Gene TNS1 in Homo sapiens

Synonym: MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, TNS1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP066_AA protein Get Run
HsapP066_AA_221-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 130-316 6.5e-96 312.3 In-house 3-189 (189) alignment
Range on Protein: 130-316
Range on HMM: 3-189/189.0
RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNAD
| .|.. .||| |.||||||.|||....||..|.||..||..|||||. .||.|||||.| ||.||. |||.||||||..|.|||.|||||..|.||.||
ryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkad

PHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIM
|.||||.|.||..||||||..|||.||.||||||.||||||||||..||.....||||||||.||||||||.||.|..|||||.||.
pqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil

subfamily_PTEN_pd Subfamily PTEN 129-299 1.8e-47 156.7 In-house 11-180 (184) alignment
Range on Protein: 129-299
Range on HMM: 11-180/184.0
SRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLN
 |. ||  .||| |.||.|||...|..  |...| .|..| ..|..|| ..| ..|| |||. | .|.. .| ...  | ..| || . .|.. ...||.
krfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwle

ADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIgqPSQRRYVHYFSGLLS
.|..||||.| |  .|| ||.|.||. .|..  .|..||. || .|. ..| | |  |||||||.|.. ||.
edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti..PsqrRYveYyeklle

PTB Phosphotyrosine-binding domain 1868-2004 4.3e-47 148.3 Pfam-A 1-131 (131) alignment
Range on Protein: 1868-2004
Range on HMM: 1-131/131.0
ACNVLFVNSVDMESLTGPQAISK--ATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFrRHYPLNTVTFCDLDPQERKWMKteggapakLFGFVAR
...|.....||..||||..|...  |....|.|.....|. |..||||||.|||||.|| .. ..||||.|..|.....||....        |...|||
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes........llalvar

KQGSTTDNAcHLFA--ELDPNQPASAIVNFVSKVMLNAGQK
...|...|. |||.  ||...|.|..|....|||.|.. ..
epesskenv.hlFqcdeleaeqiaediekalskvklgkkkr

subfamily_Auxilin_pd Subfamily Auxilin 137-299 7.7e-42 135.8 In-house 8-165 (166) alignment
Range on Protein: 137-299
Range on HMM: 8-165/166.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVL
.||. |.| ||| .|||.   |  .. |. .|...| |.| ..||..|||.|  . .||...|.| |||  ..| ||.. ..|. ...||..||.||||.
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDkivpiGQPSQRRYVHYFSGLLS
| |  |   .|...|.. . ..  ....|.. |..||  ..      .||..||..|...||.
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla

subfamily_VSP_pd Subfamily VSP 130-297 9.4e-39 127.5 In-house 26-197 (212) alignment
Range on Protein: 130-297
Range on HMM: 26-197/212.0
RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNA
| ..|  .||| ||||||||.||||. ... .|  ..|||..|. ||  .| ..|| |||  | . .. .| .    |   | ||.. ...| .  ||..
rytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlek

DPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFY---EDKIVPIGQPSQRRYVHYFSGL
|..||...| || .|| | .. |.. .|.|  .|...|| |. .|      .|   .  |||.|||.|.  .
dlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqv

PTEN_1 127-300 3.1e-36 120.0 In-house 9-194 (196) alignment
Range on Protein: 127-300
Range on HMM: 9-194/196.0
SVSRTMEDSCELDLVYVTERIIAVS-FPSTA-----NEENFRSNLREVAQMLKSKHGGN-YLLFNLSERRPD---------ITKLHAKVLEFGWPDLHTP
| ..  ...  ||| |.|.||||.. .||.       |  .| .|..||..|..... . .|..||||....           | . ..|.|...| ..|
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

ALEKICSICKAMDTWLNADP-HNVVVLHNKGNRGRIGVVIAAYMHYSNIsASADQALDRFAMKRFYEDKIvpigQPSQRRYVHYFSGLLSG
 |.... ||| .. || .|| .|||. | |. .|| |.|.|||. |..   .||.||.... ||    .     .|||.|...||. ||..
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 304-430 3.7e-34 108.8 Pfam-A 1-133 (134) alignment
Range on Protein: 304-430
Range on HMM: 1-133/134.0
MNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPV-YTSGIYNIPGDSQTSVCITIEP-GLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIH--
.|.|.|.|...|..|||||...|||.|....|. ...| .... |. . . ..  .|  || .|...||.|....||. ..| .. ||||.|.|. |.  
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiekn

DLGVVFGKEDLDDAFKD--DRFPEYGKVEFVFS
.  . . |..||.| ||  ..|..  |||.||.
qnvltlpkneLDkalkdkdkkfsknfkvelvfe

0036282 (Phosphotyrosine protein) phosphatases II 137-302 3.8e-32 106.7 In-house 9-173 (174) alignment
Range on Protein: 137-302
Range on HMM: 9-173/174.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLS-ERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVV
 |||.|.|.|.|| ..| .  |. .. ... | ..|..|. |.|. .|.  |.| | ..|. ..| ..||| ..| |.......|.....|. ||...|.
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

LHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedKIVPIGQPSQRRYVHYFSGLLSGSI
 | .. .|| |...|||... ..  |...||| ....|..  .   .  |||.|...||. |||||.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgsl

0046846 (Phosphotyrosine protein) phosphatases II 131-298 3.2e-25 84.3 In-house 3-172 (176) alignment
Range on Protein: 131-298
Range on HMM: 3-172/176.0
TMEDSCELDLVYVTERIIAVSFPsTANEENFRSNLREVAQMLKSKhgGNYLLFNLSERR-----------PDITKLHAKVLEFGWPDLHTPALEKICSIC
 ...  .|||.|.....|. |.|  |  .. ...| .  .|||.   | ....|| |..           |...||. ..| ..||| ..| || .....
lrllgldldldyinanlilgsrp.iatqgplprtladflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

KAMDTWLNADphNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedkiVPIGQPSQRRYVHYFSGLL
......|...  ..|. | .. .|| |...|||. ...   |...||... ..|..      .  |.|.|....|  ||
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefelll

0037934 (Phosphotyrosine protein) phosphatases II 133-294 1.8e-23 78.8 In-house 32-237 (243) alignment
Range on Protein: 133-294
Range on HMM: 32-237/243.0
EDSCELDLVYVTERIIAVSFPSTANEEN---------FRSNLREVA----------------------------QMLKSKHGGNYLLFNLSERR---PDI
.|   ..|.|||.|.|| ..| . . |.         .. . . .                             ..|...|...| ...|. ..   .| 
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

TKLHAKVLEFGWPDLHTPA--------LEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedkiVPIGQ
|.|. ... ..||| ..|         |.......... ..|..|....|..| .. .|| |..||||....... ....|.... ..|..    . .  
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....kavqt

PSQRRYVHYF
|||.|.....
psqyrflyea

0038934 (Phosphotyrosine protein) phosphatases II 142-292 1.9e-22 75.3 In-house 15-164 (194) alignment
Range on Protein: 142-292
Range on HMM: 15-164/194.0
YVTERIIAVSFPSTA-----NEENFRSNLREVAQMLKSKHGGNYLLFNLS--ERRPDITKLHA---KVLEFGWPDL-HTPALEKICSICKAMDTWLNADP
..|.|.|| ..|..       ||  | ... . ..||... ...|. .|.  ||  | .....   ..|.. .||  ..| || ........|..||.||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

HNVVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRfyedkivpigqPSQRRYVH
..||. | |. .|| |...|||. |..   ||..|...|..||           |.. ....
ggvvaVHCkaGlgRtGtlvaaYLiyrl.gmsaeeAialfrekR...........pgaipnqd

0039614 (Phosphotyrosine protein) phosphatases II 122-294 1.1e-21 73.0 In-house 53-284 (297) alignment
Range on Protein: 122-294
Range on HMM: 53-284/297.0
PIRNMSVSRTM--------------EDSCELDLVYV-----------TERIIAVSFPSTANEENFRSNLREVA---------------------------
 . |..  | .              ||.. ||. |.           | ..|| ..|.. . |.|   ..|                             
lpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggt

------QMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SN
       .|| .| ..| ...|. .. . .. .  .. .|||| ..|  || ...........|... ....|. | ..  || |..||||. .    ..
ygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

ISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
   ....|.... ..|        .  ||| |.....
ggvdvleavkelreqR.....pgavqtpsqyrflyda

0041856 (Phosphotyrosine protein) phosphatases II 137-298 1e-19 66.3 In-house 16-170 (182) alignment
Range on Protein: 137-298
Range on HMM: 16-170/182.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNY-LLFNLSERRPDITKLHA---KVLEFGWPDLHTPALEKICSICKAMDTwlnadPHN
 .|| |....... |.|.|  .   .  |..||..|.  .. .. .. ||.|.. . ..|.    ..| ..||| ..| |..........       ...
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....egg

VVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRFYedkivPIGQPSQRRYVHYFSGLL
.|. | .. .|| |...|||..... . |...|.. . ..|.       . .|.| ......  .|
pvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqlallel

0043336 (Phosphotyrosine protein) phosphatases II 130-294 5.2e-17 57.7 In-house 50-272 (278) alignment
Range on Protein: 130-294
Range on HMM: 50-272/278.0
RT-------------MEDSCELDLVYV----------TERIIAVSFPSTANEENFRSNLRE----------------------------------VAQML
|.               .. .||. |.          ....|| ..|.. ..|.|.  ..|                                  .  .|
rykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtll

KSKHGGNYLLFNLSER--RPDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQA
| .| ..| ...|     . . .. .  .  .|||| ..|  |. .....||....|. |....|. | ..  || |..||.|. .    ..   ....|
keehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleea

LDRFAMKRfyedkIVPIGQPSQRRYVHYF
.... ..|        .  ||| |.....
vkelreqR.....pgavqtpsqyrflyea

0043147 (Phosphotyrosine protein) phosphatases II 138-298 7.2e-17 57.1 In-house 13-160 (172) alignment
Range on Protein: 138-298
Range on HMM: 13-160/172.0
LDLVYVTERIIAVSFPstaneenFRSNLREVAQMLKSKHGGNylLFNLSER---RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVV
|||.|.. |.||  .|       .|..| .. .|||... .   ..|| |.   ... ..|  ..| ..||| ..| || . .... .|..|. .|...|
ldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpv

VLHNKGNRGRIGVVIAAYMHYsnISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYFSGLL
. | ..  || |...|||. .   . |...|.. . .||        .  |||.|...||. ||
lVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrflyyfekll

0048076 (Phosphotyrosine protein) phosphatases II 153-295 3.4e-16 54.7 In-house 4-139 (145) alignment
Range on Protein: 153-295
Range on HMM: 4-139/145.0
PSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPAL-EKICSICKAMDTWLNADphNVVVLHNKGNRGRIGVVIAA
||   .  ....|  . ..   |. | ....||.  ... ..|. ..| ..||| ..| | | ...........|...  ..|. | .  .|| |...||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

YMHYSnISASADQALDRFAMKRFYedkivPIGQPSQRRYVHYFS
|. ..  . |...||... ..|..      .  |.|.|....| 
ylmll.lgvsleealelvrsqrpg.....avpnpgqlrflyefe

0042113 (Phosphotyrosine protein) phosphatases II 139-294 5.7e-16 54.1 In-house 46-238 (245) alignment
Range on Protein: 139-294
Range on HMM: 46-238/245.0
DLVYVTERIIAVSFPSTANEENFRSNLREV-----------------------------------AQMLKSKHGGNYLLFNLSER--RPDITKLHAKVLE
|. ..|...|| ..|.. . |.|   |.|                                     ..|. .| ..| ...|.    . | .. .  .. 
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

FGWPDLHTPA-LEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
..||| ..|  || ...........|..|....|. | .. .|| |..||||. .    ..   |...|.... ..|        .  ||| |.....
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.....pgavqtpsqyrflyea

0048179 (Phosphotyrosine protein) phosphatases II 152-296 6.6e-15 50.6 In-house 3-142 (144) alignment
Range on Protein: 152-296
Range on HMM: 3-142/144.0
FPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHA--KVLEFGWPDLHTPAL-EKICSICKAMDTWLNadPHNVVVLHNKGNRGRIGVV
.||   .  ....|  . ..   |. | ....||.| ..     .   ..| ..||| ..| | | ...........|.  ....|. | .. .|| |..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

IAAYMHYSNiSASADQALDRFAMKRFyedkiVPIGQPSQRRYVHYFSG
.|||. . .   |...||... ..|.       .  |.|.|...... 
vaaylmkkl.glsleealalvrsrrp.....gavpnpgqlrfLleyek

0049260 (Phosphotyrosine protein) phosphatases II 161-298 1.7e-14 49.2 In-house 18-149 (152) alignment
Range on Protein: 161-298
Range on HMM: 18-149/152.0
FRSNLREVAQMLKSKHGGNYLLFNLS-ERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYsnIS
 . .| .. .|||. . . ..  .   |.  . .. . ..| . ||| ..| |. .  ..  .. .|. |....|. | ..  || |...|||. .    
gpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lg

ASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYFSGLL
 |...|.... .||      . .  |.|.|....|..||
vsleeavalvrekR.....pgavpnpgqlrflyefekll

0049772 (Phosphotyrosine protein) phosphatases II 142-294 4.2e-14 48.4 In-house 155-275 (314) alignment
Range on Protein: 142-294
Range on HMM: 155-275/314.0
YvteriiavSFPSTANEENFRsnlrevaqmlkskhggnyllfnlSER--RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWlnaDPHNVVVLHNK
.        ..|. |. |...                       .|   ... ..|. |.| . .|| ..| || . .........   |....|. | |
g........neptaadlellk.......................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCk

GNRGRIGV-VIAAYMHYSNiSASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYF
. .|| |. |.|||. . .   |...||... .||..  . . | |. |  .....
aGkgRtgtfvvaaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefilea

0040439 (Phosphotyrosine protein) phosphatases II 137-294 4.6e-14 48.1 In-house 46-241 (249) alignment
Range on Protein: 137-294
Range on HMM: 46-241/249.0
ELDLVYVTERIIAVSFPSTANEENFRSNLRE-----------------------------------VAQMLKSKHGGNYLLFNLSERR-PDITKLHAKVL
 .|. |.. |.|| ..| .   |.|.  |.|                                   . ..|. .. ..| ...|   .  | .... ...
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

EF-GWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHY
 . .||| ..|  .| ......|....|... ....|. | ..  || |..||||. .     .   ....|.. . ..|        .  |.| |....
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.....pgavqnpeqyrflye

F
.
a

0046845 (Phosphotyrosine protein) phosphatases II 134-294 1.4e-13 46.4 In-house 66-269 (284) alignment
Range on Protein: 134-294
Range on HMM: 66-269/284.0
DSCELDLVYVTERIIAVSFPSTANEENF-----------------------------RSNLREVAQM-------LKSKHGGNYLLFNLSERRPD---ITK
| ..|||.|.. ..|| ..|   . |.|                             ...  || ..       |. .. ..| ...|. .. .    ..
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

LHAKVLEFGWPDLHTPA-LEKICSICKAMDTWLNA-DPHNVVVLHNKGNRGRIGVVIAAYMHYSNI-------SASADQALDRFAMKRFYedkivPIGQP
 .     ..||| ..|. .| . .........|.. ......| | ..  || |..||... .. .         .. .|. |. ..|..      . ..
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg.....mvqtl

SQRRYVHYF
.| |.|...
eqyrfvyea

SH2 SH2 domain 1733-1827 9.5e-12 35.4 Pfam-A 1-77 (77) alignment
Range on Protein: 1733-1827
Range on HMM: 1-77/77.0
WYKPEISREQAIALLKD-QEPGAFIIRDSHSFRGAYGLAMKVSSppptimqqnkkgdmtheLVRHFLIETGPRGvKLKGCpNEPNFGSLSALVYQH
||  .||||.|  ||.. ...|.|..|.|.|. | | |... ..                  |.|. |..  .| |.    .. .| ||. ||. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.................kvkhyriqsleng.kyyit.enekfsslqeLvehY

PTPc_DSPc_SM00012 202-316 1.3e-11 40.0 In-house 8-104 (105) alignment
Range on Protein: 202-316
Range on HMM: 8-104/105.0
FGWPDLHTPA-LEKICSICKAMDTWLNADP-HNVVVLHNKGNRGRIGVVIAAYMHYSNISASAdqaldrfamkrfyedkivpiGQPSQRRYVHYFSGLLS
 |||| ..|   ..|.....|.... |.   .. ||.| .   || |...|...........                     ..... ..|...    .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelrkqRp

GSIKMNNKPLFLHHVIM
|....... |||.....
gmvqteeqylflyrall

0045098 (Phosphotyrosine protein) phosphatases II 136-294 1.9e-11 39.4 In-house 5-267 (278) alignment
Range on Protein: 136-294
Range on HMM: 5-267/278.0
CELDLVYVTERIIAVSFPSTANEENFRSNLR---------------------------------------------------------------------
 .||| . .|.... ..||. .. ....||                                                                      
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------EVAQMlKSKHGGNYLLFNLSERRPDITKLHAKVLEF-GWPDLHTPALE---KICSICKAMDTWLN------------A
                      .. .. .  .   .|. ||. .|.|..... ..| . .||| ..| |.    . .... .. .|.             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

DPHNVVVLHNKGNRGRIGVVIAAYMHYSNI--SASADQALDRFAMKRfyedkIV-PIGQPSQRRYVHYF
|....|. | .   || |...|||. ....    ....|.. . ..|         .  ..| |....|
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR.....pglavqnleqyrflyef

0045450 (Phosphotyrosine protein) phosphatases II 140-294 2.1e-11 39.6 In-house 141-299 (307) alignment
Range on Protein: 140-294
Range on HMM: 141-299/307.0
LVYVTERIIAVSFPSTANEENFRSnlrEVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGW---PDLHTPA-LEKICSICKAMDTWLNAD-PHNVV
||. . ...|  .|..  | ...     .  .|. .| ..| ...|   . | |. . .|  | .   || ..|  .| ...........|... ....|
lvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpv

VLHNKGNRGRIGVVIAAYMHYSNIS-------ASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
. | ..  || |..||||. ....         ....|.... ..|        .  |.| |.....
lVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeqyrflyea

0051082 (Phosphotyrosine protein) phosphatases II 138-294 2.4e-11 39.0 In-house 6-147 (151) alignment
Range on Protein: 138-294
Range on HMM: 6-147/151.0
LDLVYVTERIIAVSFPSTaneenfrsnlrEVAQMLksKHGGNYLLFNLSERR---PDITKLHA---KVLEFGWPDLHTPALEKICSICKAMDTWLNADPH
... |||..... ..|.            .. ..|  |. | .  .|| .      .   |..   .|| . ..| ..| |. .  .....  .|.....
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVVVLHNKGNRGRIGVVIAAYMHYSNisASADQALDRFAMKRFyedkivPIGQPSQRRYVHYF
..|. | .. .|| |...|.|... .   |...||. . .||.       . ||.| .....|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp......gvvqpnqqflfqlf

0044763 (Phosphotyrosine protein) phosphatases II 131-294 8.5e-11 37.3 In-house 14-166 (178) alignment
Range on Protein: 131-294
Range on HMM: 14-166/178.0
TMEDSCELDLVYVTERIIAVSFPStaneenfrsnlREVAQMLKSKhGGNyLLFNLSE---------RRPDITKLHAKVLEFGWPDLHTPA-LEKICSICK
 .| |  ............ |.|.            .  ..||   | . .. ||.|          . . .. . ..| ...|| ..|  || .  ...
glersdyinaseilpglylgslpp...........addlellkel.git.hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefve

AMDTWLNADPHNVVVlHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRfyedkIvPIGQPSQRRYVHYF
.....|. ....|.| | .  .|| |...|||. ... . |...|.... ..|        .  |.|.|....|
fieealdekggpvlV.HCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR.....p.ivpnpgqlrqLyef

0040438 (Phosphotyrosine protein) phosphatases II 138-294 3.4e-10 35.2 In-house 69-271 (317) alignment
Range on Protein: 138-294
Range on HMM: 69-271/317.0
LDLVYV----------TERIIAVSFPSTANEENFRSNLRE-----VAQM------------------------------LKSKHGGNYLLFNLSERR--P
||. |.          . ..|| ..|     |.|   . |     .  .                              |. .. ... |..|       
ldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd

DITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMH-----YSNiSASADQALDRFAMKRfyedkIVPIGQ
. .         |||| ..|  .. . ....|....|. ||...|. | ..  || |..||||.      . .   ....|.... ..|        .  
sesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.....pgavqt

PSQRRYVHYF
|.| |.....
peqyrflyda

0047943 (Phosphotyrosine protein) phosphatases II 170-293 2.8e-09 32.3 In-house 140-266 (273) alignment
Range on Protein: 170-293
Range on HMM: 140-266/273.0
QMLKSKHGGNYLLFNLSERR--PDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SNISAS
 .|. .. ..| ...|  ..   . ..    .. .|||| ..|  || . .........|.|.  ...|| | ..  || |..||... .     .   .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADQALDRFAMKRFYedkivPIGQPSQRRYVHY
...|. .. ..|..      .  |.|.|....
vleavkllrsqRpg.....mvqtpeqyrflye

subfamily_PTPDC1_pd Subfamily PTPDC1 196-273 4e-09 31.2 In-house 82-155 (182) alignment
Range on Protein: 196-273
Range on HMM: 82-155/182.0
HAKVLEFGWPDLHTPALEKICSICKAMDTWLNADphnVVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKR
.  | .|||.|  ...||.|  | | ..  |. .    | .|    .|| ||.||.|. |.. . .|..|..    ||
giyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaiklvrskr

C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 21-67 2.9e-08 23.3 Pfam-A 1-50 (53) alignment
Range on Protein: 21-67
Range on HMM: 1-50/53.0
HRFKVKTFKKVKPCGICRQVI---TQEGCTCKVCSFSCHRKCQAKVAAPC
|... ..||. . |  |.. .      |..|. |....| ||  ||.  |
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkec

0051299 (Phosphotyrosine protein) phosphatases II 170-293 9.6e-08 27.3 In-house 152-280 (288) alignment
Range on Protein: 170-293
Range on HMM: 152-280/288.0
QMLKSKHGGNYLLFNLSER------RPDITKLHAKVLEFGWPDLHTPA-LEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMHY----SNI
 .|. .. ..| ...|  .       .. ..       ..||| ..|  .| . .........|. .....|| | .   || |..||... .     . 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

SASADQALDRFAMKRFYedkivPIGQPSQRRYVHY
  .. .|. |. ..|..      .  |.| |.|..
gvdvleavkrlreqRpg.....mvqtpeqyrfvye

0036941 (Phosphotyrosine protein) phosphatases II 200-294 6.9e-06 21.0 In-house 160-272 (297) alignment
Range on Protein: 200-294
Range on HMM: 160-272/297.0
LE--------------FGWPDLHTPA-LEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHYSNIS-------ASADQALDRFAMKRFYe
.               .|||| ..|   . . .........|..  ....|. | ..  || |..|||.. .. .         .  .|.  . ..|.  
tdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.

dkivPIGQPSQRRYVHYF
     . ...| |.....
....avqtleqyrflyea