Gene PTPN12 in Homo sapiens

Synonym: PTP-PEST, PTPG1, tcag7.1075, PTPN12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP072_AA protein Get Run
HsapP072_AA_10-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 21-303 1.1e-142 469.2 In-house 3-287 (290) alignment
Range on Protein: 21-303
Range on HMM: 3-287/290.0
DHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
...||..||..|..|..||.||..||.|.|..|||||||||||||||||.|.|||.|. .. ...||||||||||||.|...|.|.||||..|. |||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKY
|||.|| |.||||||.|.|.|||||||| .||....|..|....|.|.| . |..|||| .|.|.|||..||||| .||||.||||..|.|..|.|.|..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

QEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ-LYEI
||.||.|...|||||.||||.|.||||...||||.|||||..||.|..|.|.||...||||||||||..|.|.|..|.|. ..| 
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieek

0051299 (Phosphotyrosine protein) phosphatases II 9-293 4e-95 313.8 In-house 9-285 (288) alignment
Range on Protein: 9-293
Range on HMM: 9-285/288.0
KFIQRVQAMKspdHNGEDNFARDFMRLRRLSTKyrtekiYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQG
.....|....   .||  .... | .|..| ..      ... .. ..||..||||.||||.|||||||.   .. .||||||..|.| . .....||||
ellklvlkll...angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqg

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDV
|| ||| |||||.||.|| .||| ....|.||.||..||||  ....|. .... . .|.   || .||| ..      ...|||. ..||| |||||.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|.|....||.. |.||.... . |...|||||.||||...|.|. ...|...   ....|..... .|.||. .||| |||..|..|.. .
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0050432 (Phosphotyrosine protein) phosphatases II 22-298 1.1e-94 312.5 In-house 38-303 (308) alignment
Range on Protein: 22-298
Range on HMM: 38-303/308.0
HNGEDNFARDFMRLRRLSTkyrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktpSQDSDYINANFIKGV--YGPKAYVATQGPLANTVIDFWR
 ..  .. . |..|... .      .... .....||..|||||||||.|||||||     ...||||||....|   . |....|||||| ||| ||||
aldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MIWEYNVVIIVMACREFEMGRKKCERYWPLYGE-DPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
|.||.|| .||| ....|.||.||..||||  . ..... .|.. . .|. . || .||| |..   .|||....||| |||||.||.|....||.. |.
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RKYQehEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
||..  .. ||..|||||.||||...|.|. ...|...    ...||.... .|.||. .|||.|||....||.. .... |
rksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0046845 (Phosphotyrosine protein) phosphatases II 28-298 2.2e-94 311.3 In-house 2-278 (284) alignment
Range on Protein: 28-298
Range on HMM: 2-278/284.0
FARDFMRLRRLSTKYRtekiYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKGV-----YGPKAYVATQGPLANTVIDFWRMI
. ..|..|..| .|.     ... .. ..||..|||||||||.|||||||.   .. .|||||||....|      | .|...|||||| ||| |||||.
leeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYgEDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
||.|| .||| ....|.||.||..||||. ....|. .|.. . .|. . || .||| |..    .|||....||| .||||.||.|....|... |.|.
weqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

YQE--HEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
..|  . . ||..|||||.||||...|.|. ...|...... ...|..... .|.||. .||| |||..|..|.. .. . |
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

0040438 (Phosphotyrosine protein) phosphatases II 25-302 4.9e-94 310.4 In-house 10-284 (317) alignment
Range on Protein: 25-302
Range on HMM: 10-284/317.0
EDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEY
.| ...||..|..   .... |.... ..|..|| .||||.||||.|||||||.  ..  |||||||....| . .....|||||| ||| |||||.||.
ldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

NVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH
.| .||| ....|.||.||..||||  ....|. .|.. . .|.   .. .||| .|    .|||....||| .||||.||.|.|..||.....|...|.
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYE
.. |...|||||.||||...|... ...|. ..   ...|.. ..|.| ||. |||| |||. ...|..... . |.| .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep

0036941 (Phosphotyrosine protein) phosphatases II 42-300 4.5e-93 307.1 In-house 23-283 (297) alignment
Range on Protein: 42-300
Range on HMM: 23-283/297.0
YRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRK
..  ..... .....||..|||||||||.||.||||    ....||||||....| . .....|||||| ||| |||||.||.|| .||| ....|.||.
lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

KCERYWPLYGEDPITFAPFKISCEDEQA--RTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGC
||..||||. ....|. .|.. . ...    .|| .||| ...   .|||....||| .||||.||.|..|.||.| |.||....  .. |...|||||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
||.|...|.|. ...|. ... ............|.||. |||| |||. ...|...|. |.|. 
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk

0045450 (Phosphotyrosine protein) phosphatases II 13-295 9e-91 300.1 In-house 14-305 (307) alignment
Range on Protein: 13-295
Range on HMM: 14-305/307.0
RVQAMKSPDHNGEDNFARDFMRLRRLSTKYrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFI--------KGVYGPKAY
 .....    ..   ... | .|... ...    .... .....|| .|||||||||.||.||||.  ..| .|||||||...        .| . ....
llllvllllldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

VATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgEDPITFAPFKISCEDEQARTDYFIRTLLLE---FQNESRRLYQFHYVNWPDH
.|||||| .|| |||||.||..| .||| ....|.||.|| .|||.  ....|. .|.. . .|.   .| .||| ..   . .|||....||| .||||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

DVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.||.||...||.| ..||..|.  .. |...|||||.||||...|... . .|..... . ..... ....| ||. |||. |||. ...|...|. 
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

0047943 (Phosphotyrosine protein) phosphatases II 22-292 3.3e-90 297.5 In-house 8-270 (273) alignment
Range on Protein: 22-292
Range on HMM: 8-270/273.0
HNGEDNFARDFMRLRRLSTkyrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMI
 .| . ... | .|..| .      .... .....|| .|||||||||.|||||||    ....||||||....| . .....|||||| ||| |||||.
llgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGED-PITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
||.|| .||| ....|.||.||..|||| |.. ..|. .|.. . .|. . || .||| |..   .|||  ..||| .||||.||.|..|.|..| |.||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

YQEH--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
..|.  .. |...|||||.||||...|.|. ...|...    ...|..... .|.||. .||| |||.....|.. 
alealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealle

DSPc_SM00195 39-294 1.3e-89 295.4 In-house 10-262 (263) alignment
Range on Protein: 39-294
Range on HMM: 10-262/263.0
STKYRTEkiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM
 ... ..   .| ..||..|..|||||.|||.||.||||. .  ...|||||||.|||   .|.|.|||||| .|| |||||.|| .| |||| ..|.| 
eestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGC
|..||.||||   ... ||  ... . ... .  .. .||| |....  |.|...|..| |||||.||.| .|.|.... ..| ......||..|||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||||....||. .. |...|    ...|....|.|.||...|||.|||  ...||....
gRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 39-294 1.3e-89 295.4 In-house 10-262 (263) alignment
Range on Protein: 39-294
Range on HMM: 10-262/263.0
STKYRTEkiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM
 ... ..   .| ..||..|..|||||.|||.||.||||. .  ...|||||||.|||   .|.|.|||||| .|| |||||.|| .| |||| ..|.| 
eestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGC
|..||.||||   ... ||  ... . ... .  .. .||| |....  |.|...|..| |||||.||.| .|.|.... ..| ......||..|||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||||....||. .. |...|    ...|....|.|.||...|||.|||  ...||....
gRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRD_pd Subfamily PTPRD 44-328 1.8e-89 295.9 In-house 34-315 (564) alignment
Range on Protein: 44-328
Range on HMM: 34-315/564.0
TEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
...  .. . .|..| .||||..|...|||||.|.     ..||||||.||.|   .|||.|||||||.|. |||||.||.|. .|||  .  |.|..||
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

ERYWPLYgEdPITFAPFKISCEDEQARTDYFIRTLLL--EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAI
..|||   . . |.  .... |.|.  .|| |||. |  . ..|||   |||...||||.|| |  |.||.|. .|...|..  || .||||| ||||. 
hkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtf

CAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPE
..||. .. .|.    .  .... ....|.||   |||.|||  .|.||..  ... .  |..  ..  . ..|..... .. .| |
ividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtglele

0043336 (Phosphotyrosine protein) phosphatases II 19-293 6.9e-87 286.7 In-house 13-276 (278) alignment
Range on Protein: 19-293
Range on HMM: 13-276/278.0
SPDHNGEDNFARDFMRLrrlstkyRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFW
 .  |.   . ..| .|       .. |.... .....||..|||||||||.|||||||.| .   |||||||....|   |....|||||| .|| |||
elllnlktllllefeel.......lsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMIWEYNVVIIVMACREFEMGRKKCERYWPlygEDPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
||.||..| .||| ....|.||.|| .|||   ....|. .|.. . .|.   || .||| ..    .|||  ...||..||||.||.|....||..  .
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

RKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|...|... |...|||||.||||...|... ...|. ..   ...... ..|.|.||..|||| .||. ...|....
realedsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley

0039614 (Phosphotyrosine protein) phosphatases II 25-297 1.5e-86 285.8 In-house 31-292 (297) alignment
Range on Protein: 25-297
Range on HMM: 31-292/297.0
EDNFARDFMRLRRLSTkyrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIW
   . ..|..| .|          .. .....||..|||||||||.|||||||. .  .  |||||||....| .  .....|||||| .|| |||||.|
ktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EYNVVIIVMACREFEMGRkKCERYWPLYGEdpiTFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH
|..| .||| ....|.|| ||..|||  |.   |. .|.. . ... . .|..||| ..  .||| ...|.|..||||.||.|....|... |.|.....
eqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
  .. |...|||||.||||...|... ...|. .    ...|.. ..|.| ||. |||| .||. ...|...|. . 
lpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrk

Y_phosphatase Protein-tyrosine phosphatase 58-291 1.3e-82 272.1 Pfam-A 1-234 (235) alignment
Range on Protein: 58-291
Range on HMM: 1-234/235.0
NVKKNRYKDILPFDHSRVKLtlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF
| ||||||||||.|..||||  |  ...|||||||..||   .|...|||||| .|. |||||.|...| .||| ... |.||.||..|||   |.. |.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

APFKISCE-DEQ-ARTDYFIRTLLLEFQNES---RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK
  .|. .. .|. . ..| .|.| |. ..|.   |...|.|| |||||.||.| .|.||.|  ..|..|... |...|||||.|||| ..|.|. .. |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
|..    ..|.....|.|.||...||. |||. ...||.
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 58-291 1.3e-82 272.1 In-house 1-234 (235) alignment
Range on Protein: 58-291
Range on HMM: 1-234/235.0
NVKKNRYKDILPFDHSRVKLtlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF
| ||||||||||.|..||||  |  ...|||||||..||   .|...|||||| .|. |||||.|...| .||| ... |.||.||..|||   |.. |.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

APFKISCE-DEQ-ARTDYFIRTLLLEFQNES---RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK
  .|. .. .|. . ..| .|.| |. ..|.   |...|.|| |||||.||.| .|.||.|  ..|..|... |...|||||.|||| ..|.|. .. |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
|..    ..|.....|.|.||...||. |||. ...||.
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0040439 (Phosphotyrosine protein) phosphatases II 49-294 6.9e-82 270.0 In-house 2-246 (249) alignment
Range on Protein: 49-294
Range on HMM: 2-246/249.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP
.. .....||..||||.||||.|||||||.      .||||||..|.| | .....|||||| .|| |||||.||... .|||.....|.||.||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LygEDPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAI
|  ......  |.. . ...   || .||| |.    .|||. ....|..||||.||.||...||.| ..||..|.  .. |...|||||.||||...|.
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
.. ...|.      ...... ....|.||. |||. |||. ...|...|.
ylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRB_pd Subfamily PTPRB 8-297 5.3e-81 266.9 In-house 10-288 (293) alignment
Range on Protein: 8-297
Range on HMM: 10-288/293.0
RKFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKYrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQ
.|| . |. ||.   . . .|. .. .|. . ..        ... |...| .||||..|||.|||||||.  . ...|||||||.|.|   |. ..|||
ekfeehvkkmka...dsdlrfseeyeelkavgkdq......avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD
||| .|| |||||.|| .. ||||  . .| |..|||.|||   |.|...   |..   |.  .|. ||.|..| ..|.|.. |.|.. ||||.||.. .
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk

SILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
..||..  .|...  .... || .||||| ||||.  |.|   .||.| .  .  ..| ...|.|..| . |||..||  .|... .|..|.
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald...rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 8-296 3.5e-80 264.4 In-house 5-282 (318) alignment
Range on Protein: 8-296
Range on HMM: 5-282/318.0
RKFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKYRTEKiyptaTgEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQ
... ..|. ...   .|| .. ... || | . .  . |     .  .. | .|||| .||..||.||||. .. ...|||||||.| |    |||.|.|
edleshvrrlre...sGelllseeyerlsrseetvtslk.....s.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSS
.||..|. |||||.|| |  .|||  .| | |..|..||||  .......   ..  ..|   .|| .|.. .. .  .|||   |.|| .|||..||.|
aPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

FDSILDMISLMRKYQ-EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
  |.||..   .|.| ...  || .||||| ||||  .|.|   . .|| ..    .||. ....|.||   |||..|||... .. .  . 
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealas

0042113 (Phosphotyrosine protein) phosphatases II 53-295 8.4e-80 263.0 In-house 4-244 (245) alignment
Range on Protein: 53-295
Range on HMM: 4-244/245.0
GEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygE
....||..||||.||||.||.||||.   .. |||||||....| . .. . ||||||..|| |||||.||... .||| ..|.|.||.||..||||  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

DPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-HEDVPICIHCSAGCGRTGAICAIDYTWN
...|.  |.. . .|.   || .||| ..    .|||  ...||..||||.||.. ...||.....||... ... |...|||||.||||...|... ..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

LLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.|.. .   ...... ..|.| ||. |||| .||. ...|...|..
qlekel...gvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_PTPN6_pd Subfamily PTPN6 12-300 1.1e-79 262.6 In-house 11-303 (306) alignment
Range on Protein: 12-300
Range on HMM: 11-303/306.0
QRVQAM-KSPDHNGEDNFARDFMRLRRLStkyrTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlKTPSQDSDYINANFIKGVY--GPKAYVATQG
|||. . |. .. .  .|  .| .|..      ..| .    |.| || .||||| ||||||.||.|. .   ..|||||||.||.      |.|.||||
qrvselekeeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPItFAPFKISCEDEQARTDYFIRTLLL---EFQNESRRLYQFHYVNWPDHDVPSS
 | .|| |||||.|. |  .|||. .| | |..|| ||||   |..  .   .... .|.. .|| .|.|..   ....|.|...|.|. .||||.||..
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

FDSILDMISLMRKYQEHE----DVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
 . .||... ... ||.       ||..||||| ||||..  ||   .|..  ..  .... .|.. .|.||   |||..|| .|..||..  |.. .|
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl

0045098 (Phosphotyrosine protein) phosphatases II 50-295 1.2e-78 259.6 In-house 25-273 (278) alignment
Range on Protein: 50-295
Range on HMM: 25-273/278.0
TATGEKEENVKKNRYKDILPFDHSRVKltlktpsqdsDYINANFIKGVygPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPl
  .. ...|..|||||||||.||||||          |||||..|.|   ||...|||||| .|| |||||.||... .|||.....|.||.||..||| 
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.

YgEDPITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDVPSSF--DSILDMISLMRKYQEH-------------EDVPIC
  ....|. .|.. ...|.   || .||||..        .||| ....||..||||.|||.   .|.|...  .|.....             .. |. 
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

IHCSAGCGRTGAICAIDYTWNLLkagkiPEEFNVFNLIQEMRTQRHS-AVQTKEQYELVHRAIAQLFE
.|||||.||||...|...   ||     .. ..... ..|.|.||.  |||..|||. .......|..
VHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0037934 (Phosphotyrosine protein) phosphatases II 53-294 3.6e-76 251.2 In-house 5-242 (243) alignment
Range on Protein: 53-294
Range on HMM: 5-242/243.0
GEKEENVKKNRYKDILPFDHSRVKLtlktpsQDSDYINANFIKGVygPKaYVATQGPLANTVID----FWRMIWEYNVVIIVMACREFEMGRKKCERYWP
. ..||..||||.||||.|||||||      ..|||||||.|...  |. . |||||| .|| |    ||||.||... .||| ....|.||.||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

lygeDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKY--------QEHEDVPICIHCSAGCGR
    ...|. .|.. . .|.   || .||||||    ....|  ...||..||||.||.|....||... .|..        ..... |...|||||.||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGAICAIDYTWNLLkagkipeEFNVFNLIQEMRTQRHS-AVQTKEQYELVHRAIAQLF
||...|...   ||       ...... ....|.||.  |||| .||. ...|...|.
tGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 9-295 9.9e-76 249.8 In-house 9-284 (319) alignment
Range on Protein: 9-295
Range on HMM: 9-284/319.0
KFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKyrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQG
.. .|..|..|   .||  ....|. |.  ...        . . .|||| |||||..||..|..||.|.    ...||||||.|| |    ....|||.
eLkerlkalas...tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqa

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSS
||.||. |||||.||... |.|| ..  | .. |...|||   |.. ..  . .  |.|.   || || | |. ..   |.|.. .|.| .||||||| .
PlentiedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

FDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
  |.||..  .|| .|. .. || .||||| ||||. ...| . . .|   .    .||. ....||||   ||..|||.... |. .  |
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 17-298 1.6e-74 245.5 In-house 6-280 (281) alignment
Range on Protein: 17-298
Range on HMM: 6-280/281.0
MKSPDHNGEDNFARDFMRLRRLSTKYrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVID
.|. ..| .  |....  |. . ..       ..   ...|||.||||..|  .|..|||.| .  ....|||||||..|. |.|.|.|||||. ... .
lkqlsqndnaGfieeyeklaaigvdn......tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEYNVVIIVMACREFEMGRKKCERYWPlYGEDPITFAPFKISCEDEQARTDYFIRTLLL-EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISL
||.|.||..| .|||  || | |. || ||||  ..  .... .... . |.... |  |.. | . ..|.|.. |..|..|||| ||..   .|.  . 
fWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrke

MRKYQEHED-VPICIHCSAGCGRTGAICAIDYTWNLLKagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
..|..|..  .|..|||||| ||||.  |.|   . ..  .  || .| ....|.| .|   |||  ||| |..|. . ..|.|
vlkltekktkaplvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-293 6.9e-74 243.8 In-house 9-289 (298) alignment
Range on Protein: 6-293
Range on HMM: 9-289/298.0
ILRKFIQRVQAMKSpdHNGEDNFARDFMRLRRLSTKYRTEKiypTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVA
.|.. .|...|.|   ...  ..| .| ||.. | . ..|.   .  ..|.|| ||||| ||...|.||| |. .   ..|||||| |...  | .|..|
dlkaalqklaavkk..kkkltgyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafia

TQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDpiTFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVP
||.|| .|| |||||..|...  |||     |... |...|||  |..  |.  ...|   ..  .|. .|.| .. .  ...|.. |.|...|||..||
tqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

SSFDSILDMISLMRKYQEHED-VPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
.   |.||... .|..|..   .|. ..|||| ||.|. .|||    .|   |. .   ||. .. .|..|  ||||.|||  .. |. . 
enatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid...svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 11-296 3.8e-73 241.0 In-house 6-281 (288) alignment
Range on Protein: 11-296
Range on HMM: 6-281/288.0
IQRVQAMKSPDHNGEDNFARDFMRLrrlstkYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPL
|. |.  .  . .....| ...  |         ||   . .|.. .| |||||..|||.|. ||||.     ...|||||..|.|  . |.|.||||||
ispvakvakksarnrtgfseeynsL......aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl

ANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSIL
|.|| |||....|...  |||     | |..|||.|||  ...|  .  ...   ...  .|.  |.|||| ... ... |..|  ||||.|| |   .|
adtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapll

DMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
.... .   .. .  || .||||| ||||   |.|   . ...    .  .|.. ....| || . |||..||| .......| |.
ellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_Ptp69D_pd Subfamily Ptp69D 15-295 7.3e-72 237.1 In-house 11-287 (307) alignment
Range on Protein: 15-295
Range on HMM: 11-287/307.0
QAMKSPDHNGEDNFARDFMRLRRLstkyrtEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTV
.|.|| ... .  .|... .| .       |    | ..||.||  ||||.|| .||. ||||.  . ..|||||||.||||    | ..| |.|. .|.
ealksrkrdtdfglakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveati

IDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgeDPITFAPFKISCEDEQARTDYFIRTLLLEFQN-------ESRRLYQFHYVNWPDHDVPSSFD
 ||||||.| .| .|||   . |. ||||..|||    | . .    . . .|.  .|| ||.| .  ..       .||.. |.|| .|.|  || .  
gDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

SILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
..|..|. .|. ....  || .||||| ||.| . |.|  .. |||    .. ..|. ....| ||   ||  |||. ..||...  .
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkae...dkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 49-294 8.5e-72 236.9 In-house 37-283 (305) alignment
Range on Protein: 49-294
Range on HMM: 37-283/305.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP
..  |.||.|..|||.|.| ..|..|..|| |   .|||||||....|  . |.|...|||| ||| ||||.|.|. |. ||| ..  | |..||..|||
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

LYGEDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAI
    ..  | .|..  ..|.. .||..| | . .   ..||| . |..  .|||| || .  |.|..|  ..| |... .||. .||||| ||||. .|.
esktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiav

DYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|   . ||.    |. .||......|..|  .|||..||  .| |...| 
dialerlkkE...evvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_PTPN3_pd Subfamily PTPN3 38-297 2.3e-71 235.0 In-house 21-278 (280) alignment
Range on Protein: 38-297
Range on HMM: 21-278/280.0
LSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIK----GVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMAC
  . || ..   . .  | ||..||||.||||.|. ||||.    ....||||||...    .    . |.|||||||.|. |||.|.|| .. .|||  
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

REFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHC
   | ||.|| .|||   || .... |.. || |.... | .| |.|. ..  |.|.. |. |..||||.||.. ...|.... .||... .. |. .||
tlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
||| |||| . ... .  |. |    |.... .....|| || . |||..||..|  || ...|..
saGigrtGvlilletalaliea...aepvypldivrtmrdqramlvqtasqykfvCeailkvyeei

subfamily_PTPN13_pd Subfamily PTPN13 49-294 1.7e-70 232.4 In-house 28-269 (273) alignment
Range on Protein: 49-294
Range on HMM: 28-269/273.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPsqdsdYINANFIKGVYGPKA--YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERY
 . .|.|.|| .||||...||.|..||||  ...     ||||..||   | .   |.|.|||| .|| |||.|.|| .. .|.|   | | |. ||.||
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPLYGEDPITFAP-FKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhEDVPICIHCSAGCGRTGAICA
||   .....    .... .. | . .. .|.| .. .  .|||.. ....|.||||.|||| ...| ... .|. |. .  || .||||| ||.|.. .
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

IDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||   .|..  |   ||.| ......| ||.. ||||.|| .|..|| ...
idvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPN9_pd Subfamily PTPN9 54-292 5.6e-70 230.7 In-house 38-288 (297) alignment
Range on Protein: 54-292
Range on HMM: 38-288/297.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED
..  |..||||.|.| .|..||.|. .   . ||||||||. |   .||..|||||| .|| |||||.|| .|..|||. |  |.|| || .||||  |.
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

PITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-------------HEDVPICIHCSAGCGRT
 . |. ...|  . . . || .|.| ..   ..|||..  | .. |||. ||||  |.||... .|..|               .. || .||||| |||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|. ...|.. . |.     .  .|.. .. .||||  ..|| ||||. . |. .
Gtfitldiclsrleev...gtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_PTPRA_pd Subfamily PTPRA 52-294 1.1e-69 229.8 In-house 52-295 (330) alignment
Range on Protein: 52-294
Range on HMM: 52-295/330.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYG
. .|||| .|||. .|||.|.||| |. |   ..|||||| ||.|    . ..|.|||...|| ||||||||..   |||     |  ..||..|||  |
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

EdpITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
   .|.   ... |||.   || .| .|..       ...|| . |||.  |||  ||.    .|...  ..| .. .  || .||||| ||||. ...|
l..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

YTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
   . .|| ..    .||. ....|.||   |||.||||...... . .
avlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 58-297 1.5e-69 229.1 In-house 28-270 (274) alignment
Range on Protein: 58-297
Range on HMM: 28-270/274.0
NVKKNRYKDILPFDHSRVKLTLKTPSQD-SDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED--
. .|||||.||| ..||| |. ...... |.|||||.|||  .  ||||||||||.||| ||||||.. .| .|||  .  |. ..||..|.|   .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

PITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDV---PICIHCSAGCGRTGAICAIDYTWNL
  ..  ..|  |.   | || .|.|.|. ....|... . | .||||..| . ...||..  ... .|.|.    |. .||||| ||||.  ||. . . 
serygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

LKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQlFEKQ
|..    .  .|.... ..| .|   |||.|||||.|||... ..|.
lre...eivvdvlkivcnlrldrGGmvqtseqyelihralcl.ylkr

subfamily_PTPRG_pd Subfamily PTPRG 10-294 2.3e-69 229.1 In-house 6-287 (563) alignment
Range on Protein: 10-294
Range on HMM: 6-287/563.0
FIQRVQAMKSpdhNGEDNFARDFMrlrRLSTKYRTEKiYPTATGEKEENVKKNRYKDILPFDHSRVKLTlKTPSQDS--DYINANFIKGVYGPKAYVATQ
| . | ....   .|.  |...|     | ..  ...  .. . .|.|| .|||| .|...|.|||||. ..| ...  ||||||.|.| .  ||..|||
fakhvaslha...dgdigfseefe...alqsetiskd.ldaehsqkpenkrKnRylnivaydrsRvkls.plpgkkkklDYinAnyidGyqkskafiatq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEF-------Q-NESRRLYQFHYVNWPD
|||..|. |||||||| || ||||     | ||.||..|||   ....|.  ...  ..|.  . | .||| ..        | .. .. .|.|| .|||
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|.||..    | ..    . ...|  || .||||| ||||  ...|    |||  .  .  |||.... .|.||   |||.|||  .| |. .. 
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld...tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 46-293 7.6e-69 227.0 In-house 37-278 (315) alignment
Range on Protein: 46-293
Range on HMM: 37-278/315.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
...|  .  | ||..|||| .|...|.|||.| |    ..|||.|||||.|   .. |.|.|||....| ||||...|...  |||     |  ..|.|.
qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWPlygEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
|||   .. ... .. ..  .|.  |.| .|||   |... | ..|.||  ||| .|| .  .....|  ...... .  .| .||||| ||||. ...|
ywp...dkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld

YTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
   . ..|    .  .|.|.|. .| .|  .||. |||.... |. . 
avldqaea...enaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_PTPRK_pd Subfamily PTPRK 52-291 1.4e-67 222.7 In-house 37-274 (314) alignment
Range on Protein: 52-291
Range on HMM: 37-274/314.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlyg
.  |.|| .|||..|||..|.|||.|.     ..||||||..| .   |.|...||||| .|| ||||.....|   |||     | || || .|||   
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...

EDPITFAPFKISCEDEQARTDYFIRTLLLEF----QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYT
||  .. ..|. . . .. ... .|.. .|     |.| | . ||....||||||| |  ..|...  . | ||.|. .| .|||||.||||. .|||  
edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

WNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
 ....  ..    .||| ....|...   |.|.||| ... .| 
ldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvil

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 52-293 1.2e-66 219.5 In-house 3-241 (250) alignment
Range on Protein: 52-293
Range on HMM: 3-241/250.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKkCERYWPLyg
 ..| .| .|||| ||...|.||| |  .   ..|||||| |..|  . ||..|||||| .|. |||||..|...  |||     |.... ...|||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..

EDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRR--LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTW
| . ..   ..|  ...  .|| .|.| |  .... .  . |.|.|.|||  ||    ..|.... ... |.. .. |. ..|||| ||.|| .|||   
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NLLkagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
. |   |. .  .||..|. .|..|  ||...|||  |...| . 
erl...kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 54-296 1.3e-65 216.1 In-house 16-266 (270) alignment
Range on Protein: 54-296
Range on HMM: 16-266/270.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGE
|   . | |||.||||  ..||.|   .  . . |||||...|. | .|.|.|..|||..|. .||||||| .|  |||.    | ||||||||||   .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DPITFAPFKISCED-EQARTDYFI-RTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD------SILDMISLMRKYQEHEDV--PICIHCSAGCGRTGAIC
. ....  ||.    ...... .| . | || . |.|||  |.|..|||| ||.. |      ..| |.  .|..... |   |. .||||| |||| . 
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

AIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
|.|.. .||.  |   . .| ..|.|.| .|   ||. ||||....|...  |.
alDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 46-310 2.5e-65 215.4 In-house 32-294 (315) alignment
Range on Protein: 46-310
Range on HMM: 32-294/315.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
.||.. .. ...| ||||||.|||.|..|||| .   | ||||||| .||.|   |||.|.||||  .| |||||.....|  |||     |  . || .
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
|||    | . |  .|..  . .| ||  .| | .   .|||.. ||.. .|||. |.    |.| .|  ..  ..... .. .||||| |||| ...||
ywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

YTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE-KQLQLYEIHGAQKIA
   . .| .   .  .|||.....|..|   |||.|.| ... |. . .  ..  .  || .... 
evvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 45-293 3.8e-65 214.9 In-house 30-275 (515) alignment
Range on Protein: 45-293
Range on HMM: 30-275/515.0
EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCE
 .||| .  ..| | ||||||.|||.| .|||| .   . .|||.|| .|...   |||.|.|||.  .| ||||.....||  |.|  .  |  . || 
pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

RYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAI
.|||    | . |  .|..    .| |.  .|.| .  ...|| . |||. .|||. ||    |.| .|  ..  ...   |. |||||| |||| ...|
kyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

DYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|      | ..     .|||... .| .|   |||.||| ... |. . 
dsvvahakttr...mvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 43-292 8.4e-63 207.2 In-house 36-282 (297) alignment
Range on Protein: 43-292
Range on HMM: 36-282/297.0
RTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGpkAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREfEMGRKK
 . .|.|. . ||  | .|.|||.|||.| |||||     . ||||.|| |.||.     ...|| |  .|| |||.|.....| .|||   . . . ||
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkk

CERYWPLYGEDPitFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPS--SFDSILDMISLMRK-YQEHEDVPICIHCSAGCGR
| |||.  |  .  |    .  .  . |. .  |.| .. ..    | . |...|.|||..|.   |  |.|..|| .|| ...... |. .||.|| ||
caryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

TGAICAIDYTWNllkAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|| ...||         |  .| ..|.|.. .| .|   |||||||..|. |. .
tgvlltidsvva...eakrekevdifglvkklrqerpylvqtkeqykfvyvavle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-293 5.7e-60 198.3 In-house 57-292 (319) alignment
Range on Protein: 54-293
Range on HMM: 57-292/319.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgRKKCERYWPLYGEd
. ..|  |||. .||.||...|||      . |||||| |..|   .. |.|.|||| ||. ||||||||||.  ||.        ..|| .|||| .. 
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.

pITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDYTW
 |.   ||.. .  .   .| .| . |     ... |.. |||.  |||. || .   .. ..  .|. .  |..  .| .|||||.||||.  ..|   
.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

NLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ--L
. .|  |     .|.|.....| ||   ||   || ... |. .  |
drmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_PTPN23_pd Subfamily PTPN23 23-298 1.3e-59 196.4 In-house 12-284 (288) alignment
Range on Protein: 23-298
Range on HMM: 12-284/288.0
NGEDNFARDFMRLRRLSTKYrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVY-GPKAYVATQGPLANTVIDFWRMI
.|. .. . |  |..   |        ...   . ...|||..||||.||.||||     ..  ||||| |.|..  |   ..|||.||..|. |||.|.
dgktaldkkfkeleqkqdke....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNE--SRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK-
.|  . .|||   . |.|..|..||||   ... .| ..........    .  |.| ||....   . .   .. .||.. ||.| ...|...  ... 
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesa

YQE---HEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
|..   . ..|. .||||| ||||... .    . |..|..    .. .... .|.||.  ||.|||.. .  |. .  .. |
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 19-295 2.1e-59 195.8 In-house 13-284 (290) alignment
Range on Protein: 19-295
Range on HMM: 13-284/290.0
SPDHNGEDNFARDFMRLRRlstkyrTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQD--SDYINANFIKGVYGPKAYVATQGPLANTVID
    .|.. |  .|..|        .|. . . .|  ..| ..||...|.. |  |. |  ..  .|   .|||| .|||    |.|.|||||. ||..|
nghakgnegfrnqfkmlds......gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPitFAPFKISCEDEQARTDYFIRTLLLEFQNE---SRRLYQFHYVNWPDHDVPSSFDSILDMI
||..||. .| |||| . . |.|..||  |||  . .   . .|.|   .|.. ..| .|.| .. .|.   .. . |..  ||....      .|| .|
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

SLMRKYQE-HEDVPICIHCSAGCGRTGAICAIDYTWNllkAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
. | | |  . . .| .|||.. ||..  ||.. | |     |.    .||......|.|.   |||..||..... . . ..
eemyktqrkrgntsivvHCSdtvgrsavfcaaattin...kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 56-293 3.2e-59 195.8 In-house 23-256 (284) alignment
Range on Protein: 56-293
Range on HMM: 23-256/284.0
EENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgRKKCERYWPLYGEdpI
..|  |||. .||.||...|||      . |||||| ||.|   .. |.|||||| ||. ||||||||||.  ||.        ..|| .|||| ..  |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv..i

TFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDYTWNL
.   ||.. .  .   .| .| . |     ... |.. |||.  |||. || .   .. ..  .|. .  |..  .| .|||||.||||.  ..|   . 
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ--L
.|  |     .|.|.....| || . ||   || ... |. .  |
mkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_PTPRN_pd Subfamily PTPRN 41-294 3.8e-59 194.8 In-house 40-292 (297) alignment
Range on Protein: 41-294
Range on HMM: 40-292/297.0
KYRTEKIYpTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMG
.|..|.   ......|.||||||.|..||.|||||||. .. ...|||||| .|        ||.|||||||.|| |||.|.||  ||.||. .|  | |
ayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg

RKKCERYWPLYGEDpiTFAPFKISCEDEQA-RTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCG
 |.|.||||  |..  ..  ...    |     ||..|.. |    ..|.| . |||.. ||...||.|  |.|..   . |       || .|||.|.|
vkqckrywpdeGse..vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|||. ..||   | |. |    | ..   .. .| ||.  |.||.|.|..  |.|.  
rtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 21-292 2.6e-58 192.3 In-house 15-276 (287) alignment
Range on Protein: 21-292
Range on HMM: 15-276/287.0
DHNGEDNFARDFMRLRRLSTKyrTEKIyptATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
 ..|...|   |. | ... .   ...     .  ..| .|||...||. |  || |      .. ||||| ||.|    ||......|..||. .||..
hakgnegfknqftvleqvtqr..edev...thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

IWEYNVVIIVMACREFEMGRKKCERYWPLYGEdpITFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHD-VPSSFDSILDMISLM
|.. || .||| |.| |  ...| .|||      ... ...|.  .|.  ..| .|.| .. .|   . ... |... ||...  |..   ..| .   .
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy

RKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
.. . . . .| .|||.. ||..  ||.. | |  |        .||......| |.  .||| |||. .  .. .
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckt...eGviDvfqvlksqriqkpgsvqtveqykfindivle

subfamily_PTPN1_pd Subfamily PTPN1 45-292 1.5e-57 189.5 In-house 18-269 (290) alignment
Range on Protein: 45-292
Range on HMM: 18-269/290.0
E-KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
| . .||.. ...|| ..|||.|. |.||||.||     ..| |||||....     . |. |||||.|||  ||.|.|| .   .||  .  | .. ||
easdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

ERYWPLYGE-DPITFA--PFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCG
 .|||   | . ...    .|.    |. .  | .|.| ||    .|.| ...|||. |||  ||.|  . |...  .|.     ..  |  |||||| |
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|.|..| .|    |... .  .  .. . . |.| .|.  .||..| .. . || .
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN14_pd Subfamily PTPN14 50-294 4.9e-55 181.6 In-house 41-296 (300) alignment
Range on Protein: 50-294
Range on HMM: 41-296/300.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYW
. |.. .||..|||.||.||....||.|.    . ...||||  || . | |   |...|||| .|| |||.|.|| .| .|||  .| | |..|. .|.
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PLYG--EDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSS---FDSILDMI-SLMRKYQEHE-----DVPICIHCSAG
|  .  .. ..|  ||.. .  .  . .  ..| |..   .| | .. . |..||||.||.    | | |... |. || ...      . |. .|||||
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

CGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
 |||| .   |   . |. .   || .. . .. .|.|| . |||  ||. |.... . .
vGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

0041856 (Phosphotyrosine protein) phosphatases II 58-296 1.1e-52 173.6 In-house 1-173 (182) alignment
Range on Protein: 58-296
Range on HMM: 1-173/182.0
NVKKNRYKDILPFDHSRvkltlktpsqDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgrkkCERYWPlygedpitf
|..||||.||||.||||          |.||||||.. | . .. ..|||||| .|| ||.||..|... .||...         .|.|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

apfkiscedeqartdyfirtlllefQNESRRLYQFHYVNWPDHDVPSsFDSILDMISLMRKyqehEDVPICIHCSAGCGRTGAICAIDYTWNLlkagkip
                         ... |  .|..|..||||.||. .|..||.|  ...    |. |. .|||||.||||...|... . |       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

eEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
 ...... ....| .|. .|.| .|| ....|. .|.. 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 53-294 1.3e-51 170.7 In-house 43-288 (325) alignment
Range on Protein: 53-294
Range on HMM: 43-288/325.0
GEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMaCREFEMGRKKCERYWPLYGE
  | ||..|||.|.....|.||| |  |  . .||||||....   . . ..|.| ||..|. |.||.. ...  ..|.   |.. | ..|  |||    
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemg

DPITFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE------HEDVPICIHCSAGCGRTGAICAI
.  || .....    .  .||  | | .   .  |.| . ||..  |.|  |.    ... .. |. . .|      .   || .||||| ||||.  ..
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

dYTwnLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
 |.  .|.      . ..|. .. .| .| | |.| .|| |.. |... .
.ys..alakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 49-291 2.5e-51 169.3 In-house 24-264 (283) alignment
Range on Protein: 49-291
Range on HMM: 24-264/283.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPsqdsDYINANFIK---GVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
..     .|| .|||...|.| |  ||.|  ...    ||||| ||         | |...|.|| .||.|||.|... ... |||  .  |  |.|| .
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPLYGEdpITFAPFKISCEDEQARTDYFIRTLLLEFQ---NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAIC
|||  |   . . .| .. ..| .   . |. |||  .   ...  |  . ...| . .  .  .|.. .  .. . .|... || .|||.| |||.. .
yWPkrGs..edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

AIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI-A
|.  . . ...  .    .||. .. || ||  ||||..|| ||| ..  
aasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 54-303 4.7e-51 168.3 In-house 34-286 (287) alignment
Range on Protein: 54-303
Range on HMM: 34-286/287.0
EKEENVKKNRYKDILPFDHSRVkLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgED
|.  .|||||| |.||.|..|| |  ... . |||||||.. .    .|..|.|||.| || ||||...| ..  ...  || | .|.|| .|||   | 
eelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev

PITFAPFKISCEDEQ-ARTDYFIRTLLLE-FQ-NESRRLYQFHYVNWPDHDVPSS----FDSILDM---ISLMRKyqEHEDVPICIHCSAGCGRTGAICA
|.    . .   | .    .| .|.| |   . .|.| . |.....|||. .. .       .||.   | | |.    |  |. .|...| ||.| . |
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard..asevGPlvvhddvGiGrsGilla

idyTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEI
   |. |.. ..   . .| . .  .| .| . ||.  |. |.  |..  .. . ||| .
...tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqlyva

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 45-292 9.1e-51 167.5 In-house 32-234 (392) alignment
Range on Protein: 45-292
Range on HMM: 32-234/392.0
EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGrkkce
 .|||.....|| |.||||||.|||.| .|||| .   . ||||.|| .|...   |||.|.||| | .. |||||... ||  |.|  .  |       
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

rywplygedpitfapfkiscedeqartdyfirtllleFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAI
                                       .. |   |||...|||.|||    |.| .|  ..    .   |. |||||| |||| . .|
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|      |  ..    .|||.. ..| .|   ||||||| ... |. .
dsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 24-292 6.4e-50 164.4 In-house 25-281 (290) alignment
Range on Protein: 24-292
Range on HMM: 25-281/290.0
GEDNFARDFMRLR-R-LSTKYRTEKIYptatgEKEENVKKNRYKDILPFDHSRVKLTlktPSQDSDYINANFIKGVYGPkaYVATQGPLANTVIDFWRMI
. |..|....      | ..|   ||.     .|. ..|||||||.   | .|| |      .| ||. ||..||.  .  .. |||.|..||||.|||.
nvdelakeyleklkpylpvqylerkif.....dkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ---NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
 . .|  ||| |  .| |. |||.|.|    . .||  . . |  |. . .  |. .|   .     . .|. .. . |||. |. |  ..| ..  .||
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk

YQehedVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
       |. .||||| ||||.. ||. . ..|  ||   |... .|.. .|  | ..||   || .. ... .
as....GpvvvhcsaGiGrtGtfvaievglqilldGk...eldlldlvralrnsrlnsvqvdiqylalveilld

0051429 (Phosphotyrosine protein) phosphatases II 86-297 8e-50 165.3 In-house 4-228 (272) alignment
Range on Protein: 86-297
Range on HMM: 4-228/272.0
SDYINANFIKGVYG---PKAYVATQGPLANTVIDFWRMiWEYNVVIIVMACREFEMGRKKCERYWP----------LYGEDPITFAPFKISCEDEQARTD
|.||||....| ..   |... ...||| .|. ||||. .|...  ||. ..|.|.|| ||.||||           ... .|..  . . .  |.  .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YFIRTLLLE---FQNESRRLYQFHYVNWPDHDVPSSFdsILDMISLMRKyqeheDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFN-----VFN
| .|.|||.     .|.|.....|| .|||| ||..   .|....|...     . |. .|||||..||| ..|...    . .  | ...      ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

LIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
 ..|.| ||. |||| |||. ...|...|... 
aveelraqrpgavqteeqylflyeallellrsl

0049772 (Phosphotyrosine protein) phosphatases II 31-305 2e-49 164.3 In-house 21-291 (314) alignment
Range on Protein: 31-305
Range on HMM: 21-291/314.0
DFMRLRRLSTKYRTEKIypTATGEKEENVKKNRYKDILPFDhSRVKLtLKTPSQDSDYINANFIKGVygpKAYVATQGPLANTVIDF----------WRM
 ...| |.|  . .|..  . .. ...| .||||.||||.| .||.|  . | ..||||||....|.   ....|||||| .||.||          |||
lllvlnrrslsvlpelt..ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

I--WEYNVVIIVM---------------------ACREFEMGRKKCERYWPLYGedpitfapfkisceDEQARTDYFirtlllefqneSRRLYQFHYVNW
.  ...|| .|||                      ..  . |   ......|.               .|.   ..|           .|. ........
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..............eelydpelf...........erlgikylripv

PDHDVPsSFDSILDMISLMRKYqeHEDVPICIHCSAGCGRTGAICAIDYtwnLLKAGKipeeFNVFNLIQEMRTQRH-----SAVQTKEQYELVHRAIAQ
||...| ... ..... .....  ... |. .||.||.||||  ....|   |.|. .    ...   ....| .|.     ..... |||| ...|. .
pDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaay...lmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealle

LFEKQLQLYEIHG
....... ||.  
ylkflkkfyeyle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 55-294 5.5e-49 161.8 In-house 38-277 (307) alignment
Range on Protein: 55-294
Range on HMM: 38-277/307.0
KEENVKKNRYKDILPFDHSRVklTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
 . | .||||.|.   |..|.   .|..   |||| ||..     || ....|||| ||. .|| |. . .|  ..| |.  |... |||.||||   . 
fsantdknryqdvkcqdkgri..vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

ITF--APFKISCEDEQ----ARTDYFI--RTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRkyqeHEDVPICIHCSAGCGRTGAICAIDY
 .|  ||  || ..      |  . .|   || ... ..|| . .. . ||||. ||    . ..... .|     .  |. .||||| ||.|.| || .
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaisl

TWNLLKAGKIPEEFNvfNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
  . . ||.   . .  .|..|.|.||| |.||. ||  .|| . . |
vqdkmiaGinckdmk..klveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 55-290 9.7e-49 160.7 In-house 4-236 (239) alignment
Range on Protein: 55-290
Range on HMM: 4-236/239.0
KEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlygED
|  |  |||| .|. .||||| |   .    ||||||....   | ||||.|||| .. .  |||||.|.   ..|||     |  .||| .|||   . 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...ds

PITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNLL
   .. ....    .  .|| |||...    | | | .||.|.  |||. ||    ..| .   . |       |  |||||| |||||.  ||    .|
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...aml

KAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
.  |  .  ..|| .. .| .|   ||| ||| ..| |.
rqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 54-290 9.8e-49 160.7 In-house 4-237 (239) alignment
Range on Protein: 54-290
Range on HMM: 4-237/239.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlygE
.|  |  |||| .|. .||||| |   .    ||||||....   | ||||.|||| .. .  |||||.|.   ..|||     |  .||| .|||   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...d

DPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNL
    .. ....    .  .|| |||...    | | | .||.|.  |||. ||    ..| .   . |       |  |||||| |||||.  ||    .
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...am

LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
|.  |  .  ..|| .. .| .|   ||| ||| ..| |.
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 57-290 1e-48 160.7 In-house 2-235 (237) alignment
Range on Protein: 57-290
Range on HMM: 2-235/237.0
ENVKKNRYKDILPFDHSRVklTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPI
||  |||| .|  .|||||   || .  .||||||...||. | || |.|.|||| ..  |||.|.|. .  .|||     |  ..|| .|||   ..| 
enkiknrygnivaydhsrv..vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpa

TFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAIDYtwnL
..  . .|   ... .|| .|.|||  .    | | ..|...  |||. ||    ..| .   . .  .|  |  |  |||||| |||| .  ||    .
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida...m

LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
|.  |  .  ...| .. .  .|   .|||.|| ..|..|
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_CG7180_pd Subfamily CG7180 50-288 5e-47 155.0 In-house 34-284 (296) alignment
Range on Protein: 50-288
Range on HMM: 34-284/296.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRkKCERYWPL
 |.| ..|| .|||. ...|.|. || |.     ..|||||| .. .   .|.|. |..|  .|| .|||.... ..  .|. ...|.. . ..  ||| 
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

YGedPITFAPFKISCEDEQARTDYFIRTLLLEFQ------------NESRRLYQFHYVNWPD-HDVPSSFDSILDMISLMRKYQEHE-----DVPICIHC
 .     . .. .    |.  ..  |||. |  .             | | . .|..  |.  . ||.|  ......  .|...|.        |.....
ks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGCGRTGAICAIDYTWNLLKagkIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHR
| | .|.|. .||| . .|..   . ||..||. .. .| .|   |...|.|  .  
sdGasRsGvylaidanlelve...keeevdvFeavktlrrsRpqLvenveeYkyiYd

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 46-294 2.5e-46 152.8 In-house 28-293 (301) alignment
Range on Protein: 46-294
Range on HMM: 28-293/301.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTP--SQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
.  ..  | .||| . ||.|.| ..|. |. |. |.   ..  .||||..|.|.   |...|.|||. .|..||||.||.. .| ||| . . |  ..||
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

ERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN-----------------ESRRLYQFHYVNWPDHDVPSSFDSILDMIS-LMRKYQEHEDV
|.|||   ..  .| ||..   .||.  |. || | .  |.                 .|. . |.. ..||.. |      .|  |   . . |  .  
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg

PICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|. .|||.. .|.|  |... .    ||  .    .||.... .| ..  ||.| |||  .. .| . .
pvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_ptpA1_pd Subfamily ptpA1 50-243 3.2e-46 152.9 In-house 39-248 (418) alignment
Range on Protein: 50-243
Range on HMM: 39-248/418.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYgPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP-
|. |.|. |  |||| .||| .|.||.|      . |||||||.| | | || ...||||| ||. |||||.||  . ||||  || |  | ||.|||| 
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

--------LYGEDPITFAPFKISCED--EQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ------EHEDVPICIHCS
        .||.    |  . .   .  ..   .   | . | |. |.| . |..|  ||||..|   . . ...  . . |         .||| .|||
qiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGCGRTGAICA
|| ||||..|.
agvgrtgtfct

0036282 (Phosphotyrosine protein) phosphatases II 86-287 1.4e-45 150.5 In-house 2-163 (174) alignment
Range on Protein: 86-287
Range on HMM: 2-163/174.0
SDYINANFIKGVYGPKAYVATQGPLAntvidFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygedpitfapfkiscedeqartdyfirtlllEFQNE
||||||......| .. ..|.|||||     ||.|..|... ..|| ..|.|.|. || .|||                                  . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRRLYQFHYVNWPDHDVPSSFDsILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTWNLLKagkiPEEFNVFNLIQEMRTQRHSAVQTKEQYE
.|  .|..|..|||| ||..   .|............ .. |. .|||||.||||...|...   .|.    .   ....|..|.|.||. .||| .||.
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyr

LVH
 ..
fly

0043147 (Phosphotyrosine protein) phosphatases II 84-287 2.5e-45 149.6 In-house 3-154 (172) alignment
Range on Protein: 84-287
Range on HMM: 3-154/172.0
QDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREfemgrkkcerywplygedpitfapfkiscedeqartdyfirtlLLEFQ
..||||||......| |. ..|||||| ||. |||||..|... .||.....                                           |.  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

NESRRLYQFHYVNWPDHDVPsSFDSILDMISLMRK-YQEHEDVPICIHCSAGCGRTGAICAIDYTWnllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQ
...|  .|..|..||||.|| ... .|........ ... .. |...|||||.||||...|... .         . ..... ....|..|  |||...|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YELVH
| ...
yrfly

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 22-291 2.9e-45 149.5 In-house 16-276 (439) alignment
Range on Protein: 22-291
Range on HMM: 16-276/439.0
HNGEDNFARDFMRLRRLSTKYRTEKiyptATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMI
.| .. |   |  .   | .|. .     .   .| .  ||||||. .|||.|| |        | |||||.||| | .| |.|||||  .|. ||||..
knkqeifkeifekinstspdyacia....slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlv

WEYNVVIIVMACREFEMGRkkcerYWPlyGEDPITFAPFKISCEDEQARTDYFIRTLLLE----FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
.| ..| ||| .  .|  .     |||   .. . .    . .. .    .| || . .       .  | . ||||. |||..||.    .||..  . 
iekktvtivmltnlvesyk.....ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain

KY-QEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
   ...|  |. .||||| ||||.| |.| . . ||.    .. ..  ... .| ||.  ||.  || ... |. 
sandkeeygpvvvhcsagvGrtGtiialdialeqlkl...enkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 55-298 3.6e-45 149.0 In-house 45-291 (305) alignment
Range on Protein: 55-298
Range on HMM: 45-291/305.0
KEENVKKNRYKDILPFDHSRVKLtlkTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
. .. .||||||.  .|. ||||    ..   .|| ||..     || .. || || .|  ||| | .. .|  | | |   | | |||  |..   .| 
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

ITFA--PFKISCEDEQARTDYFIR---------TLLLEFQ-NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQehedVPICIHCSAGCGRTGAIC
..|     |||   | . |  | .          |..|   ...|.  ..|...|||  ||..  .||...   |  .     || .||||| ||||.. 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsvv

AIDYTWNLLKAGKIPEEFNvfNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
 ..|  . | ||.| |. .   ..| .| ||  ..|| .|| .||. | . |.|. 
mleyildqllagqiiedtd..kilqkireqrnnsiqtdaqylfvhqvilnyfrkkk

0046846 (Phosphotyrosine protein) phosphatases II 80-295 6.1e-45 148.4 In-house 6-174 (176) alignment
Range on Protein: 80-295
Range on HMM: 6-174/176.0
KTPSQDSDYINANFIKGVYgpkaYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPItfapfkiscedeqartdyfirtll
 ..  |.||||||.| | .    ..|||||| .|. ||..|..|... ..|. . |.|.|| || .|||.. .  |                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lefqnesrrlyQFHYVNWPDHDVPSSfDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDytwnLLKAgkiPEEFNVFNLIQEMRTQRH-SAVQ
           |.....||||.||.. . .|... ..|.....   |. .|||||.||||...|..    ||.       ..|.. ....| ||.  |||
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreqRplgavq

TKEQYELVHRAIAQLFE
| |||. ..... .|..
tpeQyrflyefellllk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 56-291 4.2e-44 145.3 In-house 35-266 (281) alignment
Range on Protein: 56-291
Range on HMM: 35-266/281.0
EENVKKNRYKDILPFDHSRVKLTLKTPSQDS-DYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
  | ||||| .|  .| |||.| .| | ..| ||| ||.|.  .  . |. ||||  .|  |||||||. |   ||| |.  |  |.||  |.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

ITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSildMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDYTWNLLKAG
. |  . .| ||           | | .. |.| . .. . .||| .|| | .    |. ..|| . .   |  |||||| ||.|.. |.. . . ... 
lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev...mlkilrkirars.tppvihcsagvgrsgtlmaveialqsihsh

K-IPEefnVFNLIQEMR-TQRHSAVQTKEQYELVHRAIA
  .|.   . ...  .| | | ..||| .|| |. . . 
ftlpd...ikqivshlrvtgraasvqtlqqymliwkvll

0049260 (Phosphotyrosine protein) phosphatases II 93-287 1e-42 140.7 In-house 1-143 (152) alignment
Range on Protein: 93-287
Range on HMM: 1-143/152.0
FIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWplygedpitfapfkiscedeqartdyfirtlllefqnesrrlyQF
||.|.. |....|||||. ||. |||||..|... .||| ....|.|. |||.|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWnllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVH
....|||| ||.. . .|... ...|...... |. .|||||.||||...|... .           ..... .. .|..|  ||....|.....
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 54-290 1.8e-42 140.2 In-house 29-291 (297) alignment
Range on Protein: 54-290
Range on HMM: 29-291/297.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPsqDSDYINANFIKGVYG--PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYG
 ..  ..||||.||| .| .||||    .  ..|||||...       .  |. .|||| .|| |||....| .| .||| ..  | ||.||  |||   
krnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

EDPITFAPFKI----SCEDEqaRTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD--------------------SILDMISLMRK-----Y--Q
..  . . . .    |  ||      ..  | | ...||| .    ...|||| ||| ..                    ....|.. |       .  .
qerlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae

EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefnVFNLIQEMRTQRHSAVQTKEQYELVHRAI
   .... .||||| ||.| .   |   . |. ..||.   |  ... .| ||   ||| ||.||.. |.
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripd...vaailsilreqrarlvqtleqfellydav

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 24-295 2.3e-41 136.4 In-house 22-290 (305) alignment
Range on Protein: 24-295
Range on HMM: 22-290/305.0
GEDNFARDFMRLRRLSTKYRTEKIYpTATGEKEENVKKNRYKDILPFDHSRVKLTlkTPSqDSDYINANFIKGVYGP-KAYVATQGPLANTVIDFWRMIW
| |..  .| .| . .    |....  |    . .. ||||.|.   |.| |||    ||  |||| ||..     | | ....|||| .|. .|| |. 
gvdklreefrglakytrpdmtqvaf.nanqsadiaitknryqdvpcqdqsavkld..kps.psdyihanyvgcpmipekrficaqgpldqtidefwwmvi

EYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAP----FKISCEDEQAR-TDYFIRTLLLEF-QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
. .|  ||| |.  |.|. || .|||.   .  ..       ..|      | ..  | .| | .  ...  . .... .|||  ||    . |...| .
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai

RKYQehedVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
|  .    ||| .||||| ||||.| ||.|  . .   |      . .|.. .| ||  ..|.  ||  .|| . . | 
rgsk....vpivvhcsagigrtgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 25-299 1.5e-39 130.7 In-house 5-264 (267) alignment
Range on Protein: 25-299
Range on HMM: 5-264/267.0
EDNFARDFMRLRRLSTKYRTekIyptATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqdsdYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEY
| .. ..|  ....|..  |  |   ..   |.| ..||. | ||.|..|| |  |.      |||| ...| .  .|...||.|| ||. ||. .| ..
eceiekefelikkisdtsst..i...sqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdq

NVVIIVMACREFEmgrKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLY-QFHYVNWPDHDVPSSFDSILDMIsLMRKYQEHE
.| .||.  . |.    .  ..||    .   .  . .    |.   || | || |.|.||| .    ..| .|        .   |  | | ..  |  
kvpvivlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgi.laknqleng

DVPICIHCSAGCGRTGAICAIDYTwnlLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
. |. ..||.| ||.|.   ||     |.  |  .  ..|......| || . |.|||.|  .|. .|.  | .|.
nrPlvvacsdGvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk

0051082 (Phosphotyrosine protein) phosphatases II 86-290 1.4e-35 117.4 In-house 3-149 (151) alignment
Range on Protein: 86-290
Range on HMM: 3-149/151.0
SDYINANFIKGVygpkaYVATQGPLAntviDFWRMIWEYNVVIIVMACREFEMGrkKCERYWPLYGedpitfapfkiscedeqartdyfirtlllefqne
|||||.... |      . ...||||    ||.....|...  ||. . |.|.|  .| .|.| .|                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqeHEDVPICIHCSAGCGRTGAICAIDYTWnlLKagkipeeFNVFNLIQEMRTQRHSAVQTKEQYEL
 ..........|||...| |||..|....|...   ... |. .|||||.||||...|..     |.       ....  ..|.| .|. .||...|. .
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqflf

VHRAI
...|.
qlfal

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 58-292 1.5e-35 117.7 In-house 43-269 (288) alignment
Range on Protein: 58-292
Range on HMM: 43-269/288.0
NVKKNRYKDILPFDHSRVKLTlktpsQDSD-YINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPIT
|  ..||...   | .||||.      |.| ||.|| .     ..  . .| ||  |.  .|.|. | .|  ||| |.  | |..| . |.|.   . . 
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FAPFKISCEDEQARTDYFIRTLLLEFQNESRR---LYQFHYVNWPDHDVPSSFDSILDMISLMrkyqEHEDVPICIHCSAGCGRTGAICAIDYtwnLLKA
.  .     ...|  |  ..  ||  ..|      . . |. .|.|. || .. | | ..  .    .  . || .|.||| ||||..  |      |..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlilili...ales

GKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
 ....   . .|....| .|  |.||. ||  ||| . .
lrlddflgirsllaklreerfkaiqtemqylyvhrcvle

0044763 (Phosphotyrosine protein) phosphatases II 69-295 1.6e-35 117.7 In-house 1-172 (178) alignment
Range on Protein: 69-295
Range on HMM: 1-172/178.0
PFDHSRVKLTLKTPSQDSDYINANFIKgvygPKAYVATQGPlantvIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEdpitfapfkiscedeq
|.|..||.|.     . ||||||..|     |  |.....|      |......|...  ||. . |.|.|. || .|||   .                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

artdyfirtlllefqnesrrlYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLlkagkipeEFNVFNLIQE
                     .|......|||.||.... .|... ....... .. |. .||||| ||.|...|... . |         ..... |..
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRTQRHsAVQTKEQYELVHRAIAQLFE
.| .|  .|.. .|.. ...   .|..
vrerRp.ivpnpgqlrqLyefelrllk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 56-290 2.1e-35 116.8 In-house 50-286 (310) alignment
Range on Protein: 56-290
Range on HMM: 50-286/310.0
EENVKKNRYKDILPFDHSRVKLTLKTpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDpI
.....|||| |..  | |||||..   |.  ||| ||..|  |  .... .||||  |.|||||||..     |.. |.  | || ||  |||  |    
kkymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt.e

TFAPFKISCEDEQArTDYFIRTLLLEFQ------------NESRRLYQFHYVNWPDHDVPSSFDSILDmislMRKYQEHEDVPICIHCSAGCGRTGAICA
|.   ...   | .  .. |  | . |              .  |.   .. ||||  ||      .      |   .    |  .||||| .|.....|
tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvva

IDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
...... |. |.   . .. ... |.. .|   .||. || ...|  
lklkidkldrgl...kvdaeevktellksraiciqtelqyliidrvr

PTPc_DSPc_SM00012 189-291 1.7e-33 110.3 In-house 2-104 (105) alignment
Range on Protein: 189-291
Range on HMM: 2-104/105.0
LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHED--VPICIHCSAGCGRTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELV
....|| .|||| ||.. ||||...  ..| .....   |...|||||.|||| ..|.|. .. |....  .|...|....|.|.||...|||.|||  .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

HRAIA
.||..
yrall

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 89-283 2.4e-33 110.2 In-house 78-270 (301) alignment
Range on Protein: 89-283
Range on HMM: 78-270/301.0
INANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQART--DYFIRTLLLEF---Q
| ||.|.    |. ..|||||| ||  ||| |.  |.|  ||| ... |   .||| | |.  .. .    |||  ....     .   ||| .|    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhedvPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQY
 ..| .  . |..|.|..|| |   . |.. |..| ..    || .||||| ||. |  . .|  . ..| .   . .. . ....| .| ..|||..| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadp...tieltealkhlrehrwngvqtnsql





subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 55-289 8.8e-33 108.5 In-house 32-265 (285) alignment
Range on Protein: 55-289
Range on HMM: 32-265/285.0
KEENVKKNRYKDILPFDHSRVKLtlKtpSQDSDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED
 | |   ||| |.   . .|| |  |   .| ||| |....       .|..||||| .|. |||.||.. ..  ..| |  || | .||  |.|    .
yeanpdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PITFAPFKIS---CEDEQ-ARTDYFIRTLLLEFQNESRRLYQFHY--VNWPDHDVPSSFDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDYT
 . |  ..|.   |..|  | | .   |..   .  |  ||  |     |||.  |     ....   ..| . .|  |||.||||| ||| ..  |||.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidya

WnlLKAGKIPeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA
   ..  . | . .......|||. |  |||.. |. ...  
t..irimenp.niemldivremramrfqavqshmqflflyvv

subfamily_egg_pd Subfamily egg 43-296 3.9e-32 106.2 In-house 25-272 (307) alignment
Range on Protein: 43-296
Range on HMM: 25-272/307.0
RTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMgrKK
 . .  .  |  ...| .| | | .   | ||||| |.      |.| || .||      .. .| || ||| |||||... .|  |||     |   ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CERYWPLYGEDPITF--APFKISCEDEQARTDYFIRTLLLEFQNESR-RLYQFHYvNWpDHDVPSSFDSILdmiSLMRKYQEHeDVPICIHCSAGCGRTG
|| |||   .|.. .    ..| . . . ..| . |   |      .  ..  |. .. | .  |   | |    ..|| ..    |. ...  |. ...
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehw.qg.dvnnssdvyspl...rvlrklrnl.skpvvvqdilGvskaa

AICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
.. ||. .   |  | |   . | . .. .| .|. .|..  .| .|.| .. .|  
tlvaieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_CG42327_pd Subfamily CG42327 60-213 1.6e-28 94.3 In-house 30-187 (319) alignment
Range on Protein: 60-213
Range on HMM: 30-187/319.0
KKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVY-GPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLY--GEDPIT
.|.|. ...|. ..|| |  ..  . . |..|....|    |  |.|.| .| ..  ||||..|| .  .|| ..  .| | |.| .|.|    ...  .
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYvNWPDHDVPSSFDSILDMI
.  ....  . ...  |.| ||||    ..||| |  . | .|.. .||..  ... |.
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-298 2.2e-27 90.6 In-house 46-281 (312) alignment
Range on Protein: 61-298
Range on HMM: 46-281/312.0
KNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPL-----YGEDPI
 ||| .|  .|  |  |.     ..  || |||.| .  |. .|.||||| ||.  ||..      . |.. |   | | .|| .|          ||  
lnrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

TFAPF----KISCEDEQARTDYFIRTLLLEFQNESrRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqehEDVPICIHCSAGCGRTGAICAIDytwNLL
 .. .    .|     .  |   .. ..    .|| .| .. .  |||| .| | |. | ..| ..|    .  |.  ||||| ||||... |.    ..
vyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalie...smi

KAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL-FEKQL
 | . |   || .    .| .|  .|..  ||  . |.. .. . | |
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

0048076 (Phosphotyrosine protein) phosphatases II 146-293 4.1e-27 90.0 In-house 2-142 (145) alignment
Range on Protein: 146-293
Range on HMM: 2-142/145.0
YWPLYGEDPITFAPFKISCEDEQA--RTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICA
|||    . . . ..   .. |.      . . .|  |.....|  .|..|..||||.||.... .|... .........  |. .|||||.||||...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
..  .         . ..... ....|.||. ||.. .|.. ..... .|
aylmll........lgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 58-153 1e-25 85.2 In-house 47-156 (350) alignment
Range on Protein: 58-153
Range on HMM: 47-156/350.0
NVKKNRYKDILPFDHSRVKLT--------LKTPSQDSDYINANFIKGV-----YGPKA-YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
   |||||.|||..||||||          |   . .||||||..|         |.  |.|||.|| .|| ||...| . .| .|..   ..|....||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ERYWPLYGED
.|||.  . |
yrYWqegsyd

0048179 (Phosphotyrosine protein) phosphatases II 173-288 2e-24 81.4 In-house 31-139 (144) alignment
Range on Protein: 173-288
Range on HMM: 31-139/144.0
YFIRTLLLEFQNESRRLY--QFHYVNWPDHDVPSSFDSILDMISLMRKYQEhEDVPICIHCSAGCGRTGAICAIDYTWnllkagkiPEEFNVFNLIQEMR
. . .|  |. .|.   .  |.....||||.||.... .|... ......| |. |. .|||||.||||...|..  .         . ..... ....|
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

TQRHSAVQTKEQYELVHR
..|  ||.. .|.. ...
srrpgavpnpgqlrfLle

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 70-302 2.5e-24 80.9 In-house 30-268 (290) alignment
Range on Protein: 70-302
Range on HMM: 30-268/290.0
FDHSRVKLTLKTPSQDSDYINANFIKGVYGpKAYVATQGPLANT-------VIDFWRMIWEYNVVIIVMACREFEMGRK----KCERYWPLYGEDPITFA
. ..|| |        .||| ||...   |  . ..|| |....       . .|| |. . .|  .|| |   |  ..     |..| | . .. ..| 
veatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

PFKISCEDEQARTDYFIRTLLLEFQNESRR-LYQFHYVNWPDHDVPSSFDSILDMISLMRkyqeHEDVPICIHCSAGCGRTGAICAIDYTWNLLKagKIP
 ....| .  .  |  .|.|...|..|    .    ...| .  |. .  ..|..|. ..     .. |. .||  |  |  |. ||.  . ..   .  
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkia..ets

EEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL-QLYE
..... ......| ||  |.......  |  .|  |. . | | .|
gsvkledvlkalrkqralaitsalelafvdagivllaievldqfae

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 109-285 6.2e-22 72.4 In-house 99-279 (302) alignment
Range on Protein: 109-285
Range on HMM: 99-279/302.0
PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFI-----RTLLLEFQNESRRL------YQFHYVNW
|  .|.  .| .| .||| |.|  |   | . |||  |.    .. ..|  . .   . .   . |      .   .|..|| ..         ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDVPSSFDSILDMISLMRKYQEHedvpICIHCSAGCGRTGAICAIDYTWNLLKAGKIPeefNVFNLIQEMRTQRHSAVQTKEQYEL
|||  |   .. ||..     |..     . .||||| ||||.. || |  .| .  |.    .. .... .|. |. |||...|   
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliy

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 57-292 7.5e-22 72.3 In-house 46-277 (303) alignment
Range on Protein: 57-292
Range on HMM: 46-277/303.0
ENVKKNRYKDILPFDHSRVKLTlktpsqDSDYINANFIKgVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPIT
.|..|||. |.. .|||.|||.      || || |.... .   |  . || ||. |  |||.|| | .|  ...   . |. .   .  .|   .| . 
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.nqdflk

FAPFKISCED-EQA--RTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSS-----FDSILDMISLMRKYQEHEdvPICIHCSAGCGRTGAICAIDYTW
|    |   .  .      . .. | .   .    |.  || .||  ..||         | .. |..||| . .  |      .||||.|... .. . 
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst..ptvymslsgcgragtfalfetah

NLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
  |.. .    ... . .. .|  |  |||   |. .|.  .|.
lslhseq..asldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 185-292 2.7e-21 70.4 In-house 87-192 (440) alignment
Range on Protein: 185-292
Range on HMM: 87-192/440.0
ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQY
||| | |.||  |||. ||     .| ||  . . ||.  . |. .|||||.|||| | |.|   ..|.  |  .. ..|..|. || .|   ||| |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavd...silreakrsdqidifsfinsmrnnrpqmvqtpeqy

ELVHRAIAQ
 .|| |. .
afvheavle

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 57-299 2.3e-19 64.0 In-house 50-290 (302) alignment
Range on Protein: 57-299
Range on HMM: 50-290/302.0
ENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTV---IDFWRMIWEYNVVIIVMACREFEMGRkKCERYWPLYGED
.|.|||. .|.   |. .|||.     .  .|.||  ..     .  . .| |  ...    .||||... ..| .|.. .| |. .   . ..|.  .|
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

PITFAPFKI-----SCEDEQArTDYFIRTLLLEFQNeSRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTW
  ..  . .     .  .|.. | | |  |  .. | |      .  ||... || .. ..   .  . . ... | .. |    |.|| ||. .   . 
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsn.svlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

NLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
. |..|   .| |. .... .|.|| .||.. .||  ...|.. .. |...
eklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkvt

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 105-282 4.5e-19 63.5 In-house 39-209 (255) alignment
Range on Protein: 105-282
Range on HMM: 39-209/255.0
AtqgplanTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDeqARTDYFIRTL--LLEFQ--NESRRLYQFHYVNWPDH
        ||  |...|   .   .|| |   | |..||..|.||  ..   .|  .... .  . .|  .|||  ....    . . .  ..|  |...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

DVPSSFDSILDMISLMRKYQehedvPICIHCSAGCGRTGAICAIDYTWN-LLKAGKIP--EEFNVFNLIQEMRTQRHSAVQTKEQ
  |     || .. ..|. .     .. .|||.| ||. |   ... .  .... .     |..  .|..|.| .|..|..|  |
naPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

subfamily_hpo-7_pd Subfamily hpo-7 100-280 1.1e-18 62.1 In-house 42-213 (263) alignment
Range on Protein: 100-280
Range on HMM: 42-213/263.0
PkayvatqgpLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQArtDYFIRTL--LLEFQ--NESRRLYQFHYV
          | .|.  |...|   .   .|| |   | |..||..|.||  ..   .|  .... . |   |  ..||  |  ..   . . . .. |.
l.........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysyk

NWPDHDVPSSFDSILDMISLMRKYQEhedvpICIHCSAGCGRTGAICAIDYTWN-LLKAGKIP--EEFNVFNLIQEMRTQRHSAVQTK
 |...  |  . .|| .. . |. ..     . .|||.| ||. |   ..  .  .... .     |..  .|..|.| .|..|..| 
gWiekndpelareilnilkvarnsks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP

subfamily_eak_pd Subfamily eak 45-207 4.7e-18 59.7 In-house 39-199 (332) alignment
Range on Protein: 45-207
Range on HMM: 39-199/332.0
EKIYPTATGEKEENVKKNrYKDILPFDHSRVKLTLKTpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCE
...     ... |.|..|   .|.|.|.  |.||         ||||  ..     . |. |  .  . |  ||.|. | .   ||.   . |.. .| .
qrllsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD
.|.|  . . . |  ... . .   |  .  | | |.  ||. |.. ...  | . ..|   |
kyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 99-286 6.3e-17 56.4 In-house 3-196 (199) alignment
Range on Protein: 99-286
Range on HMM: 3-196/199.0
GPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN----ESRRLYQFHY
| . |.||| || .|. |||.|.||     |||   .          |||        .. . ....   .. || | .|.|  .      .| . .. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VNWPDHDVPSSF---DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELV
  | ..  |        ..    . .||..  | |. .||| | | || . |.|      .  |     ..|.. . .|  |   . . ..|...
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 100-286 6.6e-17 56.3 In-house 3-195 (198) alignment
Range on Protein: 100-286
Range on HMM: 3-195/198.0
PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN----ESRRLYQFHYV
 . |.||| || .|. |||.|.||     |||   .          |||        .. . ....   .. || | .|.|  .      .| . .. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDHDVPSSF---DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELV
 | ..  |        ..    . .||..  | |. .||| | | || . |.|      .  |     ..|.. . .|  |   . . ..|...
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 58-147 2.2e-16 54.1 In-house 48-153 (349) alignment
Range on Protein: 58-147
Range on HMM: 48-153/349.0
NVKKNRYKDILPFDHSRVKLT--LKTPS------------QDSDYINANFIKG--VYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRK
   |||||||||..||||||   ||..             .  ||||||..|   .   | |.||| ||  || ||...|   .| ...    ..| . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCERYW
||..||
kcdiyw

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 188-299 1.6e-15 51.7 In-house 216-349 (350) alignment
Range on Protein: 188-299
Range on HMM: 216-349/350.0
RLYQFHYVNWPDH---DVPSSFDSILD-------MISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN-LLKAGKIPEEFN-----------VFNL
 .||... ||.|      | |. ..|.              ... .  || .|||||.|||| ....|.  . ..   .. .|..           .. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
..|.| || | ||...|.  .. |.  .|. ...
vnelrkqrismvqnldqfifiYeallfyfaLrkd

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 57-135 7.1e-14 46.0 In-house 95-172 (244) alignment
Range on Protein: 57-135
Range on HMM: 95-172/244.0
ENVKKNRYKDILPFDHSRVKLTlkTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMA-CRE
.|  |||    |||| .|| |.    |    |||| |.  .     |. || |||.| .|||.|. |  | ..|.    |
nnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 101-185 5e-13 43.2 In-house 236-316 (440) alignment
Range on Protein: 101-185
Range on HMM: 236-316/440.0
KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefEMGRKKCERYWPLYGEdPITFAPFKISCEDEQARTDYFIRTLLLEFQNE
.|..||| ||  ||.||||.. .|..  |.|     ..  | |  |||.     .|| || .     .      .||| | ...|
nafiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykee

subfamily_PTPDC1_pd Subfamily PTPDC1 191-293 9.5e-13 43.0 In-house 84-175 (182) alignment
Range on Protein: 191-293
Range on HMM: 84-175/182.0
QFHYVNWPDHDVPsSFDSILDMISLMRKYQEHEdvPICIHCSAGCGRTGAICAIDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
 .. . |.|..|. | ..|||.. ..    ...   . .|| || |||| . |    ..        ....  . |. .| .| ...||.|| |||.   
yvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvya........krltaekaiklvrskrpksiqtreqvelvkefa

AQL
. |
lfl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 182-295 1.1e-12 42.0 In-house 213-345 (349) alignment
Range on Protein: 182-295
Range on HMM: 213-345/349.0
FQNESRRLYQFHYVNWPDHDV---PSSF-------DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKA-----GKIPEEFNV----
 ...   |.|. . ||.|  .   | |.       . ..|       ... .  .. .|||||||||| .. .|.  ..|.       ||  .       
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

FNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.  . |.| || | ||   |.  .. |. . | 
siivnelrkqrismvqnlaqfiaiyealLkyfa

subfamily_CG42327_pd Subfamily CG42327 221-292 1.1e-12 42.3 In-house 244-313 (319) alignment
Range on Protein: 221-292
Range on HMM: 244-313/319.0
EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
...  |. .||| | |||| . | | . . |.  |  .  .. .|.. .| .| |||.||||||.... . .
resqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 49-108 5e-12 39.8 In-house 39-95 (95) alignment
Range on Protein: 49-108
Range on HMM: 39-95/95.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKtpsQDSDYINANFIKGVYGPKAYVATQG
| ..|  | |. |||. .|.|.| .|| || |   .||||||| |. |    ..|.|.||
pytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 52-131 3.6e-11 37.2 In-house 31-115 (347) alignment
Range on Protein: 52-131
Range on HMM: 31-115/347.0
TGEKEENVKKNRYKDILPFDHSRVKLTLK----TPSQDS-DYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVM
. | | ...||| ||    | .|| |. .    ....|.  ||||  ||     | |. || || .|| |||.|.   .|  .| 
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 68-198 3.8e-10 34.2 In-house 3-122 (130) alignment
Range on Protein: 68-198
Range on HMM: 3-122/130.0
LPFDHSRVKltlktpsqDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVM-ACREFEmgrkkcERYWPlyGEDPITFAPFKISCED
|.|. ||..        . .||||.|.  .   . |. || |||.| .|||.|. |  | ..|.    | |      . |||    .|. .   .|    
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywp..dsePlewyeediivtl

EQARTDYFIRTLLLEFQNESRR----LYQFHYVNWP
 .     .|..  || ...  .    |  |.  |||
tdrdefknikasnleiesdlneshqaltmfqisnwp

PTEN_1 175-285 3.5e-09 31.8 In-house 71-184 (196) alignment
Range on Protein: 175-285
Range on HMM: 71-184/196.0
IRTLLLEFQN---------ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAIdytwNLLKAGKipeeFNVFN
. .| .|. .         . .. .... . ..|| .||    .    |..  .....    . .|| || ||.| ..|      |...||    ... .
vvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk....ltade

LIQEMRTQR-HSAVQTKEQYEL
 .. .| .| . |... .| .|
AlelvrekRppgapnspsqerl

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 46-130 1.7e-08 28.3 In-house 22-105 (332) alignment
Range on Protein: 46-130
Range on HMM: 22-105/332.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTpsQDSDYINANFIKGVYGPKAYVATQGPLAN-TVIDFWRMIWEYNVVIIV
  || .  .  .|.  ||   .  ||||||.|. .      |. ||... |     ||. .| |. . |   ||||. | .  .|.
mtypntydkflnnmdmnriphlycfdhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmil

0038934 (Phosphotyrosine protein) phosphatases II 191-291 3.1e-08 29.0 In-house 81-174 (194) alignment
Range on Protein: 191-291
Range on HMM: 81-174/194.0
QFHYVNWPDHDVPSSFDSILDMISLMRKY-QEHEDVPICIHCSAGCGRTGAICAIDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA
...   .||. .. |.. .|. ..|. .. .|...  . .|| || |||| ..|                ...   |. .|  | .|... ...| ... 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdyleallkr

IA
  
yk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 229-292 3.3e-08 27.8 In-house 2-62 (69) alignment
Range on Protein: 229-292
Range on HMM: 2-62/69.0
IHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
.|||.| ||||.  ||      .|. |.    ..|| .| ||  |   |  ...| ..| |...
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 228-292 4.8e-08 27.3 In-house 2-63 (69) alignment
Range on Protein: 228-292
Range on HMM: 2-63/69.0
CIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
 .|||.| ||||.. ||      .|. |.    ..|| .| ||  |   |  . .| ..| |...
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_PTEN_pd Subfamily PTEN 173-285 5.4e-08 28.0 In-house 62-171 (184) alignment
Range on Protein: 173-285
Range on HMM: 62-171/184.0
YFIRTLLLEFQNESRRLY-QFHYVNWPDHDvPSSFDSILDMISLMRKYQEHEDV-PICIHCSAGCGRTGAICAIdYtwnLLKAGKIPEEFNVFNLIQEMR
| |  |  | . .|...  . . ..  ||  | ... . .... ..|. |...   . .|| || |||| . .  |   |||....... .. .| .|.|
ykiynlrserkydskkfdgrvavypfdDhn.ppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva.y...llkslllekaeealelfaeaR

TQRHSAVQTKEQYEL
|. ...|.   |   
tknkkgvtiPsqrRY

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 49-97 6.5e-08 26.3 In-house 38-86 (440) alignment
Range on Protein: 49-97
Range on HMM: 38-86/440.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGV
|.      .|  ||||..|| .||||| |       ||||||| .|.|.
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 178-287 3.8e-07 23.0 In-house 196-302 (346) alignment
Range on Protein: 178-287
Range on HMM: 196-302/346.0
LLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPeefNVFNLIQEMRTQRHSAV
.| | . .|      |.  |   . |     |. ||  .   .. ... .|.    ||||. ..    |. | |  |  |   |......... ||  .|
vlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiep...niceimknikqqrpggv

QTKEQYELVH
..  ||  ..
esfaqyasiy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 57-97 4e-07 23.9 In-house 38-77 (244) alignment
Range on Protein: 57-97
Range on HMM: 38-77/244.0
ENVKKNRYKDILPFDHSRVKLTLkTPSQDSDYINANFIKGV
 |. |||| .|||||..|| |.  .  . |||||||.|.| 
anatknryinilpfdetrvilss.skkegsdyinanyiqgs

subfamily_DSP23_pd Subfamily DSP23 192-288 4.9e-07 24.5 In-house 54-140 (148) alignment
Range on Protein: 192-288
Range on HMM: 54-140/148.0
FHYVNWPDHdVPSSFDSILDMISLMRKYQEHEDVpICIHCSAGCGRTGAICAIdYtwnLLKAGKIpeefNVFNLIQEMRTQRHSAVQTKEQYELVHR
.. .. .|.  | . . . ... .. . .|...  . .||  | ||||.. |  |   |.|  |.       . | |.| .|  .|.| || .||. 
lvrlriddy.hppaleqvvefvrvveeaeeknea.vsvhcllgrgrtgtmlac.y...lvkerkl....aaaeaiaevrrlrpgsvetveqeklvrd

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 54-131 2e-06 20.9 In-house 23-73 (169) alignment
Range on Protein: 54-131
Range on HMM: 23-73/169.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINAnfikgvygpkayvatqgplantvidfwRMIWEYNVVIIVM
|   |  |||    |   | ||||        ||||||                           ||||| |  .||.
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 54-131 2.4e-06 20.5 In-house 22-72 (169) alignment
Range on Protein: 54-131
Range on HMM: 22-72/169.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINAnfikgvygpkayvatqgplantvidfwRMIWEYNVVIIVM
|   |  |||    |   | ||||        ||||||                           ||||| |  .||.
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv

subfamily_eak_pd Subfamily eak 212-294 6.3e-06 19.8 In-house 223-305 (332) alignment
Range on Protein: 212-294
Range on HMM: 223-305/332.0
MISLMRKYQEHE--DVPIcIHCSAGCGRTGAICAIDYTWNLLKaGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
. |...||.       || | .. |  |.|.   ||   .|.  .|. . . | .||  ....|  .| .. |. ... .. . .
lsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl

subfamily_VSP_pd Subfamily VSP 192-294 7e-06 20.1 In-house 96-198 (212) alignment
Range on Protein: 192-294
Range on HMM: 96-198/212.0
FHYVNWPDHDVPSsFDSILDMISLMRKYQEHED-VPICIHCSAGCGRTGA-ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRa
 . ..  ||.||. .. .| .   .... |..    . |||  | ||||. .||.  . ....  |   ..      .. .....  |||  |.  |.  
vkriliddhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgy.

IAQLF
..|..
leqvk