Gene TNS1 in Homo sapiens

Synonym: MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, TNS1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP066_AA protein Get Run
HsapP066_AA_221-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 130-316 6.5e-96 312.3 In-house 3-189 (189) alignment 
Range on Protein: 130-316
Range on HMM: 3-189/189.0
RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNAD
| .|.. .||| |.||||||.|||....||..|.||..||..|||||. .||.|||||.| ||.||. |||.||||||..|.|||.|||||..|.||.||
ryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkad

PHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIM
|.||||.|.||..||||||..|||.||.||||||.||||||||||..||.....||||||||.||||||||.||.|..|||||.||.
pqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
subfamily_PTEN_pd Subfamily PTEN 129-299 1.8e-47 156.7 In-house 11-180 (184) alignment 
Range on Protein: 129-299
Range on HMM: 11-180/184.0
SRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLN
 |. ||  .||| |.||.|||...|..  |...| .|..| ..|..|| ..| ..|| |||. | .|.. .| ...  | ..| || . .|.. ...||.
krfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwle

ADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIgqPSQRRYVHYFSGLLS
.|..||||.| |  .|| ||.|.||. .|..  .|..||. || .|. ..| | |  |||||||.|.. ||.
edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvti..PsqrRYveYyeklle
PTB Phosphotyrosine-binding domain 1868-2004 4.3e-47 148.3 Pfam-A 1-131 (131) alignment 
Range on Protein: 1868-2004
Range on HMM: 1-131/131.0
ACNVLFVNSVDMESLTGPQAISK--ATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFrRHYPLNTVTFCDLDPQERKWMKteggapakLFGFVAR
...|.....||..||||..|...  |....|.|.....|. |..||||||.|||||.|| .. ..||||.|..|.....||....        |...|||
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes........llalvar

KQGSTTDNAcHLFA--ELDPNQPASAIVNFVSKVMLNAGQK
...|...|. |||.  ||...|.|..|....|||.|.. ..
epesskenv.hlFqcdeleaeqiaediekalskvklgkkkr
subfamily_Auxilin_pd Subfamily Auxilin 137-299 7.7e-42 135.8 In-house 8-165 (166) alignment 
Range on Protein: 137-299
Range on HMM: 8-165/166.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVL
.||. |.| ||| .|||.   |  .. |. .|...| |.| ..||..|||.|  . .||...|.| |||  ..| ||.. ..|. ...||..||.||||.
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDkivpiGQPSQRRYVHYFSGLLS
| |  |   .|...|.. . ..  ....|.. |..||  ..      .||..||..|...||.
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla
subfamily_VSP_pd Subfamily VSP 130-297 9.4e-39 127.5 In-house 26-197 (212) alignment 
Range on Protein: 130-297
Range on HMM: 26-197/212.0
RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNA
| ..|  .||| ||||||||.||||. ... .|  ..|||..|. ||  .| ..|| |||  | . .. .| .    |   | ||.. ...| .  ||..
rytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlek

DPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFY---EDKIVPIGQPSQRRYVHYFSGL
|..||...| || .|| | .. |.. .|.|  .|...|| |. .|      .|   .  |||.|||.|.  .
dlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqv
PTEN_1 127-300 3.1e-36 120.0 In-house 9-194 (196) alignment 
Range on Protein: 127-300
Range on HMM: 9-194/196.0
SVSRTMEDSCELDLVYVTERIIAVS-FPSTA-----NEENFRSNLREVAQMLKSKHGGN-YLLFNLSERRPD---------ITKLHAKVLEFGWPDLHTP
| ..  ...  ||| |.|.||||.. .||.       |  .| .|..||..|..... . .|..||||....           | . ..|.|...| ..|
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

ALEKICSICKAMDTWLNADP-HNVVVLHNKGNRGRIGVVIAAYMHYSNIsASADQALDRFAMKRFYEDKIvpigQPSQRRYVHYFSGLLSG
 |.... ||| .. || .|| .|||. | |. .|| |.|.|||. |..   .||.||.... ||    .     .|||.|...||. ||..
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 304-430 3.7e-34 108.8 Pfam-A 1-133 (134) alignment 
Range on Protein: 304-430
Range on HMM: 1-133/134.0
MNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPV-YTSGIYNIPGDSQTSVCITIEP-GLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIH--
.|.|.|.|...|..|||||...|||.|....|. ...| .... |. . . ..  .|  || .|...||.|....||. ..| .. ||||.|.|. |.  
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiekn

DLGVVFGKEDLDDAFKD--DRFPEYGKVEFVFS
.  . . |..||.| ||  ..|..  |||.||.
qnvltlpkneLDkalkdkdkkfsknfkvelvfe
0036282 (Phosphotyrosine protein) phosphatases II 137-302 3.8e-32 106.7 In-house 9-173 (174) alignment 
Range on Protein: 137-302
Range on HMM: 9-173/174.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLS-ERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVV
 |||.|.|.|.|| ..| .  |. .. ... | ..|..|. |.|. .|.  |.| | ..|. ..| ..||| ..| |.......|.....|. ||...|.
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

LHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedKIVPIGQPSQRRYVHYFSGLLSGSI
 | .. .|| |...|||... ..  |...||| ....|..  .   .  |||.|...||. |||||.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgsl
0046846 (Phosphotyrosine protein) phosphatases II 131-298 3.2e-25 84.3 In-house 3-172 (176) alignment 
Range on Protein: 131-298
Range on HMM: 3-172/176.0
TMEDSCELDLVYVTERIIAVSFPsTANEENFRSNLREVAQMLKSKhgGNYLLFNLSERR-----------PDITKLHAKVLEFGWPDLHTPALEKICSIC
 ...  .|||.|.....|. |.|  |  .. ...| .  .|||.   | ....|| |..           |...||. ..| ..||| ..| || .....
lrllgldldldyinanlilgsrp.iatqgplprtladflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

KAMDTWLNADphNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedkiVPIGQPSQRRYVHYFSGLL
......|...  ..|. | .. .|| |...|||. ...   |...||... ..|..      .  |.|.|....|  ||
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefelll
0037934 (Phosphotyrosine protein) phosphatases II 133-294 1.8e-23 78.8 In-house 32-237 (243) alignment 
Range on Protein: 133-294
Range on HMM: 32-237/243.0
EDSCELDLVYVTERIIAVSFPSTANEEN---------FRSNLREVA----------------------------QMLKSKHGGNYLLFNLSERR---PDI
.|   ..|.|||.|.|| ..| . . |.         .. . . .                             ..|...|...| ...|. ..   .| 
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

TKLHAKVLEFGWPDLHTPA--------LEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYedkiVPIGQ
|.|. ... ..||| ..|         |.......... ..|..|....|..| .. .|| |..||||....... ....|.... ..|..    . .  
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....kavqt

PSQRRYVHYF
|||.|.....
psqyrflyea
0038934 (Phosphotyrosine protein) phosphatases II 142-292 1.9e-22 75.3 In-house 15-164 (194) alignment 
Range on Protein: 142-292
Range on HMM: 15-164/194.0
YVTERIIAVSFPSTA-----NEENFRSNLREVAQMLKSKHGGNYLLFNLS--ERRPDITKLHA---KVLEFGWPDL-HTPALEKICSICKAMDTWLNADP
..|.|.|| ..|..       ||  | ... . ..||... ...|. .|.  ||  | .....   ..|.. .||  ..| || ........|..||.||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

HNVVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRfyedkivpigqPSQRRYVH
..||. | |. .|| |...|||. |..   ||..|...|..||           |.. ....
ggvvaVHCkaGlgRtGtlvaaYLiyrl.gmsaeeAialfrekR...........pgaipnqd
0039614 (Phosphotyrosine protein) phosphatases II 122-294 1.1e-21 73.0 In-house 53-284 (297) alignment 
Range on Protein: 122-294
Range on HMM: 53-284/297.0
PIRNMSVSRTM--------------EDSCELDLVYV-----------TERIIAVSFPSTANEENFRSNLREVA---------------------------
 . |..  | .              ||.. ||. |.           | ..|| ..|.. . |.|   ..|                             
lpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggt

------QMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SN
       .|| .| ..| ...|. .. . .. .  .. .|||| ..|  || ...........|... ....|. | ..  || |..||||. .    ..
ygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

ISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
   ....|.... ..|        .  ||| |.....
ggvdvleavkelreqR.....pgavqtpsqyrflyda
0041856 (Phosphotyrosine protein) phosphatases II 137-298 1e-19 66.3 In-house 16-170 (182) alignment 
Range on Protein: 137-298
Range on HMM: 16-170/182.0
ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNY-LLFNLSERRPDITKLHA---KVLEFGWPDLHTPALEKICSICKAMDTwlnadPHN
 .|| |....... |.|.|  .   .  |..||..|.  .. .. .. ||.|.. . ..|.    ..| ..||| ..| |..........       ...
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....egg

VVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRFYedkivPIGQPSQRRYVHYFSGLL
.|. | .. .|| |...|||..... . |...|.. . ..|.       . .|.| ......  .|
pvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqlallel
0043336 (Phosphotyrosine protein) phosphatases II 130-294 5.2e-17 57.7 In-house 50-272 (278) alignment 
Range on Protein: 130-294
Range on HMM: 50-272/278.0
RT-------------MEDSCELDLVYV----------TERIIAVSFPSTANEENFRSNLRE----------------------------------VAQML
|.               .. .||. |.          ....|| ..|.. ..|.|.  ..|                                  .  .|
rykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtll

KSKHGGNYLLFNLSER--RPDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQA
| .| ..| ...|     . . .. .  .  .|||| ..|  |. .....||....|. |....|. | ..  || |..||.|. .    ..   ....|
keehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleea

LDRFAMKRfyedkIVPIGQPSQRRYVHYF
.... ..|        .  ||| |.....
vkelreqR.....pgavqtpsqyrflyea
0043147 (Phosphotyrosine protein) phosphatases II 138-298 7.2e-17 57.1 In-house 13-160 (172) alignment 
Range on Protein: 138-298
Range on HMM: 13-160/172.0
LDLVYVTERIIAVSFPstaneenFRSNLREVAQMLKSKHGGNylLFNLSER---RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVV
|||.|.. |.||  .|       .|..| .. .|||... .   ..|| |.   ... ..|  ..| ..||| ..| || . .... .|..|. .|...|
ldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpv

VLHNKGNRGRIGVVIAAYMHYsnISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYFSGLL
. | ..  || |...|||. .   . |...|.. . .||        .  |||.|...||. ||
lVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrflyyfekll
0048076 (Phosphotyrosine protein) phosphatases II 153-295 3.4e-16 54.7 In-house 4-139 (145) alignment 
Range on Protein: 153-295
Range on HMM: 4-139/145.0
PSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPAL-EKICSICKAMDTWLNADphNVVVLHNKGNRGRIGVVIAA
||   .  ....|  . ..   |. | ....||.  ... ..|. ..| ..||| ..| | | ...........|...  ..|. | .  .|| |...||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

YMHYSnISASADQALDRFAMKRFYedkivPIGQPSQRRYVHYFS
|. ..  . |...||... ..|..      .  |.|.|....| 
ylmll.lgvsleealelvrsqrpg.....avpnpgqlrflyefe
0042113 (Phosphotyrosine protein) phosphatases II 139-294 5.7e-16 54.1 In-house 46-238 (245) alignment 
Range on Protein: 139-294
Range on HMM: 46-238/245.0
DLVYVTERIIAVSFPSTANEENFRSNLREV-----------------------------------AQMLKSKHGGNYLLFNLSER--RPDITKLHAKVLE
|. ..|...|| ..|.. . |.|   |.|                                     ..|. .| ..| ...|.    . | .. .  .. 
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

FGWPDLHTPA-LEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
..||| ..|  || ...........|..|....|. | .. .|| |..||||. .    ..   |...|.... ..|        .  ||| |.....
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.....pgavqtpsqyrflyea
0048179 (Phosphotyrosine protein) phosphatases II 152-296 6.6e-15 50.6 In-house 3-142 (144) alignment 
Range on Protein: 152-296
Range on HMM: 3-142/144.0
FPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHA--KVLEFGWPDLHTPAL-EKICSICKAMDTWLNadPHNVVVLHNKGNRGRIGVV
.||   .  ....|  . ..   |. | ....||.| ..     .   ..| ..||| ..| | | ...........|.  ....|. | .. .|| |..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

IAAYMHYSNiSASADQALDRFAMKRFyedkiVPIGQPSQRRYVHYFSG
.|||. . .   |...||... ..|.       .  |.|.|...... 
vaaylmkkl.glsleealalvrsrrp.....gavpnpgqlrfLleyek
0049260 (Phosphotyrosine protein) phosphatases II 161-298 1.7e-14 49.2 In-house 18-149 (152) alignment 
Range on Protein: 161-298
Range on HMM: 18-149/152.0
FRSNLREVAQMLKSKHGGNYLLFNLS-ERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYsnIS
 . .| .. .|||. . . ..  .   |.  . .. . ..| . ||| ..| |. .  ..  .. .|. |....|. | ..  || |...|||. .    
gpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lg

ASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYFSGLL
 |...|.... .||      . .  |.|.|....|..||
vsleeavalvrekR.....pgavpnpgqlrflyefekll
0049772 (Phosphotyrosine protein) phosphatases II 142-294 4.2e-14 48.4 In-house 155-275 (314) alignment 
Range on Protein: 142-294
Range on HMM: 155-275/314.0
YvteriiavSFPSTANEENFRsnlrevaqmlkskhggnyllfnlSER--RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWlnaDPHNVVVLHNK
.        ..|. |. |...                       .|   ... ..|. |.| . .|| ..| || . .........   |....|. | |
g........neptaadlellk.......................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCk

GNRGRIGV-VIAAYMHYSNiSASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYF
. .|| |. |.|||. . .   |...||... .||..  . . | |. |  .....
aGkgRtgtfvvaaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefilea
0040439 (Phosphotyrosine protein) phosphatases II 137-294 4.6e-14 48.1 In-house 46-241 (249) alignment 
Range on Protein: 137-294
Range on HMM: 46-241/249.0
ELDLVYVTERIIAVSFPSTANEENFRSNLRE-----------------------------------VAQMLKSKHGGNYLLFNLSERR-PDITKLHAKVL
 .|. |.. |.|| ..| .   |.|.  |.|                                   . ..|. .. ..| ...|   .  | .... ...
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

EF-GWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SNISASADQALDRFAMKRfyedkIVPIGQPSQRRYVHY
 . .||| ..|  .| ......|....|... ....|. | ..  || |..||||. .     .   ....|.. . ..|        .  |.| |....
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR.....pgavqnpeqyrflye

F
.
a
0046845 (Phosphotyrosine protein) phosphatases II 134-294 1.4e-13 46.4 In-house 66-269 (284) alignment 
Range on Protein: 134-294
Range on HMM: 66-269/284.0
DSCELDLVYVTERIIAVSFPSTANEENF-----------------------------RSNLREVAQM-------LKSKHGGNYLLFNLSERRPD---ITK
| ..|||.|.. ..|| ..|   . |.|                             ...  || ..       |. .. ..| ...|. .. .    ..
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

LHAKVLEFGWPDLHTPA-LEKICSICKAMDTWLNA-DPHNVVVLHNKGNRGRIGVVIAAYMHYSNI-------SASADQALDRFAMKRFYedkivPIGQP
 .     ..||| ..|. .| . .........|.. ......| | ..  || |..||... .. .         .. .|. |. ..|..      . ..
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg.....mvqtl

SQRRYVHYF
.| |.|...
eqyrfvyea
SH2 SH2 domain 1733-1827 9.5e-12 35.4 Pfam-A 1-77 (77) alignment 
Range on Protein: 1733-1827
Range on HMM: 1-77/77.0
WYKPEISREQAIALLKD-QEPGAFIIRDSHSFRGAYGLAMKVSSppptimqqnkkgdmtheLVRHFLIETGPRGvKLKGCpNEPNFGSLSALVYQH
||  .||||.|  ||.. ...|.|..|.|.|. | | |... ..                  |.|. |..  .| |.    .. .| ||. ||. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.................kvkhyriqsleng.kyyit.enekfsslqeLvehY
PTPc_DSPc_SM00012 202-316 1.3e-11 40.0 In-house 8-104 (105) alignment 
Range on Protein: 202-316
Range on HMM: 8-104/105.0
FGWPDLHTPA-LEKICSICKAMDTWLNADP-HNVVVLHNKGNRGRIGVVIAAYMHYSNISASAdqaldrfamkrfyedkivpiGQPSQRRYVHYFSGLLS
 |||| ..|   ..|.....|.... |.   .. ||.| .   || |...|...........                     ..... ..|...    .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelrkqRp

GSIKMNNKPLFLHHVIM
|....... |||.....
gmvqteeqylflyrall
0045098 (Phosphotyrosine protein) phosphatases II 136-294 1.9e-11 39.4 In-house 5-267 (278) alignment 
Range on Protein: 136-294
Range on HMM: 5-267/278.0
CELDLVYVTERIIAVSFPSTANEENFRSNLR---------------------------------------------------------------------
 .||| . .|.... ..||. .. ....||                                                                      
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------EVAQMlKSKHGGNYLLFNLSERRPDITKLHAKVLEF-GWPDLHTPALE---KICSICKAMDTWLN------------A
                      .. .. .  .   .|. ||. .|.|..... ..| . .||| ..| |.    . .... .. .|.             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

DPHNVVVLHNKGNRGRIGVVIAAYMHYSNI--SASADQALDRFAMKRfyedkIV-PIGQPSQRRYVHYF
|....|. | .   || |...|||. ....    ....|.. . ..|         .  ..| |....|
dsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR.....pglavqnleqyrflyef
0045450 (Phosphotyrosine protein) phosphatases II 140-294 2.1e-11 39.6 In-house 141-299 (307) alignment 
Range on Protein: 140-294
Range on HMM: 141-299/307.0
LVYVTERIIAVSFPSTANEENFRSnlrEVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGW---PDLHTPA-LEKICSICKAMDTWLNAD-PHNVV
||. . ...|  .|..  | ...     .  .|. .| ..| ...|   . | |. . .|  | .   || ..|  .| ...........|... ....|
lvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpv

VLHNKGNRGRIGVVIAAYMHYSNIS-------ASADQALDRFAMKRfyedkIVPIGQPSQRRYVHYF
. | ..  || |..||||. ....         ....|.... ..|        .  |.| |.....
lVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeqyrflyea
0051082 (Phosphotyrosine protein) phosphatases II 138-294 2.4e-11 39.0 In-house 6-147 (151) alignment 
Range on Protein: 138-294
Range on HMM: 6-147/151.0
LDLVYVTERIIAVSFPSTaneenfrsnlrEVAQMLksKHGGNYLLFNLSERR---PDITKLHA---KVLEFGWPDLHTPALEKICSICKAMDTWLNADPH
... |||..... ..|.            .. ..|  |. | .  .|| .      .   |..   .|| . ..| ..| |. .  .....  .|.....
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVVVLHNKGNRGRIGVVIAAYMHYSNisASADQALDRFAMKRFyedkivPIGQPSQRRYVHYF
..|. | .. .|| |...|.|... .   |...||. . .||.       . ||.| .....|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp......gvvqpnqqflfqlf
0044763 (Phosphotyrosine protein) phosphatases II 131-294 8.5e-11 37.3 In-house 14-166 (178) alignment 
Range on Protein: 131-294
Range on HMM: 14-166/178.0
TMEDSCELDLVYVTERIIAVSFPStaneenfrsnlREVAQMLKSKhGGNyLLFNLSE---------RRPDITKLHAKVLEFGWPDLHTPA-LEKICSICK
 .| |  ............ |.|.            .  ..||   | . .. ||.|          . . .. . ..| ...|| ..|  || .  ...
glersdyinaseilpglylgslpp...........addlellkel.git.hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefve

AMDTWLNADPHNVVVlHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKRfyedkIvPIGQPSQRRYVHYF
.....|. ....|.| | .  .|| |...|||. ... . |...|.... ..|        .  |.|.|....|
fieealdekggpvlV.HCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR.....p.ivpnpgqlrqLyef
0040438 (Phosphotyrosine protein) phosphatases II 138-294 3.4e-10 35.2 In-house 69-271 (317) alignment 
Range on Protein: 138-294
Range on HMM: 69-271/317.0
LDLVYV----------TERIIAVSFPSTANEENFRSNLRE-----VAQM------------------------------LKSKHGGNYLLFNLSERR--P
||. |.          . ..|| ..|     |.|   . |     .  .                              |. .. ... |..|       
ldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd

DITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMH-----YSNiSASADQALDRFAMKRfyedkIVPIGQ
. .         |||| ..|  .. . ....|....|. ||...|. | ..  || |..||||.      . .   ....|.... ..|        .  
sesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.....pgavqt

PSQRRYVHYF
|.| |.....
peqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 170-293 2.8e-09 32.3 In-house 140-266 (273) alignment 
Range on Protein: 170-293
Range on HMM: 140-266/273.0
QMLKSKHGGNYLLFNLSERR--PDITKLHAKVLEFGWPDLHTP-ALEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHY----SNISAS
 .|. .. ..| ...|  ..   . ..    .. .|||| ..|  || . .........|.|.  ...|| | ..  || |..||... .     .   .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADQALDRFAMKRFYedkivPIGQPSQRRYVHY
...|. .. ..|..      .  |.|.|....
vleavkllrsqRpg.....mvqtpeqyrflye
subfamily_PTPDC1_pd Subfamily PTPDC1 196-273 4e-09 31.2 In-house 82-155 (182) alignment 
Range on Protein: 196-273
Range on HMM: 82-155/182.0
HAKVLEFGWPDLHTPALEKICSICKAMDTWLNADphnVVVLHNKGNRGRIGVVIAAYMHYSNiSASADQALDRFAMKR
.  | .|||.|  ...||.|  | | ..  |. .    | .|    .|| ||.||.|. |.. . .|..|..    ||
giyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaiklvrskr
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 21-67 2.9e-08 23.3 Pfam-A 1-50 (53) alignment 
Range on Protein: 21-67
Range on HMM: 1-50/53.0
HRFKVKTFKKVKPCGICRQVI---TQEGCTCKVCSFSCHRKCQAKVAAPC
|... ..||. . |  |.. .      |..|. |....| ||  ||.  |
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkec
0051299 (Phosphotyrosine protein) phosphatases II 170-293 9.6e-08 27.3 In-house 152-280 (288) alignment 
Range on Protein: 170-293
Range on HMM: 152-280/288.0
QMLKSKHGGNYLLFNLSER------RPDITKLHAKVLEFGWPDLHTPA-LEKICSICKAMDTWLNaDPHNVVVLHNKGNRGRIGVVIAAYMHY----SNI
 .|. .. ..| ...|  .       .. ..       ..||| ..|  .| . .........|. .....|| | .   || |..||... .     . 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

SASADQALDRFAMKRFYedkivPIGQPSQRRYVHY
  .. .|. |. ..|..      .  |.| |.|..
gvdvleavkrlreqRpg.....mvqtpeqyrfvye
0036941 (Phosphotyrosine protein) phosphatases II 200-294 6.9e-06 21.0 In-house 160-272 (297) alignment 
Range on Protein: 200-294
Range on HMM: 160-272/297.0
LE--------------FGWPDLHTPA-LEKICSICKAMDTWLNAD-PHNVVVLHNKGNRGRIGVVIAAYMHYSNIS-------ASADQALDRFAMKRFYe
.               .|||| ..|   . . .........|..  ....|. | ..  || |..|||.. .. .         .  .|.  . ..|.  
tdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.

dkivPIGQPSQRRYVHYF
     . ...| |.....
....avqtleqyrflyea