Gene PTPN1 in Homo sapiens

Synonym: PTP1B, PTPN1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP070_AA protein Get Run
HsapP070_AA_1-279 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN1_pd Subfamily PTPN1 9-297 9.7e-167 547.9 In-house 1-290 (290) alignment 
Range on Protein: 9-297
Range on HMM: 1-290/290.0
QIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVV
..||. ....||.|||.||||||.|.||||.|.|.||||||||.|||||||...|||||||||...|||.|||||||||||||..|||.|||||||..||
eldkkrlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MLNRVMEKGSLKCAQYWPQKEE-KEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPE
|||.|.||...||||||||.|| ||...|||.||..||||..|||||||.||||||.|||||||||||||||||||||||||.||.||||||||||||..
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd

HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE
.||.|.||||||||||||||.||||.|..|..| |||||||||||.||.|.|||||||||||||||..||||.|.||||||..|||||.|
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwkelske
0036941 (Phosphotyrosine protein) phosphatases II 3-294 1.6e-102 338.0 In-house 2-293 (297) alignment 
Range on Protein: 3-294
Range on HMM: 2-293/297.0
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQ
..| .|... .  .   .... .   .....||.||.|...|||.|. |.||.|.||..|..||||||.... . .| .|.||||||||...|| |||||
llkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
... .|||....|.|  ||||||| .|.... ..|  ..|. ........||.|.||.... ..|.|.. |||||.|||.||||||||.|.|. .||.  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKEL
.|.|..|||.||||||.||||||..||..| ......    |||.......|. |.| .|| .|.|| | |..|  |... . ........|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll
0050432 (Phosphotyrosine protein) phosphatases II 2-282 8.8e-99 326.0 In-house 30-303 (308) alignment 
Range on Protein: 2-282
Range on HMM: 30-303/308.0
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLhQEDNDYINASLIKME--EAQRSYILTQGPLPNTCGHFWEMV
.. | .|. . .| . . ......   .....||.||.||..|||.|. |.||||.|| .|..||||||....     .| .|.||||||||...|| ||
dllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

WEQKSRGVVMLNRVMEKGSLKCAQYWPQKEE-KEMIFEdtNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKV
|||..| .|||.. .|.|  ||||||| ... . ....  ....||.||.....||||.|||.|| ..|.|.. |||||.|||.|||.||...|.|| .|
weqnvrvIvmLtklvengrekcaqYwplelgggsleyg..kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RESGslspEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRkdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIM
|.|     ..||.|||||||.||.|||...|..| ...|      ||. ...  .|. |.| .|| .|..| | |..| .|...
rksl....pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0047943 (Phosphotyrosine protein) phosphatases II 5-276 1.4e-95 315.2 In-house 3-270 (273) alignment 
Range on Protein: 5-276
Range on HMM: 3-270/273.0
KEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKS
. .|. . .. ... .....    .....||.||.||..|||.|. |.||||.||.....||||||.... . .| .|.||||||||...|| |||||..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

RGVVMLNRVMEKGSLKCAQYWPQKEEK-EMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGS
| .|||....|.|  |||||||..... ......  .. ||.||..|..||||.|||.|| |.|.|.. |||||.|||.|||.|..|.|.|. .||.  .
rviVmLtelvelgrekcaqYwpleggelsltygk..ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

LSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
 .|..||||||||||.||.|||...|..| .. |..    ||.....  .|. |.| .|| .|.|| | |..|
alpsngpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 17-316 8.8e-95 312.9 In-house 21-314 (317) alignment 
Range on Protein: 17-316
Range on HMM: 21-314/317.0
AAIYQDIRHEASDfPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR
   ..|...   | ...||.||.||..|||.|. |.||||.||. ..    .||||||.... . .| .|.||||||||...||.|||||... .|||..
leefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLte

VMEKGSLKCAQYWPQkeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsPEHGPVV
 .|.|  |||||||.  .... ..|  .. ||.||. ....|.|.||.|.| ..|.|.. |||||.|||.|||.|| ..|.|| .|||. .  ...|||.
leelgrekcaqYwpl..getltygd..ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRP
||||||.||.|||..|...| ...|..    ||..... |.|..|.| .|| .|.|| | |..|  |. . . ........| ..  .....  ... ..
VHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkeke

PKRI
.|..
lkll
0046845 (Phosphotyrosine protein) phosphatases II 25-282 2.8e-94 310.9 In-house 11-278 (284) alignment 
Range on Protein: 25-282
Range on HMM: 11-278/284.0
HEAS--DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ-----EDNDYINASLIKME-----EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR
.      ....||.||.|...|||.|. |.||||.||.      ||.||||||....        .. .|.||||||||...|| |||||..| .|||..
sltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlte

VMEKGSLKCAQYWPQKeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLT-TQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPV
 .|.|  |||||||.. .. ....|  .. ||.||..|..|||| |||.||  |.|.|.. |||||.|||.|||.||...|.|| .|||. . .| .||.
lvengrekcaqYwple.gevltygd..ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpi

VVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIM
|||||||.||.|||...|..| ...|..... ||. ...  .|. |.| .|| .|.|| | |..| .|...
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 15-276 5.3e-93 306.9 In-house 24-284 (288) alignment 
Range on Protein: 15-276
Range on HMM: 24-284/288.0
SWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML
 ... ......   |.....|.||.|...|||.|. |.||||.||.     |..||||||.|.. . .| .|.||||||||...|| |||||..| .|||
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvml

NRVMEKGSLKCAQYWPQkeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENL----TTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsP
....|.|  |||||||.  .. ....|  .. ||.||.....||||.||..||     ..|.|.. |||||.|||.|||.|| ..|.|| .||.. .  .
tklvelgrekcaqYwpl..ggsltygd..itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..s

EHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRkdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
 .||||||||||.||.|||...|..| ...|.     ||. ...  .|. |.|..|| .|.|| | |..|
gggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0045450 (Phosphotyrosine protein) phosphatases II 10-275 6.7e-90 297.2 In-house 23-301 (307) alignment 
Range on Protein: 10-275
Range on HMM: 23-301/307.0
IDKSGSWAAIYQDIRHEAS--DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ-----EDNDYINASLI--------KMEEAQRSYILTQGPLPNTCGH
.|    ... .......     .....|.||.||..|||.|. |.||.|.||.      ||.|||||| .        ..   .| .|.||||||.|. .
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENL-TTQETREILHFHYTTWPDFGVPESPASFLN
||.|.|||... .|||.. .|.|. |||||||.. . |. ...  .. ||.||.....||||.||...|  |.|.|.. |||||.|||.|||.|....|.
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn..ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|. .||.  . .|..|||.||||||.||.|||..|...| ...|..  . ||. ... ..|. |.| .|. .|.|| | |..
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 9-280 1.9e-87 288.8 In-house 27-291 (297) alignment 
Range on Protein: 9-280
Range on HMM: 27-291/297.0
QIDKSGSWAAIYQDIRHEASDfpCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ-----EDNDYINASLIKMEEA-QRSYILTQGPLPNTCGHFWEMVWEQ
. .... . . ....     |  ...|.||.||..|||.|. |.||||.||.      .|.||||||.... .  .| .|.||||||.|...||.|||||
kansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

KSRGVVMLNRVMEKGSlKCAQYWPQKEEkemifEDTNLKLTLISEDIKSYYTVRQLELENltTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
... .|||.. .|.|  |||||||....     .  ... ||.... ...||||.||..|  ..|.|.. ||.|| |||.|||.|....|.|| .|||  
gvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRkdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
. .|..|||.||||||.||.|||..|...| ...|.     ||..... |.|. |.| .|| .|.|| | |..|  |.
aelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_PTPRD_pd Subfamily PTPRD 19-288 2.1e-86 285.8 In-house 28-291 (564) alignment 
Range on Protein: 19-288
Range on HMM: 28-291/564.0
IYQDIRHEaSDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM
 |..|... . |....|. | ||..||| .. ..||||..|.    .|. |||||| |.  .....|| |||||..|.  || |||||.|. .|||... 
eykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

EKGSLKCAQYWPQKEeKEMIfedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGslSPEHGPVVVH
|||  ||..|||.|. .| .    .|. || .|  ...|..|...|.. ...|.||. .||.| ||| |||||..|.|... |||..   .|..||.|||
EkgkvkchkYWPekg.tety...geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVh

CSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQ
||||.||.|||.  | .|   .. |.   ||| ... ..|| |  ..|| .|  | . |. |  ..   . ...
CSaGVGRTGtfividaml...erikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevese
DSPc_SM00195 19-276 6.2e-86 283.3 In-house 5-260 (263) alignment 
Range on Protein: 19-276
Range on HMM: 5-260/263.0
IYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM
 ..... ..|. ... |. .|||..|||... |.||.|.||..|.    .|||||. ||... ...||.||||||.|. .||.||||.|.. .|||.. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGSLKCAQYWPQKEEKEMIFEdtNLKLTLISEDIKS-YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpeHGPVVV
|.|. ||..|||....... |.  .....|.....|.  ...|.|||.. ...|||.. ...|..||| |||.|. |.|..| .|..| | |  .||.||
engkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLADTCLLLMDKRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|||||.||.|||...|..|  ... |.   |||.... |.|| |.|..|| .|..| | |..|
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 19-276 6.2e-86 283.3 In-house 5-260 (263) alignment 
Range on Protein: 19-276
Range on HMM: 5-260/263.0
IYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVM
 ..... ..|. ... |. .|||..|||... |.||.|.||..|.    .|||||. ||... ...||.||||||.|. .||.||||.|.. .|||.. .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGSLKCAQYWPQKEEKEMIFEdtNLKLTLISEDIKS-YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpeHGPVVV
|.|. ||..|||....... |.  .....|.....|.  ...|.|||.. ...|||.. ...|..||| |||.|. |.|..| .|..| | |  .||.||
engkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLADTCLLLMDKRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|||||.||.|||...|..|  ... |.   |||.... |.|| |.|..|| .|..| | |..|
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
0043336 (Phosphotyrosine protein) phosphatases II 18-275 1.6e-85 282.2 In-house 24-274 (278) alignment 
Range on Protein: 18-275
Range on HMM: 24-274/278.0
AIYQDIRHEASdFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
. ......    .....|.||.||..|||.|. |.||||.||. ..    .||||||.... . .| .|.||||||.|...||.||||.... .|||.. 
lefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

MEKGSLKCAQYWPqkeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsPEHGPVVV
.|.|. |||||||   .. . ..|  .. ||..|. ...||||.||..|| . |.|...|.||. |||.|||||....|.|| .|||  .  ...|||.|
velgrvkcaqYwp...ggsltygd..ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlV

HCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|||||.||.|||......| ...|..    ||. ... |.|..|.| .|| .|.|| | |..
HCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 13-278 7e-82 270.2 In-house 6-272 (278) alignment 
Range on Protein: 13-278
Range on HMM: 6-272/278.0
SGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKlhqednDYINASLIKMEeaQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR
|...  ... ...  .   . .| ...|...|||.|. |.||||.|      ||||||.|..   .. .|.||||||.|. .||.|.||.... .|||..
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

VMEKGSLKCAQYWPQkeEKEMIFedTNLKLTLISEDIKSYYTVRQLELENL----TTQETREILHFHYTTWPDFGVPESP--ASFLNFLFKVRESGS---
..|.|  |||||||   .. ...   ....||.||.. ..||.| |...||    .. |.|.. |.||..|||.|||..|  .|||..|  .||  .   
lvelgrekcaqywpe..ggslty..gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

--------LSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMdkrkDpSSVDIKKVLLEMRKFRMG-LIQTADQLRFSYLAVIEGA
        | ...|||.||||||.||.||...|...| |.    . . ||. ... |.|. |.|  .|. .|.|| | ...|  
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell....e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
Y_phosphatase Protein-tyrosine phosphatase 40-276 1e-81 269.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 40-276
Range on HMM: 1-235/235.0
NKNRNRYRDVSPFDHSRIKL-HQED-NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFED
||..|||.|. |.|..|.|| ..|. .|||||. .|. . ....|.|||||..|...||.|||..|.. .|||....|||. |||||||..||... ..|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

TNLKLTLISEDIKSYYTVRQLELENLTTQ-ETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGslSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD
 ...|.  ...... ||.|.|||.. ... |.||. ..|||.||| |||||| |.|... ||..|   ....||||||||||.||.|||...|..|  ..
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqle

KRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
....   ||..... |.|| |.|..|...|. | | |..|
aeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 40-276 1e-81 269.2 In-house 1-235 (235) alignment 
Range on Protein: 40-276
Range on HMM: 1-235/235.0
NKNRNRYRDVSPFDHSRIKL-HQED-NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFED
||..|||.|. |.|..|.|| ..|. .|||||. .|. . ....|.|||||..|...||.|||..|.. .|||....|||. |||||||..||... ..|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

TNLKLTLISEDIKSYYTVRQLELENLTTQ-ETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGslSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMD
 ...|.  ...... ||.|.|||.. ... |.||. ..|||.||| |||||| |.|... ||..|   ....||||||||||.||.|||...|..|  ..
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqle

KRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
....   ||..... |.|| |.|..|...|. | | |..|
aeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 31-276 2.4e-81 268.3 In-house 2-244 (249) alignment 
Range on Protein: 31-276
Range on HMM: 2-244/249.0
PCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWP
...||.||.||..|||.|. |.||||.||.     ...||||||.|..   .| .|.||||||.|...||.|.||.... .|||.. .|.|  |||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

QkeEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFC
.  .... ..|  .. ||.|...|..||||.|||.|| ..|.|..||..|| |||.|||.|....|.|. .||.  .  |..|||.||||||.||.|||.
l..ggsleygd..ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

LADTCLLLMDKRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
.|...| ...|...   ||.. .. ..|. |.| .|. .|.|| | |..|
aaylmleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 14-271 2.5e-79 261.4 In-house 25-278 (293) alignment 
Range on Protein: 14-271
Range on HMM: 25-278/293.0
GSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVM
  ..  |.....  .|  . .|.|..|...|||... |.||||.||    .....|||||. |.  ...| .| ||||||.|  .||.||||.||. .||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LNRVMEKGSLKCAQYWPQKEEKEmIFedTNLKLTLISEDIKSYYTVRQLELENltTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHG
| ...|||  || .|||..||   ..   ..|.||..|. .. ...|.|..|.  ..|.|.. ..|.|.|||.||||.....|.|. .|||. . . ...
ltqlvekgkvkCeeYWPadeepv.ly..Gdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PVVVHCSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
|.|||||||.||.|||   |.   |... ..   |||  .. |.|. |. |.|| .|  | .
PivvhCsaGvGRtGtfialdr...llqaieeedyvdifgivaelReeRnllvqtekqYifih
0042113 (Phosphotyrosine protein) phosphatases II 32-275 1.4e-78 259.0 In-house 1-240 (245) alignment 
Range on Protein: 32-275
Range on HMM: 1-240/245.0
CRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ
..||.||.||..|||.|. |.||.|.||  ..    .||||||.... .  . .|.||||||.|...||.|.||.... .|||.. .|.|  |||||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

keEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLsPEHGPVVVHCSAGIGRSGTFCL
  . .. ..|  .. ||.||.....||||.||..|| . |.||..|.||. |||.|||......|.||  ||.  .  ...|||.||||||.||.|||..
..gesltygd..ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

ADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|...| ...|..    |.. ... |.|..|.| .|| .|.|| | |..
aylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_PTPN3_pd Subfamily PTPN3 12-275 7.5e-78 256.3 In-house 13-272 (280) alignment 
Range on Protein: 12-275
Range on HMM: 13-272/280.0
KSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQ----RSYILTQGPLPNTCGHFWEMVWEQKSRGV
.||.  | .. .     .  . .|..|.| ..|||||..|.|. |.||.....|||||. ..||         || |||||..|. .||.|||||||. .
esGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMLNRVMEKGSLKCAQYWPQKEEKeMIFEdtNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGslSPE
|||  ..|.|  || ||||..|.. . .   ...... .|| .. | .|.| |.. .|.| |.||.. |. ||| |||...|.||.|. .||.    | .
vmlttlverGrvkChqyWPetede.leyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgk

HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDpssVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
. ||||||||||||.| . | .|.| |......   | . ... .||  |. |.|||.| .|   |..
eePvvvhCsaGigrtGvlilletalalieaaep...vypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN6_pd Subfamily PTPN6 2-275 5.5e-77 253.8 In-house 15-294 (306) alignment 
Range on Protein: 2-275
Range on HMM: 15-294/306.0
EMEKEFEQIDKSGSWAAiYQDIRHE--ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH---QEDNDYINASLIK--MEEAQRSYILTQGPLPNTCGH
|.||| |...|.| .   ......|   . .  . .. |.||..|||. . ||||.|..|.     ..|||||. ||  ... ..||| ||| |..|   
elekeeeslekagfeee.feelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMiFedTNLKLTLISEDIKSYYTVRQLELEN-LTTQETREILHFHYTTWPDFGVPESPASFLN
||.|||...|| .||. . .|.|  |||.|||..||||. .   ....| .||. ...|..|.| ...  . .|.||. ..|...||| |||..|  .|.
FWrmvwqensrvivmttkevErgkekCarYWPdeeekee.y..GkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLd

FLFKVRESGSLSP--EHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|| .|..  . .   |.||.|||||||||| ||| . |. | |. |..    .||.|.   .|..| ||.||..| .| | |. 
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0037934 (Phosphotyrosine protein) phosphatases II 31-275 4.2e-76 251.0 In-house 1-239 (243) alignment 
Range on Protein: 31-275
Range on HMM: 1-239/243.0
PCRVAKLPKNKNRNRYRDVSPFDHSRIKLhqEDNDYINASLIKMEEaqrSYILTQGPLPNTCGH----FWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWP
....|.|| |...|||.|. |.||||.||  |..|||||.||.. .    .|.||||||.|. .    ||.|.||.... .|||.. .|.| .|||||||
sfsiallpenlsknrysdilpydhsrvkl..egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

qkeeKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLT-TQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL------SPEHGPVVVHCSAGI
     |. ..|  .. ||.||  ...|||| |.||||  ...||.. |.||. |||.|||.||...|.|| .|||  .        ...|||.||||||.
....gevtygd..ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTFCLADTCLLLMdkrkdpsSVDIKKVLLEMRKFRMG-LIQTADQLRFSYLAVI
||.||...|...|||.       .||. ... ..|. |.|  .|| .|.|| | |..
gRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN9_pd Subfamily PTPN9 9-278 3.2e-75 247.9 In-house 12-290 (297) alignment 
Range on Protein: 9-278
Range on HMM: 12-290/297.0
QIDKSGSwAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKS
. .|.|     |..||.|.      ..||. | ..||| ||  .|..|..| ..|     |||||. .   . ....| |||||..|.  || |||||. 
ekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

RGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL
. .||  ||.|.| |||.||||..||. . | |  |... .. . .. |.||.||..| .|.|.|.. || ...|||.|||.| ||.|..| ||||  .|
lvivmttrvvergrlkcgqyWpleeessaefgd..lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

S-----------PEHGPVVVHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGA
.           |.  |.||||||||||.|||.  | ||   .. .. . ||. ...  .|. |   ||| .|  | ||||.| |
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldicl...srleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN13_pd Subfamily PTPN13 16-276 6.9e-75 246.8 In-house 13-267 (273) alignment 
Range on Protein: 16-276
Range on HMM: 13-267/273.0
WAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNdYINASLIKM--EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
 |  ....|.  .   |.|.|  .||..||||.| |.|..|.|| .| . ||||||||.  .. . .||..|||||.|.  || ||||||.. ..|.   
PaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

MEKGSLKCAQYWPQKEEKEMIFEDtNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgsLSPEHGPVVV
 ||| .|| .|||....|..  ..  |...|.    .. ..||.|..... ..|.||. |.....||| ||| |.|..|.|. .||.   |  ..||.||
kekgkvkchrywPesknkklkvsn.rlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr...lqtdagPivv

HCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|||||||||||.   |. | |... |   ..|.|... ..|. | |..|| ||  | | |..|
hcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPN12_pd Subfamily PTPN12 26-277 2.2e-73 241.7 In-house 26-276 (290) alignment 
Range on Protein: 26-277
Range on HMM: 26-276/290.0
EASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKC
. . ..  ... ..|...|||.|. |.|.||..|..    |..|||||..||  | . .|| .|||||.|   || |.||.. . |||. |..| |  ||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

AQYWPQKEEKEMIFEDtnLKLTLISEDIKS-YYTVRQLELENLttQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsPEHGPVVVHCSAGIG
..|||.. |.|. |..  ...||..|.  .  ...|.|..|.   .|.|..  |||| ||| |||.|. | |... .|||  .   |. |.|||||||.|
erYWpeegeeelefge..fevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvG

RSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
| || .  |    |. ..| |...|. ...||.|| |  |.|| .| .. | ||.| 
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 12-276 8.2e-73 240.2 In-house 25-288 (298) alignment 
Range on Protein: 12-276
Range on HMM: 25-288/298.0
KSGSWAAIYQDIRHEAS---DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKS
|   .|. .| ...  |   ..  .||. |.||..||| |. ..|.||. |..    |. |||||| ..  . . ..|.||.||..|   || ||.|...
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi

RGVVMLNRVMEKGSLKCAQYWPQKEEKEmiFedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSl
  .|||. . |.. .|. .|||......  .   .....| |.. .. ..||.|.... .....||. ..|.|.||| ||||   | |..| ||| | . 
gtiVmltnleeldktkyhkywPdegket..y..geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq.

SPEHGPVVVHCSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
   . ||.|.||||.||||||.  |.   .... |  ..||. .|.  .|| |.|..|| .|  | | ||.|
qagnkpvivqCsaGvgRsGtfiaids...vlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN23_pd Subfamily PTPN23 15-279 6.6e-72 236.7 In-house 20-281 (288) alignment 
Range on Protein: 15-279
Range on HMM: 20-281/288.0
SWAAIYQDIRHEASDFPCRVAKLpkNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKME-EAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
 .. . |.  .|| .. . .|||  . ..||.||. |.||.|.||... .|||||| .|       ..| ||.||..| . || ||.||||. .|||   
kfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllsk

MEKGSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRE--SGSLSPEHGPV
 |.|  |...|||..... . |.|  |..|| |.   ...  |.|.|| | ....... | ..|.||..|||.|| ..|.|| .|..  .    . . |.
eelgkpkvdrYwPedkgetvkfgd..lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPl

VVHCSAGIGRSGTFCLADTCLLLMdkRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAK
|||||||.||.|.|.|  . .  .  .|..  .|| .|.  .|. |   .|. .||.||| ||.| |.
vvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 8-276 1.2e-71 236.1 In-house 7-274 (281) alignment 
Range on Protein: 8-276
Range on HMM: 7-274/281.0
EQIDKSG--SWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWE
.| ...    ..  |.....   | . . .| ..|...|||.... .|..|.|.    .....|||||. ..  . .. || ||||.|... .||.||||
kqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

QKSRGVVMLNRVMEKGSLKCAQYWPqKEEKEMIFedTNLKLTLISEDIKSYYTVRQLELeNLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRES
|| . .||. | .|.| ||| .|||  ...|...  ...... ..|  |. |  |...| . .. ||||. ...||.||| |||.... .|.|  .|.. 
qkvsaivmvtreieagklkChrYWP.ddnselky..gdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

GSLSPEhGPVVVHCSAGIGRSGTFCLADTCLLLMDkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
 . . .  |.|.|||||.||.||.   |. .  ..  .. ...|.| |. |.|| |. ..||  | .| |.||..
tekktk.aplvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 18-280 9.2e-71 233.5 In-house 24-282 (318) alignment 
Range on Protein: 18-280
Range on HMM: 24-282/318.0
AIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
. |. . .. . .    .  | ||..||| .. ..||.|.||..    |. |||||. |   .....|| .|.|||.|.  || |||||.|. .||| ..
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

MEKGSLKCAQYWPQKEEKEMifedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgSLSPEHGPVVV
.|.|  |...|||.|. ...     .|. .| .|   |.|..|......  ..|.|..  .|||.||| |||||.||.|... .|..   .....||.||
eergkakvhryWPskgsrsy....gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.qqksgagpivv

HCSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
|||||.|| |.|.  |.   |... |. . ||. ..  ..|. |  ..|| ||  | | ...|  . 
hCsaGvGrtGvfiavdi...llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 33-275 4.9e-70 230.9 In-house 40-276 (288) alignment 
Range on Protein: 33-275
Range on HMM: 40-276/288.0
RVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQK
 ...|..|...||||.. |.|. |.||..    ...|||||| |. |. .. || |||||..| ..|||.|.|.|.  .|||. ..|.|  || .|||..
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

EEKEMiFedTNLKLTLISEDIKSYYTVRQLELEnlTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpeHGPVVVHCSAGIGRSGTFCLA
....  .   ....||...  .  ...|.|.||   ... .|| ...|..||| ||||| | .|..| .|  . .     ||..||||||.||.|||  .
dkpkn.y..Gsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFial

DTCLLLMDKrkdPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|. .  ...      .|.  .. ..|| |. |.||  |  | | ...
dalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRG_pd Subfamily PTPRG 20-276 1.3e-67 223.4 In-house 25-285 (563) alignment 
Range on Protein: 20-276
Range on HMM: 25-285/563.0
YQD--IRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDN-DYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR
...   .. ..|...  .. |.||..||| .. ..|.||.||..    ... |||||. |.  . .. .| |||||..|.  || |.|||..  .||.  
fealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitn

VMEKGSLKCAQYWPQkEEKEMIfedTNLKLTLISEDIKSYYTVRQLELENLTTQ------ETREILHFHYTTWPDFGVPESPASFLNFLFKvrESGSLSP
. |.|  || .|||. .| | .    .|..|||.|.....||||.| ..||  .      . ... ..|||.||| ||||...  |.|  |  .| .   
lvergrrkcdvYWPk.desety...galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk..ssaanka

EHGPVVVHCSAGIGRSGTFCLADTCLLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
| ||.|||||||.||.||..  || |  .   .. ..|.. ..|  .|  |  |.|| .|  | . |..|
eaGPivvHcsaGvgrtGtyivldtllkqi...qqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 18-291 4.1e-67 221.5 In-house 27-296 (319) alignment 
Range on Protein: 18-291
Range on HMM: 27-296/319.0
AIYQDIRHEASDfPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
  ......  .|   . |. ..||..|||... ..|..|..| .    |. |||||| |   . .. .| ||.|| ||   || ||||..|  ||||...
kefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

MEKGSLKCAQYWPQKEekemIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQ-ETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlSPEHGPVV
 ||. .|. .|||...    . |  .| .|| .|. .. | .|.|.|...... ||||. ||.|| ||| .|||.  | |..| ..|.| .  ...||.|
veklkvklkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre.ktqsgPiv

VHCSAGIGRSGTFCLADTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQW
||||||.|| |||.  |     ... |  . .|. ..  ..|  |  ..|. .| .| | |..| ...   .  |||  
vhCsaGvGRtGtfivlda...mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlr
subfamily_PTPN14_pd Subfamily PTPN14 5-276 6.3e-66 217.4 In-house 14-294 (300) alignment 
Range on Protein: 5-276
Range on HMM: 14-294/300.0
KEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH---QEDNDYINASLIKME--EAQRSYILTQGPLPNTCGHFWEMV
| .|.. ..|   . |. | ..  |  . .||||.|...||..|| |....|..|    .....||||| ||.    ..|||| .||||..|.  ||.||
kilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTL-ISEDIKSyYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKV
|||. . .||| .  |.|  |. .|.|..|.|.   |  . |.|   ||| .| .. ..|.|. | ..| |...|. || ||| |||| . .||..| .|
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

R---ES-GSLS---PEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
.   .   | .    .. ||.||||||.||.|   |.|  .  ... .   ..||||||  .|. || |.||  | .| | ..|.
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne...eidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 15-276 8.2e-65 213.9 In-house 23-281 (305) alignment 
Range on Protein: 15-276
Range on HMM: 23-281/305.0
SWAAIYQDIRHEasDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML
.. | |. . .|  . .. | |  .||..||.... ..|..||.| ..    |.|||||| ..  . . .||..||||.||   ||....| | . .|||
gleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml

NRVMEKGSLKCAQYWPQKEEKEMIFEDTnlKLTLISEDIKSYYTVRQLELEN-LTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpEHG
 ...| |  || ||||... ... |...  ...| ||   | |. |.|.. .  . .|.| .|... |.||| |||....|.|... .|... . . .  
tklveggkdkCrqYWpesktekkefgef..svelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd.kgv

PVVVHCSAGIGRSGTFCLADtclLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|..||||||.||.|.|.  |   . ... |   .||. .|| ..|. ||...|| ||  | . |. |
pllVhCsagvgRtGvfiavd...ialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 34-276 1.7e-63 209.2 In-house 3-240 (250) alignment 
Range on Protein: 34-276
Range on HMM: 3-240/250.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQED----NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLkCAQYWPQKE
||| |.||..||| |. ..|.||. |..|.     |||||| ..  . ....| |||||..|  .|| ||.|.||  .|||. . |..   . |||| ..
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

EKEmiFedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpEHGPVVVHCSAGIGRSGTFCLAD
 ..  .   .....| |..... ||.|.| | . . .. | . ..|...||| ||||   . |..| ||. |   . . .||.|.||||.||||.|.  |
aek..y..GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaid

TcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
.   .... |    ||. ||.  .|| |.. ... .|  | | ....
a...vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Ptp69D_pd Subfamily Ptp69D 17-289 4e-63 208.4 In-house 25-297 (307) alignment 
Range on Protein: 17-289
Range on HMM: 25-297/307.0
AAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNR
|  |. . .. .|  ..|..   |. .||| |. .||. |.||.    .|| |||||| ||  . ....|  |.|. .| | || |..||..  .|||  
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn

VMEKGSLKCAQYWPQKeeKEMIFEDTNlkLTLISEDIKSYYTVRQLELENLT-----TQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpe
. ||   |||.|||.   .|. ..| .   .|.||. .|.|. |.|.. .        ...|... .|||.|.|. |||.. . |... .|||  .|.  
lteknrkkcakYWpie..devqygdil..vklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

HGPVVVHCSAGIGRSGTFCLADtclLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQD
..|.||||||| ||||.|   |   .|... |   .||| ..  ..|. |  |.|  .|  | | |...  ..   | .|.|
rsPivvhCsaGvgrsgifvald...sllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvdd
subfamily_PTPRK_pd Subfamily PTPRK 34-286 1.8e-62 206.0 In-house 37-283 (314) alignment 
Range on Protein: 34-286
Range on HMM: 37-283/314.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQEDN----DYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE
.||  .|...||. |. ..|.||..|.. |.    |||||.||   .  . .| |||||..|   || .|.....  .|||. ..|.| .|| .|||.. 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

EKemiFEDtnLKLTLISEDIKSYYTVRQLELEN--LTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLspEHGPVVVHCSAGIGRSGTFCL
|.   ..|  .|..|.. .... . || . .|.   . .|.||. .|....|||..|| |  ..|... .| .|     |.|..||||||| ||.|||. 
ev...ygd..ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfia

ADTCLLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAkfIMGDSS
 |. | ..   .  . ||. ..  ..|. .. ...| .| .| | ...| .  . |...
idivldmi...eregvvdvfnavktlrsrkvnmveteeqykfiydvileac..lcgeta
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 33-280 3.9e-62 204.7 In-house 13-266 (270) alignment 
Range on Protein: 33-280
Range on HMM: 13-266/270.0
RVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDND----YINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ
 . .  ..|. |||.|. |  ..|..|.....|    ||||  .. .......|| ..||||.|  .|| |.||.|.. .||.  ..|||  ||..|||.
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

KEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELEnlTTQETREILHFHYTTWPDFGVPESPA------SFLNFLFKVRESGSLSPEHGPVVVHCSAGIGR
. .... .|| ..| . .||  .. | ...|.||  .. |.|...||.|.|||| |||...       . |. | .||.| .   . .|..||||||.||
epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

SGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
.||. . |... |....|   .||. ... |.|| || |.|. .| .| | ||.| |..
tGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 30-290 8.6e-62 203.9 In-house 39-289 (315) alignment 
Range on Protein: 30-290
Range on HMM: 39-289/315.0
FPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYW
.| .|||  .||..||| .. ..|.||..|     ... ||.||..|.  . .| || .|||.... . || .|.|..   .|||. ..|.   |. .||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PQKeekEMIFEdtNLKLTLISEDIKSYYTVRQLelENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPehGPVVVHCSAGIGRSGTF
| |   ..|.   .. .|..||.... |||| |       .. ||.. .|||.||| |||..  ...|.  .|.     |   |..|||||||.||.|||
pdk...kviyG..kitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtf

CLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEgaKFIMGDSSVQDQ
.  |. |   |. .    .|. ...  .|. |....|.|.| .| | |..|   |. ||.|. ..
itldavl...dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle..tfvcgdtsiaqd
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 28-276 1.3e-61 203.2 In-house 12-266 (274) alignment 
Range on Protein: 28-276
Range on HMM: 12-266/274.0
SDFPCRV----AKLPKNKNRNRYRDVSPFDHSRIKLH-----QEDNDYINASLIKM-EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKG
 . |  .     ........|||... | ..||. |.     .|| .||||  ||  .| .. |. ||||||||   ||.|....... .||| .. |. 
lelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkean

SLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTqeTREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEH-GPVVVHCS
  |||.|.|..|. |.  . ......  .   .  |.||.| |..|.   .|.. |. || |||  .|... ..|... .|.|| . . .. .|||||||
eqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCs

AGIGRSGTFCLADTCLLLMDKrkdPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
||||| | |  .. ..  ...    . ||. |.  ..|  | |..||..| .. . |...
aGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPRA_pd Subfamily PTPRA 32-286 6.7e-61 201.0 In-house 50-301 (330) alignment 
Range on Protein: 32-286
Range on HMM: 50-301/330.0
CRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQ
. .|.  .||..||. .. |.|.||. | .    |. |||||| |.  . . ..| .|||. .|   || |.|||||  .|||  . |.   |||||||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

KEekemIFEDTNLKLTLISEDIKSYYTVRQLELENLT----TQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEhgPVVVHCSAGIGRSG
.     ..   |.....  | .   ||||.. ...|.     ...| .  ||.|.|||.|||  |   |..| ||..    | .  |.|||||||.||.|
eG....lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtG

TFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEgaKFIMGDSS
||.  |. |   .. |    ||. ... ..|. |  ..||  |  | | .. |   .. ||. 
tfivldavl...ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle..yylygdte
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 34-289 2.8e-60 199.3 In-house 55-302 (319) alignment 
Range on Protein: 34-289
Range on HMM: 55-302/319.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNrvmekgSLKCAQYWPQKE
 | |..||..||. .. .||....||..    |  |||||| ..    .  || .||||.||   || |.||...  .|.|         ||.||||.| 
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

EKEmiFEDTNLKLTLISEDIKsyYTVRQLELEN-LTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLA
...   |  ..|.... |  .  |.||..|| .    .. |.|  ||.  ||| |||..|. .. .. |||   |   .. ..|||||||.||.|..   
vik..eerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivl

DTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQD
|.   |.|. |. . ||. ... ..|. |  |.|   |  | | |..|   |   | .. |
dv...lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 34-289 1.1e-59 197.3 In-house 19-266 (284) alignment 
Range on Protein: 34-289
Range on HMM: 19-266/284.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNrvmekgSLKCAQYWPQKE
 | |..||..||. .. .||....||..    |  |||||| |.    .  || |||||.||   || |.||...  .|.|         ||.||||.| 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

EKEmiFEDTNLKLTLISEDIKsyYTVRQLELEN-LTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLA
...   |  ..|.....|  .  |.||..|| .    .. |.|  ||.  ||| |||..|. .. .. |||   |   .. ..|||||||.||.|..   
vik..eerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DTcllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQD
|.   |.|. |. . ||. ... ..|. |  |.|   |  | | |..|   |   | .. |
dv...lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd
subfamily_PTPRN_pd Subfamily PTPRN 15-281 5e-59 194.4 In-house 34-295 (297) alignment 
Range on Protein: 15-281
Range on HMM: 34-295/297.0
SWAAIYqdiRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEE-AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVM
 | |.    ..|| .  . ||| .|| ..||...| |.||||.||..|    ..|||||| |  ..  . .|| |||||..|  .||.||||| .  .|.
ewealc...ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LNRVMEKGSLKCAQYWPQKEEKemIFEdtNLKLTLISEDIKS-YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgsLSPEH
| |. |.|  .|..|||.. ..  ...    .. |.|| | .  | || . | || |.||| .  ||. .||. ||| |. |.|.|  ||  |       
ltrleeegvkqckrywpdeGse..vyh..iyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks..yrGrs

GPVVVHCSAGIGRSGTFCLADTCLLLMDkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFI
 |.|||||.| ||.|...| |  |  .   |    .||   |  .|  | ||..| ||..| . ||.|  . |
cpivvhcsdGaGrtGvyilidlvlnrll..kGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 18-277 2.3e-58 192.4 In-house 24-282 (290) alignment 
Range on Protein: 18-277
Range on HMM: 24-282/290.0
AIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QED--NDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLN
. .. .   .|..   |.  ..||..||.... . |  || |.    ..|  |.||||. ||  . ...||.||||..||  .||...|..|.  .||| 
nqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmlt

RVMEKGSLKCAQYWPQKEEKEmiFEDTNlkLTLISEDIKSYYTVRQLELENLTT-QETREILHFHYTTWPDFG-VPESPASFLNFlfKVRESGSLSPEHG
 ..|.|. || ||||... |.  ..  .  ..|..| . ..|. |.||..| .. ...... ... |.|.. | |..  .. | .  . ..     .  .
niieegkvkCqqYWpdsdtka..ygefs..ikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi..eemyktqrkrgnt

PVVVHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
..|||||...|||..|| |.| .   .| |    .|. .|| ..|  ..|..||..|... .  |.. 
sivvHCSdtvgrsavfcaaatti...nkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 28-277 6.1e-57 187.8 In-house 32-276 (315) alignment 
Range on Protein: 28-277
Range on HMM: 32-276/315.0
SDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQ
  .. |||. . | ..|||... |.|..|.||     . |.|||||| ||  . ...|| .||||. .   ||.||...|   .||..   |   .||.|
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPQKEEKEMIFedTNLKLTLISEDIKSYYTVRQLELENltTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgsLSPEHGPVVVHCSAGIGRSG
|||... . . |   ..|..|.| .  .  ..|.| . .  ..|.| .  |..| ||| ||..  .|.|... .|. .    ... ...||||||.||.|
ywPdrkadsvef..Gsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtG

TFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
 .. .| ..   .. |. .|||. ... ..|. |. |.|| ..  | | || | 
vvisidevv...aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 38-276 1.2e-55 183.6 In-house 45-276 (287) alignment 
Range on Protein: 38-276
Range on HMM: 45-276/287.0
PKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEkeMIFED
..||..||.... . |  |. |..|..|||||. |.  . .. .|....|. ||   ||.......   .||| . .|.   .| ||||...   ... .
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

tnLKLTLISEDIKSYYTVRQLELENLT-TQETREILHFHYTTWPDFG-VPESPASFLNFLFKVREsgSLSPEHGPVVVHCSAGIGRSGTFCLADTCLllm
   ...|..|.... |..|.||..| . .......  ...|.|.. | |.|  ...| .  ....     . ....|||||...|||..|| |.| .   
..yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..qrkrgntsivvhCsdtvGrsamfcaaatti...

DKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
.| |    .|. .|| ..|  ..| .||..| .| . .|.|
nkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 17-275 7.4e-55 180.8 In-house 17-274 (287) alignment 
Range on Protein: 17-275
Range on HMM: 17-274/287.0
AAIYQDIrhEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE---DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRV
 |. .|   |.| .  . |.   . ..||| || |.|..|. | .|     |||||  .   . . ..| .|||.. | . || .|.|..|  |... | 
dalkeds..esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

MEKGSLKCAQYWPQKeEKEMIFEdtNLKLTLISEDIKS-YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKV---RESGSLSPEHG
.|.. ||| .|||.. |. |        ..|.. |||.  |.|| | | .| |.|.| .  ... .||| ... .  ... | ..|    |    . | |
veearlkcykywPer.evPmrvG..GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PVVVHCSAGIGRSGTFCladTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
|.|||...||||||..    . | |... .|   ||. .|.. .|..| .|.|.. |||..| |..
PlvvhddvGiGrsGill...atlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 32-278 2e-54 179.9 In-house 40-288 (325) alignment 
Range on Protein: 32-278
Range on HMM: 40-288/325.0
CRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNrVMEKGSLKCAQYWPQ
 .|| .|.||..||...| ..|.||. |       . |||||| .. .  .  .. .| ||..| . .| .| . ..  ||.|| ....|  .||.|||.
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavywpk

KEEKEMIFEDTNLKLTLIsEDIkSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVR---ESGSL-SPEHGPVVVHCSAGIGRSG
.  |   |   ..||  | |.| | |  |.|.. .    ||| .  |.. .|.|.||.. ||.....|  |    |     .   .|..||||||.||.|
emgksktfGglevklrti.eei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

TFCLAdTCllLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGA
.|     .  ...|  . |.||| ...  .|| |  ...|.||  . | |..|  
vfisl.ys..alakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0041856 (Phosphotyrosine protein) phosphatases II 40-281 3.4e-54 178.5 In-house 1-174 (182) alignment 
Range on Protein: 40-281
Range on HMM: 1-174/182.0
NKNRNRYRDVSPFDHSRiklhqeDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNrvmekgslkCAQYWPqkeekemifedtn
|...|||.|. |.||||      |.|||||.|. .   .. .|.|||||..|. .|..|..|.. . .|.|.         . .|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

lkltlisediksyytvrqlelenltTQETREILHFHYTTWPDFGVPEsPASFLNFLFKVREsgslspEHGPVVVHCSAGIGRSGTFCLADtcllLMDKRk
                         . ..|......|. |||.|||. . ..|.|. .|.|      |.|||.||||||.||.||...|.    || |. 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkkl.

dpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFI
   .|.. ... ..|. |.| ..| .|..| .||. |  .. 
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 29-277 1.5e-52 173.4 In-house 32-275 (515) alignment 
Range on Protein: 29-277
Range on HMM: 32-275/515.0
DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY
 .|  ||.   | ..|||... |.| .|.||     . ..||.||| |.  .....|| .|||.. .   || .|....   ..|...  |    ||..|
iypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky

WPQKEEKEMIFEdtNLKLTLISEDIKSYYTVRQLELenLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPeHgPVVVHCSAGIGRSGT
||.|  . . |   ..|. |.| .  .  . |.|..  |  ...| .  ||.| ||| |||.   |.| .. .|. . .    | |...|||||.|| | 
WPdkpgdsvkfG..sikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.h.pliihcsaGvGrtGv

FCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
.. .| ..    . |.  .||. ...  .|. |. |.|| .|  | | || | 
visidsvv...ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 27-284 1.2e-50 167.0 In-house 20-270 (283) alignment 
Range on Protein: 27-284
Range on HMM: 20-270/283.0
ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIK---MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQ
  | .. .|   .||. ||.... | |  |..|. | .|||||. |     .. .. || .|.|| .|   || ||...|   .||| ...|    ||.|
vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPQKEEKEMifedTNLKLTLISEDIKSYYTVRQLELENL-TTQETREILHFHYTTWpdfgVPESPASFLNFLFKVRE--SGSLSPEHGPVVVHCSAGIG
|||..  ..      .. .||  |  .  .....| | .  ....|  . |. .  |    .  .. . .| | |.    |     ..||.|||||.|||
yWPkrGsedy....GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiG

RSGTFCLADTClllMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAkfIMGD
|...|. | .    ... .  | ||. .|.  ||. ||...|| || .. . .|.| |  . ||
rtavfiaasas...vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa..lcgd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 29-276 1.5e-49 163.8 In-house 40-282 (297) alignment 
Range on Protein: 29-276
Range on HMM: 40-282/297.0
DFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEEAqrSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSlKCAQY
 .|  ||.   | ...||... |.| ||.||.      | ||.||| .|  .    .| || | ..|   || ||....   .||||   |.   |||.|
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPQKEEKEmiFEDTNLKLTLISEdiKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPE--SPASFLNFLFKVRESGSLSPEHgPVVVHCSAGIGRS
|..|  ..  | |  ..|. .||  .. .  |.||...  .. .| .  .... |||  |..  | .|.|...  ||.. |   |  |..|||.||.|| 
Wsdkgvtt..fGdvsvvllsvse..reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrt

GTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
| ..  | ..    . |.  .||| ...  .|. |. |.|| .| .| | ||.|
gvlltidsvv...aeakrekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 39-275 1.6e-49 163.3 In-house 2-236 (237) alignment 
Range on Protein: 39-275
Range on HMM: 2-236/237.0
KNKNRNRYRDVSPFDHSRIKLHQ--EDNDYINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIf
.|| .||| ..  .||||. |.    . |||||. .| .. . ..|| .|||| ..|  ||.|||..|   .|||  ..|.  ||| .|||. .. .   
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay.

edTNLKLTLISEDIKSYYTVRQLELE-NLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLll
    | ..|  ..  | |||| | |  .|| .| | |  ...|.||| |||.  |..| |  .. .     .| || ..|||||.||.| | . |. |  
..gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml..

mDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
  . |.   ||| . .  . . |  .||| ||  | . ...
.rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0049772 (Phosphotyrosine protein) phosphatases II 28-289 2.5e-47 157.5 In-house 34-291 (314) alignment 
Range on Protein: 28-289
Range on HMM: 34-291/314.0
SDFPCRVAKLPKNKNRNRYRDVSPFDhSRIKLHQ---EDNDYINASLIKMEeaqRSYILTQGPLPNTCGHF----------WEMV--WEQKSRGVVM---
... . ||.|..|...||| |. |.| .| .|.    .. |||||| ..     ...| |||||..|.  |          |.||  .....| .||   
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LNRVMEKGSLKCAQYWPQKEekemifedtnlkltlisediksY-------YtvrqlelenlttqeTREILHFHYTTWPDFGV
                  |......|.. .|..... .                              .              .|........ .||...
evladelsrLdaAlgKtpllildgngneptaadlellk......................eelydpelf..............erlgikylripvpDgsa

PeSPASFLNFLFKVRESgslsPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDkrkdpssVDIKKVLLEMRKFRM-----GLIQTADQLRFSYLAVIEGAK
| ... |. ||  ..|     ...|||.|||.||.||.|||..|. ...|..       |.....| ..|. |.     |.|.. .|. | . |. |  |
p.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRpinpnpgfieqleqyefilealleylk

FIMGDSSVQD
|... ... .
flkkfyeyle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 5-287 1.5e-46 153.7 In-house 9-286 (439) alignment 
Range on Protein: 5-287
Range on HMM: 9-286/439.0
KEFEQIDKS--GSWAAIYQDIRHEASDFPCRVAKLPK--NKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFW
.  |..||     .  |.. |     |. |  . . .  .. .|||.||..|||.|. |.         ||||  ||    .. || ||||  .|. .||
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfw

EMVWEQKSRGVVMLNRVMEkgSLKcaqYWPQKEekEMIFEDTNLKLTLISEdiKSYYTVRQLELEN--LTTQETREILHFHYTTWPDFGVPESPASFLNF
 .|.|.|.  .|||  ..|  | |   ||| ..  |... |  ..     |     |..| . . |   ||.  | .|.|||..|||  ||   .  |.|
rlviekktvtivmltnlve..syk...ywpsda..evcygdiavrvdrnie..lpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LFKVrESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFimGDSSV
|  . .|   . | ||||||||||.||.||    | .|   .. |    |||| ..  .|| |  ..|.  |  | | ||.|  ..  || .|
lrai.nsandkeeygpvvvhcsagvGrtGtiialdial...eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy..Gdiav
0051429 (Phosphotyrosine protein) phosphatases II 64-280 1.7e-45 151.1 In-house 4-227 (272) alignment 
Range on Protein: 64-280
Range on HMM: 4-227/272.0
NDYINASLIKMEeaqR------SYILTQGPLPNTCGHFWEMvWEQKSRGVVMLNRVMEKGSLKCAQYWP--------QKEEKEMIFEDTNLKLTLISEDI
..||||. ...            .....||||.|. .|| . .|.. . .|.| ...|.|.||| .|||          .. ..  .  .| .||.|| .
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

KSYYTVRQLELENL-TTQETREILHFHYTTWPDFGVPESPasFLNFLFKVREsgslspeHGPVVVHCSAGIGRSGTFCLADTCLLLMdkrKDPSSVD---
...|..| |.|..| ...|.||..|.||| |||.|||...  .|..|  ...       .|||.||||||..|.||..... .|| .    .   ||   
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgv...sletivddYl

-----IKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
     . ... |.|. |.| .|| .|..| | |..| .. 
ltnlyleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 64-269 1.3e-44 147.3 In-house 2-161 (174) alignment 
Range on Protein: 64-269
Range on HMM: 2-161/174.0
NDYINASLIKMEEAQRSYILTQGPLPntcghFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQkeekemifedtnlkltlisediksyytvrqlelenL
.|||||| ... .  . .|..||||.     ||||..|.... ||||.. .|.|. || .|||                                    |
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

TTQETREILHFHYTTWPDFGVPESPAsFLNFLFKVRESGSLsPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDkrkdPSSVDIKKVLLEMRKFRMGLIQT
 . ..|......|. |||.|||...  .|.|.  |.|  |  ...|||.||||||.||.||...|. .| ..     .| ||. ... |.|. |.| .||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqt

ADQLRF
 .|.||
psQyrf
subfamily_CG7180_pd Subfamily CG7180 31-274 1.6e-44 146.8 In-house 33-286 (296) alignment 
Range on Protein: 31-274
Range on HMM: 33-286/296.0
PCRVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSlKCAQYWP
 |. .   .|...||. .| |.|. |. |.    .|..|||||. .     .. || |..|  .| . ||..|.....  ||.| ....    .. .|||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

QKE---EKEMIFEDTNLKL--TLISEDIKSYYT-VRQLELENLTTQETREILHFHYTTWPD-FGVPESPASFLNFLFKVRESGSLS---PEHGPVVVHCS
.|     .|.. | .. |    | .  .| . . |   | |.  . ||| ...|..|.|.    || | ....... .||         ||.|||||..|
nkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

AGIGRSGTFCLADTCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAV
 | .||| .. .| .| |..| .    ||. . .  .|. | .|... .. .. |  .
dGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 35-276 2.1e-44 146.5 In-house 2-238 (239) alignment 
Range on Protein: 35-276
Range on HMM: 2-238/239.0
AKLPKNKNRNRYRDVSPFDHSRIKLHQEDN----DYINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE
||   || .||| ..  .||||. | .  |    |||||| ..  . . ..|| ||| .  ..| || |.|...   .|||  ..|    || ||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EKEmifedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgSLsPEHGPVVVHCSAGIGRSGTFCLAD
 |       ||..||   .. . | .| . . ..   | | . ..|.| ||| |||.  .. | .  |. .  || |   | |.|||||.||.|.| . |
sky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaflvid

TCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
. |    |.|   .||| . .  .|. |  ..||..|  | .|||.|
amlrqakkqk...tvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 35-276 2.6e-44 146.2 In-house 3-239 (239) alignment 
Range on Protein: 35-276
Range on HMM: 3-239/239.0
AKLPKNKNRNRYRDVSPFDHSRIKLHQEDN----DYINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE
||   || .||| ..  .||||. | .  |    |||||| ..  . . ..|| ||| .  ..| || |.|...   .|||  ..|    || ||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EKEmifedTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgSLsPEHGPVVVHCSAGIGRSGTFCLAD
 |       ||..||   .. . | .| . . ..   | | . ..|.| ||| |||.  .. | .  |. .  || |   | |.|||||.||.|.| . |
sky.....cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaflvid

TCLLLMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
. |    |.|   .||| . .  .|. |  ..||..|  | .|||.|
amlrqakkqk...tvdifnyvkairedrphmvqtseqyvfihlavle
0046846 (Phosphotyrosine protein) phosphatases II 57-275 2.8e-44 146.3 In-house 5-170 (176) alignment 
Range on Protein: 57-275
Range on HMM: 5-170/176.0
IKLHQEDNDYINASLIKMEEaqrsYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMifedtnlkltlisediksyytvr
.  ...| |||||.|| .      .| ||||||.|. .|.||..|.. . ||.|.  .|.|.|||..|||. |. ..                       
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

qlelenlttqetreilHFHYTTWPDFGVPESpASFLNFLFKVRESGSLSpehGPVVVHCSAGIGRSGTFCLADtcllLMDKrkdPSSVDIKKVLLEMRKF
                ..... |||.|||.. . .|..|  .||  .     |||.|||||||||.||...|.    |. .      ... ..| ..|. 
................qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreq

RM-GLIQTADQLRFSYLAVI
|. | .|| .|.|| | .. 
RplgavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 62-271 1.1e-43 144.2 In-house 3-154 (172) alignment 
Range on Protein: 62-271
Range on HMM: 3-154/172.0
EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelE
|..||||||....    ...| |||||.||. .||.|..|.. . .|.|..                                                .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

NLTTQETREILHFHYTTWPDFGVPeSPASFLNFLFKVRESGsLSPEHGPVVVHCSAGIGRSGTFCLADTCLllmdkrkdpSSVDIKKVLLEMRKFRMGLI
.......|......|. |||.||| ... .|.||  ..|   .  ..|||.||||||.||.||...|. .|          .... ... ..|. |.| .
ydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgav

QTADQLRFSY
|. .|.|| |
qnpsqyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 40-266 3.2e-43 142.5 In-house 54-271 (290) alignment 
Range on Protein: 40-266
Range on HMM: 54-271/290.0
NK--NRNRYRDVSPFDHSRIKLHQ-EDNDYINASLIKMEEAqrSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFE
|   ..|||.||   | .|. |..  | ||. |  .|  .|   .|||||.| .|   .| || ..|   .|||  ..|.|  ||.||.|.|| . . | 
ntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DTNLKLTLiSEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslspeHGPVVVHCSAGIGRSGTFCLADTCLLLMD
.  .  .. ..|  .    . | . .  .     . |..  .|||  |. |  ..|  |. .|.        |||||||||||||.|||   ...| .. 
eitvlcse.eddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqill

KRKDPSSVDIKKvllEMRKFRMGLIQTADQ
. |.   .|. .    .|. |.. .|   |
dGkeldlldlvr...alrnsrlnsvqvdiq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 37-275 1.5e-42 140.5 In-house 45-284 (305) alignment 
Range on Protein: 37-275
Range on HMM: 45-284/305.0
LPKNKNRNRYRDVSPFDHSRIKLHQE-DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIF
  .....|||.||  .|. |.||.     .|| |  .      . .| || || .||  || | ...|   . ||  ..|||. ||..|.. |..... |
eaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

EDTNLKLTLISEDIKSYYTVRQ---------LELENlTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVResgslsPEHGPVVVHCSAGIGRSGTFC
|. . |...  |  ...  ...         | .|  . ...| . |.|.  ||| ||| .  . |..| | |      | .||.||||||||||.|.  
eekgqkisvkfessvtlkfrkdakakvtetvlvieg.pgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtgsvv

LADTcllLMDKRKDPSSV-DIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
. .    ..|.      . | .|.|  .|. |   ||| .|  | .  ..
mley...ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 14-272 9.1e-42 137.8 In-house 15-287 (301) alignment 
Range on Protein: 14-272
Range on HMM: 15-287/301.0
GSWAAIYQDIRHeASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDN------DYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGV
 . .. |..... ..| .| |    .||. ||.......|. || |... |      .||||| |.    .. .| .|||. .|   || ..|..|   .
nkfeeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLNRVMEKGSLKCAQYWPQKEEKEMIFedTNLKLTLISEDIKSYYTVRQLELE---------------NLTTQETREILHFHYTTWPDFGVPESPASFL
||.    |.   || ||||. |...  |   ... ||..| .   ...||| .                  ........| .. | ||. ||   |.  |
vmvtnlkegtkskceqywpnseaeseef..gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

NFLFKVRESgSLSPEHGPVVVHCSAGIGRSGTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYL
. . .|      ... ||||||||....|||..|  .  |   .  |    ||. .|   .|. ..| ..| .|  . | 
qviddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsigl...EQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 36-267 1.7e-40 134.0 In-house 37-266 (307) alignment 
Range on Protein: 36-267
Range on HMM: 37-266/307.0
KLPKNKNRNRYRDVSPFDHSRIKLHQ--EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEM
 .  | ..|||.||   |..|| ..      ||| |  . .    . .| .|||| ||  .|| |. ..|   |.|| .|.| . .|| |||| .| ...
afsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

IFEDTNLKLTLISEDIKSYYT----VRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgslspEHGPVVVHCSAGIGRSGTFClad
.| ...  ...    .|        .   .|.   .|..| | |. .. ||| |||.   . .|.|  ||       .. |||||||||.|||||     
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvGrsGtiv...

TCLLLMDKRKD-PSSVDIKKVLLEMRKFRMGLIQTADQL
.  |..||  .     |.||.. |.|. |   |||  | 
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 21-276 7.8e-40 131.6 In-house 14-293 (297) alignment 
Range on Protein: 21-276
Range on HMM: 14-293/297.0
QDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ--EDNDYINASLIKM--EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK
. . .||      .|| .    .|||||.  .| .|.|| .   ..|||||  . .  |||.  |||.|||| .|   ||..|.||  | .||. .. | 
dllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqed

GSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVP---ESPASF----------LNFLF-------
|  ||| |||. ... .   |  . .  .|.    . .|   ||. .  .|.| . |  . .||| |||   |    |          . ...       
Grdkcapywpsvvqerlkagd..vvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemft

-----KVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPssvDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
     ..    .  |   ...||||||.||||   |.|. |  . |.. |   |.. .|  .|. |  |.|| .|  . | ||..
amvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 23-276 2.3e-39 130.0 In-house 18-257 (267) alignment 
Range on Protein: 23-276
Range on HMM: 18-257/267.0
IRHEASDFPCRVAKlpKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKgslKCA
| .. |   . .|.  ||..|||. |. |.|..|. | .....||||| ..  . .. .|.||.|| || ..|.... .||   .|.| .| .    .  
isdtsstisqsiae..knqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nir

QYWPQKEEKEMIFEDTNLKLTLISEDikSYYTVRQLELEnLTTQETREILHFHYTTWpdfGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRS
..|| |  .   ..|  .. .|  |.    | .  |||. .  . ....  ..|  |    .      .|. || .     |     |.||.||.|.|||
lfwPPkmgqakkyqdltvehslekee..ndyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrs

GTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|||  .|. |   .. |  . .|| . |...|. |.||..| ..  . .  . |
Gtflvidsql...eraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 28-277 3.6e-39 129.3 In-house 33-235 (392) alignment 
Range on Protein: 28-277
Range on HMM: 33-235/392.0
SDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKL----HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGslkcaq
  .| .||. . |...|||... |.| .|.||       |.||.||| |.  .....|| .||| . .   ||.||....   ..|.... |        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpqkeekemifedtnlkltlisediksyytvrqlelenlTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVR-ESGSLSpeHgPVVVHCSAGIGRS
                                          ...| .  ||.| ||| .||.  .|.|.|. .|. . |. .  | |...|||||.||.
........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..h.pliihcsagvgrt

GTFCLADTCLllmDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
|     |. .    . |    ||. ... ..|. |  ..|| .|  | | ||.| 
gvvisidsvv...ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0049260 (Phosphotyrosine protein) phosphatases II 79-271 3.7e-39 129.2 In-house 9-143 (152) alignment 
Range on Protein: 79-271
Range on HMM: 9-143/152.0
RSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilHFHYTT
. .| ||||.|||. .||.|..|.. . .|||.. .|.| |||.||.                                               ..... 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlp

WPDFGVPESPASFLNFLFKVRESgsLSPEHGPVVVHCSAGIGRSGTFCLADTCLllmdkrkdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
|||.|||...  .| .|  ...   .  ..|||.||||||.||.||...|. .|           |......  .|. |.| ... .|||| |
wpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 31-284 9.1e-38 124.8 In-house 26-273 (285) alignment 
Range on Protein: 31-284
Range on HMM: 26-273/285.0
PCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEE-AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE
 |  .    | . ||| ||   . .|. |.. | ||| || ..|    | .|| ||||||.|   || |....|   |.||  ..| |  ||| |.|.| 
nctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

EKEMIFEDTNLKLTLISEDIKSYYTVRQLELENL--TTQETREILHFHYTTWPDFGVPESPASFLNFLFKVResgSLSPEHGPVVVHCSAGIGRSGTFCL
 . . |   .. ||   |.  .   .  | . |   .. |   . | .   |||   ||    ....   |.    . |.  |..||||||.||. ||  
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk...kvnpkekpicvhcsagvgrtatfvg

ADTCLLLMDKRkdPsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEgakFIMGD
 | . . . .   |  ...  .. ||| .|.  .|.  |. | |. ..|   ...|.
idyatirimen..p.niemldivremramrfqavqshmqflflyvvlme...yfige
subfamily_ptpA1_pd Subfamily ptpA1 39-231 1e-36 121.6 In-house 46-252 (418) alignment 
Range on Protein: 39-231
Range on HMM: 46-252/418.0
KNKNRNRYRDVSPFDHSRIKLH----QEDNDYINASLIKMEEaQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE--EKE
.| ..||| .. | .|.|..|.    .| .|||||  |      . .| ||||||||   || ||||.. | .|||.|  |.  .|| .|||..   |. 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

MIFEDTNLKLTLISEDIKS-------YYTVRQLELenLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGS----LSPEHGPVVVHCSAGIGR
 |. . |  .   | ..             |.. |      |||.| ...|  |||. .|.    | ..|. . .        |    |..||||||.||
siygngnevfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

SGTFCLADTC
.|||| |   
tgtfctavim
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 29-266 1.7e-36 120.3 In-house 27-257 (281) alignment 
Range on Protein: 29-266
Range on HMM: 27-257/281.0
DFpCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ-----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQ
|. | | . | |...||| ..  .| ||..|.      .  ||| |  |.    .| |||||||  .|   || |.|....  .||| ...|    |||.
dl.ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPQKEEKEMIFEDTNLKLTlISEDIKSYYTVRqleLENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlspehgPVVVHCSAGIGRSG
|.|..    . |.   ..    |   ||  | |   |.     ||| | |. .  |||. ||||   .|. | |.|   .      | |.|||||.||||
yfprnahcclqfdklsvsye.dstvnkslvttr...lnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarst......ppvihcsagvgrsg

TFCLADTCLLLMdkRKDPSSVDIKKVLLEMRK-FRMGLIQTADQ
|.   . .|  .  .   .  |||...  .|   |   .|| .|
tlmaveialqsi..hshftlpdikqivshlrvtgraasvqtlqq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 35-276 1.2e-35 117.9 In-house 38-269 (288) alignment 
Range on Protein: 35-276
Range on HMM: 38-269/288.0
AKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMI
 .  .|  |.||...   | .|.||. . . ||.| ..  .. .|  | .| ||  | . .|.|. |.  . .|||....|||  | |.|.| |  ... 
dsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FEDTNLKLTLISEDIKSYYTVRQLELENltTQETR-EILHFHYTTWPDFGVPESPASFLNFLFKVresgslSPEHGPVVVHCSAGIGRSGTFCLAdtcLL
.           .||.   .|  |  ..  . |..  . . |.  |.| ||||.  |.|..|  .         . |.|||.|||.||.||. |    |.
igrlctvvkkkradidklvkvsllrisk..egeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlili...li

LMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
 ..  . .  . |...| ..|. |.  |||  |  . .  | |
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
0051082 (Phosphotyrosine protein) phosphatases II 63-274 1.4e-35 117.4 In-house 2-149 (151) alignment 
Range on Protein: 63-274
Range on HMM: 2-149/151.0
DNDYINASLIKMEeaqrsYILTQGPLPntcgHFWEMVWEQKSRGVVMLNRVMEKGslKCAQYWPQKEekemifedtnlkltlisediksyytvrqlelen
 .||||.| .        .....|||.    .|.|...|.. . .|.|.  .| |  .|..|.|. .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

lttqetREILHFHYTTWPDFGVPESPASFLNFLFKVREsgslsPEHGPVVVHCSAGIGRSGTFCLADTCLlLMdkrkdpssVDIKKVLLEMRKFRMGLIQ
      .|.||.... |||.|.|.|....|.|| ....     ...|||.||||||.||.||..... .| |.        |.. ..| |.|..|.|..|
......ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml.lg........vsleealeeyrlkrpgvvq

TADQLRFSYLAV
. .| .| ..|.
pnqqflfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 35-270 2.1e-34 113.7 In-house 47-273 (301) alignment 
Range on Protein: 35-270
Range on HMM: 47-273/301.0
AKLPKNKNRNRYRDVSPFDHSRIkLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMI
| |||.|.|       |    .. . .     | |  |. .   . .| |||||.||.  || |.   .   .||| . .||   ||..| |.| .... 
aylpkdkhryptvPckPstavev.ivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

FEDTNLKLTLISEDIKSYYTVRQLELENLTTQ-ETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslspeHGPVVVHCSAGIGRSGTFClaDTCLL
 .  ..|..     ..   . |.||.|. | . .|| ..|. |..|.| |||.| |   ...  |..|      . |.||||||||||| .|    |  |
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks......ekPivvhcsaGiGrsvafi..gteyl

LMDKRKDPsSVDIKKVLLEMRKFRMGLIQTADQLRFS
  .   ||  ..... | ..|. |   .||  || . 
areveadp.tieltealkhlrehrwngvqtnsqlywm
PTPc_DSPc_SM00012 171-275 1.1e-33 111.0 In-house 2-104 (105) alignment 
Range on Protein: 171-275
Range on HMM: 2-104/105.0
ILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpSSVDIKKVLLEMRKFRMGLIQTADQLRFS
. |.|||.|||.||||.. |.|..| .|... . | ...|||||||||.||.|||...|..|  ..|..  ..|||.... |.|| |.|..|| .|  | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YLAVI
| |..
yrall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 40-257 1.3e-33 110.9 In-house 55-271 (305) alignment 
Range on Protein: 40-257
Range on HMM: 55-271/305.0
NKNRNRYRDVSPFDHSRIKLHQE-DNDYINASLIKMEE-AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE-EKEMIFE
.. .|||.||   |.| .||..    ||| |  .      .. .| .|||| .|  .|| || ..|   .||| . .| | ||||||||    ||  .  
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks

DTNLKLTLISEDIKSYyTVRQLELENLTT--QETREILHFHYTTWPDFGVPESPASFLNFLFKVRESgslspeHGPVVVHCSAGIGRSGTFCLADTCLLL
   ..    |  ..   .  |. | |||   ...  . |...| ||| |||    . |..|  .| |      . |.||||||||||.||    .  |  
givvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs......kvpivvhcsagigrtgtivaieyilek

M-DKRKDPSSVDIKKVLLEMRKFR
. .... |   .. | | . | | 
iaenkpcppmpelvkalrdqrafs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 37-276 1.3e-32 107.8 In-house 40-274 (312) alignment 
Range on Protein: 37-276
Range on HMM: 40-274/312.0
LPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQK-----EEK
. | |. ||| ..  .|  |. |  ..| || | ..|.      .. ||||| ||| |||...    |  ...|  ..| || |||.|  .       | 
flkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

EMIFEDTNLKLTlISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgslspEHGPVVVHCSAGIGRSGTFCLADTC
  .. .   ..  |    |   | | | .   .| .   . |. ...||| |.|.|  . | .|  |.       .. ||. |||||.||.||..| .. 
hrvyteycteie.iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesm

LLLMdkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
.  .   . |   ..|.... .|| |   ...  |  ..  .|.|
iaal...rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_CG42327_pd Subfamily CG42327 38-203 1.5e-32 107.5 In-house 26-196 (319) alignment 
Range on Protein: 38-203
Range on HMM: 26-196/319.0
PKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKE
.  |...|. .| |. ..|. |..    . . |..|| ..  ..|. ||| .| .| ..   || .||||.|| .| |  . |.|  .||.|.| ||  .
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

MIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYtTWPDFGVPESPASFLNFLFKVRES-GS
      ....||   ..|  | .  | | ..  .|.||. |. |  |.. .|| ..|...  |..||.|  |
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
0044763 (Phosphotyrosine protein) phosphatases II 52-269 5.3e-32 106.3 In-house 2-162 (178) alignment 
Range on Protein: 52-269
Range on HMM: 2-162/178.0
FDHSRIKLHQEDN----DYINASLIKMEeaqrsYILTQGPLPntcgHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEkemifedtnlkltlise
.|..| .|.   .    |||||| |        ..|.. | .    ...|...|.. . .|.|.  .| | ||| .|||....                 
ldrtrvllsnleglersdyinaseilpg.....lylgslppa....ddlellkelgithivnlteelelgflkcdpywpeeag.................

diksyytvrqlelenlttqetreiLHFHYTTWPDFGVPESPASFLNFLFKVRESGSlsPEHGPVVVHCSAGIGRSGTFCLADTCLLLmdkrkdpsSVDIK
                        ...... .||.|||.... ||.|.  ..|  .  ...|||.||||||.|||||...|. .. |        .... 
........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl........glsle

KVLLEMRKFRMgLIQTADQLRF
... ..|. |.  ... .|||.
eaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 39-272 2e-29 97.2 In-house 51-282 (310) alignment 
Range on Protein: 39-272
Range on HMM: 51-282/310.0
KNKNRNRYRDVSPFDHSRIKLHQE---DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMI-
|.  .||| ||   | ||.||. .    .||| |  .| .  . ..| .||||  |   || |......  ...| .|.|.|  ||  |||     |   
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

-FEDTNLklTLISEDIKSYYTVRQLELENLTTQETR------EILHFHYTTWPDFGVPESPASFLN--FLFKVResgslspeHGPVVVHCSAGIGRSGTF
    |||  .  ||...       .  .|.  .|         .   ..  ||| |||.     .   .| .||        |||.|||||||..| .. 
cirvtnl..sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr........hgpcvvhcsagkdrlyvv

CladTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQlrFSYL
.   .  | .|| .    ||...|  |..| |.  |||  |  . ..
v...alklkidkldrglkvdaeevktellksraiciqtelq..ylii
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 28-276 6.7e-29 95.5 In-house 33-277 (303) alignment 
Range on Protein: 28-276
Range on HMM: 33-277/303.0
SDFPCRVAK--LPKNKNRNRYRDVSPFDHSRIKLhqEDNDYINASLIKMEEaQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYW
| .| .|.|  . || ..||. ||  .|||..||   |  || || ....  ..  |||| ||. |.  ||.|. ||| . |..|    |  .|     .
sylppsvsknqfvknmdknrfvdvicldhskvkl..sdssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PQKEEkEMIFEDTNLKLTLIS-EDIKSYYTVRQLELENLTTqetREILH-FHYTTWPDFGVPES-PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRS
|....  . ||.  ...  .   ..   .... | . | .    . .||  || .||   .|    . |.. .....       .  | |    .| ||.
prnqd.flkfeersirvgefkrvelgdgwvlkvlsvsngdy...ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgra

GTFCLADTCLLLMDkrKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
|||.| .|. | .   .. .|.|. |.|  .|. |.  .|   |. . |  . |
gtfalfetahlslh..seqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 77-293 6e-28 92.6 In-house 33-233 (255) alignment 
Range on Protein: 77-293
Range on HMM: 33-233/255.0
AQRSYILtqgplpnTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIksYYTVRQLELENLTTQETREILHFHY
 . .|.|       |  .|....  .|.  ||||    |.|  || .|.| . .. ....| |.  |  | |.      ... ..    ..|... |..|
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadv..vlrtleitstlgekkkthtvkhysy

TTWPDFGVPESPASFLNFLFKVRESGSlspehgpVVVHCSAGIGRSGTFCLADTCLLLMDK---RKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLA
. |..   || .   || |  ||.| |       ||||||.||||| .| ||.     | .   . .   .| ...| |.|. | . |.|  || || | 
kGWieknaPelareilnilkvvrdsks.......vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilm

VIEgakFIMGDSSVQDQWKE
|..   ..   . ......|
vld...lvfpkgeleakyqe
0048076 (Phosphotyrosine protein) phosphatases II 144-274 4.9e-26 86.5 In-house 25-139 (145) alignment 
Range on Protein: 144-274
Range on HMM: 25-139/145.0
LISEDIKSYYTVrqlelENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVREsgsLSPEHGPVVVHCSAGIGRSGTFCLADTCLLlmdkrkdpSS
| . .|.  ...      . .. ..|......|. |||.|||.... .|.||  ..|   . .|.|||.||||||.||.||...|. .||         .
lkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll........lg

VDIKKVLLEMRKFRMGLIQTADQLRFSYLAV
|.. ..| ..|. |.| ... .|||| |...
vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 77-271 2.8e-25 83.6 In-house 3-197 (199) alignment 
Range on Protein: 77-271
Range on HMM: 3-197/199.0
AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQ--ETREILHF
.|| || || || .|   ||.||||  |  .||.|    .     . |||  |     .    | .|  .   |. ||.  | | | ||    |||| |.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygs..lsvttktittkpdytitaliltnnttappstreishy

HYTTWPDFGVPESpASFLNFLFKVRESGSL-S-PEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
 .|.| .   |.  | |. |.   ||           ||.|||| | | .| |   |  .   .. |  | ||. .|   .|. | |.| . ..  | |
qftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 77-271 3.5e-25 83.4 In-house 2-196 (198) alignment 
Range on Protein: 77-271
Range on HMM: 2-196/198.0
AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDtnLKLTLISEDIKSYYTVRQLELENLTTQ--ETREILHF
.|| || || || .|   ||.||||  |  .||.|    .     . |||  |     .    | .|  .   |. ||.  | | | ||    |||| |.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygs..lsvttktittkpdytitaliltnnttappstreishy

HYTTWPDFGVPESpASFLNFLFKVRESGSL-S-PEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
 .|.| .   |.  | |. |.   ||           ||.|||| | | .| |   |  .   .. |  | ||. .|   .|. | |.| . ..  | |
qftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
0048179 (Phosphotyrosine protein) phosphatases II 153-269 1.5e-24 81.8 In-house 31-136 (144) alignment 
Range on Protein: 153-269
Range on HMM: 31-136/144.0
YTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlspEHGPVVVHCSAGIGRSGTFCLADTCLllmdkrkdPSSVDIKKVLLE
.||  |  |   . ..||....... |||.|||.... .|.||  ..|  .   |.|||.||||||.||.||...|. ..           ......| .
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealal

MRKFRMGLIQTADQLRF
.|. |.| ... .||||
vrsrrpgavpnpgqlrf
subfamily_hpo-7_pd Subfamily hpo-7 77-276 1.7e-24 81.2 In-house 36-225 (263) alignment 
Range on Protein: 77-276
Range on HMM: 36-225/263.0
AQRSYILtqgpLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEdiksYYTVRQLELENLT--TQETREILHF
 . .|.|    | .|   |....  .|.  ||||    |.|  || .|.| . .. ..... |.  | . .       .. ||| .     ..|... |.
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhy

HYTTWPDFGVPESPASFLNFLFKVRESGSlspehgpVVVHCSAGIGRSGTFCLADTCLLLMDK---RKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
 |. |..   || . . || |  .|.| |       .|||||.|||||  | .|..    | .     .   .|  ..| |.|. | . |.|  || || 
sykgWiekndpelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

LAVIE
| |..
lmvLd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 58-277 1.2e-23 78.0 In-house 55-287 (302) alignment 
Range on Protein: 58-277
Range on HMM: 55-287/302.0
KLHQEDNDYINASLIKMEEAqrSYILTQGPL-----------------PNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNL
|| . .||.||| ..|..|   ..|..|||.                  .|.  .| .. . .   || |  ..|..  |||.|. .| ..|. |    .
klvdfkndfinanvlkldei..kwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytv

KLTLISEDIKSY-----YTVRQLELENLTTQET--REILHFHYTTWPDFGVPESPASFLNFLfKVRESGSLSpehgpVVVHCSAGIGRSGTFCLADTCLL
|   . .|.. .     ... ..|..|  ...   . .  .....||| | |. . . |. | |  ||   .     |.||||||.||.||.      . 
ktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldil.kfcesykkn.....vlvhcsaGvGrtGtlvaikyGiq

LMDKRKdpsSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
|  |.|     |. ...| .|. | | .|...|| .  | |  |
lcskkk...vtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 63-275 7.6e-23 76.1 In-house 45-256 (290) alignment 
Range on Protein: 63-275
Range on HMM: 45-256/290.0
DNDYINASLIKMEEAQRsYILTQGPLPNT-------CGHFWEMVWEQKSRGVVMLNRVMEKGSL----KCAQYWPQKEEKEMIFEDTNLKLtlISEDIKS
 .||| |. ... . .|  |||| |. ..         .|| |. . |.. ||||  ..|| .      ||.| |.....|. |.. ..|    |   . 
nddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..kskeked

YYTVRQLELEnLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSlspehgPVVVHCSAGIGRSGTFCLADTCLLLM-DKRKdpsSVDIKKVL
   .|.|...    .|   . |  .  | .  |.|.. ..|. . ||. |..      ||.|||  || || ..   .    .. ....   || ...||
dvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsg...svkledvl

LEMRKFRMGLIQTADQLRFSYLAVI
 ..|| |  .|..| .| |   ...
kalrkqralaitsalelafvdagiv
subfamily_egg_pd Subfamily egg 38-269 3.8e-22 73.4 In-house 38-261 (307) alignment 
Range on Protein: 38-269
Range on HMM: 38-261/307.0
PKNKNRNRYRDVSPFDHSRIKLHQE----DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKgsLKCAQYWPQKEEKEM
  |... | . |   | ||.||. .     .|.| |  .| .     .||.| || ||   || ||.... . .|||.   |    .|  |||. |.. .
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

IFEDTNLKLTLISEDIK--SYYTVRQLELenLTTQetREILHFHYTTWpDFGVPESPASFLNFLFKVRESGSlspehgPVVVHCSAGIGRSGTFCLADTC
..   .|... .  | |    ..| .| |  . ..  .| ..  .  . |.       | |. | |.|.         ||||..  |. ...|.  ... 
vtvpGslrienlkvdskadplfrvtklkl..vGgd..deerflehwqg.dvnnssdvysplrvlrklrnlsk......pvvvqdilGvskaatlvaieia

LLLMDKRkDPSSVDIKKVLLEMRKFRMGLIQTADQLRF
|| . .        ...    .|. |   .... .  |
llsllrG.pitkslvlravvflrlrrrlsvesvllylf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 13-131 3.4e-21 70.4 In-house 22-156 (350) alignment 
Range on Protein: 13-131
Range on HMM: 22-156/350.0
SGSWAAIYQDIRHEASDFpcRVAKLPKNKNRNRYRDVSPFDHSRIKLH------------QEDNDYINASLIKME----EA--QRSYILTQGPLPNTCGH
. |  ..  |.  .  |.   ...  .   .|||... |..|||.||.             . ||||||. .|..    |   .  || ||.|||.|   
vksrlsLesdsespsnDv..ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvdd

FWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEK
|.... . | . ...|.  .| .  || .||.. . .
fykvillnkvkvilsltsdvelnlekcyrYWqegsyd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 32-275 7e-21 68.9 In-house 45-282 (302) alignment 
Range on Protein: 32-275
Range on HMM: 45-282/302.0
CRVAKlpKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTC---GHFWEMVWEQKSRGVVMLNRVMEKGSlKCAQYWPQK
|.. |  || ..|.  ||   |. ..||..| ..|.||| ... | .|| ||.| |  ..     .|| ||...|   ||.| .  |       ...|.|
Ckafk..knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

EEKEMIFEDTNLKLTLISEDIKSYytvRQLELENLTTQETREILH--FHYTTWPDFGVPESPASFLNFLFKVreSGSLSPEHGPVVVHCSAGIGRSGTFC
 ..   ...  .    ...  ..     .. .| |    .  .|    . | |..  ||.. |.  .   ||    . ..   ..|.    |.|| |.| 
sgdykeygkmfvNnrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafl

LADTCLLLMDKRKDPSsvdIKKVLLEMRKFRMGLIQTADQLRFSYLAVI
 . . .  ..| |.|    || ..  .|. |   .....|  . |.|..
tlavaveklqkgkepn...ikeivksiRsqRpravdslkQyvslyiall
subfamily_eak_pd Subfamily eak 33-203 3.6e-20 66.6 In-house 45-212 (332) alignment 
Range on Protein: 33-203
Range on HMM: 45-212/332.0
RVAKLPKNKNRNrYRDVSPFDHSRIKLHQ---EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKE
....  .. |||   .. |.|.  ..|     . . ||||||... |  | ||||  .  .    ||.|| ||||  .|.|   .|..  |  .|.|.| 
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

EKEMIFEDTNLKltLISEDIKSYYTVRQLELEnlTTQETREILHFHYTTWPDFGVPESpASFLNFLFKVRESGS
 .|. |   ...    .   .. . .|.|||.     || ..||...  | .. .|     || .   ..| | 
reelkfGildve..rkefvkrniletrllels..kGnethrvlhykvfGwtettlpky.edflalrkvmkevGv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 154-289 1.6e-17 58.0 In-house 74-203 (440) alignment 
Range on Protein: 154-289
Range on HMM: 74-203/440.0
TVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSpEHGPVVVHCSAGIGRSGTFCLADTcLLLMDKRKDpsSVDIKKVLLEM
    ..   ..  |.| . ..||  ||| |||.  .  |...  | ||   .   ||..|||||| ||.|     |. .|   || |   .||  ..  |
dsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavds.ilreakrsd..qidifsfinsm

RKFRMGLIQTADQLRFSYLAVIEGakFIMGDSSVQD
|. |  ..|| .|  | . ||.||  .. ||. . .
rnnrpqmvqtpeqyafvheavleg..llcgdtlile
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 35-183 3.1e-16 53.7 In-house 91-234 (244) alignment 
Range on Protein: 35-183
Range on HMM: 91-234/244.0
AKLPKNKNRNRYRDVSPFDHSRIKLHQE--DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKgslkcAQYWPQKEEKE
|  |.|  .||     ||| .|. | .    | |||||..        ||||| || .|   || |. |..   .|.|  | |.      .|||. |  |
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseple

MIFEDTNLKLTliSEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFG
   ||  . ||    |        .||.|    .  . .  |  . ||  |
wyeeditvtlt..drdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 149-274 2.7e-13 44.4 In-house 198-340 (350) alignment 
Range on Protein: 149-274
Range on HMM: 198-340/350.0
IKSYYTVRQLElenLTTQETREILHFHYTTWPDFGVPESPASFLNFLF--------KVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLL---LMD-
.| .... ...   |.. .  .......  |.| ..   | |.|. |          . || . . .  |..||||||.|| ||..  |  |     .. 
lkdnnsltait...laasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilen

--K----RKDPSS--VDIKKVLLEMRKFRMGLIQTADQLRFSYLAV
  |     . ..     |. ...|.|| |. ..|. ||  | | |.
ltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 51-183 7e-13 43.0 In-house 4-125 (130) alignment 
Range on Protein: 51-183
Range on HMM: 4-125/130.0
PFDHSRIKlhqeDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKgslkcAQYWPQKEEKEMIfeDTNLKLTLISEDIK
.|. ||..    .|.|||||.. . .  . |.||| || .|. .|| |. |.    .|.|  | |.      .|||. |  |    .... .||   |  
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewy..eediivtltdrdef

SYYTVRQLELENLTTQETREILHFHYTTWPDFG
 .    .|| |.   .  . .  |. . ||  |
knikasnleiesdlneshqaltmfqisnwpsdg
subfamily_CG42327_pd Subfamily CG42327 207-281 1.7e-12 41.7 In-house 246-318 (319) alignment 
Range on Protein: 207-281
Range on HMM: 246-318/319.0
EHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKdpSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFI
..||.||||| |.||.|.   .|  .  ... |   |||| ...  .|. |   ..| .|  | |  . | ||..
sqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 34-110 5.7e-12 39.8 In-house 31-116 (347) alignment 
Range on Protein: 34-110
Range on HMM: 31-116/347.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQE---------DNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML
...  |. ..|| .||   | .|. |  |          . ||||| ||...|.. ||||| |||.|   || ||   |   || .
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
PTEN_1 165-269 5e-10 34.5 In-house 88-184 (196) alignment 
Range on Protein: 165-269
Range on HMM: 88-184/196.0
TQETREILHFHYTTWPDFGVPeSPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLAdtclLLMDKRKdpssVDIKKVLLEMRKFR-MGLIQT
... .. . ..   ..|.|.| | .... .. .. |. .. |... |.||| ||.||||| . |    .|| |.|     . .. |  .|. |  | ...
eeffksgveylhfpieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk....ltadeAlelvrekRppgapns

ADQLRF
. | |.
psqerl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 63-130 8.9e-10 32.4 In-house 89-158 (349) alignment 
Range on Protein: 63-130
Range on HMM: 89-158/349.0
DNDYINASLIKMEE--AQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEE
 .|||||  .|. .  ... || || ||| |   |....  .. . |. ||   |..  || .|| . . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 23-118 2.4e-09 31.1 In-house 17-115 (332) alignment 
Range on Protein: 23-118
Range on HMM: 17-115/332.0
IRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQED--NDYINASLIKMEEAQRSYILTQGPLPNT-CGHFWEMVWEQKSRGVVMLNRVMEKGS
..  |  .|    |. .| . ||   .  |||||..|  .|  .|. ||| .     . .||..| |. .     || || |.|   ....  . ||  
mhtsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
0038934 (Phosphotyrosine protein) phosphatases II 172-270 7.2e-09 31.1 In-house 80-169 (194) alignment 
Range on Protein: 172-270
Range on HMM: 80-169/194.0
LHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEhGPVVVHCSAGIGRSGTFCladtCLLLMDKRKdpssVDIKKVLLEMRKFRMGLIQTADQLRFS
....   .||.|.. | .  |.||  | |  . .|. | |.||| ||.||.||..    .  |. ...     . .. .  .|  | | |.. |.|.  
ieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlv....aaYLiyrlg....msaeeAialfrekRpgaipnqdyleal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 30-75 7.5e-08 26.1 In-house 37-86 (440) alignment 
Range on Protein: 30-75
Range on HMM: 37-86/440.0
FPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINASLIKME
 |. .| ||.|| .||||..  .||||. |..     |.|||||| |.  
qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 163-249 7.8e-08 26.0 In-house 212-307 (349) alignment 
Range on Protein: 163-249
Range on HMM: 212-307/349.0
LTTQETREILHFHYTTWPDFGVPESPASFLNFLFkVRE---------SGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLM-DKRKDPSSVDIKKV
|....  |.| . .  |.| ..   | |.|. |  |..             . .  ...|||||| ||.|...  |  | ..   ...   .... .
lavekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqal
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 34-191 1.8e-07 24.2 In-house 21-161 (169) alignment 
Range on Protein: 34-191
Range on HMM: 21-161/169.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINAslikmeeaqrsyiltqgplpntcghfwEMVWEQKSRGVVMLNRVMEKgslkcAQYWPQKE
.|.|  |. .||        | |.||..      .|||||                           .|.||  .  .|.|    .|      ..||.||
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpeke

EKEM----IFEDTN--------LKLTLISEDIKSYYTVRqLELENLTTQETREILHFHYTTWPDFGVPESPASF
. ..    |. .           |..  .. ... . |  . . .   . | ..  .||.|||. |||.||   
dyqlhpavilgewytdslyvrtdkvhantsgveglfevs.mvihsydddvteklsllhystwpqngvpqspvhv
subfamily_PTPDC1_pd Subfamily PTPDC1 169-269 2.4e-07 25.4 In-house 81-167 (182) alignment 
Range on Protein: 169-269
Range on HMM: 81-167/182.0
REILhFHYTTWPDFGVPeSPASFLNfLFKVRESgslSPEHGPVVVHCSAGIGRSGTFCladTCLLLMDKRKDPSsvdikKVLLEMRKFRMGLIQTADQLR
..|  ..  .|.|.||. |  . |. . || ..   . ..| | ||| || || |      .| |.  || ...     | .  .|. |   ||| .|..
qgiy.vynfgwkDygva.sleriLd.ivkvvaf...alqegkvavhChaGlGrtGvli...acylvyakrltae.....kaiklvrskrpksiqtreqve

F
.
l
PTPc_motif_SM00404 205-228 4.3e-07 24.9 In-house 77-100 (140) alignment 
Range on Protein: 205-228
Range on HMM: 77-100/140.0
SPEHGPVVVHCSAGIGRSGTFCLA
  ..| |.||| ||. ||.|...|
ekkggkvlVHCqaGvSRSatliia
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 34-191 4.5e-07 22.9 In-house 20-160 (169) alignment 
Range on Protein: 34-191
Range on HMM: 20-160/169.0
VAKLPKNKNRNRYRDVSPFDHSRIKLHQ----EDNDYINAslikmeeaqrsyiltqgplpntcghfwEMVWEQKSRGVVMLNRVMEKgslkcAQYWPQKE
.|.|  |. .||        | |.||..      .|||||                           .|.||  .  .|.|    .|      ..||.||
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpeke

EKEM----IFED-TNLKLTLISEDIK-------SYYTVrQLELENLTTQETREILHFHYTTWPDFGVPESPASF
. ..    |. .     | . .. ..       . . | .| ...   . |...  .||.|||. |||.||   
dyqlhpavilGewytdslyvrtdkvhpntsgveglfev.slvihsydddvteqlsllhystwpqngvpqspvhv
DSPc Dual specificity phosphatase, catalytic domain 206-228 2.6e-06 22.3 Pfam-A 71-93 (133) alignment 
Range on Protein: 206-228
Range on HMM: 71-93/133.0
PEHGPVVVHCSAGIGRSGTFCLA
 ... |.||| ||| ||.|...|
qkgkkvlVHCqaGisRSatliia
DSPc Dual specificity phosphatase, catalytic domain 206-228 2.6e-06 22.3 In-house 71-93 (133) alignment 
Range on Protein: 206-228
Range on HMM: 71-93/133.0
PEHGPVVVHCSAGIGRSGTFCLA
 ... |.||| ||| ||.|...|
qkgkkvlVHCqaGisRSatliia
subfamily_CDKN3_pd Subfamily CDKN3 162-269 5.7e-06 20.0 In-house 90-187 (202) alignment 
Range on Protein: 162-269
Range on HMM: 90-187/202.0
NLTTQETREILHFHYTTWPDFGVPeSPASFLNFLFKVRESgsLSPEHGpVVVHCSAGIGRSgtfCLADTCLLLMDKrkDpsSVDIKKVLLEMRKFR-MGL
.|  . ..  |  |.   .| .|| ..|| |..| ..| .  |   ..  .|||  |.|||   .|  .||||. .  |   .. |. . ..|...  . 
rlldlyqqaglivhhypiadglvp.diasclkileelrin..lkayrk.tlvhcygglgrs...slviaclllyld..d..tiepkdaidklrdlkgsra

IQTADQLRF
|||  |  .
iqtvkqyny
0048567 (Phosphotyrosine protein) phosphatases II 171-226 6e-06 20.7 In-house 30-95 (157) alignment 
Range on Protein: 171-226
Range on HMM: 30-95/157.0
ILHF-------HYTTWPDFGvPESPASFLNFLFKVRESGS-LSPEHGPVVVHCSAGI---GRSGTFC
 |.|       ... . ||| | . | . .|  |. .  . |. ......|||.||    ||..|..
alyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 212-277 7.5e-06 20.3 In-house 2-64 (69) alignment 
Range on Protein: 212-277
Range on HMM: 2-64/69.0
VVHCSAGIGRSGTFCladTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
|||||.| ||.|||    . .. | . |    |||   .  ||| |  ..    .  | . |..| 
vvhcssgtgrtgtfi...aimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea