.|.||||||.|..|.||....|..||.|.|......|. ........||.      ..||.. |....||| .|.|.  
vgllksantqgsstsessessksleqekylkavvnevsklsalalnsslevslsvlasssssdkraalste.....knaldisksdkasqggkgatlk..

trlissptsfidvgarlagkdhsasfSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVT-
                          .|... ...| .|.||||..||||||.|.|.|.. ..||.|||..||||||||||||.|||.|||  ...|.. 
..........................ennakeskklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqs

FLKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPV
|||...||||. |.....||...|...|. .||||||.||.|||.||||.||.|||.||.|||||||..|||||||.|||.|..||..||..|.||||||
FlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPv

FLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKK-GVCIWECIDRMHKRSPIFFNYLYSPLEIEALKP
|||||||||||..|.|..|||| .||||||.|.|||||.||||||.|||||.|.|...|.||.||| |...|..|||.|||||||.|.|||| | |.|.|
FlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynflyspdesevlrP

NVNVSSLKKWDYYIEETL
..|||||| ||||.||.|
ssnvsslkvWdyyleeel
0040695 (Phosphotyrosine protein) phosphatases II 1104-1620 9.1e-113 370.7 In-house 3-386 (388) alignment 
Range on Protein: 1104-1620
Range on HMM: 3-386/388.0
STMEQLVEKACFRDYQRLGLGTisgsssrsrpEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGk
 ..|  .. ...|...|||||.          ...||.  |..|.||.|||.|||||. ..|. | ||||.....|.||........| .||||. ... 
lleegwslydilrelkrlglgl..........dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv.

gvvglfksqnspqaaptsSLESSSSIEQEKYLQALLNAVSvhqklrgnstltvrpafalspgterrtsrmstvlkqvvpghldvnpsnsfaqggvwaslr
                  .|  |.|.|.||.|.|.|.. .                                                            
..................glllsrsledeklleailkllp............................................................

sstrlissptsfidvgarlagkdhsasfSNSSYLQNQLLKRQAALYIFGEKSQLRNfkVEFALNCEFVPVEFHEIRQVKASFKKLMRACipstIPTDSEV
                            ..| .|   | ..  ||.    ... .|   ..  |.|........|..|..|..||..||    ...... 
............................nlskllivdlrpklnalanralgggven..edaypnaeliflnipnihvvreslqklldac....lnvpdsl

TFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSS-VLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTL-NCQGSGFA
 .|..|..|.|. ....|..|||.. . |..|.| |||. ..|||.|.|..||.||| ||.||||||||.|.|||||||||||..|....  ... ..|.
nllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefs

PVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTlfddkgekhAKKGVCIWECIDRMHKRspiFFNYLYSPLEIEALK
||||.|||||.|...|.||.|||| ..|.||| |..|.||.|||..|..||||...          ......|... .....   |.|.||.| . | |.
PvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv.........sertlslwsyllsrkse...flnplYdpsslevll

PNVNVSSLKKWDYYIEETL
|...|..|..|..|  ..|
pslsvldlllWleyylrwl
SBF2 Myotubularin protein 528-754 5.9e-109 351.9 Pfam-A 1-225 (225) alignment 
Range on Protein: 528-754
Range on HMM: 1-225/225.0
PAGPPVVSIMDKVTTVF-NSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLE
||||.|.||..| .... |||.||||.|||||.||.|||||..|.|||.|||||.||||..|..|| .|||||||.|||||||...|.||..|||.|. .
pagptvasivektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakd

EYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSakeDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPT
||..|||||||.|||.|||..||||||||||||||.|.||||||.|||. ||.....|||.   .... . |.|..  . . .||.|...||.|||.|||
eygvaaallplssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelyle...kkseskkkkktesslskkeeksaleiaadqlrkwpt

LSKSTQQELVQHEESTVFSQAIHFANLM
|||..|.|||..|||||.||||||||..
lskekqkelvkkeestvysqaihfanrl
Myotub-related Myotubularin-like phosphatase domain 1101-1554 5.6e-99 324.2 Pfam-A 13-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1101-1554 5.6e-99 324.2 In-house 13-352 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 1364-1616 1.5e-62 204.1 In-house 144-384 (389) alignment 
Range on Protein: 1364-1616
Range on HMM: 144-384/389.0
FALNCEFVPVEFHEIRQVKASFKKLMRACIPSTiptdSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDP
.  |.|.. .. |.|. |..|.|||  ...|..    ..  .|.|| ...|. ... |.. || . | .|.  .||||. ..||| |||.||| .|| |.
aYknaelifldihnihvvReslkklkelvlpnv....ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDs

FYRTLEGFQMLVEKEWLSFGHKFSQRSSL-TLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEhgtlfdd
.|||.|||..|.|||||||||||..| .    | . .  .||||||.|||.|...|.|| ||||  .| .|. |. | .| |||..|. || .       
yyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervk.......

kgEKHAKKGVCIWECIDRMHKrspIFFNYLYSPL-EIEALKPNVNVSSLKKWD-YYI
  ||  .| | .|  .. ...    |.| ||..  | ..| |.. ...|. |  ||.
..ekvkektvslwsyvnsske...eftnplyaeelekkvlypkaslrrlelWkeyyl
DENN DENN (AEX-3) domain 117-297 1.6e-60 193.5 Pfam-A 2-184 (185) alignment 
Range on Protein: 117-297
Range on HMM: 2-184/185.0
APKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCAC-LVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLF
.||.|...||| . |.|. .|  ..... .| ...|||.||||...  .||.| ..||.||.. ...|.|.| ...||......  ||..|.|.|||.||
ipkalcilsrlpffelfkkiLkalekrlksssklplesfianlllevplPapgktlklkslsvkekillqrpssselPledvdleelfrcLsienvlqlf

CAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKT-DVHELLDVIIADLDG
.|||.|......| ...||.....|| .|..|||....|||.|||.||.||..||||||||.| ... . ..| ||...||| 
eavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldt
subfamily_MTMR3_pd Subfamily MTMR3 1363-1613 1.3e-56 185.2 In-house 200-436 (442) alignment 
Range on Protein: 1363-1613
Range on HMM: 200-436/442.0
EFALNCEFVPVEFHEIRQVKASFKKLMRACIpstiPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSD
|.  ||| | ...  |  |. ||..|   .      .  | ..| ||   .|. .|  ... || |.| ... | .|||   .||| |.|...| .|| |
eyypncevvflglanihavrksfnslralls....qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllld

PFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEhgtlfd
|.|||||||..|||.|||.|||||. |..   | .     .|||||.||.|||...|.|| ||||  .|  |. |  |  | ||| .|  || |      
pyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree......

dkgEKHAKKGVCIWECIDRMHKRspiFFNYLYSPLEIEALKPNVNVSSLKKWD
   ||  .. . .|...   .|.   . | ||.. .   | |.|.| .|| | 
...ekvkertlsvWsllrakeke...yrnllykekteavllpavsvrelklws
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1363-1598 2e-54 177.3 In-house 152-373 (404) alignment 
Range on Protein: 1363-1598
Range on HMM: 152-373/404.0
EFALNCEFVPVEFHEIRQVKASFKKLMRACiPSTIptDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSD
.   |||      ..| ... |.|||  |.  |.|  ..|  .|. | .|.|. ....... .  ..|..| ..|||||   .||| |.|..||.||| |
sryenceieflnienihelreslkklkkav.nsii..ekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllld

PFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLehgtlfdd
|.|||.|||..|.||||||||||| ||.. | . . . ..|.||||.|||.|. .|.||.||||  .|. .  .  |.||.||| ||. ||         
pyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq........

kGEKHAKKGVCIWECIDRMHkrsPIFFNYLYSPLEIE
  .. ||. | .|  ..  .     ..| ||   . |
.qnnlaketvslWalleank...seylnplyilekke
subfamily_MTMR6_pd Subfamily MTMR6 1363-1613 2.2e-51 167.4 In-house 153-389 (397) alignment 
Range on Protein: 1363-1613
Range on HMM: 153-389/397.0
EFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTiptDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVL-ENGSSVLVCLEEGWDITAQVTSLVQLLSD
..  |..|  |. ..|  ...| .||. ..  ..    | . ||..| .|.|.  .. ... ...... . |.| ||||   .||| ||||.|| .|| |
dnysnikfqfvgienihvmreslqkllevvelks...ksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllld

PFYRTLEGFQMLVEKEWLSFGHKFSQRSSlTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHgtlfdd
|.|||..||..|.||||||||||||.|.  .|. ..  ..|.|.|||.|| |. .|.|. ||||  .|  |  |  | .| ||| ... .| ..      
pyyrtikGflvliekewlsfGhkfsercG.lldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdl......

kgeKHAKKGVCIWECidrMHKRSPIFFNYLYSPLEI-EALKPNVNVSSLKKWD
   | ...   .|     ...|   . | ||.. .  |.|||......|| | 
...klkertkslway...llerkddylnplykaetekevlkpdtapaalklwr
subfamily_MTMR9_pd Subfamily MTMR9 1375-1613 1.2e-49 161.5 In-house 159-386 (393) alignment 
Range on Protein: 1375-1613
Range on HMM: 159-386/393.0
FHEIRQVKASFKKLMRACIPSTIPTDSevtFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQML
 ....... |. ||. ||   .. ||.   ||. |  | |. |.. ....|.||...|.. |..|.|  ||| |.| |||||.||. || .||..||. |
lesvasiqdslaklleacsdaglstdk...flsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfeal

VEKEWLSFGHKFSQRSSLTLNCQ--GSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTlfddkgekhAKKGV
.|.||.  || |..| | .  ..      .|||| |||||.|. .|.| .||||  .| .|  |  | .| ||| |.. || |..           || |
iereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelkl.........kkktv

CIWECIdRMHKRSPIFFNYLYSPlEIEALKPNVNVSSLKKWD
..|. .   ... . |.| ||.. . | . |.|.  ||. |.
slwsyv.nrpeklkqflnplyea.naeviwpsvapqslelWs
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1366-1613 5.8e-43 139.2 In-house 160-398 (405) alignment 
Range on Protein: 1366-1613
Range on HMM: 160-398/405.0
LNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDS----EVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSD
 || .| ..  .|  .. |..||. |   |.   |     .. |   . .. |  ... |.. | . .|.. .| |.||   .||| | |.||| |.| |
pncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaelilkgnsilvhcsdgwdrtpqitsltqilld

PFYRTLEGFQMLVEKEWLSFGHKFSQRSSlTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEhgtlfdd
|.|||. |||.|.|||||||||||| |    |  .    .|.| |||||. |. .|.|  |||    | |..    | .. ||| . . .|..       
pyyrtivgfqvliekewlsfghkfslrlg.hlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq.......

kgEKHAKKGVCIWECIDRMHKRspiFFNYLYSPLEIEALKPNVNVSSLKKWD
  ..   | . ||  ..   ..   |.|  | | .|...||..    |. | 
..dqvktktisiwsevnlnvnk...flnpyynpqdiqsikpklysrclelwk
subfamily_MTMR10_pd Subfamily MTMR10 1375-1555 5.8e-42 135.8 In-house 123-305 (380) alignment 
Range on Protein: 1375-1555
Range on HMM: 123-305/380.0
FHEIRQVKASFKKLMRACIPSTIP--TDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVL-ENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQ
   |..|.....||.. |...|.    . .  .| .|  ..|    . ....|. ..... |.. ||..  .|| |.   | ||.||..||.|||..|||
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

MLVEKEWLSFGHKFSQRSSLTLNCQGSGFaPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEH
 |..||| . ||.| .|   . . ..|   |||| |||||.| ..|.|.||||.  .|  |  . .|  |.|||..|. .||..
sliqkewvaaghpfldrlghikpsekses.pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka
uDENN uDENN domain 25-86 5.9e-25 76.5 Pfam-A 2-65 (65) alignment 
Range on Protein: 25-86
Range on HMM: 2-65/65.0
GKIIQRFPQKDW-DDTPFPQGIELFCQPGGWQLSRER-KQPTFFVVVLTDIDSDRHYCSCLTFY
.||...||.||. .|.|.|. |..||.| |... ..| ..|.||. ||||.|. |.|..||.|.
pkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrfl
subfamily_pats1_pd Subfamily pats1 1375-1489 2.6e-21 67.7 In-house 343-457 (691) alignment 
Range on Protein: 1375-1489
Range on HMM: 343-457/691.0
FHEIRQVKASFKKLMRACIPstipTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCL-EEGWDITAQV---TSLVQLLSDPFYRTLEGF
.    .|.. | .|... .      |.     | . .| |   .  ... || ||  |..|||||.    .. .|. ..   .|| |.|||||||||.||
lPtrekveerffdllqsils....ldgsddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGf

QMLVEKEWLSFGHKFSQRS
..|.||||||.|. ||...
kvliekewlsyGfPfskin
dDENN dDENN domain 351-420 1.3e-19 59.3 Pfam-A 1-68 (68) alignment 
Range on Protein: 351-420
Range on HMM: 1-68/68.0
LDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEpvIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER
||..||..|||.||.|..|||..|. .| . |  ..|.| ||| .|   ...||...|. ..|| |..||
ldqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlksrskshrsFlsqfletqmFaeFieer
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1114-1235 1e-15 49.8 In-house 21-129 (404) alignment 
Range on Protein: 1114-1235
Range on HMM: 21-129/404.0
CFRDYQRLGLGTISgsssrsrpeYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGgfhgKGVVGLFKSQN
. ..|.|||. . |          .||.  |  |.|| .|| |||||. ..|. | .||    ..|.||..|..  ... . ||     . .||| ||. 
aeeEykRlgikses.........eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRss....qplvGltksrs

SPQAAPTSSLESSSSIEQEKYL
. .     |....... .. |.
eedEklinsirkaktqletlyi
subfamily_MTMR9_pd Subfamily MTMR9 1134-1198 3.8e-15 47.9 In-house 30-94 (393) alignment 
Range on Protein: 1134-1198
Range on HMM: 30-94/393.0
RPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARcYRHN-RLPVVCWKNSRSGTLLLRSG
  . .||.  |. ...| |||  ..||.|..| .|  .|. .|.. |.|| .. ... .. ||||.
asdewRissvNknfkvcasypesvivPkaiddeelkasaa.freggrfPvLsylhketkavllrss
PH PH domain 1779-1879 1.9e-14 44.0 Pfam-A 4-104 (104) alignment 
Range on Protein: 1779-1879
Range on HMM: 4-104/104.0
EGTLYKRGALLKGWKPRWFVLDVtkHQLRYYDSGE---DTSCKGHIDLAEVEMVIPAGPSMGapKHTSDKAFFDLKTSKR-VYNFCAQDGQSAQQWMDKI
||.|.|.. ||| ||.|.|||    ..| |..| .   . . || |.| ...  .   .  |  . ....  | ... ..  | ..| . .....|....
eGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndctvkkasstkfg..aqkesnnyfeitfknvesyllsaeseeerkrWvqal

QSCIS
....|
knlls
subfamily_MTMR1_pd Subfamily MTMR1 1137-1198 3.2e-14 45.0 In-house 26-87 (389) alignment 
Range on Protein: 1137-1198
Range on HMM: 26-87/389.0
YFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSG
 .|||  |. |.|| .|| .||||..|.|. | .||. . ..||||..| | .... .||. 
lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilras
subfamily_MTMR3_pd Subfamily MTMR3 1134-1198 6.4e-14 44.5 In-house 40-104 (442) alignment 
Range on Protein: 1134-1198
Range on HMM: 40-104/442.0
RPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSG
  | .||.  |  . ||.|||  |.||. ..|..| .||.    .|||.| |.  ..|..| |..
lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_pats1_pd Subfamily pats1 1498-1557 6e-13 40.0 In-house 550-609 (691) alignment 
Range on Protein: 1498-1557
Range on HMM: 550-609/691.0
SGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGT
 .|.|.|.|||| | |.. ..|. |||| ..|  |  .  | || .|| .   .. |.  
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkv
GRAM GRAM domain 872-957 6.2e-12 36.3 Pfam-A 2-69 (69) alignment 
Range on Protein: 872-957
Range on HMM: 2-69/69.0
KILRPALLPGEEIVCEGLRVLLDPDgreeatggllggpqLLPAEGALFLTTYRILFRGTPHDQLVgeqtVVRSFPIASITKEKKIT
|. ..  ||.|| . . ... | ..              ..|..|.|.||.||. ||. . |...    ||...|.|.|.. .|.|
kfrktfklppeEkllddyaCylsts..............kgpvqGrlYlTnyrliFrSdklddsk....vvvvipladikrvekst
PH_11 Pleckstrin homology domain 1779-1833 1.5e-07 21.5 Pfam-A 2-64 (112) alignment 
Range on Protein: 1779-1833
Range on HMM: 2-64/112.0
EGTLYKRGAL-LKGWKPRWFVLDVtKHQLRYYDSgedtscK--------------GHIDLAEVEMVIPAG
.| |.| |.  ||||| |||.|     .|.||.|                       |  ..........
kGylkkkgskllkgWkrrwfiLrk.dnvleYyks......prdksdvalitkesekvilkkdlsisnrls
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1116-1197 1.6e-07 22.5 In-house 23-101 (405) alignment 
Range on Protein: 1116-1197
Range on HMM: 23-101/405.0
RDYQRLglgTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS
..| |.    | . .  |   |...|. |. | .| ||.  ||| .   |  | ..     . |.| . ||.  | . . | 
keylrf...niyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrc
PH_3 PH domain 1767-1877 2.3e-07 19.4 Pfam-A 5-98 (104) alignment 
Range on Protein: 1767-1877
Range on HMM: 5-98/104.0
QYTSKnDENRSFEGTLYKRGALLkgWKPRWFVLDVTkHQLRYYDSGEdTSCKGHIDLAevemvipagPSMGApkHTSDKAFFDLKTSKRVYNFCAQDGqS
..... .|     |...||  |.   . |...|  .  .| | |  . ...||.| |           .. .  .....  | ..| ||.|..  ...  
rflee.gelilkqglvkKrkglf..arkRqlllteg.PrLiyvDpek.melkGeIpls.........kelkv..evknskkFfihtpkrtyyledpes.n

AQQWMDKIQSC
|..|...|.. 
aakWvkaieev
PH_8 Pleckstrin homology domain 1784-1875 4.6e-07 19.6 Pfam-A 6-86 (89) alignment 
Range on Protein: 1784-1875
Range on HMM: 6-86/89.0
KRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVemVIPAgpsmgapkhTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQ
||   |.|.. |.||||... .| || . .... .|.| | .   .| |          ..|  . ...  .|..  |.. . .|.|.. ..
krrkklqgyakRfFvLdlksstlsYyrddnssalrgkiplsla..iisa.........neekreiiidsGaevWeLkasnekdfqeWveale
subfamily_MTMR10_pd Subfamily MTMR10 1138-1197 2.3e-06 18.6 In-house 26-85 (380) alignment 
Range on Protein: 1138-1197
Range on HMM: 26-85/380.0
FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS
.. .  | .   . ..|  .|||. ..|| . |. | |.  | |. .|. ... .||. |
ivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrls