Gene PTPN12 in Homo sapiens

Synonym: PTP-PEST, PTPG1, tcag7.1075, PTPN12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP072_AA protein Get Run
HsapP072_AA_10-295 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 21-303 1.1e-142 469.2 In-house 3-287 (290) alignment 
Range on Protein: 21-303
Range on HMM: 3-287/290.0
DHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
...||..||..|..|..||.||..||.|.|..|||||||||||||||||.|.|||.|. .. ...||||||||||||.|...|.|.||||..|. |||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKY
|||.|| |.||||||.|.|.|||||||| .||....|..|....|.|.| . |..|||| .|.|.|||..||||| .||||.||||..|.|..|.|.|..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

QEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ-LYEI
||.||.|...|||||.||||.|.||||...||||.|||||..||.|..|.|.||...||||||||||..|.|.|..|.|. ..| 
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieek
0051299 (Phosphotyrosine protein) phosphatases II 9-293 4e-95 313.8 In-house 9-285 (288) alignment 
Range on Protein: 9-293
Range on HMM: 9-285/288.0
KFIQRVQAMKspdHNGEDNFARDFMRLRRLSTKyrtekiYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQG
.....|....   .||  .... | .|..| ..      ... .. ..||..||||.||||.|||||||.   .. .||||||..|.| . .....||||
ellklvlkll...angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqg

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDV
|| ||| |||||.||.|| .||| ....|.||.||..||||  ....|. .... . .|.   || .||| ..      ...|||. ..||| |||||.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|.|....||.. |.||.... . |...|||||.||||...|.|. ...|...   ....|..... .|.||. .||| |||..|..|.. .
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 22-298 1.1e-94 312.5 In-house 38-303 (308) alignment 
Range on Protein: 22-298
Range on HMM: 38-303/308.0
HNGEDNFARDFMRLRRLSTkyrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktpSQDSDYINANFIKGV--YGPKAYVATQGPLANTVIDFWR
 ..  .. . |..|... .      .... .....||..|||||||||.|||||||     ...||||||....|   . |....|||||| ||| ||||
aldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MIWEYNVVIIVMACREFEMGRKKCERYWPLYGE-DPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
|.||.|| .||| ....|.||.||..||||  . ..... .|.. . .|. . || .||| |..   .|||....||| |||||.||.|....||.. |.
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RKYQehEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
||..  .. ||..|||||.||||...|.|. ...|...    ...||.... .|.||. .|||.|||....||.. .... |
rksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0046845 (Phosphotyrosine protein) phosphatases II 28-298 2.2e-94 311.3 In-house 2-278 (284) alignment 
Range on Protein: 28-298
Range on HMM: 2-278/284.0
FARDFMRLRRLSTKYRtekiYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKGV-----YGPKAYVATQGPLANTVIDFWRMI
. ..|..|..| .|.     ... .. ..||..|||||||||.|||||||.   .. .|||||||....|      | .|...|||||| ||| |||||.
leeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYgEDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
||.|| .||| ....|.||.||..||||. ....|. .|.. . .|. . || .||| |..    .|||....||| .||||.||.|....|... |.|.
weqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

YQE--HEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
..|  . . ||..|||||.||||...|.|. ...|...... ...|..... .|.||. .||| |||..|..|.. .. . |
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 25-302 4.9e-94 310.4 In-house 10-284 (317) alignment 
Range on Protein: 25-302
Range on HMM: 10-284/317.0
EDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEY
.| ...||..|..   .... |.... ..|..|| .||||.||||.|||||||.  ..  |||||||....| . .....|||||| ||| |||||.||.
ldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

NVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH
.| .||| ....|.||.||..||||  ....|. .|.. . .|.   .. .||| .|    .|||....||| .||||.||.|.|..||.....|...|.
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYE
.. |...|||||.||||...|... ...|. ..   ...|.. ..|.| ||. |||| |||. ...|..... . |.| .
pggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
0036941 (Phosphotyrosine protein) phosphatases II 42-300 4.5e-93 307.1 In-house 23-283 (297) alignment 
Range on Protein: 42-300
Range on HMM: 23-283/297.0
YRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRK
..  ..... .....||..|||||||||.||.||||    ....||||||....| . .....|||||| ||| |||||.||.|| .||| ....|.||.
lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

KCERYWPLYGEDPITFAPFKISCEDEQA--RTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGC
||..||||. ....|. .|.. . ...    .|| .||| ...   .|||....||| .||||.||.|..|.||.| |.||....  .. |...|||||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
||.|...|.|. ...|. ... ............|.||. |||| |||. ...|...|. |.|. 
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0045450 (Phosphotyrosine protein) phosphatases II 13-295 9e-91 300.1 In-house 14-305 (307) alignment 
Range on Protein: 13-295
Range on HMM: 14-305/307.0
RVQAMKSPDHNGEDNFARDFMRLRRLSTKYrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFI--------KGVYGPKAY
 .....    ..   ... | .|... ...    .... .....|| .|||||||||.||.||||.  ..| .|||||||...        .| . ....
llllvllllldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

VATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgEDPITFAPFKISCEDEQARTDYFIRTLLLE---FQNESRRLYQFHYVNWPDH
.|||||| .|| |||||.||..| .||| ....|.||.|| .|||.  ....|. .|.. . .|.   .| .||| ..   . .|||....||| .||||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

DVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.||.||...||.| ..||..|.  .. |...|||||.||||...|... . .|..... . ..... ....| ||. |||. |||. ...|...|. 
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0047943 (Phosphotyrosine protein) phosphatases II 22-292 3.3e-90 297.5 In-house 8-270 (273) alignment 
Range on Protein: 22-292
Range on HMM: 8-270/273.0
HNGEDNFARDFMRLRRLSTkyrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLtlktPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMI
 .| . ... | .|..| .      .... .....|| .|||||||||.|||||||    ....||||||....| . .....|||||| ||| |||||.
llgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGED-PITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
||.|| .||| ....|.||.||..|||| |.. ..|. .|.. . .|. . || .||| |..   .|||  ..||| .||||.||.|..|.|..| |.||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

YQEH--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
..|.  .. |...|||||.||||...|.|. ...|...    ...|..... .|.||. .||| |||.....|.. 
alealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealle
DSPc_SM00195 39-294 1.3e-89 295.4 In-house 10-262 (263) alignment 
Range on Protein: 39-294
Range on HMM: 10-262/263.0
STKYRTEkiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM
 ... ..   .| ..||..|..|||||.|||.||.||||. .  ...|||||||.|||   .|.|.|||||| .|| |||||.|| .| |||| ..|.| 
eestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGC
|..||.||||   ... ||  ... . ... .  .. .||| |....  |.|...|..| |||||.||.| .|.|.... ..| ......||..|||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||||....||. .. |...|    ...|....|.|.||...|||.|||  ...||....
gRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 39-294 1.3e-89 295.4 In-house 10-262 (263) alignment 
Range on Protein: 39-294
Range on HMM: 10-262/263.0
STKYRTEkiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM
 ... ..   .| ..||..|..|||||.|||.||.||||. .  ...|||||||.|||   .|.|.|||||| .|| |||||.|| .| |||| ..|.| 
eestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GRKKCERYWPLYGEDPITFAPFKISCEDEQART-DYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGC
|..||.||||   ... ||  ... . ... .  .. .||| |....  |.|...|..| |||||.||.| .|.|.... ..| ......||..|||||.
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||||....||. .. |...|    ...|....|.|.||...|||.|||  ...||....
gRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRD_pd Subfamily PTPRD 44-328 1.8e-89 295.9 In-house 34-315 (564) alignment 
Range on Protein: 44-328
Range on HMM: 34-315/564.0
TEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
...  .. . .|..| .||||..|...|||||.|.     ..||||||.||.|   .|||.|||||||.|. |||||.||.|. .|||  .  |.|..||
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

ERYWPLYgEdPITFAPFKISCEDEQARTDYFIRTLLL--EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAI
..|||   . . |.  .... |.|.  .|| |||. |  . ..|||   |||...||||.|| |  |.||.|. .|...|..  || .||||| ||||. 
hkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtf

CAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPE
..||. .. .|.    .  .... ....|.||   |||.|||  .|.||..  ... .  |..  ..  . ..|..... .. .| |
ividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtglele
0043336 (Phosphotyrosine protein) phosphatases II 19-293 6.9e-87 286.7 In-house 13-276 (278) alignment 
Range on Protein: 19-293
Range on HMM: 13-276/278.0
SPDHNGEDNFARDFMRLrrlstkyRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFW
 .  |.   . ..| .|       .. |.... .....||..|||||||||.|||||||.| .   |||||||....|   |....|||||| .|| |||
elllnlktllllefeel.......lsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMIWEYNVVIIVMACREFEMGRKKCERYWPlygEDPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
||.||..| .||| ....|.||.|| .|||   ....|. .|.. . .|.   || .||| ..    .|||  ...||..||||.||.|....||..  .
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

RKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|...|... |...|||||.||||...|... ...|. ..   ...... ..|.|.||..|||| .||. ...|....
realedsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 25-297 1.5e-86 285.8 In-house 31-292 (297) alignment 
Range on Protein: 25-297
Range on HMM: 31-292/297.0
EDNFARDFMRLRRLSTkyrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPS-QDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIW
   . ..|..| .|          .. .....||..|||||||||.|||||||. .  .  |||||||....| .  .....|||||| .|| |||||.|
ktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EYNVVIIVMACREFEMGRkKCERYWPLYGEdpiTFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH
|..| .||| ....|.|| ||..|||  |.   |. .|.. . ... . .|..||| ..  .||| ...|.|..||||.||.|....|... |.|.....
eqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
  .. |...|||||.||||...|... ...|. .    ...|.. ..|.| ||. |||| .||. ...|...|. . 
lpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
Y_phosphatase Protein-tyrosine phosphatase 58-291 1.3e-82 272.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 58-291
Range on HMM: 1-234/235.0
NVKKNRYKDILPFDHSRVKLtlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF
| ||||||||||.|..||||  |  ...|||||||..||   .|...|||||| .|. |||||.|...| .||| ... |.||.||..|||   |.. |.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

APFKISCE-DEQ-ARTDYFIRTLLLEFQNES---RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK
  .|. .. .|. . ..| .|.| |. ..|.   |...|.|| |||||.||.| .|.||.|  ..|..|... |...|||||.|||| ..|.|. .. |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
|..    ..|.....|.|.||...||. |||. ...||.
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 58-291 1.3e-82 272.1 In-house 1-234 (235) alignment 
Range on Protein: 58-291
Range on HMM: 1-234/235.0
NVKKNRYKDILPFDHSRVKLtlKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITF
| ||||||||||.|..||||  |  ...|||||||..||   .|...|||||| .|. |||||.|...| .||| ... |.||.||..|||   |.. |.
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

APFKISCE-DEQ-ARTDYFIRTLLLEFQNES---RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK
  .|. .. .|. . ..| .|.| |. ..|.   |...|.|| |||||.||.| .|.||.|  ..|..|... |...|||||.|||| ..|.|. .. |.
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
|..    ..|.....|.|.||...||. |||. ...||.
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 49-294 6.9e-82 270.0 In-house 2-246 (249) alignment 
Range on Protein: 49-294
Range on HMM: 2-246/249.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP
.. .....||..||||.||||.|||||||.      .||||||..|.| | .....|||||| .|| |||||.||... .|||.....|.||.||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LygEDPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAI
|  ......  |.. . ...   || .||| |.    .|||. ....|..||||.||.||...||.| ..||..|.  .. |...|||||.||||...|.
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
.. ...|.      ...... ....|.||. |||. |||. ...|...|.
ylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 8-297 5.3e-81 266.9 In-house 10-288 (293) alignment 
Range on Protein: 8-297
Range on HMM: 10-288/293.0
RKFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKYrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQ
.|| . |. ||.   . . .|. .. .|. . ..        ... |...| .||||..|||.|||||||.  . ...|||||||.|.|   |. ..|||
ekfeehvkkmka...dsdlrfseeyeelkavgkdq......avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD
||| .|| |||||.|| .. ||||  . .| |..|||.|||   |.|...   |..   |.  .|. ||.|..| ..|.|.. |.|.. ||||.||.. .
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk

SILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
..||..  .|...  .... || .||||| ||||.  |.|   .||.| .  .  ..| ...|.|..| . |||..||  .|... .|..|.
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald...rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 8-296 3.5e-80 264.4 In-house 5-282 (318) alignment 
Range on Protein: 8-296
Range on HMM: 5-282/318.0
RKFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKYRTEKiyptaTgEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQ
... ..|. ...   .|| .. ... || | . .  . |     .  .. | .|||| .||..||.||||. .. ...|||||||.| |    |||.|.|
edleshvrrlre...sGelllseeyerlsrseetvtslk.....s.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSS
.||..|. |||||.|| |  .|||  .| | |..|..||||  .......   ..  ..|   .|| .|.. .. .  .|||   |.|| .|||..||.|
aPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

FDSILDMISLMRKYQ-EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
  |.||..   .|.| ...  || .||||| ||||  .|.|   . .|| ..    .||. ....|.||   |||..|||... .. .  . 
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0042113 (Phosphotyrosine protein) phosphatases II 53-295 8.4e-80 263.0 In-house 4-244 (245) alignment 
Range on Protein: 53-295
Range on HMM: 4-244/245.0
GEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygE
....||..||||.||||.||.||||.   .. |||||||....| . .. . ||||||..|| |||||.||... .||| ..|.|.||.||..||||  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

DPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-HEDVPICIHCSAGCGRTGAICAIDYTWN
...|.  |.. . .|.   || .||| ..    .|||  ...||..||||.||.. ...||.....||... ... |...|||||.||||...|... ..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

LLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.|.. .   ...... ..|.| ||. |||| .||. ...|...|..
qlekel...gvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN6_pd Subfamily PTPN6 12-300 1.1e-79 262.6 In-house 11-303 (306) alignment 
Range on Protein: 12-300
Range on HMM: 11-303/306.0
QRVQAM-KSPDHNGEDNFARDFMRLRRLStkyrTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlKTPSQDSDYINANFIKGVY--GPKAYVATQG
|||. . |. .. .  .|  .| .|..      ..| .    |.| || .||||| ||||||.||.|. .   ..|||||||.||.      |.|.||||
qrvselekeeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPItFAPFKISCEDEQARTDYFIRTLLL---EFQNESRRLYQFHYVNWPDHDVPSS
 | .|| |||||.|. |  .|||. .| | |..|| ||||   |..  .   .... .|.. .|| .|.|..   ....|.|...|.|. .||||.||..
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

FDSILDMISLMRKYQEHE----DVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
 . .||... ... ||.       ||..||||| ||||..  ||   .|..  ..  .... .|.. .|.||   |||..|| .|..||..  |.. .|
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
0045098 (Phosphotyrosine protein) phosphatases II 50-295 1.2e-78 259.6 In-house 25-273 (278) alignment 
Range on Protein: 50-295
Range on HMM: 25-273/278.0
TATGEKEENVKKNRYKDILPFDHSRVKltlktpsqdsDYINANFIKGVygPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPl
  .. ...|..|||||||||.||||||          |||||..|.|   ||...|||||| .|| |||||.||... .|||.....|.||.||..||| 
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.

YgEDPITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDVPSSF--DSILDMISLMRKYQEH-------------EDVPIC
  ....|. .|.. ...|.   || .||||..        .||| ....||..||||.|||.   .|.|...  .|.....             .. |. 
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

IHCSAGCGRTGAICAIDYTWNLLkagkiPEEFNVFNLIQEMRTQRHS-AVQTKEQYELVHRAIAQLFE
.|||||.||||...|...   ||     .. ..... ..|.|.||.  |||..|||. .......|..
VHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0037934 (Phosphotyrosine protein) phosphatases II 53-294 3.6e-76 251.2 In-house 5-242 (243) alignment 
Range on Protein: 53-294
Range on HMM: 5-242/243.0
GEKEENVKKNRYKDILPFDHSRVKLtlktpsQDSDYINANFIKGVygPKaYVATQGPLANTVID----FWRMIWEYNVVIIVMACREFEMGRKKCERYWP
. ..||..||||.||||.|||||||      ..|||||||.|...  |. . |||||| .|| |    ||||.||... .||| ....|.||.||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

lygeDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKY--------QEHEDVPICIHCSAGCGR
    ...|. .|.. . .|.   || .||||||    ....|  ...||..||||.||.|....||... .|..        ..... |...|||||.||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGAICAIDYTWNLLkagkipeEFNVFNLIQEMRTQRHS-AVQTKEQYELVHRAIAQLF
||...|...   ||       ...... ....|.||.  |||| .||. ...|...|.
tGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 9-295 9.9e-76 249.8 In-house 9-284 (319) alignment 
Range on Protein: 9-295
Range on HMM: 9-284/319.0
KFIQRVQAMKSpdhNGEDNFARDFMRLRRLSTKyrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQG
.. .|..|..|   .||  ....|. |.  ...        . . .|||| |||||..||..|..||.|.    ...||||||.|| |    ....|||.
eLkerlkalas...tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqa

PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSS
||.||. |||||.||... |.|| ..  | .. |...|||   |.. ..  . .  |.|.   || || | |. ..   |.|.. .|.| .||||||| .
PlentiedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek

FDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
  |.||..  .|| .|. .. || .||||| ||||. ...| . . .|   .    .||. ....||||   ||..|||.... |. .  |
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 17-298 1.6e-74 245.5 In-house 6-280 (281) alignment 
Range on Protein: 17-298
Range on HMM: 6-280/281.0
MKSPDHNGEDNFARDFMRLRRLSTKYrtekiyPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVID
.|. ..| .  |....  |. . ..       ..   ...|||.||||..|  .|..|||.| .  ....|||||||..|. |.|.|.|||||. ... .
lkqlsqndnaGfieeyeklaaigvdn......tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEYNVVIIVMACREFEMGRKKCERYWPlYGEDPITFAPFKISCEDEQARTDYFIRTLLL-EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISL
||.|.||..| .|||  || | |. || ||||  ..  .... .... . |.... |  |.. | . ..|.|.. |..|..|||| ||..   .|.  . 
fWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrke

MRKYQEHED-VPICIHCSAGCGRTGAICAIDYTWNLLKagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
..|..|..  .|..|||||| ||||.  |.|   . ..  .  || .| ....|.| .|   |||  ||| |..|. . ..|.|
vlkltekktkaplvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-293 6.9e-74 243.8 In-house 9-289 (298) alignment 
Range on Protein: 6-293
Range on HMM: 9-289/298.0
ILRKFIQRVQAMKSpdHNGEDNFARDFMRLRRLSTKYRTEKiypTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVA
.|.. .|...|.|   ...  ..| .| ||.. | . ..|.   .  ..|.|| ||||| ||...|.||| |. .   ..|||||| |...  | .|..|
dlkaalqklaavkk..kkkltgyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafia

TQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDpiTFAPFKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVP
||.|| .|| |||||..|...  |||     |... |...|||  |..  |.  ...|   ..  .|. .|.| .. .  ...|.. |.|...|||..||
tqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvp

SSFDSILDMISLMRKYQEHED-VPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
.   |.||... .|..|..   .|. ..|||| ||.|. .|||    .|   |. .   ||. .. .|..|  ||||.|||  .. |. . 
enatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid...svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 11-296 3.8e-73 241.0 In-house 6-281 (288) alignment 
Range on Protein: 11-296
Range on HMM: 6-281/288.0
IQRVQAMKSPDHNGEDNFARDFMRLrrlstkYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPL
|. |.  .  . .....| ...  |         ||   . .|.. .| |||||..|||.|. ||||.     ...|||||..|.|  . |.|.||||||
ispvakvakksarnrtgfseeynsL......aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl

ANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSIL
|.|| |||....|...  |||     | |..|||.|||  ...|  .  ...   ...  .|.  |.|||| ... ... |..|  ||||.|| |   .|
adtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapll

DMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
.... .   .. .  || .||||| ||||   |.|   . ...    .  .|.. ....| || . |||..||| .......| |.
ellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Ptp69D_pd Subfamily Ptp69D 15-295 7.3e-72 237.1 In-house 11-287 (307) alignment 
Range on Protein: 15-295
Range on HMM: 11-287/307.0
QAMKSPDHNGEDNFARDFMRLRRLstkyrtEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTV
.|.|| ... .  .|... .| .       |    | ..||.||  ||||.|| .||. ||||.  . ..|||||||.||||    | ..| |.|. .|.
ealksrkrdtdfglakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveati

IDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgeDPITFAPFKISCEDEQARTDYFIRTLLLEFQN-------ESRRLYQFHYVNWPDHDVPSSFD
 ||||||.| .| .|||   . |. ||||..|||    | . .    . . .|.  .|| ||.| .  ..       .||.. |.|| .|.|  || .  
gDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

SILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
..|..|. .|. ....  || .||||| ||.| . |.|  .. |||    .. ..|. ....| ||   ||  |||. ..||...  .
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkae...dkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 49-294 8.5e-72 236.9 In-house 37-283 (305) alignment 
Range on Protein: 49-294
Range on HMM: 37-283/305.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP
..  |.||.|..|||.|.| ..|..|..|| |   .|||||||....|  . |.|...|||| ||| ||||.|.|. |. ||| ..  | |..||..|||
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

LYGEDPITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAI
    ..  | .|..  ..|.. .||..| | . .   ..||| . |..  .|||| || .  |.|..|  ..| |... .||. .||||| ||||. .|.
esktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiav

DYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|   . ||.    |. .||......|..|  .|||..||  .| |...| 
dialerlkkE...evvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPN3_pd Subfamily PTPN3 38-297 2.3e-71 235.0 In-house 21-278 (280) alignment 
Range on Protein: 38-297
Range on HMM: 21-278/280.0
LSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIK----GVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMAC
  . || ..   . .  | ||..||||.||||.|. ||||.    ....||||||...    .    . |.|||||||.|. |||.|.|| .. .|||  
feqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

REFEMGRKKCERYWPLyGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHC
   | ||.|| .|||   || .... |.. || |.... | .| |.|. ..  |.|.. |. |..||||.||.. ...|.... .||... .. |. .||
tlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
||| |||| . ... .  |. |    |.... .....|| || . |||..||..|  || ...|..
saGigrtGvlilletalaliea...aepvypldivrtmrdqramlvqtasqykfvCeailkvyeei
subfamily_PTPN13_pd Subfamily PTPN13 49-294 1.7e-70 232.4 In-house 28-269 (273) alignment 
Range on Protein: 49-294
Range on HMM: 28-269/273.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPsqdsdYINANFIKGVYGPKA--YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERY
 . .|.|.|| .||||...||.|..||||  ...     ||||..||   | .   |.|.|||| .|| |||.|.|| .. .|.|   | | |. ||.||
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPLYGEDPITFAP-FKISCEDEQARTDYFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhEDVPICIHCSAGCGRTGAICA
||   .....    .... .. | . .. .|.| .. .  .|||.. ....|.||||.|||| ...| ... .|. |. .  || .||||| ||.|.. .
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

IDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
||   .|..  |   ||.| ......| ||.. ||||.|| .|..|| ...
idvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN9_pd Subfamily PTPN9 54-292 5.6e-70 230.7 In-house 38-288 (297) alignment 
Range on Protein: 54-292
Range on HMM: 38-288/297.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED
..  |..||||.|.| .|..||.|. .   . ||||||||. |   .||..|||||| .|| |||||.|| .|..|||. |  |.|| || .||||  |.
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

PITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE-------------HEDVPICIHCSAGCGRT
 . |. ...|  . . . || .|.| ..   ..|||..  | .. |||. ||||  |.||... .|..|               .. || .||||| |||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|. ...|.. . |.     .  .|.. .. .||||  ..|| ||||. . |. .
Gtfitldiclsrleev...gtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRA_pd Subfamily PTPRA 52-294 1.1e-69 229.8 In-house 52-295 (330) alignment 
Range on Protein: 52-294
Range on HMM: 52-295/330.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYG
. .|||| .|||. .|||.|.||| |. |   ..|||||| ||.|    . ..|.|||...|| ||||||||..   |||     |  ..||..|||  |
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

EdpITFAPFKISCEDEQARTDYFIRTLLLE------FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
   .|.   ... |||.   || .| .|..       ...|| . |||.  |||  ||.    .|...  ..| .. .  || .||||| ||||. ...|
l..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

YTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
   . .|| ..    .||. ....|.||   |||.||||...... . .
avlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 58-297 1.5e-69 229.1 In-house 28-270 (274) alignment 
Range on Protein: 58-297
Range on HMM: 28-270/274.0
NVKKNRYKDILPFDHSRVKLTLKTPSQD-SDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED--
. .|||||.||| ..||| |. ...... |.|||||.|||  .  ||||||||||.||| ||||||.. .| .|||  .  |. ..||..|.|   .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

PITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDV---PICIHCSAGCGRTGAICAIDYTWNL
  ..  ..|  |.   | || .|.|.|. ....|... . | .||||..| . ...||..  ... .|.|.    |. .||||| ||||.  ||. . . 
serygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

LKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQlFEKQ
|..    .  .|.... ..| .|   |||.|||||.|||... ..|.
lre...eivvdvlkivcnlrldrGGmvqtseqyelihralcl.ylkr
subfamily_PTPRG_pd Subfamily PTPRG 10-294 2.3e-69 229.1 In-house 6-287 (563) alignment 
Range on Protein: 10-294
Range on HMM: 6-287/563.0
FIQRVQAMKSpdhNGEDNFARDFMrlrRLSTKYRTEKiYPTATGEKEENVKKNRYKDILPFDHSRVKLTlKTPSQDS--DYINANFIKGVYGPKAYVATQ
| . | ....   .|.  |...|     | ..  ...  .. . .|.|| .|||| .|...|.|||||. ..| ...  ||||||.|.| .  ||..|||
fakhvaslha...dgdigfseefe...alqsetiskd.ldaehsqkpenkrKnRylnivaydrsRvkls.plpgkkkklDYinAnyidGyqkskafiatq

GPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygEDPITFAPFKISCEDEQARTDYFIRTLLLEF-------Q-NESRRLYQFHYVNWPD
|||..|. |||||||| || ||||     | ||.||..|||   ....|.  ...  ..|.  . | .||| ..        | .. .. .|.|| .|||
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|.||..    | ..    . ...|  || .||||| ||||  ...|    |||  .  .  |||.... .|.||   |||.|||  .| |. .. 
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld...tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 46-293 7.6e-69 227.0 In-house 37-278 (315) alignment 
Range on Protein: 46-293
Range on HMM: 37-278/315.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
...|  .  | ||..|||| .|...|.|||.| |    ..|||.|||||.|   .. |.|.|||....| ||||...|...  |||     |  ..|.|.
qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek

YWPlygEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
|||   .. ... .. ..  .|.  |.| .|||   |... | ..|.||  ||| .|| .  .....|  ...... .  .| .||||| ||||. ...|
ywp...dkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld

YTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
   . ..|    .  .|.|.|. .| .|  .||. |||.... |. . 
avldqaea...enaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPRK_pd Subfamily PTPRK 52-291 1.4e-67 222.7 In-house 37-274 (314) alignment 
Range on Protein: 52-291
Range on HMM: 37-274/314.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlyg
.  |.|| .|||..|||..|.|||.|.     ..||||||..| .   |.|...||||| .|| ||||.....|   |||     | || || .|||   
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...

EDPITFAPFKISCEDEQARTDYFIRTLLLEF----QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYT
||  .. ..|. . . .. ... .|.. .|     |.| | . ||....||||||| |  ..|...  . | ||.|. .| .|||||.||||. .|||  
edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

WNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
 ....  ..    .||| ....|...   |.|.||| ... .| 
ldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 52-293 1.2e-66 219.5 In-house 3-241 (250) alignment 
Range on Protein: 52-293
Range on HMM: 3-241/250.0
TGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKkCERYWPLyg
 ..| .| .|||| ||...|.||| |  .   ..|||||| |..|  . ||..|||||| .|. |||||..|...  |||     |.... ...|||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..

EDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRR--LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTW
| . ..   ..|  ...  .|| .|.| |  .... .  . |.|.|.|||  ||    ..|.... ... |.. .. |. ..|||| ||.|| .|||   
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NLLkagKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
. |   |. .  .||..|. .|..|  ||...|||  |...| . 
erl...kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 54-296 1.3e-65 216.1 In-house 16-266 (270) alignment 
Range on Protein: 54-296
Range on HMM: 16-266/270.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGE
|   . | |||.||||  ..||.|   .  . . |||||...|. | .|.|.|..|||..|. .||||||| .|  |||.    | ||||||||||   .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DPITFAPFKISCED-EQARTDYFI-RTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD------SILDMISLMRKYQEHEDV--PICIHCSAGCGRTGAIC
. ....  ||.    ...... .| . | || . |.|||  |.|..|||| ||.. |      ..| |.  .|..... |   |. .||||| |||| . 
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

AIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
|.|.. .||.  |   . .| ..|.|.| .|   ||. ||||....|...  |.
alDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 46-310 2.5e-65 215.4 In-house 32-294 (315) alignment 
Range on Protein: 46-310
Range on HMM: 32-294/315.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
.||.. .. ...| ||||||.|||.|..|||| .   | ||||||| .||.|   |||.|.||||  .| |||||.....|  |||     |  . || .
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAID
|||    | . |  .|..  . .| ||  .| | .   .|||.. ||.. .|||. |.    |.| .|  ..  ..... .. .||||| |||| ...||
ywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

YTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE-KQLQLYEIHGAQKIA
   . .| .   .  .|||.....|..|   |||.|.| ... |. . .  ..  .  || .... 
evvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 45-293 3.8e-65 214.9 In-house 30-275 (515) alignment 
Range on Protein: 45-293
Range on HMM: 30-275/515.0
EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCE
 .||| .  ..| | ||||||.|||.| .|||| .   . .|||.|| .|...   |||.|.|||.  .| ||||.....||  |.|  .  |  . || 
pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

RYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAI
.|||    | . |  .|..    .| |.  .|.| .  ...|| . |||. .|||. ||    |.| .|  ..  ...   |. |||||| |||| ...|
kyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

DYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
|      | ..     .|||... .| .|   |||.||| ... |. . 
dsvvahakttr...mvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 43-292 8.4e-63 207.2 In-house 36-282 (297) alignment 
Range on Protein: 43-292
Range on HMM: 36-282/297.0
RTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGpkAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREfEMGRKK
 . .|.|. . ||  | .|.|||.|||.| |||||     . ||||.|| |.||.     ...|| |  .|| |||.|.....| .|||   . . . ||
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkk

CERYWPLYGEDPitFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPS--SFDSILDMISLMRK-YQEHEDVPICIHCSAGCGR
| |||.  |  .  |    .  .  . |. .  |.| .. ..    | . |...|.|||..|.   |  |.|..|| .|| ...... |. .||.|| ||
caryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

TGAICAIDYTWNllkAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|| ...||         |  .| ..|.|.. .| .|   |||||||..|. |. .
tgvlltidsvva...eakrekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-293 5.7e-60 198.3 In-house 57-292 (319) alignment 
Range on Protein: 54-293
Range on HMM: 57-292/319.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgRKKCERYWPLYGEd
. ..|  |||. .||.||...|||      . |||||| |..|   .. |.|.|||| ||. ||||||||||.  ||.        ..|| .|||| .. 
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.

pITFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDYTW
 |.   ||.. .  .   .| .| . |     ... |.. |||.  |||. || .   .. ..  .|. .  |..  .| .|||||.||||.  ..|   
.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

NLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ--L
. .|  |     .|.|.....| ||   ||   || ... |. .  |
drmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_PTPN23_pd Subfamily PTPN23 23-298 1.3e-59 196.4 In-house 12-284 (288) alignment 
Range on Protein: 23-298
Range on HMM: 12-284/288.0
NGEDNFARDFMRLRRLSTKYrtekIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVY-GPKAYVATQGPLANTVIDFWRMI
.|. .. . |  |..   |        ...   . ...|||..||||.||.||||     ..  ||||| |.|..  |   ..|||.||..|. |||.|.
dgktaldkkfkeleqkqdke....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNE--SRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK-
.|  . .|||   . |.|..|..||||   ... .| ..........    .  |.| ||....   . .   .. .||.. ||.| ...|...  ... 
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesa

YQE---HEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
|..   . ..|. .||||| ||||... .    . |..|..    .. .... .|.||.  ||.|||.. .  |. .  .. |
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 19-295 2.1e-59 195.8 In-house 13-284 (290) alignment 
Range on Protein: 19-295
Range on HMM: 13-284/290.0
SPDHNGEDNFARDFMRLRRlstkyrTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQD--SDYINANFIKGVYGPKAYVATQGPLANTVID
    .|.. |  .|..|        .|. . . .|  ..| ..||...|.. |  |. |  ..  .|   .|||| .|||    |.|.|||||. ||..|
nghakgnegfrnqfkmlds......gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPitFAPFKISCEDEQARTDYFIRTLLLEFQNE---SRRLYQFHYVNWPDHDVPSSFDSILDMI
||..||. .| |||| . . |.|..||  |||  . .   . .|.|   .|.. ..| .|.| .. .|.   .. . |..  ||....      .|| .|
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

SLMRKYQE-HEDVPICIHCSAGCGRTGAICAIDYTWNllkAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
. | | |  . . .| .|||.. ||..  ||.. | |     |.    .||......|.|.   |||..||..... . . ..
eemyktqrkrgntsivvHCSdtvgrsavfcaaattin...kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 56-293 3.2e-59 195.8 In-house 23-256 (284) alignment 
Range on Protein: 56-293
Range on HMM: 23-256/284.0
EENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgRKKCERYWPLYGEdpI
..|  |||. .||.||...|||      . |||||| ||.|   .. |.|||||| ||. ||||||||||.  ||.        ..|| .|||| ..  |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv..i

TFAPFKISCEDEQARTDYFIRTLLLEF---QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCGRTGAICAIDYTWNL
.   ||.. .  .   .| .| . |     ... |.. |||.  |||. || .   .. ..  .|. .  |..  .| .|||||.||||.  ..|   . 
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ--L
.|  |     .|.|.....| || . ||   || ... |. .  |
mkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_PTPRN_pd Subfamily PTPRN 41-294 3.8e-59 194.8 In-house 40-292 (297) alignment 
Range on Protein: 41-294
Range on HMM: 40-292/297.0
KYRTEKIYpTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMG
.|..|.   ......|.||||||.|..||.|||||||. .. ...|||||| .|        ||.|||||||.|| |||.|.||  ||.||. .|  | |
ayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg

RKKCERYWPLYGEDpiTFAPFKISCEDEQA-RTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCG
 |.|.||||  |..  ..  ...    |     ||..|.. |    ..|.| . |||.. ||...||.|  |.|..   . |       || .|||.|.|
vkqckrywpdeGse..vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|||. ..||   | |. |    | ..   .. .| ||.  |.||.|.|..  |.|.  
rtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 21-292 2.6e-58 192.3 In-house 15-276 (287) alignment 
Range on Protein: 21-292
Range on HMM: 15-276/287.0
DHNGEDNFARDFMRLRRLSTKyrTEKIyptATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
 ..|...|   |. | ... .   ...     .  ..| .|||...||. |  || |      .. ||||| ||.|    ||......|..||. .||..
hakgnegfknqftvleqvtqr..edev...thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

IWEYNVVIIVMACREFEMGRKKCERYWPLYGEdpITFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHD-VPSSFDSILDMISLM
|.. || .||| |.| |  ...| .|||      ... ...|.  .|.  ..| .|.| .. .|   . ... |... ||...  |..   ..| .   .
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy

RKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
.. . . . .| .|||.. ||..  ||.. | |  |        .||......| |.  .||| |||. .  .. .
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckt...eGviDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPN1_pd Subfamily PTPN1 45-292 1.5e-57 189.5 In-house 18-269 (290) alignment 
Range on Protein: 45-292
Range on HMM: 18-269/290.0
E-KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
| . .||.. ...|| ..|||.|. |.||||.||     ..| |||||....     . |. |||||.|||  ||.|.|| .   .||  .  | .. ||
easdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

ERYWPLYGE-DPITFA--PFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ--EHEDVPICIHCSAGCG
 .|||   | . ...    .|.    |. .  | .|.| ||    .|.| ...|||. |||  ||.|  . |...  .|.     ..  |  |||||| |
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|.|..| .|    |... .  .  .. . . |.| .|.  .||..| .. . || .
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN14_pd Subfamily PTPN14 50-294 4.9e-55 181.6 In-house 41-296 (300) alignment 
Range on Protein: 50-294
Range on HMM: 41-296/300.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYW
. |.. .||..|||.||.||....||.|.    . ...||||  || . | |   |...|||| .|| |||.|.|| .| .|||  .| | |..|. .|.
lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PLYG--EDPITFAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYVNWPDHDVPSS---FDSILDMI-SLMRKYQEHE-----DVPICIHCSAG
|  .  .. ..|  ||.. .  .  . .  ..| |..   .| | .. . |..||||.||.    | | |... |. || ...      . |. .|||||
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

CGRTGAICAIDYTWNLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
 |||| .   |   . |. .   || .. . .. .|.|| . |||  ||. |.... . .
vGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0041856 (Phosphotyrosine protein) phosphatases II 58-296 1.1e-52 173.6 In-house 1-173 (182) alignment 
Range on Protein: 58-296
Range on HMM: 1-173/182.0
NVKKNRYKDILPFDHSRvkltlktpsqDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefemgrkkCERYWPlygedpitf
|..||||.||||.||||          |.||||||.. | . .. ..|||||| .|| ||.||..|... .||...         .|.|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

apfkiscedeqartdyfirtlllefQNESRRLYQFHYVNWPDHDVPSsFDSILDMISLMRKyqehEDVPICIHCSAGCGRTGAICAIDYTWNLlkagkip
                         ... |  .|..|..||||.||. .|..||.|  ...    |. |. .|||||.||||...|... . |       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

eEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
 ...... ....| .|. .|.| .|| ....|. .|.. 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 53-294 1.3e-51 170.7 In-house 43-288 (325) alignment 
Range on Protein: 53-294
Range on HMM: 43-288/325.0
GEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMaCREFEMGRKKCERYWPLYGE
  | ||..|||.|.....|.||| |  |  . .||||||....   . . ..|.| ||..|. |.||.. ...  ..|.   |.. | ..|  |||    
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemg

DPITFAPFKISCEDEQARTDYFIRTLLLEFQN--ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE------HEDVPICIHCSAGCGRTGAICAI
.  || .....    .  .||  | | .   .  |.| . ||..  |.|  |.    ... .. |. . .|      .   || .||||| ||||.  ..
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

dYTwnLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
 |.  .|.      . ..|. .. .| .| | |.| .|| |.. |... .
.ys..alakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 49-291 2.5e-51 169.3 In-house 24-264 (283) alignment 
Range on Protein: 49-291
Range on HMM: 24-264/283.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPsqdsDYINANFIK---GVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCER
..     .|| .|||...|.| |  ||.|  ...    ||||| ||         | |...|.|| .||.|||.|... ... |||  .  |  |.|| .
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPLYGEdpITFAPFKISCEDEQARTDYFIRTLLLEFQ---NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAIC
|||  |   . . .| .. ..| .   . |. |||  .   ...  |  . ...| . .  .  .|.. .  .. . .|... || .|||.| |||.. .
yWPkrGs..edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

AIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI-A
|.  . . ...  .    .||. .. || ||  ||||..|| ||| ..  
aasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 54-303 4.7e-51 168.3 In-house 34-286 (287) alignment 
Range on Protein: 54-303
Range on HMM: 34-286/287.0
EKEENVKKNRYKDILPFDHSRVkLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYgED
|.  .|||||| |.||.|..|| |  ... . |||||||.. .    .|..|.|||.| || ||||...| ..  ...  || | .|.|| .|||   | 
eelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.ev

PITFAPFKISCEDEQ-ARTDYFIRTLLLE-FQ-NESRRLYQFHYVNWPDHDVPSS----FDSILDM---ISLMRKyqEHEDVPICIHCSAGCGRTGAICA
|.    . .   | .    .| .|.| |   . .|.| . |.....|||. .. .       .||.   | | |.    |  |. .|...| ||.| . |
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard..asevGPlvvhddvGiGrsGilla

idyTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEI
   |. |.. ..   . .| . .  .| .| . ||.  |. |.  |..  .. . ||| .
...tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpqlyva
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 45-292 9.1e-51 167.5 In-house 32-234 (392) alignment 
Range on Protein: 45-292
Range on HMM: 32-234/392.0
EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGrkkce
 .|||.....|| |.||||||.|||.| .|||| .   . ||||.|| .|...   |||.|.||| | .. |||||... ||  |.|  .  |       
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

rywplygedpitfapfkiscedeqartdyfirtllleFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAI
                                       .. |   |||...|||.|||    |.| .|  ..    .   |. |||||| |||| . .|
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
|      |  ..    .|||.. ..| .|   ||||||| ... |. .
dsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 24-292 6.4e-50 164.4 In-house 25-281 (290) alignment 
Range on Protein: 24-292
Range on HMM: 25-281/290.0
GEDNFARDFMRLR-R-LSTKYRTEKIYptatgEKEENVKKNRYKDILPFDHSRVKLTlktPSQDSDYINANFIKGVYGPkaYVATQGPLANTVIDFWRMI
. |..|....      | ..|   ||.     .|. ..|||||||.   | .|| |      .| ||. ||..||.  .  .. |||.|..||||.|||.
nvdelakeyleklkpylpvqylerkif.....dkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmv

WEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ---NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
 . .|  ||| |  .| |. |||.|.|    . .||  . . |  |. . .  |. .|   .     . .|. .. . |||. |. |  ..| ..  .||
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk

YQehedVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
       |. .||||| ||||.. ||. . ..|  ||   |... .|.. .|  | ..||   || .. ... .
as....GpvvvhcsaGiGrtGtfvaievglqilldGk...eldlldlvralrnsrlnsvqvdiqylalveilld
0051429 (Phosphotyrosine protein) phosphatases II 86-297 8e-50 165.3 In-house 4-228 (272) alignment 
Range on Protein: 86-297
Range on HMM: 4-228/272.0
SDYINANFIKGVYG---PKAYVATQGPLANTVIDFWRMiWEYNVVIIVMACREFEMGRKKCERYWP----------LYGEDPITFAPFKISCEDEQARTD
|.||||....| ..   |... ...||| .|. ||||. .|...  ||. ..|.|.|| ||.||||           ... .|..  . . .  |.  .|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YFIRTLLLE---FQNESRRLYQFHYVNWPDHDVPSSFdsILDMISLMRKyqeheDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFN-----VFN
| .|.|||.     .|.|.....|| .|||| ||..   .|....|...     . |. .|||||..||| ..|...    . .  | ...      ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

LIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQ
 ..|.| ||. |||| |||. ...|...|... 
aveelraqrpgavqteeqylflyeallellrsl
0049772 (Phosphotyrosine protein) phosphatases II 31-305 2e-49 164.3 In-house 21-291 (314) alignment 
Range on Protein: 31-305
Range on HMM: 21-291/314.0
DFMRLRRLSTKYRTEKIypTATGEKEENVKKNRYKDILPFDhSRVKLtLKTPSQDSDYINANFIKGVygpKAYVATQGPLANTVIDF----------WRM
 ...| |.|  . .|..  . .. ...| .||||.||||.| .||.|  . | ..||||||....|.   ....|||||| .||.||          |||
lllvlnrrslsvlpelt..ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

I--WEYNVVIIVM---------------------ACREFEMGRKKCERYWPLYGedpitfapfkisceDEQARTDYFirtlllefqneSRRLYQFHYVNW
.  ...|| .|||                      ..  . |   ......|.               .|.   ..|           .|. ........
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk..............eelydpelf...........erlgikylripv

PDHDVPsSFDSILDMISLMRKYqeHEDVPICIHCSAGCGRTGAICAIDYtwnLLKAGKipeeFNVFNLIQEMRTQRH-----SAVQTKEQYELVHRAIAQ
||...| ... ..... .....  ... |. .||.||.||||  ....|   |.|. .    ...   ....| .|.     ..... |||| ...|. .
pDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaay...lmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealle

LFEKQLQLYEIHG
....... ||.  
ylkflkkfyeyle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 55-294 5.5e-49 161.8 In-house 38-277 (307) alignment 
Range on Protein: 55-294
Range on HMM: 38-277/307.0
KEENVKKNRYKDILPFDHSRVklTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
 . | .||||.|.   |..|.   .|..   |||| ||..     || ....|||| ||. .|| |. . .|  ..| |.  |... |||.||||   . 
fsantdknryqdvkcqdkgri..vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

ITF--APFKISCEDEQ----ARTDYFI--RTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRkyqeHEDVPICIHCSAGCGRTGAICAIDY
 .|  ||  || ..      |  . .|   || ... ..|| . .. . ||||. ||    . ..... .|     .  |. .||||| ||.|.| || .
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaisl

TWNLLKAGKIPEEFNvfNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
  . . ||.   . .  .|..|.|.||| |.||. ||  .|| . . |
vqdkmiaGinckdmk..klveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 55-290 9.7e-49 160.7 In-house 4-236 (239) alignment 
Range on Protein: 55-290
Range on HMM: 4-236/239.0
KEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlygED
|  |  |||| .|. .||||| |   .    ||||||....   | ||||.|||| .. .  |||||.|.   ..|||     |  .||| .|||   . 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...ds

PITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNLL
   .. ....    .  .|| |||...    | | | .||.|.  |||. ||    ..| .   . |       |  |||||| |||||.  ||    .|
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...aml

KAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
.  |  .  ..|| .. .| .|   ||| ||| ..| |.
rqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 54-290 9.8e-49 160.7 In-house 4-237 (239) alignment 
Range on Protein: 54-290
Range on HMM: 4-237/239.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPlygE
.|  |  |||| .|. .||||| |   .    ||||||....   | ||||.|||| .. .  |||||.|.   ..|||     |  .||| .|||   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...d

DPITFAPFKISCEDEQARTDYFIRTLLLE--FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDytwNL
    .. ....    .  .|| |||...    | | | .||.|.  |||. ||    ..| .   . |       |  |||||| |||||.  ||    .
stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid...am

LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
|.  |  .  ..|| .. .| .|   ||| ||| ..| |.
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 57-290 1e-48 160.7 In-house 2-235 (237) alignment 
Range on Protein: 57-290
Range on HMM: 2-235/237.0
ENVKKNRYKDILPFDHSRVklTLKTPSQDSDYINANFIKGVYG-PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPI
||  |||| .|  .|||||   || .  .||||||...||. | || |.|.|||| ..  |||.|.|. .  .|||     |  ..|| .|||   ..| 
enkiknrygnivaydhsrv..vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpa

TFAPFKISCEDEQARTDYFIRTLLLEFQN---ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEH--EDVPICIHCSAGCGRTGAICAIDYtwnL
..  . .|   ... .|| .|.|||  .    | | ..|...  |||. ||    ..| .   . .  .|  |  |  |||||| |||| .  ||    .
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida...m

LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
|.  |  .  ...| .. .  .|   .|||.|| ..|..|
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_CG7180_pd Subfamily CG7180 50-288 5e-47 155.0 In-house 34-284 (296) alignment 
Range on Protein: 50-288
Range on HMM: 34-284/296.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRkKCERYWPL
 |.| ..|| .|||. ...|.|. || |.     ..|||||| .. .   .|.|. |..|  .|| .|||.... ..  .|. ...|.. . ..  ||| 
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

YGedPITFAPFKISCEDEQARTDYFIRTLLLEFQ------------NESRRLYQFHYVNWPD-HDVPSSFDSILDMISLMRKYQEHE-----DVPICIHC
 .     . .. .    |.  ..  |||. |  .             | | . .|..  |.  . ||.|  ......  .|...|.        |.....
ks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGCGRTGAICAIDYTWNLLKagkIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHR
| | .|.|. .||| . .|..   . ||..||. .. .| .|   |...|.|  .  
sdGasRsGvylaidanlelve...keeevdvFeavktlrrsRpqLvenveeYkyiYd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 46-294 2.5e-46 152.8 In-house 28-293 (301) alignment 
Range on Protein: 46-294
Range on HMM: 28-293/301.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTP--SQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
.  ..  | .||| . ||.|.| ..|. |. |. |.   ..  .||||..|.|.   |...|.|||. .|..||||.||.. .| ||| . . |  ..||
edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskc

ERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN-----------------ESRRLYQFHYVNWPDHDVPSSFDSILDMIS-LMRKYQEHEDV
|.|||   ..  .| ||..   .||.  |. || | .  |.                 .|. . |.. ..||.. |      .|  |   . . |  .  
eqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg

PICIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
|. .|||.. .|.|  |... .    ||  .    .||.... .| ..  ||.| |||  .. .| . .
pvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_ptpA1_pd Subfamily ptpA1 50-243 3.2e-46 152.9 In-house 39-248 (418) alignment 
Range on Protein: 50-243
Range on HMM: 39-248/418.0
TATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYgPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP-
|. |.|. |  |||| .||| .|.||.|      . |||||||.| | | || ...||||| ||. |||||.||  . ||||  || |  | ||.|||| 
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

--------LYGEDPITFAPFKISCED--EQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ------EHEDVPICIHCS
        .||.    |  . .   .  ..   .   | . | |. |.| . |..|  ||||..|   . . ...  . . |         .||| .|||
qiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGCGRTGAICA
|| ||||..|.
agvgrtgtfct
0036282 (Phosphotyrosine protein) phosphatases II 86-287 1.4e-45 150.5 In-house 2-163 (174) alignment 
Range on Protein: 86-287
Range on HMM: 2-163/174.0
SDYINANFIKGVYGPKAYVATQGPLAntvidFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLygedpitfapfkiscedeqartdyfirtlllEFQNE
||||||......| .. ..|.|||||     ||.|..|... ..|| ..|.|.|. || .|||                                  . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRRLYQFHYVNWPDHDVPSSFDsILDMISLMRKYQEH-EDVPICIHCSAGCGRTGAICAIDYTWNLLKagkiPEEFNVFNLIQEMRTQRHSAVQTKEQYE
.|  .|..|..|||| ||..   .|............ .. |. .|||||.||||...|...   .|.    .   ....|..|.|.||. .||| .||.
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyr

LVH
 ..
fly
0043147 (Phosphotyrosine protein) phosphatases II 84-287 2.5e-45 149.6 In-house 3-154 (172) alignment 
Range on Protein: 84-287
Range on HMM: 3-154/172.0
QDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREfemgrkkcerywplygedpitfapfkiscedeqartdyfirtlLLEFQ
..||||||......| |. ..|||||| ||. |||||..|... .||.....                                           |.  .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

NESRRLYQFHYVNWPDHDVPsSFDSILDMISLMRK-YQEHEDVPICIHCSAGCGRTGAICAIDYTWnllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQ
...|  .|..|..||||.|| ... .|........ ... .. |...|||||.||||...|... .         . ..... ....|..|  |||...|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YELVH
| ...
yrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 22-291 2.9e-45 149.5 In-house 16-276 (439) alignment 
Range on Protein: 22-291
Range on HMM: 16-276/439.0
HNGEDNFARDFMRLRRLSTKYRTEKiyptATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMI
.| .. |   |  .   | .|. .     .   .| .  ||||||. .|||.|| |        | |||||.||| | .| |.|||||  .|. ||||..
knkqeifkeifekinstspdyacia....slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlv

WEYNVVIIVMACREFEMGRkkcerYWPlyGEDPITFAPFKISCEDEQARTDYFIRTLLLE----FQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMR
.| ..| ||| .  .|  .     |||   .. . .    . .. .    .| || . .       .  | . ||||. |||..||.    .||..  . 
iekktvtivmltnlvesyk.....ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain

KY-QEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAgkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIA
   ...|  |. .||||| ||||.| |.| . . ||.    .. ..  ... .| ||.  ||.  || ... |. 
sandkeeygpvvvhcsagvGrtGtiialdialeqlkl...enkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 55-298 3.6e-45 149.0 In-house 45-291 (305) alignment 
Range on Protein: 55-298
Range on HMM: 45-291/305.0
KEENVKKNRYKDILPFDHSRVKLtlkTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
. .. .||||||.  .|. ||||    ..   .|| ||..     || .. || || .|  ||| | .. .|  | | |   | | |||  |..   .| 
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

ITFA--PFKISCEDEQARTDYFIR---------TLLLEFQ-NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQehedVPICIHCSAGCGRTGAIC
..|     |||   | . |  | .          |..|   ...|.  ..|...|||  ||..  .||...   |  .     || .||||| ||||.. 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpivvhcsagigrtgsvv

AIDYTWNLLKAGKIPEEFNvfNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL
 ..|  . | ||.| |. .   ..| .| ||  ..|| .|| .||. | . |.|. 
mleyildqllagqiiedtd..kilqkireqrnnsiqtdaqylfvhqvilnyfrkkk
0046846 (Phosphotyrosine protein) phosphatases II 80-295 6.1e-45 148.4 In-house 6-174 (176) alignment 
Range on Protein: 80-295
Range on HMM: 6-174/176.0
KTPSQDSDYINANFIKGVYgpkaYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPItfapfkiscedeqartdyfirtll
 ..  |.||||||.| | .    ..|||||| .|. ||..|..|... ..|. . |.|.|| || .|||.. .  |                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lefqnesrrlyQFHYVNWPDHDVPSSfDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDytwnLLKAgkiPEEFNVFNLIQEMRTQRH-SAVQ
           |.....||||.||.. . .|... ..|.....   |. .|||||.||||...|..    ||.       ..|.. ....| ||.  |||
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llel...ekglsveealalvreqRplgavq

TKEQYELVHRAIAQLFE
| |||. ..... .|..
tpeQyrflyefellllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 56-291 4.2e-44 145.3 In-house 35-266 (281) alignment 
Range on Protein: 56-291
Range on HMM: 35-266/281.0
EENVKKNRYKDILPFDHSRVKLTLKTPSQDS-DYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDP
  | ||||| .|  .| |||.| .| | ..| ||| ||.|.  .  . |. ||||  .|  |||||||. |   ||| |.  |  |.||  |.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

ITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSildMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDYTWNLLKAG
. |  . .| ||           | | .. |.| . .. . .||| .|| | .    |. ..|| . .   |  |||||| ||.|.. |.. . . ... 
lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev...mlkilrkirars.tppvihcsagvgrsgtlmaveialqsihsh

K-IPEefnVFNLIQEMR-TQRHSAVQTKEQYELVHRAIA
  .|.   . ...  .| | | ..||| .|| |. . . 
ftlpd...ikqivshlrvtgraasvqtlqqymliwkvll
0049260 (Phosphotyrosine protein) phosphatases II 93-287 1e-42 140.7 In-house 1-143 (152) alignment 
Range on Protein: 93-287
Range on HMM: 1-143/152.0
FIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWplygedpitfapfkiscedeqartdyfirtlllefqnesrrlyQF
||.|.. |....|||||. ||. |||||..|... .||| ....|.|. |||.|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWnllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVH
....|||| ||.. . .|... ...|...... |. .|||||.||||...|... .           ..... .. .|..|  ||....|.....
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 54-290 1.8e-42 140.2 In-house 29-291 (297) alignment 
Range on Protein: 54-290
Range on HMM: 29-291/297.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPsqDSDYINANFIKGVYG--PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYG
 ..  ..||||.||| .| .||||    .  ..|||||...       .  |. .|||| .|| |||....| .| .||| ..  | ||.||  |||   
krnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

EDPITFAPFKI----SCEDEqaRTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD--------------------SILDMISLMRK-----Y--Q
..  . . . .    |  ||      ..  | | ...||| .    ...|||| ||| ..                    ....|.. |       .  .
qerlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae

EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefnVFNLIQEMRTQRHSAVQTKEQYELVHRAI
   .... .||||| ||.| .   |   . |. ..||.   |  ... .| ||   ||| ||.||.. |.
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripd...vaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 24-295 2.3e-41 136.4 In-house 22-290 (305) alignment 
Range on Protein: 24-295
Range on HMM: 22-290/305.0
GEDNFARDFMRLRRLSTKYRTEKIYpTATGEKEENVKKNRYKDILPFDHSRVKLTlkTPSqDSDYINANFIKGVYGP-KAYVATQGPLANTVIDFWRMIW
| |..  .| .| . .    |....  |    . .. ||||.|.   |.| |||    ||  |||| ||..     | | ....|||| .|. .|| |. 
gvdklreefrglakytrpdmtqvaf.nanqsadiaitknryqdvpcqdqsavkld..kps.psdyihanyvgcpmipekrficaqgpldqtidefwwmvi

EYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAP----FKISCEDEQAR-TDYFIRTLLLEF-QNESRRLYQFHYVNWPDHDVPSSFDSILDMISLM
. .|  ||| |.  |.|. || .|||.   .  ..       ..|      | ..  | .| | .  ...  . .... .|||  ||    . |...| .
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai

RKYQehedVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEefNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
|  .    ||| .||||| ||||.| ||.|  . .   |      . .|.. .| ||  ..|.  ||  .|| . . | 
rgsk....vpivvhcsagigrtgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 25-299 1.5e-39 130.7 In-house 5-264 (267) alignment 
Range on Protein: 25-299
Range on HMM: 5-264/267.0
EDNFARDFMRLRRLSTKYRTekIyptATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSqdsdYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEY
| .. ..|  ....|..  |  |   ..   |.| ..||. | ||.|..|| |  |.      |||| ...| .  .|...||.|| ||. ||. .| ..
eceiekefelikkisdtsst..i...sqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdq

NVVIIVMACREFEmgrKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLY-QFHYVNWPDHDVPSSFDSILDMIsLMRKYQEHE
.| .||.  . |.    .  ..||    .   .  . .    |.   || | || |.|.||| .    ..| .|        .   |  | | ..  |  
kvpvivlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgi.laknqleng

DVPICIHCSAGCGRTGAICAIDYTwnlLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
. |. ..||.| ||.|.   ||     |.  |  .  ..|......| || . |.|||.|  .|. .|.  | .|.
nrPlvvacsdGvGrsGtflvidsq...leraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
0051082 (Phosphotyrosine protein) phosphatases II 86-290 1.4e-35 117.4 In-house 3-149 (151) alignment 
Range on Protein: 86-290
Range on HMM: 3-149/151.0
SDYINANFIKGVygpkaYVATQGPLAntviDFWRMIWEYNVVIIVMACREFEMGrkKCERYWPLYGedpitfapfkiscedeqartdyfirtlllefqne
|||||.... |      . ...||||    ||.....|...  ||. . |.|.|  .| .|.| .|                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqeHEDVPICIHCSAGCGRTGAICAIDYTWnlLKagkipeeFNVFNLIQEMRTQRHSAVQTKEQYEL
 ..........|||...| |||..|....|...   ... |. .|||||.||||...|..     |.       ....  ..|.| .|. .||...|. .
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqflf

VHRAI
...|.
qlfal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 58-292 1.5e-35 117.7 In-house 43-269 (288) alignment 
Range on Protein: 58-292
Range on HMM: 43-269/288.0
NVKKNRYKDILPFDHSRVKLTlktpsQDSD-YINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPIT
|  ..||...   | .||||.      |.| ||.|| .     ..  . .| ||  |.  .|.|. | .|  ||| |.  | |..| . |.|.   . . 
nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FAPFKISCEDEQARTDYFIRTLLLEFQNESRR---LYQFHYVNWPDHDVPSSFDSILDMISLMrkyqEHEDVPICIHCSAGCGRTGAICAIDYtwnLLKA
.  .     ...|  |  ..  ||  ..|      . . |. .|.|. || .. | | ..  .    .  . || .|.||| ||||..  |      |..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlilili...ales

GKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
 ....   . .|....| .|  |.||. ||  ||| . .
lrlddflgirsllaklreerfkaiqtemqylyvhrcvle
0044763 (Phosphotyrosine protein) phosphatases II 69-295 1.6e-35 117.7 In-house 1-172 (178) alignment 
Range on Protein: 69-295
Range on HMM: 1-172/178.0
PFDHSRVKLTLKTPSQDSDYINANFIKgvygPKAYVATQGPlantvIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEdpitfapfkiscedeq
|.|..||.|.     . ||||||..|     |  |.....|      |......|...  ||. . |.|.|. || .|||   .                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

artdyfirtlllefqnesrrlYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLlkagkipeEFNVFNLIQE
                     .|......|||.||.... .|... ....... .. |. .||||| ||.|...|... . |         ..... |..
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRTQRHsAVQTKEQYELVHRAIAQLFE
.| .|  .|.. .|.. ...   .|..
vrerRp.ivpnpgqlrqLyefelrllk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 56-290 2.1e-35 116.8 In-house 50-286 (310) alignment 
Range on Protein: 56-290
Range on HMM: 50-286/310.0
EENVKKNRYKDILPFDHSRVKLTLKTpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDpI
.....|||| |..  | |||||..   |.  ||| ||..|  |  .... .||||  |.|||||||..     |.. |.  | || ||  |||  |    
kkymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt.e

TFAPFKISCEDEQArTDYFIRTLLLEFQ------------NESRRLYQFHYVNWPDHDVPSSFDSILDmislMRKYQEHEDVPICIHCSAGCGRTGAICA
|.   ...   | .  .. |  | . |              .  |.   .. ||||  ||      .      |   .    |  .||||| .|.....|
tygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvva

IDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
...... |. |.   . .. ... |.. .|   .||. || ...|  
lklkidkldrgl...kvdaeevktellksraiciqtelqyliidrvr
PTPc_DSPc_SM00012 189-291 1.7e-33 110.3 In-house 2-104 (105) alignment 
Range on Protein: 189-291
Range on HMM: 2-104/105.0
LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHED--VPICIHCSAGCGRTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELV
....|| .|||| ||.. ||||...  ..| .....   |...|||||.|||| ..|.|. .. |....  .|...|....|.|.||...|||.|||  .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

HRAIA
.||..
yrall
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 89-283 2.4e-33 110.2 In-house 78-270 (301) alignment 
Range on Protein: 89-283
Range on HMM: 78-270/301.0
INANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQART--DYFIRTLLLEF---Q
| ||.|.    |. ..|||||| ||  ||| |.  |.|  ||| ... |   .||| | |.  .. .    |||  ....     .   ||| .|    .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEhedvPICIHCSAGCGRTGAICAIDYTWNLLKAGKipeEFNVFNLIQEMRTQRHSAVQTKEQY
 ..| .  . |..|.|..|| |   . |.. |..| ..    || .||||| ||. |  . .|  . ..| .   . .. . ....| .| ..|||..| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteylareveadp...tieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 55-289 8.8e-33 108.5 In-house 32-265 (285) alignment 
Range on Protein: 55-289
Range on HMM: 32-265/285.0
KEENVKKNRYKDILPFDHSRVKLtlKtpSQDSDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGED
 | |   ||| |.   . .|| |  |   .| ||| |....       .|..||||| .|. |||.||.. ..  ..| |  || | .||  |.|    .
yeanpdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PITFAPFKIS---CEDEQ-ARTDYFIRTLLLEFQNESRRLYQFHY--VNWPDHDVPSSFDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICAIDYT
 . |  ..|.   |..|  | | .   |..   .  |  ||  |     |||.  |     ....   ..| . .|  |||.||||| ||| ..  |||.
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidya

WnlLKAGKIPeEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA
   ..  . | . .......|||. |  |||.. |. ...  
t..irimenp.niemldivremramrfqavqshmqflflyvv
subfamily_egg_pd Subfamily egg 43-296 3.9e-32 106.2 In-house 25-272 (307) alignment 
Range on Protein: 43-296
Range on HMM: 25-272/307.0
RTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMgrKK
 . .  .  |  ...| .| | | .   | ||||| |.      |.| || .||      .. .| || ||| |||||... .|  |||     |   ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CERYWPLYGEDPITF--APFKISCEDEQARTDYFIRTLLLEFQNESR-RLYQFHYvNWpDHDVPSSFDSILdmiSLMRKYQEHeDVPICIHCSAGCGRTG
|| |||   .|.. .    ..| . . . ..| . |   |      .  ..  |. .. | .  |   | |    ..|| ..    |. ...  |. ...
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehw.qg.dvnnssdvyspl...rvlrklrnl.skpvvvqdilGvskaa

AICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK
.. ||. .   |  | |   . | . .. .| .|. .|..  .| .|.| .. .|  
tlvaieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_CG42327_pd Subfamily CG42327 60-213 1.6e-28 94.3 In-house 30-187 (319) alignment 
Range on Protein: 60-213
Range on HMM: 30-187/319.0
KKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVY-GPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLY--GEDPIT
.|.|. ...|. ..|| |  ..  . . |..|....|    |  |.|.| .| ..  ||||..|| .  .|| ..  .| | |.| .|.|    ...  .
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FAPFKISCEDEQARTDYFIRTLLLEF--QNESRRLYQFHYvNWPDHDVPSSFDSILDMI
.  ....  . ...  |.| ||||    ..||| |  . | .|.. .||..  ... |.
yGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-298 2.2e-27 90.6 In-house 46-281 (312) alignment 
Range on Protein: 61-298
Range on HMM: 46-281/312.0
KNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPL-----YGEDPI
 ||| .|  .|  |  |.     ..  || |||.| .  |. .|.||||| ||.  ||..      . |.. |   | | .|| .|          ||  
lnrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

TFAPF----KISCEDEQARTDYFIRTLLLEFQNESrRLYQFHYVNWPDHDVPSSFDSILDMISLMRKyqehEDVPICIHCSAGCGRTGAICAIDytwNLL
 .. .    .|     .  |   .. ..    .|| .| .. .  |||| .| | |. | ..| ..|    .  |.  ||||| ||||... |.    ..
vyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalie...smi

KAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL-FEKQL
 | . |   || .    .| .|  .|..  ||  . |.. .. . | |
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
0048076 (Phosphotyrosine protein) phosphatases II 146-293 4.1e-27 90.0 In-house 2-142 (145) alignment 
Range on Protein: 146-293
Range on HMM: 2-142/145.0
YWPLYGEDPITFAPFKISCEDEQA--RTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEdVPICIHCSAGCGRTGAICA
|||    . . . ..   .. |.      . . .|  |.....|  .|..|..||||.||.... .|... .........  |. .|||||.||||...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL
..  .         . ..... ....|.||. ||.. .|.. ..... .|
aylmll........lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 58-153 1e-25 85.2 In-house 47-156 (350) alignment 
Range on Protein: 58-153
Range on HMM: 47-156/350.0
NVKKNRYKDILPFDHSRVKLT--------LKTPSQDSDYINANFIKGV-----YGPKA-YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKC
   |||||.|||..||||||          |   . .||||||..|         |.  |.|||.|| .|| ||...| . .| .|..   ..|....||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ERYWPLYGED
.|||.  . |
yrYWqegsyd
0048179 (Phosphotyrosine protein) phosphatases II 173-288 2e-24 81.4 In-house 31-139 (144) alignment 
Range on Protein: 173-288
Range on HMM: 31-139/144.0
YFIRTLLLEFQNESRRLY--QFHYVNWPDHDVPSSFDSILDMISLMRKYQEhEDVPICIHCSAGCGRTGAICAIDYTWnllkagkiPEEFNVFNLIQEMR
. . .|  |. .|.   .  |.....||||.||.... .|... ......| |. |. .|||||.||||...|..  .         . ..... ....|
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

TQRHSAVQTKEQYELVHR
..|  ||.. .|.. ...
srrpgavpnpgqlrfLle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 70-302 2.5e-24 80.9 In-house 30-268 (290) alignment 
Range on Protein: 70-302
Range on HMM: 30-268/290.0
FDHSRVKLTLKTPSQDSDYINANFIKGVYGpKAYVATQGPLANT-------VIDFWRMIWEYNVVIIVMACREFEMGRK----KCERYWPLYGEDPITFA
. ..|| |        .||| ||...   |  . ..|| |....       . .|| |. . .|  .|| |   |  ..     |..| | . .. ..| 
veatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

PFKISCEDEQARTDYFIRTLLLEFQNESRR-LYQFHYVNWPDHDVPSSFDSILDMISLMRkyqeHEDVPICIHCSAGCGRTGAICAIDYTWNLLKagKIP
 ....| .  .  |  .|.|...|..|    .    ...| .  |. .  ..|..|. ..     .. |. .||  |  |  |. ||.  . ..   .  
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkia..ets

EEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL-QLYE
..... ......| ||  |.......  |  .|  |. . | | .|
gsvkledvlkalrkqralaitsalelafvdagivllaievldqfae
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 109-285 6.2e-22 72.4 In-house 99-279 (302) alignment 
Range on Protein: 109-285
Range on HMM: 99-279/302.0
PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFI-----RTLLLEFQNESRRL------YQFHYVNW
|  .|.  .| .| .||| |.|  |   | . |||  |.    .. ..|  . .   . .   . |      .   .|..|| ..         ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDVPSSFDSILDMISLMRKYQEHedvpICIHCSAGCGRTGAICAIDYTWNLLKAGKIPeefNVFNLIQEMRTQRHSAVQTKEQYEL
|||  |   .. ||..     |..     . .||||| ||||.. || |  .| .  |.    .. .... .|. |. |||...|   
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 57-292 7.5e-22 72.3 In-house 46-277 (303) alignment 
Range on Protein: 57-292
Range on HMM: 46-277/303.0
ENVKKNRYKDILPFDHSRVKLTlktpsqDSDYINANFIKgVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLyGEDPIT
.|..|||. |.. .|||.|||.      || || |.... .   |  . || ||. |  |||.|| | .|  ...   . |. .   .  .|   .| . 
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.nqdflk

FAPFKISCED-EQA--RTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSS-----FDSILDMISLMRKYQEHEdvPICIHCSAGCGRTGAICAIDYTW
|    |   .  .      . .. | .   .    |.  || .||  ..||         | .. |..||| . .  |      .||||.|... .. . 
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst..ptvymslsgcgragtfalfetah

NLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
  |.. .    ... . .. .|  |  |||   |. .|.  .|.
lslhseq..asldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 185-292 2.7e-21 70.4 In-house 87-192 (440) alignment 
Range on Protein: 185-292
Range on HMM: 87-192/440.0
ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAIDytwNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQY
||| | |.||  |||. ||     .| ||  . . ||.  . |. .|||||.|||| | |.|   ..|.  |  .. ..|..|. || .|   ||| |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavd...silreakrsdqidifsfinsmrnnrpqmvqtpeqy

ELVHRAIAQ
 .|| |. .
afvheavle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 57-299 2.3e-19 64.0 In-house 50-290 (302) alignment 
Range on Protein: 57-299
Range on HMM: 50-290/302.0
ENVKKNRYKDILPFDHSRVKLTlktpSQDSDYINANFIKGVYGPKAYVATQGPLANTV---IDFWRMIWEYNVVIIVMACREFEMGRkKCERYWPLYGED
.|.|||. .|.   |. .|||.     .  .|.||  ..     .  . .| |  ...    .||||... ..| .|.. .| |. .   . ..|.  .|
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

PITFAPFKI-----SCEDEQArTDYFIRTLLLEFQNeSRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTW
  ..  . .     .  .|.. | | |  |  .. | |      .  ||... || .. ..   .  . . ... | .. |    |.|| ||. .   . 
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsn.svlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

NLLKAGkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
. |..|   .| |. .... .|.|| .||.. .||  ...|.. .. |...
eklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 105-282 4.5e-19 63.5 In-house 39-209 (255) alignment 
Range on Protein: 105-282
Range on HMM: 39-209/255.0
AtqgplanTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDeqARTDYFIRTL--LLEFQ--NESRRLYQFHYVNWPDH
        ||  |...|   .   .|| |   | |..||..|.||  ..   .|  .... .  . .|  .|||  ....    . . .  ..|  |...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

DVPSSFDSILDMISLMRKYQehedvPICIHCSAGCGRTGAICAIDYTWN-LLKAGKIP--EEFNVFNLIQEMRTQRHSAVQTKEQ
  |     || .. ..|. .     .. .|||.| ||. |   ... .  .... .     |..  .|..|.| .|..|..|  |
naPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq
subfamily_hpo-7_pd Subfamily hpo-7 100-280 1.1e-18 62.1 In-house 42-213 (263) alignment 
Range on Protein: 100-280
Range on HMM: 42-213/263.0
PkayvatqgpLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQArtDYFIRTL--LLEFQ--NESRRLYQFHYV
          | .|.  |...|   .   .|| |   | |..||..|.||  ..   .|  .... . |   |  ..||  |  ..   . . . .. |.
l.........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysyk

NWPDHDVPSSFDSILDMISLMRKYQEhedvpICIHCSAGCGRTGAICAIDYTWN-LLKAGKIP--EEFNVFNLIQEMRTQRHSAVQTK
 |...  |  . .|| .. . |. ..     . .|||.| ||. |   ..  .  .... .     |..  .|..|.| .|..|..| 
gWiekndpelareilnilkvarnsks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP
subfamily_eak_pd Subfamily eak 45-207 4.7e-18 59.7 In-house 39-199 (332) alignment 
Range on Protein: 45-207
Range on HMM: 39-199/332.0
EKIYPTATGEKEENVKKNrYKDILPFDHSRVKLTLKTpSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCE
...     ... |.|..|   .|.|.|.  |.||         ||||  ..     . |. |  .  . |  ||.|. | .   ||.   . |.. .| .
qrllsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFD
.|.|  . . . |  ... . .   |  .  | | |.  ||. |.. ...  | . ..|   |
kyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyed
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 99-286 6.3e-17 56.4 In-house 3-196 (199) alignment 
Range on Protein: 99-286
Range on HMM: 3-196/199.0
GPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN----ESRRLYQFHY
| . |.||| || .|. |||.|.||     |||   .          |||        .. . ....   .. || | .|.|  .      .| . .. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VNWPDHDVPSSF---DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELV
  | ..  |        ..    . .||..  | |. .||| | | || . |.|      .  |     ..|.. . .|  |   . . ..|...
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 100-286 6.6e-17 56.3 In-house 3-195 (198) alignment 
Range on Protein: 100-286
Range on HMM: 3-195/198.0
PKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQN----ESRRLYQFHYV
 . |.||| || .|. |||.|.||     |||   .          |||        .. . ....   .. || | .|.|  .      .| . .. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDHDVPSSF---DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIpEEFNVFNLIQEMRTQRHSAVQTKEQYELV
 | ..  |        ..    . .||..  | |. .||| | | || . |.|      .  |     ..|.. . .|  |   . . ..|...
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 58-147 2.2e-16 54.1 In-house 48-153 (349) alignment 
Range on Protein: 58-147
Range on HMM: 48-153/349.0
NVKKNRYKDILPFDHSRVKLT--LKTPS------------QDSDYINANFIKG--VYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRK
   |||||||||..||||||   ||..             .  ||||||..|   .   | |.||| ||  || ||...|   .| ...    ..| . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCERYW
||..||
kcdiyw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 188-299 1.6e-15 51.7 In-house 216-349 (350) alignment 
Range on Protein: 188-299
Range on HMM: 216-349/350.0
RLYQFHYVNWPDH---DVPSSFDSILD-------MISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWN-LLKAGKIPEEFN-----------VFNL
 .||... ||.|      | |. ..|.              ... .  || .|||||.|||| ....|.  . ..   .. .|..           .. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ
..|.| || | ||...|.  .. |.  .|. ...
vnelrkqrismvqnldqfifiYeallfyfaLrkd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 57-135 7.1e-14 46.0 In-house 95-172 (244) alignment 
Range on Protein: 57-135
Range on HMM: 95-172/244.0
ENVKKNRYKDILPFDHSRVKLTlkTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMA-CRE
.|  |||    |||| .|| |.    |    |||| |.  .     |. || |||.| .|||.|. |  | ..|.    |
nnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 101-185 5e-13 43.2 In-house 236-316 (440) alignment 
Range on Protein: 101-185
Range on HMM: 236-316/440.0
KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACrefEMGRKKCERYWPLYGEdPITFAPFKISCEDEQARTDYFIRTLLLEFQNE
.|..||| ||  ||.||||.. .|..  |.|     ..  | |  |||.     .|| || .     .      .||| | ...|
nafiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykee
subfamily_PTPDC1_pd Subfamily PTPDC1 191-293 9.5e-13 43.0 In-house 84-175 (182) alignment 
Range on Protein: 191-293
Range on HMM: 84-175/182.0
QFHYVNWPDHDVPsSFDSILDMISLMRKYQEHEdvPICIHCSAGCGRTGAICAIDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAI
 .. . |.|..|. | ..|||.. ..    ...   . .|| || |||| . |    ..        ....  . |. .| .| ...||.|| |||.   
yvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvya........krltaekaiklvrskrpksiqtreqvelvkefa

AQL
. |
lfl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 182-295 1.1e-12 42.0 In-house 213-345 (349) alignment 
Range on Protein: 182-295
Range on HMM: 213-345/349.0
FQNESRRLYQFHYVNWPDHDV---PSSF-------DSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKA-----GKIPEEFNV----
 ...   |.|. . ||.|  .   | |.       . ..|       ... .  .. .|||||||||| .. .|.  ..|.       ||  .       
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

FNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE
.  . |.| || | ||   |.  .. |. . | 
siivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_CG42327_pd Subfamily CG42327 221-292 1.1e-12 42.3 In-house 244-313 (319) alignment 
Range on Protein: 221-292
Range on HMM: 244-313/319.0
EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
...  |. .||| | |||| . | | . . |.  |  .  .. .|.. .| .| |||.||||||.... . .
resqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 49-108 5e-12 39.8 In-house 39-95 (95) alignment 
Range on Protein: 49-108
Range on HMM: 39-95/95.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKtpsQDSDYINANFIKGVYGPKAYVATQG
| ..|  | |. |||. .|.|.| .|| || |   .||||||| |. |    ..|.|.||
pytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 52-131 3.6e-11 37.2 In-house 31-115 (347) alignment 
Range on Protein: 52-131
Range on HMM: 31-115/347.0
TGEKEENVKKNRYKDILPFDHSRVKLTLK----TPSQDS-DYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVM
. | | ...||| ||    | .|| |. .    ....|.  ||||  ||     | |. || || .|| |||.|.   .|  .| 
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 68-198 3.8e-10 34.2 In-house 3-122 (130) alignment 
Range on Protein: 68-198
Range on HMM: 3-122/130.0
LPFDHSRVKltlktpsqDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVM-ACREFEmgrkkcERYWPlyGEDPITFAPFKISCED
|.|. ||..        . .||||.|.  .   . |. || |||.| .|||.|. |  | ..|.    | |      . |||    .|. .   .|    
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywp..dsePlewyeediivtl

EQARTDYFIRTLLLEFQNESRR----LYQFHYVNWP
 .     .|..  || ...  .    |  |.  |||
tdrdefknikasnleiesdlneshqaltmfqisnwp
PTEN_1 175-285 3.5e-09 31.8 In-house 71-184 (196) alignment 
Range on Protein: 175-285
Range on HMM: 71-184/196.0
IRTLLLEFQN---------ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE-DVPICIHCSAGCGRTGAICAIdytwNLLKAGKipeeFNVFN
. .| .|. .         . .. .... . ..|| .||    .    |..  .....    . .|| || ||.| ..|      |...||    ... .
vvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk....ltade

LIQEMRTQR-HSAVQTKEQYEL
 .. .| .| . |... .| .|
AlelvrekRppgapnspsqerl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 46-130 1.7e-08 28.3 In-house 22-105 (332) alignment 
Range on Protein: 46-130
Range on HMM: 22-105/332.0
KIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTpsQDSDYINANFIKGVYGPKAYVATQGPLAN-TVIDFWRMIWEYNVVIIV
  || .  .  .|.  ||   .  ||||||.|. .      |. ||... |     ||. .| |. . |   ||||. | .  .|.
mtypntydkflnnmdmnriphlycfdhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmil
0038934 (Phosphotyrosine protein) phosphatases II 191-291 3.1e-08 29.0 In-house 81-174 (194) alignment 
Range on Protein: 191-291
Range on HMM: 81-174/194.0
QFHYVNWPDHDVPSSFDSILDMISLMRKY-QEHEDVPICIHCSAGCGRTGAICAIDYTWNllkagkipEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA
...   .||. .. |.. .|. ..|. .. .|...  . .|| || |||| ..|                ...   |. .|  | .|... ...| ... 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdyleallkr

IA
  
yk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 229-292 3.3e-08 27.8 In-house 2-62 (69) alignment 
Range on Protein: 229-292
Range on HMM: 2-62/69.0
IHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
.|||.| ||||.  ||      .|. |.    ..|| .| ||  |   |  ...| ..| |...
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 228-292 4.8e-08 27.3 In-house 2-63 (69) alignment 
Range on Protein: 228-292
Range on HMM: 2-63/69.0
CIHCSAGCGRTGAICAIDYTWNLLKAGKIpeeFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ
 .|||.| ||||.. ||      .|. |.    ..|| .| ||  |   |  . .| ..| |...
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_PTEN_pd Subfamily PTEN 173-285 5.4e-08 28.0 In-house 62-171 (184) alignment 
Range on Protein: 173-285
Range on HMM: 62-171/184.0
YFIRTLLLEFQNESRRLY-QFHYVNWPDHDvPSSFDSILDMISLMRKYQEHEDV-PICIHCSAGCGRTGAICAIdYtwnLLKAGKIPEEFNVFNLIQEMR
| |  |  | . .|...  . . ..  ||  | ... . .... ..|. |...   . .|| || |||| . .  |   |||....... .. .| .|.|
ykiynlrserkydskkfdgrvavypfdDhn.ppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva.y...llkslllekaeealelfaeaR

TQRHSAVQTKEQYEL
|. ...|.   |   
tknkkgvtiPsqrRY
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 49-97 6.5e-08 26.3 In-house 38-86 (440) alignment 
Range on Protein: 49-97
Range on HMM: 38-86/440.0
PTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGV
|.      .|  ||||..|| .||||| |       ||||||| .|.|.
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 178-287 3.8e-07 23.0 In-house 196-302 (346) alignment 
Range on Protein: 178-287
Range on HMM: 196-302/346.0
LLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPeefNVFNLIQEMRTQRHSAV
.| | . .|      |.  |   . |     |. ||  .   .. ... .|.    ||||. ..    |. | |  |  |   |......... ||  .|
vlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiep...niceimknikqqrpggv

QTKEQYELVH
..  ||  ..
esfaqyasiy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 57-97 4e-07 23.9 In-house 38-77 (244) alignment 
Range on Protein: 57-97
Range on HMM: 38-77/244.0
ENVKKNRYKDILPFDHSRVKLTLkTPSQDSDYINANFIKGV
 |. |||| .|||||..|| |.  .  . |||||||.|.| 
anatknryinilpfdetrvilss.skkegsdyinanyiqgs
subfamily_DSP23_pd Subfamily DSP23 192-288 4.9e-07 24.5 In-house 54-140 (148) alignment 
Range on Protein: 192-288
Range on HMM: 54-140/148.0
FHYVNWPDHdVPSSFDSILDMISLMRKYQEHEDVpICIHCSAGCGRTGAICAIdYtwnLLKAGKIpeefNVFNLIQEMRTQRHSAVQTKEQYELVHR
.. .. .|.  | . . . ... .. . .|...  . .||  | ||||.. |  |   |.|  |.       . | |.| .|  .|.| || .||. 
lvrlriddy.hppaleqvvefvrvveeaeeknea.vsvhcllgrgrtgtmlac.y...lvkerkl....aaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 54-131 2e-06 20.9 In-house 23-73 (169) alignment 
Range on Protein: 54-131
Range on HMM: 23-73/169.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINAnfikgvygpkayvatqgplantvidfwRMIWEYNVVIIVM
|   |  |||    |   | ||||        ||||||                           ||||| |  .||.
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 54-131 2.4e-06 20.5 In-house 22-72 (169) alignment 
Range on Protein: 54-131
Range on HMM: 22-72/169.0
EKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINAnfikgvygpkayvatqgplantvidfwRMIWEYNVVIIVM
|   |  |||    |   | ||||        ||||||                           ||||| |  .||.
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv
subfamily_eak_pd Subfamily eak 212-294 6.3e-06 19.8 In-house 223-305 (332) alignment 
Range on Protein: 212-294
Range on HMM: 223-305/332.0
MISLMRKYQEHE--DVPIcIHCSAGCGRTGAICAIDYTWNLLKaGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLF
. |...||.       || | .. |  |.|.   ||   .|.  .|. . . | .||  ....|  .| .. |. ... .. . .
lsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_VSP_pd Subfamily VSP 192-294 7e-06 20.1 In-house 96-198 (212) alignment 
Range on Protein: 192-294
Range on HMM: 96-198/212.0
FHYVNWPDHDVPSsFDSILDMISLMRKYQEHED-VPICIHCSAGCGRTGA-ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRa
 . ..  ||.||. .. .| .   .... |..    . |||  | ||||. .||.  . ....  |   ..      .. .....  |||  |.  |.  
vkriliddhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgy.

IAQLF
..|..
leqvk