Gene PTPN2 in Homo sapiens

Synonym: PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, PTPN2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP071_AA protein Get Run
HsapP071_AA_6-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN1_pd Subfamily PTPN1 12-318 3.3e-162 533.1 In-house 2-290 (290) alignment 
Range on Protein: 12-318
Range on HMM: 2-290/290.0
LDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVM
||..|.....||.||.|..|.|.|.||.|||||.|||||||||||||.||..|.|||||||||..|||.|||||||||||||..|||.|||.||.|||||
ldkkrlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LNRIVEKESVKCAQYWPTDDQ--EMLFKETGFSVKLLSEDVKSYYTVHLLQLENinyienlwitlylkllmldvkrsLKSGETRTISHFHYTTWPDFGVP
||..||||..|||||||....  |.|...| ..|||.||..||||||.||.|||                       ||. |||.|.|||||||||||||
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen.......................lktqetreilhfhyttwpdfgvp

ESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDS
||||.||.|||||||||||..|.|||||||||||||||||.||||||||.|| ||   ..||.|||..||||.|||||.|||||||.||.||||.|||||
espaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgds

SIQKRWKELSKE
|.||||||||||
svqkrwkelske
0036941 (Phosphotyrosine protein) phosphatases II 9-314 5.2e-97 320.0 In-house 6-292 (297) alignment 
Range on Protein: 9-314
Range on HMM: 6-292/297.0
FEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKA
.|.|.   ...  . |. .  .... .||..|||...|||.|. ||||.||||.. ..||||||.||. . .| .|.||||||||. .|| |||.|... 
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVMLNRIVEKESVKCAQYWPTD-DQEMLFkeTGFSVKLLSEDV--KSYYTVHLLQLENINYienlwitlylkllmldvkrslksGETRTISHFHYTTWPD
.|||.. ||.. .|||||||.. .... .   .|.|.|||..|  ...||.. |.......                       ||.||. |||||.|||
Ivmltelvelgrekcaqywpleegeslty..gdftvtllsvevvllddytlrtlevtdtgn.......................gesrtvthfhytgwpd

FGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLME---KGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCI
.||||||||.|.|. .||.  .| |..|| ..|||||.|||||| ..|..| ..|   |   ..|..... .|..|.| .||..|.|| |.|..|  |..
hgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

KGDSSIQKRWKE
. . ...| ...
ltkepllklvll
0050432 (Phosphotyrosine protein) phosphatases II 7-303 2.3e-95 314.8 In-house 33-303 (308) alignment 
Range on Protein: 7-303
Range on HMM: 33-303/308.0
REFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLqNAENDYINASLVDIE--EAQRSYILTQGPLPNTCCHFWLMVWQQ
. .|...   ...  . |...   ... .||..|||...|||.|. ||||||||| . ..||||||.||.     .| .|.||||||||. .|| |||.|
kllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

KTKAVVMLNRIVEKESVKCAQYWPTD--DQEMLFKetGFSVKLLSEDVKSYYTVHLLQLENINyienlwitlylkllmldvkrslkSGETRTISHFHYTT
... .|||...||.. .|||||||..  .. . ..  .|.|.||||.|...|||  |.|.|..                       .||.||. |||||.
nvrvIvmLtklvengrekcaqYwplelgggsleyg..kftvtllseevlddytvrtleltnlg.......................dgesrtvthfhytn

WPDFGVPESPASFLNFLFKVRESGslnpDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCI
|||.|||.||...|.|| .||.|     ..|| |.|||||.||.||| ..|..| ..||.  ... ...  .|..|.| .|||.|..| |.|..| .|..
WpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

K
.
l
0047943 (Phosphotyrosine protein) phosphatases II 9-297 7.8e-95 312.7 In-house 5-270 (273) alignment 
Range on Protein: 9-297
Range on HMM: 5-270/273.0
FEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKA
.|.|.  ....  . ....  .... .||..|||...|||.|. |||||||||.. ..||||||.||  . .| .|.||||||||. .|| |||.|... 
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

VVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINyienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGV
.|||...||.. .|||||||.. .|.  .   |.|.||||..|..|||. |.|.|..                       .||.||. |||||.|||.||
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.......................tgesrtvthfhytgwpdhgv

PESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|.|..|.|.|. .||.  . .|..|| |.|||||.||.||| ..|..| ..||.  .......  .|..|.| .|||.|.|| |.|..|
ppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 13-298 1.5e-92 305.4 In-house 20-285 (288) alignment 
Range on Protein: 13-298
Range on HMM: 20-285/288.0
DTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKA
. . ...  . |...  .|.. ..|..|||...|||.|. |||||||||..     ..||||||..|. . .| .|.||||||||. .|| |||.|... 
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

VVMLNRIVEKESVKCAQYWPTdDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINYIEnlwitlylkllmldvkrslKSGETRTISHFHYTTWPDFGV
.|||...||.. .|||||||. .. . ...  ..|.||||.|...|||. |...|.....                   ..||.||. |||||.|||.||
IvmltklvelgrekcaqYwpl.ggsltygd..itvtllseevlddytvrtlevtnldlld...................gdgesrtvthfhytnwpdhgv

PESPASFLNFLFKVRESGSlnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEG
|.|| ..|.|| .||.. .  ...|| |.|||||.||.||| ..|..| ..||.  ... ...  .|..|.|..|||.|.|| |.|..| 
pdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 16-333 2.8e-92 304.7 In-house 18-310 (317) alignment 
Range on Protein: 16-333
Range on HMM: 18-310/317.0
RRWQPLYLEIRNESHDyPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVM
....  . .... ..| . .||..|||...|||.|. |||||||||.. .    .||||||.||. . .| .|.||||||||. .|| |||.|... .||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LNRIVEKESVKCAQYWPTdDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINYienlwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPES
|.. .|.. .|||||||. .... ...  |.|.||||......|.. |..|. .                        .|.||. |||||.|||.|||.|
LteleelgrekcaqYwpl.getltygd..ftvtllseeelagitlrtlevedlgd.......................sesrtvthfhytgWpdhgvpps

PASFLNFLFKVRESGSlnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKR
| ..|.|| .|||. .  ...|| ..|||||.||.||| .....| ..||. ........  .|..|.| .|||.|.|| |.|..|  |.   . .... 
pdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel

WKELSKEDLSPAFDHSPNKIMT
...| |.   .|.| ...|.. 
klkllklliplalddvklkeke
0046845 (Phosphotyrosine protein) phosphatases II 28-303 1.3e-91 302.1 In-house 12-278 (284) alignment 
Range on Protein: 28-303
Range on HMM: 12-278/284.0
ES--HDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN-----AENDYINASLVDIE-----EAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRI
    . .. .||..|||...|||.|. |||||||||..      ..||||||.||         .. .|.||||||||. .|| |||.|... .|||...
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltel

VEKESVKCAQYWPTDDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINYienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGVPESPASF
||.. .|||||||.... . ...  |.|.||||.||..|||. |.|.|..|                      .||.||. |||||.|||.|||.||...
vengrekcaqYwplegevltygd..ftvtllseevkddytvrtleltnlgy......................tgesrtvthfhytswpdhgvppspedl

LNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD---DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIK
|.|| .|||. . .|..|| |.|||||.||.||| ..|..| ..||..    ... ...  .|..|.| .||..|.|| |.|..| .|...
leflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 15-297 4.2e-86 284.7 In-house 26-302 (307) alignment 
Range on Protein: 15-297
Range on HMM: 26-302/307.0
QRRWQPLYLEIRNESH--DYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN-----AENDYINASLV--------DIEEAQRSYILTQGPLPNTCCHFWL
  ...  . ..... .   .....|..|||...|||.|. ||||.||||..      ..|||||| |        |.   .| .|.||||||.|. .|| 
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

MVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINYIEnlwitlylkllmldvkrslksgETRTISHFH
|.|.|.....|||.. ||....|||||||....|. ...  | |.||||.....|||. | ... .. .                      |.||. |||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygn..ftvtllseehldgytvrtlevtdldgtg......................esrtvthfh

YTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
||.|||.|||.|....|.|. .||.  . .|..|| ..|||||.||.||| . ...|...||.     ... ...  .|. |.| .|.|.|.|| |.|..
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

E
|
e
subfamily_PTPRD_pd Subfamily PTPRD 21-318 3.2e-83 275.3 In-house 28-301 (564) alignment 
Range on Protein: 21-318
Range on HMM: 28-301/564.0
LYLEIRNEsHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEN----DYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIV
 | .|... .  . ..|. |.|...||| .. .||||||.|.. |.    |||||| .|  .....|| |||||..|.  || |||.|... .|||....
eykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

EKESVKCAQYWPTDDQEMLfkeTGFSVKLLSEDVKSYYTVHLLQLENINyienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGVPESPASFL
||. |||..|||....|      .. |.| .|  ...|..  ..|.. .                       | |.|.. .||.| ||| |||||..|.|
EkgkvkchkYWPekgtety...geltVtleeeeeladyeirtfklkkkk.......................ssesreVrqFhFtsWPdhgvpesatslL

NFLFKVRESGslNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELS
... |||..   .||.|| |.|||||.||.|||  .| .|  ... ....| |.. ..|| |  ..||..|  | . || |  .| . . ....  ..|.
dlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

K-E
| .
kLa
0043336 (Phosphotyrosine protein) phosphatases II 15-296 7.4e-83 273.5 In-house 19-274 (278) alignment 
Range on Protein: 15-296
Range on HMM: 19-274/278.0
QRRWQPLYLEIRNESHdYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVV
.....  . |...  . .. ..|..|||...|||.|. |||||||||.. .    .||||||.||  . .| .|.||||||.|. .|| |||..... .|
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MLNRIVEKESVKCAQYWPtdDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENinyienlwitlylkllmldvkrsLKSGETRTISHFHYTTWPDFGVPE
||.. ||...||||||||  .. . ...  |.|.||.|.....|||. | ..|                       |..||.||. |.||. |||.||||
mLtelvelgrvkcaqYwp..ggsltygd..ftvtllkeehlddytvrtlevtn.......................lgdgesrtvthyhylgwpdhgvpe

SPASFLNFLFKVRESGSlnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
|....|.|| .|||  .  ...|| ..|||||.||.||| .....| ..||.  ... ...  .|..|.| .|||.|.|| |.|..
slsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 22-302 2.9e-82 271.8 In-house 38-292 (297) alignment 
Range on Protein: 22-302
Range on HMM: 38-292/297.0
YLEIRNESHDypHRVAKFPENRNRNRYRDVSPYDHSRVKLQN-----AENDYINASLVDIEEA-QRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRI
. |. .  .|   ..|..|||...|||.|. |||||||||.       ..||||||.||  .  .| .|.||||||.|. .|| |||.|.....|||.. 
feellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtkl

VEKESvKCAQYWPTDDQemlfKETGFSVKLLSEDVKSYYTVHLLQLeninyienlwitlylkllmldvkrsLKSGETRTISHFHYTTWPDFGVPESPASF
||..  |||||||.. .    .  .|.|.||.......|||  | .                          ..||.||. ||.|| |||.|||.|....
velgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlev.........................tnngesrtvthfqytgwpdhgvppslell

LNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCI
|.|| .|||  . .|..|| ..|||||.||.||| . ...| ..||. ........  .|..|.| .|||.|.|| |.|..|  |..
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 23-297 2.7e-80 264.8 In-house 16-260 (263) alignment 
Range on Protein: 23-297
Range on HMM: 16-260/263.0
LeirneshdyPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEK
          . . |....|...|||... ||||.||||.. |    .|||||. ..... ...||.||||||.|. .|| |||..|.| .|||.. .|.
k.........etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

ESVKCAQYWPTD-DQEMLFKetGFSVKLLSEDVKS-YYTVHLLQLENINYienlwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPESPASFL
.. ||..||| . .... |.   .|||| ... |.  .... |.|.. .                         |||.. ...|..||| |||.|. |.|
gkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegk.......................eetrkvtqyqyknWpdhgvpdstksvl

NFLFKVRESGSLNpdHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
..| .|..| | .  .|| |.|||||.||.||| ..|..|  .|......|.... ..|| |.|..|| .|..| |.||.|
ellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 23-297 2.7e-80 264.8 In-house 16-260 (263) alignment 
Range on Protein: 23-297
Range on HMM: 16-260/263.0
LeirneshdyPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEK
          . . |....|...|||... ||||.||||.. |    .|||||. ..... ...||.||||||.|. .|| |||..|.| .|||.. .|.
k.........etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

ESVKCAQYWPTD-DQEMLFKetGFSVKLLSEDVKS-YYTVHLLQLENINYienlwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPESPASFL
.. ||..||| . .... |.   .|||| ... |.  .... |.|.. .                         |||.. ...|..||| |||.|. |.|
gkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegk.......................eetrkvtqyqyknWpdhgvpdstksvl

NFLFKVRESGSLNpdHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
..| .|..| | .  .|| |.|||||.||.||| ..|..|  .|......|.... ..|| |.|..|| .|..| |.||.|
ellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0045098 (Phosphotyrosine protein) phosphatases II 19-302 2.3e-78 258.6 In-house 10-275 (278) alignment 
Range on Protein: 19-302
Range on HMM: 10-275/278.0
QPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKlqnaenDYINASLVDIEeaQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEK
.  . ...  .. .   .| ...|...|||.|. ||||||||      ||||||..|.   .. .|.||||||.|. .|| |.|.......|||.. ||.
llefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

ESVKCAQYWPTdDQEMLFkeTGFSVKLLSEDVKSYYTVHLLQLENINYIENLwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPESP--ASFL
. .|||||||  .. . .   .|.|.||||.| ..||.. | ..|... ..                    .|.|.. |.||..|||.|||..|  .|||
grekcaqywpe.ggslty..gdftvtllseevlddytlrtllvtnltvered...................lesrgvthlhylpwpdhgvpslpilksfl

NFLFKVRESGS-----------LNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMekGDDINIKQVLLNMRKYRMG-LIQTPDQLRFSYMAIIEGAKCI
..|  .||  .           |....|| ..|||||.||.||. .....| |.  .. ... ...  .|..|.|  .|...|.|| |....|  ...
ellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0040439 (Phosphotyrosine protein) phosphatases II 33-297 5.4e-78 257.3 In-house 2-244 (249) alignment 
Range on Protein: 33-297
Range on HMM: 2-244/249.0
PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWP
. .||..|||...|||.|. |||||||||.  .    .||||||..|    .| .|.||||||.|. .|| |.|... ...|||.. ||.. .|||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TdDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINyienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL
. .... ...  |.|.|||..||..|||  |.|.|.                         ||.||. |..|| |||.|||.|....|.|. .||.  . 
l.ggsleygd..ftvtllsvevkddytvrtleltnly.......................dgesrtvlhiqytdwpdhgvppsfedlldfieavrkalee

NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
.|..|| ..|||||.||.||| . ...| ..||  ........  .|..|.| .|.|.|.|| |.|..|
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 42-297 1.2e-76 252.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 42-297
Range on HMM: 1-235/235.0
NRNRNRYRDVSPYDHSRVKL--QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEmLFKET
|...|||.|. |||..||||  .. ..|||||. |.  . ....|.|||||..|. .|| ||||.|.|..|||.. .||...|||||||....|   .  
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltyg

GFSVKLL--SEDVKSYYTVHLLQLENINYIEnlwitlylkllmldvkrslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGslNPDHGPAVI
 ..|.|   ... .. ||.. |.|.. .  .                      |.|.....|||.||| |||||| |.|... ||..|   ....|| |.
dikvelkekekedekeytlrklelkkkkees......................ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvV

HCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|||||.||.||| ..|..|  .|........|.. ..|| |.|..|. .|. | |.||.|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 42-297 1.2e-76 252.6 In-house 1-235 (235) alignment 
Range on Protein: 42-297
Range on HMM: 1-235/235.0
NRNRNRYRDVSPYDHSRVKL--QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEmLFKET
|...|||.|. |||..||||  .. ..|||||. |.  . ....|.|||||..|. .|| ||||.|.|..|||.. .||...|||||||....|   .  
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltyg

GFSVKLL--SEDVKSYYTVHLLQLENINYIEnlwitlylkllmldvkrslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGslNPDHGPAVI
 ..|.|   ... .. ||.. |.|.. .  .                      |.|.....|||.||| |||||| |.|... ||..|   ....|| |.
dikvelkekekedekeytlrklelkkkkees......................ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvV

HCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|||||.||.||| ..|..|  .|........|.. ..|| |.|..|. .|. | |.||.|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0042113 (Phosphotyrosine protein) phosphatases II 36-297 4.5e-76 250.8 In-house 3-241 (245) alignment 
Range on Protein: 36-297
Range on HMM: 3-241/245.0
VAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTdD
||..|||...|||.|. ||||.||||.. .    .||||||.||  .  . .|.||||||.|. .|| |.|... ...|||.. .|.. ||||||||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

QEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENINYienlwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLnPD
... ...  |.|.||||.....|||  |...|. .                       .|.|.. |.||. |||.|||......|.||  ||.  .  ..
esltygd..ftvtllseehlddytvrtlevtnlgd.......................desrevihyhylpwpdhgvpdllellldflefvrkalae.ds

HGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
.|| ..|||||.||.||| .....| ..||  .... ...  .|..|.| .|||.|.|| |.|..|
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 35-296 1.1e-72 239.7 In-house 3-239 (243) alignment 
Range on Protein: 35-296
Range on HMM: 3-239/243.0
RVAKFPENRNRNRYRDVSPYDHSRVKLQNaeNDYINASLVDIEEaqrSYILTQGPLPNTCCH----FWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPtd
..|..|||...|||.|. |||||||||..  .|||||.|... .    .|.||||||.|...    || |.|.......|||.. ||.. .|||||||  
siallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

dQEMlfKETGFSVKLLSEDVKSYYTVHLLQLEninyienlwitlylkllmldvkrSLK-SGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL-
 .|.     .|.|.|||| ....|||. |.||                        |. ...||.. |.||. |||.|||.||...|.|| .|||  .  
.gev..tygdftvtllseehlddytvrtllle.......................nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieel

-----NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMekgdDINIKQVLLNMRKYRMG-LIQTPDQLRFSYMAII
     ....|| ..|||||.||.||. . ...| |.    .... ...  .|. |.|  .|||.|.|| |.|..
lsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 13-295 6e-72 237.1 In-house 22-281 (293) alignment 
Range on Protein: 13-295
Range on HMM: 22-281/293.0
DTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKA
|.. |..  | |...  .|  . .|. ..||..|||... |||||||||    .....|||||. ..  ...| .| ||||||.|  .|| |||..|...
dsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

VVMLNRIVEKESVKCAQYWPTDdqemlfketgfsvkllsEDVKSYYTVH---------------LLQLENinyienlwitlylkllmldvkrslkSGETR
.||| ..|||  ||| .|||.|                 |.   |  ..                |..|.                         . |.|
ivmltqlvekgkvkCeeYWPad.................eepvlyGdikvtlvaeeeledwvirelkiek.........................ekeer

TISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYM
.. ..|.|.|||.||||.....|.|. .|||. . . ...| |.|||||.||.|||  .|. |  .|. | ..|  .. ..|. |. |.|| .|  | . 
kvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihq

AI
..
cv
subfamily_PTPN6_pd Subfamily PTPN6 23-296 9e-67 220.2 In-house 35-294 (306) alignment 
Range on Protein: 23-296
Range on HMM: 35-294/306.0
LEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL---QNAENDYINASLVD--IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVE
|. ..... . .. .. |||...|||. . |.||.||.|   . ...|||||. ..  ... ..||| ||| |..|   || ||||.... .||. . ||
lqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevE

KESVKCAQYWPTDDQEMLfkETGFSVKLLSEDVKSYYTVHLLQLENInyienlwitlylkllmldvkrsLKSGETRTISHFHYTTWPDFGVPESPASFLN
.   |||.|||.  ..        ||. .||. ...|..  |.....                       |..|.|.. ..|...||| |||..|  .|.
rgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskk......................kkkkeerevfqyhfksWPdhgvpkdpgavLd

FLFKVRESGSLN--PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG---DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
|| .|..  .     ..|| |.|||||||| ||| ..|. | |.||     ||.|...   .|..| ||.|| .| .| |.|| 
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 11-297 2e-66 219.0 In-house 8-274 (281) alignment 
Range on Protein: 11-297
Range on HMM: 8-274/281.0
ELDTQ--RRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQ
.|...  . ..  | ....   | . . .| .||...|||.... ||..|||.    .| ..|||||. |.  . .. || ||||.|... .|| |||.|
qlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

KTKAVVMLNRIVEKESVKCAQYWPtDDQEmlfketgfsvkllsedvksyyT-------V-HLLQLENINYIEnlwitlylKLLMLdvkrSLKSGETRTIS
| .|.||. | .|.. .|| .||| ||..                     .       | .. . |. .|||        . ..|    . .|||||...
kvsaivmvtreieagklkChrYWP.ddns.....................elkygdvtvkstaeeekatyie........rkfkl....eresgetreve

HFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDhGPAVIHCSAGIGRSGTFSLVDTCLVLM-EKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI
...||.||| |||.... .|.|  .|..  . . .  | |||||||.||.||.  .|. .  . ..  ....|.|. ..|| |. ..||  | .| | |.
qlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav

IE
..
ld
subfamily_PTPRG_pd Subfamily PTPRG 23-298 4.1e-65 215.1 In-house 28-286 (563) alignment 
Range on Protein: 23-298
Range on HMM: 28-286/563.0
LEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEN-----DYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVE
|. .  |.| .   .. |||...||| .. .||.|||||..  .     |||||. .|  . .. .| |||||..|.  || |.|.|... .||.  .||
lqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlve

KESVKCAQYWPTDDQEMLfkeTGFSVKLLSEDVKSYYTVHllqleninyienlwiTLYLKLLMldVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLN
..  || .|||.|. | .     ..|.| .|.|...|||.               || .| |   .|.  .  . ... ..|||.||| ||||...  |.
rgrrkcdvYWPkdesety...galqvtlieeevlalytvr...............tlviknlk..lkkkkqcdteklvrqyhytkWPdhgvPehslpvLi

FLFKVreSGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEG
|  |   | . . . || |.|||||.||.||.  .|| |  ... . .|. ..|  .|  |  |.|| .|  | . |..| 
fvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 34-296 4.8e-64 211.2 In-house 39-276 (288) alignment 
Range on Protein: 34-296
Range on HMM: 39-276/288.0
HRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT
. ... ..| ..||||.. |||. ||||..    |..|||||| .| |. .. || |||||..|  .|| .|...||. .|||. .||..  || .|||.
vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

DDQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLEninyienlwitlylkllmldvkrslKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLN
.|.. .. .  . |.|...  .  .... | ||                         |... ..| ...|..||| ||||| | .|..| .|  . . .
adkpknyGs..vtvtlveskeledfvlrkllle.........................kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

pdHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
   || ..|||||.||.|||  .|. .  .|. | |..  .. ..|| |. |.||  |  | | ...
..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRK_pd Subfamily PTPRK 34-308 3.3e-63 208.4 In-house 35-284 (314) alignment 
Range on Protein: 34-308
Range on HMM: 35-284/314.0
HRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEND----YINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT
  .||  |||..||. |. .||.|||.|.  ..|    ||||.|.|  .  . .| |||||..|   || .|..... ..|||. .||.  ||| .||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

DDQEmlFKEtgFSVKLLSEDVKSYYTVHLLQLENinyienlwitlylkllmldvkRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGslN
| .   ...  . |.|.. .... . | ....|.                      . .  |.|.. .|....|||..|| |  ..|... .| .|   .
dtev..ygd..ikvelvetellaelvvrifrvek.....................largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq..e

PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGakCIKGDSSI
...|. |.||||| ||.|||  .|. | ..|. . ... ..  ..|.... ...| .| .| | .|.|   |. |...|
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea..clcgetai
subfamily_PTPN23_pd Subfamily PTPN23 15-300 1.9e-62 205.7 In-house 18-281 (288) alignment 
Range on Protein: 15-300
Range on HMM: 18-281/288.0
QRRWQPLYLEIRNESHDYPHRVAKFpeNRNRNRYRDVSPYDHSRVKLQNAENDYINASLV-DIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLN
..... |  .  .|...    .||   . ..||.||. ||||.||||.. ..|||||| | |.     ..| ||.||..|   |||||..||.. .||| 
dkkfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmll

RIVEKESVKCAQYWPTD-DQEMLFKEtgfsvkllsedvksyYTVHLLQLENINYienlWITLYLKLLMLDVKrslksgETRTISHFHYTTWPDFGVPESP
   |..  |...|||.| .. . |..               ..| | . .. ..    ..   ||| .||..      .....|| ..|.||..|||.||
skeelgkpkvdrYwPedkgetvkfgd...............lsvtlksvretet....hvervlkletldad......avksvshlqltsWpelGvPasP

ASFLNFLFKVRE--SGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDI-NIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK
 ..|.|| .|..  .   .. . | |.|||||.||.|.|.|| . .  .|||. . .| ||.  .|. |   .|. .||.||| |..| |.
etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Ptp69D_pd Subfamily Ptp69D 24-309 1.2e-58 193.7 In-house 30-296 (307) alignment 
Range on Protein: 24-309
Range on HMM: 30-296/307.0
EIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
.. ..  |   .|..  ||  .||| |. ..|. ||||..    .. |||||| .   . ....|  |.|. .|   || |...|. . .|||  . ||.
kLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn

SVKCAQYWPTDdQEMLFKetGFSVKLLSEDVKSYYTVHLLQLENINYIE-NLwitlylkllmldvkrslksGETRTISHFHYTTWPDFGVPESPASFLNF
  |||.||| . .|. .      ||| ||. .|.|.   |.. ...    ..                    ..| .  .|||.|.|. |||.. . |..
rkkcakYWpie.devqyg..dilvklvseekhsdyiiReldvskkkeesgev...................edsrkvvqyhytgWkDskvPevargllkl

LFKVRESGSLNpdHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQ
. .|||  .||  ..| |.||||| ||||.|  .|  |  ... | ..| ..  ..|. |  |.|  .|  | | |...  .  . | ...
ieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 31-305 3.1e-58 192.3 In-house 35-289 (305) alignment 
Range on Protein: 31-305
Range on HMM: 35-289/305.0
DYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQY
. .  | |  .|...||.... ..|..|..|.. |    .|||||| ||  . . .||..||||.||   || .... |.. .||| ..|| .  || ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

WPTDDQEML-FkeTGFSVKLLSEDVKSYYTVHLLQLENINYienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRES
||.  .|   |    |||.| ||   | |.   |.. . .                       . |.||..... |.||| |||....|.|... .|...
Wpesktekkef..gefsvelksektasdyieRklkisiede......................dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd

gsLNPDHG-PAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGD
   . |.| | ..|||||.||.|.|  ||  |  ..| . ... .|| ..|. ||...|| ||  | . |. |  .| . .
..qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts
subfamily_PTPN14_pd Subfamily PTPN14 22-297 8.3e-58 190.7 In-house 29-294 (300) alignment 
Range on Protein: 22-297
Range on HMM: 29-294/300.0
YLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ---NAENDYINASLVDI--EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIV
| .| ....|    .|| ||| ..||..|| ||...||.|.   .....||||| . .    ..|||| .||||..|.. || |||.|... .||| .. 
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

EKESVKCAQYWPTDDQEMlfKETGFSvkllsedvkSyYTVHllqlENINYIENLWITLYLKLlmldvkRSLKSGETRTISHFHYTTWPDFGVPESPASFL
|.   |. .|.| ....   |.  |            . |     .. .   .  ||  |||      . | |.| ||. |. || ||| |||| . .||
edgkeksfkyfPkleskk..ktvefg.........k.fkvt....tkfsedsdsvittglkl......khlpskeertvwhlqytDWpdhgvPeDvkgfl

NFLFKVR----ESGSLN---PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
..| .|.    .. | .     . | ..|||||.||.|   |.|  .  .|....|.||.||  .|. || |.||  | .| | ..|.
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 36-302 1.7e-57 189.6 In-house 22-271 (274) alignment 
Range on Protein: 36-302
Range on HMM: 22-271/274.0
VAKFPENRNRNRYRDVSPYDHSRVKLQ--NA---ENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT
  . . . ..|||... | ..||| |.  ..   . .||||  .   .| .. |. ||||||||   ||.|..|.... .||| .. |..  |||.|.|.
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

DD-QEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINYIENlwitlylkllmldvkrslksgetrtISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL
.   |.  . .....|  .   .  |.|. | |.. .   .                         . |. || |||  .|... ..|... .|.|| . 
aedyeiserygdveikvekiverndysvrklvlkylerers.........................vkhywytdWPdhksPddantlldlvleveesree

NPDH-GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCI
.  . .|.|.|||||||| | |  .. ..  ...   ... ..  |.|  | |..|| .| .. . |... .|..
enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 25-310 3.4e-57 188.9 In-house 32-294 (319) alignment 
Range on Protein: 25-310
Range on HMM: 32-294/319.0
IRNESHDyPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
... . |   . |. .||...|||... .||..||.|..     . |||||| .|  . .. .| ||.|| ||   || |||....  ||||...|||  
lkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

VKCAQYWPTDDQEmlfKETGFSVKLLSEDVKSYYTVHLLQLENINyieNlwitlylkllmlDVkrslksgETRTISHFHYTTWPDFGVPESPASFLNFLF
||. .|||. . |   .   . |.|..|. .. | .  |.|.. .   .            .|       |||...||.|| ||| .|||.  | |..| 
vklkkywpeenfe...eyGrlivtleeeeeledyiirklklnkks...s............ev.......etRevkhfqyteWpdhdvPekatslldllk

KVRESGSlNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQK
..|.| . ....|| |.|||||.|| |||  .|  |  ...   ... ..  ..|  |  ..|.|.| .| | |..| ... . .  .|.
rirksre.ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqd
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 33-299 4.5e-57 188.1 In-house 11-264 (270) alignment 
Range on Protein: 33-299
Range on HMM: 11-264/270.0
PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEND----YINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW
.. . ..  ... |||.|. |  ..||.|.. |.|    ||||  |  .......|| ..||||.|  .|| |.|..|..|.||.  ..||   ||..||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PTddqemlfketgfsvkllseDVKSYYTVHLLQLENIN---YIENLWITLylkllMLDVKrslKSGETRTISHFHYTTWPDFGVPESPA------SFLNF
|.                   ..|.  ...  ... ..     |. .|.       | ..   ..||.| . ||.|.|||| |||...       . |. 
pa...................epkekvkledgkikvlalseekeegyilt.....rlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkm

LFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGA
| .||.| .   . .| ..|||||.||.||. ..|... |.|.   ... ... ..||.|| |.|.|.| .| | |..| |
lravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPRA_pd Subfamily PTPRA 36-308 3e-55 182.4 In-house 52-302 (330) alignment 
Range on Protein: 36-308
Range on HMM: 52-302/330.0
VAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD
.|.  ||...||. .. |||.||| |..     | |||||| .|  . . ..| .|||. .|   || |.|.||. ..|||  . |..  |||||||.. 
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

QeMLFKEtgFSVKLLSEDVKSYYTVHllqleninyienlwitlylKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPD
  . . .    |..  | |   |||                    |.|. ..  . .  ..| .. ||.|.|||.|||  |   |..| ||..    . .
l.vtyGn..irvevedetvlvdytvr...................kflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

hgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGakCIKGDSSI
  | |.|||||.||.|||  .|. |  ..    ... ... ..|. |  ..||  |  | | .. |    . ||. .
..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley..ylygdtel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 32-312 8e-55 181.0 In-house 39-290 (315) alignment 
Range on Protein: 32-312
Range on HMM: 39-290/315.0
YPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW
.| .|||  ||...||| .. .||.|||.|    .. . ||.||...|  . .| || .|||....   || .|....   .|||. .||.|  |. .||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PtdDQEMLFKEtgFSVKLLSEDVKSYYTVHLLqleninyienlwitlylkllmldvkrSL-KSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG
|  |..... .  ..| . ||.|.. |||  |                          |     . |..  .|||.||| |||..  ...|.  .|.   
p..dkkviyGk..itvtrkseevnteytvrtl..........................svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh

SLNPdhGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCikGDSSIQKRW
  .   |. |.|||||.||.|||  .|. |  .|  . |.. ... ..|. |....|. .| .| | |..|   |  ||.|| .. 
tnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvc..gdtsiaqdl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 16-301 1.6e-54 179.8 In-house 20-285 (290) alignment 
Range on Protein: 16-301
Range on HMM: 20-285/290.0
RRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQ------NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAV
....  .  . . ....   |.  ..|...||.... .||  |. |.      . .|.||||. ..  . ...||.||||..||  .|| ..||.|. ..
egfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtii

VMLNRIVEKESVKCAQYWPTDDQEMlFKEtgFSVKLlsedvksyytvhllqleninyIENLWITLYLKlLMLDVKRSLKSGETRTISHFHYTTWPDFG-V
|||  |.|...||| ||||. |... . |  ||.||                     ...  .. | .   |.|| . ..|..... ... |.|.. | |
vmltniieegkvkCqqYWpdsdtka.yge..fsikl.....................lneetlneyie.rklevknknsagakqsvtqyqitnwdstgkv

PESPASFLNFlfKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKC
..  .. | .  . ..     .  .. |.|||...|||..|  ..| .  ...   |.. ||| ..|  ..|..|| .|... .  ...  ..
tnpqtillvi..eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0041856 (Phosphotyrosine protein) phosphatases II 42-305 5.3e-51 168.1 In-house 1-177 (182) alignment 
Range on Protein: 42-305
Range on HMM: 1-177/182.0
NRNRNRYRDVSPYDHSRvklqnaENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNrivekesvkCAQYWPtddqemlfketgf
|...|||.|. ||||||       .|||||.|..    .. .|.|||||..|. .|. |..... ...|.|.         . .|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

svkllsedvksyytvhllqleninyienlwitlylkllmldvkrslkSGETRTISHFHYTTWPDFGVPEsPASFLNFLFKVREsgslnpDHGPAVIHCSA
                                               . ..|.. ...|. |||.|||. . ..|.|. .|.|      ..|| ..||||
...............................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsa

GIGRSGTFSLVDtclvLMEKGdDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGD
|.||.||. . .    ||.|  .... ...  .|..|.| ..||.|..| ..|. |  .. | .
GvgRtgtlvaay....lmkkl.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 36-304 2.9e-50 166.4 In-house 55-296 (319) alignment 
Range on Protein: 36-304
Range on HMM: 55-296/319.0
VAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNrivekeSVKCAQYWPTDD
 |  ..|...||. .. ..|...|||.. .     |||||| |.    .  || .||||.||   || |.|.... ..|.|         ||.|||| . 
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

QEmlfKETGFSVKLLSEDVKSYytvhllqleninyienlwitlyLKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPD
..   ||  | ||. | .  .                         .  ... .  |  . | |  ||.  ||| |||..|. .. .. |||   | . .
vi...keerfkvkvdsveetae......................yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

HGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKG
. . |.|||||.||.|..  .|. |  |.. . ... ... ..|. |  |.|   |  | |.|..|     . 
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 36-305 7.6e-50 165.0 In-house 19-261 (284) alignment 
Range on Protein: 36-305
Range on HMM: 19-261/284.0
VAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNrivekeSVKCAQYWPTDD
 |  ..|...||. .. ..|...|||..       |||||| .     .  || |||||.||   || |.|.... ..|.|         ||.|||| . 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

QEmlfKETGFSVKLLSEDV--KsyytvhllqleninyienlwitlyLKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLN
..   ||  | ||. | .   .                          .  ... .  |  . |.|  ||.  ||| |||..|. .. .. |||   | .
vi...keerfkvkvdsveesee........................yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske

PDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGD
 .. . |.|||||.||.|..  .|. |  |.. . ... ... ..|. |  |.|   |  | |.|..|     . |
nhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 41-297 4.5e-48 158.5 In-house 2-237 (237) alignment 
Range on Protein: 41-297
Range on HMM: 2-237/237.0
ENRNRNRYRDVSPYDHSRVKLQNA--ENDYINASLV-DIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFK
||. .||| ..  |||||| |. |  . |||||. . ... . ..|| .|||| ..|  || ||||.|   .|||  ..|.. .|| .|||  ||   . 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EtgFSVKLLSEDVKSYYTVHLLQLENINYIEnlwitlylkllmldvkrslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVI
   ..| |  ..  | |||  | | .   ..                      | | |  ...|.||| |||.  |..| |  .. .     .. || .|
v..ltvslkkkeefsdytvrslllskrltlk......................evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwii

HCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|||||.||.| | ..|. |   ..   ..| . . .. . |  .||| ||  | . .|.|
hcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 31-305 8.1e-48 157.7 In-house 22-270 (283) alignment 
Range on Protein: 31-305
Range on HMM: 22-270/283.0
DYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDI---EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW
| .  .|   ||.. ||.... |.|  ||.|..  .|||||. . .   .. .. || .|.|| .|   || ||...|  |.||| .. | . .||.|||
dldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PTDDQEMlFKEtgFSVKLLSEDVKSYYTVHLLQLENInyienlwitlylkllmldvkRSLKSgeTRTISHFHYTTWpdfgVPESPASFLNFL--FKVRES
| .  |  . |  | | |  |  .  .....| | .                      | ||  |  ..|. .  |    .  .. . .| |  |    |
PkrGsed.yGe..ftvtlrkettsnsfiikelllrvn....................ssaks..tlllahyqvidW....leygeqaiinslvkfnkvis

GSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCikGD
   .  .|| |.|||.||||...|  . . .  .     ... .|. .||. ||...|| || .. . ...| | |  ||
lqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc..gd
subfamily_CG7180_pd Subfamily CG7180 40-296 1.4e-46 153.5 In-house 40-287 (296) alignment 
Range on Protein: 40-296
Range on HMM: 40-287/296.0
PENRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESvKCAQYWPTDDqEML
 |||..||. .| |||. || |.    ....|||||. ||    .. || |..|  .|   || .|......|||.| .  . .  .. .||| .  .  
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keq

FKEtgFSVKLLSEDVKSYYTVHLLQLENInyienlwitlylkLLMLDVKRSLKSGETRTISHFHYTTWPD-FGVPESPASFLNFLFKVRESGSLN---PD
..|  . |....|.  .  . . ..|                .. |  ..   . |||.. .|..|.|.    || | ....... .||     .   |.
yge..ifveiveekqyanlkirtfkltkk.............ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpe

HGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
.|| |...| | .||| .  .| .| |.|| . ... . .  .|. | .|... .. .. |  . 
egPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 33-297 1.6e-45 150.1 In-house 29-275 (287) alignment 
Range on Protein: 33-297
Range on HMM: 29-275/287.0
PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA---ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPT
  . |.   . ..||| || |.|..|| | .      |||||  |   . . ..| .|||.. |   || .|..... .|... | ||.   || .||| 
tfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

DDQEMLFKetGFSVKLLSEDVKSyytvhllqleninyIEnlWITLYLKLLMLDVKrslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKV---RESG
 .. |.    |.|| ||. |.|.               |  . .  |.|. |. .      |.| .  ... .||| ... .  ... | ..|    |  
revPmrvG..Gysvvlldydike..............Pe..ygvralrlidletr......earvvkqldllswPdkvlaPtavglirfvldvkqhiela

SLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
    . || |.|...||||||..  . ...  .|.   ... .|.. .|.|| .|.|.. |||..| |.. 
rdasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 34-303 1.7e-44 147.3 In-house 40-292 (325) alignment 
Range on Protein: 34-303
Range on HMM: 40-292/325.0
HRVAKFPENRNRNRYRDVSPYDHSRVKLQ----NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMV--WQqkTKAVVMLNrIVEKESVKCAQYW
..||  |||...||...| ..|.||| |.    ... |||||| .  .  .  .. .| ||..|   .| .|  |.  .  ||.|| .....  .||.||
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvln.eldlgkdrcavyw

PtddqemlfKETGFSVKLLSEDVKsyytvhLLQLENInyienlwiTLYLKlLMLDVKRsLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVR---E
|        || | |... . .||      |  .|.|        . |..  .||||.  | ||||..  |.. .|.|.||.. ||.....|  |    |
p........kemgksktfGglevk......lrtieei........sdyvh.rvldvkq.vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavse

SGSL-NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIK
         .| ..|||||.||.|.|  . . |  . .   ..| ... ..|| |  ...| ||  . | |..|   . .
rvtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
0036282 (Phosphotyrosine protein) phosphatases II 66-290 2.8e-43 142.9 In-house 2-161 (174) alignment 
Range on Protein: 66-290
Range on HMM: 2-161/174.0
NDYINASLVDIEEAQRSYILTQGPLPntcchFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTddqemlfketgfsvkllsedvksyytvhllqlenin
.|||||| .|. .  . .|..||||.     || |..... ..||||.. .|....|| .|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

yienlwitlylkllmldvkrsLKSGETRTISHFHYTTWPDFGVPESPAsFLNFLFKVRESGSLnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEkGDDI
                     |.. ..|.. ...|. |||.|||...  .|.|.  |.|  |  ...|| ..|||||.||.||. . . .|....  . .
.....................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslv

NIKQVLLNMRKYRMGLIQTPDQLRF
.. ...  .|..|.| .|||.|.||
daldlvrelRlqrpgmvqtpsQyrf
0049772 (Phosphotyrosine protein) phosphatases II 30-311 8.5e-43 142.6 In-house 34-292 (314) alignment 
Range on Protein: 30-311
Range on HMM: 34-292/314.0
HDYPHRVAKFPENRNRNRYRDVSPYDhSRVKLQN---AENDYINASLVDIEeaqRSYILTQGPLPNTCCHF----------WLMV--WQQKTKAVVM---
 .. . ||....||..||| |. |.| .||.|..      |||||| ||     ...| |||||..|.. |          | ||  .....  .||   
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LNRIVEKEsvkcaQYWPTDDQEMLFketgfsvkllsedvksyytvhllqleNINYIENLWitlylkllmldvkrslksgeTR
                  |... ..       ...  |.|.|                           .. |  .|.                    .|
evladelsrLdaAlgKtpllildgng.....neptaadlellk..........................eelydpelf....................er

TISHFHYTTWPDFGVPeSPASFLNFLFKVRESgslnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMekgdDINIKQVLLNMRKYRM-----GLIQTPDQL
.. ..... .||...| ... |. ||  ..|     ...|| ..||.||.||.||| ... .. |.    .......|  .|. |.     |.|....|.
lgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqy

RFSYMAIIEGAKCIKGDSSIQKR
 | ..|. |  | .|. ... . 
efilealleylkflkkfyeylee
subfamily_PTPN3_pd Subfamily PTPN3 33-168 1.2e-42 140.8 In-house 32-169 (280) alignment 
Range on Protein: 33-168
Range on HMM: 32-169/280.0
PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQ----RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWP
   .|. ||| ..|||||..|||. ||||...|.|||||. |..|         || |||||..|. .|| |||.||.. .|||  .||.  ||| ||||
aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

TDDQEMLFKetGFSVKLLSEDVKSYYTVHLLQLENINYIE
. ..|. .   .||||. .|| .. | .  | |.. .  |
etedeleyg..efsvkcekedetksyvlrelvlkdketke
0051429 (Phosphotyrosine protein) phosphatases II 66-299 1.7e-42 141.3 In-house 4-225 (272) alignment 
Range on Protein: 66-299
Range on HMM: 4-225/272.0
NDYINASLVDIEeaqR------SYILTQGPLPNTCCHFWLMvWQQKTKAVVMLNRIVEKESVKCAQYWptddqemlfketgFSVKLLSEDVKSYYTVHLL
..||||. |.             .....||||.|. .|| . .... |..|.| . .|....|| .||               ...|  .. ....   |
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.............pgirylhlpilddsaptil

QLENINYIENLWITLYLKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPasFLNFLFKVREsgslnpdHGPAVIHCSAGIGRSGTFSLVDTCLVLM
..    ..   ...|.  | .| ... |. ||.|.. |.||| |||.|||...  .|..|  ...       .|| ..|||||..|.||..... .|  .
ygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgv

EKGDDIN--------IKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGA
.. . ..        . ...  .|..|.| .||..|..| |.|..| .
sletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0046846 (Phosphotyrosine protein) phosphatases II 65-297 8.2e-42 138.2 In-house 11-171 (176) alignment 
Range on Protein: 65-297
Range on HMM: 11-171/176.0
ENDYINASLVDIEEaqrsYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTddqemlFKETGFsvkllsedvksyytvhllqleni
  |||||.|..       .| ||||||.|. .|. |..... .|||.|.  ||....||..|||       ... |.                       
dldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe......leklgi.......................

nyienlwitlylkllmldvkrslksgetrtisHFHYTTWPDFGVPESpASFLNFLFKVRESGSLNpdhGPAVIHCSAGIGRSGTFSLVDtclvLMEKGDD
                                ..... |||.|||.. . .|..|  .||  . .   || ..||||||||.||. . .    |.|.. .
................................qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekg

INIKQVLLNMRKYRM-GLIQTPDQLRFSYMAIIE
... ..|  .|..|. | .|||.|.|| |... .
lsveealalvreqRplgavqtpeQyrflyefell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 41-296 9.1e-42 137.8 In-house 47-284 (305) alignment 
Range on Protein: 41-296
Range on HMM: 47-284/305.0
ENRNRNRYRDVSPYDHSRVKLQNA-ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQ-EMLFKE
.....|||.||   |. ||||...   .|| |  |      . .| || || .||  || | .|.| .|. ||  ..|| . ||..|....|. .. |.|
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

TGFSVKLLSEDVKsyyTVHLLQleninyieNLWITLYLKLLMLDVkrslKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVResgslnPDHGPAVIH
 |  . .  |  .   |... .        .   ..    |...       ...| ..|.|.  ||| ||| .  . |..| | |      | .|| |.|
kgqkisvkfessv...tlkfrk........dakakvtetvlvieg....pgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvh

CSAGIGRSGTFSLVDTCLVLMEKGDDIN-IKQVLLNMRKYRMGLIQTPDQLRFSYMAII
|||||||.|.  ...  |  .  |. |.  ...|  .|. |   ||| .|  | .  |.
csagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 30-297 1.3e-41 137.3 In-house 33-234 (392) alignment 
Range on Protein: 30-297
Range on HMM: 33-234/392.0
HDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKEsvkcaq
. ||..||. . | ..|||... ||| .||||    . ...||.||| ..  .....|| .||| . .   || ||.|... ...|.... | .      
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywptddqemlfketgfsvkllsedvksyytvhllqleninyienlwitlylkllmldvkrslKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRE-
                                                              |  ..||.. ||.| ||| .||.  .|.|.|. .|.  
..............................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

SGSLNpdHgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
 |.    | | .||||||.||.|    .|. .   .|   ... ... |.|. |  ..|| .|  | | |..|
fGqyt..h.pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0043147 (Phosphotyrosine protein) phosphatases II 65-292 1.2e-40 134.4 In-house 4-154 (172) alignment 
Range on Protein: 65-292
Range on HMM: 4-154/172.0
ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIvekesvkcaqywptddqemlfketgfsvkllsedvksyytvhllqleni
 .||||||..|.    ...| |||||.||. .|| |..... ...|.|..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

nyienlwitlylkllmldvkRSLKSGETRTISHFHYTTWPDFGVPeSPASFLNFLFKVRESGsLNPDHGPAVIHCSAGIGRSGTFSLVDTCLvlmekgDD
                      ......|.. ...|. |||.||| ... .|.||  ..|   .. ..|| ..|||||.||.||. . . .|       .
....................lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lg

INIKQVLLNMRKYRMGLIQTPDQLRFSY
... ...  .|. |.| .|.|.|.|| |
lsleeavalvrekRpgavqnpsqyrfly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 28-296 1.6e-40 133.7 In-house 26-290 (301) alignment 
Range on Protein: 28-296
Range on HMM: 26-290/301.0
ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA------ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESV
| .| .  |    ||.. ||......||. |. |..       ...||||| .|    .. .| .|||. .|   || ..||.|. ..||.    |.   
egedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtks

KCAQYWPTDDQEMlFKETGFSVKLLSEDVKSYYTVHLLQLENINYIENLWITLylkllMLDVKRSLksgETRTISHFHYTTWPDFGVPESPASFLNFLFK
|| ||||. ..|   ..  |.|.| .| |   ...  |..   .  .|  |       ...||..    .....  .. | ||. ||   |.  |. . .
kceqywpnseaes.eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyier.....kfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqvidd

VRESgSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
|       .. || |.|||....|||..  |.  |        ... ||   .|. ..| ..| .|  . | .| 
vihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 35-288 9.3e-39 128.2 In-house 34-266 (307) alignment 
Range on Protein: 35-288
Range on HMM: 34-266/307.0
RVAKFPENRNRNRYRDVSPYDHSRV--KLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD-D
 |  |  | ..|||.||   |..|.  |.. .  ||| |  . |    . .| .|||| ||  .|| |. |.| ..|.|| ...|   .|| |||| .  
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

QEMLFKETGFSVKLLSEDVKsyytvhllqleNINYIENLwitlyLKLLMLDVKRslkSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVREsgslnpD
|.. | |.. .. .    .|           ..   |.|     ...  |.|.    ....|||.|. .. ||| |||.   . .|.|  ||       |
qklvfgeapntisvanlgak...........klapdedl.....invttlkvdw...aqksrtiqhlqwenwpdrgvpqinltainlleavry......d

HGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDI-NIKQVLLNMRKYRMGLIQTPDQL
. | |.|||||.|||||   .      | .| .  ..|... ..|. |   |||  | 
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 42-301 6.1e-38 125.4 In-house 48-281 (439) alignment 
Range on Protein: 42-301
Range on HMM: 48-281/439.0
NRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEkeSVKcaqYWPTDDQEMlFK
.. .|||.||...||.|| ||.        ||||  ..    .. || ||||  .|. .|| .|...||  .|||  .||  | |   |||.|.. . . 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve..syk...ywpsdaevc.yg

EtgFSVKLlseDvksyYtvhllQLENINYIenlwITlYLKLLmldVKRSlKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVrESGSLNPDHGPAVI
.   .|.    |          ..|  ||.    |   .|..    .|  ..   ||. .|||..|||  ||   .  |.||  . .|   . . || |.
d..iavrv...d....r.....nielpnyv....ir.gfkvf...nerd.ttekertvlqfhyiawpdknvpaqashvldflrai.nsandkeeygpvvv

HCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKC
|||||.||.||   .| .|  .   . ..|| ..  .|| |  ..|.  |  | | |..|  . 
hcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 27-163 1.3e-37 124.6 In-house 41-178 (298) alignment 
Range on Protein: 27-163
Range on HMM: 41-178/298.0
NESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVK
.| ..  ..||. |||...||| |. ..|.||| |..     | |||||| ..  . . ..|.||.||..|   || ||.... ...|||. ..|.. .|
seieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CAQYWPTDDQEmlfKETGFSVKLLSEDVKSYYTVHLLQLEN
. .|||.. .|   .   ..|.|||..... ..|  |....
yhkywPdegke...tygeitvsllskeefadlivrklkvsk
subfamily_PTPN9_pd Subfamily PTPN9 21-170 2.2e-37 123.7 In-house 21-173 (297) alignment 
Range on Protein: 21-170
Range on HMM: 21-173/297.0
LYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIV
 |.|||||.      ..| . | ..||| ||  ||..||.|.. .     |||||. ||  . ....| |||||..|.  ||.|||.|..  .||  |.|
eyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvv

EKESVKCAQYWPTDDQEMlFKETGFSVKLLSEDVKSYYTVHLLQLENINYIENL
|.  .||.||||......  . . .||. .. .... |.|. |...|..  |. 
ergrlkcgqyWpleeess.aefgdlsvsnveveeeedykvrvleiknvkteesr
subfamily_PTPN13_pd Subfamily PTPN13 34-166 8.6e-37 121.9 In-house 29-162 (273) alignment 
Range on Protein: 34-166
Range on HMM: 29-162/273.0
HRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENdYINASLVDI--EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD
 .|.|  ||...||||.| |||..||||..  . ||||||. .  .. . .||..|||||.|.  ||.|||.||.. ..|.   .||. ||| .|||   
cevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

QEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINY
.. |  .  . |.||    .. ..|. |...... 
nkklkvsnrlevellkvqkldgfvvralavkdses
0049260 (Phosphotyrosine protein) phosphatases II 81-292 1e-36 121.3 In-house 9-143 (152) alignment 
Range on Protein: 81-292
Range on HMM: 9-143/152.0
RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWptddqemlfketgfsvkllsedvksyytvhllqleninyienlwitlylkllm
. .| ||||.|||. .|| |..... ...|||.. .|.  .||.||.                                                     
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................................

ldvkrslksgetrtisHFHYTTWPDFGVPESPASFLNFLFKVRESgsLNPDHGPAVIHCSAGIGRSGTFSLVDTCLvlmekgDDINIKQVLLNMRKYRMG
                ..... |||.|||...  .| .|  ...   .  ..|| ..|||||.||.||. . . .|       ........  .|. |.|
................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpg

LIQTPDQLRFSY
 ...|.|||| |
avpnpgqlrfly
subfamily_ptpA1_pd Subfamily ptpA1 41-264 1.2e-35 118.1 In-house 46-258 (418) alignment 
Range on Protein: 41-264
Range on HMM: 46-258/418.0
ENRNRNRYRDVSPYDHSRVKLQNA---E-NDYINASLVDIEEaQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDdqemlF
 | ..||| .. | .|.||.|..    | .|||||  .|     . .| |||||||| . || |||... . .|||.|  |.  .|| .||| .      
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq.....i

KETGFSVKLLSEDVKSYYTVHLLqlENINYIENLWITLYLKLLMldvkrslkSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG-SLNPD---H
    ||.    ..|   |.| |.  | |.  |   ||  ..| .         |||| |....|  |||. .|.    | ..|. . .    . |     
ggeqfsiygngnevfgtysvelv..eviqdpereiitrnirltf........egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

GPAVIHCSAGIGRSGTFSlvdTCLVLMEKGDD
 | ..|||||.||.|||    |....|.| | 
vpiivhcsagvgrtgtfc...tavimmkkldh
subfamily_PTPN12_pd Subfamily PTPN12 28-163 4e-35 116.1 In-house 26-165 (290) alignment 
Range on Protein: 28-163
Range on HMM: 26-165/290.0
ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKC
... |.  ... .||...|||.|. |||.|||.|..     ..|||||...   | . .|| .|||||.|   || |.|..... |||. |.|| .  ||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

AQYWPTDDQEML-FKEtgFSVKLLSEDVKS-YYTVHLLQLEN
..|||   .| | | |  |.|.| .|.  .  ...  |..|.
erYWpeegeeelefge..fevtleeekavdddflirtLkvea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 26-164 7.5e-35 115.5 In-house 31-169 (318) alignment 
Range on Protein: 26-164
Range on HMM: 31-169/318.0
RNESHDYPHRVaKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESV
|.|..   ..    | |...||| .. .|||.|||||.     . |||||. .|  .....|| .|.|||.|.  || |||.|... .||| ...|.  .
rseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergka

KCAQYWPTDdQEMLFKEtgFSVKLLSEDVKSYYTVHLLQLENI
|...||| . . . ...    |.| .|   |.|..  ..... 
kvhryWPsk.gsrsygk..lvvelkeevelsdyvlrefkvtrt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 35-295 3e-34 113.4 In-house 36-267 (288) alignment 
Range on Protein: 35-295
Range on HMM: 36-267/288.0
RVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD-DQE
 . .| .|  |.||...   | .||||..  . ||.| .|  .. .|  | .| ||  |   .| |. ..  . .|||....||   | |.|.|.   ..
iidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

MLFKETgfsvkllsedvksyytvhllqlenINYIENLWiTLYLKLLMLDVKRSLKSGETRT-ISHFHYTTWPDFGVPESPASFLNFLFKVresgslNPDH
. ..                           . . .   .   ||. . . |  | ||..  . . |.  |.| ||||.  |.|..|  .      .  .
arigrl........................ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslq

GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI
 | |.|.|||.||.||. |.   |. .   |.. |...| ..|. |.  |||  |  . .  .
kPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 41-296 9.8e-34 111.6 In-house 32-256 (267) alignment 
Range on Protein: 41-296
Range on HMM: 32-256/267.0
ENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKEsvkCAQYWPTDdqeMlfketG
.|..|||. |. |||..|| |.. |..||||| |.  . .. .|.||.|| ||  .|. .. .||   .|.| .. . .     ..||     |     |
knqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPk...m.....g

FSVKLlsEDVksyYTVHLLQLENINYienLWITLYLKLlmldvkrslKSGETRTISHFHYTTWpdfGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCS
 . |   .|.      | |. |. .|     ||| ||.         |   .. .. ..|  |    .      .|. || .     |.    | |..||
qakky..qdl...tvehslekeendy...qiitlelkf.........knesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacs

AGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
.|.||||||  .|. |  . . .  .| . |...|. |.||..| ..  . .  . 
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 35-162 3.4e-33 109.9 In-house 2-129 (250) alignment 
Range on Protein: 35-162
Range on HMM: 2-129/250.0
RVAKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVkCAQYWPTD
 ||| |.|...||| |. ..|.||| |.. .     |||||| ..  . ....| |||||..|  .|| ||...|....|||. ..|.| . . ||||..
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

DQEMLfkeTGFSVKLLSEDVKSYYTVHLLQLE
  |      .  |.|||..... ||.. |.| 
kaeky...Gdvtvsllskeefadytkrklkls
PTPc_DSPc_SM00012 194-297 1.5e-32 107.3 In-house 1-105 (105) alignment 
Range on Protein: 194-297
Range on HMM: 1-105/105.0
TISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG-DDINIKQVLLNMRKYRMGLIQTPDQLRFSY
|..|.|||.|||.||||.. |.|..| .|... . . ...| |.|||||.||.||| ..|..|  .||. . ..|.|..  .||.|.|..|| .|  | |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

MAIIE
.|..|
ralle
0051082 (Phosphotyrosine protein) phosphatases II 66-296 2.1e-32 107.1 In-house 3-150 (151) alignment 
Range on Protein: 66-296
Range on HMM: 3-150/151.0
NDYINASLVDIEeaqrsYILTQGPLPntccHFWLMVWQQKTKAVVMLNRIVEKEsvKCAQYWPTDDqemlfketgfsvkllsedvksyytvhllqlenin
.||||.| |.       .....|||.    .|. ...... |..|.|.  .| .  .|..|.|  .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

yienlwitlylkllmldvkrslksgetRTISHFHYTTWPDFGVPESPASFLNFLFKVREsgslnPDHGPAVIHCSAGIGRSGTFSLVDTCLvLMekgddI
                           ... |.... |||.|.|.|....|.|| ....     ...|| ..|||||.||.||. ... .| |.     .
...........................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml.lg.....v

NIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
.. ..|  .|..|.|..|...| .| ..|..
sleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 40-297 2.9e-32 106.8 In-house 33-268 (285) alignment 
Range on Protein: 40-297
Range on HMM: 33-268/285.0
PENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIE-EAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMlfke
  | . ||| ||   . .|| |.| . ||| || . .  . | .|| ||||||.|   || |..|.|   |.||  ..|    ||| |.|    |.    
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev....

tgfsVKLlsedvkSYYTVHLLQLENinyiENLWITLYLKLLMLDVKRslKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVResgSLNPDHGPAVIH
    ||.        | . | . ..    | .  |..  | ... .    | |   . | .   |||   ||    ....   |.    .||   | ..|
....vkf......gkyeitltecke....eaiagtilnaltvinted..asseplymnhvqvpwwpdqlapedarpmielykwvk...kvnpkekpicvh

CSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
||||.||. ||  .| . . . .  .|.. ... .||  |.  .|.  |. | |. ..|
csagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 26-165 4.3e-32 106.2 In-house 33-167 (287) alignment 
Range on Protein: 26-165
Range on HMM: 33-167/287.0
RNESHDYPHRVAkfPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQ
 .. ..  | .|  ..|...||.... ..|  || |.. ..|||||. .|  . .. .|....|. ||   || ...... .|.||| .  |..  .| |
tqredevthnia..sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyq

YWPTDDQeMLFKEtgFSVKLLSEDVKSYYTVHLLQLENIN
|||...  ... |  ....||.|.|.. |..  |...| |
yWpeeks.vvlGe..yniellneevnagyierklevknkn
subfamily_PTPN13_pd Subfamily PTPN13 186-298 5e-32 106.3 In-house 159-268 (273) alignment 
Range on Protein: 186-298
Range on HMM: 159-268/273.0
SLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVResgSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTP
 ..|||.| ..|.....||| ||| |.|..|.|. .||   .|. |.|| |.|||||||||||.  .|. | |.|.  ....|... ..|. | |..|| 
dsesgesrevahlnfvkwPdhgvPssaaellqfvaevr...rlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtk

DQLRFSYMAIIEG
||  | | ||.| 
dqyifvykailev
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 43-284 5.6e-32 105.6 In-house 56-274 (305) alignment 
Range on Protein: 43-284
Range on HMM: 56-274/305.0
RNRNRYRDVSPYDHSRVKLQN-AENDYINASLVDIEE-AQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETG
  .|||.||   |.| |||.. .  ||| |  |      .. .| .|||| .|  .|| || |.| . .||| . ||   .|||||||.   | |   .|
itknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg

FSVKLLSEDvKsyyTvhllqLENinyIENLWITlylkllMLDVkrSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgslnpdHGPAVIHCS
  |. .|   |         .|      .. ||      .|..  .   ... .. |...| ||| |||    . |..|  .| |      . | |.|||
ivvenvsgs.k...p.....mer...daeiqit......llnl..tysgdqkmsvrhlqwtewpdrgvppckltslellsairgs......kvpivvhcs

AGIGRSGTFSLVDTCLVLM-EKGDDINIKQVLLNMRKYRMGLIQT
|||||.||   ..  |  . |. .   . ...  .|  |   ||.
agigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqn
subfamily_PTPN9_pd Subfamily PTPN9 186-300 6.6e-32 105.7 In-house 166-291 (297) alignment 
Range on Protein: 186-300
Range on HMM: 166-291/297.0
SLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL-----------NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNM
  | .|.|...|| ...|||.|||.| ||.|..| ||||  .|           .|.  | |.||||||||.|||  .| ||  .|. . ... ...  .
nvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkll

RKYRMGLIQTPDQLRFSYMAIIEGAK
|. |   ||||.|  | |.|..| |.
rtqrafsiqtpeqyefcylavleyal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 43-290 9.7e-32 104.9 In-house 51-272 (301) alignment 
Range on Protein: 43-290
Range on HMM: 51-272/301.0
RNRNRYRDVSPYDHSRVK-LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQemlfketgf
....||  |    .. |. ... .   | |  .. .   . .| |||||.||.  || |. | . . .||| . |||.  ||..| |.. .         
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.........

svkllsEDVK-SYYTvhlLQLENINYIENLWITlylkLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgslnpdHGPAVIHCS
      |...   ..   ....| ..| |  |.       |.|. | .  .|||. |. |..|.| |||.| |   ...  |..|      . | |.|||
......ekldigrfk...ikiknkelilnkkis....krtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks......ekPivvhcs

AGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRF
|||||| .|   .     .|    |.... | ..|. |   .||  || .
aGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 24-295 2e-31 104.0 In-house 31-340 (350) alignment 
Range on Protein: 24-295
Range on HMM: 31-340/350.0
EIRNESHDYphRVAKFPENRNRNRYRDVSPYDHSRVKLQ------------NAENDYINASLVDIE----EA--QRSYILTQGPLPNTCCHFWLMVWQQK
..  .| |.   ...  |   .|||... ||.||||||.               ||||||. . ..    |   .  || ||.|||.|   |. .. . |
dsespsnDv..ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnk

TKAVVMLNRIVEKESVKCAQYWPTDDQE---MLFKETGFSVKLLSEDVKSYYTVHLLQLENINYIENLWITLYLKLLmlDVKrsLKSGETRTISHFHYTT
 | ...|.  || .  || .||.  . .   . ....  ..    . ..    |.    .| |  ..  .  . .|   ...  | . .   . ....  
vkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnslt..ait..laasdPyvvyqlqvkn

WPDFGVPESPASFLNFLF--------KVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLV-------LMEKGDDI--------NIKQVLLNMRKYRM
|.| ..   | |.|. |          . || . |    | ..|||||.|| ||.  .|  |        | ..   .         |.......|| |.
WkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqri

GLIQTPDQLRFSYMAI
 ..|. ||  | | |.
smvqnldqfifiYeal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 41-298 2.2e-31 103.7 In-house 42-275 (312) alignment 
Range on Protein: 41-298
Range on HMM: 42-275/312.0
ENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWptDDqeMlfkeTG
  .. ||| ..  .|  |  |   || || | .| |      .. ||||| |||.||| ..    . ....|  .||  | |||.|    |  .     |
kfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sd..i....vg

FsVKLlsEDVKSyYTVHLLQLEnINYIENLWITLylKLLMLDVKRslkSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVREsgslnpDHGPAVIHCS
| |.|  || .  || .  ..| |    .  ||   ..| . ||    .|.   . |. ...||| |.|.|  . | .|  |.       |. | . |||
f.vdl..edhrv.yteycteie.iggkskdkith..rvlkvvvka...tgqesklnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcs

AGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEG
||.||.||. |... .  . .    |.|.... .|| |   ...  |  ..  ...| 
agvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 30-149 7.5e-30 98.9 In-house 32-154 (315) alignment 
Range on Protein: 30-149
Range on HMM: 32-154/315.0
HDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQ
  |..|||. ..| ..|||... |.|..||||    .. ..|||||| .   . ...|| .||||. .   || ||.|.|. ..||..   | . .||.|
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPTDDQEMlFKETGFSVKLLSED
|||  . .   .   ..|.||| .
ywPdrkads.vefGsikvellsle
0044763 (Phosphotyrosine protein) phosphatases II 53-290 1.7e-29 98.1 In-house 1-162 (178) alignment 
Range on Protein: 53-290
Range on HMM: 1-162/178.0
PYDHSRVKLQNAEN----DYINASLVDieeaqRSYILTQGPLpntcCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQemlfketgfsvkllse
|.|..||.|.| |.    |||||| ..       ..|.. |      ... ...... ...|.|.  .|   .|| .|||..                  
pldrtrvllsnleglersdyinaseil.....pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

dvksyytvhllqleninyienlwitlylkllmldvkrslksgetrtiSHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnPDHGPAVIHCSAGIGRSGT
                                                ..... .||.|||.... ||.|.  ..|  .  ...|| ..|||||.|||||
...............................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgt

FSlvdtCLVLMEKGdDINIKQVLLNMRKYRMgLIQTPDQLRF
.     .. || |  .... ...  .|..|.  ...|.|||.
lv....aaylmkkl.glsleeaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 38-290 3.5e-29 96.3 In-house 48-281 (310) alignment 
Range on Protein: 38-290
Range on HMM: 48-281/310.0
KFPENRNRNRYRDVSPYDHSRVKLQ---NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDqem
 . ..  .||| ||   | |||||.      .||| |  |  .  . ..| .||||  |   || |..|........| ...|.   ||  |||.     
aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg...

lFKETG--FSVKLLSEDVKSYytvhllqlEninyIENLWITLYLKLLMLDVKRSlkSGETRTISHFHYTTWPDFGVPESPASFLN--FLFKVResgslnp
   ||     |  |||  . .        |    | || .|.    . .| . .    .   .|  ..  ||| |||.     .   .| .||       
.vtetygcirvtnlsesseef........e....icnlavtfvpdnvpvdeqpa..nlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr.......

dHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRF
 ||| |.|||||..| ..   ..  .  ...|. .....|  ...| |.  |||. |  .
.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 30-149 8.3e-29 95.0 In-house 25-153 (515) alignment 
Range on Protein: 30-149
Range on HMM: 25-153/515.0
HD------YPHRVAKFPENRNRNRYRDVSPYDHSRVKL----QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
||      ||  ||.   | ..|||... ||| .||||    .| ..||.||| .   .....|| .|||.. .   || .|.|... ...|...  | .
hdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegd

SVKCAQYWPTDDQEMLfKETGFSVKLLSED
 .||..|||    . . |   ..|.|.| .
kikcgkyWPdkpgdsv.kfGsikvelvsle
subfamily_PTPN3_pd Subfamily PTPN3 188-297 1.1e-28 95.0 In-house 166-273 (280) alignment 
Range on Protein: 188-297
Range on HMM: 166-273/280.0
KSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLnpDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQ
.. | |.| .. |. ||| |||...|.||.|. .||.  |   .. | |.||||||||.| . |..|.| |.|. ..... ... .||  |. |.||..|
etkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasq

LRFSYMAIIE
 .|   ||..
ykfvCeailk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 33-211 2.4e-28 93.9 In-house 24-182 (297) alignment 
Range on Protein: 33-211
Range on HMM: 24-182/297.0
PHRVAKFPENRNRNRYRDVSPYDHSRVKLQN--AENDYINASLVDI--EEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWP
   .|| .    .|||||.  .| .||||..  .|.|||||  |    |||.  |||.|||| .|   || .|..|  ...||. .. |    ||| |||
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

TDDQEMLfKETGFSVKLLSEDVKSYYTVHLLQLeninyienlwiTLYLKllmldvkrslksGETRTISHFHYTTWPDFGVPES
  .|| | | . . |. ||.    . .|.| .|           .|. .             |.| . |  . .||| |||  
svvqerl.kagdvvveflsstsdefdrviltel...........qliyr............sesrvvrhvqflswpdhGvpsd
subfamily_PTPRN_pd Subfamily PTPRN 15-173 3.4e-28 93.2 In-house 32-190 (297) alignment 
Range on Protein: 15-173
Range on HMM: 32-190/297.0
QRRWQPLYleiRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASL-VDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAV
...|. |    . |...  . ||| ..| ..||...| |||||||||..     ..||||||  .| .  . .|| |||||..| ..|| |||.| .  .
ekewealc...ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLNRIVEKESVKCAQYWPTDDQEMLfkeTGFSVKLLSEDVKS-YYTVHLLQLENINYIENLWIT
|.| |. |..  .|..||| . .|.      . |.|.|| . .  | |  . | |..  |   .|
vnltrleeegvkqckrywpdeGsevy...hiyevhlvsehiwcddylvrsfylknlqtsetrtvt
subfamily_PTPN12_pd Subfamily PTPN12 188-297 6.8e-28 92.4 In-house 165-275 (290) alignment 
Range on Protein: 188-297
Range on HMM: 165-275/290.0
KSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDD---INIKQVLLNMRKYRMGLIQT
...|.|..  |||| ||| |||.|. | |... .|||  .   .. | |.|||||.|| ||   .|    |....     ... ...|..|| |  |.||
aqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt

PDQLRFSYMAIIE
 .| .. |.|..|
keqyelvykavae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 181-302 1.8e-27 91.4 In-house 174-293 (298) alignment 
Range on Protein: 181-302
Range on HMM: 174-293/298.0
LDVKRSLKSgETRTISHFHYTTWPDFGVPESPASFLNFLFKVREsGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMG
| |... .. ..|.. ..|.|.||| ||||   | |..| |||     .  . | ...||||.||||||. .|. |  ..|   . . ||.  .|| |.|
lkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpg

LIQTPDQLRFSYMAIIEGAKCI
..|| .|  | |.|..|  .. 
avqteeqYvfiyeavlealdsf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 180-319 2.4e-27 90.8 In-house 163-303 (318) alignment 
Range on Protein: 180-319
Range on HMM: 163-303/318.0
MLDVKRsLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRM
 . |.|  .. |.|..  .|||.||| |||||.||.|... .|..   .....|| |.|||||.|| |.|  ||. |  ...   ... |.  ..|. | 
efkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrn

GLIQTPDQLRFSYMAIIEGAKCIKGD---SSIQKRWKELSKED
 ..|| ||  | | ...|  .. . .   | ...| .|| ..|
lmvqtedqyefiydvllealasgdtevdasdlrsrirelreqd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 188-303 7.8e-26 85.8 In-house 132-246 (250) alignment 
Range on Protein: 188-303
Range on HMM: 132-246/250.0
KSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQ
|  . |.. ..|...||| ||||   . |..| ||. |   . . .| ...||||.||||.|  .|. |  ..|   ... .|.  .|| |.. ... .|
kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqq.qagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleq

LRFSYMAIIEGAKCIK
  | |..|..  ....
yvfvyeiilkaldsve
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 38-297 2.2e-25 83.9 In-house 43-277 (303) alignment 
Range on Protein: 38-297
Range on HMM: 43-277/303.0
KFPENRNRNRYRDVSPYDHSRVKLQNaeNDYINASLVDIEEaQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFK
.| .| ..||. ||   |||.||| .    || || ....  ..  |||| ||. |.. || |. .|| | |..|    | ...     .| ... . |.
qfvknmdknrfvdvicldhskvklsd..ssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

ETGFSvkllsedVKSYYTVHllqleninyIENLWItlyLKLLmldvkrSLKSGETRTISHF-HYTTWPDFGVPES-PASFLNFLFKVRESGSLNPDHGPA
|           |  .  |          . . |    ||.|      |.  |. ... |  || .||   .|    . |.. .....       |  |.
ersir.......vgefkrve.........lgdgwv...lkvl......svsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstpt

VIHCSAGIGRSGTFSLVDTC-LVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|    .| ||.|||.| .|. | | ..   ... ..| |.|. |.  .|   |. . |  . |
vymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_PTPRN_pd Subfamily PTPRN 185-300 8.4e-25 82.1 In-house 179-293 (297) alignment 
Range on Protein: 185-300
Range on HMM: 179-293/297.0
RSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgsLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG-DDINIKQVLLNMRKYRMGLIQ
. |.. ||||.. ||. .||. ||| |. |.|.|  ||  |        | |.|||.| ||.|.. |.|  |  . ||  .|.|   |  .|  | ||..
knlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks..yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvk

TPDQLRFSYMAIIEGAK
| ||..| ..|..|  .
tkdqfefaltavaeevn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 30-133 2.4e-24 81.0 In-house 39-143 (297) alignment 
Range on Protein: 30-133
Range on HMM: 39-143/297.0
HDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAEN----DYINASLVDIeeAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESvKCAQ
  .|  ||.   | ...||... ||| |||||.  ..    ||.||| |     .  .| || | ..|   || ||........||||   |..  |||.
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPTDDQE
||. .   
yWsdkgvt
0048076 (Phosphotyrosine protein) phosphatases II 159-295 2.5e-24 81.0 In-house 17-139 (145) alignment 
Range on Protein: 159-295
Range on HMM: 17-139/145.0
LQLENINYIENLWITLYLKLlmldvkRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVREsgsLNPDHGPAVIHCSAGIGRSGTFSlvdtCLVL
   ... ....| ||. | |       | .....|.. ...|. |||.|||.... .|.||  ..|   . ...|| ..|||||.||.||.     .. |
ptaldlellkdlgittvlnl......tselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlv....aayl

MEKGDdINIKQVLLNMRKYRMGLIQTPDQLRFSYMAI
| . . ... ..|  .|..|.| ...|.|||| |...
mlllg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 188-300 1.3e-22 75.1 In-house 168-278 (315) alignment 
Range on Protein: 188-300
Range on HMM: 168-278/315.0
KSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgsLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQ
|| |.||.. |..| ||| ||..  .|.|... .|. .   .... . ..|||||.||.| .  .| ..  ..... ... ... |.|. |. |.|| ..
kseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee

LRFSYMAIIEGAK
  | | |. |  .
yafiydavledll
0048179 (Phosphotyrosine protein) phosphatases II 159-290 1.6e-22 75.2 In-house 25-136 (144) alignment 
Range on Protein: 159-290
Range on HMM: 25-136/144.0
LQLENINYIENLWITLYLKLLMLDvkrslksgetrtISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnpDHGPAVIHCSAGIGRSGTFSLVDtclvL
|.  .|... ||  . .   |               . ..... |||.|||.... .|.||  ..|  .   ..|| ..|||||.||.||. . .    |
lkklgittvinlteeyepeflere............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....l

MEKGDdINIKQVLLNMRKYRMGLIQTPDQLRF
| | . ......|  .|..|.| ...|.||||
mkklg.lsleealalvrsrrpgavpnpgqlrf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 189-298 3.3e-22 74.0 In-house 173-283 (297) alignment 
Range on Protein: 189-298
Range on HMM: 173-283/297.0
SGETRTISHFHYTTWPDFGVPE--SPASFLNFLFKVRESGSLNPDHgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPD
.  .| .  .... |||  |..  | .|.|...  ||.. | | .  | ..||.||.|| | .  .| ..  ... ....| ...  .|. |. |.|| .
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke

QLRFSYMAIIEG
| .| | |..| 
qykfvyvavlea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 187-298 4.9e-22 72.7 In-house 166-275 (515) alignment 
Range on Protein: 187-298
Range on HMM: 166-275/515.0
LKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSL-NpdHgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTP
||. ..||.  ||.| ||| |||.   |.| .. .|. . .  .  | | .||||||.|| | .  .| ..  ..... ... ... |.|. |. |.|| 
lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..h.pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtq

DQLRFSYMAIIEG
.|  | | |. | 
eqyafiygavled
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 37-171 1.7e-21 71.5 In-house 3-138 (239) alignment 
Range on Protein: 37-171
Range on HMM: 3-138/239.0
AKFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINAS-LVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD
||   |. .||| ..  |||||| |..      .|||||| | | . . ..|| ||| .  ..  || |.||..   .|||  ..|    || ||||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

QemlfKETGFSVKLLSEDVKSYYTVHLLQLENINYIENLW
     |   . | |   .| . | .. . . ..   |. .
s....kycnlrvtlrktevfadyiirtfvmsqvgqteery
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 81-297 1.8e-21 71.4 In-house 35-219 (255) alignment 
Range on Protein: 81-297
Range on HMM: 35-219/255.0
RSYILtqgplpnTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEM-LFKEtgfsVKLLSEDvksyytvhllqleniNYIENLWITLYLKLL
 .|.|       |  .|. .. |.||. ||||    |.. .|| .|.|.. .|   ...    |.. . .               .  . .  || . . 
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk...............ssadvvlrtleitst

MLDvKRslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLnpdhgpaVIHCSAGIGRSGTFSLVDTCLV----LMEKG--DDINIKQVLLN
. . |.     .|.|. |..|. |..   || .   || |  ||.| |.       |.|||.||||| .| |..         ...    ... ...| .
lge.kk.....kthtvkhysykGWieknaPelareilnilkvvrdsksv.......vvhCstGiGrsaafvlaelvyqkmirsldttetveldylsllee

MRKYRMGLIQTPDQLRFSYMAIIE
.|. | . |.|| || || . ...
lrskrkraihtPlqlafsilmvld
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 38-170 2e-21 71.2 In-house 3-136 (239) alignment 
Range on Protein: 38-170
Range on HMM: 3-136/239.0
KFPENRNRNRYRDVSPYDHSRVKLQNAE----NDYINAS-LVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQ
|   |. .||| ..  |||||| |..      .|||||| | | . . ..|| ||| .  ..  || |.||..   .|||  ..|    || ||||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

emlfKETGFSVKLLSEDVKSYYTVHLLQLENINYIENL
    |   . | |   .| . | .. . . ..   |. 
....kycnlrvtlrktevfadyiirtfvmsqvgqteer
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 41-138 2.4e-21 70.7 In-house 53-152 (290) alignment 
Range on Protein: 41-138
Range on HMM: 53-152/290.0
ENR--NRNRYRDVSPYDHSRVKLQNA-ENDYINASLVDIeeAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQE-MLF
.|   ..|||.||   | .|| |..  . ||. |  |.    .  .|||||.| .|   .| || |.|. |.|||  ..|.   ||.||.|  . | . |
kntefkknrykdvvcndktrvilkdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

KE
 |
Ge
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 57-296 5.5e-21 69.3 In-house 52-285 (302) alignment 
Range on Protein: 57-296
Range on HMM: 52-285/302.0
SRVKLQNAENDYINASLVDIEEAqrSYILTQGPLP-----------------NTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQ-EMLFKE
.  ||.. .||.||| .. ..|   ..|..|||.                  .|.  .| .. | ..  || |  .||.|  |||.|. .. . |. |..
tmaklvdfkndfinanvlkldei..kwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgr

TGFSVKLLSEDVKSYYTVHLLQLENINYIENlwitlylkllmldvkRSLKsGETRTISHFHYTTWPDFGVPESPASFLNFLfKVRESGSLNpdhgpAVIH
     . . .|.. .   . ..| .... ..               .  |    .|.. .....||| | |. . . |. | |  ||   |      ..|
ytvktvsvktdleeftdkksfklytveikne...............kkkk.kvkktvdilafsawpdhGapkeaytaldil.kfcesykkn.....vlvh

CSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
||||.||.||.  .   . |  | .  .. ...| .|. | | .|. .|| .  . . 
csaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 38-145 6.7e-21 69.2 In-house 33-144 (281) alignment 
Range on Protein: 38-145
Range on HMM: 33-144/281.0
KFPENRNRNRYRDVSPYDHSRVKLQN-----AENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQ
. | | ..||| ..   | |||.|.         ||| |  .     .| |||||||  .| . || |.||..| |.||| ...| .  |||.|.| . .
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EMLfKETGFSVKL
  | .   .||. 
ccl.qfdklsvsy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-308 1.3e-20 68.1 In-house 86-201 (440) alignment 
Range on Protein: 190-308
Range on HMM: 86-201/440.0
GETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLR
 |.||. ..||  ||| |||.  .  |...  | ||   .   || ..||||| ||.|    ||. |   .. |.|.|  .. .||. |  ..|||.|  
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqe.kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FSYMAIIEGAKCikGDSSI
| . |..||  |  ||. |
fvheavlegllc..gdtli
subfamily_egg_pd Subfamily egg 24-296 1.8e-20 67.9 In-house 21-267 (307) alignment 
Range on Protein: 24-296
Range on HMM: 21-267/307.0
EIRNESH-DYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVek
|. .||  . . . |   .|... | . |   | |||||.       .|.| |  |. .     .||.| || ||   || ||.|.. . .|||.  .  
evleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk..

ESVKCAQYWPTDDQEMLFK-ETGFSVKLLSEDVKS--YYTVHLLQLENINyienlwitlylkllmldvkrslksGETRTISHFHYtTWPDFGVPESPasf
|| .|  |||  ... |     .. .. |  | |.   ..|  |.|   .                         | | . |. .  .   .   ||   
eserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd........................deerflehwqg.dvnnssdvysp...

LNFLFKVRESGSlnpdhgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD--DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
|. | |.|.         |.|...  |. ...|.  ... |. . .|      ...    .|. |   .... .  | |  ..
lrvlrklrnlsk......pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_CG42327_pd Subfamily CG42327 41-225 1e-19 65.3 In-house 27-193 (319) alignment 
Range on Protein: 41-225
Range on HMM: 27-193/319.0
ENRNRNRYRDVSPYDHSRVKLQNA----ENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDqeml
  ....|. .| |  ..|| ||.     .. |..|| |   ..|. ||| .| .| ..   || .||.|... .| |  . |.   .||.|.|| .    
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke....

fkeTGfsvkllseDVKSYYTVHLLQLENINYIENLWITlylKLLMldvkRSLKSGETRTISHFHYtTWPDFGVPESPASFLNFLFKVRES
   |.        | .| |   |. | . .  ..  |.    ||.    . ..  |.| ..|. |  |.. .|| ..|...  |..||.|
...tl........dntslyGdilvtlkgrevkdryais...tlll....krvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 180-296 1e-19 65.3 In-house 171-276 (290) alignment 
Range on Protein: 180-296
Range on HMM: 171-276/290.0
MLDVkRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgslnpdHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRM
.| | |  .||    . |..  .|||  |. |  ..|  |. .|.        || |.||||||||.|||  ....| .. .| .... ..   .|. |.
tlsv.rdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrl

GLIQTPDQlrfsYMAII
. .|   |    |.|..
nsvqvdiq....ylalv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 181-303 1.3e-19 65.3 In-house 161-282 (287) alignment 
Range on Protein: 181-303
Range on HMM: 161-282/287.0
LDVKRSLKSGETRTISHFHYTTWPDFG-VPESPASFLNFLFKVREsgSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRM
|.||.. |.|.....  ...|.|.. | |.|  ...| .  ....     . ... |.|||...|||..|  ..| .   ..   |.. ||| ..|  ..
levknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkp

GLIQTPDQLRFSYMAIIEGAKCIK
| .|| .| .| . ...|  .. .
gsvqtveqykfindivleyldsfe
subfamily_hpo-7_pd Subfamily hpo-7 81-297 6.9e-19 62.8 In-house 38-225 (263) alignment 
Range on Protein: 81-297
Range on HMM: 38-225/263.0
RSYILtqgpLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEmlfKETGFSVKLLSEDVKSyytvhllqleninyiENLWITLYLKLLM
 .|.|    | .|   |. .. |.||. ||||    |.. .|| .|.|..  |   |     |.. . .|.|               . |  || |   .
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde...kqklanvnvcttkvqs...............dvllktlellstl

LDvKRslksgETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLnpdhgpaVIHCSAGIGRSGTFSLVDTCLV----LMEKGD--DINIKQVLLNM
 . |.     .|.|. |. |. |..   || . . || |  .|.| ||       |.|||.|||||  ||....        ... .  ...  ..| ..
ge.Kk.....kthtvkhysykgWiekndpelareilnilkvarnsksl.......vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleel

RKYRMGLIQTPDQLRFSYMAIIE
|. | . |.|| || || . ...
rssrkraihtPmqLafsilmvLd
subfamily_eak_pd Subfamily eak 35-297 1.5e-17 58.0 In-house 45-303 (332) alignment 
Range on Protein: 35-297
Range on HMM: 45-303/332.0
RVAKFPENRNRNrYRDVSPYDHSRVKLQNA---ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDD
....  |. |||   .. |||.  |.| ..   .. ||||||..  |  | ||||  .  .    || || .||. |.|.|   ||..  |  .|.| . 
setarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

QEMLfKETGFSVkllseDVKSYytVHLLQLENINYIENLWITLYlKLLMLDVK--RSLKSGETRTISHFhYTTWPDFGVPESPASFLNFLFKVRESGSLN
.| | |   . |     . |..  |.  .||  ... .     . ..|   |     ..    .    . . .  . ||.       . |  .       
reel.kfGildv.....erkef..vkrniletrllelskGneth.rvlhykvfGwtettlpkyedflal.rkvmkevGvlllivmksallsstlkkyiht

PDHGPAVIHCSAGIGRSGTFSLVDTCLVLME--KGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
|     .| .. |  |.|.| ..|  . |..  | .   .....| ... |.  . .  |  | | ....
ppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivld
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 189-297 2.2e-17 58.0 In-house 132-238 (239) alignment 
Range on Protein: 189-297
Range on HMM: 132-238/239.0
SGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgSLnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQL
  | | . ..|.| ||| |||.  .. | .  |. .  || |   | |||||||.||.|.| ..|. |   .|   ..| . .  .|. |  ..|| .| 
qteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

RFSYMAIIE
 | ..|..|
vfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 189-297 3.3e-17 57.4 In-house 133-239 (239) alignment 
Range on Protein: 189-297
Range on HMM: 133-239/239.0
SGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESgSLnPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQL
  | | . ..|.| ||| |||.  .. | .  |. .  || |   | |||||||.||.|.| ..|. |   .|   ..| . .  .|. |  ..|| .| 
qteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

RFSYMAIIE
 | ..|..|
vfihlavle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 65-274 1.9e-15 51.1 In-house 89-307 (349) alignment 
Range on Protein: 65-274
Range on HMM: 89-307/349.0
ENDYINASLVDIEE--AQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTD---DQEMLFKETGFSVKLLSEDVKSYYTVHLL
 .|||||  . . .  ... || || ||| |   |. ..  .. | |. ||   |..  || .||      . .. ....   .  .   .  ..||.  
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdt

QLENINYIENlwitLYLKLLMLDVKRSLKSGETRTISHFHYTTWPDFGVPESPASFLNFLFkVRE--------SGSL-NPDHGPAVIHCSAGIGRSGTFS
. .| |  .|      |    .|    |.. .   .  . .  |.| ..   | |.|. |  |..           | . .  . ..||||| ||.|.. 
dndndnnkkn....CdlpddddddaillavekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlv

LVDTCLVLMEKGDDINIKQVLLNM
 .|  | ..|   .   |  | ..
tldlllsileplqnesnkiklqal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 189-287 6.8e-15 49.5 In-house 163-257 (281) alignment 
Range on Protein: 189-287
Range on HMM: 163-257/281.0
SGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnpdhgPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD-DINIKQVLLNMRK-YRMGLIQTPD
 |||| |.|. .  |||. ||||   .|. | |.|   .      | |||||||.|||||.  |. .|  .       .|||..  .|   |   .|| .
egetrlithwlwkewpdwqvpessevmlkilrkirarst......ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlq

Q
|
q
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 36-130 9.9e-15 48.7 In-house 45-141 (302) alignment 
Range on Protein: 36-130
Range on HMM: 45-141/302.0
VAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTC---CHFWLMVWQQKTKAVVMLNRIVEKESvKCAQYWPTD
   | .| ..|.  ||  .|. .|||......|.||| |.. | .|| ||.| |  ..     .|| ||.|.| . ||.| .  | .     ...|. 
CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 37-146 3.2e-13 43.9 In-house 91-196 (244) alignment 
Range on Protein: 37-146
Range on HMM: 91-196/244.0
AKFPENRNRNRYRDVSPYDHSRVKLQNA--ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIvEKESvkcaQYWPtDDQEM
|  |.|  .||     |.| .|| | ..   | |||||.|        ||||| || .|   || |. ... . .|.|  . |.|     .||| | . .
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.eeed....eywp.dsepl

LFKETGFSVKLL
 . |   .| | 
ewyeeditvtlt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 190-296 2.4e-12 41.6 In-house 155-256 (290) alignment 
Range on Protein: 190-296
Range on HMM: 155-256/290.0
GETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSlnpdhgPAVIHCSAGIGRSGTFSLVDT-CLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQL
.|  |. |  .  | .  |.|.. ..|. . ||. |..      |...||  || || ... ..  .  ..|. .......|| ..|| |  .|... .|
eeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalel

RFSYMAII
 |   .|.
afvdagiv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 28-124 2.9e-12 40.7 In-house 20-119 (332) alignment 
Range on Protein: 28-124
Range on HMM: 20-119/332.0
ESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKL--QNAENDYINASLVDIEEAQRSYILTQGPLPN-TCCHFWLMVWQQKTKAVVMLNRIVEKESVKCA
 .  ||    || .| . ||   .  .|||||.|  |. ..|. ||| ||    . .||..| |. . |   || || ..|   ....  | ||.  |. 
samtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 53-162 2.9e-11 37.8 In-house 4-103 (130) alignment 
Range on Protein: 53-162
Range on HMM: 4-103/130.0
PYDHSRVKlqnaENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIvEKESvkcaQYWPtDDQEMLFKETGFSVKLLSEDVKS
... ||..    .|.|||||.| . .  . |.||| || .|. .|| |. ..    .|.|  . |.|     .||| | . . . |.   | |   |   
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.eeed....eywp.dsePlewyeediivtltdrdefk

YYTVHLLQLE
.     |. |
nikasnleie
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 47-120 6.9e-11 36.2 In-house 42-124 (347) alignment 
Range on Protein: 47-120
Range on HMM: 42-124/347.0
RYRDVSPYDHSRVKL---------QNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
| .||   | .|| |          .  . ||||| . ...|.. ||||| |||.|   || ||   |   || .   .. |.
rskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdea
PTEN_1 192-291 7.5e-10 33.9 In-house 92-185 (196) alignment 
Range on Protein: 192-291
Range on HMM: 92-185/196.0
TRTISHFHYtTWPDFGVPeSPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFslvdTCLVLMEKGDdINIKQVLLNMRKYR-MGLIQTPDQLRF
 . ... |.  ..|.|.| | .... .. .. |. ...|... ...|| ||.|||||      .  ||.||   . .. |  .|. |  | ...| | |.
ksgveylhf.pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtv....vaayLmykgk.ltadeAlelvrekRppgapnspsqerl

S
 
l
subfamily_CG42327_pd Subfamily CG42327 231-301 8.4e-10 32.8 In-house 246-317 (319) alignment 
Range on Protein: 231-301
Range on HMM: 246-317/319.0
DHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG-DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKC
..|| |.||| |.||.|.    |  .  .|.    ..| |..  .|. |   ..| .|  | |  . | || 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 229-297 1.4e-09 32.2 In-house 225-293 (297) alignment 
Range on Protein: 229-297
Range on HMM: 225-293/297.0
NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIE
 |   . ..|||||.||||   | |. |  . |.   ... .|  .|. |  |.|| .|  . | |...
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 79-163 2e-09 31.9 In-house 3-86 (199) alignment 
Range on Protein: 79-163
Range on HMM: 3-86/199.0
AQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMlFKETGFSVKLLSEDVKSYYTVHLLQLEN
.|| || || || .| . || |||.  .  .||.|    .  .  . |||| .     | . .||   .  .|. ||.  | | |
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttktittkpdytitaliltn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 79-163 2.4e-09 31.6 In-house 2-85 (198) alignment 
Range on Protein: 79-163
Range on HMM: 2-85/198.0
AQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMlFKETGFSVKLLSEDVKSYYTVHLLQLEN
.|| || || || .| . || |||.  .  .||.|    .  .  . |||| .     | . .||   .  .|. ||.  | | |
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttktittkpdytitaliltn
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 199-296 2.5e-09 31.0 In-house 187-282 (302) alignment 
Range on Protein: 199-296
Range on HMM: 187-282/302.0
HYTTWPDFGVPESPASFLNFLFKVreSGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAII
. | |..  ||.. |.  .   ||    .  .   ..||    |.|| |.|  . . .  ..||.. |||... ..|. |   ... .|  . |.|..
vltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
0038934 (Phosphotyrosine protein) phosphatases II 197-292 6.4e-09 31.2 In-house 81-170 (194) alignment 
Range on Protein: 197-292
Range on HMM: 81-170/194.0
HFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHgPAVIHCSAGIGRSGTFslvdTCLVLMEKGdDINIKQVLLNMRKYRMGLIQTPDQLRFSY
...   .||.|.. | .  |.||  | |  . .|..   ..|| ||.||.||.     .  |...  ... .. .  .|  | | |...|.|.  .
eylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtl....vaaYLiyrl.gmsaeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 32-215 3.4e-08 26.5 In-house 16-160 (169) alignment 
Range on Protein: 32-215
Range on HMM: 16-160/169.0
YPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINAslvdieeaqrsyiltqgplpntcchfwLMVWQQKTKAVVMLNRIVEKEsvkcaQYW
|   .|..  |  .||        | |||||       .|||||                            |.|.  .  .|.|    .|.     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfw

PTDDQEMLFKetgfSVkLLSED-VKSYYtVHLLQLE-NINYIENLWitlylKLLMldVKRSLKSGETRTISHFHYTTWPDFGVPESPASF
|  ..  |      .| .| |    | | |   ... | . .| |.     .. .  |. | ..  |. .| .||.|||. |||.||   
pekedyqlhp....av.ilGewytdsly.vrtdkvhpntsgveglf.....evsl..vihsydddvteqlsllhystwpqngvpqspvhv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 189-292 4.7e-08 27.4 In-house 90-196 (198) alignment 
Range on Protein: 189-292
Range on HMM: 90-196/198.0
SGETRTISHFHYTTWPDFGVPESpASFLNFLFKVRESGSL--NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLME--KGDDINIKQVLLNMRKYRMGLIQT
   || |||. .|.| .   |.  | |. |.   ||      .    | ..||| | | .| |  .|  .   |  |   ... .|   .|. | |.| .
ppstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

PDQLRFSY
 ..  | |
lqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 189-292 4.8e-08 27.4 In-house 91-197 (199) alignment 
Range on Protein: 189-292
Range on HMM: 91-197/199.0
SGETRTISHFHYTTWPDFGVPESpASFLNFLFKVRESGSL--NPDHGPAVIHCSAGIGRSGTFSLVDTCLVLME--KGDDINIKQVLLNMRKYRMGLIQT
   || |||. .|.| .   |.  | |. |.   ||      .    | ..||| | | .| |  .|  .   |  |   ... .|   .|. | |.| .
ppstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

PDQLRFSY
 ..  | |
lqhynfiy
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 32-215 7.6e-08 25.5 In-house 17-161 (169) alignment 
Range on Protein: 32-215
Range on HMM: 17-161/169.0
YPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNA----ENDYINAslvdieeaqrsyiltqgplpntcchfwLMVWQQKTKAVVMLNRIVEKEsvkcaQYW
|   .|..  |  .||        | |||||       .|||||                            |.|.  .  .|.|    .|.     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfw

PTDDQEMLFKetgfSVkLLSE-DVKSYYTVHLLQLENINYIENLWitlylKLLMldVKRSLKSGETRTISHFHYTTWPDFGVPESPASF
|  ..  |      .| .| |    | |        |.. .| |.     .. |  |  | ..  |  .| .||.|||. |||.||   
pekedyqlhp....av.ilgewytdslyvrtdkvhantsgveglf.....evsm..vihsydddvteklsllhystwpqngvpqspvhv
subfamily_CDKN3_pd Subfamily CDKN3 183-290 8.7e-08 26.0 In-house 88-187 (202) alignment 
Range on Protein: 183-290
Range on HMM: 88-187/202.0
VKRSLKSGETRTISHFHYTtWPDFGVPeSPASFLNFLFKVREsgSLNPDHGpAVIHCSAGIGRSgtfSLVDTCLVLMEkGDDINIKQVLLNMRKYRM-GL
|.| |.  ..  ..  ||   .| .|| ..|| |..| ..|   .|.  .. ...||  |.|||   ||| .||.|.   | |. |. . ..|. .  . 
vrrlldlyqqaglivhhyp.iadglvp.diasclkileelri..nlkayrk.tlvhcygglgrs...slviaclllyl.ddtiepkdaidklrdlkgsra

IQTPDQLRF
|||  |  .
iqtvkqyny
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 31-77 1.2e-07 25.5 In-house 36-87 (440) alignment 
Range on Protein: 31-77
Range on HMM: 36-87/440.0
DYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQN----AENDYINASLVD-IE
  |  .| .|.|. .||||..  |||||| |..     ..|||||| .. ||
sqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 65-144 1.5e-07 25.9 In-house 45-133 (290) alignment 
Range on Protein: 65-144
Range on HMM: 45-133/290.0
ENDYINASLVDIEEAQRsYILTQGPLPNT-------CCHFWLMVWQQKTKAVVMLNRIVEKESV----KCAQYWPTDDQ-EMLFKetGFSVK
 .||| |. | . . .|  |||| |. ..         .|| |. | | | ||||    ||..      ||.| |.    |. ||  |..||
nddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk..gltvk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-137 8.5e-07 22.6 In-house 236-289 (440) alignment 
Range on Protein: 81-137
Range on HMM: 236-289/440.0
RSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKesvKCAQYWPTDDQEMLFK
 ..| || ||  |   || .| . .  ...|||.. .|    |. ||| . . . | 
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 41-88 1.3e-06 22.5 In-house 47-95 (95) alignment 
Range on Protein: 41-88
Range on HMM: 47-95/95.0
ENRNRNRYRDVSPYDHSRVKLQN-AENDYINASLVDIEEAQRSYILTQG
 |  .||. .. ||| .|| |    . ||||| .||    .  || .||
anipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPDC1_pd Subfamily PTPDC1 198-290 2.1e-06 22.3 In-house 85-167 (182) alignment 
Range on Protein: 198-290
Range on HMM: 85-167/182.0
FHYTTWPDFGVPeSPASFLNfLFKVRESGsLnpDHGPAVIHCSAGIGRSGTfsLVDTCLVLMEkgdDINIKQVLLNMRKYRMGLIQTPDQLRF
..  .|.|.||. |  . |. . || ..  |  ..|   .|| || || |   |. . || ..   ... .. .  .|. |   ||| .|...
vynfgwkDygva.sleriLd.ivkvvafa.l..qegkvavhChaGlGrtGv..liacylvyak...rltaekaiklvrskrpksiqtreqvel
IKKbetaNEMObind I-kappa-kinase-beta NEMO binding domain 353-370 2.1e-06 14.1 Pfam-A 12-29 (38) alignment 
Range on Protein: 353-370
Range on HMM: 12-29/38.0
CTGLSSKMQDTMEENSES
.. |.| .|.||.| ..|
lsqLesvlqetmkEQdqS
Synaptobrevin Synaptobrevin 359-432 3.8e-06 13.9 Pfam-A 14-87 (89) alignment 
Range on Protein: 359-432
Range on HMM: 14-87/89.0
KMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLF
. .|.|.|| ...| .  . |   . ... |.. |  ... || ||  .|. .  .. .. |.|.  .. . ..
evkdimkeNidkvlergekldeLvdkteaLqesaqqFkkqarklkrkmwwknmklliililvvlililiiiivi