Gene TNS3 in Homo sapiens

Synonym: TEM6, TENS1, TNS3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP067_AA protein Get Run
HsapP067_AA_174-289 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 103-288 1.7e-98 320.7 In-house 4-189 (189) alignment 
Range on Protein: 103-288
Range on HMM: 4-189/189.0
TMEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNL
 .|| ..||||||||||||.|||| ..||.| .||..|...|||||.|.|||.||||||||..|||.|..|.|||.|.||.|.|.|.|||...|||....
yveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadp

QHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASPLFLHFVIL
|.|||.||.|||||||||.|.||.....|||||.||||||||.|.|||.|. .||||.|||...||||||..|.|.||||||.|||
qnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
PTB Phosphotyrosine-binding domain 1413-1547 7.6e-47 147.5 Pfam-A 1-131 (131) alignment 
Range on Protein: 1413-1547
Range on HMM: 1-131/131.0
ACNVWYLNSVEMESLTGHQAIQK--ALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFrRHYPVNSVIFCALDPQDRKWIKdgpsskVFGFVARKQ
...|..|..|...||||..|...  | . .| ... .... |..||||||.|||||.|| .. ..||.|||..|......|.. .      ....|||..
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes......llalvarep

GSATDNVcHLFA--EHDPEQPASAIVNFVSKVMIGSPKK
.|...|| |||.  |...||.|..|....|||..|..|.
esskenv.hlFqcdeleaeqiaediekalskvklgkkkr
subfamily_PTEN_pd Subfamily PTEN 104-271 2.7e-45 149.6 In-house 14-180 (184) alignment 
Range on Protein: 104-271
Range on HMM: 14-180/184.0
MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNL
 |.|  |||.||||.|||...||   |. |  .|..|...|..|| |.| ..|| ||..|| .|.. ... ..  . ..|||. . .|..  |.||... 
kedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedk

QHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDkvSALMQPSQKRYVQFLSGLLS
..|||.||. |||| ||.|..|.  ..   .|..||. || ... ..  ...  |||.|||.. . ||.
knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk..kgvtiPsqrRYveYyeklle
subfamily_Auxilin_pd Subfamily Auxilin 109-271 2.5e-42 137.4 In-house 8-165 (166) alignment 
Range on Protein: 109-271
Range on HMM: 8-165/166.0
GLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVI
 ||..||| ||| .||||   | .|  |...|  .| |.| ..||| |||.. |. .||. .....|||. .||.|... ..|.   |||. . ..|||.
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDkvsalMQPSQKRYVQFLSGLLS
||  |.   .|..|... |...  ....|.. |..|.   .     ..||.|||...|..||.
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla
subfamily_VSP_pd Subfamily VSP 105-268 2.5e-38 126.1 In-house 29-196 (212) alignment 
Range on Protein: 105-268
Range on HMM: 29-196/212.0
EEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQ
..|  |||||.||||||.|||.   .. |   ..||.|.|. || |.| |.|| ||. || . .| ... .   .   | |... ...|  . ||. .|.
qdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlk

HVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKF---YDDKVSALMQPSQKRYVQFLSG
.|..|||.||||| | .. ...  ...  .|...|| |. ..      .|   .  |||||||..|  
nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq
PTEN_1 106-272 5.6e-35 115.9 In-house 16-194 (196) alignment 
Range on Protein: 106-272
Range on HMM: 16-194/196.0
EGHGLDLTYITERIIAVS-FPAGC-----SEESYLHNLQEVTRMLKSKHGDN-YLVLNLSEKR------YDLTK-LNPKIM--DVGWPELHAPPLDKMCT
... |||||||.||||.. .|.       .|  |. .| .| ..|.....|. .||.||||..      |||..  . ...  .....  .||.|.... 
ptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfd

ICKAQESWLNSNL-QHVVVIHCRGGKGRIGVVISSYMHFTNVsASADQALDRFAMKKFYDDKVsalmQPSQKRYVQFLSGLLSG
|||  ..|| |.  ..||..||..|.|| |.|. .|. ...   .||.||.... |     .     .|||.|.... . ||..
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 277-402 5e-32 101.9 Pfam-A 2-133 (134) alignment 
Range on Protein: 277-402
Range on HMM: 2-133/134.0
NASPLFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPV-YTSGIYNVGPENPSRICIVIEPAQLL-KGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQ--G
| ..|.|. .||.| |||.|.| |.|..| |. ...| .... |.   |.  . .|| || .|. .|||.|...||. .. ... |||..|.|  ..   
npkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFieknq

YGLVFGKEDLDNASKD--DRFPDYGKVELVFS
. | . |..||.|.||  ..|..  ||||||.
nvltlpkneLDkalkdkdkkfsknfkvelvfe
0036282 (Phosphotyrosine protein) phosphatases II 109-273 7.7e-30 99.3 In-house 9-172 (174) alignment 
Range on Protein: 109-273
Range on HMM: 9-172/174.0
GLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLS-EKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVV
 |||.|||.|.|| ..|.   |. . .... | ..|..|. ..|.. |.  |.|.||..|. ......||  ..|.|.......|. |..|... ...|.
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

IHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddKVSALMQPSQKRYVQFLSGLLSGS
.||..|.|| |...  |.. ..   |...||| .......  .  .   ||| |... .. |||||
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgs
0046846 (Phosphotyrosine protein) phosphatases II 104-266 2.6e-25 84.6 In-house 4-168 (176) alignment 
Range on Protein: 104-266
Range on HMM: 4-168/176.0
MEEGHGLDLTYITERIIAVSFPaGCSEESYLHNLQEVTRMLKSKhgDNYLVLNLSEKR-----------YDLTKLNPKIMDVGWPELHAPPLDKMCTICK
.. |..|||.||....|. |.| ..  ... ..|..  .|||.   . ..|.|| | .            .|.||. ... ..||. ..|.|. ......
rllgldldldyinanlilgsrp.iatqgplprtladflemlkel..gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllelle

AQESWLNSNlqHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddkvSALMQPSQKRYVQFL
. ...|...  ..|..||..|.|| |...  |.  ..   |...||... .....     |.  |.| |...  
firealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyef
0038934 (Phosphotyrosine protein) phosphatases II 114-262 3.1e-25 84.4 In-house 15-188 (194) alignment 
Range on Protein: 114-262
Range on HMM: 15-188/194.0
YITERIIAVSFPAGC-----SEESYLHNLQEVTRMLKSKHGDNYLVLNLS--EKRYDLTKLNP---KIMDVGWPE-LHAPPLDKMCTICKAQESWLNSNL
.||.|.|| ..|.        || | ...  . |.||... ...||..|.  |. || ...     ....  .|.  ..|.|. ....... . .|| . 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QHVVVIHCRGGKGRIGVVISSYMHFTnVSASADQALDRFAMKK---------------FYDDKVSALMQPSQKRY
..||..|| .|.|| |... .|.  .    ||..|...|..|.               .|..  .| ..|.....
ggvvaVHCkaGlgRtGtlvaaYLiyr.lgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpel
0039614 (Phosphotyrosine protein) phosphatases II 104-263 7.2e-22 73.6 In-house 77-281 (297) alignment 
Range on Protein: 104-263
Range on HMM: 77-281/297.0
MEEGHGLDLTYI-----------TERIIAVSFPAGCSEESYLHNLQEVT---------------------------------RMLKSKHGDNYLVLNLSE
.|.|. ||..||           | ..|| ..|   . |.... ..|                                   ..|| .| |.| | .|. 
pedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlev

KRYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVSA
.... ..    .  .|||. ..|| |. .. .... ...|...  ...|..|| .|.|| |..|  |. .    ..   ....|.... ...       |
tnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.....pga

LMQPSQKRYV
 . ||| |..
vqtpsqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 102-264 1.3e-21 72.7 In-house 31-235 (243) alignment 
Range on Protein: 102-264
Range on HMM: 31-235/243.0
PtmEEGHGLDLTYITERIIAVSFPAGCSEES---------------YLHNLQEVT----------------------RMLKSKHGDNYLVLNLSEKR---
.  .    ..|.|.|.|.|| ..|   . |.               .. .| | .                      ..|...|.|.| | .|. ..   
g..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldl

YDLTKLNPKIMDVGWPELHAPP--------LDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYddkvSA
.|||.|. ... ..||. ..|.        ||........  |.|. . ...|..||..|.|| |..|  |.. .... ....|.... .....     |
ddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....ka

LMQPSQKRYVQ
   ||| |...
vqtpsqyrfly
0041856 (Phosphotyrosine protein) phosphatases II 107-266 2.7e-21 71.4 In-house 14-166 (182) alignment 
Range on Protein: 107-266
Range on HMM: 14-166/182.0
GHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNY-LVLNLSEKRYDLTKLNP---KIMDVGWPELHAPPLDKMCTICKAQESwlnsnL
 |..||.||...... |.||   .  . . |..| ..|.  .. .. ...||.| .|. ..|.    ......||  ..|.||... .... ..      
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....e

QHVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDRFAMKKFYddkvsALMQPSQKRYVQFL
...|..||..|.|| |...  |.. .. . |...|.. . ....      .  .|.| ...| .
ggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqla
0042113 (Phosphotyrosine protein) phosphatases II 105-263 1.9e-19 65.5 In-house 30-235 (245) alignment 
Range on Protein: 105-263
Range on HMM: 30-235/245.0
EEGHGLDLTYI----------TERIIAVSFPAGCSEE-----------SYLHNLQEVT------------------------RMLKSKHGDNYLVLNLSE
..|. ||..||          |...|| ..|.  . |           ... .| | .                        ..|. .| |.| | .|. 
pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlev

K--RYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVS
.  ..| .. .  .. ..||. ..|. |. .. .... ...|... ...|..||..|.|| |..|  |. .    ..   |...|.... ...       
tnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR.....pg

ALMQPSQKRYV
| . ||| |..
avqtpsqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 106-263 1.4e-18 62.8 In-house 67-269 (278) alignment 
Range on Protein: 106-263
Range on HMM: 67-269/278.0
EGHGLDLTYI----------TERIIAVSFPAGCSEESYLHNLQE----------------------------------VTRMLKSKHGDNYLVLNLSEK-
.|  ||..||          ....|| ..|   ..| . . ..|                                  . ..|| .| |.| | .|  . 
lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn

-RYDLTKLNPKIMDVGWPELHAP-PLDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKKfyddkVSAL
 ... ..    .  .|||. ..| .|. .. ..||  ..|. . ...|..||..|.|| |..|  |. .    ..   ....|.... ...      .|.
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.....pgav

MQPSQKRYV
. ||| |..
qtpsqyrfl
0043147 (Phosphotyrosine protein) phosphatases II 108-264 5.8e-17 57.4 In-house 11-154 (172) alignment 
Range on Protein: 108-264
Range on HMM: 11-154/172.0
HGLDLTYITERIIAVSFPagcseesYLHNLQEVTRMLKSKHGDNylVLNLSEK---RYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQH
  |||.||. |.||  .|       . ..| .. ||||... .   ..|| |    ...|..|. ... ..||  ..|.|. .  ...  ...|. . ..
syldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspgg

VVVIHCRGGKGRIGVVISSYMHFtnVSASADQALDRFAMKKfyddkVSALMQPSQKRYVQ
.|..||..|.|| |...  |.     . |...|.. . .|.       |   ||| |...
pvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrfly
0048076 (Phosphotyrosine protein) phosphatases II 130-263 9e-17 56.6 In-house 9-135 (145) alignment 
Range on Protein: 130-263
Range on HMM: 9-135/145.0
EESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPL-DKMCTICKAQESWLNSNlqHVVVIHCRGGKGRIGVVISSYMHFT
.  || .|  . ..   |. . ..||||.  ...|..|. ... ..||  ..|.| . ....... |..|...  ..|..||. |.|| |...  |. ..
pglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll

nVSASADQALDRFAMKKFYddkvsALMQPSQKRYV
  . |...||... .. ..     | . |.| |..
.lgvsleealelvrsqrpg.....avpnpgqlrfl
0048179 (Phosphotyrosine protein) phosphatases II 127-264 1.7e-15 52.5 In-house 6-138 (144) alignment 
Range on Protein: 127-264
Range on HMM: 6-138/144.0
GCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNP--KIMDVGWPELHAPPL-DKMCTICKAQESWLNSNlqHVVVIHCRGGKGRIGVVISS
   .  || .|  . ..   |. . ..|.||.|...     ..  ... ..||  ..|.| . ....... |..|...  ..|..||..|.|| |...  
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaa

YMHFTNvSASADQALDRFAMKKFyddkvSALMQPSQKRYVQ
|. ...   |...||... .. .      | . |.| |...
ylmkkl.glsleealalvrsrrp.....gavpnpgqlrfLl
0040439 (Phosphotyrosine protein) phosphatases II 110-245 2e-15 52.6 In-house 47-225 (249) alignment 
Range on Protein: 110-245
Range on HMM: 47-225/249.0
LDLTYITERIIAVSFPAGCSEESYLHNLQE-----------------------------------VTRMLKSKHGDNYLVLNLSEKR-YDLTKLNPKIMD
.|..||. |.|| ..|   . |.... |.|                                   . ..|. .. |.| | .|  .. || ...  . . 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

V-GWPELHAP-PLDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSASADQALDRFAMKK
. .||. ..|  .. .. ...| ...|...  ...|..|| .|.|| |..|  |. .    ..   ....|.. . ...
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR
0049260 (Phosphotyrosine protein) phosphatases II 135-264 2.1e-14 48.9 In-house 20-143 (152) alignment 
Range on Protein: 135-264
Range on HMM: 20-143/152.0
HNLQEVTRMLKSKHGDNYLVLNL-SEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFtnVSAS
..| .. ||||. . . ...|.  .|. .. ..  .... . ||  ..|.|. .  ..     .|. . ...|..||..|.|| |...  |.       |
ntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvs

ADQALDRFAMKKfyddkVSALMQPSQKRYVQ
...|.... .|.       |   |.| |...
leeavalvrekR.....pgavpnpgqlrfly
0044763 (Phosphotyrosine protein) phosphatases II 98-245 5.7e-14 47.6 In-house 9-151 (178) alignment 
Range on Protein: 98-245
Range on HMM: 9-151/178.0
VILSPTMEEGHGLDLTYITERIIAVSFPAgcseesylhnlQEVTRMLKSKHGDnyLVLNLSE---------KRYDLTKLNPKIMDVGWPELHAPP-LDKM
..  . .| . ......|...... |.|.           ..  ..||  . .  ...||.|          .|.... . . . ...|  ..|. |. .
lsnleglersdyinaseilpglylgslpp...........addlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehf

CTICKAQESWL-NSNlqHVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDRFAMKK
  .... |..| ...  ..|..||. |.|| |...  |.  .. . |...|.... ...
lefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR
0051082 (Phosphotyrosine protein) phosphatases II 110-264 7e-14 47.2 In-house 6-145 (151) alignment 
Range on Protein: 110-264
Range on HMM: 6-145/151.0
LDLTYITERIIAVSFPagcSEesylhnlqEVTRMLksKHGDNYLVLNLSEKR---YDLTKLNP---KIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQ
....|.|..... ..|   ..        .. ..|  |. . . ..|| ..    |.   |.    ..... ..  ..|.|. .  ....  ..|... .
infsyvtgglyrsggp...la........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVVVIHCRGGKGRIGVVISSYMHFTNvsASADQALDRFAMKKFyddkvsALMQPSQKRYVQ
..|..||..|||| |...  |..  .   |...||. . .| .       . ||.| ...|
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp......gvvqpnqqflfq
0045450 (Phosphotyrosine protein) phosphatases II 106-262 3e-13 45.6 In-house 101-295 (307) alignment 
Range on Protein: 106-262
Range on HMM: 101-295/307.0
EGHGLDLTYI----------------------------------TERIIAVSFPAGcSEESYLHNlqEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNPKI
.|. |....|                                  . ...|  .|   .|| . .|   . ..|. .| |.| |..|  ...| |.   ..
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn..ftvtllseehldgytvrtlevtdldgtgesrtv

MDVGW---PELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHFTNVS-------ASADQALDRFAMKKfyddkVSALMQPSQ
.   .   |. ..|| .. .. .... ...|...  ...|..||..|.|| |..|  |.  ...         ....|.... ...       |   |.|
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.....pgavqnpeq

KRY
 |.
yrf
0046845 (Phosphotyrosine protein) phosphatases II 98-245 9.5e-13 43.6 In-house 45-253 (284) alignment 
Range on Protein: 98-245
Range on HMM: 45-253/284.0
VILSPTME-------------EGHGLDLTYITERIIAVSFPAGCS-----------------------------EESYLHNLQEVTRM-------LKSKH
|.|... .             .|..||||||. ..|| ..|   .                              . |  . .|| ..       |. ..
VklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev

GDNYLVLNLSEKRYD---LTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNS-NLQHVVVIHCRGGKGRIGVVISSYMHFTNV-------SASADQ
 |.| | .|. ....    ..    .   .||. ..|| .. . ..... ...|.. . ....|.||..|.|| |..|  .. .. .         .. .
kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvle

ALDRFAMKK
|. |. ...
avkrlreqR
SH2 SH2 domain 1275-1368 4.5e-12 36.5 Pfam-A 1-75 (77) alignment 
Range on Protein: 1275-1368
Range on HMM: 1-75/77.0
WYKADISREQAIAMLKD-KEPGSFIVRDSHSFRGAYGLAMKVATpppsvlqlnkkagdlaneLVRHFLIECTPKGvrLKGCSNEPYFGSLTALVC
||  .||||.|  .|.. |..|.|.||.|.|. | | |...                      |.|. |... .|     .... .| ||. || 
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg..................kvkhyriqsleng..kyyitenekfsslqeLve
0049772 (Phosphotyrosine protein) phosphatases II 127-259 4.8e-12 41.7 In-house 156-268 (314) alignment 
Range on Protein: 127-259
Range on HMM: 156-268/314.0
GCSEESYLHNLQevtrmlkskhgdnylvlnlSEK--RYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWlnsNLQHVVVIHCRGGKGRIG--VVIS
.   ...| .|.                   .|   . ....|. | ... .|  .||.|. .  .... |..   . ...|..||..|||| |  ||. 
neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaa

SYMHFTNVsaSADQALDRFAMKKFYDDKVSALMQPSQ
  |.  .|  |...||... .| ..  . ... |. |
ylmkllgv..sleealedvrlkRpinpnpgfieqleq
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 24-72 4.9e-12 35.4 Pfam-A 1-52 (53) alignment 
Range on Protein: 24-72
Range on HMM: 1-52/53.0
HAFKNKAFKKSKVCGVCKQII---DGQGISCRACKYSCHKKCEAKVVIPCGV
| .. . ||... | .|....     ||..|..|....||||  || . || 
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecgc
0045098 (Phosphotyrosine protein) phosphatases II 108-230 5.3e-12 41.2 In-house 5-233 (278) alignment 
Range on Protein: 108-230
Range on HMM: 5-233/278.0
HGLDLTYITERIIAVSFPAGCSEESYLHNLQ---------------------------------------------------------------------
  |||....|.... ..|  ...  || ||                                                                      
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------EVTRMlKSKHGDNYLVLNLSEKRYDLTKLNPKIMDV-GWPELHAPPLD---KMCTICKAQESWLN------------S
                      ..... .  .   .|| ||. .|.||.... ....  .||. ..|.|.    .  ...  ...|.             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

NLQHVVVIHCRGGKGRIGVVISSYMHFTNV
. ...|..||. |.|| |...  |.  ...
dsggpvlVHCsaGvgRtGtlvaaylmlell
0040438 (Phosphotyrosine protein) phosphatases II 107-263 3.6e-11 38.4 In-house 66-268 (317) alignment 
Range on Protein: 107-263
Range on HMM: 66-268/317.0
GHGLDLTYI----------TERIIAVSFPAGCSEESYLHNLQEV-----T------------------------------RMLKS--KHGDNYLVLNLSE
|  ||..||          . ..|| ..|   . |.... ..|                                     ..|.   ..| ....| .. 
ggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleved

KRYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMH-----FTNvSASADQALDRFAMKKfyddkVSA
.. . .  .  .   |||. ..|| .| .  ...| ...|. . ...|..|| .|.|| |..|  |.       ..   ....|.... ...       |
lgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqR.....pga

LMQPSQKRYV
   |.| |..
vqtpeqyrfl
0047943 (Phosphotyrosine protein) phosphatases II 142-263 1.2e-10 36.8 In-house 140-264 (273) alignment 
Range on Protein: 142-263
Range on HMM: 140-264/273.0
RMLKSKHGDNYLVLNLSEKR--YDLTKLNPKIMDVGWPELHAP-PLDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF----TNVSAS
..|. .. |.| | .|  ..  .. ..    .   |||. ..|  |. . ..... ...|...  ...||.||..|.|| |..|  .. .    ..   .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADQALDRFAMKKFYddkvsALMQPSQKRYV
...|. .. .....     . . |.| |..
vleavkllrsqRpg.....mvqtpeqyrfl
PTPc_DSPc_SM00012 174-288 1.7e-10 36.4 In-house 8-104 (105) alignment 
Range on Protein: 174-288
Range on HMM: 8-104/105.0
VGWPELHAPP-LDKMCTICKAQESWLNSNL-QHVVVIHCRGGKGRIGVVISSYMHFTNVSASAdqaldrfamkkfyddkvsalMQPSQKRYVQFLSGLLS
 |||. ..|   |.......| ... | .  .. ||.||. | || |...  ...  .....                      .......|. |    .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelrkqRp

GSVKMNASPLFLHFVIL
|.|....  |||. ..|
gmvqteeqylflyrall
0051299 (Phosphotyrosine protein) phosphatases II 141-227 2e-09 32.8 In-house 151-243 (288) alignment 
Range on Protein: 141-227
Range on HMM: 151-243/288.0
TRMLKSKHGDNYLVLNLSEK------RYDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNsNLQHVVVIHCRGGKGRIGVVISSYMHF
 ..|. .. |.| | .|  .        . ..    .   .||. ..|. .. . .....  ..|. . ...||.||. |.|| |..|  .. .
vtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdlll
subfamily_PTPDC1_pd Subfamily PTPDC1 163-240 1.7e-08 29.1 In-house 77-150 (182) alignment 
Range on Protein: 163-240
Range on HMM: 77-150/182.0
DLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNlqhVVVIHCRGGKGRIGVVISSYMHFTNvSASADQALDR
.|.. .  .. .||..  ...|... .| |  .. |. .    | .||  |.|| ||.|..|. ... . .|..|.. 
almeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaikl
0050432 (Phosphotyrosine protein) phosphatases II 150-226 9.3e-07 23.9 In-house 179-255 (308) alignment 
Range on Protein: 150-226
Range on HMM: 179-255/308.0
DNYLVLNLSEKR--YDLTKLNPKIMDVGWPELHAPP-LDKMCTICKAQESWLNSnlqHVVVIHCRGGKGRIGVVISSYMH
|.| | .|  .   .. ..    .   .||. ..|| .. . ..... ...|..   ...|.||. | || |..|  .. 
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdll
0036941 (Phosphotyrosine protein) phosphatases II 171-227 2.3e-06 22.6 In-house 173-231 (297) alignment 
Range on Protein: 171-227
Range on HMM: 173-231/297.0
IMDVGWPELHAPP-LDKMCTICKAQESWLNSN-LQHVVVIHCRGGKGRIGVVISSYMHF
.   |||. ..|.  . .  .... ...|.    ...|..||..|.|| |..|  .. .
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml
0051429 (Phosphotyrosine protein) phosphatases II 174-240 5.8e-06 21.7 In-house 128-199 (272) alignment 
Range on Protein: 174-240
Range on HMM: 128-199/272.0
VGWPELHAPPlDKMCTICKAQESwlnsnlQHVVVIHCRGGKGRIGVVISSYMHFTNVSAS------------ADQALDR
 .||  ..|. . .... ..  .      .. |..||..||.| |.|.  ...  .||..            ...|...
tdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee