Gene PTPN18 in Homo sapiens

Synonym: BDP1, PTP-HSCF, PTPN18

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP073_AA protein Get Run
HsapP073_AA_8-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 24-299 1.2e-129 426.3 In-house 8-284 (290) alignment
Range on Protein: 24-299
Range on HMM: 8-284/290.0
AVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFG
. .| ||......|...||. |.|| ||...|||.||||||.||||..|| ||  .|| .|||||.|||.||.|.|.|||.|||||.|| ||||..||. 
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

VKVILMACREIENGRKRCERYWAQE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP
|....|||||.|.|.|.|||||..| .|.|..| |..||..||....|...|||||..|||||.|||..|..|||.|||||....|...|..|.|| |  
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesed

EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
.||.||||||.||||.....||||.|| ...||.....||.||..||||.|.|||.|||...|..||......|.. 
aPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii

0051299 (Phosphotyrosine protein) phosphatases II 9-290 1.3e-89 295.8 In-house 8-284 (288) alignment
Range on Protein: 9-290
Range on HMM: 8-284/288.0
RSFLERLEARGGREGAVLAGEFSDIQACSAAwkadgvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPL
...|......  .  . |. || ..... .       ... |...|||. ||||.|.||||..||.|| |.....||||| ..|.| . . ..|||||||
eellklvlkllangltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPS
|.|. ||||.||| .|.|| | ....|.||. |..|| . ...|. | ...||..|.  ..|...|||.||      ...||| |....|..||| |||.
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
||...|......|. . ||. | .||||||.||||.....|.. ..|...     ......| ..|.||| .|||.|||||.|.... 
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0050432 (Phosphotyrosine protein) phosphatases II 27-293 3e-89 294.7 In-house 45-300 (308) alignment
Range on Protein: 27-293
Range on HMM: 45-300/308.0
AGEFSDIQACSAawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqeEGHSDYINGNFIRGV--DGSLAYIATQGPLPHTLLDFWRLVWEFGV
  || .....        .... ....|||. ||||||.||||..||.|     ...||||| ....|   . . ..||||||||.|. ||||.||| .|
eeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

KVILMACREIENGRKRCERYWAQE--QEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgs
.|| | ....||||. |..||  |  ...|. | |..||..|.. ..|...|||..|.   .||| |....|..||| |||.||...|...|..|. .  
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
...| .||||||.||||.....|.. ..| ..     ...|..| |.|.||| .|||.|||.|||.... .. 
pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0046845 (Phosphotyrosine protein) phosphatases II 41-294 9e-89 292.9 In-house 13-276 (284) alignment
Range on Protein: 41-294
Range on HMM: 13-276/284.0
KADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGV-----DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREI
. . ..|. .. .|||. ||||||.||||..||.|. |... ..||||| ....|      . . ..||||||||.|. ||||.||| .|.|| | ....
tvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelv

ENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHC
||||. |..|| .|.|.|. | |..||..|.. ..|...|||..|.    .||| |....|.||||.|||.||...|......|.|.   .|..| .|||
engrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

SAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
|||.||||.....|.. ..| .. ..  ......| ..|.||| .|||.|||||.|.... .. .
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0036941 (Phosphotyrosine protein) phosphatases II 42-296 4.6e-87 287.4 In-house 25-281 (297) alignment
Range on Protein: 42-296
Range on HMM: 25-281/297.0
ADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRC
    .|. ....|||. ||||||.||||.|||.|    ....|||||.... | | . ..||||||||.|. ||||.||| .|.||.| ....|.||. |
llllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

ERYWAQE-QEPLQTGLFCITLIKEKW-LNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGR
..||  | .|.|. | | .||....  |..|. ||||.||.   .||| |....|..||| |||.||...|...|..|. .    ...| .||||||.||
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTL
.|.....|.. |.| .... . ......|.|.|.||| ||||.|||||||..... . ..|
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0040438 (Phosphotyrosine protein) phosphatases II 45-296 1.9e-86 285.5 In-house 32-282 (317) alignment
Range on Protein: 45-296
Range on HMM: 32-282/317.0
VCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
....  ...|||  ||||.|.||||..||.|| |..  .||||| ... | . . ..||||||||.|. ||||.||| ||.||.| ... |.||. |..|
ldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqY

WAQeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
| . .|.|. | |..||..|.. ...| ||||.|.    .||| |....|..||| |||.|||..|...|..|. . ....|..||||||.||||.....
wpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaa

DYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC--STL
... ..| . .   .......| ..|.||| ||||.|||||||  .....    ||
ylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl

0045450 (Phosphotyrosine protein) phosphatases II 31-291 4.4e-85 281.4 In-house 34-303 (307) alignment
Range on Protein: 31-291
Range on HMM: 34-303/307.0
SDIQACSAAWkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFI--------RGVDGSLAYIATQGPLPHTLLDFWRLVWE
 ... .   .    .... ....|||  ||||||.||||.|||.|| |... ..|||||....         | | ....||||||||.|. ||||..||
ekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

FGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
 ||.||.| ....|.||. | .|| .|.|.|. | |..||..|.   ... .|||.||   . .||| |....| .||| |||.|....|...||.|. .
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

GS--GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
..  ...| .||||||.||||.... ... ..| .. . .|..|...| ..|.||| |||..|||||||. ... 
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0047943 (Phosphotyrosine protein) phosphatases II 26-289 2.8e-84 278.1 In-house 14-269 (273) alignment
Range on Protein: 26-289
Range on HMM: 14-269/273.0
LAGEFSDIQACSAawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVK
|. || ... .        .... ....|||  ||||||.||||..||.|    ..|.||||| ....| . . ..||||||||.|. ||||.||| .|.
lleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

VILMACREIENGRKRCERYWAQEQE--PLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS-
|| | ....|.||. |..|| .|..  .|. | |..||..|.. ..|...|||..|.   .||| |....|..||| |||.|....| ..|..|. . . 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 ...| .||||||.||||.....|.. ..| .      ......| ..|.||| .|||.|||||||....
psngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyeall

DSPc_SM00195 47-292 1.5e-83 275.5 In-house 17-262 (263) alignment
Range on Protein: 47-292
Range on HMM: 17-262/263.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
.|  . ...|..|||||..||||.|||.|.  ... .||||| |.|.| . . .|||||||||.|. ||||.||| .||.|.| ..| |||...|.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

QE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVD
.| ... . | . ..|....  ...| ||||..|...  |.|.|.|.|| .|||.|||.|....|.......  . .  .|..||||||.||||...|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

YVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.. . | ..     ...|..| ..||||| .|||.|||.|.|.......
iilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 47-292 1.5e-83 275.5 In-house 17-262 (263) alignment
Range on Protein: 47-292
Range on HMM: 17-262/263.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
.|  . ...|..|||||..||||.|||.|.  ... .||||| |.|.| . . .|||||||||.|. ||||.||| .||.|.| ..| |||...|.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

QE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVD
.| ... . | . ..|....  ...| ||||..|...  |.|.|.|.|| .|||.|||.|....|.......  . .  .|..||||||.||||...|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

YVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.. . | ..     ...|..| ..||||| .|||.|||.|.|.......
iilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0039614 (Phosphotyrosine protein) phosphatases II 27-292 1.7e-82 272.6 In-house 35-289 (297) alignment
Range on Protein: 27-292
Range on HMM: 35-289/297.0
AGEFSDIQACSAawkadgvcSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGVDG-SLAYIATQGPLPHTLLDFWRLVWEFGV
  || ... .          ... . .|||. ||||||.||||..||.|. . .   .||||| ... | |  . ..||||||||.|. ||||.||| ||
llefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

KVILMACREIENGRkRCERYWAQEQEplQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GP
.||.| ....|.||  |..|| .|..  . | |..||.|..  ......|||.||  .||| |...||..||| |||.|....| ..|..|. . .  ..
tvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.| .||||||.||||.... ... ..| .     .......| ..|.||| ||||..||||||. .....
gpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell

0043336 (Phosphotyrosine protein) phosphatases II 10-289 7.6e-82 270.2 In-house 6-274 (278) alignment
Range on Protein: 10-289
Range on HMM: 6-274/278.0
SFLERLEARGGREGAVLAGEFSDIQACSAawkadgvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLP
..|..|. ..  . ..|  || ... .         ...  . .|||. ||||||.||||..||.||||... .||||| ... | . . ..||||||||
dllkallelllnlktllllefeellsfkl.......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlp

HTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAqeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHM
.|. ||||.||| ||..|.| ... |.||. | .||   ...|. | | .||.||.  ..|...|||.||    .||| |....|..||| |||.|....
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

LAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
| .....|. . . ..|..||||||.||||........ ..| .      ..|...| ..|.||| ||||..||||||. ..
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_PTPRD_pd Subfamily PTPRD 48-294 7.2e-81 267.5 In-house 40-283 (564) alignment
Range on Protein: 48-294
Range on HMM: 40-283/564.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
. | . |.| .||||.....||..||.|| .. .  ||||| .|| | . . |||||||||..|. ||||.|||  ...| |  .  |.|...|..|| .
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

EQePLQTGLFCITLIKEKWLnEDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYV
.. . . | . .|| .|. | .|...||.|.  . ..||| | | ...||||.||| |. ..|..... |.|. .. .|. |||||| ||||. ...|..
kg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividam

RQLLLTqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
 . . .     .  .. .| ..||||.| ||||||| |........  .
lerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

0045098 (Phosphotyrosine protein) phosphatases II 50-292 3.2e-77 254.9 In-house 27-272 (278) alignment
Range on Protein: 50-292
Range on HMM: 27-272/278.0
AGSRPENVRKNRYKDVLPYDQTRVIlsllqeeghsDYINGNFIRGVdgSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQ
 . ...|. ||||||.||||..||.          |||| ..|.|   . ..||||||||.|. ||||..|| |..||.|.....|.||. |..||   .
palylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.g

EPLQTGLFCITLIKEKWLnEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPSSP--DHMLAMVEEARRLQG-------------SGPEPLCVH
..|. | |..||..|..| .|. ||||.||         ||| |..|.|..||| ||||.|  ...| ..|. |. .              ....|  ||
gsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGCGRTGVLCTVDYVRQLLltqmiPPDFSLFDVVLKMRKQRPA-AVQTEEQYRFLYHTVAQMF
||||.||||.|. ......||     .. ..|...| ..|.|||  |||..|||||||. .....
CsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell

0040439 (Phosphotyrosine protein) phosphatases II 48-291 5.6e-77 254.0 In-house 3-245 (249) alignment
Range on Protein: 48-291
Range on HMM: 3-245/249.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
.  ...|||. ||||.|.||||..||.|| |..  .||||| ..| | . . ..||||||||.|. ||||..|| |..||.|.... |.||. |..|| .
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGRTGVLCTVD
 ...|. | | .||..... ..|...|||..|    .||| |...|| .||| |||.|....|...|..|  . .   ..|..||||||.||||.... .
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

YVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.. ..| .     ...|...| ..|.||| |||..|||||||  ... 
lmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallel

Y_phosphatase Protein-tyrosine phosphatase 56-289 3.8e-76 251.0 Pfam-A 1-234 (235) alignment
Range on Protein: 56-289
Range on HMM: 1-234/235.0
NVRKNRYKDVLPYDQTRVILslLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQT
| .||||||.||||.||| |   ..||.||||| |...| . . ..|||||||..|. ||||.||.  |||| | ... |.||. |..||  .|.|.|..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GLFCITLI-KEKWLNEDIMLRTLKVTFQKES---RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLL
| ....|  |||  .....||.|... .||.   |.|.||.| .|||.|||.||...| .... .. . .  .|..||||||.||||.....|.. . | 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
..     ......| ..||||| .||..||| |||....
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 56-289 3.8e-76 251.0 In-house 1-234 (235) alignment
Range on Protein: 56-289
Range on HMM: 1-234/235.0
NVRKNRYKDVLPYDQTRVILslLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQT
| .||||||.||||.||| |   ..||.||||| |...| . . ..|||||||..|. ||||.||.  |||| | ... |.||. |..||  .|.|.|..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GLFCITLI-KEKWLNEDIMLRTLKVTFQKES---RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLL
| ....|  |||  .....||.|... .||.   |.|.||.| .|||.|||.||...| .... .. . .  .|..||||||.||||.....|.. . | 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
..     ......| ..||||| .||..||| |||....
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 52-290 1.5e-75 249.0 In-house 5-241 (245) alignment
Range on Protein: 52-290
Range on HMM: 5-241/245.0
SRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQEP
..|||. ||||.|.||||.|||.||  ... .||||| ... | . .  .||||||||.|. ||||..|| |...|.| ..| |.||. |..|| . .|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

LQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG-SGPEPLCVHCSAGCGRTGVLCTVDYVRQL
|..| |..||..|.. ..|...|||.||    .||| |....|..||| |||......| ..|..|. .  ....|..||||||.||||........ ..
ltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
| . .   ..||...| ..|.||| ||||..||||||. ...
lekel...gvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 45-308 4.2e-75 247.7 In-house 36-298 (318) alignment
Range on Protein: 45-308
Range on HMM: 36-298/318.0
VCSTVAgSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
| |. .   | | .|||| ..|.||.||| |. |..|  ||||| |.| |   . ||||.|.|||.|. ||||.||| . .||.|  .| |.|.....||
vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WAQEQePLQTGLFCITLIKEKWLnEDIMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ-GSGPEPLCVHCSAGCGRTGVLCT
| ... . . |   ..| .|. | .| .||..||| .  .||| | | .| ||||.|||.|. ..|..| .... |  || .|. |||||| ||||| ..
WPskg.srsygklvvelkeevel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfia

VDYVRQLLL-TQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS--TLQNASPHYQNIKE
|| . . .   ...     .|..| ..|.||.. ||||.|| |.|... ..  |  |  .||   ..|.|
vdillerikaealv....Dvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

0037934 (Phosphotyrosine protein) phosphatases II 51-291 2.1e-73 242.2 In-house 5-241 (243) alignment
Range on Protein: 51-291
Range on HMM: 5-241/243.0
GSRPENVRKNRYKDVLPYDQTRVILsllqeEGhSDYINGNFIRGVDGslaYIATQGPLPHTLLD----FWRLVWEFGVKVILMACREIENGRKRCERYWA
...|||. ||||.|.||||..||.|     || |||||.|.|.....   .||||||||.|. |    |||..|| |..||.| ....|.||. |..|| 
allpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

qeQEPlQTGLFCITLIKEKWLnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRL--------QGSGPEPLCVHCSAGCGR
  .|  . | |..||..|..| .|...|||...    ....| |....|..||| |||.||...|....|.|          . .. .|..||||||.||
..gev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVLCTVDYVRQLLltqmippDFSLFDVVLKMRKQRPA-AVQTEEQYRFLYHTVAQM
||.|.. ... .||       ...|...| ..|.|||  ||||..||||||. ....
tGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPRB_pd Subfamily PTPRB 47-295 4.2e-73 240.9 In-house 42-288 (293) alignment
Range on Protein: 47-295
Range on HMM: 42-288/293.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
...| ....|  ||||...||||..|| |. |..| .||||| |.|.|      .||||||||.|. ||||.|||  ...|.|  . .|.|...||.|| 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

QEQEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ--GSGPEPLCVHCSAGCGRTGVLCTVDY
...|| . |   .||..|. | || ..|.||.. .||.|.| |....|||| |||.... .|..|.. |. .   .  .|. |||||| ||||.. ..| 
adeepvlyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

VRQLLLTqmipPD-FSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
. | . .     |   .| .| ..|..|   ||||.|| |....| ... ..
llqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_PTPN6_pd Subfamily PTPN6 27-291 2.5e-72 238.5 In-house 29-296 (306) alignment
Range on Protein: 27-291
Range on HMM: 29-296/306.0
AGEFSDIQACSaawkADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSlLQEEGHSDYINGNFIRG--VDGSLAYIATQGPLPHTLLDFWRLVWEFGV
  || ..|       |  . |   |..||| .||||| .||.|.|||||.  ..   |||||.|.|..   . . .|||||| |..|. ||||.||.   
eeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

KVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKV---TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSG
.||.|. .|.| |...| ||| .|.|  ..|   .| ..||  ..| .||.|.|   ...||.|.|.|... |||| |||..|...|...|. .| | . 
rvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks.ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

----PEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
    . |..|||||| |||| .  .| . .|. .. .  |. . ..| ..|.||   ||||.||.|.|..... 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 47-292 2.4e-70 231.8 In-house 32-276 (281) alignment
Range on Protein: 47-292
Range on HMM: 32-276/281.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
...|  ..||| ||||...  ||.||| ..  .|. ..|||| ||. |..|  .|||||||.|..| .||..|||  |..| |  ||||.|. .| ||| 
tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP

QEQEPLQTGLFCITLIKEKWlNEDIMLRTLKV-TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDY
.... |. | . .. ..|.  ..  . |..|. . . |.|.| ||.|..||| |||... ..|   .| ..|. .    ||..||||| ||||.  ..| 
ddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr

VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
. . . ...  .. .. .|| ..||.|   |||  ||.|.|..| ...
lvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_PTPN3_pd Subfamily PTPN3 49-292 7.5e-70 230.0 In-house 34-275 (280) alignment
Range on Protein: 49-292
Range on HMM: 34-275/280.0
VAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIR----GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
 |  .|||. ||||.|.||||.|||.|    .|...|||| |..     . . .  ||||||||..|  |||..|||  ...|.|    .|.||..| .|
saarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WAQEQEPLQTGLFCITLIKEkWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
| .... |. | | ... ||   .. ..|| | .. ..  |.|.. ||||..||| |||......| .||. |.|. .  ||. |||||| |||||| ..
WPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DYVRQllLTQMIpPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.   .  |...   ..   |.| .|| || . |||..||.|. ... ...
etala..lieaa.epvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 47-292 4.4e-67 221.1 In-house 38-279 (288) alignment
Range on Protein: 47-292
Range on HMM: 38-279/288.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
|. ||....| .||||...||||..|| |  |.||  .|||| ..| | ... .||||||||..|. |||.||.|  .. |.|    .|.|...||.|| 
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP

QEQEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVR
....| . | . .||...| | ||..||.| .  .|. . . |.||..||| ||| |   .|....     . .  .|. |||||| ||||.  ..| . 
dadkpknyGsvtvtlveskel.edfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

QLLLTqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
. . .        ....| |.||||.  |||..|| |.|...... 
davee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_PTPN13_pd Subfamily PTPN13 48-291 9.3e-66 216.9 In-house 29-268 (273) alignment
Range on Protein: 48-291
Range on HMM: 29-268/273.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSllqEEGHsdYINGNFIRGV--DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYW
.  | . || .||||..|||||.|||.|.   .||   ||| ..|.    .    |||.|||||.|  |||..|||  ..|| |   | |.|. .|.|||
cevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

AQEQ-EPLQTGL-FCITLIKEKWLnEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsGPEPLCVHCSAGCGRTGVLCT
 ... ..|.    . ..|.| . | ..  .|.|.|.    .||| | .|....||| |||||....| .| | ||||     |. |||||| ||.|.| |
Pesknkklkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

VDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.| | .|.  .    .| . ..| |.|.|| . |||..|| | |... ..
idvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN9_pd Subfamily PTPN9 51-289 3.9e-65 214.8 In-house 37-287 (297) alignment
Range on Protein: 51-289
Range on HMM: 37-287/297.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-Q
   . |..||||.||| ||.||| |. ..|. .||||| ||. |     |.|||||||..|  ||||.|||  | ||.|. | .|.|| .| .|| .| .
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

EPLQTGLFCITLIKEKwLNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSG-------------PEPLCVHCSAGCG
.  . | . .. .. .  .|| . |.|...   ..|||.|   |..|||| |||||   .| ..|..|. |..                |. |||||| |
ssaefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RTGVLCTVDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
||| ..|.|.  . | ..       ....| ..|.||  ..||.||| | | .| 
rtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 25-292 8.4e-65 213.9 In-house 24-283 (319) alignment
Range on Protein: 25-292
Range on HMM: 24-283/319.0
VLAGEFSDIQACSAAwkadgvcSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGV
 |. || ...  ..        ..   |..|| .||||...|.||.|||.|| |..   ||||| .|| | .   ..||||.|| .|. ||||.||| ..
llekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

KVILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWLNeDIMLRTLKV---TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG-S
 ...| ..  |... ....|| . ... . | . .|| .|. |. |.. | ||.   . . |.|.| . ||..||| .|| .   .|..... |. .  .
sivvmltklveklkvklkkywpe.enfeeyGrlivtleeeeele.dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
   |. |||||| ||||  ...| . . . . ...     .| .| ..| ||.  ||..|||.|.|... .. 
qsgPivvhCsaGvGRtGtfivldamlervkeegvl....DvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_PTPRG_pd Subfamily PTPRG 27-315 2.4e-64 212.5 In-house 22-310 (563) alignment
Range on Protein: 27-315
Range on HMM: 22-310/563.0
AGEFSDIQACSAAWKADgvcsTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVK
. || ..| .... . |    . . ..||| ||||| ....||..|| || | .. .. |||| |.| |   | |.|||||||..|. ||||..||  |.
seefealqsetiskdld....aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

VILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWL----NEDIMLRTLKVTFQKE---SRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
.| |     |.||. |..|| . .|... | . .|||.|. |     . .... ||.  .|.    . |.| .| .||| |||...   | .|. . . .
iivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

GSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYD
 .   |. |||||| ||||... .| . . . .. .     .|... ..| ||.  ||||||| ||. .. ..  |  .. . .  .  .||.|  .
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 56-294 1e-62 206.6 In-house 20-265 (270) alignment
Range on Protein: 56-294
Range on HMM: 20-265/270.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP-LQ
. . |||.|.||  .|||.|. |.|. .. ||| |..||.||.  .|||..|||| || .|||..||  |. |.|.    |.|||.|||||..|..  ..
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

TGLFCITLIKEK-WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPD------HMLAMVEEARRLQGSG--PEPLCVHCSAGCGRTGVLCTVDY
.    |. ....   .|  .|. |... . |.| .   .| .|||.|||...|      ..|.|... || . .    ||| |||||| ||||.| ..|.
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

VRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQmFCS
. .|| ...      .  .. ..||.|.| ||. |||.|||..|.. ...
avrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavve.yae

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 21-293 3.2e-62 205.4 In-house 24-291 (298) alignment
Range on Protein: 21-293
Range on HMM: 24-291/298.0
REGAVLAGEFSDIQACSAAWKADgvCSTvAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
 . ...| ||  ... |   ...  ... ....||| .|||| |....|..||.|.  ... .|||||  |. . .|. |.||||.||..|. ||||.|.
kkltgyalefqrlnsvsseieee..eke.varkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EFGVKVILMACREIENGRKRCERYWAQEQEpLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
|  ...| |     | .. ....|| .|..  . | . ..| ...    |.. |.|||. .|  ..|.| ||...||||.|||.    .|..... |. |
eedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasq

-GSGPEPLCVHCSAGCGRTGVLCTVDYVR-QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
  .| .|. |.|||| ||.|  . .| |  ..   |..     .|.||  .||.||.|||||||| |.|. | ... 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv....DvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 51-294 3.5e-62 205.3 In-house 41-285 (305) alignment
Range on Protein: 51-294
Range on HMM: 41-285/305.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQ-
|.. .|..|||.|.. ..|. |.||.  .....||||| ... | ... .||..||||..|. |||||..|. |..|.| .. .|.|...|..||.... 
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

EPLQTGLFCITLIKEKWLNeDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPE-PLCVHCSAGCGRTGVLCTVDYV
|. . | | ..|  ||  . | . | ||...   .||||.| |.|  .||| ||| ..  .| .... .. | .. . || |||||| ||||| ..||  
ekkefgefsvelksektas.dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

RQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
 . | .  .     .|.|. ..|..|. .||| .|| ||.  ....  .
lerlkkEev...vdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

subfamily_PTPRA_pd Subfamily PTPRA 44-306 8.1e-62 204.0 In-house 48-314 (330) alignment
Range on Protein: 44-306
Range on HMM: 48-314/330.0
GVCStvAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCER
...   . |. || .|||. ..|||| .||||| .. . .|||||  || |      .||.|||. .|. ||||..||.    |.|     |  ...|..
atle..laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWAQeQEPLQTGLFCITlIKEKWLNEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTG
|| . .  .  |   .. .... . .|. .| . |.       .|.|| | |. . |||| |||. |  || .... ..|.    .|. |||||| ||||
ywPd.eGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

VLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM--FCST-LQNAS--PHYQNI
 ....| | . . .. .     .|..| ..|.|||  |||.||| |.|... .   .  | |. .|   | |..
tfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkl

subfamily_Ptp69D_pd Subfamily Ptp69D 47-293 1.1e-61 203.6 In-house 39-287 (307) alignment
Range on Protein: 47-293
Range on HMM: 39-287/307.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
||... . ||  ||||.|. ..|.|||.|. .. . .||||| .||.| . .  .|| |.|.  |. ||||...|  |..| |   . |  ||.|..||.
stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWp

QEqEPLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK-------ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVL
.| .  | |   ..|..|.   .| . |.|.|. .|       .|| | | .|..|.|  || ..  .| ..|..| |.     |. |||||| ||.|..
ie.devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif

CTVDYvrqLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 ..|    ||  .      ..|..| ..|.||.  ||  ||| |||. ....  
valds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 53-294 2.7e-61 202.2 In-house 46-282 (315) alignment
Range on Protein: 53-294
Range on HMM: 46-282/315.0
RPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEqePL
. ||..|||| ....||..|| | ||. . ||||.| ||| | .    |||.|||.. .. ||||||.|  .  |.|    .|. ....|.||  .   .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kv

QTGLFCITLIKEKwLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  | . .|...|.  |...  ||| |.|... | |.||.| |||| ||| .   .. ..  ... . .   .. |||||| |||| ..|.| | . . ..
iyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

mipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF-CS
       ..... ..|..|  .||. |||.|.| .. . | | 
...naidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 54-290 3.8e-60 198.4 In-house 41-274 (515) alignment
Range on Protein: 54-290
Range on HMM: 41-274/515.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPL
  | .|||||..||||..||.| ..... ||||.|  .|...|   ||||.|||.. .. ||||||..  |  | |  .  |. . .| .|| .   . .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLT
. | . . |.  .    . . |.|.|. ...|| | | ..  |||.|||     .| .. | .  .|    || .||||| |||||....|  | .   |
kfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahaktt

QMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
.|.     .|..| ..|..||  |||.||| |.| .| .
rmv....dvfnfvtnirqkrpylvqtqeqyafiygavle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 47-291 6.8e-60 197.5 In-house 35-276 (315) alignment
Range on Protein: 47-291
Range on HMM: 35-276/315.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
 . ..  ..| .|||||..||.|..||.| ..... .|||||  .|..||   ||||.||||. .. ||||.|..  |  | |     |. . .| .|| 
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

Q-EQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-
. . .  . | . ..|.. .  . | . | | .   .||| | | |.  |||.||.     .| .. | .  .|.   .| |||||| |||||....|  
drkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

VRQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
| |.  |...     .|..| ..|..||  |||||.| |.| .| . 
vaqikrtrsv....dvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 51-293 2.5e-59 195.5 In-house 4-243 (250) alignment
Range on Protein: 51-293
Range on HMM: 4-243/250.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKrCERYWAQEQe
. .|.|  |||| |....|..||.|   . . .|||||  |. | |.. |.|||||||..|. ||||.|.|  ...|.|     |.... ...||  |. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.

PLQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRS--VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS-GPEPLCVHCSAGCGRTGVLCTVDYVR-
. . |   ..| ...    |.. |.||.. .|.. .  | ||....|||.|||     .|..... .. |   |  |. |.|||| ||.|  ...| |  
aekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
.|   ...     .|.|. ..||.|| ||...||| |.|. . ..  
rlkkekvv....dvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPRK_pd Subfamily PTPRK 53-293 4.6e-59 194.8 In-house 40-279 (314) alignment
Range on Protein: 53-293
Range on HMM: 40-279/314.0
RPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPl
. || .|||..|.|.||..||.|  .... .|||||...| .   . |.|.|||||..|. ||||||.. .   |.|    .|.|| .| .|| .. |  
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

qTGLFCITLIKEKwLNEDIMLRTLKVTF----QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQL
  | . ..|.. . |..... |...|.     |.| | | |.|...||| .|| |   .|..| .    |  .  .. ||||||.||||. ...| | ..
.ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm

LLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ-MFC
. .. .     .| .| ..|....  |.|||||.|.|  . .  .|
ieregv...vdvfnavktlrsrkvnmveteeqykfiydvileaclc

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 55-291 6e-58 191.1 In-house 27-267 (274) alignment
Range on Protein: 55-291
Range on HMM: 27-267/274.0
ENVRKNRYKDVLPYDQTRVILSLLQE-EGHSDYINGNFIRGVDG-SLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP-
 . .|||||..|| ...||.|.  .  .  |.||| |.|.| |. | ||.|||||||.|. ||||....  |.||.|  .  |. ...|..|. ....  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

LQTGLFCITLI-KEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ---GSGPEPLCVHCSAGCGRTGVLCTVD-YVR
..     . .  ...  ..|  .|.| .  ....|||.   | .|||. .| .....| .|.| .. .        |  |||||| ||||.  ...  ||
iserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
||  ....     .. .| ..| .|   |||.|||......... 
qlreeivv....dvlkivcnlrldrGGmvqtseqyelihralcly

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 42-295 1.6e-56 186.8 In-house 35-291 (325) alignment
Range on Protein: 42-295
Range on HMM: 35-291/325.0
ADGVCSTVAGsRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAcREIENGRKRC
 ||.  .||. .|||. |||.|.|...|..||.|  ......||||| ...|   .   ..|.| ||..|. |.|||| ..   |...   |...| .||
ddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrc

ERYWAQE-QEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKE--SRSVYQLQYMSWPDRGVPSSPDHML------AMVEEARRLQGSGPEPLCVHCSAG
  || .|  .  . | . . |.  . .  | . | |.|   |.  .||| |.|..||.| ||.  |  ..        |.|  . .  .  |. ||||||
avywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

CGRTGVLCTVDYVrqllLTQMIP-PDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
 |||||. ..  .    | ..|      .|..| |.||.||. |.| .|| ..|....... | 
vGrtGvfislysa....lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 47-294 4.2e-56 185.2 In-house 43-286 (297) alignment
Range on Protein: 47-294
Range on HMM: 43-286/297.0
STVAGSRpENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACrEIENGRKRCERYWA
.|||  .  |  |.|||..||||. ||.|  ....  |||.|  |..|.     .|.|| | . |. |||..|..  |..|.|   . ... |.| |||.
qtvaekk.vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln.ddnerdkkcaryWs

QEQEpLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPS--SPDHMLAMVEEARRLQGSGPE-PLCVHCSAGCGRTGVLCT
..    . |   ..|   .   |  . |.|.|| .|    | | | |...|||. |.   |   .| ...| |   ..  | || |||.|| ||||||.|
dkgv.ttfGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

VDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
.| |      .    .  .|..| |.|..||  |||.|||.|.| .| ... |
idsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_PTPN23_pd Subfamily PTPN23 55-290 4.2e-56 184.9 In-house 42-278 (288) alignment
Range on Protein: 55-290
Range on HMM: 42-278/288.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGV-DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPL
 .. |||..|.||||..|| |     ... ||||  |....  |.  .||||.||. || |||..|.|  ..|| |   . | |.....||| ..  |. 
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

QTGLFCITLIKEKWLNEdIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARR----LQGSGPEPLCVHCSAGCGRTGVLCTVDYVR
. | . .|| ... ...  . |.||.....  . .||  ||..|||. |||.||...|....|..      |     || |||||| |||||.. |  . 
kfgdlsvtlksvretet.hvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

QLLLTQMIPPdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
. | .. . .   . .|| ..|.||   ||..||..|.|. | .
relekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_PTPN14_pd Subfamily PTPN14 41-292 7.1e-56 184.4 In-house 36-296 (300) alignment
Range on Protein: 41-292
Range on HMM: 36-296/300.0
KADGVCSTvaGSRPENVRKNRYKDVLPYDQTRVILSLLQEEgHSDYINGNFIRGVDGS--LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGR
..|...||  .. |||..|||.||||||...|| ||  .|. ...|||   |. . |.  . ||..||||..|. |||..||| ||..|.|  .|.|.|.
redallst..aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

KRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVT----FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEA---RRLQGSGP------EPL
... .|. ....  .|  |    . .|. ..  .. | ...      || |.|. |||. |||.|||. ....|  .||    ||   |         |.
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

CVHCSAGCGRTGVLCTVDYvrqLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 |||||| |||||| ..|    |. |     .  .  |. ..|.||   |||  ||.|.|... ...
lvhCsaGvGrtGvlilsdl...liatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 55-293 1.2e-55 183.4 In-house 37-278 (287) alignment
Range on Protein: 55-293
Range on HMM: 37-278/287.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGhSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
 .|.|||| ||||.|.|||.||   | | ||||| |.. .     |.||.|||.. |. ||||.|.|  . ....  ||.|..|..| .|| . . |.. 
aavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GLFCITLIKEKWLNEDIMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSS----PDHMLAM---VEEARrlQGSGPEPLCVHCSAGCGRTGVLCTVDYV
| . ..|.. . .. .   |.|..     .|.| | ||...||||.... .       .| .   .| ||  ..|.  || ||...| ||.|.| ..  .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar..dasevGPlvvhddvGiGrsGillatlvl

RQLLLtQMIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 . |. ..         ||...|..| | ||.  |.|.|| ...  . 
vsrle.dlG..rvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 47-291 3.8e-55 181.8 In-house 37-282 (290) alignment
Range on Protein: 47-291
Range on HMM: 37-282/290.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEG--HSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
..  |  ..| ..||......||. |..|  ....     .|||  .| |   . .|||||||...|| |||.|.|.  | .|.| . .||.|...|  |
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WAQEQEPLqTGLFCITLIKEKWLNeDIMLRTLKVTFQKE---SRSVYQLQYMSWPDRG-VPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLC
|....     | | |.|..|. || ... |.|.|. ...   ..|| |.|  .|.. | |.     .|.. |  .    .| ... ||||.. ||..|.|
Wpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

TVDY-VRQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
...  . .   .. |     .|.|. ..| |.|  |||..||..... | . 
aaattinkcktegvi....dvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_PTPRN_pd Subfamily PTPRN 41-291 5.7e-55 181.1 In-house 42-291 (297) alignment
Range on Protein: 41-291
Range on HMM: 42-291/297.0
KADGvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRK
.|.  ... ......||.|||.|.|||||..|| |.  ... .|||||  .|   |    |||||||||..|. |||..||| || ||.. .|  |.| |
eaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

RCERYWAQEQEPLQtGLFCITLIKEKWLNEDIMLRT--LKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTG
.|.||| .| . .  ... . |. |.   .| ..|.  ||   ..|.|.| |. ..|||..|||.|.  .| .     .       |. ||||.|.||||
qckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtG

VLCTVDYVRQLLLTQMIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
| . .| | . ||  .   .  .   . ..| |||  |.|..|..| . .||. 
vyilidlvlnrllkGvk..eidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_PTPN1_pd Subfamily PTPN1 48-290 9.2e-54 177.1 In-house 24-269 (290) alignment
Range on Protein: 48-290
Range on HMM: 24-269/290.0
TVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
| .  .|||  .|||.|| ||| .|..|    |... |||| ...   .    || ||||||.|   ||..|||   | ..|  . .|... .| .|| |
treaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

EQE--PL--QTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGRTGVL
..|   |  .   . ..||.|.  ..  ..|.|...    .|.|....  |..||| |||.||  .| .. . |.         |  .||||| ||.| .
geeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

CTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
| || .  |.  .       . .|.|..||.|   .|| .| || | .. .
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 54-292 1.5e-53 176.6 In-house 45-278 (287) alignment
Range on Protein: 54-292
Range on HMM: 45-278/287.0
PENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEpLQ
..|  |||....|..|. ||.|     . | ||||  || |   . |.|....|. .|. .||.|...  |..|.| |.| || .. | .||..|.  . 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

TGLFCITLIKEKwLNEDIMLRTLKVTFQK---ESRSVYQLQYMSWPDRG-VPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLL
 | . |.|..|.  |.. . |.|.|. ..   . ..| | |. .|...| |..    .| . |  .  . .|  .. ||||.. ||....| ..   .  
lGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

LTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 |. .     .|.|. ..| |.| .||| |||.|... | .. 
kteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-292 1.2e-51 170.9 In-house 59-293 (319) alignment
Range on Protein: 54-292
Range on HMM: 59-293/319.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengRKRCERYWAQEQEP-L
..|  |||. ..|..|...| |  |. |  |||||  |. |      |||.||||. || ||||..||. .  |..        ...| .|| .. .   
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

QTGLFCITLIKEKwlnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHCSAGCGRTGVLCTVDYVRQ
. .   .....|    .. ..| ....    .|. |.. |  .. ||| ||| .|  .. .|.  | |.    ..... ||||||.|||||  ..| . .
erfkvkvdsveet...aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

LLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ--MF
 .  .       ....|  .|.||.  ||   || |.| .. .  .|
rmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 54-292 2.4e-51 169.9 In-house 23-257 (284) alignment
Range on Protein: 54-292
Range on HMM: 23-257/284.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengRKRCERYWAQEQEP-L
..|  |||. ..|..|...| |  |. |  |||||  || |      ||||||||. || ||||..||. .  |..        ...| .|| .. .   
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

QTGLFCITLIKEKwlnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHCSAGCGRTGVLCTVDYVRQ
. .   .....|    |. ..| ....    .|. |.. |  .. ||| ||| .| .....|.  | |.    ..... ||||||.|||||  ..| . .
erfkvkvdsvees...eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

LLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ--MF
 .  .       ....| ..|.||.  ||   || |.| .. .  .|
rmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

0041856 (Phosphotyrosine protein) phosphatases II 56-292 7.3e-51 167.7 In-house 1-171 (182) alignment
Range on Protein: 56-292
Range on HMM: 1-171/182.0
NVRKNRYKDVLPYDQTRvilsllqeegHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengrkrCERYWAqeqeplqtg
|. ||||.|.||||..|          ..|||| |...|   .  .|||||||..|. ||.|...| |...|....         .|.||.         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lfcitlikekwlnedimlrtlkvtfQKESRSVYQLQYMSWPDRGVPSsPDHMLAMVEEARRlqgsGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmip
                         ... | ..|..|..||| |||. .|..|...||...     ..|  ||||||.||||.|.  .....|       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

pDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 ..||...|  .|..|| .|.|..||.||.  . ...
.gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 21-290 3.2e-48 159.1 In-house 17-234 (392) alignment
Range on Protein: 21-290
Range on HMM: 17-234/392.0
REGAVLAGEFSDIQACSaawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
|  |....|| |.           .  . .. .. |..|||||..||||..||.| ....  .|||.|  .|...|   ||||.||| . .| ||||.|.
rhsalffeefhdlpgpd.......iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

EFGVKVILMACReIENGRkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS
.. |  | |  . ...|                                            .. |.| | ..  |||..||     .| ...| .   |.
qenvttiamvtk.lkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

GPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
   || .||||| |||||. ..| |      |.|.     .|..| ..|..||  |||.||| |.| .| .
ythpliihcsagvgrtgvvisidsvvahakktrmv....dvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 56-288 7.2e-47 154.4 In-house 56-279 (290) alignment
Range on Protein: 56-288
Range on HMM: 56-279/290.0
NVRKNRYKDVLPYDQTRVILSllqEEGHSDYINGNFIRGVDGslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPLQT
...|||||||   |.|||||.   . .. ||.  |...|..    .| |||.|  | .|.||.| . .| .| | |  ||.|. .||.|. . | | |  
efkknrykdvvcndktrvilk...dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GLFCITLIKEKWLNEDIMLRTLKVTFQKESR--SVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsgpePLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
| . ..  .|.  ...|...|| |  ... .   .. |. .||||. |. |   .| ..   |.. |    |. |||||| |||| . ...   |.||  
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldG

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
    .. | |.|  .|. | ..|| . ||  | . .
k...eldlldlvralrnsrlnsvqvdiqylalveil

0051429 (Phosphotyrosine protein) phosphatases II 83-296 5e-46 152.8 In-house 3-229 (272) alignment
Range on Protein: 83-296
Range on HMM: 3-229/272.0
HSDYINGNFIRGVdgsL------AYIATQGPLPHTLLDFWRLvWEFGVKVILMACREIENGRKRCERYWA-----------QEQEPLQTGLFCITLIKEK
 |.||| ... |           ......||||.|  ||||| .| |.|.|.. ..| | ||  |.|||.            . ..   | ...||..|.
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

wLNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPdhMLAMVEEARRlqgsgPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFS---
 | .|..||.| .|     .|.| |..|.|..|||.|||...  .|...|. ..     ..|. ||||||..|||... .... . .  . |  |.    
.llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--LFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTL
  |...| ..|.|||.||||||||.|||. ......| |
lyleeaveelraqrpgavqteeqylflyeallellrsll

0049772 (Phosphotyrosine protein) phosphatases II 48-290 1.1e-45 152.1 In-house 38-278 (314) alignment
Range on Protein: 48-290
Range on HMM: 38-278/314.0
TVAGSRPENVRKNRYKDVLPYDqTRVILSLLQEEGhSDYINGNFIRGVdgsLAYIATQGPLPHTLLDF----------WRLV--WEFGVKVILM------
..... ..|  ||||.|.||.| .||||. |  .| ||||| ....|.   |..|||||||..|. ||          ||.|  ... | .| |      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------ACREIENGrkrcERYWAQEQEPLQtglfcitliKEKWLNEDImlrtlkvtfqkeSRSVYQLQYMSWPDRGVPsSPDHMLAMVEEA
                ..  .||      ..|...| |.         .| . .|.             .| .... .. .|| ..| .........|  
adelsrLdaAlgKtpllildgng....neptaadlellk.........eelydpelf............erlgikylripvpDgsap.lledfdeflefi

RRLqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLltqmippDFSLFDVVLKMRKQRP-----AAVQTEEQYRFLYHTVAQ
...  . ..|. |||.||.||||......|.  ||       ..|| ...  .|..||      .... ||| | .. . .
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealle

0043147 (Phosphotyrosine protein) phosphatases II 82-286 5.8e-45 148.4 In-house 3-155 (172) alignment
Range on Protein: 82-286
Range on HMM: 3-155/172.0
GHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlKVTFQ
..||||| ... ..     .|||||||..|| ||||...| |...|......                                            .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

KESRSVYQLQYMSWPDRGVPsSPDHMLAMVEEARR-LQGSGPEPLCVHCSAGCGRTGVLCTVDYVRqllltqmipPDFSLFDVVLKMRKQRPAAVQTEEQ
...|...|..|..||| ||| .....| ..|  .. |. |  .| .||||||.||||.|.  ....          ..||...|  .|..|| |||...|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YRFLYH
|||||.
yrflyy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 49-292 1.2e-44 147.2 In-house 33-293 (301) alignment
Range on Protein: 49-292
Range on HMM: 33-293/301.0
VAGSRPENVRKNRYKDVLPYDQTRVILSLLQE--EGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
. | . || . ||.|.. .||. |.||.  ..    . .||| ..| |.  . ..||.|||. .|| |||||.|.  .  |.| . . |. ...||.|| 
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywp

Q-EQEPLQTGLFCITLIKEK----------------WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEA-RRLQGSGPEPLCVH
. |.|  . | | .||..|.                  |.  . |..||. .|.|..| |||  .||. ||   |  .|  ...   | |  |  |. ||
nseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVH

CSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
||.. .|.|| |.|.        . .     .|.|.  .|...| ||.| ||| ..|  . ...
CSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 56-288 1.3e-44 147.2 In-house 7-236 (239) alignment
Range on Protein: 56-288
Range on HMM: 7-236/239.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplQT
|  |||| ... ||..||.|  | .. |||||| ...|  |||  ||||||| .  .  ||||..|.    ||.|    ||  .|.| .|| .     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

GLFCITLIKEKWLNeDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  . .|| | . .  | ..||. .    | | | ||| ..  |||.|||     .| .  .  .    |  |  .||||| |||| .  .| . .    |
cnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
       .|. |  .|..||  ||| ||| |.. .|
k...tvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 56-288 1.4e-44 147.1 In-house 8-237 (239) alignment
Range on Protein: 56-288
Range on HMM: 8-237/239.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplQT
|  |||| ... ||..||.|  | .. |||||| ...|  |||  ||||||| .  .  ||||..|.    ||.|    ||  .|.| .|| .     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

GLFCITLIKEKWLNeDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  . .|| | . .  | ..||. .    | | | ||| ..  |||.|||     .| .  .  .    |  |  .||||| |||| .  .| . .    |
cnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
       .|. |  .|..||  ||| ||| |.. .|
k...tvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 55-288 1.8e-44 146.8 In-house 2-235 (237) alignment
Range on Protein: 55-288
Range on HMM: 2-235/237.0
ENVRKNRYKDVLPYDQTRVILSllQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQ
||  |||| ..  ||..||.|      . ||||| ....|.||.   |||.||||  .  |||..||.    ||.|    ||. ...| .|| . ..|  
enkiknrygnivaydhsrvvlk..gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

TGLFCITLIKEKWLnEDIMLRTLKVTFQ---KESRSVYQLQYMSWPDRGVPSSPDHMLA----MVEEARRLQGSGpePLCVHCSAGCGRTGVLCTVDYV-
 | . ..| |.. .  |  .|.| .. .   || | ..| |. ||||||||     .|     ...... .. ||  |  .||||| ||||..  .| . 
ygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg..pwiihcsagvgrtgiflvidaml

RQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
||    ...     ... |  . ..||  .||..|| |...|.
rqakekkvv....diynyvysieedrpyiiqtkdqyvfihqti

0046846 (Phosphotyrosine protein) phosphatases II 78-291 8.5e-44 144.7 In-house 6-172 (176) alignment
Range on Protein: 78-291
Range on HMM: 6-172/176.0
LQEEGHSDYINGNFIRGVdgslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQtglfcitlikekwlnedimlrtlk
| .....||||.|.| |     ..||||||||.|| ||.....| |...... . |.| || .| .|| .....                          
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

vtfqkesrsvyQLQYMSWPDRGVPSSpDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQllltqmiPPDFSLFDVVLKMRKQRP-AAVQ
           | ... ||| |||.. ...| ..|. |. . .| .|  ||||||.||||.|.  . ..          ..|..... ..|.|||  |||
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavq

TEEQYRFLYHTVAQM
|.|||||||. . ..
tpeQyrflyefelll

subfamily_CG7180_pd Subfamily CG7180 50-293 3.4e-43 142.4 In-house 36-291 (296) alignment
Range on Protein: 50-293
Range on HMM: 36-291/296.0
AGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRkRCERYWAQEQ
.| | ||  |||. .|.|||..||.|. |. | .|||||  .. .     .|| |..|  .|. .|||||.. ... . . ... .  .  .  || ...
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

ePLQTGLFCITLIKEKWLNeDIMLRTLKVTFQ------------KESRSVYQLQYMSWPD-RGVPSSPDHMLAMVEEARRLQGSG-----PEPLCVHCSA
   | | . . ...|| .  ..  ||.|.| .             | | | ..|.  |.    ||.|   .. ... .| ...        .|..|..| 
.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssd

GCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
| .|.|| ...|   .|.  .     . .|. | ..|..||  |.. |.|...| .. ... 
GasRsGvylaidanlelveke...eevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

0036282 (Phosphotyrosine protein) phosphatases II 84-285 4.9e-43 142.1 In-house 2-163 (174) alignment
Range on Protein: 84-285
Range on HMM: 2-163/174.0
SDYINGNFIRGVDGSLAYIATQGPLPhtlldFWRLVWEFGVKVILMACREIENGRKRCERYWAQeqeplqtglfcitlikekwlnedimlrtlkvTFQKE
||||| ... ..  .  .||.||||.     ||....|.|.....| ..|.|.|. .| .||                                 . . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRSVYQLQYMSWPDRGVPSSPDhMLAMVEEARRLQGS-GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLtqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYR
.|...|..|. |||.|||...  .| .|..... . . .  |. ||||||.||||.|.  ... ..||    ..    .|.| ..|.||| .|||..|||
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyr

FLY
|||
fly

0049260 (Phosphotyrosine protein) phosphatases II 91-285 1.2e-41 137.2 In-house 1-143 (152) alignment
Range on Protein: 91-285
Range on HMM: 1-143/152.0
FIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyQL
|| |.  . ..||||||.|.|| ||||...| |...|.| ... |.|.  ||.|.                                           | 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRqllltqmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLY
... ||| |||......| ...  ..|. .  .|  ||||||.||||.|.  ....          ..||...|  .|..|| ||....|.||||
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 37-295 3.5e-41 136.2 In-house 25-280 (307) alignment
Range on Protein: 37-295
Range on HMM: 25-280/307.0
SAAWKADGVCSTVAGSrpeNVRKNRYKDVLPYDQTRVILSLlqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIEN
 | .. .||      .   |  ||||.||   |..|... .  .   ||||  |..        .|..||||  |  .|| .. .  |. ..| |. || 
lakktpegvtveafsa...ntdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

GRKRCERYWAQEQEPLQT-----GLFCITLIKEKWLNED---IMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVH
.. .||.||  |.   ..        ... .  | |  |   | . |||| . ..||.. .||.  |||||||      . ..|  |  .    .|. ||
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....npvvvh

CSAGCGRTGVLCTVDYVRQLLLTQMIPPDfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
|||| ||.| . .. .|.. ... .   |  . ..| ..|.||. |.||| || .|.  . . |   
csaGvGrsGtivaislvqdkmiaGinckd..mkklveelrsqrhyaiqteaqylylhrvlleyflel

subfamily_ptpA1_pd Subfamily ptpA1 44-242 1.3e-40 134.4 In-house 35-249 (418) alignment
Range on Protein: 44-242
Range on HMM: 35-249/418.0
GVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGsLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCER
|   |  | .  |  |||| ..|| ..||| |  .|..  ||||| |.| |      .|.|||||| |. ||||.|||  ...|.|  || || | .|.|
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWAQEQEPLQ----------TGLFCITLIKEK-WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE--AR--RLQGS--GPEPLC
|| ..    |           | . . |..     . .|. | ...||. |.| . | ||  |||. .|   . .  ..     |  ..  |     |. 
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGCGRTGVLCTV
|||||| |||| .|| 
vhcsagvgrtgtfcta

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 48-302 5.9e-40 131.9 In-house 25-277 (283) alignment
Range on Protein: 48-302
Range on HMM: 25-277/283.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEeghsDYINGNFIR---GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
..  |  || ||||.....|.|| || |  . .    ||||  ||      . .  ||..|.|| .|  |||..|..  .  |.|  .  |. |..| .|
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WAQEQePLQTGLFCITLIKEkWLNEDIMLRTLKVTFQ---KESRSVYQLQYMSWPDRGvPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLC
| ..    . | | .|| || . ..  . . | .  .   |..  .   |.  | . | . ..   |  ..  . ||   .  |. ||||.| |||.|..
WPkrG.sedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

TVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV-AQMFCSTLQNASPH
..    . .||. .     .| ||  ||.||. |||| .||..... |  | .|   | |   
aasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 55-293 1.2e-37 124.2 In-house 54-290 (305) alignment
Range on Protein: 55-293
Range on HMM: 54-290/305.0
ENVRKNRYKDVLPYDQTRVILsllQEEGHSDYINGNFIRG-VDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ---EQE
 .. ||||.||   ||. | |   ..   ||||  |..   .     .|..|||| .|. .|| .| .  |. |.| |. .| |. .| .||     |. 
iaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

PLQTGLFCITLIKEKWLNED--IMLRTLKVTF-QKESRSVYQLQYMSWPDRGVPSSpdhMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQ
 |..|.    .   | .. |  | . .|..|.  ... || .||.  |||||||      |. .|    ..||   |. |||||| |||| . ...|. .
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc...kltslellsairgsk.vpivvhcsagigrtgtivaieyile

LLLTQ-MIPPdfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 .  .   ||   . ..|  .| ||  ..|.. || |..  . . | 
kiaenkpcpp...mpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 13-289 1e-35 118.1 In-house 9-276 (439) alignment
Range on Protein: 13-289
Range on HMM: 9-276/439.0
ERLEARGGREGAVLAGEFSDIQACSAAWKADgvcsTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTL
| .|     .  ..  .|  |.. |  ....    .   ..  .  ||||||| ..| |||.|  .    || ||| |.|.|      |||||||  .| 
ehvekldknkqeifkeifekinstspdyaci....aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

LDFWRLVWEFGVKVILMACREIENGRkrcerYWAQEQEPLQtGLFCITLIKEKWLNeDIMLRTLKVTFQ----KESRSVYQLQYMSWPDRGVPSSPDHML
 ||||||.|  .  |.| .  .|  .     ||  ..|    |  ..   ..  |  . ..| .||  .    .  |.| |..|..|||. ||.   |.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy.gdiavrvdrnielp.nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

AM---VEEARRLQGSGpePLCVHCSAGCGRTGVLCTVDYVR-QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 .   .. |   .  |  |. |||||| |||| . ..|    || | . .     .  .|  .||||   ||.  || |.| .| 
dflrainsandkeeyg..pvvvhcsagvGrtGtiialdialeqlklenkv....dikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 50-288 1.1e-35 117.7 In-house 31-265 (281) alignment
Range on Protein: 50-288
Range on HMM: 31-265/281.0
AGSRPENVRKNRYKDVLPYDQTRVILSL-LQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE
.  .| | .|||| ..   | .|| | . . ..  .|||  |.||       || ||||   |  ||||..|.     |.| |. .|  |..|  |. ..
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

QE-PLQTGLFCITLiKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLqgSgpEPLCVHCSAGCGRTGVLCTVDYVRQ
    ||   . ..  ..  .|. ..   |..... |.| . .  .  |||  || | . || .. . |    |   |  .||||| ||.| | .|.   |
ahcclqfdklsvsy.edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar..s..tppvihcsagvgrsgtlmaveialq

LLLTQMIPPDFSLFDVVLKMrKQRPAAVQTEEQYRFLYHTV
 . ...  ||       |..   | |.||| .|| .... .
sihshftlpdikqivshlrv.tgraasvqtlqqymliwkvl

0044763 (Phosphotyrosine protein) phosphatases II 67-286 1.1e-35 118.3 In-house 1-165 (178) alignment
Range on Protein: 67-286
Range on HMM: 1-165/178.0
PYDQTRVILSLLQEEGHSDYINGNFIRGVdgslAYIATQGPlphtlLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplqtglfcitlikekw
|.| |||.|| |. .  ||||| ..| .      |.....|      |...|..| |...|.. . |.|.|.  | .|| .| .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

lnedimlrtlkvtfqkesrsvYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippDFSLFDVVLK
                     .| ... .|| |||....|.|..||  .... . ..|  |||||| ||.|.|.  .....|        ..||....  
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRKQRPaAVQTEEQYRFLYH
.|..|| .|....|.|.|| 
vrerRp.ivpnpgqlrqLye

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 51-204 1.3e-35 117.7 In-house 28-183 (297) alignment
Range on Protein: 51-204
Range on HMM: 28-183/297.0
GSRPENVRKNRYKDVLPYDQTRVilSLLQEEGHSDYINGNFIRGVD--GSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-
  |.  .|||||.|.| .|.|||   ||.    .|||| ...   |    | || .||||  |. |||.||.| .|.|| | ..  |.||..|  || . 
akrnsslrknryrdilatddtrv..kllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EQEPLQTGLFCITLIKEKWLN-EDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSP
.|| |..| . .  . .   . . ..|  |.. ...||| |   |..|||| ||||  
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 56-292 4.4e-34 112.8 In-house 35-270 (285) alignment
Range on Protein: 56-292
Range on HMM: 35-270/285.0
NVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIR--GVDGSlAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPL
|   ||| ||   ..|||.|     .   |||  ...|  | | | .||.|||||| || |||.....  .  .|| |  .| | ..|  |. ..  | .
npdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

QTGLFCITLI--KEKWLNEDImLRTLKVTFQKE--SRSVY--QLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSgPEPLCVHCSAGCGRTGVLCTVDYVR
. | . |||   ||. .   | | .| |.  ..  |  .|  ..|   |||.  |     |. . .  ....    .|.||||||| |||  .  .||  
kfgkyeitlteckeeaiagti.lnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyat

qllLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
   .  |  |.  ..|.| .||  |  |||.  |. |||  . . |
...irimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 59-284 7.9e-33 108.5 In-house 53-273 (301) alignment
Range on Protein: 59-284
Range on HMM: 53-273/301.0
KNRYKDVlPYDQTRVIlSLLqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPLQTGLF
|.||. | | . .  .  .. ..|.   |  |.|     .  .|||||||. |  ||| ..  . |. | | ....|.  ..|| | ... .| |. | |
khryptv.PckPstav.evi.vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

CITLIKE-KWLNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRlqgsGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQm
 |.. .. . ||..|. |||.|.    . ..|.|   ||..|.||||| |  ..  ..| ...      .|. |||||| ||.  . . .|. . .... 
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylarevead.

ipPDFSLFDVVLKMRKQRPAAVQTEEQYRFL
  |   | . . ..|..|  .|||..|  ..
..ptieltealkhlrehrwngvqtnsqlywm

0051082 (Phosphotyrosine protein) phosphatases II 84-287 4e-32 106.2 In-house 3-148 (151) alignment
Range on Protein: 84-287
Range on HMM: 3-148/151.0
SDYINGNFIRGVdgslaYIATQGPLPhtllDFWRLVWEFGVKVILMACREIENGrkRCERYWAQEQeplqtglfcitlikekwlnedimlrtlkvtfqke
||||| ... |      .....|||.    ||..|..| |.|.|.. . | |.|   | .|. ...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRlqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippdFSLFDVVLKMRKQRPAAVQTEEQYRF
 . |.......||| |.| |.| .|...|....    .. |. ||||||.||||.|. .. . .          .||....  .|..|| .||...|..|
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqflf

LYHT
... 
qlfa

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 55-298 4.3e-32 105.9 In-house 51-295 (310) alignment
Range on Protein: 55-298
Range on HMM: 51-295/310.0
ENVRKNRYKDVLPYDQTRVILSLlQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
... |||| ||.  |..|| | . .   . |||  |...      ..| .|||| ||..||||....   . ||. |.  |.|| .|  ||         
kymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GLFCITLIKEKwlNEDIMLRTLKVTFQKESR------------SVYQLQYMSWPDRGVPSSPDHMLAmveeARRLQGSGPEPLCVHCSAGCGRTGVLCTV
|   .| . |    |.. .  | |||  .               |  ...  |||||||    | .      | |      |  |||||| .|..|....
gcirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvval

DYVRQLLLTQmIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLyHTVAQMFCSTLQN
..  . |          . .|. ...|.|   .||| || .. . |  .|. . ..
klkidkldrg.l..kvdaeevktellksraiciqtelqylii.drvriifargete

PTPc_DSPc_SM00012 187-289 6.9e-31 101.9 In-house 2-104 (105) alignment
Range on Protein: 187-289
Range on HMM: 2-104/105.0
VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP--EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFL
|....|..||| |||...|..| .... .. .      .|..||||||.||||.....|.. | | ..     ...|..| ..||||| .||||||| ||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YHTVA
|. ..
yrall

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 47-291 1.6e-29 97.7 In-house 23-258 (267) alignment
Range on Protein: 47-291
Range on HMM: 23-258/267.0
STVAGSRPEN-VRKNRYKDVLPYDQTRVILSLLQEEghsdYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENgrkRCERYW
||.. | .|.   .||. |.||||.|||||.  .||    |||  .. |     |.|.||.||  |  ||. .. . .| || .  .  ..      ..|
stisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfw

AQE---QEPLQTGLFCITLIKEkwlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
  .    .  |      .| ||   ..|  . ||.. |..||     | |    .  .   |     .   |.     |  || |.||.| ||.| . ..
PPkmgqakkyqdltvehsleke...endyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvi

DYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
|   . . |. .     .|| ..|.|.||.. |.| |.| ......|. 
dsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-291 2.6e-28 93.9 In-house 42-270 (288) alignment
Range on Protein: 55-291
Range on HMM: 42-270/288.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQ
.|  ..||...   | ||| ||    .    ||. | .         | .| ||  |.  .|... | .|. |.| |. .| |... . |.  .  |  .
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

TGLFCiTLIKEKWL--NEDIMLRTLKVTFQKESRS-VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQlll
 | .| | .|.|    .  . . .|... . | .  | .| .  |.| ||| .    | ..|  . ||    .|. ||.||| |||| |  .  . .   
igrlc.tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililiale...

TQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.  .. . ..  .. |.|..|  |.||| || ...  | . 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_CG42327_pd Subfamily CG42327 56-216 2.6e-28 93.6 In-house 28-192 (319) alignment
Range on Protein: 56-216
Range on HMM: 28-192/319.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
   |.|. .|.|  .|||.|    .. .. |.. ...|| | .   |||.| .|  .  ||||.|||   .||. ..   |.| |.| .|.  ..   .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

GL---FCITLiKEKWLNEDIMLRTLKV--TFQKESRSVYQLQYmSWPDRGVPSSPDHMLAMVEEARR
 |   . .|| |..  ..  .. || .    ..||| .    |  |.. .||...  ..||. |.| 
slyGdilvtl.kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

0048076 (Phosphotyrosine protein) phosphatases II 174-290 8.8e-27 88.9 In-house 34-141 (145) alignment
Range on Protein: 174-290
Range on HMM: 34-141/145.0
RTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQllltqmipPDFSLFDVVLKMRKQRPA
 .|  ... ..| ..|..|..|||.|||......|...|  .... .| .|  ||||||.||||.|.  . ...         ..||.... ..|.||| 
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqrpg

AVQTEEQYRFLYHTVAQ
||....|.||||  . .
avpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 169-286 6.8e-25 82.9 In-house 48-139 (144) alignment
Range on Protein: 169-286
Range on HMM: 48-139/144.0
EdimlrtlkvtfqkesrsVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRqllltqmiPPDFSLFDVVLKMR
|                 ..|.....|||.|||......|...|  .... .| .|  ||||||.||||.|.. . ..          ..||....  .|
e.................giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

KQRPAAVQTEEQYRFLYH
..|| ||....|.|||. 
srrpgavpnpgqlrfLle

subfamily_egg_pd Subfamily egg 55-299 1.6e-23 77.9 In-house 39-277 (307) alignment
Range on Protein: 55-299
Range on HMM: 39-277/307.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENgrKRCERYWAQ-EQEPLQ
.|  | | | |   | .|| | | .     |.|  | ..|      .| .| ||  |  ||||.|..  |. |.|     |.  .||| || . |...|.
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

T--GLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWpDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLLLT
|  | . |. .| .    | ..|  |.      .    |..  . |    |     | ..  .|.|     .|  |..  |. ....| ...     || 
tvpGslrienlkvdsk.adplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnls....kpvvvqdilGvskaatlvaieiallsllr

QMIpPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
  |   . .   |  .|..|. .|..  .| |.|  |. .|   . .|
Gpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 60-295 3.9e-23 76.6 In-house 47-279 (312) alignment
Range on Protein: 60-295
Range on HMM: 47-279/312.0
NRYKDVLPYDQTRVILSllQEEghSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-------EQEPL
||| ..  .|. |  |.   .|    ||  ||.. .     ...|||||  |   ||.|.  .|   |.. |  .|.| ..| .| ..       |.  .
nrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

QTGlFCITLIKEKWLNEDIMLRTLKVTFQK---ESRsVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDyvrQLL
 |  .|  .      .. |  | |||  .    ||. . . |. |||| |.| | |  | ..   .. .     |.  ||||| |||| |. ..    ..
yte.ycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlalie...smi

LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
 .   |    . |. . .||.|  .|..  || .  ..| ... | 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 56-147 7.2e-23 75.9 In-house 47-152 (350) alignment
Range on Protein: 56-147
Range on HMM: 47-152/350.0
NVRKNRYKDVLPYDQTRVILS--LL------QEEGHSDYINGNFIRGV------DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRC
   |||||..|||...||.|   |            .|||| |...        . .  |||||.||| |. ||.... . .|||||.   ..|.....|
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ERYWAQ
.||| .
yrYWqe

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 183-292 2.5e-20 67.5 In-house 184-287 (305) alignment
Range on Protein: 183-292
Range on HMM: 184-287/305.0
ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsgpePLCVHCSAGCGRTGVLCTVDYVRQLLL-TQMIpPDFSlfDVVLKMRKQRPAAVQTEEQY
..| | .  .. |||||||..   .| ..|.|| ..|    |. |||||| |||| .  ..|. . ||  |.|  |     .. |.|.||  ..||..||
karkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmleyildqllagqii.edtd..kilqkireqrnnsiqtdaqy

RFLYHTVAQMF
 |..  . ..|
lfvhqvilnyf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 69-299 3.5e-20 67.3 In-house 31-266 (290) alignment
Range on Protein: 69-299
Range on HMM: 31-266/290.0
DQTRVILSLLQEEGHSDYINGNFIRGVDGsLAYIATQGPLPHT-------LLDFWRLVWEFGVKVILMACREIENGRK----RCERYWAQEQE-PLQTGL
 .|||.|    .   .|||  |..   .| |. |.|| |. ..       . .|| .. .  || . | |   |. ..     |..|  .. .  |. . 
eatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

FCITLiKEKWLNEDIMLRTLKVTFQKES-RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARrlqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMip
. .   |.|  ..|.  |.| |.|..|    |   .. .| .. |. ..  .|....  .        |  |||  |  |  .| ...   |..  .   
ltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaets..

PDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
 ...| ||. ..||||  |....... |    .  ..  .|.. 
gsvkledvlkalrkqralaitsalelafvdagivllaievldqf

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 107-289 4.5e-19 63.0 In-house 99-285 (302) alignment
Range on Protein: 107-289
Range on HMM: 99-285/302.0
PLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPLQTGLFCITLIK-EKWL-----NEDIMLRTLKVTFQK----ESRSVYQLQYMSW
|   ||  .| |. .. | ..   |  .|.. |.|  |.... .. |. | .... .. .. |      ....| |.... .|      ..|  |.. .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPpdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
|| | |  ... | ..      .    . . |||||| |||| | .. |  || ... .     | ..|| .|. |  |||.|.|  .|   |.
pdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliylllcvt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 183-290 1.1e-18 61.9 In-house 87-192 (440) alignment
Range on Protein: 183-290
Range on HMM: 87-192/440.0
ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ-GSGPEPLCVHCSAGCGRTGVLCTVDYVrqlLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQY
|||.. | .| .|||.|||     .| |...    |  .|  || ||||||.|||||. .|| .   |       .  .| ..  ||..||  ||| |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsi...lreakrsdqidifsfinsmrnnrpqmvqtpeqy

RFLYHTVAQ
 |....| .
afvheavle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 185-293 2.8e-18 60.8 In-house 215-345 (350) alignment
Range on Protein: 185-293
Range on HMM: 215-345/350.0
RSVYQLQYMSWPDRGVPSSPDHMLAMVE----------EARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIPPDFS-----------LFD
  |||||.  |.| ..   |  .| ..|              |. .  .|. ||||||.||||.|.|.|.. . ..  ...  ..            .. 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

VVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
.|...||||   ||. .|. |.|...  .| 
ivnelrkqrismvqnldqfifiYeallfyfa

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 111-307 7.2e-18 59.6 In-house 40-235 (255) alignment
Range on Protein: 111-307
Range on HMM: 40-235/255.0
TLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTgLFCITLIKEKwLNEDIMLRTLKVT--FQ--KESRSVYQLQYMSWPDRGVPSSPDH
|.  |.. .   . .|. | |   |.|...|..|.  |..  .  |  ....  |    |..||||..|  .   |. . |   .|  |...  |  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

MLAMVEEARRlqgSgpEPLCVHCSAGCGRTGVLCTVDYVRQLL---LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFcSTLQNASPHY
.| ..  .|    |   .. ||||.| ||.  .  ...| | .   | .    ..    .. ..|..|..|..|  |  |   .| ...    ..   .|
ilnilkvvrd...s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgeleaky

QNIK
|.|.
qeir

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 55-291 9e-17 55.6 In-house 46-278 (303) alignment
Range on Protein: 55-291
Range on HMM: 46-278/303.0
ENVRKNRYKDVLPYDQTRVILSllqeegHSDYINGNFIRgVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
.|. |||. ||.  |...| ||       | ||  ...  .| |   | || ||.||  |||... |  ||..|.   . |  .   .  . ..|. |. 
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GLFC--ITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSS--PDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDYVRQLL
      .  .|.  | .   |. | |.  .    ..  .| .||   .||   |  .  . .    |.   . .|      .||||.| ..  .     |
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

LTQmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
 ..   . . |  .. ..|. |  |||   |. ..|  .|. 
hse..qasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_hpo-7_pd Subfamily hpo-7 110-308 3.4e-16 53.9 In-house 45-245 (263) alignment
Range on Protein: 110-308
Range on HMM: 45-245/263.0
HTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTgLFCITLIKEKWLNeDIMLRTLKVTF----QKESRSVYQLQYMSWPDRGVPSSPD
 |.  |.. .   . .|. | |   |.|...|..|.  |..  |  |  ...   |  . |..|.||...     .|. . | . .|  |...  |  . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.lanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

HMLAMVEEARRLqgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLL---LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST--LQNAS
 .| ... || .      .| ||||.| ||.     .. | | .   | .    ..    .. ..|..|..|..|  |  |   .| ...      ....
eilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgele

PHYQNIKE
 .||.|..
akyqeirk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-286 3.9e-16 53.8 In-house 3-198 (199) alignment
Range on Protein: 97-286
Range on HMM: 3-198/199.0
GSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQE-PLQTGLFCITL---IKEKWLNEDIMLRTLKVTFQKESRSVYQLQY
|   ||||| || .|. |||..||| |   |.|   .  |       ||.  .    . | ...|      .       .. | ..|    .| . . |.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MSWPDRGVPSSP---DHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
 || ..  |        ..|  | ... .     |. |||| | | |||. ..|  ||    ..       ||.|  ..|. |   . . ..| |.| 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 98-286 4.6e-16 53.6 In-house 3-197 (198) alignment
Range on Protein: 98-286
Range on HMM: 3-197/198.0
SLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQE-PLQTGLFCITL---IKEKWLNEDIMLRTLKVTFQKESRSVYQLQYM
   ||||| || .|| |||..||| |   |.|   .  |       ||.  .    . | ...|      .       .. | ..|    .| . . |. 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDRGVPSSP---DHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
|| ..  |        ..|  | ... .     |. |||| | | |||. ..|  ||    ..       ||.|  ..|. |   . . ..| |.| 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 56-151 4.7e-16 53.4 In-house 48-140 (305) alignment
Range on Protein: 56-151
Range on HMM: 48-140/305.0
NVRKNRYKDVLPYDQTRVILsllQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP
.  |||||||   |. || |   .     .||  |..     .  .| || || .|  ||| . ..  |. |.| |  .| | |.|  |.| ....
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 56-147 3.5e-15 50.2 In-house 48-155 (349) alignment
Range on Protein: 56-147
Range on HMM: 48-155/349.0
NVRKNRYKDVLPYDQTRVILSLL------QEEGH--------SDYINGNFIR--GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRK
   ||||||.|||. .||.|          .. .         |||| |...   ..    ||||| ||| |. ||....   |||..|    . |.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

RCERYWAQ
.|..|| .
kcdiywqe

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 55-295 3e-14 47.1 In-house 50-288 (302) alignment
Range on Protein: 55-295
Range on HMM: 50-288/302.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTL---LDFWRLVWEFGVKVILMACREIENGRkRCERYWAQEQEP
.|..||. .||  .|...|.|.    .   .|.|.  .   . .   | .| |   .     .|||.|..  .. . .. .| |  .   . .. .... 
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-LQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYM--SWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQL
 .. | . .   | .  .|. .  .. |  .  | ||    |.   |..  || .  .. . ...   .. .. |.. .    |.|| |.. |.  . . 
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

LLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
| ..    .    ..| ..|.|||.||.. .|| .|| ...  .   
lqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 180-288 7e-14 45.9 In-house 212-340 (349) alignment
Range on Protein: 180-288
Range on HMM: 212-340/349.0
F-QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVE----------EARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQllLTQMIPPDFSL-------F
. ...   ..|||.  |.| ..   |  .|  .|              |. .   .| |||||||||||||.|.|.. .  . .. . ..         .
lavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls..ileplqnesnkiklqallk

DV----VLKMRKQRPAAVQTEEQYRFLYHTV
|.    | ..|||| . ||   |. ..|...
Dlisiivnelrkqrismvqnlaqfiaiyeal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 218-288 9.6e-13 42.6 In-house 224-291 (297) alignment
Range on Protein: 218-288
Range on HMM: 224-291/297.0
QGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSlfdVVLKMRKQRPAAVQTEEQYRFLYHTV
.   . .| |||||| ||.||.   | . . |  . ||   .   .. ..|.||.  ||| ||. .||. |
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaa...ilsilreqrarlvqtleqfellydav

subfamily_CG42327_pd Subfamily CG42327 223-294 1.6e-12 41.8 In-house 248-316 (319) alignment
Range on Protein: 223-294
Range on HMM: 248-316/319.0
EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTvAQMFCS
 || |||| | ||||.. . |   . | .     |  . ..|  .|..|  ||.| ||| |.|.. ..... 
GPlvvhcsdGvGrtGlviasdiairsleeskrsvd..iPqlvssvrrdrasavltkeqyefiykv.lseyak

subfamily_eak_pd Subfamily eak 47-207 2.6e-12 40.8 In-house 43-201 (332) alignment
Range on Protein: 47-207
Range on HMM: 43-201/332.0
STVAGSRPENVRKNRYKdVLPYDQTRVILSLLQEEgHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
|   ..| |.|..| .| ..|||.  | |.  | . .  |||   .   .    || |  .    .  ||..| |     |..   ..|.. .. ..|. 
sisetarleavnrnvvk.ivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

QEQ-EPLQTGLFCITlIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHM
..  | |. | . ..  ||   .. .  | |...   |.  |.  ..  | .  .|   | .
dktreelkfGildve.rkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedfl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 55-127 3e-11 37.4 In-house 36-113 (347) alignment
Range on Protein: 55-127
Range on HMM: 36-113/347.0
ENVRKNRYKDVLPYDQTRVILSLLQE-EGH----SDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVI
 .. ||| |||   |.|||.||  .   ..      |||   |.  . |  || || |||.|. |||..|    |  .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqv

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 47-106 9.6e-11 35.7 In-house 39-95 (95) alignment
Range on Protein: 47-106
Range on HMM: 39-95/95.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLlqeEGHSDYINGNFIRGVDGSLAYIATQG
.  .||   |. |||. ...||| |||.|.       |||||  |. |     .|||.||
pytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 99-182 2.8e-09 30.8 In-house 236-315 (440) alignment
Range on Protein: 99-182
Range on HMM: 236-315/440.0
LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACReIenGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEdIMLRTLKVTFQK
 |.|||| ||  |.||||||| .. .  |.|  . .    | |  ||  .   .  | | .     . .|  . .|||.. ...
nafiatqmpldstvldfwrlvhdyristiimlnq.l..ndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkyke

subfamily_PTPDC1_pd Subfamily PTPDC1 191-285 2.8e-09 31.7 In-house 86-169 (182) alignment
Range on Protein: 191-285
Range on HMM: 86-169/182.0
QYMSWPDRGVPSsPDHMLAMVEEARRLQGSGpePLCVHCSAGCGRTGVLCTVdyvrQLLLTQMIPPDfslfDVVLKMRKQRPAAVQTEEQYRFLY
  ..|.| ||.|  ...| .|  .      |   . ||| || |||||| ..     |. .. . ..    . . ..|..|| ..|| || ... 
ynfgwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliac....ylvyakrltae....kaiklvrskrpksiqtreqvelvk

0038934 (Phosphotyrosine protein) phosphatases II 189-293 5.8e-09 31.4 In-house 81-178 (194) alignment
Range on Protein: 189-293
Range on HMM: 81-178/194.0
QLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHT
.   . .||.|.. | . .|  .. . .     | .   ||| || ||||.|.    .  |        ..|. . .  .|  || |... .... |.  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl........gmsaeeAialfrekRpgaipnqdyleallkr

VAQMFC
. ... 
ykelrk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 55-96 9.5e-09 29.2 In-house 38-78 (244) alignment
Range on Protein: 55-96
Range on HMM: 38-78/244.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGhSDYINGNFIRGVD
 |. |||| ..||.|.||||||  ..|| ||||| |.|.| .
anatknryinilpfdetrvilssskkeg.sdyinanyiqgsq

subfamily_ptpA1_pd Subfamily ptpA1 257-293 1.2e-07 25.8 In-house 363-399 (418) alignment
Range on Protein: 257-293
Range on HMM: 363-399/418.0
DFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
|| || .|||.|.|||  ||  ||| | |.|. .   
dfnlfsivlklreqrpgmvqqleqylfcyktildeiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-96 2.7e-07 24.3 In-house 42-87 (440) alignment
Range on Protein: 51-96
Range on HMM: 42-87/440.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVD
 | |.|  ||||...| ||..||.|  ..   .|||||  .| |..
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 66-153 1e-06 23.1 In-house 3-76 (130) alignment
Range on Protein: 66-153
Range on HMM: 3-76/130.0
LPYDQTRVIlsllqeegHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACrEIENGrkrcERYWAqEQEPLQ
|... .|.           .||| .|.  .. .  |. || ||  | .|||... |  | |...    .|.     . ||  . |||.
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywp.dsePle

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 56-144 1.4e-06 22.0 In-house 34-120 (332) alignment
Range on Protein: 56-144
Range on HMM: 34-120/332.0
NVRKNRYKDVLPYDQTRVILSllQEEGHSDYINGNFIRGVDGSLAYIATQGPL-PHTLLDFWRLVWEFGVKVILMAcREIENGRKRCERY
|.  ||   .  .|..|| |.   ..|. |. | ... |     ||| .| |.  ||   |||.| |    .||.   .|.. .||   |
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf.gdidekqkrkapy

subfamily_DSP23_pd Subfamily DSP23 206-286 2.3e-06 22.3 In-house 72-140 (148) alignment
Range on Protein: 206-286
Range on HMM: 72-140/148.0
HMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQllltQmippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
... .||||   .    | . |||  | |||| . .  .|..    .    ...  . . ..|..|| .|.| || . ...
efvrvveeaeekn....eavsvhcllgrgrtgtmlacylvke....r....klaaaeaiaevrrlrpgsvetveqeklvrd

PTEN_1 190-240 3.5e-06 21.9 In-house 97-148 (196) alignment
Range on Protein: 190-240
Range on HMM: 97-148/196.0
LQYMSWPDRGVPSsPDHMLAMVEEARRLQGSGPE--PLCVHCSAGCGRTGVLC
   ....| |.||  ..........     | |.     ||| || ||.|...
ylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 227-289 3.5e-06 21.2 In-house 2-61 (69) alignment
Range on Protein: 227-289
Range on HMM: 2-61/69.0
VHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
||||.| |||| . ..      . .. .     .|. |  ||| ||  |  |..| |.. ...
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalv

subfamily_eak_pd Subfamily eak 227-307 4e-06 20.5 In-house 241-316 (332) alignment
Range on Protein: 227-307
Range on HMM: 241-316/332.0
VHCSAGCGRTGVLCTVDYVRQLLlTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMfcstLQNASPHYQNIK
. .. |  |.||.  .| . .|.  . .   .|. |..||....|  .| .. |. |.|. | .     |..  ......|
iqsarGsaraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy....llrrnnrlrdlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 226-289 4.3e-06 21.0 In-house 2-62 (69) alignment
Range on Protein: 226-289
Range on HMM: 2-62/69.0
CVHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 ||||.| |||| . ..      . .. .     .|. |  ||| ||  |  | .| |.. ...
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalv