Gene PTPN13 in Homo sapiens

Synonym: FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, PTPN13

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN13
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP075_AA protein Get Run
HsapP075_AA_2201-2475 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN13_pd Subfamily PTPN13 2207-2478 2.9e-144 474.3 In-house 1-273 (273) alignment 
Range on Protein: 2207-2478
Range on HMM: 1-273/273.0
IRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQ
|..|.. |||..|..|...|.||||||.| .|..|||..||||.|.||||.|||.|||||||||||.||.||||.|..|||||||||.|| |||||.|||
iaalqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq

KSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR
|..||||.|.|.|..|.||.||||.. .|...|||||...|...|.|.||||||....|....|.|...||||..||||..||....||.|....|....
kaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

-SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
 .|||..|||||||||||||.||||||||..| .||....||..| ||.|.|||.|||||.|..||.||..|.
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksll
0050432 (Phosphotyrosine protein) phosphatases II 2178-2476 9.2e-98 322.6 In-house 3-301 (308) alignment 
Range on Protein: 2178-2476
Range on HMM: 3-301/308.0
FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIP
......| .|....   . ...  ....... | ..|| |. ..| | |...||| .. ... .||. |||||.||||| .|| |... .|||||.....
lildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgy

VGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHL
. | .  .||.|||||.||.|||.|.|||...|| |.|..|| ...|| .|||. ||..... ..... |.....|....|| ..|..... |.|.. |.
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf

NFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
 .|.||||..|..|..||.|. ..|. ...|||. |||||.||.||.|..|..| .. ..  .|. ..|. .| ||.|||||..||.|.|...|. | .
hytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0040438 (Phosphotyrosine protein) phosphatases II 2215-2477 3.4e-86 284.7 In-house 16-279 (317) alignment 
Range on Protein: 2215-2477
Range on HMM: 16-279/317.0
DQGIPSKELENLQELKPLdQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG-----YINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKST
| .....| |.|..||.   . ... .||. ||||..|||||..|| | ..||     |||||....|  | .  .||.||||| ||.|||.|.|||..|
dftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqgvt

VIAMMTQEVEGEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI--HRS
|| |.|...| ...||..|||.   ..|.. ....  |. ...|.|...| ...|| .. |.|.. |. .|.||||..|. ||.|| |....|.   ...
vivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

GPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL
||.. |||||.||.||.|.....| .. .  ..|. . |. .| ||.|.|||..||.|.|...|. |.| 
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0036941 (Phosphotyrosine protein) phosphatases II 2210-2475 1.4e-85 282.5 In-house 6-278 (297) alignment 
Range on Protein: 2210-2475
Range on HMM: 6-278/297.0
LRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-GYINASFIkiPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKS
|..||.  . .|| | |..|..|  . ... .||. |||||.||||| ||| |.||| .|||||..  .. . .. .||.|||||.||.|||.|.|||..
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnv

TVIAMMTQEVEGEKIKCQRYWPNILGKTTMVsNRLRLALVRMQQ--LKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-
||| |.|..|| ...||..|||.  |..  . ..... |.....  |.....| ....|... |.|.. |. .| ||||..|. |..|| || ..|... 
tvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

---RSGPIITHCSAGIGRSGTLICIDVVLGLIS---QDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
   ..||.. |||||.|||||.|..|..| ..        .|| ..|. .| ||.|.|||..||.|.|...|. | 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0051299 (Phosphotyrosine protein) phosphatases II 2217-2474 1.5e-85 282.5 In-house 23-286 (288) alignment 
Range on Protein: 2217-2474
Range on HMM: 23-286/288.0
GIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG-----DEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVI
 .  .| | |..|.|  .. ... .||. ||||..||||| .|| |      ....|||||.|...  | .  .||.|||||.||.|||.|.|||...||
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvrvI

AMMTQEVEGEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDI----QTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI--H
 |.|..|| ...|| .|||.   ..... ....  |.....|....|| ......    .. |.|.. |. .|.||||..|. |..||.|. ..|.   .
vmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
..||.. |||||.||.||.|..|..| .. .   .|. ..|. .| ||.|||||..||.|.|...|. |
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 2226-2476 8.7e-85 279.8 In-house 9-276 (284) alignment 
Range on Protein: 2226-2476
Range on HMM: 9-276/284.0
LQELKPLD--QCLIGQTKENRRKNRYKNILPYDATRVPLG------DEGGYINASFIKIPVG---KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
|. |..    .. ... .||. |||||.||||| .|| |       ....|||||... .     . .  .||.|||||.||.|||.|.|||...|| |.
llsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVml

TQEVEGEKIKCQRYWPNIlgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQ-TREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR----SGP
|..|| ...|| .|||..  ..... ....  |..... ....|| ..|.... | |.|.. |. .|.||||..|..|.|||.|. ..|....    .||
telvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggp

IITHCSAGIGRSGTLICIDVVLGLISQDL---DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
|. |||||.||.||.|..|..| .. ..     .|. ..|. .| ||.|||||..||.|.|...|. | .
ivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 2210-2473 3.7e-84 277.7 In-house 5-271 (273) alignment 
Range on Protein: 2210-2473
Range on HMM: 5-271/273.0
LRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKS
|..||. ..  .| | |..||||  . ... .||. |||||.||||| .|| | ... .|||||... .  | .  .||.||||| ||.|||.|.|||..
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweqnv

TVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--
.|| |.|..|| ...|| .|||.  |..... ....  |..... ....|| ..|....| |.|.. |. .| ||||..|.....||.|| ..|....  
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

--SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
  .||.. |||||.||.||.|..|..| ..     .|. ..|. .| ||.|||||..||.|.|...|. 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 2234-2486 1.7e-83 276.2 In-house 39-293 (564) alignment 
Range on Protein: 2234-2486
Range on HMM: 39-293/564.0
QCLIGQTKENRRKNRYKNILPYDATRVPL----GDEG-GYINASFIKIPVgkEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRY
..   . ..|..||||.||..||..|| |    ||||  |||||||.     ..  ||| ||||..|. |||.|.|||.|..| |.|. .| .| ||..|
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPNIlGktTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSGTLIC
||.  |  |   ..|   |.  ..|. ...| ..|.. ...|.| . . .||.||||. | .. .||..|. .|...   .|||. |||||.||.|| | 
WPek.g..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfiv

IDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQ
||..|  | .. . ||   |...| ||  |||||.||||....||  |.  . | | .. 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl
DSPc_SM00195 2221-2473 3.6e-82 271.0 In-house 4-261 (263) alignment 
Range on Protein: 2221-2473
Range on HMM: 4-261/263.0
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-----GYINASFIKIPvgKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT
.| |.|.| .. ...  .. |.|..||||||||||| ||| | .|       ||||..||..  ...  |||.|||||.|| |||.|.||.|...|.|.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEGEKIKCQRYWPNILgKTTMVSNRLRLALVRMQQLK-GFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIIT
.|.| .|.||.||||.   ..... ..... ||. .. |  ...| ..|.  ...| | . ......||||..|......| ....... ..  ||||. 
eeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
|||||.||.||...||..|  .... ..||...|. .| ||.|||||..||.|.|..||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 2221-2473 3.6e-82 271.0 In-house 4-261 (263) alignment 
Range on Protein: 2221-2473
Range on HMM: 4-261/263.0
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-----GYINASFIKIPvgKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT
.| |.|.| .. ...  .. |.|..||||||||||| ||| | .|       ||||..||..  ...  |||.|||||.|| |||.|.||.|...|.|.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEGEKIKCQRYWPNILgKTTMVSNRLRLALVRMQQLK-GFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIIT
.|.| .|.||.||||.   ..... ..... ||. .. |  ...| ..|.  ...| | . ......||||..|......| ....... ..  ||||. 
eeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
|||||.||.||...||..|  .... ..||...|. .| ||.|||||..||.|.|..||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0039614 (Phosphotyrosine protein) phosphatases II 2190-2475 8.3e-80 263.7 In-house 5-290 (297) alignment 
Range on Protein: 2190-2475
Range on HMM: 5-290/297.0
VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPlDqCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINASFIkiPVGKE-E
 . | .  ... . . ..  |. ... ..  .| |.|..||| | . |.. .||. |||||.||||| .|| | .|.|      |||||..  .. .   
rdallesipiplsvldlllllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydllt

FVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKiKCQRYWPNILGkttmVSNRLRLALVRMQQLKGFVVRAMTLEDiqTREVRHISHLNFTAW
  .||.||||| ||.|||.|.|||..||| |.|..|| .. ||..|||.  |    . ....  |.. ..|.|..|| .....  . |.|.. |. .| |
rkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgw

PDHDTPSQPDDLLTFISYMRHIH----RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
|||..|. ...|| |. ..|...    ..||.. |||||.||.||.|... .| ..    ..|. . |. .| ||.|.|||..||.|.|...|. | 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 2220-2474 1.2e-79 263.5 In-house 30-304 (307) alignment 
Range on Protein: 2220-2474
Range on HMM: 30-304/307.0
SKELENLQELKP--LDQCLIGQTKENRRKNRYKNILPYDATRVPLG------DEGGYINASFIKI------PVGKEEFVYIACQGPLPTTVGDFWQMIWE
 || | |.....  |. . |.. .||. |||||.||||| ||| |       ....|||||....      .. .    .||.||||| || |||.|.||
lkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlwe

QKSTVIAMMTQEVEGEKIKCQRYWPNIlgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDI-QTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI
|..||| |.|..|| ...|| .|||.   ..... ....  |.....|.|..|| ....|  .| |.|.. |. .|.||||..|. ...|| || ..|..
qgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

H----RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLD---FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
.    ..||.. |||||.||.||.|.....| .. ..     .|. . |. .| ||.|.||...||.|.|...|. |
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 2214-2472 1.6e-79 262.5 In-house 17-275 (278) alignment 
Range on Protein: 2214-2472
Range on HMM: 17-275/278.0
LDQGIPSKELENLQELKPlDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-----GYINASFIkiPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKS
 .. . ..| |.|.. |. | . |.. .||. |||||.||||| .|| | ..|     .|||||..  .. .    .||.||||| ||.|||.|.||...
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgv

TVIAMMTQEVEGEKIKCQRYWPnilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI--HR
|.| |.|..|| ...||..|||    ..... ....  |.....|....|| ..... .. |.|.. |. ...||||..|.....|| |. ..|..  ..
ttivmLtelvelgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealeds

SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
.||.. |||||.||.||.|.....| ..   . .|. . |. .| ||.|.|||..||.|.|...|.
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 2220-2478 1.1e-77 256.0 In-house 28-289 (293) alignment 
Range on Protein: 2220-2478
Range on HMM: 28-289/293.0
SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
|.| |.|....   .. . ....|| ||||.||||||..|| |      ..  ||||..|.    . |  .||.|||||.|| |||.|.||.||..| |.
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspre..fiatqGPlpetvddfWrmvwekkssiivml

TQEVEGEKIKCQRYWPNilGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDiqTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH----RSGPI
|| ||. |.||..|||.   .....   ... ||  ..|. .|.| ...|   ..| |.. ...||.||||. |.... ||.|.  .|. .    ...||
tqlvekgkvkCeeYWPa..deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPi

ITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
. |||||.||.||.|..| .|  |...   ||  .|  .| .|  .||||.|||| .|..| .|.. .
vvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPN3_pd Subfamily PTPN3 2209-2473 3.5e-76 250.8 In-house 7-274 (280) alignment 
Range on Protein: 2209-2473
Range on HMM: 7-274/280.0
VLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-GYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWE
 |.  |..|   .. |.|   ||  .. . .  ||  ||||..||||||||| | ..   ||||..... .  ...|  |||.||||..|. |||||.||
llkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvwe

QKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVsnRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH
|||..| |.|. ||  ..|| .|||.   ....   .... . . .. | .|.| ..|.| .|.| |.| .| ..|||||. |....|.|.|.. .|...
qksslivmlttlverGrvkChqyWPetedeleyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr

--RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
  .. |.. ||||||||.| || ... | || .  .. . |.|| || ||  .|||..|| |  . || |
sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0045098 (Phosphotyrosine protein) phosphatases II 2222-2475 9.2e-76 250.1 In-house 12-273 (278) alignment 
Range on Protein: 2222-2475
Range on HMM: 12-273/278.0
ELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPlgdegGYINASFIKIPvgKeeFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE
| |.|  | . .... ..  .|. |||||.||||| .||      .|||||.|...  .  . .||.|||||.|| |||.|.||...||| |.|..||..
efefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDI----QTREVRHISHLNFTAWPDHDTPSQP--DDLLTFISYMRHIH----------
..|| .|||.   . ... ..... |. ...|. ...| ......    .. | |.. ||... ||||..||.|  . .| .. ..|. .          
rekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----RSGPIITHCSAGIGRSGTLICIDVVLGLIsqDLDFDISDLVRCMRLQRHG-MVQTEDQYIFCYQVILYVLT
     ..||.. |||||.||.|||.... .| |.  .  .|. . |. .| ||.| .||...||.|.|...|..| 
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
Y_phosphatase Protein-tyrosine phosphatase 2243-2471 5.5e-75 247.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 2243-2471
Range on HMM: 1-234/235.0
NRRKNRYKNILPYDATRVPL-GDEG--GYINASFIKIPVgKeEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKtTMV
|..|||||.||||| ||| | |.||   ||||...|    . .. .||.||||. |..|||.|.|..|..||.|.|...| .. ||..|||.  .. .. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slt

SNRLRLALV-RMQ-QLKGFVVRAMTLEDIQTR-EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSGTLICIDVVLGLI
 ..... |. . . . |....| ..|.. ... | |....| .|.||||..|..|..|| .|  ... .  .|||.. |||||.||.||....|..|  .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

SQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
... ..|. ..|. .| ||.||||...||||.|..||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2243-2471 5.5e-75 247.2 In-house 1-234 (235) alignment 
Range on Protein: 2243-2471
Range on HMM: 1-234/235.0
NRRKNRYKNILPYDATRVPL-GDEG--GYINASFIKIPVgKeEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKtTMV
|..|||||.||||| ||| | |.||   ||||...|    . .. .||.||||. |..|||.|.|..|..||.|.|...| .. ||..|||.  .. .. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slt

SNRLRLALV-RMQ-QLKGFVVRAMTLEDIQTR-EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSGTLICIDVVLGLI
 ..... |. . . . |....| ..|.. ... | |....| .|.||||..|..|..|| .|  ... .  .|||.. |||||.||.||....|..|  .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

SQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
... ..|. ..|. .| ||.||||...||||.|..||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 2234-2474 7.7e-75 247.0 In-house 2-246 (249) alignment 
Range on Protein: 2234-2474
Range on HMM: 2-246/249.0
QCLIGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRY
.. ... .||. ||||..||||| .|| |..      ..|||||.|. .  | .  .||.||||| ||.|||.|.||...||| |.|..|| ...||..|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH----RSGPIITHCSAGIGRSGTL
||.   ..... ....  |..........|| ..|..... |.|.. |...| ||||..|. ..||| || ..|...    ..||.. |||||.||.||.
wpl...ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

ICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
|... .| ..   |..|. . |. .| ||.|.||...||.|.|...|. |
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 2222-2476 2.4e-74 245.1 In-house 31-299 (306) alignment 
Range on Protein: 2222-2476
Range on HMM: 31-299/306.0
ELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDE--G--GYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT
| |.||  | | | .   |. .||..|||||||||.| ||| | ..      ||||..||  | ...  ||| || |.||| |||.|.|...|.|| |.|
efeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmtt

QEVEGEKIKCQRYWPNILGKTTmvSNRLRLALVRMQQLKGFVVRAMTLED-IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH------RSG
.|||  | || ||||.   |..    ....  |. ..|. ...| ....   . .| |.. ...|..||||..|..|. .| |.. ... .      ..|
kevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
||. |||||||| ||.| ||..| ||..   | |.|| .||. .| || |.||||.|| | |..| . . .
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN12_pd Subfamily PTPN12 2237-2483 1.2e-72 239.3 In-house 34-287 (290) alignment 
Range on Protein: 2237-2483
Range on HMM: 34-287/290.0
IGQTKENRRKNRYKNILPYDATRVPLG-----DEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN
 |...||..|||||.||||| .|| |      .. .||||.||| . || |  ||| |||||.|. |||.||||.. ... |. .||| .|.||.||||.
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkle..yiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

ILGKtTMVSNRLRLALVRMQQLK-GFVVRAMTLEDIqtREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIITHCSAGIGRSGTLICID
  .. ..  . ... | . .... .|..|....|    .| |..  ...||||||..||....|| .|. .|....  . |.. |||||.|| ||.| ||
egee.elefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

VVLGLISQDLD---FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT-RLQAEEEQ
 |  |. ..     .|. |||. .| ||. .|||..|| . |. .. ... .|.. ||.
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieek
0042113 (Phosphotyrosine protein) phosphatases II 2238-2474 1.1e-71 236.4 In-house 4-243 (245) alignment 
Range on Protein: 2238-2474
Range on HMM: 4-243/245.0
GQTKENRRKNRYKNILPYDATRVPLGDEGG-----YINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNi
.. .||. ||||..||||| ||| | ..||     |||||... .  ..   .||.||||| ||.|||.|.||...|.| |.|.|.| ...||..|||. 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

lgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR---SGPIITHCSAGIGRSGTLICIDV
  ..... ....  |.....|....|| ........ |.|.. |. .. ||||..|. ...|| |....|.. .   .||.. |||||.||.||.|... 
..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
.| ..   |.... . |. .| ||.|.|||..||.|.|...|. |
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2220-2474 2.5e-71 235.1 In-house 24-279 (288) alignment 
Range on Protein: 2220-2474
Range on HMM: 24-279/288.0
SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
|.| ..| .|.  ..  .|.  .| .||||.|||||| .|| | .     .  |||||.|.  . |.. .||| ||||. ||.|||....|.|.. |.|.
seeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyid..gekkkkkyiatqgPladtvndfWelvyenktstivml

TQEVEGEKIKCQRYWPNilGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEdiQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIIT
|. |||.| ||..|||.  ...      . . ||  ..|. ||.| . ||  .. . ..| .....|||||. | .  .|| ... .   .   .|||| 
telveggktkCeeYWPd..adkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
|||||.||.|| | .| ..  . ..   |. . |  .| ||  .|||. ||.|.|.|.| . 
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0037934 (Phosphotyrosine protein) phosphatases II 2235-2472 4e-71 234.7 In-house 2-240 (243) alignment 
Range on Protein: 2235-2472
Range on HMM: 2-240/243.0
CLIGQTKENRRKNRYKNILPYDATRVPLGDeGGYINASFIKIPvGKeefvYIACQGPLPTTVGD----FWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWP
. |.. .||. ||||..||||| .|| |.. ..||||..|... ..    .||.||||| || |    ||.|.||...||| |.|..|| ...|| .|||
fsiallpenlsknrysdilpydhsrvkleg.sdyinanliyvt.pr....liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

nilGKTtmVSNRLRLALVRMQQLKGFVVRAMTLEDIQ-TREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR----------HIHRSGPIITHCSAGIG
   |..  . ....  |. ...|....|| ..|| .. . ..|.. |. ...||||..|. |.||| |....|          .....||.. |||||.|
...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RSGTLICIDVVLGLIsqdlDFDISDLVRCMRLQRHG-MVQTEDQYIFCYQVILY
|.||||.....| |.    ..|. . |. .| ||.| .|||..||.|.|...|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2221-2481 9.4e-71 233.4 In-house 24-287 (318) alignment 
Range on Protein: 2221-2481
Range on HMM: 24-287/318.0
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDE-----GGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT
.| |.|.  .     |   .. |..|||| |||.|| ||| | .        ||||..|     ...  |||.|.||| |. |||.|.|||.|.|| |.|
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid..GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

QEVEGEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH---RSGPIIT
||.|  |.|..||||.   | ..  ..|.  |    .|. .|.| ....  .. |.|..   ..|.|||...|... .|| ..   ....     |||. 
qeeergkakvhryWPs...kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEE
|||||.|| |. | .|..|  | ..   |. . |. .| ||  ||||||||.|.|.|.|  |.  ..| 
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2232-2476 6.8e-68 223.8 In-house 30-278 (281) alignment 
Range on Protein: 2232-2476
Range on HMM: 30-278/281.0
LDQCLIGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQ
 .     ...||. ||||.||  |||||| .       .  ||||.|..   |..|  |||.|||.|... .||||.|||| ..|.|.|.|.|..|.|| 
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkCh

RYWPNILGktTMVSNRLRLALVRMQQLKGFVVRAMTLeDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRS---GPIITHCSAGIGRSGT
||||.     ..    ...  .. .. . .. | ..| . .. | |....|..||||||  |... .|| | . .......    |.. |||||.||.||
rYWPddns..elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

LICIDVVLGLISQD-LDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
 | .| ..  ....  . |....|. .| .|  ||||  || | |...| .| .
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2222-2476 7.8e-68 223.9 In-house 35-292 (298) alignment 
Range on Protein: 2222-2476
Range on HMM: 35-292/298.0
ELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQ
.|.. ..  . ..  .....||..|||| .|...| .|| | .     |. ||||||..   |..   .||.|.||..|| |||.|..|.....| |.|.
rlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltn

EVEGEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI-HRSG--PIITH
 .| .|.|...|||.   . .   ..... | . ..   ..|| ..... .... |.. .|.|| |||...|..   .|.... .|   ...|  |.| .
leeldktkyhkywPd...egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivq

CSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
||||.||||| | || ||  . ..   |. . |. .| .| |.||||.||.|.|...| .|. 
CsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2220-2481 1.3e-67 223.2 In-house 26-290 (319) alignment 
Range on Protein: 2220-2481
Range on HMM: 26-290/319.0
SKELENLQELKPLdQCLIGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIpvGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
 || ..|.| ..  .    ...||..||||.|||.|| ||| | .     .  |||||||     .|.  .|| |.|| .|. |||.|.||..| .. |.
ekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg..yqerekfiatqaPlentiedfWrmvWeeessivvml

TQEVEGEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLeDIQTREV--RHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR---SGP
|. ||  |.|...|||.   .. ..  || . |   ..|.....| ..| .... ||  |...|  .|.||||| | .   || ..  .|. ..   |||
tklveklkvklkkywpe...enfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

IITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEE
|. |||||.|| || | .|..|  ....   |.   |. .|.||  |||...||.|.|...| ...  ..| 
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdtei
subfamily_PTPN1_pd Subfamily PTPN1 2238-2474 5.7e-65 213.9 In-house 27-271 (290) alignment 
Range on Protein: 2238-2474
Range on HMM: 27-271/290.0
GQTKENRRKNRYKNILPYDATRVPLGD-EGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT
 ...||| .|||... ||| .|. | . .  |||||.....  | .  ||  ||||| ||. ||||.|||||  . |. . || |.|||..|||.   . 
aklpenrnlnryrdvspydhsrikleradndyinaslveleeakrs..yiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

TMVSN--RLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI----HRSGPIITHCSAGIGRSGTLICIDVV
... .  .|.. |.. .. . ..|| . ||...|.| |.|.|  .|.|||   |. |  .| |.  .|.     .  || . |||||||||||.. .| .
ellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtc

LGLISQDLD---FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
| || .  |    ||.. .  .| .|.|..|| ||  | |. ||   
lvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_PTPN14_pd Subfamily PTPN14 2207-2475 5.1e-64 211.1 In-house 13-297 (300) alignment 
Range on Protein: 2207-2475
Range on HMM: 13-297/300.0
IRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG----DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQM
...|   |..|   .| |.... .   ..  .. .|| .|||.|..|||. .|| |     .. |||||| ||..|| .|  ||..||||..|| |||||
akilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqm

IWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT-TMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYM
.|||. ..|.|.|.| |. | |. .|.|.   |  |.  .. ..     .. . .. ....|. . ..| | . || .| ||||. |. ... | ..  .
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

RHI----HR-------SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
. .    ..       . |.. |||||.||.| ||  |...  . .. . ||   .. .| ||  .|||  || | |.|..  | 
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN23_pd Subfamily PTPN23 2222-2474 8.4e-64 210.1 In-house 23-280 (288) alignment 
Range on Protein: 2222-2474
Range on HMM: 23-280/288.0
ELENLQELKpLDQCLIGQTKENRRKNRYKNILPYDATRVPL-GDEGGYINASFIKIpVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEG
|||. |. .   .  |   | .  |||...||||| .|| | | .  ||||||.|  .      .|| |.||..|..|||.|..|||| || |.... | 
eleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkd.lspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeel

EKIKCQRYWPNILGKTTMVSNrLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR------SGPIITHC
.| |..||||.  |.|.   . |...| . .... .| | ..||  ....|...|||..|.||..  |. |..|| |.  ... ..        |.. ||
gkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

SAGIGRSGTLICID-VVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
|||.||.|.. ..  .|  |  ..   || ..|. .| ||. |||...|. |.|...|   
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN9_pd Subfamily PTPN9 2211-2472 6e-62 204.3 In-house 11-288 (297) alignment 
Range on Protein: 2211-2472
Range on HMM: 11-288/297.0
RGLLDQGIpSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWE
.    .|. ||| ..... ..  . |  ... | .||||...| || ||| |       .  ||||.|.     |..  .|| ||||. || |||.|.||
kekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd..GykqkkafiatqGplkktvsdfWrmvWe

QKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMvSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI-
|.  || |.|. ||  ..||..|||.  ....     |... | ... . ..|| .......|.| |...|  |..|||. .||.  .|| ... .|.  
qevlvivmttrvvergrlkcgqyWpleeessae.fgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

-------------HR-SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
             |    ||. ||||||||.||.| .|. |  . .    |. . |. .| ||  ..||..|| |||. .| 
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPRA_pd Subfamily PTPRA 2234-2472 6.1e-62 204.4 In-house 49-293 (330) alignment 
Range on Protein: 2234-2472
Range on HMM: 49-293/330.0
QCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-----GYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRY
 . . . .||..|||. |||||| .|| |          |||||||.    |..  .||.|||.  || |||.|||||||. | |.|.  | .. ||..|
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdk..fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPNiLGKTTmvSNRLRLALVRMQQLKGFVVRAMTLE----DIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSG
||.  |  |     .|...  .. |. . || . ..      . ...| .. . ||.|||   |..|  .| ..  .....   .|||. |||||.||.|
wPd.eGlvt..yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

TLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
|.| .| ||  .  .   |. . |. .||||  ||||. || |.|.|.| 
tfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2243-2476 1.1e-60 200.1 In-house 28-270 (274) alignment 
Range on Protein: 2243-2476
Range on HMM: 28-270/274.0
NRRKNRYKNILPYDATRVPL------GDEGGYINASFIKIPVGKeEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGK-
. .|||||.||| . .|| |       ..  |||| .|| . .. . .|.| |||||.|| |||.||......|| |.|.  | .. ||..|.|.  .  
sqtknryktilPnensrvllesessededssyinanyikGydee.skayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

TTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTreVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR-----HIHRSGPIITHCSAGIGRSGTLICIDVV
 .   . . .  . . . ... || ..|.  .    |.. |  .|.||||..| ... || ..  ..     . .. .|.. |||||||| |  | |.. 
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
.  . ..   |.  .|  .||.| |||||..|| . ....   | |
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRG_pd Subfamily PTPRG 2234-2478 2.5e-60 199.3 In-house 38-291 (563) alignment 
Range on Protein: 2234-2478
Range on HMM: 38-291/563.0
QCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQR
..   | .||.||||| ||..|| .|| | .  |      ||||..|.    ...  .|| ||||..|. |||.|||||....| |.|. || .. ||..
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdv

YWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLED-----IQT-REVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRS--GPIITHCSAGIG
|||.    ...  . |.. |.. ..|    || .....      .   ..... . ..| ||||..|...   |.|.      ...  |||. |||||.|
YWPk...desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvg

RSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
|.||.| .| .|  | |.   .. .... .|.||  .||||.|||| ....| ...  .
rtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2225-2473 2.8e-60 199.0 In-house 30-282 (305) alignment 
Range on Protein: 2225-2473
Range on HMM: 30-282/305.0
NLQELkpLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD---E--GGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVE
.|.|.   ... .|....|..|||.|.| ..|  |. |     .    |||||...   .|..  ||. ||||..|| |||..|.| | ..| |.|. ||
slyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkk..yivaqgPlkntvadfWrliveekvstivmltklve

GEKIKCQRYWPNILGKTTMVsNRLRLALVRMQQLKGFVVRAMTLED-IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCS
|.| ||..|||.  ....   ... . |   .. .... | ...    . .| | ......| ||||  | ..  ||..|  ... ....   |.. |||
ggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCs

AGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
||.||.|. |..|. |  . ..   |. .... .| .| .|||| ||| |.....   
agvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2237-2476 1.6e-59 196.1 In-house 14-266 (270) alignment 
Range on Protein: 2237-2476
Range on HMM: 14-266/270.0
IGQTKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPVGKEEFvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN
. ..  ... |||..|||  |||| | .     .  |||| ...   |...  ||| .||||||. .||.||||.|.| |.|.|. .|  . ||.||||.
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

ILGK-TTMVSNRLRLALVRMQQLKGFVVRAMTLEdiQTREVRHISHLNFTAWPDHDTPSQPD------DLLTFISYMRHI----HRSGPIITHCSAGIGR
  .. ...    .. . .  .. .|.... ..||  .. | |.. |  ...||||  |...|      .||. .  .|.     ....|...|||||.||
epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

SGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
.|||| .| .. |....   |.  ... .| .|  .||. .|| | |....    |
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRK_pd Subfamily PTPRK 2239-2472 1.7e-59 196.2 In-house 39-275 (314) alignment 
Range on Protein: 2239-2472
Range on HMM: 39-275/314.0
QTKENRRKNRYKNILPYDATRVPL----GD-EGGYINASFIkiPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNil
. .|||.|||...||.|| .|| |    || .  ||||..|     |    .|. ||||. || |||......... | |.|. ||  ..|| .|||.  
kkdenreknrsgdilaydrsrvflitidgdpssdyinaali..dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe..

gkTTMVSNRLRLALVRMQQLKGFVVRAMTLED--IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI--HRSGPIITHCSAGIGRSGTLICIDV
   |.| . ... ||... |. .||| ...|    .  |.| . ...|..|||||.| .   ||...  . .   .. |.|. ||||| ||.|| | ||.
..dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
|| .| ..   |.   |. .| ..  ||.||.||.|.|.||| 
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Ptp69D_pd Subfamily Ptp69D 2220-2473 2.7e-59 195.8 In-house 25-285 (307) alignment 
Range on Protein: 2220-2473
Range on HMM: 25-285/307.0
SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG-----DEGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
 || |.|.. .   .. ... |||  ||||..| ..| ||| |      ..  ||||||||    ||.. .|| |.|. .|.||||.||.||..|.| |.
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik..gykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TQEVEGEKIKCQRYWPNIlgkTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQ-----TREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--S
... | .. ||..|||.    ...  . .   ||. .. . .. |.. .  ..       . |..   ..|.|.|   | ..  || .|. .|....   
snlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnr

GPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
.||. ||||| ||||.....|..|  . ..   || . |. .| ||  .||  .||.|.|. .|  
sPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2221-2474 7.7e-59 194.1 In-house 23-277 (315) alignment 
Range on Protein: 2221-2474
Range on HMM: 23-277/315.0
KELENLQELKpLDQCLIGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT
.|. .| . .   .  ......| .|||||||||.| .|| |       .  |||||.||    ...  ||| ||||...| |||.|....| | |.|.|
eefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik..svdddkayiasqgPlkasvddfwrmvlqekvttivmvt

QEVEGEKIKCQRYWPNILGKTTMVSNrLRLALVRMQQLKGFVVRAMTLEdiQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRH--IHRSGPIITH
.  ||.||||..|||.  ....   . ....|. ...  . |.| ...   .. | | ..  .|| |||. .. |   || .|  ..    ..  ... |
kkqegdkikcrqywPdrkadsvefGs.ikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
||||.||.| .| || |.  | .    |. ..|. .| .|  .||||..| | |...|  |
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2237-2474 1.3e-58 193.4 In-house 37-276 (515) alignment 
Range on Protein: 2237-2474
Range on HMM: 37-276/515.0
IGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN
. | . | .||||||||||| .|| |       .  |.|||.|.    . .  ||| |||....| |||....... | |||.|.  ||.|||| .|||.
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip..sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

ILGKTTMVSNrLRLALVRMQQLKGFVVRAMTLedIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSGTLICIDV
. |..    . ... || ..   | . | .|.  ..  ..| .   .|| |||. .| .   || .|  ..  |   . |.| |||||.|| | .| || 
kpgdsvkfGs.ikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
|.  . .    |. ..|. .| .|  .|||..|| | |...|  |
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2238-2476 1.5e-56 186.4 In-house 4-244 (250) alignment 
Range on Protein: 2238-2476
Range on HMM: 4-244/250.0
GQTKENRRKNRYKNILPYDATRVPLGDE-----GGYINASFIKIPVGKeeFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIkCQRYWPNi
..  .|. |||| .|...| .|| |  |       ||||||..   ..    .|| ||||..|. |||.|..|.||..| |.|. .| ||  ...|||  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

lgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRS---GPIITHCSAGIGRSGTLICIDV
  ...     ... |   ..   ...| . |   .  . |.. .|.|..|||   | .    | ... ..  ..    .|.| .||||.||||. | || 
..ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
||  . ..   |. .... .| .| ..|....||.|.|..||  |. 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2239-2475 3.2e-55 182.4 In-house 43-285 (297) alignment 
Range on Protein: 2239-2475
Range on HMM: 43-285/297.0
QTKE-NR---RKNRYKNILPYDATRVPLG---DE--GGYINASFIKipVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKiKCQRYW
||.  ..    |.|||||||||  || |    |.    |.||||.|  . |.   .|. | | ..|| |||.|..... ..|.|.... |..| ||.|||
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk..gnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPS--QPDDLLTFISYMRHIHR---SGPIITHCSAGIGRSGTL
..   |...    . . |  ... .||. | ....  ...  | .   .|. |||.. .   .   || .|| .|. .    .||.. ||.||.|| | |
sd...kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl

ICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
. || |.  . .. . || .||. .| .|  .|||..|| | |...| .| 
ltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2241-2471 1.3e-54 180.7 In-house 59-288 (319) alignment 
Range on Protein: 2241-2471
Range on HMM: 59-288/319.0
KENRRKNRYKNILPYDATRVPL----GDEG-GYINASFIKIPVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTqevegeKIKCQRYWPNilgK
..|. |||. |||..| ..| |    | |.  ||||||..    |.   |||.||||. |. |||.||||.... | ..|      | || .|||.   |
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl...k

TTMVSNRLRLALVRMQQLKGFVVRAMTLED-IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR----SGPIITHCSAGIGRSGTLICIDVV
. .  .|  . .  ... . .||| . | .  . ...|.|    |  |||.  | .| ||....  .||...      .|. |||||.||.|. | .||.
ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
|  . ..   |. ..|| .| ||  .||   || |.|  .|
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2241-2471 4e-54 179.0 In-house 23-252 (284) alignment 
Range on Protein: 2241-2471
Range on HMM: 23-252/284.0
KENRRKNRYKNILPYDATRVPL----GDEG-GYINASFIKIPVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTqevegeKIKCQRYWPNilgK
..|. |||. .||..| ..| |    | |.  |||||||.    |.   |||.||||. |. |||.||||.... | ..|      | || .|||.   |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl...k

TTMVSNRLRLALVRMQQLKGFVVRAMTLED-IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR----SGPIITHCSAGIGRSGTLICIDVV
. .  .| .. .  ... . .||| . | .  . ...|.|    |  |||.  | .| ||....  .||...      .|. |||||.||.|. |..||.
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

LGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
|  . ..   |. ..|| .| ||  .||   || |.|  .|
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2224-2478 5e-54 178.1 In-house 27-287 (290) alignment 
Range on Protein: 2224-2478
Range on HMM: 27-287/290.0
ENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG------D-EGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQ
. |.  .   .  .| |..|...||..||..||  |..|       | .  ||||..||    ||.  ||| |||.. |. |||..||..|.|.| |.|.
kmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn

EVEGEKIKCQRYWPNIlgKTTMvSNRLRLALVRMQQLKGFVVRAMTLEDIQT-REVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR---SGPIIT
..| .| ||| |||.   .|..  .  .. |.  ..|.... | . ... ..  . ... ....|.|....   .|   |. |. | ...|    ..|. 
iieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivv

HCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
|||...|||.... ... .    ..   |. .... .| |. |.|||..|| . .|..|  |....
HCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2235-2478 8e-52 171.0 In-house 39-282 (287) alignment 
Range on Protein: 2235-2478
Range on HMM: 39-282/287.0
CLIGQTKENRRKNRYKNILPYDATRVPLGDE-GGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNil
  .. ...|. |||...||..|  ||.| .|   ||||.||.    ||.  .|....|.  |. .||..|.... |.| |..|| | .. .| .|||.  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid..gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe..

GKTtMVSNRLRLALVRMQQLKGFVVRAMTLEDIQ-TREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR---SGPIITHCSAGIGRSGTLICIDV
.|. .|    ...|.  .. .|...| . ..  . . . ...   ..|.|...   ..|   |  |  | . .|    ..|. |||...|||.... ...
eks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
 .    ..   |. .... .| |. |.||| .||.| ....|  |.  .
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2242-2471 3e-51 168.9 In-house 2-236 (237) alignment 
Range on Protein: 2242-2471
Range on HMM: 2-236/237.0
ENRRKNRYKNILPYDATRVPLGD---EGGYINASFIKIPVGKEEfVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTm
||. |||| ||  || .|| |     .  ||||...|   |     |||.|||| ..  |||||.|..| .|| |.|  .||...|| .|||.    .. 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpk.kyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa.

vSNRLRLALVRMQQLKGFVVRAMTLE-DIQTREVRHISHLNFTAWPDHDTPSQPDDLLTF----ISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGL
    | ..| . ...  . ||...|   .. .||| |   .||.|||.  | |   || |    |   .|. .||| | |||||.||.| .. || .|  
.ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
  .    || . | ..  .|  ..||.|||.| .|.||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2229-2472 8.7e-51 167.7 In-house 38-277 (315) alignment 
Range on Protein: 2229-2472
Range on HMM: 38-277/315.0
LKPLDqclIGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKIPvgKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI
|.|||   . .  ||..|||| ||..|| .|| |      ..  |.||.||.    . .  |||.|||....|.|||....|.. . | |.|. ||||| 
lhpld...vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekr

KCQRYWPNIlgktTMVSNRLRLALVRMQQLKGFVVRAMtlEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRS
|...|||.      ..  .. ....  .. . . ||..    .   ..|..  |..|.||| . |     |. .|  ..  |    |.|. |||||.||.
kaekywpdk....kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrt

GTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
||.|..| ||  .  .   |. .... .| .| .|||. .|| | |...| 
Gtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPRN_pd Subfamily PTPRN 2233-2470 1.9e-50 166.3 In-house 45-288 (297) alignment 
Range on Protein: 2233-2470
Range on HMM: 45-288/297.0
DQ-CLIGQTKENRRKNRYKNILPYDATRVPLGDE-----GGYINASFIKiPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQ
.. . ......| .|||.|..|||| .|| | .|       |||||.|       . .|||.||||..|| |||||.||| ..|| ..|.  | .  .|.
pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

RYWPNIlGKTTMVSnrLRLALVRMQ-QLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH--RSGPIITHCSAGIGRSGT
||||.  |. .       . ||      . ..||.. | ..||.| | .. . | .||....|...  || |   .   .  || ||. |||.| ||.|.
rywpde.Gsevyhi..yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGv

LICIDVVLGLISQDL-DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
 | ||.||  . . . . ||.  .  .| ||.|.|.|.||. |.....
yilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2240-2470 3.2e-49 162.8 In-house 45-284 (325) alignment 
Range on Protein: 2240-2470
Range on HMM: 45-284/325.0
TKENRRKNRYKNILPYDATRVPL---GDEG--GYINASFIKIPVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIaMMTQEVEGEKIKCQRYWPNILG
  ||. |||.||....| .|| |   .|..   |||||...  ..|.  |..|.| ||..|..|.|... . ...|. ... |....| .|  |||. .|
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd..vflaaqaPltatindlWrlvldWrcsvv.vvlneldlgkdrcavywpkemg

KTTMVSnRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--------SGPIITHCSAGIGRSGTLIC
|.      |.. |. ....  .| | . . ...  | | .  ... .|.|  .. .|  |....  . ...         |.||. |||||.||.|..|.
ksktfG.glevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
.  .|  . ..   || . |. .| .|  ||.| ||||..|. .
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2242-2475 4.6e-48 158.5 In-house 37-279 (287) alignment 
Range on Protein: 2242-2475
Range on HMM: 37-279/287.0
ENRRKNRYKNILPYDATRVPLGDEG----GYINASFIkiPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNIlGKTT
 . .|||| ..||.| ||| |  ||     |||| ..  .  ...  .||.|||...||.|||....|..|.....||.|||  . || .|||.   .  
aavkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

MVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYM-------RHIHRSGPIITHCSAGIGRSGTLICIDVV
.|      .| . ..   . |||. | |..||| | .  |.. .|||.  .     |. |.  .       |     ||.. |...||||||.|. . |.
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL-YVLT
.    .    |..  |  .| .| ..||.  |. . |. .  |  |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0041856 (Phosphotyrosine protein) phosphatases II 2243-2474 1.2e-47 157.2 In-house 1-171 (182) alignment 
Range on Protein: 2243-2474
Range on HMM: 1-171/182.0
NRRKNRYKNILPYDATRvplgdEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTqevegekikCQRYWPnilgkttmvsnr
|. ||||..||||| .|        ||||...  .    .  .||.||||. || ||..|..|.. |.| ..|         . .|||            
nldknrysdilpydhsr.....dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp............

lrlalvrmqqlkgfvvramtlediqTREVRHISHLNFTAWPDHDTPSqPDDLLTFISYMRHihRSGPIITHCSAGIGRSGTLICIDVVLGLisqdlDFDI
                         ... |.. .. .. ||||..|. .|.|| ||  ...  ..||.. |||||.||.|||....... |     ....
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

SDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL
 . |. .| .|.|||.|..||.|.....|..|
eeavklvrsrRpgmvitpnqyfflqlallell
0051429 (Phosphotyrosine protein) phosphatases II 2266-2478 3.7e-47 156.5 In-house 4-229 (272) alignment 
Range on Protein: 2266-2478
Range on HMM: 4-229/272.0
GGYINASFIKIPvgkeeF------VYIACQGPLPTTVGDFWQMiWEQKSTVIAMMTQEVEGEKIKCQRYWPNI---------LGKTTMVSNRLRLALVRM
.|||||.... .     .      ......|||| |. |||.. .|.. ..| ....|.| .. || ||||.|          . .|.  ..||. |. .
sgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

QQLKGFVVRAMTLEDI-QTREVRHISHLNFTAWPDHDTPSQPddLLTFISYMRHihrSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFD--------
..|  ...| ..|. . .. |.|.. || .|.|||| .|...  ||........   .||.. |||||..|.||..... .|  .| .  .|        
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

ISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQ
. . |. .| ||.|.||||.||.|.|...| .| .|.
leeaveelraqrpgavqteeqylflyeallellrsll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2233-2471 3.1e-45 149.2 In-house 23-263 (283) alignment 
Range on Protein: 2233-2471
Range on HMM: 23-263/283.0
DQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-GYINASFIKIPV-GKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWP
 .. |  ..||.||||...|.|.|  || |  |   ||||.|| .    |..  ||..|.||  || |||.|....| | | |.|.  |...||| .|||
ldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

NilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDI-QTREVRHISHLNFTAWPDHDTPSQPDDL--LTFISYMRHIHRSGPIITHCSAGIGRSGTLICI
.   . ..    . ..| .    . |... ..|     ...   ..|  .  | . .  .  . |  .  .   .  .. |||. |||.||||....| .
k...rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaa

DVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
 . .  .  .   |.   |. || || ..||| ||| . ....|
sasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2232-2472 5.9e-44 145.0 In-house 34-234 (392) alignment 
Range on Protein: 2232-2472
Range on HMM: 34-234/392.0
LDQCLIGQTKENRRKNRYKNILPYDATRVPL-----GDEGGYINASFIKipVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEkikcq
. .  ..|.. | .|||||||||||..|| |       .  |.|||.|.    . |  |||.||| .... |||.|..... | |||.|.  ||.     
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip..sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

rywpnilgkttmvsnrlrlalvrmqqlkgfvvramtlediQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR--HIHRSGPIITHCSAGIGRSGTL
                                        .  ..| ..   || |||.| | .   || ||  ..  . . . |.| |||||.||.| .
........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvv

ICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
|.|| |.    .    |. ..|  .| .|  ||||..|| | |  .| 
isidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2241-2471 3.5e-42 139.2 In-house 5-237 (239) alignment 
Range on Protein: 2241-2471
Range on HMM: 5-237/239.0
KENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPVGKEEfVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGK
. |. |||| ||. || .|| |          |||||...   |  .  ||| || . .. ||||.|.|...  || |.|  .|| | ||..|||.   |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

TTmvsnRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRH--IHRSGPIITHCSAGIGRSGTLICIDVVLGL
       ||..| . . .  ...|.. . ..   | |.. .  || |||.  |     .| .   . .  .  . | . |||||.||.|... || .|  
yc....nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
  ..   || . |...| .|  |||| .||.| .  .|
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2241-2471 3.7e-42 139.1 In-house 6-238 (239) alignment 
Range on Protein: 2241-2471
Range on HMM: 6-238/239.0
KENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPVGKEEfVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGK
. |. |||| ||. || .|| |          |||||...   |  .  ||| || . .. ||||.|.|...  || |.|  .|| | ||..|||.   |
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

TTmvsnRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRH--IHRSGPIITHCSAGIGRSGTLICIDVVLGL
       ||..| . . .  ...|.. . ..   | |.. .  || |||.  |     .| .   . .  .  . | . |||||.||.|... || .|  
yc....nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
  ..   || . |...| .|  |||| .||.| .  .|
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
0036282 (Phosphotyrosine protein) phosphatases II 2267-2468 2.1e-41 136.8 In-house 3-164 (174) alignment 
Range on Protein: 2267-2468
Range on HMM: 3-164/174.0
GYINASFIKIPVGKEefVYIACQGPLPttvgdFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNilgkttmvsnrlrlalvrmqqlkgfvvramtledI
 |||||.... .  .   .||.||||.     ||.|..|...|.. |...|.| .. || .|||                                    
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

QTREVRHISHLNFTAWPDHDTPSQPDdLLTFISYMRHI---HRSGPIITHCSAGIGRSGTLICIDVVLGLISqDLDFDISDLVRCMRLQRHGMVQTEDQY
.. ..|.. .. .. |||| .|. .  ||.|.......   ...||.. |||||.||.|||.... .| ..      |. |||| .||||.|||||..||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

IFCYQ
.|.|.
rflyy
0043147 (Phosphotyrosine protein) phosphatases II 2265-2468 5.1e-41 135.6 In-house 4-155 (172) alignment 
Range on Protein: 2265-2468
Range on HMM: 4-155/172.0
EGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEvegekikcqrywpnilgkttmvsnrlrlalvrmqqlkgfvvramtlE
   |||||......   .  .||.||||. |. |||.|..|.. |.| ..|..                                              .
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel..............................................l

DIQTREVRHISHLNFTAWPDHDTPsQPDDLLTFISYMRH---IHRSGPIITHCSAGIGRSGTLICIDVVLglisqdLDFDISDLVRCMRLQRHGMVQTED
 . . ..|.. .. .. ||||..|  .. || |......   . ..||.. |||||.||.|||.... .|      |.... . |. .| .| |.||...
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYIFCYQ
||.|.|.
qyrflyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2241-2471 1.4e-40 133.8 In-house 54-280 (290) alignment 
Range on Protein: 2241-2471
Range on HMM: 54-280/290.0
KENRRKNRYKNILPYDATRVPLG--DEGGYINASFIKipvGKeEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTM
  . .|||||..   | ||| |    .| |. | ..|   |  . ..|  ||.|  || |.|.|. ..| ..| |. . .|  | ||..|.|.  |..  
ntefkknrykdvvcndktrvilkdGydGdyvhanyvk...Gl.kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

VSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIhrSGPIITHCSAGIGRSGTLICIDVVLGLISQDL
  .   |     .. .  . . ... | ..     . ||.  .|||.  .     ||  .  .|..  |||.. ||||||||.||.. |.| | .. .  
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka..sGpvvvhcsaGiGrtGtfvaievglqilldGk

DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
..|. |||| .|  | . || . ||.   ...|
eldlldlvralrnsrlnsvqvdiqylalveill
subfamily_CG7180_pd Subfamily CG7180 2233-2473 1.6e-40 133.6 In-house 32-290 (296) alignment 
Range on Protein: 2233-2473
Range on HMM: 32-290/296.0
DQCLIGQTKENRRKNRYKNILPYDATRVPLGDEG-----GYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKiKCQR
..|  |  |||| |||. ...||| .|| |   .      ||||...   . |.|  ||  ..|   ||..||........  . ..|.. . .| ... 
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPNILgKTTMvsNRLRLALVRMQQLKGFVVRAMTLEDI----------QTREVRHISHLNFTAWPD-HDTPSQPDDLLTFISYMRHI-------HRSGP
||||   |.      . . .|...|.  .. | . |              . |.| . ....| |.  .  |.    |. ..  .| .          ||
ywpnks.keqy..geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

IITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL-YV
.. ..| | .|||  . ||. | |....  .|. . |. .| .| ..|.. ..| ..|.|.| .|
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2220-2472 6.5e-40 131.9 In-house 23-277 (439) alignment 
Range on Protein: 2220-2472
Range on HMM: 23-277/439.0
SKELENLQELKPLDQCLIGQ--TKENRRKNRYKNILPYDATRVPLGD-----EGGYINASFIKIPvgKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIA
....|...  .|  .|       . .. |||||.. ..| ||| | .        |||| .||     .. .|||.|||   |. |||....|.|.. | 
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy..yddklyiatqgpkkettddfwrlviekktvtiv

MMTQEVEGEKikcqrYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTL--EDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTF---ISYMRHIHRS
|.|. ||  |     |||    .. ..   . .   |  .|  .|.| . .  |  .|.  | . .. ..||||.. |.|   .| |   |      .  
mltnlvesyk.....ywps...daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

GPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
||.. |||||.||.||.|..|. |  .  .   ||  .|. .| ||. |||.  ||.| |. .| 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2224-2475 8.6e-40 131.3 In-house 22-294 (301) alignment 
Range on Protein: 2224-2475
Range on HMM: 22-294/301.0
ENLQELKPlDQCLIGQTKENRRKNRYKNILPYDATRVPLGDE-------GGYINASFIKIPVGKEEFvyIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQ
..|.| .. ..| .| ..||.. ||.||| .||  |. |  .         |||||.|.    |..|  || |||.  |. |||..||..| . | |.|.
kelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkf..iaaqgpmkktlvdfWrliwqekpvsivmvtn

EVEGEKIKCQRYWPNILGKTTMVsNRLRLALVRMQQLKGFVVRAMTL--EDIQT-------------REVRHISHLNFTAWPDHDTPSQPDDLLTFISYM
. || | ||..||||   ... .   .   ||  | .  ||.| ...  .|                .. ...  |. | ||..    .|   |  |  .
lkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv

RHIHR---SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
 |  .    ||.. |||....|||. . ... |     .   |. .... .| .. |.|.| .||.. |.||   |.
ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0049260 (Phosphotyrosine protein) phosphatases II 2282-2468 1.9e-39 130.1 In-house 8-144 (152) alignment 
Range on Protein: 2282-2468
Range on HMM: 8-144/152.0
EFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWpnilgkttmvsnrlrlalvrmqqlkgfvvramtlediqtrevrhisHLNFTA
 | .||.|||.| |. |||.|..|.. |.| |.|...|  |.|| .|.                                              .  .. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlp

WPDHDTPSQPDDLLTFISYMRH--IHRSGPIITHCSAGIGRSGTLICIDVVLglisqdLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ
|||| .|. .. || ..  ...  ....||.. |||||.||.|||.... .|      |.... . |. .| .| |.|....|..|.|.
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 2235-2477 5e-39 130.2 In-house 38-283 (314) alignment 
Range on Protein: 2235-2477
Range on HMM: 38-283/314.0
CLIGQTKENRRKNRYKNILPYDaTRVPLG----DEGGYINASFIKIPvgkeeFVYIACQGPLPTTVGDF----------WQMI--WEQKSTVIAM-----
.|...  .|| ||||..|||.| .|| |.    .  .|||||... .       .||.||||. || ||          |.|.  ..... .| |     
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------MTQEVEGEKIKCQRYWPNILgkttmvsnrlrlalvrmqqlkgfvvramtlEDI--QTREVRH-ISHLNFtAWPDHDTPsQPDDL
                 ..  ..  . . ......                               | .  . .  |. | .|..  .||...|  ..|.
ladelsrLdaAlgKtpllildgngneptaadlellk..............................eelydpelferlgikylri.pvpDgsap.lledf

LTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLIsqdlDFDISDLVRCMRLQRH-----GMVQTEDQYIFCYQVILYVLTRL
. |. ...  .. ||.. ||.||.||.||..... .. |     .... . .. .||.|.     |.... .||.|.....|. | .|
deflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0046846 (Phosphotyrosine protein) phosphatases II 2268-2474 5.8e-39 129.0 In-house 14-173 (176) alignment 
Range on Protein: 2268-2474
Range on HMM: 14-173/176.0
YINASFIKIPVgkeefvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTmvsnrlrlalvrmqqlkgfvvramtlediq
||||..|  .       .||.||||| |. ||..|..|.. |.. ..|.||| ...|| .||| . .                                 
yinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

trevrhisHLNFTAWPDHDTPSQpDDLLTFISYMRHIHRSG-PIITHCSAGIGRSGTLICIDvvlgLISQDLDFDISDLVRCMRLQRH-GMVQTEDQYIF
        .  .. ||||..|.  ..||... ..|   ..| |.. ||||||||.|||....    |.  . .... . .. .| ||. |.|||..|| |
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

CYQVILYVL
.|...|..|
lyefellll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2237-2475 1.8e-38 127.3 In-house 35-279 (307) alignment 
Range on Protein: 2237-2475
Range on HMM: 35-279/307.0
IGQTKENRRKNRYKNILPYDATRVPLGDEG---GYINASFIKIPVGKEEFvyIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNIL
.   . |  ||||...   | .|. .  .|    || | .. | .    |  |..|||| .|. .|| |. ..|   . |. . .|  ||||..|||   
veafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkf..icaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GKTTMVSN---RLRLALVRMQQLK--GFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHihRSGPIITHCSAGIGRSGTLICID
|.. . ..    . .| . ...|     ..   ||.   ... | |.||... |||. .|      . ... .|      |.. |||||.|||||...| 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..dtnpvvvhcsaGvGrsGtivais

VVLGLISQDLD-FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY-VLT
.|   . .  .  |. .||. .| |||  .||| ||.. ..|.|   | 
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2235-2471 3.5e-36 119.6 In-house 27-267 (285) alignment 
Range on Protein: 2235-2471
Range on HMM: 27-267/285.0
CLIGQTKENRRKNRYKNILPYDATRVPLGD-EGGYINASFIKIPvGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNIL
|     . |   ||| ..   . ||| | . .  || ||....| ||..  ||. ||||| |. |||.||...| . . |.   .||   ||  |.|. |
ctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmp.gkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

GKTTMVS-NRLRLALVRMQQLKGFVVRAMTLEDI--QTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHCSAGIGRSGTLICIDV
|.   .    . |. .. . . | .. |.|. .    . |  .. |..   |||. .| .   .. .  .....  .  ||  |||||.||. |.. || 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidy

VLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
    | .. . .. |.|| ||  |   ||.  |..| | |..
atirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2221-2472 1.4e-35 117.3 In-house 15-267 (281) alignment 
Range on Protein: 2221-2472
Range on HMM: 15-267/281.0
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG------DEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMM
.|. ||    | | | . .   | .|||| ||   | .|| |       .   || | .|. |. |    ||  |||   |  |||.|||....| | |.
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg..yiltqgpkketradfwrmiwqenttaivml

TQEVEGEKIKCQRYWPNIlGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEdiQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRhiHRSGPIITHC
 | .| .. ||  |.|    .  .  ..| ..       | .|   . |      | | |.|  .  ||| . |   . .|  .  .|   || | . ||
cqfletnrekcaeyfprn.ahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkir..arstppvihc

SAGIGRSGTLICIDVVLGLISQDLDF-DISDLVRCMRLQ-RHGMVQTEDQYIFCYQVILY
|||.||||||..... |  |   . . || ..|  .|.  |   ||| .||.. ..|.| 
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2243-2474 3.7e-34 112.7 In-house 55-290 (305) alignment 
Range on Protein: 2243-2474
Range on HMM: 55-290/305.0
NRRKNRYKNILPYDATRVPLGD--EGGYINASFIKIPVGKEEfVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVS
.  ||||...   | . | | .     || | ..  |.  |   .|..||||  |. .|| |. ..|   | |. . ||  |.|| .|||   |.   . 
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

NRLRLALVR----MQQLKGFVVRA--MTLEDIQTRevrHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHrsGPIITHCSAGIGRSGTLICIDVVLGLI
. . .  |     |..     .    .|    |.     . ||..| |||   |      | ..| .|  .   ||. ||||||||.||...|. .|  |
sgivvenvsgskpmerdaeiqitllnltysgdqkm...svrhlqwtewpdrgvppckltslellsairgsk..vpivvhcsagigrtgtivaieyileki

SQDLDF-DISDLVRCMRLQRHGMVQTEDQYIFCYQVILY-VL
... .   . .||...| ||   .|.. ||.| ..|.|  .|
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2242-2397 4.2e-34 112.7 In-house 32-189 (297) alignment 
Range on Protein: 2242-2397
Range on HMM: 32-189/297.0
ENRRKNRYKNILPYDATRVPLG---DEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTM
   |||||..|| .| ||| |     |  |||| ..  |  .... ||  |||| .|| |||....||   ||.|...  |. . ||  |||.. ..   
sslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk

VSNRLRLALVRMQQLkgF-VVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTF
 .. .   | .. .   |  |    |. |   | |.. | .| .||||  ||. .||  |
agdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2242-2475 7.7e-34 112.0 In-house 42-272 (288) alignment 
Range on Protein: 2242-2475
Range on HMM: 42-272/288.0
ENRRKNRYKNILPYDATRVPLGDEGGYINASFIkIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSN
.|  ..||.|.   |.||| | |.  .  |. . .. .| .   | .| || .|.. .|.|. |.    | |... .|  | | . |.|  ||... .  
anptrdryenlprcditrvklsddpdfyiaanv.vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

RLRLALVRMQQLKGFVVrAMTLEDIQTREVRH-ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRsgPIITHCSAGIGRSGTLICIDVVLGLISQDLDF
      .. ....  |.   .|   .. | .  . .| .  |.|.  | .    | ..  .. ...  ||. |.|||.||.|||| | ..|  .  | . 
lctvvkkkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlililialeslrlddfl

DISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
 |  |.  .| .|   .||| ||.. ....|. | 
girsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2221-2470 2.4e-32 107.0 In-house 10-255 (267) alignment 
Range on Protein: 2221-2470
Range on HMM: 10-255/267.0
KELENLQELKPLDQ-CLIGQTKENRRKNRYKNILPYDATRVPLGD-EGGYINASFIKIPVGKEefVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEV
||.|..... .  . .    ...|. .||. . |||| |||.| . |  |||||...    |.   .|. |.||  |..||...| .|| .|| ..|.  
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvf

EGEkIkcQRYWPNILGKTTMVSNrlrLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPD--DLLTFISYMRHIHRSGPIITHCSA
... |  ...||  .|..    .   |.. .  . .    . .|||     |  |   | .    . .|  .|    |.  ..  .    . |.. .||.
tdn.i..rlfwPPkmgqakkyqd...ltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsd

GIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
|.|||||.. ||  |  . ..   || |..| .| || |.|.| ..||......
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_ptpA1_pd Subfamily ptpA1 2235-2430 3.7e-32 106.6 In-house 39-251 (418) alignment 
Range on Protein: 2235-2430
Range on HMM: 39-251/418.0
CLIGQTKENRRKNRYKNILPYDATRVPLG---D-EG-GYINASFIKIPVGKEefvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW
   |. | |  |||| |||| . ||| |    | ||  |||| .|     |.   .|. ||||| |. |||.|.||..  .| |...| |  .|||.|||
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq...fictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PNILG--------KTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPS--QP-DDLLTFISYM-----RHIHRSGPIITH
|. .|        .   |     . || . |     . .  .      | | |.. ..  ||||. |   ||  .||  |.           |  ||| |
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGIGRSGTLiCIDVV
||||.||.||. |  |.
csagvgrtgtf.ctavi
PTPc_DSPc_SM00012 2374-2472 6.1e-32 105.3 In-house 2-105 (105) alignment 
Range on Protein: 2374-2472
Range on HMM: 2-105/105.0
ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR----SGPIITHCSAGIGRSGTLICIDVVLGLISQD-LDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ
..|. .|.|||| .|...|..|... .... ..    |.|.. |||||.||.||....|..|  ...    .||...|. .| ||.||||||.||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VILY
..|.
alle
0051082 (Phosphotyrosine protein) phosphatases II 2267-2470 1.1e-31 104.8 In-house 4-149 (151) alignment 
Range on Protein: 2267-2470
Range on HMM: 4-149/151.0
GYINASFIKiPVgkeefvYIACQGPLPttvgDFWQMIWEQKSTVIAMMTQEVEGEkiKCQRYWPNILgkttmvsnrlrlalvrmqqlkgfvvramtledi
.|||.|..  .       .....|||.    ||.....|.. ..| ....|.| .  .| .|.|.                                   
dyinfsyvt.gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qtrevRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHiHRSGPIITHCSAGIGRSGTLICIDVVLglISqdldFDISDLVRCMRLQRHGMVQTEDQYIFC
     ... |. .. |||...|  .| .| |...... ...||.. |||||.||.|||.... .|        ... . .. .||.|.|.||...|..|.
.....ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqflfq

YQVI
....
lfal
0044763 (Phosphotyrosine protein) phosphatases II 2255-2472 1.4e-30 101.6 In-house 2-169 (178) alignment 
Range on Protein: 2255-2472
Range on HMM: 2-169/178.0
YDATRVPLGDEGG-----YINASFIKipvgkeEFVYIACQGPlpttvGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGkttmvsnrlrlalvr
.| ||| |    |     |||||.|       ...|.....|      |......|.. |.| ..|.|.|. ..|| .|||   |               
ldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

mqqlkgfvvramtlediqtrevrhISHLNFtAWPDHDTPSQPDDLLTFISYMRHI--HRSGPIITHCSAGIGRSGTLICIDVVLGLisqdlDFDISDLVR
                        | .|..  .|||..|. .. .| |. .....   . ||.. |||||.||||||.... .. |     .... . ..
........................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

CMRLQRHgMVQTEDQYIFCYQVILY
 .| .|  .|....|. ..|.. |.
lvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2239-2476 1.2e-29 98.0 In-house 44-289 (305) alignment 
Range on Protein: 2239-2476
Range on HMM: 44-289/305.0
QTKENRRKNRYKNILPYDATRVPLGDE--GGYINASFIKIPVGKEEFvyIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT
.  ... |||||..   |  || |       || | ..  |   . |  | .| ||  |  ||| | ...|   | |. . .|    ||. |..   ...
keaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrf..ictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TMVSNRLRLALVRMQQLKGFVVRAMTLEDI---------QTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHihRSGPIITHCSAGIGRSGTLICI
   ... .   |...  . .  |. .  ..            ..|...|  .  |||   |.    .| ..   |     |||. ||||||||.|... .
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp..skgpivvhcsagigrtgsvvml

DVVLG-LISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTR
. .|  |.. .   |   ... .| ||   .||..||.| .||||  . .
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2246-2475 2.1e-29 97.2 In-house 46-277 (312) alignment 
Range on Protein: 2246-2475
Range on HMM: 46-277/312.0
KNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEFVyiACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLR
 ||| ||  .|  |  | |||  || | |.||    | ||  ..||||  |.  |||.     || | ...  ||    || .|  .|.|   .   |. 
lnrypniqcwdrgrftlagdenfyihanfvkictkperfv..ctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

LALVRMQQLKGFVV-----RAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRsgPIITHCSAGIGRSGTLICIDVVLGLISQDLD
   .   .. |        | . .    | .  .. | ....||||  |   |  | ..| ... ..  |.|.|||||.||.|||. |. ..  . .   
teycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk..pviahcsagvgrtgtlaliesmiaalrhprk

FDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
 .. |    .| .|   |..  ||... ...| .| 
qnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
FERM_M FERM central domain 673-787 1.7e-28 89.5 Pfam-A 2-126 (126) alignment 
Range on Protein: 673-787
Range on HMM: 2-126/126.0
VSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQ-PEVHGVSYFRMEH-------YLP--ARVMEKLDLSYIKEELPKLHNTYVG
.. .... . ...|.|...|.||||. |..|. ||||.|.||.|.||.. .| .  |....|        .||   |...|.  ....... . |  . |
pnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvag

ASEKETELEFLKVCQRLTEYGVHFH
 |..| .|..|...|.| .|||...
lslaeaklkylqaaqslpdyGvslF
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2244-2475 2.8e-28 93.5 In-house 51-282 (301) alignment 
Range on Protein: 2244-2475
Range on HMM: 51-282/301.0
RRKNRYKNILPYDATRVPLGDEGGYI--NASFIKIPvgKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVsN
. |.||...     | | . ..|  .   | .|. .   .   .|| ||||. |  ||| |.   .   |.|..|.|| .. ||. | |   ...  . .
kdkhryptvPckPstavevivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi.g

RLRLALVRMQQL--KGFVVRAMTLEDIQTR-EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRsgPIITHCSAGIGRSGTLICIDVVLGLISQDL
| .. .. ....  |  . |.. .||   . . | . | ... |.|...|    .|  ..  ... ..  ||. ||||||||| ..|  ...   .  | 
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek..PivvhcsaGiGrsvafigteylareveadp

DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
  .... .. .| .|   |||. |  .     .| | 
tieltealkhlrehrwngvqtnsqlywmtlGtvyrli
0048076 (Phosphotyrosine protein) phosphatases II 2346-2472 4.5e-25 83.4 In-house 18-141 (145) alignment 
Range on Protein: 2346-2472
Range on HMM: 18-141/145.0
ALVRMQQLKGFVVRA-MTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG-PIITHCSAGIGRSGTLICIDVVLGlisqdLDFDIS
. .....|| . ...  .| . .. ..|.. .. .. ||||..|. ...||.|. ........| |.. |||||.||.|||......|      |.... 
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsle

DLVRCMRLQRHGMVQTEDQYIFCYQVILY
. .. .| ||.|.|....|..|.|...|.
ealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 2350-2468 4e-24 80.4 In-house 25-139 (144) alignment 
Range on Protein: 2350-2468
Range on HMM: 25-139/144.0
MQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHCSAGIGRSGTLICIDVVLglisqDLDFDISDLVRC
...|.   |  .| |  .. . |.. .. .. ||||..|. ...||.|. ...... ..||.. |||||.||.|||.......      |.... . .. 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealal

MRLQRHGMVQTEDQYIFCYQ
.| .| |.|....|..|...
vrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2291-2469 7.6e-24 78.7 In-house 99-283 (302) alignment 
Range on Protein: 2291-2469
Range on HMM: 99-283/302.0
PLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILG------KTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQT--REVRHISHLNFTAW
|   |.  .| .| . . .... ... ||.|. ||  |. . .|      . |. .  ..  | ..   |.|.. .. ... ..  .  . .. | |.||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDTPSQPDDLLTFISYMRHIHRSgpIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQV
||| .| ...  |  . .     ..  .. |||||.||.|||. |   . | |..   |. ..|  .|  |.| ||.|.| |.   .
pdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2231-2332 4.9e-23 76.4 In-house 35-153 (350) alignment 
Range on Protein: 2231-2332
Range on HMM: 35-153/350.0
PLDQCLIGQTKENRRKNRYKNILPYDATRVPLG-------------DEGGYINASFIKIP----VGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAM
| .   . .  |   ||||||||||. .|| |                  ||||...|..      . .| ||| |.||| || ||...| . | .|| .
psnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

MTQEVEGEKIKCQRYWPNI
.|..|| .  ||.|||.. 
ltsdvelnlekcyrYWqeg
subfamily_egg_pd Subfamily egg 2240-2475 1.3e-22 74.9 In-house 37-271 (307) alignment 
Range on Protein: 2240-2475
Range on HMM: 37-271/307.0
TKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPV--GKEEF-VYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEkiKCQRYWPNILGKT
...|. | | | .   | .|| |  . |     ||.     ||  .  .| .| ||  || |||.|.....   | |.|  .| |  .|. |||.   ..
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesds

TM-VSNRLRLALVRMQQLKGFVVRAMTLEDIQ-TREVRHISHLNFtawpDHDTPSQPDDLLTFISYMRHIhrSGPIITHCSAGIGRSGTLICIDVVLG-L
 . |   ||.  .....    . |   |  .   .| |.. | .     | .  |.    |  .  .|..  | |.. ..  |. ...||..|.. |  |
lvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnl..skpvvvqdilGvskaatlvaieiallsl

ISQ-DLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT
.      . .   |  .||.|.  |..  .|.| |...|... 
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2241-2473 7.1e-22 72.3 In-house 50-289 (310) alignment 
Range on Protein: 2241-2473
Range on HMM: 50-289/310.0
KENRRKNRYKNILPYDATRVPLG----DEGGYINASFIKIPVGKEEFvyIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT
|..  |||| ...  |..|| |       . || | ..|    .. |  | .||||  |. |||.||.....  | .. . .|  . ||  ||| .    
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstf..icsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

TMVSNRLRLA-----LVRMQQLK-GFVVRAMTLeDIQTREVRH--ISHLNFTAWPDHDTPSQpdDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICID
|    |.           . .|   ||   . . | |  ....  .| ...  |||   | .     |    .    | || . |||||..| .... ..
tygcirvtnlsesseefeicnlavtfvpdnvpv.deqpanlkelrvslikwpnwpdrgvpde..kchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalk

VVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV
. .  . . |  |. ...  .. .|   .||| ||..  .| .  
lkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_CG42327_pd Subfamily CG42327 2244-2398 2e-21 71.0 In-house 29-187 (319) alignment 
Range on Protein: 2244-2398
Range on HMM: 29-187/319.0
RRKNRYKNILPYDATRVPL-----GDEGGYINASFIKIPVGkEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGK-TT
. |.|. |..|   ||| |      |.  |..||... .    .  |||.| .|  .  |||...|||.| ||  .|.  |    .| .|.|   .   |
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd.apnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

MVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFtAWPDHDTPSQPDDLLTFI
 .   ....|   .  . ... .. |  ..  | |...|  .  |.. . |...  |.. .
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
FERM_N FERM N-terminal domain 582-670 2.4e-21 65.8 Pfam-A 1-80 (80) alignment 
Range on Protein: 582-670
Range on HMM: 1-80/80.0
IMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALAT--LKDNEYFFVDPDLKLTKVAPEgwkeepkkktkATVNFTLFFRIKFFM
..||.|. .|.|.| ..........|....|| |.. | ||.   |.||....|.| .|.. ..|           .. ..||..|.||..
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgve...........egkpttlllrvkfyv
FERM_C FERM C-terminal PH-like domain 794-881 3.6e-21 65.5 Pfam-A 2-89 (90) alignment 
Range on Protein: 794-881
Range on HMM: 2-89/90.0
KSQTGILLGVCSKGVLVFEVHNGVRtlVLRFPWRETKKISFSKKKITLQN--TSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ
|..| .||||..||.|..| .. .     .|||.| .|.||..||.|..   ...  .. |..........||.||. .|.. ...| ..
kkgtdllLGvdakGlliyeknskls..nksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrrrrkvd
PDZ PDZ domain (Also known as DHR or GLGF) 1375-1455 3.6e-21 65.3 Pfam-A 2-80 (81) alignment 
Range on Protein: 1375-1455
Range on HMM: 2-80/81.0
VELAK-NDNSLGISVTGGVNTSvrHGGIYVKAVIPQGAAESDGrIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL
|.| | . ..||.|. || . .    ||.|. | | |||| || ...||..|.||||..|. .| .||. .......|.|..
vslekekrgglGfslkggsdkr..dkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
PDZ PDZ domain (Also known as DHR or GLGF) 1100-1181 2.1e-20 62.8 Pfam-A 2-80 (81) alignment 
Range on Protein: 1100-1181
Range on HMM: 2-80/81.0
VNLKKDAKYGLGFQIIGGEKMGrlDLGIFISSVAPGGPADLDGcLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI
|.|.|.   ||||.. ||.. .  | |||.|.| |||.|. || ||.||...||| |..|.|||  |....... . |||.|
vslekekrgglGfslkggsdkr..dkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2243-2482 2.6e-20 67.7 In-house 19-270 (290) alignment 
Range on Protein: 2243-2482
Range on HMM: 19-270/290.0
NRRKNRYKNILpYDATRVPLGDEG-----GYINASFIKIPVGKEefvYIACQGPLP-------TTVGDFWQMIWEQKSTVIAMMTQEVEGEKI----KCQ
.  ..|... |   ||||.| . |     .|| |.....| | .    |. | |.         |. .|| |. . |.. . |. .  | ..      |.
hemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglr...liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

RYWPNILGKTTMVsNRLRLALVRMQQLKGFVVRAMTLEdIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRhiHRSGPIITHCSAGIGRSGTLIC
.| |.  |.   . . | .    . . ... .| ....  . .|   . |  .  | .  .. ..  ||. |....   .  |.| ||  || || .|  
kYvpesvgeelkf.kgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaa

IDVVLGLIS-QDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAE---EE
|..   .|  .  .. . |..  .| ||  ..... .. |   .|.  ... . .   ||
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2215-2487 3e-20 66.8 In-house 24-299 (302) alignment 
Range on Protein: 2215-2487
Range on HMM: 24-299/302.0
DQGIPSKELENLQELK-PLDQCLIgqTKENRRKNRYKNILPYDATRVPLG-DEGGYINASFIKIP-VGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVI
|..   || ......| .|..| .   |.| .||. ...  .|...| |.  .  |.||| ...| .... ..    .   .. | .||.|....| . .
dtaevkkefkkidtmkvdlekCka..fkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

AMMTQEVEGEKiKCQRYWPNILGK----TTMVSNRLRLALVRMQQlKGFVVRAMTlEDIQTREVRHISHLnfTAWPDHDTPSQPDDLLTFISYM--RHIH
 .. .| | .|   . ..|.  |.     .|  |  .   .  .. . .|.  .  |..    .  . .|  | |...  | .  .| . .  .  ..|.
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlP.egcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkik

RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL-YVLTRLQAEEEQKQQP
 . ...     |.|| |...   |..  . .. .  |...|. .| ||  .|.. .||.. | ..| |...... .||.|.. 
adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkke
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2240-2470 3.9e-20 66.6 In-house 44-275 (303) alignment 
Range on Protein: 2240-2470
Range on HMM: 44-275/303.0
TKENRRKNRYKNILPYDATRVPLGDEgGYINASFIKIPVGKEEfvyIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMV
  .|  |||. ...  | ..| | |   || ||....   |     |  | ||. |  |||||| |||  .. ..  . | .|.  .  .|.      . 
fvknmdknrfvdvicldhskvklsds.syihasyleldsskka...iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

SNRLRLAL-VRMQQLKGFVVRAMTLEDIQTREVRHISHlnFTAWPDHDTPSQ-----PDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVV-LG
   .|.    |..  .|.|.. ... . . .   |. |  . |||  . ||.       ..    |..|.   | | .    .| ||.||.  ..   | 
ersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LISQDldfDISDLVRCMRLQRHGM---VQTEDQYIFCYQVI
| |..      |||.|.   | |    ||   |. . | ..
lhseq...asldlvkclenvrngrlhavqnlsqfsvvytll
PDZ PDZ domain (Also known as DHR or GLGF) 1795-1871 1.9e-19 59.8 Pfam-A 2-80 (81) alignment 
Range on Protein: 1795-1871
Range on HMM: 2-80/81.0
ITLIKSEKGSLGFTVTKGNQR--IGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI
..| |.. |.|||..  |.     |..| .| ...|   . ||.||....||..||.|..| .||.... ....|.|.|
vslekekrgglGfslkggsdkrdkgifvsevvpggaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevtLti
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2287-2477 3.1e-19 64.1 In-house 39-224 (255) alignment 
Range on Protein: 2287-2477
Range on HMM: 39-224/255.0
AcqgplptTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNrlrLALVRMQQLKGFVVRAMTLEDIQT--REVRHISHLNFTAWPD
        ||  |.|.|  .|..|..|..   | .. ||..|.|  . .  ....   ....  .     |.|....    .  .. . . | ... |..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad...vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWie

HDTPSQPDDLLTFisyMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGL------ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL
. .| .. ..|     .. .. | ... |||.||||| ... ...|          ..  ..|   |.. .| .|.. ..|  |  |.  ..| ..   
knaPelareilni...lkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2283-2469 7.3e-19 62.7 In-house 5-199 (199) alignment 
Range on Protein: 2283-2469
Range on HMM: 5-199/199.0
FVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVsNRLRLALVRMQQLKGFVVRAMTLEDIQT--REVRHISHLNFT
  |||.| ||  |. |||||.||  |  | |. ..    .     |||     |.     | ..   .     ... |. | .  |     | ||| .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.gslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHDTPSQpDDLLTFISYMRHIH------RSGPIITHCSAGIGRSGTLICIDVVLGL--ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQV
.| .. ||     .. |.   | .       .  |.| ||| | | .| ....|. .     |.    |. .. . .|  | |.. . ..| | |||
swkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2284-2469 7.9e-19 62.6 In-house 5-198 (198) alignment 
Range on Protein: 2284-2469
Range on HMM: 5-198/198.0
VYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVsNRLRLALVRMQQLKGFVVRAMTLEDIQT--REVRHISHLNFTA
 |||.| ||  |. |||||.||  |  | |. ..    .     |||     |.     | ..   .     ... |. | .  |     | ||| .||.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgky.gslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHDTPSQpDDLLTFISYMRHIH------RSGPIITHCSAGIGRSGTLICIDVVLGL--ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQV
| .. ||     .. |.   | .       .  |.| ||| | | .| ....|. .     |.    |. .. . .|  | |.. . ..| | |||
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_eak_pd Subfamily eak 2225-2477 8.2e-18 58.9 In-house 34-309 (332) alignment 
Range on Protein: 2225-2477
Range on HMM: 34-309/332.0
NLQELKPLDQCLIGQTKENRRKNrYKNILPYDATRVPLG----DEGGYINASFIKIP-VGKEefvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVE
.|.. ..|     ..  |. ..|   .|.|||   | |     .. |||||| .. . ||..   ||    .  . |  ||||. ||||  | .. ..||
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrk...yiltGiasedkvfafwqmvleqkspaivqlledve

GEKIKCQRYWPNilgKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLL-------------------TFISY
 .  | ..|.|.   ||  . .   | . | . .|  ...   ||  .  |  .. | ..  | . ..|   | |                     . |.
lkleksdkyfpd...ktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsst

MRHIHRSGPI---ITHCSAGIGRSGTLICIDVVLGLISQDL--DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL-YVLTRL
... . . |    |  .. |  |.|... ||... || .     . . ||.  .. .|   | .. |. | |...| |.|.| 
lkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_hpo-7_pd Subfamily hpo-7 2293-2483 1.6e-16 55.0 In-house 44-236 (263) alignment 
Range on Protein: 2293-2483
Range on HMM: 44-236/263.0
PTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNrLRLALVRMQQlkGFVVRAMTLEDIQ--TREVRHISHLNFTAWPDHDTPSQ
  |.  |.|.|  .|..|..|..   | .. ||..|.|  . .  .. | . ..  ..|.    ....  |  .    .... . |  .. |...  | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan.vnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PDDLLTFISYMRHIhrsGPIITHCSAGIGRSGTLICIDVVLGL------ISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQ
. . |  .   |.     ... |||.|||||     ...|          ..  ..|   |.. .| .|.. ..|  |  |   ..| ..    |..| 
areilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2231-2359 1.9e-14 47.7 In-house 36-181 (349) alignment 
Range on Protein: 2231-2359
Range on HMM: 36-181/349.0
PLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD-------------------EGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVI
. |   . .  |   |||||.||||. .|| |                        |||| ..|..  . |. ||| | |||.|| ||...|  ..  ..
eiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

AMMTQEVEGEKIKCQRYWPNILGKTTMVsnRLRLALVRMQQLKGFVVR
  .... | .  ||..|| .   .   |  .|. .   . ...| ..|
lsLnddkelslekcdiywqelsysnitv..klqnsslyianvqGnslr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2374-2478 3.8e-14 47.2 In-house 217-347 (350) alignment 
Range on Protein: 2374-2478
Range on HMM: 217-347/350.0
ISHLNFTAWPDHDTPSQPDDLLTFIS--------YMRH----IHRSGPIITHCSAGIGRSGTLICIDVVLG---L---I---SQDLDF------DISDLV
. .|..  |.|  .  .| ..|. .          . .      || ||. |||||.|| |||. .| .|        .   |. ||        || .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RCMRLQRHGMVQTEDQYIFCYQVILYVlTRLQ
  .| ||  |||. ||.||.|. .|.   .|.
nelrkqrismvqnldqfifiYeallfy.faLr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2366-2473 1.6e-13 44.8 In-house 83-193 (440) alignment 
Range on Protein: 2366-2473
Range on HMM: 83-193/440.0
IQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHI---HRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQ
|.  | | . . .. .|||.  |     .| .|  . .      .||.. ||||| ||.| .|..| .|    .  . ||  .. .|| .|  |||| .|
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeq

YIFCYQVILYV
| | ....|  
yafvheavleg
PDZ PDZ domain (Also known as DHR or GLGF) 1508-1589 3.1e-13 39.8 Pfam-A 2-78 (81) alignment 
Range on Protein: 1508-1589
Range on HMM: 2-78/81.0
VKLFK-NSSGLGFSFSREDNLIpeqinASIVRVKKLFPGqPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL
|.| | . .||||| .....       .  . |... || .||| ... .||.||.||| .. ..|. |.. |..|.  || |
vslekekrgglGfslkggsdkr.....dkgifvsevvpg.gaaeadglkeGDkIlsvNgvdvenvshdeavqaikgkkgevtL
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2404-2472 1.1e-12 42.4 In-house 225-293 (297) alignment 
Range on Protein: 2404-2472
Range on HMM: 225-293/297.0
IHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
  |. ... |||||.|||| ..  ||.|  . ..   |.  ... .| ||  .||| .|. ..|...| 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 2403-2470 1.3e-12 42.0 In-house 243-311 (319) alignment 
Range on Protein: 2403-2470
Range on HMM: 243-311/319.0
HIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD-LDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
. .. ||.. ||| |.||.|..|  |. .  . .     || .||  .| .|   |.| .|| | |.|.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_PTPDC1_pd Subfamily PTPDC1 2372-2475 7.6e-10 33.5 In-house 81-177 (182) alignment 
Range on Protein: 2372-2475
Range on HMM: 81-177/182.0
RHISHLNFtAWPDHDTPSqPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLgliSQdlDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVIL
..| . || .|.|....|  . .|. .  .    . | .  || || || | ||.  .|    ..  ... .. .. .| .|   .|| .|  .. .  |
qgiyvynf.gwkDygvas.leriLdivkvvafalqegkvavhChaGlGrtGvliacylvy...ak..rltaekaiklvrskrpksiqtreqvelvkefal

YVLT
... 
flip
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2241-2331 7.7e-10 32.8 In-house 94-180 (244) alignment 
Range on Protein: 2241-2331
Range on HMM: 94-180/244.0
KENRRKNRYKNILPYDATRVPLGDE---GGYINASFIKIpVGKEeFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTqEVEGEkikcQRYWPN
 .|  |||    ||.|  ||||        ||||||.   .|.    ||  | ||  |  |||.|. |..  |. ..   || |    . |||.
pnnswknregaglpfdfnrvplskgsmgntyinasfvgc.lgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvlg.sveee....deywpd
PDZ PDZ domain (Also known as DHR or GLGF) 1895-1960 2e-09 27.7 Pfam-A 8-72 (81) alignment 
Range on Protein: 1895-1960
Range on HMM: 8-72/81.0
NKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGnLQLLDVIHYVNGVSTQGMTLEEVNRALDMS
. ..||||| || |   . ...|...| . |.  | |.  |.|  ||||.. .....|.  |. ..
krgglGfslkggsdkrdkgifvsevvpggaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgk
0038934 (Phosphotyrosine protein) phosphatases II 2381-2469 2e-09 32.8 In-house 86-172 (194) alignment 
Range on Protein: 2381-2469
Range on HMM: 86-172/194.0
AWPDHDTPSQPDDLLTFISYMRHIHRS---GPIITHCSAGIGRSGTLICIDVVLGlisqdLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQV
 .||. |. . . ||.|.. . ....    | .  || ||.||.|||..   .       |...  . .. .|  | |.... |..   .. 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2241-2323 2.6e-09 31.1 In-house 35-125 (347) alignment 
Range on Protein: 2241-2323
Range on HMM: 35-125/347.0
KENRRKNRYKNILPYDATRVPL----------GDEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKI
. .  ||| |.    ||||| |           |  .||||| ||.   ..|  ||  | ||| || |||.|.   | | .  . . .. | |
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaske..yiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2411-2470 5.4e-09 30.3 In-house 2-61 (69) alignment 
Range on Protein: 2411-2470
Range on HMM: 2-61/69.0
ITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
. |||.| ||.||.|.| | .  |  .   || . |. ||  |  ||  | .||| .  .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2412-2470 1.2e-08 29.2 In-house 2-60 (69) alignment 
Range on Protein: 2412-2470
Range on HMM: 2-60/69.0
THCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI
 |||.| ||.||.| | | .  |  .   || . |. ||  |  ||  |..|.| .. .
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
PDZ_2 PDZ domain 1804-1871 1.7e-08 23.8 Pfam-A 2-69 (82) alignment 
Range on Protein: 1804-1871
Range on HMM: 2-69/82.0
SLGFTVTKGNQRIGCYVHDVIQD-PAKSDGrLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI
 .| .|.. ... |..| .| .. ||.  | ||||| ..||....|.. |. . . |   . .||.| .
diGvsvsqlentrgvlvvsVkessPaakag.lkpGDiilkvdgkkvksltdlkslllkkkpGdtvkltv
PDZ_2 PDZ domain 1516-1583 2e-08 23.6 Pfam-A 2-59 (82) alignment 
Range on Protein: 1516-1583
Range on HMM: 2-59/82.0
GLGFSFSREDNlipeqinASIVRVKKLFPGQPAAESGkIDVGDVILKVNGASLkgLSQQEVISALRGT
..| |.| ..|       .. |.| .  ...|||..| . .||.||||.|  .   |.....|.|...
diGvsvsqlen.......trgvlvvsVkessPaakag.lkpGDiilkvdgkkv..ksltdlkslllkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2405-2472 3.4e-08 27.2 In-house 263-342 (349) alignment 
Range on Protein: 2405-2472
Range on HMM: 263-342/349.0
HRSGPIITHCSAGIGRSGTLICIDVVLGLIS-----------QDLDFD-ISDLVRCMRLQRHGMVQTEDQYIFCYQVILY
 .. ... ||||| ||.|.|. .|..| ...           | | .| ||  |  .| ||  |||   |.|..|. .| 
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2237-2290 3.6e-07 24.3 In-house 42-95 (95) alignment 
Range on Protein: 2237-2290
Range on HMM: 42-95/95.0
IGQTKENRRKNRYKNILPYDATRVPLGD--EGGYINASFIKIPVGKEefVYIACQG
.| .. |  |||. ||.||||||| |    .  |||| |.     |.  .|||.||
vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkn..cyiaaqg
PDZ_2 PDZ domain 1391-1449 7.5e-07 18.6 Pfam-A 4-63 (82) alignment 
Range on Protein: 1391-1449
Range on HMM: 4-63/82.0
GVNTSVR--HGGIYVKAVIPQGAAESDGrIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ
||..| .   .|..|  | ... |.  | ...|| .|.|.|. ..  |. . .      |.
GvsvsqlentrgvlvvsVkessPaakag.lkpGDiilkvdgkkvksltdlkslllkkkpGd
PDZ_2 PDZ domain 1119-1161 1.8e-06 17.4 Pfam-A 12-49 (82) alignment 
Range on Protein: 1119-1161
Range on HMM: 12-49/82.0
KmgrlDLGIFISSVAPGGPADLDGcLKPGDRLISVNSVSLEGV
.    . |. . ||....||.  | ||||| ...|. . .. .
n....trgvlvvsVkessPaakag.lkpGDiilkvdgkkvksl
subfamily_CDC14_pd Subfamily CDC14 2394-2466 2.1e-06 21.8 In-house 252-318 (328) alignment 
Range on Protein: 2394-2466
Range on HMM: 252-318/328.0
LLTFISYMRHIhrSGPIITHCSAGIGRSGTLICIDVVlglisQDLDFDISDLVRCMRLQRHGMVQTEDQ-YIFC
.  |.. . ..  .| |. || ||.|| ||||   ..     ..  |  .. .  .|. | |.| .  | ..  
vkkfleiaeka..eGaiavhCkaGLGrtGtLiacylm.....khyrftaaeaiawlricrPGsvigpqqkflee
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2253-2331 5.5e-06 20.7 In-house 3-71 (130) alignment 
Range on Protein: 2253-2331
Range on HMM: 3-71/130.0
LPYDATRVPlgdEGGYINASFIKIPVGKEEfvYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTqEVEGEkikcQRYWPN
|... .|..   .  ||||||. .     |  |.  | ||  |  |||.|. |.   |. ..   || |    . |||.
lefevsrlq...gntyinasfvGllgrtae..ylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpd
PTEN_1 2358-2426 8.4e-06 20.7 In-house 72-149 (196) alignment 
Range on Protein: 2358-2426
Range on HMM: 72-149/196.0
VRAMTLEDI--QTR-----EVRHISHLNFtAWPDHDTPSQPDdLLTFISYMRHIHR----SGPIITHCSAGIGRSGTLIC
|.    |..  ...     . .....|.|  ..|| .||    |. ..  . .  .     . .. || ||.|||||...
vnlseeeelsgrsydleeffksgveylhf.pieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva