Gene MTMR8 in Homo sapiens

Synonym: RP11-284B18.5, MTMR8

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP059_AA protein Get Run
HsapP059_AA_125-507 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR6_pd Subfamily MTMR6 109-505 5.4e-223 732.4 In-house 1-397 (397) alignment 
Range on Protein: 109-505
Range on HMM: 1-397/397.0
LYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQP
||||||.||..||...|||||.|  ....|||.||..||.||.|..||.|.||| |..||||.|  ..|||||||||.|.||||||.|||.|||||||||
lyafsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp

LSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSG
||||..||..|| |||||...|| |...|||||||||||.||.||||||||||||.||.|.|.|||||||||.||||||||.|||....|||||||||||
lsgfsarcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessg

WLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQ
||.||||..||.|||.|||. |.|||||||||||||||||||.||.||||.|||.||...||||||.|.|||||.|||.||.|||||||||||||.|.||
wlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwq

LMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDK
|.||||.||||||.||||.||||.|||||.|||||.|||.||.. |.|.|.|..|..|| |. |||||  |...||.|.|.|.....|...||||||
lleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynrfdk
0040695 (Phosphotyrosine protein) phosphatases II 122-504 8.1e-152 499.2 In-house 3-386 (388) alignment 
Range on Protein: 122-504
Range on HMM: 3-386/388.0
MRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFY-TRCVDDE
..| || |.|.. .. |.|.... | |.. |.|||.|..||. .|||||..  ... ...|||| |.||||| ...|.|...|.||||.|.. .|...||
lleegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrslede

LLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCeLKTPTMSEFLSGLESSGWLRHIKAIMDAG
 ||||| ...|.......||.||||||.||||.|.|.||||.|.|... |..|.||||.|.||||||..| |..|.....|| ||.|||| .|| |... 
klleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilela

IFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDG--DSKEVSPIFTQFLDCIWQLMEQFPCAFE
..|.| .. .. |||||||||||||.|..| | .||||.|||..|...||||||.|.||||..|.|||..  ||||.||.| .||||.|||. |||.|||
vlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFe

FNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYgVLNPSTVPYNIQFWCGMYNRFD
|||..|| ..||..||.||.||.|..|.| .|.|.|.|.|.| .|..|| .|.||||. .... || ||. ......|...|.|..
FnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpssle.vllpslsvldlllWleyylrwl
Myotub-related Myotubularin-like phosphatase domain 108-449 1.7e-146 480.5 Pfam-A 1-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 108-449 1.7e-146 480.5 In-house 1-352 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 123-504 2.8e-140 460.0 In-house 3-387 (389) alignment 
Range on Protein: 123-504
Range on HMM: 3-387/389.0
RESGWKLIDPISDFGRMGIPNR-NWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYT-RCVDDE
.| |||. || ... |.|..|  .| ||. |..||.| |||. .||||.|.  .. ....||||.|.||||.| |||.|.| |.||||.|    |. .||
kedGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskede

LLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTpTMSEFLSGLESSGWLRHIKAIMDAG
 .|.|| ..|  |. ....| |.. ||.||.| |||||.|..| |... |. |.||||.| ||.|| |..  ..   ...|| |||. || |||.|... 
kylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnv.ddkkwlsalestkWlehiklilaga

IFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLD--GDSKEVSPIFTQFLDCIWQLMEQFPCAFE
. | ..|..||.|||||||||||||||. |.| .|||..||| .|. .||||||.|.||||..| || |     .| ||.| ||.||.|||..|||.|||
vkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFe

FNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFD
|||.||. . ||. || ||.|| |..| |.. .|.||| |.| .. ..| .|.||||.  .   ||.| .   ... |   | |..
fneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 110-502 1.1e-134 441.7 In-house 1-401 (404) alignment 
Range on Protein: 110-502
Range on HMM: 1-401/404.0
YAFSYNPKSSKEMreSGWKLIDPISDFGRMGIPNR-NWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQP
.||||..| |.    .||.. |..... |.||..  .| |...| .||.|.|||  .|||.|..   .. ...||||.|.||||.  ...|. | |.|||
fafsysekksvle..dgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqp

LSGF-YTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESS
| |   .|. .||.|...|..... .. .|..|.|||.||.||.| |.|||. ..| |   .|..||||| .| ||.|| ....  .   ...|| ||||
lvGltksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlseless

GWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGH-LDGDSKEVSPIFTQFLDCI
.|| ||| .. .   | . .. || |||||||||||||.|..|.. .||||.|||..| ..||||||.|.|||| ||.|.    .|.| |||| ||.||.
rWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcv

WQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLY--KGFTMYGVLNPST-----VPYNIQFWCGM
.||..|||  |||||.||..| |.. ||.||.|| ...|.|.. .....| |.|  | . | .. ||||  .    .   . |.      . .|..|  .
yqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWsey

YNR
| |
ylr
subfamily_MTMR9_pd Subfamily MTMR9 112-503 8.4e-110 359.5 In-house 2-392 (393) alignment 
Range on Protein: 112-503
Range on HMM: 2-392/393.0
FSYNPksSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSG
| |..    .. | |..  |.  .|...  .  .| |.. |.|...|..||....|||...  ... |..||.. |.|||||| ||..|.. |.||||.|
ffyrs..vatiledgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcg

FY-TRCVDDELLLEAISQTNpgsQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWL
    || .|| ||... ...   .  ..|||| |  |...|. | | | |..| ...     .|..... .||.||||.|. .. ....||| ||.||||
ssgkrckedekllnlvlkkl...kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwl

RHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDS---KEVSPIFTQFLDCIW
 .......|   ...... |.|.|.|| ..| | | || |.| ..||| .|| .|.. |||.|||  || |..|. ..   .   |. .|.|  ||||..
sqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvy

QLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQ--RKPDFRNPLYKGftMYGVLNPSTVPYNIQFWCGMYNRF
|...|||..|||||..|  .. | .|.|||.||..... |..|.. .||.|.| .. .  . ..| ||||.      |. ||  |  ...| ..| |.
qilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea..naeviwpsvapqslelWselylrw
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 143-503 9.7e-104 339.3 In-house 39-404 (405) alignment 
Range on Protein: 143-503
Range on HMM: 39-404/405.0
NRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGF-YTRCVDDELLLEAISQTNPgSQFMYVVDT
|  | .|. |..|..||.|.  .|| .  .   .     |||| |.| ||.   . ||.| |||||| |   .|| .|||   ... . | |. .|..|.
ncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsap.sktlylida

RPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKT-------PTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVkVEKASV
||||||.|| | | |.||  || | .. || | ||||.| ||.||    .  .        |   |   .| .||. |||.|..|  | .. . .   |.
rpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgnsi

LVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSC
||||||||||| |. |.. |||||.||| .|. .||||||.|.||||| | ||| |. .| |||| ||||| .||..|||  |||  ..|| | | . ||
lvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsc

QFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGvLNPSTVPYNIQFWCGMYNRF
..| || ||.||| . .|  || |.|  .      | || |.   .   ..|      ...|   | |.
kygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqs.ikpklysrclelwkacymrv
subfamily_MTMR3_pd Subfamily MTMR3 234-500 1.5e-92 303.7 In-house 173-439 (442) alignment 
Range on Protein: 234-500
Range on HMM: 173-439/442.0
QFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCElKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKAS
. . .|| |    |.|||| | |.|.|. | |    |.|. ||| .|.|...| .... ..|  |..|| ||.  ||...  .. | . ...||. |. .
kkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrp

VLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDG--DSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHV
||||||||||||.|. ..| .||||.||| .|. .|.|.||...||||. |||| .   |..| .|.| |.||.. || .|||..||||| ||. .  | 
vlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqht

FSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFtMYGVLNPSTVPYNIQFWCGMY
.|| || ||.|..|.||. .|.|.| ||| .|.... ..|| |||    . || |..   ....|  .|
ysclfGtflansekereeekvkertlsvWsllrakekeyrnllykek.teavllpavsvrelklwsevy
subfamily_MTMR5_pd Subfamily MTMR5 243-497 7.6e-58 188.5 In-house 206-476 (483) alignment 
Range on Protein: 243-497
Range on HMM: 206-476/483.0
PKLNAMANRAAGKGYENeDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTP----TMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHC
 .| .. ...  |...  . . .. |  . . .|  ...|..||| .|  .|.    ... ||. .| | ||. |.....    ... . ....||||  
aaLYvlgeksqlknvks.evdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvsl

SDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSK-EVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFG
 |||| |||| |.| .||||.|||..|  .|.||||...||.|..|. .    ..  ..|.| |||||..|...||| |||||. .|  .  |  |..| 
EdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfr

NFLGNCQKDREDLRV----------YEKTHSVWPFLV---QRKPDFRNPLYKGFTMyGVLNPSTVPYNIQFWC
 || .....| .  .           . ..||| ..    .| | | | ||..     || ||.   ... |.
tfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynflyspdes.evlrPssnvsslkvWd
subfamily_MTMR10_pd Subfamily MTMR10 144-477 7.2e-54 175.0 In-house 24-338 (380) alignment 
Range on Protein: 144-477
Range on HMM: 24-338/380.0
RNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAIcRCSQPLSGFYTRCVDDELLLEAISQTNPGSqfmyvvdtrp
...  .  |   . . |.|. .|||.|..   |   |.   . | |.... . . .|.. |.|.      .   . |  || . ...|.           
daivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaall.rlsalqeaesadkekeekmlelvrkchpan..........

klnamanraagkgyenednyaN--IRFRFMGIENIHVMRSSLQKLLEVCELKTPT-----MSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLV
                     .  ..     ...|. . .. .|| |.| . |..       ..|| ||...||  .....   . ..|.|  .| ||..
.....................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvil

HCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQF
  |.| |    |.| |...|||.||| .|.  ||.|||...||.| .|.||.. ..|. ||.|  |||| .||.|||| .|||.| ||. ..|...|. |
qesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgif

GNFLGNCQKDREDL------RVYEKTHSVWPFLVQRKPDFRNPLYKG
..|| |... |.         . .| .    .| . ..|.|..||..
ltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyae
subfamily_pats1_pd Subfamily pats1 394-476 6.3e-26 82.9 In-house 551-633 (691) alignment 
Range on Protein: 394-476
Range on HMM: 551-633/691.0
EVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYK
  |||| |||| .|||  .||  ||||| .|| . ...|| .||||| .  |.. . .|.....|.| |  | |  | | |||
sfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllyk
subfamily_MTMR3_pd Subfamily MTMR3 134-229 7.5e-25 80.6 In-house 31-128 (442) alignment 
Range on Protein: 134-229
Range on HMM: 31-128/442.0
SDFGRMGI-PNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYT-RCVDDELLLEAISQT
... |.|   . .| |.|.| ....||.|| ...||||.|  ..  ...||| .|.|.. . .|.| |.. |||||  |... |. .|| ||.||...
eeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiaka
subfamily_pats1_pd Subfamily pats1 269-391 2.4e-21 67.8 In-house 339-463 (691) alignment 
Range on Protein: 269-391
Range on HMM: 339-463/691.0
RFMGIENIHVMRSSLQKLLE-VCELKTPtMSEFlSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQV---CSVASILLDPFYRTFK
 |. .   . ..    .||. . .|  . ..|. . .| | |.  .| ...| . ... .   .. .|   .|. . . ..    |.| .|.||||||. 
iflslPtrekveerffdllqsilsldgs.ddew.keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtld

GLMILIEKEWISMGHKFSQRCGHLDGD
|...||||||.| |. ||... | . |
GfkvliekewlsyGfPfskinyhkesd
PTPc_DSPc_SM00012 321-429 3.2e-11 38.7 In-house 38-102 (105) alignment 
Range on Protein: 321-429
Range on HMM: 38-102/105.0
IfitkavkveKASVLVHCSDGWDRTAQVCSVASILLDPFYRTfkglmiliekewismghkfsqrcghldgdskevspIFTQFLDCIWQLMEQFPCAFEFN
          ...|.||||.|..||.... .. .| .  ..|                                    . ........|..| | .....
s.........skpvvVhCsaGvgRtgtfvaldillqqleket...................................kevdifqivkelrkqRpgmvqte

ENFLLEIHD
|..|  .. 
eqylflyra
subfamily_MTMR5_pd Subfamily MTMR5 134-208 3.3e-10 31.4 In-house 12-93 (483) alignment 
Range on Protein: 134-208
Range on HMM: 12-93/483.0
SDFGRMGIPN-------RNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQP
 |. |.|. .        .. |. .|..|..| .||  ||||..|   ..   .|   ..|.||  .  . |.| . | ...
qdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_pats1_pd Subfamily pats1 130-210 1.6e-07 22.1 In-house 9-91 (691) alignment 
Range on Protein: 130-210
Range on HMM: 9-91/691.0
IDPISDFGRMGIPNR-NWTITDANrNYEICSTYPPEIVVPKSVTLGTVVGSSkFRSKERVPVLSYLYKENNAA---ICRCSQPLS
  .. .. |...    .| ...   . ...  ||. |.|||.|.   .| .   . . ..||||.  ..| ..   ||   ||. 
yslliegqrlkldldkdwrvvefl.srdlseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslfricvynqpfn
0045098 (Phosphotyrosine protein) phosphatases II 258-356 2.5e-07 25.9 In-house 126-231 (278) alignment 
Range on Protein: 258-356
Range on HMM: 126-231/278.0
ENEDNYANIRFRFMGIENIHVMRSSLQKlLEVCELKTPTMSEFLSGLES--SGWLRHIKAIMDAGIFITKAVKV------EKASVLVHCSDGWDRTAQVC
..|... ..  |.. ..|..|.|..|.. ..|. |. ... .. .  ..  . .|.... | .|  .. . . .      ..  |||||| |..||. ..
lseevlddytlrtllvtnltveredles.rgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlv

SVASILL
 .  .| 
aaylmle
Vps36_ESCRT-II Vacuolar protein sorting protein 36 Vps36 24-59 1.8e-06 16.2 Pfam-A 36-71 (89) alignment 
Range on Protein: 24-59
Range on HMM: 36-71/89.0
ANGILYLTATHLIYVEASGAARKETWIALHHIATVE
 || .|||  .||||. .  ..|.  . |...  ||
qnGrvyLTshrliyvdsadpkkkslsleLklvesve
0044763 (Phosphotyrosine protein) phosphatases II 322-351 4.8e-06 21.8 In-house 101-130 (178) alignment 
Range on Protein: 322-351
Range on HMM: 101-130/178.0
FITKAVKVEKASVLVHCSDGWDRTAQVCSV
|| .|.. ..  |||||| |..|.. ..  
fieealdekggpvlVHCsaGvgRsgtlvaa
0051429 (Phosphotyrosine protein) phosphatases II 316-357 6.4e-06 21.5 In-house 147-176 (272) alignment 
Range on Protein: 316-357
Range on HMM: 147-176/272.0
IMDagifitkavkveKASVLVHCSDGWDRTAQVCSVASILLD
. |            .  |||||| |.|||. |. .  .||.
lld............ggpvlvHCsaGkdRTGtvvallllllg