Gene TNS3 in Homo sapiens

Synonym: TEM6, TENS1, TNS3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP067_AA protein Get Run
HsapP067_AA_174-289 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 103-288 1.7e-98 320.7 In-house 4-189 (189) alignment
Range on Protein: 103-288
Range on HMM: 4-189/189.0
TMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNL
 .|| ..||||||||||||.|||| ..||.| .||..|...|||||.|.|||.||||||||..|||.|..|.|||.|.||.|.|.|.|||...|||....
yveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadp

QHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASPLFLHFVIL
|.|||.||.|||||||||.|.||.....|||||.||||||||.|.|||.|. .||||.|||...||||||..|.|.||||||.|||
qnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil

PTB Phosphotyrosine-binding domain 1413-1547 7.6e-47 147.5 Pfam-A 1-131 (131) alignment
Range on Protein: 1413-1547
Range on HMM: 1-131/131.0
ACNVWYLNSVEMESLTGHQAIQK--ALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFrRHYPVNSVIFCALDPQDRKWIKdgpsskVFGFVARKQ
...|..|..|...||||..|...  | . .| ... .... |..||||||.|||||.|| .. ..||.|||..|......|.. .      ....|||..
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes......llalvarep

GSATDNVcHLFA--EHDPEQPASAIVNFVSKVMIGSPKK
.|...|| |||.  |...||.|..|....|||..|..|.
esskenv.hlFqcdeleaeqiaediekalskvklgkkkr

subfamily_PTEN_pd Subfamily PTEN 104-271 2.7e-45 149.6 In-house 14-180 (184) alignment
Range on Protein: 104-271
Range on HMM: 14-180/184.0
MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNL
 |.|  |||.||||.|||...||   |. |  .|..|...|..|| |.| ..|| ||..|| .|.. ... ..  . ..|||. . .|..  |.||... 
kedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedk

QHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDkvSALMQPSQKRYVQFLSGLLS
..|||.||. |||| ||.|..|.  ..   .|..||. || ... ..  ...  |||.|||.. . ||.
knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk..kgvtiPsqrRYveYyeklle

subfamily_Auxilin_pd Subfamily Auxilin 109-271 2.5e-42 137.4 In-house 8-165 (166) alignment
Range on Protein: 109-271
Range on HMM: 8-165/166.0
GLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVI
 ||..||| ||| .||||   | .|  |...|  .| |.| ..||| |||.. |. .||. .....|||. .||.|... ..|.   |||. . ..|||.
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDkvsalMQPSQKRYVQFLSGLLS
||  |.   .|..|... |...  ....|.. |..|.   .     ..||.|||...|..||.
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla

subfamily_VSP_pd Subfamily VSP 105-268 2.5e-38 126.1 In-house 29-196 (212) alignment
Range on Protein: 105-268
Range on HMM: 29-196/212.0
EEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQ
..|  |||||.||||||.|||.   .. |   ..||.|.|. || |.| |.|| ||. || . .| ... .   .   | |... ...|  . ||. .|.
qdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlk

HVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKF---YDDKVSALMQPSQKRYVQFLSG
.|..|||.||||| | .. ...  ...  .|...|| |. ..      .|   .  |||||||..|  
nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq

PTEN_1 106-272 5.6e-35 115.9 In-house 16-194 (196) alignment
Range on Protein: 106-272
Range on HMM: 16-194/196.0
EGHGLDLTYITERIIAVS-FPAGC-----SEESYLHNLQEVTRMLKSKHGDN-YLVLNLSEKR------YDLTK-LNPKIM--DVGWPELHAPPLDKMCT
... |||||||.||||.. .|.       .|  |. .| .| ..|.....|. .||.||||..      |||..  . ...  .....  .||.|.... 
ptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfd

ICKAQESWLNSNL-QHVVVIHCRGGKGRIGVVISSYMHFTNVsASADQALDRFAMKKFYDDKVsalmQPSQKRYVQFLSGLLSG
|||  ..|| |.  ..||..||..|.|| |.|. .|. ...   .||.||.... |     .     .|||.|.... . ||..
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 277-402 5e-32 101.9 Pfam-A 2-133 (134) alignment
Range on Protein: 277-402
Range on HMM: 2-133/134.0
NASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPV-YTSGIYNVGPENPSRICIVIEPAQLL-KGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQ--G
| ..|.|. .||.| |||.|.| |.|..| |. ...| .... |.   |.  . .|| || .|. .|||.|...||. .. ... |||..|.|  ..   
npkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFieknq

YGLVFGKEDLDNASKD--DRFPDYGKVELVFS
. | . |..||.|.||  ..|..  ||||||.
nvltlpkneLDkalkdkdkkfsknfkvelvfe

0036282 (Phosphotyrosine protein) phosphatases II 109-273 7.7e-30 99.3 In-house 9-172 (174) alignment
Range on Protein: 109-273
Range on HMM: 9-172/174.0
GLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLS-EKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVV
 |||.|||.|.|| ..|.   |. . .... | ..|..|. ..|.. |.  |.|.||..|. ......||  ..|.|.......|. |..|... ...|.
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

IHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddKVSALMQPSQKRYVQFLSGLLSGS
.||..|.|| |...  |.. ..   |...||| .......  .  .   ||| |... .. |||||
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgs

0046846 (Phosphotyrosine protein) phosphatases II 104-266 2.6e-25 84.6 In-house 4-168 (176) alignment
Range on Protein: 104-266
Range on HMM: 4-168/176.0
MEEGHGLDLTYITERIIAVSFPaGCSEESYLHNLQEVTRMLKSKhgDNYLVLNLSEKR-----------YDLTKLNPKIMDVGWPELHAPPLDKMCTICK
.. |..|||.||....|. |.| ..  ... ..|..  .|||.   . ..|.|| | .            .|.||. ... ..||. ..|.|. ......
rllgldldldyinanlilgsrp.iatqgplprtladflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllelle

AQESWLNSNlqHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddkvSALMQPSQKRYVQFL
. ...|...  ..|..||..|.|| |...  |.  ..   |...||... .....     |.  |.| |...  
firealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyef

0038934 (Phosphotyrosine protein) phosphatases II 114-262 3.1e-25 84.4 In-house 15-188 (194) alignment
Range on Protein: 114-262
Range on HMM: 15-188/194.0
YITERIIAVSFPAGC-----SEESYLHNLQEVTRMLKSKHGDNYLVLNLS--EKRYDLTKLNP---KIMDVGWPE-LHAPPLDKMCTICKAQESWLNSNL
.||.|.|| ..|.        || | ...  . |.||... ...||..|.  |. || ...     ....  .|.  ..|.|. ....... . .|| . 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QHVVVIHCRGGKGRIGVVISSYMHFTnVSASADQALDRFAMKK---------------FYDDKVSALMQPSQKRY
..||..|| .|.|| |... .|.  .    ||..|...|..|.               .|..  .| ..|.....
ggvvaVHCkaGlgRtGtlvaaYLiyr.lgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpel

0039614 (Phosphotyrosine protein) phosphatases II 104-263 7.2e-22 73.6 In-house 77-281 (297) alignment
Range on Protein: 104-263
Range on HMM: 77-281/297.0
MEEGHGLDLTYI-----------TERIIAVSFPAGCSEESYLHNLQEVT---------------------------------RMLKSKHGDNYLVLNLSE
.|.|. ||..||           | ..|| ..|   . |.... ..|                                   ..|| .| |.| | .|. 
pedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlev

KRYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVSA
.... ..    .  .|||. ..|| |. .. .... ...|...  ...|..|| .|.|| |..|  |. .    ..   ....|.... ...       |
tnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.....pga

LMQPSQKRYV
 . ||| |..
vqtpsqyrfl

0037934 (Phosphotyrosine protein) phosphatases II 102-264 1.3e-21 72.7 In-house 31-235 (243) alignment
Range on Protein: 102-264
Range on HMM: 31-235/243.0
PtmEEGHGLDLTYITERIIAVSFPAGCSEES---------------YLHNLQEVT----------------------RMLKSKHGDNYLVLNLSEKR---
.  .    ..|.|.|.|.|| ..|   . |.               .. .| | .                      ..|...|.|.| | .|. ..   
g..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldl

YDLTKLNPKIMDVGWPELHAPP--------LDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddkvSA
.|||.|. ... ..||. ..|.        ||........  |.|. . ...|..||..|.|| |..|  |.. .... ....|.... .....     |
ddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....ka

LMQPSQKRYVQ
   ||| |...
vqtpsqyrfly

0041856 (Phosphotyrosine protein) phosphatases II 107-266 2.7e-21 71.4 In-house 14-166 (182) alignment
Range on Protein: 107-266
Range on HMM: 14-166/182.0
GHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNY-LVLNLSEKRYDLTKLNP---KIMDVGWPELHAPPLDKMCTICKAQESwlnsnL
 |..||.||...... |.||   .  . . |..| ..|.  .. .. ...||.| .|. ..|.    ......||  ..|.||... .... ..      
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....e

QHVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDRFAMKKFYddkvsALMQPSQKRYVQFL
...|..||..|.|| |...  |.. .. . |...|.. . ....      .  .|.| ...| .
ggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqla

0042113 (Phosphotyrosine protein) phosphatases II 105-263 1.9e-19 65.5 In-house 30-235 (245) alignment
Range on Protein: 105-263
Range on HMM: 30-235/245.0
EEGHGLDLTYI----------TERIIAVSFPAGCSEE-----------SYLHNLQEVT------------------------RMLKSKHGDNYLVLNLSE
..|. ||..||          |...|| ..|.  . |           ... .| | .                        ..|. .| |.| | .|. 
pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlev

K--RYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVS
.  ..| .. .  .. ..||. ..|. |. .. .... ...|... ...|..||..|.|| |..|  |. .    ..   |...|.... ...       
tnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.....pg

ALMQPSQKRYV
| . ||| |..
avqtpsqyrfl

0043336 (Phosphotyrosine protein) phosphatases II 106-263 1.4e-18 62.8 In-house 67-269 (278) alignment
Range on Protein: 106-263
Range on HMM: 67-269/278.0
EGHGLDLTYI----------TERIIAVSFPAGCSEESYLHNLQE----------------------------------VTRMLKSKHGDNYLVLNLSEK-
.|  ||..||          ....|| ..|   ..| . . ..|                                  . ..|| .| |.| | .|  . 
lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn

-RYDLTKLNPKIMDVGWPELHAP-PLDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVSAL
 ... ..    .  .|||. ..| .|. .. ..||  ..|. . ...|..||..|.|| |..|  |. .    ..   ....|.... ...      .|.
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.....pgav

MQPSQKRYV
. ||| |..
qtpsqyrfl

0043147 (Phosphotyrosine protein) phosphatases II 108-264 5.8e-17 57.4 In-house 11-154 (172) alignment
Range on Protein: 108-264
Range on HMM: 11-154/172.0
HGLDLTYITERIIAVSFPagcseesYLHNLQEVTRMLKSKHGDNylVLNLSEK---RYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQH
  |||.||. |.||  .|       . ..| .. ||||... .   ..|| |    ...|..|. ... ..||  ..|.|. .  ...  ...|. . ..
syldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspgg

VVVIHCRGGKGRIGVVISSYMHFtnVSASADQALDRFAMKKfyddkVSALMQPSQKRYVQ
.|..||..|.|| |...  |.     . |...|.. . .|.       |   ||| |...
pvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrfly

0048076 (Phosphotyrosine protein) phosphatases II 130-263 9e-17 56.6 In-house 9-135 (145) alignment
Range on Protein: 130-263
Range on HMM: 9-135/145.0
EESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPL-DKMCTICKAQESWLNSNlqHVVVIHCRGGKGRIGVVISSYMHFT
.  || .|  . ..   |. . ..||||.  ...|..|. ... ..||  ..|.| . ....... |..|...  ..|..||. |.|| |...  |. ..
pglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll

nVSASADQALDRFAMKKFYddkvsALMQPSQKRYV
  . |...||... .. ..     | . |.| |..
.lgvsleealelvrsqrpg.....avpnpgqlrfl

0048179 (Phosphotyrosine protein) phosphatases II 127-264 1.7e-15 52.5 In-house 6-138 (144) alignment
Range on Protein: 127-264
Range on HMM: 6-138/144.0
GCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNP--KIMDVGWPELHAPPL-DKMCTICKAQESWLNSNlqHVVVIHCRGGKGRIGVVISS
   .  || .|  . ..   |. . ..|.||.|...     ..  ... ..||  ..|.| . ....... |..|...  ..|..||..|.|| |...  
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaa

YMHFTNvSASADQALDRFAMKKFyddkvSALMQPSQKRYVQ
|. ...   |...||... .. .      | . |.| |...
ylmkkl.glsleealalvrsrrp.....gavpnpgqlrfLl

0040439 (Phosphotyrosine protein) phosphatases II 110-245 2e-15 52.6 In-house 47-225 (249) alignment
Range on Protein: 110-245
Range on HMM: 47-225/249.0
LDLTYITERIIAVSFPAGCSEESYLHNLQE-----------------------------------VTRMLKSKHGDNYLVLNLSEKR-YDLTKLNPKIMD
.|..||. |.|| ..|   . |.... |.|                                   . ..|. .. |.| | .|  .. || ...  . . 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

V-GWPELHAP-PLDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKK
. .||. ..|  .. .. ...| ...|...  ...|..|| .|.|| |..|  |. .    ..   ....|.. . ...
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR

0049260 (Phosphotyrosine protein) phosphatases II 135-264 2.1e-14 48.9 In-house 20-143 (152) alignment
Range on Protein: 135-264
Range on HMM: 20-143/152.0
HNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFtnVSAS
..| .. ||||. . . ...|.  .|. .. ..  .... . ||  ..|.|. .  ..     .|. . ...|..||..|.|| |...  |.       |
ntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvs

ADQALDRFAMKKfyddkVSALMQPSQKRYVQ
...|.... .|.       |   |.| |...
leeavalvrekR.....pgavpnpgqlrfly

0044763 (Phosphotyrosine protein) phosphatases II 98-245 5.7e-14 47.6 In-house 9-151 (178) alignment
Range on Protein: 98-245
Range on HMM: 9-151/178.0
VILSPTMEEGHGLDLTYITERIIAVSFPAgcseesylhnlQEVTRMLKSKHGDnyLVLNLSE---------KRYDLTKLNPKIMDVGWPELHAPP-LDKM
..  . .| . ......|...... |.|.           ..  ..||  . .  ...||.|          .|.... . . . ...|  ..|. |. .
lsnleglersdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehf

CTICKAQESWL-NSNlqHVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDRFAMKK
  .... |..| ...  ..|..||. |.|| |...  |.  .. . |...|.... ...
lefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR

0051082 (Phosphotyrosine protein) phosphatases II 110-264 7e-14 47.2 In-house 6-145 (151) alignment
Range on Protein: 110-264
Range on HMM: 6-145/151.0
LDLTYITERIIAVSFPagcSEesylhnlqEVTRMLksKHGDNYLVLNLSEKR---YDLTKLNP---KIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQ
....|.|..... ..|   ..        .. ..|  |. . . ..|| ..    |.   |.    ..... ..  ..|.|. .  ....  ..|... .
infsyvtgglyrsggp...la........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVVVIHCRGGKGRIGVVISSYMHFTNvsASADQALDRFAMKKFyddkvsALMQPSQKRYVQ
..|..||..|||| |...  |..  .   |...||. . .| .       . ||.| ...|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp......gvvqpnqqflfq

0045450 (Phosphotyrosine protein) phosphatases II 106-262 3e-13 45.6 In-house 101-295 (307) alignment
Range on Protein: 106-262
Range on HMM: 101-295/307.0
EGHGLDLTYI----------------------------------TERIIAVSFPAGcSEESYLHNlqEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKI
.|. |....|                                  . ...|  .|   .|| . .|   . ..|. .| |.| |..|  ...| |.   ..
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn..ftvtllseehldgytvrtlevtdldgtgesrtv

MDVGW---PELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHFTNVS-------ASADQALDRFAMKKfyddkVSALMQPSQ
.   .   |. ..|| .. .. .... ...|...  ...|..||..|.|| |..|  |.  ...         ....|.... ...       |   |.|
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeq

KRY
 |.
yrf

0046845 (Phosphotyrosine protein) phosphatases II 98-245 9.5e-13 43.6 In-house 45-253 (284) alignment
Range on Protein: 98-245
Range on HMM: 45-253/284.0
VILSPTME-------------EGHGLDLTYITERIIAVSFPAGCS-----------------------------EESYLHNLQEVTRM-------LKSKH
|.|... .             .|..||||||. ..|| ..|   .                              . |  . .|| ..       |. ..
VklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev

GDNYLVLNLSEKRYD---LTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNS-NLQHVVVIHCRGGKGRIGVVISSYMHFTNV-------SASADQ
 |.| | .|. ....    ..    .   .||. ..|| .. . ..... ...|.. . ....|.||..|.|| |..|  .. .. .         .. .
kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvle

ALDRFAMKK
|. |. ...
avkrlreqR

SH2 SH2 domain 1275-1368 4.5e-12 36.5 Pfam-A 1-75 (77) alignment
Range on Protein: 1275-1368
Range on HMM: 1-75/77.0
WYKADISREQAIAMLKD-KEPGSFIVRDSHSFRGAYGLAMKVATpppsvlqlnkkagdlaneLVRHFLIECTPKGvrLKGCSNEPYFGSLTALVC
||  .||||.|  .|.. |..|.|.||.|.|. | | |...                      |.|. |... .|     .... .| ||. || 
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg..................kvkhyriqsleng..kyyitenekfsslqeLve

0049772 (Phosphotyrosine protein) phosphatases II 127-259 4.8e-12 41.7 In-house 156-268 (314) alignment
Range on Protein: 127-259
Range on HMM: 156-268/314.0
GCSEESYLHNLQevtrmlkskhgdnylvlnlSEK--RYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWlnsNLQHVVVIHCRGGKGRIG--VVIS
.   ...| .|.                   .|   . ....|. | ... .|  .||.|. .  .... |..   . ...|..||..|||| |  ||. 
neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaa

SYMHFTNVsaSADQALDRFAMKKFYDDKVSALMQPSQ
  |.  .|  |...||... .| ..  . ... |. |
ylmkllgv..sleealedvrlkRpinpnpgfieqleq

C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 24-72 4.9e-12 35.4 Pfam-A 1-52 (53) alignment
Range on Protein: 24-72
Range on HMM: 1-52/53.0
HAFKNKAFKKSKVCGVCKQII---DGQGISCRACKYSCHKKCEAKVVIPCGV
| .. . ||... | .|....     ||..|..|....||||  || . || 
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecgc

0045098 (Phosphotyrosine protein) phosphatases II 108-230 5.3e-12 41.2 In-house 5-233 (278) alignment
Range on Protein: 108-230
Range on HMM: 5-233/278.0
HGLDLTYITERIIAVSFPAGCSEESYLHNLQ---------------------------------------------------------------------
  |||....|.... ..|  ...  || ||                                                                      
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------EVTRMlKSKHGDNYLVLNLSEKRYDLTKLNPKIMDV-GWPELHAPPLD---KMCTICKAQESWLN------------S
                      ..... .  .   .|| ||. .|.||.... ....  .||. ..|.|.    .  ...  ...|.             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

NLQHVVVIHCRGGKGRIGVVISSYMHFTNV
. ...|..||. |.|| |...  |.  ...
dsggpvlVHCsaGvgRtGtlvaaylmlell

0040438 (Phosphotyrosine protein) phosphatases II 107-263 3.6e-11 38.4 In-house 66-268 (317) alignment
Range on Protein: 107-263
Range on HMM: 66-268/317.0
GHGLDLTYI----------TERIIAVSFPAGCSEESYLHNLQEV-----T------------------------------RMLKS--KHGDNYLVLNLSE
|  ||..||          . ..|| ..|   . |.... ..|                                     ..|.   ..| ....| .. 
ggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleved

KRYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMH-----FTNvSASADQALDRFAMKKfyddkVSA
.. . .  .  .   |||. ..|| .| .  ...| ...|. . ...|..|| .|.|| |..|  |.       ..   ....|.... ...       |
lgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.....pga

LMQPSQKRYV
   |.| |..
vqtpeqyrfl

0047943 (Phosphotyrosine protein) phosphatases II 142-263 1.2e-10 36.8 In-house 140-264 (273) alignment
Range on Protein: 142-263
Range on HMM: 140-264/273.0
RMLKSKHGDNYLVLNLSEKR--YDLTKLNPKIMDVGWPELHAP-PLDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSAS
..|. .. |.| | .|  ..  .. ..    .   |||. ..|  |. . ..... ...|...  ...||.||..|.|| |..|  .. .    ..   .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADQALDRFAMKKFYddkvsALMQPSQKRYV
...|. .. .....     . . |.| |..
vleavkllrsqRpg.....mvqtpeqyrfl

PTPc_DSPc_SM00012 174-288 1.7e-10 36.4 In-house 8-104 (105) alignment
Range on Protein: 174-288
Range on HMM: 8-104/105.0
VGWPELHAPP-LDKMCTICKAQESWLNSNL-QHVVVIHCRGGKGRIGVVISSYMHFTNVSASAdqaldrfamkkfyddkvsalMQPSQKRYVQFLSGLLS
 |||. ..|   |.......| ... | .  .. ||.||. | || |...  ...  .....                      .......|. |    .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelrkqRp

GSVKMNASPLFLHFVIL
|.|....  |||. ..|
gmvqteeqylflyrall

0051299 (Phosphotyrosine protein) phosphatases II 141-227 2e-09 32.8 In-house 151-243 (288) alignment
Range on Protein: 141-227
Range on HMM: 151-243/288.0
TRMLKSKHGDNYLVLNLSEK------RYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMHF
 ..|. .. |.| | .|  .        . ..    .   .||. ..|. .. . .....  ..|. . ...||.||. |.|| |..|  .. .
vtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdlll

subfamily_PTPDC1_pd Subfamily PTPDC1 163-240 1.7e-08 29.1 In-house 77-150 (182) alignment
Range on Protein: 163-240
Range on HMM: 77-150/182.0
DLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNlqhVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDR
.|.. .  .. .||..  ...|... .| |  .. |. .    | .||  |.|| ||.|..|. ... . .|..|.. 
almeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaikl

0050432 (Phosphotyrosine protein) phosphatases II 150-226 9.3e-07 23.9 In-house 179-255 (308) alignment
Range on Protein: 150-226
Range on HMM: 179-255/308.0
DNYLVLNLSEKR--YDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSnlqHVVVIHCRGGKGRIGVVISSYMH
|.| | .|  .   .. ..    .   .||. ..|| .. . ..... ...|..   ...|.||. | || |..|  .. 
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdll

0036941 (Phosphotyrosine protein) phosphatases II 171-227 2.3e-06 22.6 In-house 173-231 (297) alignment
Range on Protein: 171-227
Range on HMM: 173-231/297.0
IMDVGWPELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF
.   |||. ..|.  . .  .... ...|.    ...|..||..|.|| |..|  .. .
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml

0051429 (Phosphotyrosine protein) phosphatases II 174-240 5.8e-06 21.7 In-house 128-199 (272) alignment
Range on Protein: 174-240
Range on HMM: 128-199/272.0
VGWPELHAPPlDKMCTICKAQESwlnsnlQHVVVIHCRGGKGRIGVVISSYMHFTNVSAS------------ADQALDR
 .||  ..|. . .... ..  .      .. |..||..||.| |.|.  ...  .||..            ...|...
tdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee