Gene PTPN18 in Homo sapiens

Synonym: BDP1, PTP-HSCF, PTPN18

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP073_AA protein Get Run
HsapP073_AA_8-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 24-299 1.2e-129 426.3 In-house 8-284 (290) alignment 
Range on Protein: 24-299
Range on HMM: 8-284/290.0
AVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFG
. .| ||......|...||. |.|| ||...|||.||||||.||||..|| ||  .|| .|||||.|||.||.|.|.|||.|||||.|| ||||..||. 
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

VKVILMACREIENGRKRCERYWAQE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP
|....|||||.|.|.|.|||||..| .|.|..| |..||..||....|...|||||..|||||.|||..|..|||.|||||....|...|..|.|| |  
veivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesed

EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
.||.||||||.||||.....||||.|| ...||.....||.||..||||.|.|||.|||...|..||......|.. 
aPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
0051299 (Phosphotyrosine protein) phosphatases II 9-290 1.3e-89 295.8 In-house 8-284 (288) alignment 
Range on Protein: 9-290
Range on HMM: 8-284/288.0
RSFLERLEARGGREGAVLAGEFSDIQACSAAwkadgvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPL
...|......  .  . |. || ..... .       ... |...|||. ||||.|.||||..||.|| |.....||||| ..|.| . . ..|||||||
eellklvlkllangltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPS
|.|. ||||.||| .|.|| | ....|.||. |..|| . ...|. | ...||..|.  ..|...|||.||      ...||| |....|..||| |||.
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
||...|......|. . ||. | .||||||.||||.....|.. ..|...     ......| ..|.||| .|||.|||||.|.... 
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0050432 (Phosphotyrosine protein) phosphatases II 27-293 3e-89 294.7 In-house 45-300 (308) alignment 
Range on Protein: 27-293
Range on HMM: 45-300/308.0
AGEFSDIQACSAawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqeEGHSDYINGNFIRGV--DGSLAYIATQGPLPHTLLDFWRLVWEFGV
  || .....        .... ....|||. ||||||.||||..||.|     ...||||| ....|   . . ..||||||||.|. ||||.||| .|
eeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

KVILMACREIENGRKRCERYWAQE--QEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgs
.|| | ....||||. |..||  |  ...|. | |..||..|.. ..|...|||..|.   .||| |....|..||| |||.||...|...|..|. .  
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
...| .||||||.||||.....|.. ..| ..     ...|..| |.|.||| .|||.|||.|||.... .. 
pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0046845 (Phosphotyrosine protein) phosphatases II 41-294 9e-89 292.9 In-house 13-276 (284) alignment 
Range on Protein: 41-294
Range on HMM: 13-276/284.0
KADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGV-----DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREI
. . ..|. .. .|||. ||||||.||||..||.|. |... ..||||| ....|      . . ..||||||||.|. ||||.||| .|.|| | ....
tvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelv

ENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHC
||||. |..|| .|.|.|. | |..||..|.. ..|...|||..|.    .||| |....|.||||.|||.||...|......|.|.   .|..| .|||
engrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

SAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
|||.||||.....|.. ..| .. ..  ......| ..|.||| .|||.|||||.|.... .. .
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 42-296 4.6e-87 287.4 In-house 25-281 (297) alignment 
Range on Protein: 42-296
Range on HMM: 25-281/297.0
ADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRC
    .|. ....|||. ||||||.||||.|||.|    ....|||||.... | | . ..||||||||.|. ||||.||| .|.||.| ....|.||. |
llllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

ERYWAQE-QEPLQTGLFCITLIKEKW-LNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGR
..||  | .|.|. | | .||....  |..|. ||||.||.   .||| |....|..||| |||.||...|...|..|. .    ...| .||||||.||
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTL
.|.....|.. |.| .... . ......|.|.|.||| ||||.|||||||..... . ..|
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 45-296 1.9e-86 285.5 In-house 32-282 (317) alignment 
Range on Protein: 45-296
Range on HMM: 32-282/317.0
VCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
....  ...|||  ||||.|.||||..||.|| |..  .||||| ... | . . ..||||||||.|. ||||.||| ||.||.| ... |.||. |..|
ldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqY

WAQeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
| . .|.|. | |..||..|.. ...| ||||.|.    .||| |....|..||| |||.|||..|...|..|. . ....|..||||||.||||.....
wpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaa

DYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC--STL
... ..| . .   .......| ..|.||| ||||.|||||||  .....    ||
ylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0045450 (Phosphotyrosine protein) phosphatases II 31-291 4.4e-85 281.4 In-house 34-303 (307) alignment 
Range on Protein: 31-291
Range on HMM: 34-303/307.0
SDIQACSAAWkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFI--------RGVDGSLAYIATQGPLPHTLLDFWRLVWE
 ... .   .    .... ....|||  ||||||.||||.|||.|| |... ..|||||....         | | ....||||||||.|. ||||..||
ekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

FGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
 ||.||.| ....|.||. | .|| .|.|.|. | |..||..|.   ... .|||.||   . .||| |....| .||| |||.|....|...||.|. .
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

GS--GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
..  ...| .||||||.||||.... ... ..| .. . .|..|...| ..|.||| |||..|||||||. ... 
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0047943 (Phosphotyrosine protein) phosphatases II 26-289 2.8e-84 278.1 In-house 14-269 (273) alignment 
Range on Protein: 26-289
Range on HMM: 14-269/273.0
LAGEFSDIQACSAawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVK
|. || ... .        .... ....|||  ||||||.||||..||.|    ..|.||||| ....| . . ..||||||||.|. ||||.||| .|.
lleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

VILMACREIENGRKRCERYWAQEQE--PLQTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS-
|| | ....|.||. |..|| .|..  .|. | |..||..|.. ..|...|||..|.   .||| |....|..||| |||.|....| ..|..|. . . 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 ...| .||||||.||||.....|.. ..| .      ......| ..|.||| .|||.|||||||....
psngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyeall
DSPc_SM00195 47-292 1.5e-83 275.5 In-house 17-262 (263) alignment 
Range on Protein: 47-292
Range on HMM: 17-262/263.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
.|  . ...|..|||||..||||.|||.|.  ... .||||| |.|.| . . .|||||||||.|. ||||.||| .||.|.| ..| |||...|.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

QE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVD
.| ... . | . ..|....  ...| ||||..|...  |.|.|.|.|| .|||.|||.|....|.......  . .  .|..||||||.||||...|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

YVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.. . | ..     ...|..| ..||||| .|||.|||.|.|.......
iilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 47-292 1.5e-83 275.5 In-house 17-262 (263) alignment 
Range on Protein: 47-292
Range on HMM: 17-262/263.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
.|  . ...|..|||||..||||.|||.|.  ... .||||| |.|.| . . .|||||||||.|. ||||.||| .||.|.| ..| |||...|.||| 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

QE-QEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVD
.| ... . | . ..|....  ...| ||||..|...  |.|.|.|.|| .|||.|||.|....|.......  . .  .|..||||||.||||...|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

YVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.. . | ..     ...|..| ..||||| .|||.|||.|.|.......
iilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 27-292 1.7e-82 272.6 In-house 35-289 (297) alignment 
Range on Protein: 27-292
Range on HMM: 35-289/297.0
AGEFSDIQACSAawkadgvcSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGVDG-SLAYIATQGPLPHTLLDFWRLVWEFGV
  || ... .          ... . .|||. ||||||.||||..||.|. . .   .||||| ... | |  . ..||||||||.|. ||||.||| ||
llefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

KVILMACREIENGRkRCERYWAQEQEplQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GP
.||.| ....|.||  |..|| .|..  . | |..||.|..  ......|||.||  .||| |...||..||| |||.|....| ..|..|. . .  ..
tvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.| .||||||.||||.... ... ..| .     .......| ..|.||| ||||..||||||. .....
gpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 10-289 7.6e-82 270.2 In-house 6-274 (278) alignment 
Range on Protein: 10-289
Range on HMM: 6-274/278.0
SFLERLEARGGREGAVLAGEFSDIQACSAawkadgvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLP
..|..|. ..  . ..|  || ... .         ...  . .|||. ||||||.||||..||.||||... .||||| ... | . . ..||||||||
dllkallelllnlktllllefeellsfkl.......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlp

HTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAqeQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHM
.|. ||||.||| ||..|.| ... |.||. | .||   ...|. | | .||.||.  ..|...|||.||    .||| |....|..||| |||.|....
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

LAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
| .....|. . . ..|..||||||.||||........ ..| .      ..|...| ..|.||| ||||..||||||. ..
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRD_pd Subfamily PTPRD 48-294 7.2e-81 267.5 In-house 40-283 (564) alignment 
Range on Protein: 48-294
Range on HMM: 40-283/564.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
. | . |.| .||||.....||..||.|| .. .  ||||| .|| | . . |||||||||..|. ||||.|||  ...| |  .  |.|...|..|| .
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

EQePLQTGLFCITLIKEKWLnEDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYV
.. . . | . .|| .|. | .|...||.|.  . ..||| | | ...||||.||| |. ..|..... |.|. .. .|. |||||| ||||. ...|..
kg.tetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividam

RQLLLTqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
 . . .     .  .. .| ..||||.| ||||||| |........  .
lerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0045098 (Phosphotyrosine protein) phosphatases II 50-292 3.2e-77 254.9 In-house 27-272 (278) alignment 
Range on Protein: 50-292
Range on HMM: 27-272/278.0
AGSRPENVRKNRYKDVLPYDQTRVIlsllqeeghsDYINGNFIRGVdgSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQ
 . ...|. ||||||.||||..||.          |||| ..|.|   . ..||||||||.|. ||||..|| |..||.|.....|.||. |..||   .
palylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.g

EPLQTGLFCITLIKEKWLnEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPSSP--DHMLAMVEEARRLQG-------------SGPEPLCVH
..|. | |..||..|..| .|. ||||.||         ||| |..|.|..||| ||||.|  ...| ..|. |. .              ....|  ||
gsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGCGRTGVLCTVDYVRQLLltqmiPPDFSLFDVVLKMRKQRPA-AVQTEEQYRFLYHTVAQMF
||||.||||.|. ......||     .. ..|...| ..|.|||  |||..|||||||. .....
CsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 48-291 5.6e-77 254.0 In-house 3-245 (249) alignment 
Range on Protein: 48-291
Range on HMM: 3-245/249.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
.  ...|||. ||||.|.||||..||.|| |..  .||||| ..| | . . ..||||||||.|. ||||..|| |..||.|.... |.||. |..|| .
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eQEPLQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGRTGVLCTVD
 ...|. | | .||..... ..|...|||..|    .||| |...|| .||| |||.|....|...|..|  . .   ..|..||||||.||||.... .
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

YVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.. ..| .     ...|...| ..|.||| |||..|||||||  ... 
lmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 56-289 3.8e-76 251.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 56-289
Range on HMM: 1-234/235.0
NVRKNRYKDVLPYDQTRVILslLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQT
| .||||||.||||.||| |   ..||.||||| |...| . . ..|||||||..|. ||||.||.  |||| | ... |.||. |..||  .|.|.|..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GLFCITLI-KEKWLNEDIMLRTLKVTFQKES---RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLL
| ....|  |||  .....||.|... .||.   |.|.||.| .|||.|||.||...| .... .. . .  .|..||||||.||||.....|.. . | 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
..     ......| ..||||| .||..||| |||....
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 56-289 3.8e-76 251.0 In-house 1-234 (235) alignment 
Range on Protein: 56-289
Range on HMM: 1-234/235.0
NVRKNRYKDVLPYDQTRVILslLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQT
| .||||||.||||.||| |   ..||.||||| |...| . . ..|||||||..|. ||||.||.  |||| | ... |.||. |..||  .|.|.|..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GLFCITLI-KEKWLNEDIMLRTLKVTFQKES---RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLL
| ....|  |||  .....||.|... .||.   |.|.||.| .|||.|||.||...| .... .. . .  .|..||||||.||||.....|.. . | 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

TQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
..     ......| ..||||| .||..||| |||....
aeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 52-290 1.5e-75 249.0 In-house 5-241 (245) alignment 
Range on Protein: 52-290
Range on HMM: 5-241/245.0
SRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQeQEP
..|||. ||||.|.||||.|||.||  ... .||||| ... | . .  .||||||||.|. ||||..|| |...|.| ..| |.||. |..|| . .|.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

LQTGLFCITLIKEKWlNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG-SGPEPLCVHCSAGCGRTGVLCTVDYVRQL
|..| |..||..|.. ..|...|||.||    .||| |....|..||| |||......| ..|..|. .  ....|..||||||.||||........ ..
ltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
| . .   ..||...| ..|.||| ||||..||||||. ...
lekel...gvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 45-308 4.2e-75 247.7 In-house 36-298 (318) alignment 
Range on Protein: 45-308
Range on HMM: 36-298/318.0
VCSTVAgSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
| |. .   | | .|||| ..|.||.||| |. |..|  ||||| |.| |   . ||||.|.|||.|. ||||.||| . .||.|  .| |.|.....||
vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WAQEQePLQTGLFCITLIKEKWLnEDIMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ-GSGPEPLCVHCSAGCGRTGVLCT
| ... . . |   ..| .|. | .| .||..||| .  .||| | | .| ||||.|||.|. ..|..| .... |  || .|. |||||| ||||| ..
WPskg.srsygklvvelkeevel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfia

VDYVRQLLL-TQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS--TLQNASPHYQNIKE
|| . . .   ...     .|..| ..|.||.. ||||.|| |.|... ..  |  |  .||   ..|.|
vdillerikaealv....Dvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire
0037934 (Phosphotyrosine protein) phosphatases II 51-291 2.1e-73 242.2 In-house 5-241 (243) alignment 
Range on Protein: 51-291
Range on HMM: 5-241/243.0
GSRPENVRKNRYKDVLPYDQTRVILsllqeEGhSDYINGNFIRGVDGslaYIATQGPLPHTLLD----FWRLVWEFGVKVILMACREIENGRKRCERYWA
...|||. ||||.|.||||..||.|     || |||||.|.|.....   .||||||||.|. |    |||..|| |..||.| ....|.||. |..|| 
allpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

qeQEPlQTGLFCITLIKEKWLnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRL--------QGSGPEPLCVHCSAGCGR
  .|  . | |..||..|..| .|...|||...    ....| |....|..||| |||.||...|....|.|          . .. .|..||||||.||
..gev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVLCTVDYVRQLLltqmippDFSLFDVVLKMRKQRPA-AVQTEEQYRFLYHTVAQM
||.|.. ... .||       ...|...| ..|.|||  ||||..||||||. ....
tGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 47-295 4.2e-73 240.9 In-house 42-288 (293) alignment 
Range on Protein: 47-295
Range on HMM: 42-288/293.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
...| ....|  ||||...||||..|| |. |..| .||||| |.|.|      .||||||||.|. ||||.|||  ...|.|  . .|.|...||.|| 
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

QEQEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ--GSGPEPLCVHCSAGCGRTGVLCTVDY
...|| . |   .||..|. | || ..|.||.. .||.|.| |....|||| |||.... .|..|.. |. .   .  .|. |||||| ||||.. ..| 
adeepvlyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

VRQLLLTqmipPD-FSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
. | . .     |   .| .| ..|..|   ||||.|| |....| ... ..
llqaiee....edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPN6_pd Subfamily PTPN6 27-291 2.5e-72 238.5 In-house 29-296 (306) alignment 
Range on Protein: 27-291
Range on HMM: 29-296/306.0
AGEFSDIQACSaawkADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSlLQEEGHSDYINGNFIRG--VDGSLAYIATQGPLPHTLLDFWRLVWEFGV
  || ..|       |  . |   |..||| .||||| .||.|.|||||.  ..   |||||.|.|..   . . .|||||| |..|. ||||.||.   
eeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

KVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWlNEDIMLRTLKV---TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSG
.||.|. .|.| |...| ||| .|.|  ..|   .| ..||  ..| .||.|.|   ...||.|.|.|... |||| |||..|...|...|. .| | . 
rvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks.ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

----PEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
    . |..|||||| |||| .  .| . .|. .. .  |. . ..| ..|.||   ||||.||.|.|..... 
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 47-292 2.4e-70 231.8 In-house 32-276 (281) alignment 
Range on Protein: 47-292
Range on HMM: 32-276/281.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
...|  ..||| ||||...  ||.||| ..  .|. ..|||| ||. |..|  .|||||||.|..| .||..|||  |..| |  ||||.|. .| ||| 
tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP

QEQEPLQTGLFCITLIKEKWlNEDIMLRTLKV-TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDY
.... |. | . .. ..|.  ..  . |..|. . . |.|.| ||.|..||| |||... ..|   .| ..|. .    ||..||||| ||||.  ..| 
ddnselkygdvtvkstaeee.katyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr

VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
. . . ...  .. .. .|| ..||.|   |||  ||.|.|..| ...
lvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN3_pd Subfamily PTPN3 49-292 7.5e-70 230.0 In-house 34-275 (280) alignment 
Range on Protein: 49-292
Range on HMM: 34-275/280.0
VAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIR----GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
 |  .|||. ||||.|.||||.|||.|    .|...|||| |..     . . .  ||||||||..|  |||..|||  ...|.|    .|.||..| .|
saarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WAQEQEPLQTGLFCITLIKEkWLNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
| .... |. | | ... ||   .. ..|| | .. ..  |.|.. ||||..||| |||......| .||. |.|. .  ||. |||||| |||||| ..
WPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DYVRQllLTQMIpPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
.   .  |...   ..   |.| .|| || . |||..||.|. ... ...
etala..lieaa.epvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 47-292 4.4e-67 221.1 In-house 38-279 (288) alignment 
Range on Protein: 47-292
Range on HMM: 38-279/288.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
|. ||....| .||||...||||..|| |  |.||  .|||| ..| | ... .||||||||..|. |||.||.|  .. |.|    .|.|...||.|| 
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP

QEQEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVR
....| . | . .||...| | ||..||.| .  .|. . . |.||..||| ||| |   .|....     . .  .|. |||||| ||||.  ..| . 
dadkpknyGsvtvtlveskel.edfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

QLLLTqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
. . .        ....| |.||||.  |||..|| |.|...... 
davee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN13_pd Subfamily PTPN13 48-291 9.3e-66 216.9 In-house 29-268 (273) alignment 
Range on Protein: 48-291
Range on HMM: 29-268/273.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSllqEEGHsdYINGNFIRGV--DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYW
.  | . || .||||..|||||.|||.|.   .||   ||| ..|.    .    |||.|||||.|  |||..|||  ..|| |   | |.|. .|.|||
cevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

AQEQ-EPLQTGL-FCITLIKEKWLnEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsGPEPLCVHCSAGCGRTGVLCT
 ... ..|.    . ..|.| . | ..  .|.|.|.    .||| | .|....||| |||||....| .| | ||||     |. |||||| ||.|.| |
Pesknkklkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

VDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.| | .|.  .    .| . ..| |.|.|| . |||..|| | |... ..
idvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN9_pd Subfamily PTPN9 51-289 3.9e-65 214.8 In-house 37-287 (297) alignment 
Range on Protein: 51-289
Range on HMM: 37-287/297.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-Q
   . |..||||.||| ||.||| |. ..|. .||||| ||. |     |.|||||||..|  ||||.|||  | ||.|. | .|.|| .| .|| .| .
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

EPLQTGLFCITLIKEKwLNEDIMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSG-------------PEPLCVHCSAGCG
.  . | . .. .. .  .|| . |.|...   ..|||.|   |..|||| |||||   .| ..|..|. |..                |. |||||| |
ssaefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RTGVLCTVDYVRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
||| ..|.|.  . | ..       ....| ..|.||  ..||.||| | | .| 
rtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 25-292 8.4e-65 213.9 In-house 24-283 (319) alignment 
Range on Protein: 25-292
Range on HMM: 24-283/319.0
VLAGEFSDIQACSAAwkadgvcSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGV
 |. || ...  ..        ..   |..|| .||||...|.||.|||.|| |..   ||||| .|| | .   ..||||.|| .|. ||||.||| ..
llekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

KVILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWLNeDIMLRTLKV---TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG-S
 ...| ..  |... ....|| . ... . | . .|| .|. |. |.. | ||.   . . |.|.| . ||..||| .|| .   .|..... |. .  .
sivvmltklveklkvklkkywpe.enfeeyGrlivtleeeeele.dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
   |. |||||| ||||  ...| . . . . ...     .| .| ..| ||.  ||..|||.|.|... .. 
qsgPivvhCsaGvGRtGtfivldamlervkeegvl....DvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPRG_pd Subfamily PTPRG 27-315 2.4e-64 212.5 In-house 22-310 (563) alignment 
Range on Protein: 27-315
Range on HMM: 22-310/563.0
AGEFSDIQACSAAWKADgvcsTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEE-GHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVK
. || ..| .... . |    . . ..||| ||||| ....||..|| || | .. .. |||| |.| |   | |.|||||||..|. ||||..||  |.
seefealqsetiskdld....aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

VILMACREIENGRKRCERYWAQeQEPLQTGLFCITLIKEKWL----NEDIMLRTLKVTFQKE---SRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
.| |     |.||. |..|| . .|... | . .|||.|. |     . .... ||.  .|.    . |.| .| .||| |||...   | .|. . . .
iivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

GSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYD
 .   |. |||||| ||||... .| . . . .. .     .|... ..| ||.  ||||||| ||. .. ..  |  .. . .  .  .||.|  .
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 56-294 1e-62 206.6 In-house 20-265 (270) alignment 
Range on Protein: 56-294
Range on HMM: 20-265/270.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP-LQ
. . |||.|.||  .|||.|. |.|. .. ||| |..||.||.  .|||..|||| || .|||..||  |. |.|.    |.|||.|||||..|..  ..
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

TGLFCITLIKEK-WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPD------HMLAMVEEARRLQGSG--PEPLCVHCSAGCGRTGVLCTVDY
.    |. ....   .|  .|. |... . |.| .   .| .|||.|||...|      ..|.|... || . .    ||| |||||| ||||.| ..|.
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

VRQLLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQmFCS
. .|| ...      .  .. ..||.|.| ||. |||.|||..|.. ...
avrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavve.yae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 21-293 3.2e-62 205.4 In-house 24-291 (298) alignment 
Range on Protein: 21-293
Range on HMM: 24-291/298.0
REGAVLAGEFSDIQACSAAWKADgvCSTvAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
 . ...| ||  ... |   ...  ... ....||| .|||| |....|..||.|.  ... .|||||  |. . .|. |.||||.||..|. ||||.|.
kkltgyalefqrlnsvsseieee..eke.varkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EFGVKVILMACREIENGRKRCERYWAQEQEpLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
|  ...| |     | .. ....|| .|..  . | . ..| ...    |.. |.|||. .|  ..|.| ||...||||.|||.    .|..... |. |
eedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasq

-GSGPEPLCVHCSAGCGRTGVLCTVDYVR-QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
  .| .|. |.|||| ||.|  . .| |  ..   |..     .|.||  .||.||.|||||||| |.|. | ... 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv....DvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 51-294 3.5e-62 205.3 In-house 41-285 (305) alignment 
Range on Protein: 51-294
Range on HMM: 41-285/305.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQ-
|.. .|..|||.|.. ..|. |.||.  .....||||| ... | ... .||..||||..|. |||||..|. |..|.| .. .|.|...|..||.... 
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

EPLQTGLFCITLIKEKWLNeDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPE-PLCVHCSAGCGRTGVLCTVDYV
|. . | | ..|  ||  . | . | ||...   .||||.| |.|  .||| ||| ..  .| .... .. | .. . || |||||| ||||| ..||  
ekkefgefsvelksektas.dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

RQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
 . | .  .     .|.|. ..|..|. .||| .|| ||.  ....  .
lerlkkEev...vdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPRA_pd Subfamily PTPRA 44-306 8.1e-62 204.0 In-house 48-314 (330) alignment 
Range on Protein: 44-306
Range on HMM: 48-314/330.0
GVCStvAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCER
...   . |. || .|||. ..|||| .||||| .. . .|||||  || |      .||.|||. .|. ||||..||.    |.|     |  ...|..
atle..laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaq

YWAQeQEPLQTGLFCITlIKEKWLNEDIMLRTLKVT------FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTG
|| . .  .  |   .. .... . .|. .| . |.       .|.|| | |. . |||| |||. |  || .... ..|.    .|. |||||| ||||
ywPd.eGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

VLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM--FCST-LQNAS--PHYQNI
 ....| | . . .. .     .|..| ..|.|||  |||.||| |.|... .   .  | |. .|   | |..
tfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkl
subfamily_Ptp69D_pd Subfamily Ptp69D 47-293 1.1e-61 203.6 In-house 39-287 (307) alignment 
Range on Protein: 47-293
Range on HMM: 39-287/307.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
||... . ||  ||||.|. ..|.|||.|. .. . .||||| .||.| . .  .|| |.|.  |. ||||...|  |..| |   . |  ||.|..||.
stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWp

QEqEPLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK-------ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVL
.| .  | |   ..|..|.   .| . |.|.|. .|       .|| | | .|..|.|  || ..  .| ..|..| |.     |. |||||| ||.|..
ie.devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif

CTVDYvrqLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 ..|    ||  .      ..|..| ..|.||.  ||  ||| |||. ....  
valds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 53-294 2.7e-61 202.2 In-house 46-282 (315) alignment 
Range on Protein: 53-294
Range on HMM: 46-282/315.0
RPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEqePL
. ||..|||| ....||..|| | ||. . ||||.| ||| | .    |||.|||.. .. ||||||.|  .  |.|    .|. ....|.||  .   .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kv

QTGLFCITLIKEKwLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  | . .|...|.  |...  ||| |.|... | |.||.| |||| ||| .   .. ..  ... . .   .. |||||| |||| ..|.| | . . ..
iyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

mipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF-CS
       ..... ..|..|  .||. |||.|.| .. . | | 
...naidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 54-290 3.8e-60 198.4 In-house 41-274 (515) alignment 
Range on Protein: 54-290
Range on HMM: 41-274/515.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPL
  | .|||||..||||..||.| ..... ||||.|  .|...|   ||||.|||.. .. ||||||..  |  | |  .  |. . .| .|| .   . .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

QTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLT
. | . . |.  .    . . |.|.|. ...|| | | ..  |||.|||     .| .. | .  .|    || .||||| |||||....|  | .   |
kfGsikvelvslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahaktt

QMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
.|.     .|..| ..|..||  |||.||| |.| .| .
rmv....dvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 47-291 6.8e-60 197.5 In-house 35-276 (315) alignment 
Range on Protein: 47-291
Range on HMM: 35-276/315.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
 . ..  ..| .|||||..||.|..||.| ..... .|||||  .|..||   ||||.||||. .. ||||.|..  |  | |     |. . .| .|| 
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

Q-EQEPLQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-
. . .  . | . ..|.. .  . | . | | .   .||| | | |.  |||.||.     .| .. | .  .|.   .| |||||| |||||....|  
drkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

VRQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
| |.  |...     .|..| ..|..||  |||||.| |.| .| . 
vaqikrtrsv....dvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 51-293 2.5e-59 195.5 In-house 4-243 (250) alignment 
Range on Protein: 51-293
Range on HMM: 4-243/250.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKrCERYWAQEQe
. .|.|  |||| |....|..||.|   . . .|||||  |. | |.. |.|||||||..|. ||||.|.|  ...|.|     |.... ...||  |. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.

PLQTGLFCITLIKEKWlNEDIMLRTLKVTFQKESRS--VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS-GPEPLCVHCSAGCGRTGVLCTVDYVR-
. . |   ..| ...    |.. |.||.. .|.. .  | ||....|||.|||     .|..... .. |   |  |. |.|||| ||.|  ...| |  
aekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
.|   ...     .|.|. ..||.|| ||...||| |.|. . ..  
rlkkekvv....dvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRK_pd Subfamily PTPRK 53-293 4.6e-59 194.8 In-house 40-279 (314) alignment 
Range on Protein: 53-293
Range on HMM: 40-279/314.0
RPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPl
. || .|||..|.|.||..||.|  .... .|||||...| .   . |.|.|||||..|. ||||||.. .   |.|    .|.|| .| .|| .. |  
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

qTGLFCITLIKEKwLNEDIMLRTLKVTF----QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQL
  | . ..|.. . |..... |...|.     |.| | | |.|...||| .|| |   .|..| .    |  .  .. ||||||.||||. ...| | ..
.ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm

LLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ-MFC
. .. .     .| .| ..|....  |.|||||.|.|  . .  .|
ieregv...vdvfnavktlrsrkvnmveteeqykfiydvileaclc
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 55-291 6e-58 191.1 In-house 27-267 (274) alignment 
Range on Protein: 55-291
Range on HMM: 27-267/274.0
ENVRKNRYKDVLPYDQTRVILSLLQE-EGHSDYINGNFIRGVDG-SLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP-
 . .|||||..|| ...||.|.  .  .  |.||| |.|.| |. | ||.|||||||.|. ||||....  |.||.|  .  |. ...|..|. ....  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

LQTGLFCITLI-KEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ---GSGPEPLCVHCSAGCGRTGVLCTVD-YVR
..     . .  ...  ..|  .|.| .  ....|||.   | .|||. .| .....| .|.| .. .        |  |||||| ||||.  ...  ||
iserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
||  ....     .. .| ..| .|   |||.|||......... 
qlreeivv....dvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 42-295 1.6e-56 186.8 In-house 35-291 (325) alignment 
Range on Protein: 42-295
Range on HMM: 35-291/325.0
ADGVCSTVAGsRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAcREIENGRKRC
 ||.  .||. .|||. |||.|.|...|..||.|  ......||||| ...|   .   ..|.| ||..|. |.|||| ..   |...   |...| .||
ddgiakkvam.kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrc

ERYWAQE-QEPLQTGLFCITLIKEKWLnEDIMLRTLKVTFQKE--SRSVYQLQYMSWPDRGVPSSPDHML------AMVEEARRLQGSGPEPLCVHCSAG
  || .|  .  . | . . |.  . .  | . | |.|   |.  .||| |.|..||.| ||.  |  ..        |.|  . .  .  |. ||||||
avywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

CGRTGVLCTVDYVrqllLTQMIP-PDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
 |||||. ..  .    | ..|      .|..| |.||.||. |.| .|| ..|....... | 
vGrtGvfislysa....lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 47-294 4.2e-56 185.2 In-house 43-286 (297) alignment 
Range on Protein: 47-294
Range on HMM: 43-286/297.0
STVAGSRpENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACrEIENGRKRCERYWA
.|||  .  |  |.|||..||||. ||.|  ....  |||.|  |..|.     .|.|| | . |. |||..|..  |..|.|   . ... |.| |||.
qtvaekk.vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln.ddnerdkkcaryWs

QEQEpLQTGLFCITLIKEKWlNEDIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPS--SPDHMLAMVEEARRLQGSGPE-PLCVHCSAGCGRTGVLCT
..    . |   ..|   .   |  . |.|.|| .|    | | | |...|||. |.   |   .| ...| |   ..  | || |||.|| ||||||.|
dkgv.ttfGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

VDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
.| |      .    .  .|..| |.|..||  |||.|||.|.| .| ... |
idsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPN23_pd Subfamily PTPN23 55-290 4.2e-56 184.9 In-house 42-278 (288) alignment 
Range on Protein: 55-290
Range on HMM: 42-278/288.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGV-DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPL
 .. |||..|.||||..|| |     ... ||||  |....  |.  .||||.||. || |||..|.|  ..|| |   . | |.....||| ..  |. 
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

QTGLFCITLIKEKWLNEdIMLRTLKVTFQK--ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARR----LQGSGPEPLCVHCSAGCGRTGVLCTVDYVR
. | . .|| ... ...  . |.||.....  . .||  ||..|||. |||.||...|....|..      |     || |||||| |||||.. |  . 
kfgdlsvtlksvretet.hvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

QLLLTQMIPPdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
. | .. . .   . .|| ..|.||   ||..||..|.|. | .
relekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPN14_pd Subfamily PTPN14 41-292 7.1e-56 184.4 In-house 36-296 (300) alignment 
Range on Protein: 41-292
Range on HMM: 36-296/300.0
KADGVCSTvaGSRPENVRKNRYKDVLPYDQTRVILSLLQEEgHSDYINGNFIRGVDGS--LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGR
..|...||  .. |||..|||.||||||...|| ||  .|. ...|||   |. . |.  . ||..||||..|. |||..||| ||..|.|  .|.|.|.
redallst..aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

KRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVT----FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEA---RRLQGSGP------EPL
... .|. ....  .|  |    . .|. ..  .. | ...      || |.|. |||. |||.|||. ....|  .||    ||   |         |.
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

CVHCSAGCGRTGVLCTVDYvrqLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 |||||| |||||| ..|    |. |     .  .  |. ..|.||   |||  ||.|.|... ...
lvhCsaGvGrtGvlilsdl...liatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 55-293 1.2e-55 183.4 In-house 37-278 (287) alignment 
Range on Protein: 55-293
Range on HMM: 37-278/287.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGhSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
 .|.|||| ||||.|.|||.||   | | ||||| |.. .     |.||.|||.. |. ||||.|.|  . ....  ||.|..|..| .|| . . |.. 
aavkknryadvlPiddtrvllsaegelG.sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GLFCITLIKEKWLNEDIMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSS----PDHMLAM---VEEARrlQGSGPEPLCVHCSAGCGRTGVLCTVDYV
| . ..|.. . .. .   |.|..     .|.| | ||...||||.... .       .| .   .| ||  ..|.  || ||...| ||.|.| ..  .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar..dasevGPlvvhddvGiGrsGillatlvl

RQLLLtQMIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 . |. ..         ||...|..| | ||.  |.|.|| ...  . 
vsrle.dlG..rvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 47-291 3.8e-55 181.8 In-house 37-282 (290) alignment 
Range on Protein: 47-291
Range on HMM: 37-282/290.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEG--HSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
..  |  ..| ..||......||. |..|  ....     .|||  .| |   . .|||||||...|| |||.|.|.  | .|.| . .||.|...|  |
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

WAQEQEPLqTGLFCITLIKEKWLNeDIMLRTLKVTFQKE---SRSVYQLQYMSWPDRG-VPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLC
|....     | | |.|..|. || ... |.|.|. ...   ..|| |.|  .|.. | |.     .|.. |  .    .| ... ||||.. ||..|.|
Wpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfc

TVDY-VRQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
...  . .   .. |     .|.|. ..| |.|  |||..||..... | . 
aaattinkcktegvi....dvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPRN_pd Subfamily PTPRN 41-291 5.7e-55 181.1 In-house 42-291 (297) alignment 
Range on Protein: 41-291
Range on HMM: 42-291/297.0
KADGvCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRK
.|.  ... ......||.|||.|.|||||..|| |.  ... .|||||  .|   |    |||||||||..|. |||..||| || ||.. .|  |.| |
eaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

RCERYWAQEQEPLQtGLFCITLIKEKWLNEDIMLRT--LKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTG
.|.||| .| . .  ... . |. |.   .| ..|.  ||   ..|.|.| |. ..|||..|||.|.  .| .     .       |. ||||.|.||||
qckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtG

VLCTVDYVRQLLLTQMIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
| . .| | . ||  .   .  .   . ..| |||  |.|..|..| . .||. 
vyilidlvlnrllkGvk..eidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN1_pd Subfamily PTPN1 48-290 9.2e-54 177.1 In-house 24-269 (290) alignment 
Range on Protein: 48-290
Range on HMM: 24-269/290.0
TVAGSRPENVRKNRYKDVLPYDQTRVILsllqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ
| .  .|||  .|||.|| ||| .|..|    |... |||| ...   .    || ||||||.|   ||..|||   | ..|  . .|... .| .|| |
treaklpenrnlnryrdvspydhsrikl....eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

EQE--PL--QTGLFCITLIKEKWlNEDIMLRTLKVTF--QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS--GPEPLCVHCSAGCGRTGVL
..|   |  .   . ..||.|.  ..  ..|.|...    .|.|....  |..||| |||.||  .| .. . |.         |  .||||| ||.| .
geeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

CTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
| || .  |.  .       . .|.|..||.|   .|| .| || | .. .
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 54-292 1.5e-53 176.6 In-house 45-278 (287) alignment 
Range on Protein: 54-292
Range on HMM: 45-278/287.0
PENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEpLQ
..|  |||....|..|. ||.|     . | ||||  || |   . |.|....|. .|. .||.|...  |..|.| |.| || .. | .||..|.  . 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

TGLFCITLIKEKwLNEDIMLRTLKVTFQK---ESRSVYQLQYMSWPDRG-VPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLL
 | . |.|..|.  |.. . |.|.|. ..   . ..| | |. .|...| |..    .| . |  .  . .|  .. ||||.. ||....| ..   .  
lGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

LTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 |. .     .|.|. ..| |.| .||| |||.|... | .. 
kteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-292 1.2e-51 170.9 In-house 59-293 (319) alignment 
Range on Protein: 54-292
Range on HMM: 59-293/319.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengRKRCERYWAQEQEP-L
..|  |||. ..|..|...| |  |. |  |||||  |. |      |||.||||. || ||||..||. .  |..        ...| .|| .. .   
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

QTGLFCITLIKEKwlnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHCSAGCGRTGVLCTVDYVRQ
. .   .....|    .. ..| ....    .|. |.. |  .. ||| ||| .|  .. .|.  | |.    ..... ||||||.|||||  ..| . .
erfkvkvdsveet...aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

LLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ--MF
 .  .       ....|  .|.||.  ||   || |.| .. .  .|
rmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 54-292 2.4e-51 169.9 In-house 23-257 (284) alignment 
Range on Protein: 54-292
Range on HMM: 23-257/284.0
PENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengRKRCERYWAQEQEP-L
..|  |||. ..|..|...| |  |. |  |||||  || |      ||||||||. || ||||..||. .  |..        ...| .|| .. .   
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

QTGLFCITLIKEKwlnEDIMLRTLKVTF---QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--SGPEPLCVHCSAGCGRTGVLCTVDYVRQ
. .   .....|    |. ..| ....    .|. |.. |  .. ||| ||| .| .....|.  | |.    ..... ||||||.|||||  ..| . .
erfkvkvdsvees...eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

LLLTQMippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ--MF
 .  .       ....| ..|.||.  ||   || |.| .. .  .|
rmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
0041856 (Phosphotyrosine protein) phosphatases II 56-292 7.3e-51 167.7 In-house 1-171 (182) alignment 
Range on Protein: 56-292
Range on HMM: 1-171/182.0
NVRKNRYKDVLPYDQTRvilsllqeegHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACreiengrkrCERYWAqeqeplqtg
|. ||||.|.||||..|          ..|||| |...|   .  .|||||||..|. ||.|...| |...|....         .|.||.         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lfcitlikekwlnedimlrtlkvtfQKESRSVYQLQYMSWPDRGVPSsPDHMLAMVEEARRlqgsGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmip
                         ... | ..|..|..||| |||. .|..|...||...     ..|  ||||||.||||.|.  .....|       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

pDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
 ..||...|  .|..|| .|.|..||.||.  . ...
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 21-290 3.2e-48 159.1 In-house 17-234 (392) alignment 
Range on Protein: 21-290
Range on HMM: 17-234/392.0
REGAVLAGEFSDIQACSaawkadgVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
|  |....|| |.           .  . .. .. |..|||||..||||..||.| ....  .|||.|  .|...|   ||||.||| . .| ||||.|.
rhsalffeefhdlpgpd.......iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

EFGVKVILMACReIENGRkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGS
.. |  | |  . ...|                                            .. |.| | ..  |||..||     .| ...| .   |.
qenvttiamvtk.lkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

GPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQ
   || .||||| |||||. ..| |      |.|.     .|..| ..|..||  |||.||| |.| .| .
ythpliihcsagvgrtgvvisidsvvahakktrmv....dvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 56-288 7.2e-47 154.4 In-house 56-279 (290) alignment 
Range on Protein: 56-288
Range on HMM: 56-279/290.0
NVRKNRYKDVLPYDQTRVILSllqEEGHSDYINGNFIRGVDGslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPLQT
...|||||||   |.|||||.   . .. ||.  |...|..    .| |||.|  | .|.||.| . .| .| | |  ||.|. .||.|. . | | |  
efkknrykdvvcndktrvilk...dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GLFCITLIKEKWLNEDIMLRTLKVTFQKESR--SVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsgpePLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
| . ..  .|.  ...|...|| |  ... .   .. |. .||||. |. |   .| ..   |.. |    |. |||||| |||| . ...   |.||  
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldG

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
    .. | |.|  .|. | ..|| . ||  | . .
k...eldlldlvralrnsrlnsvqvdiqylalveil
0051429 (Phosphotyrosine protein) phosphatases II 83-296 5e-46 152.8 In-house 3-229 (272) alignment 
Range on Protein: 83-296
Range on HMM: 3-229/272.0
HSDYINGNFIRGVdgsL------AYIATQGPLPHTLLDFWRLvWEFGVKVILMACREIENGRKRCERYWA-----------QEQEPLQTGLFCITLIKEK
 |.||| ... |           ......||||.|  ||||| .| |.|.|.. ..| | ||  |.|||.            . ..   | ...||..|.
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

wLNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPdhMLAMVEEARRlqgsgPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFS---
 | .|..||.| .|     .|.| |..|.|..|||.|||...  .|...|. ..     ..|. ||||||..|||... .... . .  . |  |.    
.llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--LFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTL
  |...| ..|.|||.||||||||.|||. ......| |
lyleeaveelraqrpgavqteeqylflyeallellrsll
0049772 (Phosphotyrosine protein) phosphatases II 48-290 1.1e-45 152.1 In-house 38-278 (314) alignment 
Range on Protein: 48-290
Range on HMM: 38-278/314.0
TVAGSRPENVRKNRYKDVLPYDqTRVILSLLQEEGhSDYINGNFIRGVdgsLAYIATQGPLPHTLLDF----------WRLV--WEFGVKVILM------
..... ..|  ||||.|.||.| .||||. |  .| ||||| ....|.   |..|||||||..|. ||          ||.|  ... | .| |      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------ACREIENGrkrcERYWAQEQEPLQtglfcitliKEKWLNEDImlrtlkvtfqkeSRSVYQLQYMSWPDRGVPsSPDHMLAMVEEA
                ..  .||      ..|...| |.         .| . .|.             .| .... .. .|| ..| .........|  
adelsrLdaAlgKtpllildgng....neptaadlellk.........eelydpelf............erlgikylripvpDgsap.lledfdeflefi

RRLqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLltqmippDFSLFDVVLKMRKQRP-----AAVQTEEQYRFLYHTVAQ
...  . ..|. |||.||.||||......|.  ||       ..|| ...  .|..||      .... ||| | .. . .
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealle
0043147 (Phosphotyrosine protein) phosphatases II 82-286 5.8e-45 148.4 In-house 3-155 (172) alignment 
Range on Protein: 82-286
Range on HMM: 3-155/172.0
GHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlKVTFQ
..||||| ... ..     .|||||||..|| ||||...| |...|......                                            .. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

KESRSVYQLQYMSWPDRGVPsSPDHMLAMVEEARR-LQGSGPEPLCVHCSAGCGRTGVLCTVDYVRqllltqmipPDFSLFDVVLKMRKQRPAAVQTEEQ
...|...|..|..||| ||| .....| ..|  .. |. |  .| .||||||.||||.|.  ....          ..||...|  .|..|| |||...|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YRFLYH
|||||.
yrflyy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 49-292 1.2e-44 147.2 In-house 33-293 (301) alignment 
Range on Protein: 49-292
Range on HMM: 33-293/301.0
VAGSRPENVRKNRYKDVLPYDQTRVILSLLQE--EGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
. | . || . ||.|.. .||. |.||.  ..    . .||| ..| |.  . ..||.|||. .|| |||||.|.  .  |.| . . |. ...||.|| 
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywp

Q-EQEPLQTGLFCITLIKEK----------------WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEA-RRLQGSGPEPLCVH
. |.|  . | | .||..|.                  |.  . |..||. .|.|..| |||  .||. ||   |  .|  ...   | |  |  |. ||
nseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVH

CSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
||.. .|.|| |.|.        . .     .|.|.  .|...| ||.| ||| ..|  . ...
CSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 56-288 1.3e-44 147.2 In-house 7-236 (239) alignment 
Range on Protein: 56-288
Range on HMM: 7-236/239.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplQT
|  |||| ... ||..||.|  | .. |||||| ...|  |||  ||||||| .  .  ||||..|.    ||.|    ||  .|.| .|| .     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

GLFCITLIKEKWLNeDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  . .|| | . .  | ..||. .    | | | ||| ..  |||.|||     .| .  .  .    |  |  .||||| |||| .  .| . .    |
cnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
       .|. |  .|..||  ||| ||| |.. .|
k...tvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 56-288 1.4e-44 147.1 In-house 8-237 (239) alignment 
Range on Protein: 56-288
Range on HMM: 8-237/239.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplQT
|  |||| ... ||..||.|  | .. |||||| ...|  |||  ||||||| .  .  ||||..|.    ||.|    ||  .|.| .|| .     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

GLFCITLIKEKWLNeDIMLRTLKV--TFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQ
  . .|| | . .  | ..||. .    | | | ||| ..  |||.|||     .| .  .  .    |  |  .||||| |||| .  .| . .    |
cnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

MippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
       .|. |  .|..||  ||| ||| |.. .|
k...tvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 55-288 1.8e-44 146.8 In-house 2-235 (237) alignment 
Range on Protein: 55-288
Range on HMM: 2-235/237.0
ENVRKNRYKDVLPYDQTRVILSllQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQ
||  |||| ..  ||..||.|      . ||||| ....|.||.   |||.||||  .  |||..||.    ||.|    ||. ...| .|| . ..|  
enkiknrygnivaydhsrvvlk..gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

TGLFCITLIKEKWLnEDIMLRTLKVTFQ---KESRSVYQLQYMSWPDRGVPSSPDHMLA----MVEEARRLQGSGpePLCVHCSAGCGRTGVLCTVDYV-
 | . ..| |.. .  |  .|.| .. .   || | ..| |. ||||||||     .|     ...... .. ||  |  .||||| ||||..  .| . 
ygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg..pwiihcsagvgrtgiflvidaml

RQLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV
||    ...     ... |  . ..||  .||..|| |...|.
rqakekkvv....diynyvysieedrpyiiqtkdqyvfihqti
0046846 (Phosphotyrosine protein) phosphatases II 78-291 8.5e-44 144.7 In-house 6-172 (176) alignment 
Range on Protein: 78-291
Range on HMM: 6-172/176.0
LQEEGHSDYINGNFIRGVdgslAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQtglfcitlikekwlnedimlrtlk
| .....||||.|.| |     ..||||||||.|| ||.....| |...... . |.| || .| .|| .....                          
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

vtfqkesrsvyQLQYMSWPDRGVPSSpDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQllltqmiPPDFSLFDVVLKMRKQRP-AAVQ
           | ... ||| |||.. ...| ..|. |. . .| .|  ||||||.||||.|.  . ..          ..|..... ..|.|||  |||
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavq

TEEQYRFLYHTVAQM
|.|||||||. . ..
tpeQyrflyefelll
subfamily_CG7180_pd Subfamily CG7180 50-293 3.4e-43 142.4 In-house 36-291 (296) alignment 
Range on Protein: 50-293
Range on HMM: 36-291/296.0
AGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRkRCERYWAQEQ
.| | ||  |||. .|.|||..||.|. |. | .|||||  .. .     .|| |..|  .|. .|||||.. ... . . ... .  .  .  || ...
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

ePLQTGLFCITLIKEKWLNeDIMLRTLKVTFQ------------KESRSVYQLQYMSWPD-RGVPSSPDHMLAMVEEARRLQGSG-----PEPLCVHCSA
   | | . . ...|| .  ..  ||.|.| .             | | | ..|.  |.    ||.|   .. ... .| ...        .|..|..| 
.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssd

GCGRTGVLCTVDYVRQLLLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
| .|.|| ...|   .|.  .     . .|. | ..|..||  |.. |.|...| .. ... 
GasRsGvylaidanlelveke...eevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0036282 (Phosphotyrosine protein) phosphatases II 84-285 4.9e-43 142.1 In-house 2-163 (174) alignment 
Range on Protein: 84-285
Range on HMM: 2-163/174.0
SDYINGNFIRGVDGSLAYIATQGPLPhtlldFWRLVWEFGVKVILMACREIENGRKRCERYWAQeqeplqtglfcitlikekwlnedimlrtlkvTFQKE
||||| ... ..  .  .||.||||.     ||....|.|.....| ..|.|.|. .| .||                                 . . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRSVYQLQYMSWPDRGVPSSPDhMLAMVEEARRLQGS-GPEPLCVHCSAGCGRTGVLCTVDYVRQLLLtqmiPPDFSLFDVVLKMRKQRPAAVQTEEQYR
.|...|..|. |||.|||...  .| .|..... . . .  |. ||||||.||||.|.  ... ..||    ..    .|.| ..|.||| .|||..|||
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyr

FLY
|||
fly
0049260 (Phosphotyrosine protein) phosphatases II 91-285 1.2e-41 137.2 In-house 1-143 (152) alignment 
Range on Protein: 91-285
Range on HMM: 1-143/152.0
FIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyQL
|| |.  . ..||||||.|.|| ||||...| |...|.| ... |.|.  ||.|.                                           | 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRqllltqmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLY
... ||| |||......| ...  ..|. .  .|  ||||||.||||.|.  ....          ..||...|  .|..|| ||....|.||||
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 37-295 3.5e-41 136.2 In-house 25-280 (307) alignment 
Range on Protein: 37-295
Range on HMM: 25-280/307.0
SAAWKADGVCSTVAGSrpeNVRKNRYKDVLPYDQTRVILSLlqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIEN
 | .. .||      .   |  ||||.||   |..|... .  .   ||||  |..        .|..||||  |  .|| .. .  |. ..| |. || 
lakktpegvtveafsa...ntdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

GRKRCERYWAQEQEPLQT-----GLFCITLIKEKWLNED---IMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVH
.. .||.||  |.   ..        ... .  | |  |   | . |||| . ..||.. .||.  |||||||      . ..|  |  .    .|. ||
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....npvvvh

CSAGCGRTGVLCTVDYVRQLLLTQMIPPDfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
|||| ||.| . .. .|.. ... .   |  . ..| ..|.||. |.||| || .|.  . . |   
csaGvGrsGtivaislvqdkmiaGinckd..mkklveelrsqrhyaiqteaqylylhrvlleyflel
subfamily_ptpA1_pd Subfamily ptpA1 44-242 1.3e-40 134.4 In-house 35-249 (418) alignment 
Range on Protein: 44-242
Range on HMM: 35-249/418.0
GVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGsLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCER
|   |  | .  |  |||| ..|| ..||| |  .|..  ||||| |.| |      .|.|||||| |. ||||.|||  ...|.|  || || | .|.|
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWAQEQEPLQ----------TGLFCITLIKEK-WLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE--AR--RLQGS--GPEPLC
|| ..    |           | . . |..     . .|. | ...||. |.| . | ||  |||. .|   . .  ..     |  ..  |     |. 
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGCGRTGVLCTV
|||||| |||| .|| 
vhcsagvgrtgtfcta
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 48-302 5.9e-40 131.9 In-house 25-277 (283) alignment 
Range on Protein: 48-302
Range on HMM: 25-277/283.0
TVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEeghsDYINGNFIR---GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERY
..  |  || ||||.....|.|| || |  . .    ||||  ||      . .  ||..|.|| .|  |||..|..  .  |.|  .  |. |..| .|
adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WAQEQePLQTGLFCITLIKEkWLNEDIMLRTLKVTFQ---KESRSVYQLQYMSWPDRGvPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLC
| ..    . | | .|| || . ..  . . | .  .   |..  .   |.  | . | . ..   |  ..  . ||   .  |. ||||.| |||.|..
WPkrG.sedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

TVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTV-AQMFCSTLQNASPH
..    . .||. .     .| ||  ||.||. |||| .||..... |  | .|   | |   
aasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 55-293 1.2e-37 124.2 In-house 54-290 (305) alignment 
Range on Protein: 55-293
Range on HMM: 54-290/305.0
ENVRKNRYKDVLPYDQTRVILsllQEEGHSDYINGNFIRG-VDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ---EQE
 .. ||||.||   ||. | |   ..   ||||  |..   .     .|..|||| .|. .|| .| .  |. |.| |. .| |. .| .||     |. 
iaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

PLQTGLFCITLIKEKWLNED--IMLRTLKVTF-QKESRSVYQLQYMSWPDRGVPSSpdhMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQ
 |..|.    .   | .. |  | . .|..|.  ... || .||.  |||||||      |. .|    ..||   |. |||||| |||| . ...|. .
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc...kltslellsairgsk.vpivvhcsagigrtgtivaieyile

LLLTQ-MIPPdfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
 .  .   ||   . ..|  .| ||  ..|.. || |..  . . | 
kiaenkpcpp...mpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 13-289 1e-35 118.1 In-house 9-276 (439) alignment 
Range on Protein: 13-289
Range on HMM: 9-276/439.0
ERLEARGGREGAVLAGEFSDIQACSAAWKADgvcsTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTL
| .|     .  ..  .|  |.. |  ....    .   ..  .  ||||||| ..| |||.|  .    || ||| |.|.|      |||||||  .| 
ehvekldknkqeifkeifekinstspdyaci....aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

LDFWRLVWEFGVKVILMACREIENGRkrcerYWAQEQEPLQtGLFCITLIKEKWLNeDIMLRTLKVTFQ----KESRSVYQLQYMSWPDRGVPSSPDHML
 ||||||.|  .  |.| .  .|  .     ||  ..|    |  ..   ..  |  . ..| .||  .    .  |.| |..|..|||. ||.   |.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy.gdiavrvdrnielp.nyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

AM---VEEARRLQGSGpePLCVHCSAGCGRTGVLCTVDYVR-QLLLTQMIppdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 .   .. |   .  |  |. |||||| |||| . ..|    || | . .     .  .|  .||||   ||.  || |.| .| 
dflrainsandkeeyg..pvvvhcsagvGrtGtiialdialeqlklenkv....dikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 50-288 1.1e-35 117.7 In-house 31-265 (281) alignment 
Range on Protein: 50-288
Range on HMM: 31-265/281.0
AGSRPENVRKNRYKDVLPYDQTRVILSL-LQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE
.  .| | .|||| ..   | .|| | . . ..  .|||  |.||       || ||||   |  ||||..|.     |.| |. .|  |..|  |. ..
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

QE-PLQTGLFCITLiKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLqgSgpEPLCVHCSAGCGRTGVLCTVDYVRQ
    ||   . ..  ..  .|. ..   |..... |.| . .  .  |||  || | . || .. . |    |   |  .||||| ||.| | .|.   |
ahcclqfdklsvsy.edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar..s..tppvihcsagvgrsgtlmaveialq

LLLTQMIPPDFSLFDVVLKMrKQRPAAVQTEEQYRFLYHTV
 . ...  ||       |..   | |.||| .|| .... .
sihshftlpdikqivshlrv.tgraasvqtlqqymliwkvl
0044763 (Phosphotyrosine protein) phosphatases II 67-286 1.1e-35 118.3 In-house 1-165 (178) alignment 
Range on Protein: 67-286
Range on HMM: 1-165/178.0
PYDQTRVILSLLQEEGHSDYINGNFIRGVdgslAYIATQGPlphtlLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEplqtglfcitlikekw
|.| |||.|| |. .  ||||| ..| .      |.....|      |...|..| |...|.. . |.|.|.  | .|| .| .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

lnedimlrtlkvtfqkesrsvYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippDFSLFDVVLK
                     .| ... .|| |||....|.|..||  .... . ..|  |||||| ||.|.|.  .....|        ..||....  
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRKQRPaAVQTEEQYRFLYH
.|..|| .|....|.|.|| 
vrerRp.ivpnpgqlrqLye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 51-204 1.3e-35 117.7 In-house 28-183 (297) alignment 
Range on Protein: 51-204
Range on HMM: 28-183/297.0
GSRPENVRKNRYKDVLPYDQTRVilSLLQEEGHSDYINGNFIRGVD--GSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-
  |.  .|||||.|.| .|.|||   ||.    .|||| ...   |    | || .||||  |. |||.||.| .|.|| | ..  |.||..|  || . 
akrnsslrknryrdilatddtrv..kllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EQEPLQTGLFCITLIKEKWLN-EDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSP
.|| |..| . .  . .   . . ..|  |.. ...||| |   |..|||| ||||  
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 56-292 4.4e-34 112.8 In-house 35-270 (285) alignment 
Range on Protein: 56-292
Range on HMM: 35-270/285.0
NVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIR--GVDGSlAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPL
|   ||| ||   ..|||.|     .   |||  ...|  | | | .||.|||||| || |||.....  .  .|| |  .| | ..|  |. ..  | .
npdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

QTGLFCITLI--KEKWLNEDImLRTLKVTFQKE--SRSVY--QLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSgPEPLCVHCSAGCGRTGVLCTVDYVR
. | . |||   ||. .   | | .| |.  ..  |  .|  ..|   |||.  |     |. . .  ....    .|.||||||| |||  .  .||  
kfgkyeitlteckeeaiagti.lnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyat

qllLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF
   .  |  |.  ..|.| .||  |  |||.  |. |||  . . |
...irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 59-284 7.9e-33 108.5 In-house 53-273 (301) alignment 
Range on Protein: 59-284
Range on HMM: 53-273/301.0
KNRYKDVlPYDQTRVIlSLLqEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPLQTGLF
|.||. | | . .  .  .. ..|.   |  |.|     .  .|||||||. |  ||| ..  . |. | | ....|.  ..|| | ... .| |. | |
khryptv.PckPstav.evi.vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

CITLIKE-KWLNEDIMLRTLKVT---FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRlqgsGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQm
 |.. .. . ||..|. |||.|.    . ..|.|   ||..|.||||| |  ..  ..| ...      .|. |||||| ||.  . . .|. . .... 
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylarevead.

ipPDFSLFDVVLKMRKQRPAAVQTEEQYRFL
  |   | . . ..|..|  .|||..|  ..
..ptieltealkhlrehrwngvqtnsqlywm
0051082 (Phosphotyrosine protein) phosphatases II 84-287 4e-32 106.2 In-house 3-148 (151) alignment 
Range on Protein: 84-287
Range on HMM: 3-148/151.0
SDYINGNFIRGVdgslaYIATQGPLPhtllDFWRLVWEFGVKVILMACREIENGrkRCERYWAQEQeplqtglfcitlikekwlnedimlrtlkvtfqke
||||| ... |      .....|||.    ||..|..| |.|.|.. . | |.|   | .|. ...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRlqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippdFSLFDVVLKMRKQRPAAVQTEEQYRF
 . |.......||| |.| |.| .|...|....    .. |. ||||||.||||.|. .. . .          .||....  .|..|| .||...|..|
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqflf

LYHT
... 
qlfa
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 55-298 4.3e-32 105.9 In-house 51-295 (310) alignment 
Range on Protein: 55-298
Range on HMM: 51-295/310.0
ENVRKNRYKDVLPYDQTRVILSLlQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
... |||| ||.  |..|| | . .   . |||  |...      ..| .|||| ||..||||....   . ||. |.  |.|| .|  ||         
kymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GLFCITLIKEKwlNEDIMLRTLKVTFQKESR------------SVYQLQYMSWPDRGVPSSPDHMLAmveeARRLQGSGPEPLCVHCSAGCGRTGVLCTV
|   .| . |    |.. .  | |||  .               |  ...  |||||||    | .      | |      |  |||||| .|..|....
gcirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvval

DYVRQLLLTQmIppDFSLFDVVLKMRKQRPAAVQTEEQYRFLyHTVAQMFCSTLQN
..  . |          . .|. ...|.|   .||| || .. . |  .|. . ..
klkidkldrg.l..kvdaeevktellksraiciqtelqylii.drvriifargete
PTPc_DSPc_SM00012 187-289 6.9e-31 101.9 In-house 2-104 (105) alignment 
Range on Protein: 187-289
Range on HMM: 2-104/105.0
VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP--EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFL
|....|..||| |||...|..| .... .. .      .|..||||||.||||.....|.. | | ..     ...|..| ..||||| .||||||| ||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YHTVA
|. ..
yrall
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 47-291 1.6e-29 97.7 In-house 23-258 (267) alignment 
Range on Protein: 47-291
Range on HMM: 23-258/267.0
STVAGSRPEN-VRKNRYKDVLPYDQTRVILSLLQEEghsdYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENgrkRCERYW
||.. | .|.   .||. |.||||.|||||.  .||    |||  .. |     |.|.||.||  |  ||. .. . .| || .  .  ..      ..|
stisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfw

AQE---QEPLQTGLFCITLIKEkwlNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTV
  .    .  |      .| ||   ..|  . ||.. |..||     | |    .  .   |     .   |.     |  || |.||.| ||.| . ..
PPkmgqakkyqdltvehsleke...endyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvi

DYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
|   . . |. .     .|| ..|.|.||.. |.| |.| ......|. 
dsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-291 2.6e-28 93.9 In-house 42-270 (288) alignment 
Range on Protein: 55-291
Range on HMM: 42-270/288.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA-QEQEPLQ
.|  ..||...   | ||| ||    .    ||. | .         | .| ||  |.  .|... | .|. |.| |. .| |... . |.  .  |  .
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

TGLFCiTLIKEKWL--NEDIMLRTLKVTFQKESRS-VYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQlll
 | .| | .|.|    .  . . .|... . | .  | .| .  |.| ||| .    | ..|  . ||    .|. ||.||| |||| |  .  . .   
igrlc.tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililiale...

TQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
.  .. . ..  .. |.|..|  |.||| || ...  | . 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_CG42327_pd Subfamily CG42327 56-216 2.6e-28 93.6 In-house 28-192 (319) alignment 
Range on Protein: 56-216
Range on HMM: 28-192/319.0
NVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGS-LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
   |.|. .|.|  .|||.|    .. .. |.. ...|| | .   |||.| .|  .  ||||.|||   .||. ..   |.| |.| .|.  ..   .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

GL---FCITLiKEKWLNEDIMLRTLKV--TFQKESRSVYQLQYmSWPDRGVPSSPDHMLAMVEEARR
 |   . .|| |..  ..  .. || .    ..||| .    |  |.. .||...  ..||. |.| 
slyGdilvtl.kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
0048076 (Phosphotyrosine protein) phosphatases II 174-290 8.8e-27 88.9 In-house 34-141 (145) alignment 
Range on Protein: 174-290
Range on HMM: 34-141/145.0
RTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRQllltqmipPDFSLFDVVLKMRKQRPA
 .|  ... ..| ..|..|..|||.|||......|...|  .... .| .|  ||||||.||||.|.  . ...         ..||.... ..|.||| 
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsqrpg

AVQTEEQYRFLYHTVAQ
||....|.||||  . .
avpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 169-286 6.8e-25 82.9 In-house 48-139 (144) alignment 
Range on Protein: 169-286
Range on HMM: 48-139/144.0
EdimlrtlkvtfqkesrsVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGpEPLCVHCSAGCGRTGVLCTVDYVRqllltqmiPPDFSLFDVVLKMR
|                 ..|.....|||.|||......|...|  .... .| .|  ||||||.||||.|.. . ..          ..||....  .|
e.................giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvr

KQRPAAVQTEEQYRFLYH
..|| ||....|.|||. 
srrpgavpnpgqlrfLle
subfamily_egg_pd Subfamily egg 55-299 1.6e-23 77.9 In-house 39-277 (307) alignment 
Range on Protein: 55-299
Range on HMM: 39-277/307.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENgrKRCERYWAQ-EQEPLQ
.|  | | | |   | .|| | | .     |.|  | ..|      .| .| ||  |  ||||.|..  |. |.|     |.  .||| || . |...|.
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

T--GLFCITLIKEKWLnEDIMLRTLKVTFQKESRSVYQLQYMSWpDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLLLT
|  | . |. .| .    | ..|  |.      .    |..  . |    |     | ..  .|.|     .|  |..  |. ....| ...     || 
tvpGslrienlkvdsk.adplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnls....kpvvvqdilGvskaatlvaieiallsllr

QMIpPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
  |   . .   |  .|..|. .|..  .| |.|  |. .|   . .|
Gpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 60-295 3.9e-23 76.6 In-house 47-279 (312) alignment 
Range on Protein: 60-295
Range on HMM: 47-279/312.0
NRYKDVLPYDQTRVILSllQEEghSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-------EQEPL
||| ..  .|. |  |.   .|    ||  ||.. .     ...|||||  |   ||.|.  .|   |.. |  .|.| ..| .| ..       |.  .
nrypniqcwdrgrftla..gde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

QTGlFCITLIKEKWLNEDIMLRTLKVTFQK---ESRsVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDyvrQLL
 |  .|  .      .. |  | |||  .    ||. . . |. |||| |.| | |  | ..   .. .     |.  ||||| |||| |. ..    ..
yte.ycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlalie...smi

LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
 .   |    . |. . .||.|  .|..  || .  ..| ... | 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 56-147 7.2e-23 75.9 In-house 47-152 (350) alignment 
Range on Protein: 56-147
Range on HMM: 47-152/350.0
NVRKNRYKDVLPYDQTRVILS--LL------QEEGHSDYINGNFIRGV------DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRC
   |||||..|||...||.|   |            .|||| |...        . .  |||||.||| |. ||.... . .|||||.   ..|.....|
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

ERYWAQ
.||| .
yrYWqe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 183-292 2.5e-20 67.5 In-house 184-287 (305) alignment 
Range on Protein: 183-292
Range on HMM: 184-287/305.0
ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGsgpePLCVHCSAGCGRTGVLCTVDYVRQLLL-TQMIpPDFSlfDVVLKMRKQRPAAVQTEEQY
..| | .  .. |||||||..   .| ..|.|| ..|    |. |||||| |||| .  ..|. . ||  |.|  |     .. |.|.||  ..||..||
karkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmleyildqllagqii.edtd..kilqkireqrnnsiqtdaqy

RFLYHTVAQMF
 |..  . ..|
lfvhqvilnyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 69-299 3.5e-20 67.3 In-house 31-266 (290) alignment 
Range on Protein: 69-299
Range on HMM: 31-266/290.0
DQTRVILSLLQEEGHSDYINGNFIRGVDGsLAYIATQGPLPHT-------LLDFWRLVWEFGVKVILMACREIENGRK----RCERYWAQEQE-PLQTGL
 .|||.|    .   .|||  |..   .| |. |.|| |. ..       . .|| .. .  || . | |   |. ..     |..|  .. .  |. . 
eatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

FCITLiKEKWLNEDIMLRTLKVTFQKES-RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARrlqgSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMip
. .   |.|  ..|.  |.| |.|..|    |   .. .| .. |. ..  .|....  .        |  |||  |  |  .| ...   |..  .   
ltvkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaets..

PDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNA
 ...| ||. ..||||  |....... |    .  ..  .|.. 
gsvkledvlkalrkqralaitsalelafvdagivllaievldqf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 107-289 4.5e-19 63.0 In-house 99-285 (302) alignment 
Range on Protein: 107-289
Range on HMM: 99-285/302.0
PLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQE-QEPLQTGLFCITLIK-EKWL-----NEDIMLRTLKVTFQK----ESRSVYQLQYMSW
|   ||  .| |. .. | ..   |  .|.. |.|  |.... .. |. | .... .. .. |      ....| |.... .|      ..|  |.. .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDRGVPSSPDHMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPpdfSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
|| | |  ... | ..      .    . . |||||| |||| | .. |  || ... .     | ..|| .|. |  |||.|.|  .|   |.
pdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliylllcvt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 183-290 1.1e-18 61.9 In-house 87-192 (440) alignment 
Range on Protein: 183-290
Range on HMM: 87-192/440.0
ESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ-GSGPEPLCVHCSAGCGRTGVLCTVDYVrqlLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQY
|||.. | .| .|||.|||     .| |...    |  .|  || ||||||.|||||. .|| .   |       .  .| ..  ||..||  ||| |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsi...lreakrsdqidifsfinsmrnnrpqmvqtpeqy

RFLYHTVAQ
 |....| .
afvheavle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 185-293 2.8e-18 60.8 In-house 215-345 (350) alignment 
Range on Protein: 185-293
Range on HMM: 215-345/350.0
RSVYQLQYMSWPDRGVPSSPDHMLAMVE----------EARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQ-LLLTQMIPPDFS-----------LFD
  |||||.  |.| ..   |  .| ..|              |. .  .|. ||||||.||||.|.|.|.. . ..  ...  ..            .. 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

VVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
.|...||||   ||. .|. |.|...  .| 
ivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 111-307 7.2e-18 59.6 In-house 40-235 (255) alignment 
Range on Protein: 111-307
Range on HMM: 40-235/255.0
TLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTgLFCITLIKEKwLNEDIMLRTLKVT--FQ--KESRSVYQLQYMSWPDRGVPSSPDH
|.  |.. .   . .|. | |   |.|...|..|.  |..  .  |  ....  |    |..||||..|  .   |. . |   .|  |...  |  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

MLAMVEEARRlqgSgpEPLCVHCSAGCGRTGVLCTVDYVRQLL---LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFcSTLQNASPHY
.| ..  .|    |   .. ||||.| ||.  .  ...| | .   | .    ..    .. ..|..|..|..|  |  |   .| ...    ..   .|
ilnilkvvrd...s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgeleaky

QNIK
|.|.
qeir
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 55-291 9e-17 55.6 In-house 46-278 (303) alignment 
Range on Protein: 55-291
Range on HMM: 46-278/303.0
ENVRKNRYKDVLPYDQTRVILSllqeegHSDYINGNFIRgVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQT
.|. |||. ||.  |...| ||       | ||  ...  .| |   | || ||.||  |||... |  ||..|.   . |  .   .  . ..|. |. 
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GLFC--ITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSS--PDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDYVRQLL
      .  .|.  | .   |. | |.  .    ..  .| .||   .||   |  .  . .    |.   . .|      .||||.| ..  .     |
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

LTQmiPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM
 ..   . . |  .. ..|. |  |||   |. ..|  .|. 
hse..qasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_hpo-7_pd Subfamily hpo-7 110-308 3.4e-16 53.9 In-house 45-245 (263) alignment 
Range on Protein: 110-308
Range on HMM: 45-245/263.0
HTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTgLFCITLIKEKWLNeDIMLRTLKVTF----QKESRSVYQLQYMSWPDRGVPSSPD
 |.  |.. .   . .|. | |   |.|...|..|.  |..  |  |  ...   |  . |..|.||...     .|. . | . .|  |...  |  . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.lanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

HMLAMVEEARRLqgsgpEPLCVHCSAGCGRTGVLCTVDYVRQLL---LTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST--LQNAS
 .| ... || .      .| ||||.| ||.     .. | | .   | .    ..    .. ..|..|..|..|  |  |   .| ...      ....
eilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgele

PHYQNIKE
 .||.|..
akyqeirk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-286 3.9e-16 53.8 In-house 3-198 (199) alignment 
Range on Protein: 97-286
Range on HMM: 3-198/199.0
GSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQE-PLQTGLFCITL---IKEKWLNEDIMLRTLKVTFQKESRSVYQLQY
|   ||||| || .|. |||..||| |   |.|   .  |       ||.  .    . | ...|      .       .. | ..|    .| . . |.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MSWPDRGVPSSP---DHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
 || ..  |        ..|  | ... .     |. |||| | | |||. ..|  ||    ..       ||.|  ..|. |   . . ..| |.| 
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 98-286 4.6e-16 53.6 In-house 3-197 (198) alignment 
Range on Protein: 98-286
Range on HMM: 3-197/198.0
SLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQE-PLQTGLFCITL---IKEKWLNEDIMLRTLKVTFQKESRSVYQLQYM
   ||||| || .|| |||..||| |   |.|   .  |       ||.  .    . | ...|      .       .. | ..|    .| . . |. 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDRGVPSSP---DHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDY-VRQLLLTQMipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
|| ..  |        ..|  | ... .     |. |||| | | |||. ..|  ||    ..       ||.|  ..|. |   . . ..| |.| 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt..svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 56-151 4.7e-16 53.4 In-house 48-140 (305) alignment 
Range on Protein: 56-151
Range on HMM: 48-140/305.0
NVRKNRYKDVLPYDQTRVILsllQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEP
.  |||||||   |. || |   .     .||  |..     .  .| || || .|  ||| . ..  |. |.| |  .| | |.|  |.| ....
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 56-147 3.5e-15 50.2 In-house 48-155 (349) alignment 
Range on Protein: 56-147
Range on HMM: 48-155/349.0
NVRKNRYKDVLPYDQTRVILSLL------QEEGH--------SDYINGNFIR--GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRK
   ||||||.|||. .||.|          .. .         |||| |...   ..    ||||| ||| |. ||....   |||..|    . |.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

RCERYWAQ
.|..|| .
kcdiywqe
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 55-295 3e-14 47.1 In-house 50-288 (302) alignment 
Range on Protein: 55-295
Range on HMM: 50-288/302.0
ENVRKNRYKDVLPYDQTRVILSllqeEGHSDYINGNFIRGVDGSLAYIATQGPLPHTL---LDFWRLVWEFGVKVILMACREIENGRkRCERYWAQEQEP
.|..||. .||  .|...|.|.    .   .|.|.  .   . .   | .| |   .     .|||.|..  .. . .. .| |  .   . .. .... 
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-LQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYM--SWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQL
 .. | . .   | .  .|. .  .. |  .  | ||    |.   |..  || .  .. . ...   .. .. |.. .    |.|| |.. |.  . . 
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

LLTQmipPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCST
| ..    .    ..| ..|.|||.||.. .|| .|| ...  .   
lqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 180-288 7e-14 45.9 In-house 212-340 (349) alignment 
Range on Protein: 180-288
Range on HMM: 212-340/349.0
F-QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVE----------EARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQllLTQMIPPDFSL-------F
. ...   ..|||.  |.| ..   |  .|  .|              |. .   .| |||||||||||||.|.|.. .  . .. . ..         .
lavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls..ileplqnesnkiklqallk

DV----VLKMRKQRPAAVQTEEQYRFLYHTV
|.    | ..|||| . ||   |. ..|...
Dlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 218-288 9.6e-13 42.6 In-house 224-291 (297) alignment 
Range on Protein: 218-288
Range on HMM: 224-291/297.0
QGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSlfdVVLKMRKQRPAAVQTEEQYRFLYHTV
.   . .| |||||| ||.||.   | . . |  . ||   .   .. ..|.||.  ||| ||. .||. |
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaa...ilsilreqrarlvqtleqfellydav
subfamily_CG42327_pd Subfamily CG42327 223-294 1.6e-12 41.8 In-house 248-316 (319) alignment 
Range on Protein: 223-294
Range on HMM: 248-316/319.0
EPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDfsLFDVVLKMRKQRPAAVQTEEQYRFLYHTvAQMFCS
 || |||| | ||||.. . |   . | .     |  . ..|  .|..|  ||.| ||| |.|.. ..... 
GPlvvhcsdGvGrtGlviasdiairsleeskrsvd..iPqlvssvrrdrasavltkeqyefiykv.lseyak
subfamily_eak_pd Subfamily eak 47-207 2.6e-12 40.8 In-house 43-201 (332) alignment 
Range on Protein: 47-207
Range on HMM: 43-201/332.0
STVAGSRPENVRKNRYKdVLPYDQTRVILSLLQEEgHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA
|   ..| |.|..| .| ..|||.  | |.  | . .  |||   .   .    || |  .    .  ||..| |     |..   ..|.. .. ..|. 
sisetarleavnrnvvk.ivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

QEQ-EPLQTGLFCITlIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHM
..  | |. | . ..  ||   .. .  | |...   |.  |.  ..  | .  .|   | .
dktreelkfGildve.rkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedfl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 55-127 3e-11 37.4 In-house 36-113 (347) alignment 
Range on Protein: 55-127
Range on HMM: 36-113/347.0
ENVRKNRYKDVLPYDQTRVILSLLQE-EGH----SDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVI
 .. ||| |||   |.|||.||  .   ..      |||   |.  . |  || || |||.|. |||..|    |  .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 47-106 9.6e-11 35.7 In-house 39-95 (95) alignment 
Range on Protein: 47-106
Range on HMM: 39-95/95.0
STVAGSRPENVRKNRYKDVLPYDQTRVILSLlqeEGHSDYINGNFIRGVDGSLAYIATQG
.  .||   |. |||. ...||| |||.|.       |||||  |. |     .|||.||
pytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 99-182 2.8e-09 30.8 In-house 236-315 (440) alignment 
Range on Protein: 99-182
Range on HMM: 236-315/440.0
LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACReIenGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEdIMLRTLKVTFQK
 |.|||| ||  |.||||||| .. .  |.|  . .    | |  ||  .   .  | | .     . .|  . .|||.. ...
nafiatqmpldstvldfwrlvhdyristiimlnq.l..ndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkyke
subfamily_PTPDC1_pd Subfamily PTPDC1 191-285 2.8e-09 31.7 In-house 86-169 (182) alignment 
Range on Protein: 191-285
Range on HMM: 86-169/182.0
QYMSWPDRGVPSsPDHMLAMVEEARRLQGSGpePLCVHCSAGCGRTGVLCTVdyvrQLLLTQMIPPDfslfDVVLKMRKQRPAAVQTEEQYRFLY
  ..|.| ||.|  ...| .|  .      |   . ||| || |||||| ..     |. .. . ..    . . ..|..|| ..|| || ... 
ynfgwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliac....ylvyakrltae....kaiklvrskrpksiqtreqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 189-293 5.8e-09 31.4 In-house 81-178 (194) alignment 
Range on Protein: 189-293
Range on HMM: 81-178/194.0
QLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP-EPLCVHCSAGCGRTGVLCTVDYVRQLlltqmippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHT
.   . .||.|.. | . .|  .. . .     | .   ||| || ||||.|.    .  |        ..|. . .  .|  || |... .... |.  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl........gmsaeeAialfrekRpgaipnqdyleallkr

VAQMFC
. ... 
ykelrk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 55-96 9.5e-09 29.2 In-house 38-78 (244) alignment 
Range on Protein: 55-96
Range on HMM: 38-78/244.0
ENVRKNRYKDVLPYDQTRVILSLLQEEGhSDYINGNFIRGVD
 |. |||| ..||.|.||||||  ..|| ||||| |.|.| .
anatknryinilpfdetrvilssskkeg.sdyinanyiqgsq
subfamily_ptpA1_pd Subfamily ptpA1 257-293 1.2e-07 25.8 In-house 363-399 (418) alignment 
Range on Protein: 257-293
Range on HMM: 363-399/418.0
DFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC
|| || .|||.|.|||  ||  ||| | |.|. .   
dfnlfsivlklreqrpgmvqqleqylfcyktildeiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-96 2.7e-07 24.3 In-house 42-87 (440) alignment 
Range on Protein: 51-96
Range on HMM: 42-87/440.0
GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVD
 | |.|  ||||...| ||..||.|  ..   .|||||  .| |..
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 66-153 1e-06 23.1 In-house 3-76 (130) alignment 
Range on Protein: 66-153
Range on HMM: 3-76/130.0
LPYDQTRVIlsllqeegHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACrEIENGrkrcERYWAqEQEPLQ
|... .|.           .||| .|.  .. .  |. || ||  | .|||... |  | |...    .|.     . ||  . |||.
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywp.dsePle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 56-144 1.4e-06 22.0 In-house 34-120 (332) alignment 
Range on Protein: 56-144
Range on HMM: 34-120/332.0
NVRKNRYKDVLPYDQTRVILSllQEEGHSDYINGNFIRGVDGSLAYIATQGPL-PHTLLDFWRLVWEFGVKVILMAcREIENGRKRCERY
|.  ||   .  .|..|| |.   ..|. |. | ... |     ||| .| |.  ||   |||.| |    .||.   .|.. .||   |
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf.gdidekqkrkapy
subfamily_DSP23_pd Subfamily DSP23 206-286 2.3e-06 22.3 In-house 72-140 (148) alignment 
Range on Protein: 206-286
Range on HMM: 72-140/148.0
HMLAMVEEARRLQgsgpEPLCVHCSAGCGRTGVLCTVDYVRQllltQmippDFSLFDVVLKMRKQRPAAVQTEEQYRFLYH
... .||||   .    | . |||  | |||| . .  .|..    .    ...  . . ..|..|| .|.| || . ...
efvrvveeaeekn....eavsvhcllgrgrtgtmlacylvke....r....klaaaeaiaevrrlrpgsvetveqeklvrd
PTEN_1 190-240 3.5e-06 21.9 In-house 97-148 (196) alignment 
Range on Protein: 190-240
Range on HMM: 97-148/196.0
LQYMSWPDRGVPSsPDHMLAMVEEARRLQGSGPE--PLCVHCSAGCGRTGVLC
   ....| |.||  ..........     | |.     ||| || ||.|...
ylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 227-289 3.5e-06 21.2 In-house 2-61 (69) alignment 
Range on Protein: 227-289
Range on HMM: 2-61/69.0
VHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
||||.| |||| . ..      . .. .     .|. |  ||| ||  |  |..| |.. ...
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_eak_pd Subfamily eak 227-307 4e-06 20.5 In-house 241-316 (332) alignment 
Range on Protein: 227-307
Range on HMM: 241-316/332.0
VHCSAGCGRTGVLCTVDYVRQLLlTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMfcstLQNASPHYQNIK
. .. |  |.||.  .| . .|.  . .   .|. |..||....|  .| .. |. |.|. | .     |..  ......|
iqsarGsaraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy....llrrnnrlrdlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 226-289 4.3e-06 21.0 In-house 2-62 (69) alignment 
Range on Protein: 226-289
Range on HMM: 2-62/69.0
CVHCSAGCGRTGVLCTVDYVRQLLLTQMIppdFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVA
 ||||.| |||| . ..      . .. .     .|. |  ||| ||  |  | .| |.. ...
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalv