Gene PTPN14 in Homo sapiens

Synonym: PEZ, PTP36, RP11-176D17.1, PTPN14

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP076_AA protein Get Run
HsapP076_AA_891-1182 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 886-1185 1.1e-162 535.1 In-house 2-300 (300) alignment 
Range on Protein: 886-1185
Range on HMM: 2-300/300.0
VDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGP
..|||...|.|...|.||||||.||||||.||||......|||.||||||..|...|.|||.|||||.|||||.|||||||.|||.|||.|..||..|||
eeatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgP

LPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPED
|..|..|||||||||||..|.|.|.|||.|..||..|.|||.||......|||||||||..|| ...|||||.|||.|..||||||||||||||||.|||
leltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

VQGFLSYLEEIQSVRRHTNSMLEGtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSR
|.||||||||.|||||.|||. |. |...||..||||||||||||||||.|.|..|||||.......|. ||||||...||.|||||||.|||..|.|||
vkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
0050432 (Phosphotyrosine protein) phosphatases II 881-1183 4e-91 300.9 In-house 16-301 (308) alignment 
Range on Protein: 881-1183
Range on HMM: 16-301/308.0
REENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptkENNTGYINASHIKVVVGGAEWHYI
...  |  .......  . |.|.|. |....|.|.....| .. .|.|.|||| .. | . ..||. .|| |    .....|||||.... . . ....|
dtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfI

ATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGsKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH
|||||||.|..|||.|||||.|.|| |.| ..| || | ..|||    ...| .||||.||..  .    | .. |....| .|..|||.|..||.||||
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel.gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdh

GCPEDVQGFLSYLEEIQSVRrhtnsmlegtknRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF
|.|.... .|..||......            ...||||||||||||||..|. .|.. .||.. .| |. ... |||||..|.||  ||.|.|..|. .
gvPpspeilldflelvrksl............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

LQN
|..
lkl
0051299 (Phosphotyrosine protein) phosphatases II 905-1181 1e-86 286.3 In-house 21-286 (288) alignment 
Range on Protein: 905-1181
Range on HMM: 21-286/288.0
EEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVN
   ... |.|......... .|.|.|||| |. | . ..||. .|| | .... ....|||||.|..   . .  .||||||||.|..|||.|||||.|.
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvr

VIAMVTAEEEGGRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHL----LSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSV
|| |.| ..| ||.|...|||     ..| |||...||..  .    | .. |.|..|     .|..|||.|..||.|||||.|.... .|..|......
vIvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

RRhtnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
..          ....|.||||||||||||..|. .|....||....|.|. ... |||||..|.||  ||.|||..|. .|
la..........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 901-1183 6.3e-85 280.4 In-house 7-279 (297) alignment 
Range on Protein: 901-1183
Range on HMM: 7-279/297.0
KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIkvVVGGAEWHYIATQGPLPHTCHDFWQMVWEQ
 |.|   .. .|.|.... ...| .|.|.|||| |. | . ..||. .|| |   ......|||||..   . . . ..||||||||.|..|||.|||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweq

GVNVIAMVTAEEEGGRTKSHRYWPKLgsKHSSATYGKFKVTTKFRTD--SVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQS
.|.|| |.| ..| || | ..|||    . .| |||.|.||..  .   .  | .. |.|... .|..|||.|..||.|||||.||... .|...|....
nvtvIvmltelvelgrekcaqywple..egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

VRRHTnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLE---HNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
|....        ....|..|||||||||.|..|. .||...||   ....| .. ... |||||....||  ||.|.|..|...|..
vlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0046845 (Phosphotyrosine protein) phosphatases II 911-1182 1e-83 276.3 In-house 4-275 (284) alignment 
Range on Protein: 911-1182
Range on HMM: 4-275/284.0
TEYEQIPKKKANG--IFSTAALPENAERSRIREVVPYEENRVELIPTKE--NNTGYINASHIKVVVG---GAEWHYIATQGPLPHTCHDFWQMVWEQGVN
 |.|.... . .    .|.|.|||| .. | . ..||. .|| | ....  ....|||||....        . ..||||||||.|..|||.|||||.|.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIAMVTAEEEGGRTKSHRYWPKLgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLL-SGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRH
|| |.| ..| ||.| ..|||     ... |||.|.||.. ..   .| .. |....|  .|..|||.|..||.|||||.|.... .|..|.........
vIVmltelvengrekcaqYwple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

tnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNE---KVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
         ....||||||||||||||..|. .|....||...   .| |. ... |||||..|.|| .||.|||..|. .|.
........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0047943 (Phosphotyrosine protein) phosphatases II 900-1181 4e-83 274.3 In-house 5-272 (273) alignment 
Range on Protein: 900-1181
Range on HMM: 5-272/273.0
LKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWE
|.|.|  .... |.|.... | .. .|.|.|||| .. |.. ..||. .|| |   ......|||||....   . .  .||||||||.|..|||.||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvwe

QGVNVIAMVTAEEEGGRTKSHRYWPKLGSKhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSV
|.|.|| |.| ..| || | ..|||  | .  | |||||.||..  .   .| .. |....| .|..|||.|..||.|||||.|.... .|...|.....
qnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

RRHTNSMlegtknrhPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
.....|         .|.||||||||||||..|. .|....||.. .| |.  ..|||.||. |.||  ||.|.|..|. .|
lealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 903-1183 1.2e-82 273.1 In-house 14-278 (317) alignment 
Range on Protein: 903-1183
Range on HMM: 14-278/317.0
KLEEGMVFTEYEQIPKKKANgIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVvvGGAEWHYIATQGPLPHTCHDFWQMVWEQG
|.  ...  |.|.... | .  .|.|.|||| .. |.. ..||. .|| | |... ....|||||....       ..||||||||.|..|||.||||||
ksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg..pnlkrkfIatqgPlpntvedFwrmvweqg

VNVIAMVTAEEEGGRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRr
|.|| |.| .|| || |...|||      .. |||.|.||..  .    .  . |.|..| ....|||.|..||.|||||.|.. . .|. ||...... 
vtvivmLteleelgrekcaqYwpl....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.

htnsmlEgtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
      |   ... |..|||||||||||..|. .||...||....| |.  .. |||||. ..|| .||.|.|..|...|..
......e...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_PTPN3_pd Subfamily PTPN3 895-1181 1.4e-82 271.8 In-house 3-275 (280) alignment 
Range on Protein: 895-1181
Range on HMM: 3-275/280.0
ERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVVVGGAE--WHYIATQGPLPHTCHD
| . .||. || |.|....||. .|| .   |.| .|||... | |...||.. ||.|   ||..| ||||..... . ...   .||||||||..|..|
esllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvkl...kesetdyinanyvnmeipstglvnryiatqGPlaktatd

FWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlgsKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSY
|||||||| ...| |.|   | ||.| |.|||.   .. . .||.|.|. . .  .  |..  | .|.  . .||.. .|||..||||| |.| . ||..
fWqmvweqksslivmlttlverGrvkChqyWPe...tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflef

LEEIQSVRrhtnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
.|.....|          . .. |.|||||||.|||||||| |. .  .|..|.| .. ..| .|.||. ..|| .||||| . ...  
vervrklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
0039614 (Phosphotyrosine protein) phosphatases II 893-1183 1.9e-81 269.1 In-house 18-291 (297) alignment 
Range on Protein: 893-1183
Range on HMM: 18-291/297.0
MDERFRTLKKKLEEGMVFTEYEQIPKKKANgiFSTAALPENAERSRIREVVPYEENRVELIPTKE--NNTGYINASHIKVVvGGAEWHYIATQGPLPHTC
. ...  |.|... .....|.|.... | .  .|.|.|||| .. |.....||. .|| | | ..  ... |||||....       ..||||||||.|.
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgy.dlltrkfIatqgPlpetv

HDFWQMVWEQGVNVIAMVTAEEEGGRtKSHRYWPKLGSkhssaTYGKFKVTTKFRTDSVCYATTGLKVKHllSGQERTVWHLQYTDWPDHGCPEDVQGFL
.|||.|||||||.|| |.| ..| || | ..|||  |.     |||.|.||..  .    | .. |.|..  .|..|||.|.|||.|||||.|.... .|
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelll

SYLEEIQSVRRHTnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
. ||.........        ... |..|||||||||||..|.  ||...||.. .| |.  .. |||||. ..||  ||.|.|..|...|..
eflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 908-1182 1.4e-80 266.6 In-house 28-305 (307) alignment 
Range on Protein: 908-1182
Range on HMM: 28-305/307.0
MVFTEYEQIPKKKA--NGIFSTAALPENAERSRIREVVPYEENRVELIPTKE--NNTGYINASHIKVV------VGGAEWHYIATQGPLPHTCHDFWQMV
 .. |.|.... .   .| .|.|.|||| .. |.....||. .|| | ....  ....|||||...|       .     ..||||||||.|..|||.|.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEQGVNVIAMVTAEEEGGRTKSHRYWPKLgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHL-LSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEI
|||||.|| |.| ..| || | ..|||      .. |||.|.||..  .    |  . |.|..|  .|..|||.|..||.|||||.|.... .|. .||.
weqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

QSVRRHtnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK---VEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
......         ... |..|||||||||||..|.  ||...||....   | ..  ..||||||. ..|.  ||.|.|..|...|.
rkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 901-1180 9.8e-79 260.0 In-house 14-276 (278) alignment 
Range on Protein: 901-1180
Range on HMM: 14-276/278.0
KKKLEEGMVFTEYEQIPKKKAnGIFSTAALPENAERSRIREVVPYEENRVELIP-TKENNTGYINASHIKVvvGGAEWHYIATQGPLPHTCHDFWQMVWE
... .  ..  |.|.... |  . .|.|.|||| .. |.. ..||. .|| | . .......|||||....       ..||||||||.|..|||.||||
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFwrmvwe

QGVNVIAMVTAEEEGGRTKSHRYWPklgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSV
.||..| |.| ..| ||.|...|||      .| |||.|.||..  .    | .. |.|..| .|..|||.|..|..|||||.||... .|..|......
lgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

RRhtnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF
..          ... |..|||||||||||..|. .|....||.. .| ..  .. |||||. ..||  ||.|.|..|...
le..........dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 907-1182 1.8e-78 259.6 In-house 23-282 (564) alignment 
Range on Protein: 907-1182
Range on HMM: 23-282/564.0
GMVFTEYEQIPKKkANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI
  ...||..| ..  .  ...|. |.| .. |  ..|.|...|| | ...  ... |||||.|.     .. .||||||||..|..|||.||||| ...|
lkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnssti

AMVTAEEEGGRTKSHRYWPKLgskHsSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRhtns
 |.|  || |..| |.|||.    . ..|||...|| .  ..   |  . .|.|.  | . |.| . ..|.||||| ||  ...|. .........    
VmltkleEkgkvkchkYWPek...g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne....

mlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
      . . ||||||||||||||. |  . |.  ......|..  ....||.|| .|.||  || |..... ..|.
......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0045098 (Phosphotyrosine protein) phosphatases II 904-1182 1.1e-77 256.4 In-house 4-273 (278) alignment 
Range on Protein: 904-1182
Range on HMM: 4-273/278.0
LEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVEliptkenntGYINASHIKVVvggaEWHYIATQGPLPHTCHDFWQMVWEQGVN
| ......|.|...    .. ...| ...|... |.....||. .||          .|||||.|..       ..||||||||.|..|||.|.||.|..
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgit

VIAMVTAEEEGGRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHL----LSGQERTVWHLQYTDWPDHGCPEDV--QGFLSYLEEIQ
|| |.| ..|.|| | ..|||     ..| |||.|.||..  .   .| .. |.| .|     ....|.|.||.|. |||||.|..   . ||..||.|.
vivmltelvelgrekcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

SVRRHTNSMLEGTKN---RHPPIVVHCSAGVGRTGVLILSELMIYCLehNEKVEVPMMLRLLREQRMF-MIQTIAQYKFVYQVLIQFLQ
..... .|.|. ...   .. |..|||||||||||.|..  ||...|  ...| ..  .. ||.||.. ..|.  ||.|.|..|...|.
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
DSPc_SM00195 910-1181 2e-77 255.4 In-house 3-262 (263) alignment 
Range on Protein: 910-1181
Range on HMM: 3-262/263.0
FTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMV
 .|.|.. ... .  ...|. ..| .. | ....||...||.| .... ... ||||..||.     . .|||||||||.|..|||.||||..|..|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TAEEEGGRTKSHRYWPKLGskHSSATYGKFKVTTKFRTDSV-CYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTnsml
| ||| |..| .||||.    ... |.||..|...  .     . .. |....    ..|.| ..||..|||||.|.. . .|..|..... ....    
teeeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

egtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
      ..||||||||||||||.... ....  ||...||..  ... ||.||. |.|| .||.|.|.......
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 910-1181 2e-77 255.4 In-house 3-262 (263) alignment 
Range on Protein: 910-1181
Range on HMM: 3-262/263.0
FTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMV
 .|.|.. ... .  ...|. ..| .. | ....||...||.| .... ... ||||..||.     . .|||||||||.|..|||.||||..|..|.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TAEEEGGRTKSHRYWPKLGskHSSATYGKFKVTTKFRTDSV-CYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTnsml
| ||| |..| .||||.    ... |.||..|...  .     . .. |....    ..|.| ..||..|||||.|.. . .|..|..... ....    
teeeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

egtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
      ..||||||||||||||.... ....  ||...||..  ... ||.||. |.|| .||.|.|.......
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 899-1182 8.2e-76 249.9 In-house 3-270 (273) alignment 
Range on Protein: 899-1182
Range on HMM: 3-270/273.0
TLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptkENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVW
.|.|||....   |.... . |.    ...   || .. | |.|.||.| ||.|    ....||||||.||| ||  |..|||.|||||.|..|||||||
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvkl....gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvw

EQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHsSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQS
|| ..|||||| | |.|. | |||||.  .|.    .....|.    ..   ..   |.||.. ||. | | ||....||||| |   . .| .. |...
eqkaeviamvtlekekgkvkchrywPesknkk.lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr

VRRhtNSMlegtknrhpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
...  ..          |||||||||.||.|.||  . ..  .|......|  ..| |||||  ..||  || |||..... |.
lqt..dag.........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
Y_phosphatase Protein-tyrosine phosphatase 933-1178 3.7e-74 244.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 933-1178
Range on HMM: 1-234/235.0
NAERSRIREVVPYEENRVELIPTKENNTgYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPklGSKHSS
| .. | ....||...||.|  .....  ||||...|      . ..|||||||..|..|||.|||.. |.||.|.| .|| ||.| ..|||   ... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeees

ATYGKFKVTTK--FRTDSVCYATTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRrhtnsmlegtKNRHPPIVVHCSAGVGRTG
 |||..||..|    .|.  |... |..|.  . . .|.|..|.||.|||||.||.....|........ .          .... |.||||||||||||
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtg

VLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLI
.... .... .||..|.|.|  ... ||.||. |.|...||.|.|....
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 933-1178 3.7e-74 244.4 In-house 1-234 (235) alignment 
Range on Protein: 933-1178
Range on HMM: 1-234/235.0
NAERSRIREVVPYEENRVELIPTKENNTgYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPklGSKHSS
| .. | ....||...||.|  .....  ||||...|      . ..|||||||..|..|||.|||.. |.||.|.| .|| ||.| ..|||   ... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeees

ATYGKFKVTTK--FRTDSVCYATTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRrhtnsmlegtKNRHPPIVVHCSAGVGRTG
 |||..||..|    .|.  |... |..|.  . . .|.|..|.||.|||||.||.....|........ .          .... |.||||||||||||
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtg

VLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLI
.... .... .||..|.|.|  ... ||.||. |.|...||.|.|....
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 926-1181 2.7e-73 241.9 In-house 4-246 (249) alignment 
Range on Protein: 926-1181
Range on HMM: 4-246/249.0
STAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP
|.| |||| .. |.. ..||. .|| | .... . ..|||||.|..   . .  .||||||||.|..|||.|.||.|..|| |.| ..| || | ..|||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTnsmlegtkNRHPPIVVHCSAG
      .| .||.|.||..  . .  | .. |....|  |..|||.|.|||||||||.|.... .|...|.........        ... |..||||||
l....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvlVHCsaG

VGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
|||||..|.  ||...||.. .| ..  ..|||.||. ..|.  ||.|.|..|...|
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 925-1181 7.4e-73 240.2 In-house 1-243 (245) alignment 
Range on Protein: 925-1181
Range on HMM: 1-243/245.0
FSTAALPENAERSRIREVVPYEENRVELIPTKENN-TGYINASHIkvVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYW
.|.|.|||| .. |.....||. .|| | |..... ..|||||..   .     ..||||||||.|..|||.|.||.|...| |.| ||| || |...||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHtnsmlegtkNRHPPIVVHCSA
|     ..| |||.|.||..  .    | .. |.|..| ....|.|.|..|..|||||.|.... .|. ||.......          ... |..|||||
pl....gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlVHCsa

GVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
||||||..|.  ||...||.. .| ..  .. ||.||. ..||  ||.|.|..|...|
GvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 897-1183 8.7e-72 236.6 In-house 6-278 (281) alignment 
Range on Protein: 897-1183
Range on HMM: 6-278/281.0
FRTLKKKLEEGMVfTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQ
...|... ..|.. .|||.. .   .   . .  .|| .. | . .| |.  ||.. |..| .|| ||||.... . | .|  |||||||.|.....|||
lkqlsqndnaGfi.eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPvPaslvafWq

MVWEQGVNVIAMVTAEEEGGRTKSHRYWPklgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVkHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEE
||||| |..|.|||.| |.|. | |||||    ..|. .||...|... ....  |..  .|. .  ||..|.| .|.|| ||||| |.. . .|.. .|
mvweqkvsaivmvtreieagklkChrYWP...ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrke

IQSVRRHTNSmlegtknrhPPIVVHCSAGVGRTGVLIL-SELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
....... .           |.|.||||||||||. |    |.  . ...|...|  ... ||..|..|.||..||.|||..... |..
vlkltekktk.........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN6_pd Subfamily PTPN6 902-1185 5.1e-71 234.2 In-house 21-301 (306) alignment 
Range on Protein: 902-1185
Range on HMM: 21-301/306.0
KKLEEGMVFTEYEQIPKKKANGIFST--AALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWE
..||   .  |.|.. ...|.  .|   .| |||.|. |.. ..|....|| |   .  .. ||||. ||  | | . .|||||| |..|  |||.|||.
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

QGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSsatYGKFKVTTKFRTDSVCYATTGLKVKH-LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQS
.  .|| |.| | | |. |  ||||.  .|..   ||| .||.   ..   |    |.|..   ...||.|.......|||||.|.| . .|..||....
ensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

VRRHTNSMlegtknRHPPIVVHCSAGVGRTGVLILSELMIYCLEHN---EKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSR
 .......      .. |||||||||.|||| .|. ....  .|..    ....  . ...||||  ..|| .||||||... .......
kqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPRB_pd Subfamily PTPRB 907-1184 2.1e-69 228.8 In-house 25-288 (293) alignment 
Range on Protein: 907-1184
Range on HMM: 25-288/293.0
GMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVI
  .  |||.. . . .   ..| |..|... | ....||...||.| ..|. ... ||||..|.      . ..||||||||.| .|||.||||. ...|
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns..prefiatqGPlpetvddfWrmvwekkssii

AMVTAEEEGGRTKSHRYWPKlgsKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHllSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHtns
 |.|.  |.|..| ..|||.   .... .||. ||| .  ..   ...  ||...  . .||.| ....| ||||| ||. . .|......... ..   
vmltqlvekgkvkCeeYWPa...deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek...

mlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNS
     .... ||||||||||||||..|  . ..  .|... |..  ..  |||.|....|| .|| |..|.....|...
.....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 895-1182 2.9e-69 228.6 In-house 9-281 (318) alignment 
Range on Protein: 895-1182
Range on HMM: 9-281/318.0
ERFRTLKKkLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDF
.. | |..   | ....|||.. .....     .  | |. . |   ...|.. ||.| .... ... ||||..|      ..  |||.|.|||.|..||
shvrrlre.sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr..rkkayiaaqaPlpetieDf

WQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGskhsSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYL
|.|||||.  || |.| ||| |..| |||||. |    | .||| .|. | ....  |    .||..  . ..|.|   .||.|||.| ||.. ..|. .
WrmvWeqnsavivmltqeeergkakvhryWPskg....srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

EEIQSVRRhtnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
 ..... .         |. . ||||||||||||||| |  . ..  ..... |.|  . . |||||  |.||  ||.|.|.||...|.
rqvskaqq.........ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
0037934 (Phosphotyrosine protein) phosphatases II 926-1180 3.2e-69 228.5 In-house 3-241 (243) alignment 
Range on Protein: 926-1180
Range on HMM: 3-241/243.0
STAALPENAERSRIREVVPYEENRVELiptkeNNTGYINASHIKVVvGgaewHYIATQGPLPHTCHD----FWQMVWEQGVNVIAMVTAEEEGGRTKSHR
|.| |||| .. | . ..||. .|| |     ....||||..|.|. .    ..||||||||.|..|    ||.|.||.|..|| |.| ..| || | ..
siallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.p....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPklgskhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLL-SGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLegTKNRHPPIVVH
|||      .. |||.|.||..  .    |  . |....|  ....|.|.|..|. |||||.|.... .|..|.|.... . ..|.|  . ... |..||
ywp......gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll..aldsggpvlVH

CSAGVGRTGVLILSELMIYCLehneKVEVPMMLRLLREQRMF-MIQTIAQYKFVYQVLIQF
|||||||||.||.  ||...|    .| .   ..||||||.. ..||  ||.|.|..|...
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN9_pd Subfamily PTPN9 901-1184 8.4e-69 226.8 In-house 11-293 (297) alignment 
Range on Protein: 901-1184
Range on HMM: 11-293/297.0
KKKLEEGmVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWE
|.| ..| .  ||..| .....| | .. |. | |. |  .|. |.| || |  ..|. .. ||||...       .  .|||||||..|..|||.||||
kekgkrG.lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWe

QGVNVIAMVTAEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSV
| | || |.|  .| || |  .|||.  ...||| .|...|..     .  | .. |..|.   ...|.| | |.. |||.| |.. . .|  ||.... 
qevlvivmttrvvergrlkcgqyWpl..eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

RRHTNSMLEGT---KNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNS
.  . . |  .   . . ||||||||||.|||| .|  .. .  ||. ..|.|   ..|||.|| |.|||  ||.| |. .... ...
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 909-1181 2.6e-63 208.8 In-house 23-279 (288) alignment 
Range on Protein: 909-1181
Range on HMM: 23-279/288.0
VFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIP-TKENNTGYINASHIKVVvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAM
.  ||..... . .   ... |..||.. | |...||.|.||.|    .|... |||||.|..   . . .||||||||..| .|||..|.|. .. |.|
fseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelvyenktstivm

VTAEEEGGRTKSHRYWPKLGSkhsSATYGKFKVTTKFRTDSVCYATTGLKVKhlLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTnsml
.|.  |||.|| ..|||. .       ||...|| .   .   . .  | ..   ...|... ..||. ||||| ||. . .| .|. ..          
ltelveggktkCeeYWPdadk...pknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad....

egtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
        ||.|||||||||||. |  . .|  .|......|  ..  ||.||....||  || |.|.||..  
......tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN23_pd Subfamily PTPN23 907-1181 4.5e-63 207.8 In-house 18-280 (288) alignment 
Range on Protein: 907-1181
Range on HMM: 18-280/288.0
GMVFTEYEQIPKKKANGiFSTAALPENAERSRIREVVPYEENRVELIptkENNTGYINASHIKVVVGGAEwHYIATQGPLPHTCHDFWQMVWEQGVNVIA
. .| | ||  .|.|.. .|.|.   ..|. | |...||..||| |    ...  |||||..| .. |.  ..||||.||. |  |||.||.|| ..|| 
dkkfkeleqkqdkeark.rsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviV

MVTAEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSM
|.. .|| |..| .||||.  .|  . ..|...|| |  ...  .    ||...| . . ..| |||.| ||..| |.  . .| .|.|..|  ....  
mllskeelgkpkvdrYwPe..dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrk

LEGtknrhpPIVVHCSAGVGRTGVLILSELMIYCL-EHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
..       |.|||||||||||||. |    .  | ..|  .... ... ||||| ||.|. .|.||.|.. ..  
skt......PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN12_pd Subfamily PTPN12 919-1183 1.8e-62 205.9 In-house 24-279 (290) alignment 
Range on Protein: 919-1183
Range on HMM: 24-279/290.0
KKANGIFST--AALPENAERSRIREVVPYEENRVELIPTKENN-TGYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGG
 ||. ..||  .  .|| .. | ....||...||||  ..|..  .||||..|| | |  . .|||.|||||.| .|||.|.||. |... |.  | | |
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

RTKSHRYWPKLGSKhsSATYGKFKVTTKFRTDSV-CYATTGLKVKHLlsGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeIQSVRRHTNsmlegtkNRH
..| .||||. | .  . ..|.|.||..        .    |||..   ...|.|  ..||.|||||.|. ..  |.    |..||.. .       . .
kkkCerYWpeegee..elefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllel...ielvrelqe.......sed

PPIVVHCSAGVGRTGVLILSELMIYCLEHN---EKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
 |.||||||||||||..|  ...   |...   |...|  ... ||.||  ..||  ||..||. .....|.
aPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 929-1183 9.6e-61 200.1 In-house 13-266 (270) alignment 
Range on Protein: 929-1183
Range on HMM: 13-266/270.0
ALPE---NAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP
.|||   ...  | ....|  . || | . .|. .| |||| ... .  |.. .|||..|||| | ..||.|.||. |. |.|.|  || ||.|  ||||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGf.dgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

KLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKhlLSGQERTVWHLQYTDWPDHGCPEDVQGFLS---YLEEIQSVRRHTNSMlegtKNRHpPIVVHC
.   .. . ..|| ||..   . .  | .| |...   .|.|| . | .|..||||| |.. .. ||    |. .. |||.....    .. . |..|||
aepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekel....dkae.PllvHc

SAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
||||||||.||. . .. .||...||.|  ... ||..|| ..|.  ||.|.|...... . 
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRG_pd Subfamily PTPRG 911-1182 3.5e-60 198.8 In-house 23-288 (563) alignment 
Range on Protein: 911-1182
Range on HMM: 23-288/563.0
TEYEQIPKKKANG--IFSTAALPENAERSRIREVVPYEENRVELIPTKE--NNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIA
 |.|.. .. ..     ...  ||| .. |  ..|.|.. ||.| |. .  ..  ||||..|.    . .  .|||||||..|..|||.|.||| |..| 
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiiv

MVTAEEEGGRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHL--LSGQ----ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvr
|.|  .| || | ..||||      | |||...|| . .   ..|..  |..|.|    ..    |..| . .||.||||| ||     |.. .      
mitnlvergrrkcdvYWPk....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks....

rhtnsmLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
         .|.   ||||||||||||||..|  . ..  ......|.|  .|. .| || |..||. || |....|.. ..
......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 907-1182 4.5e-60 198.4 In-house 27-291 (298) alignment 
Range on Protein: 907-1182
Range on HMM: 27-291/298.0
GMVFTEYEQIPKKKA---NGIFSTAALPENAERSRIREVVPYEENRVELIP-TKENNTGYINASHIKVVVGGAewHYIATQGPLPHTCHDFWQMVWEQGV
    .|.... . .    .   . |  ||| .. |  ......  || |    ..... |||||...   |     .||||.||..| .|||.||.|. .
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedi

NVIAMVTAEEEGGRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRh
..| |.|  || ..|| |.|||.    . ..|||...|. . . .   .... |||..  . .||.| .|..| |||.| ||  .  | .|....  .. 
gtiVmltnleeldktkyhkywPd....egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq.

tnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
        .. . |..|.|||||||.|  |  . ..  ......|.|  ... ||..|. ..|| .||.|.|.. ...|.
........qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Ptp69D_pd Subfamily Ptp69D 890-1182 1e-59 197.2 In-house 6-287 (307) alignment 
Range on Protein: 890-1182
Range on HMM: 6-287/307.0
RVPMDERFRTLKKKLEEGMVFtEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVggAEWHYIATQGPLPH
.. ..| ... |.. ..|..  |||...... .   ....  ||| . |  ........|| | ... .... |||||.||      . ..|| |.|.  
iddleealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk..ekkkfiaaqdPvea

TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLgskhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLL-----SGQERTVWHLQYTDWPDHGCP
| .|||.|..|| |..| |.. ..|  | | ..|||.         ||.  |..        |.   |.| .         ..| |   .|| |.|   |
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

EDVQGFLSYLEEIQSVRRHTnsmlegtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|  .| | ..|..... ..           . ||||||||||||.|...  ....  |. ..||..  . . ||.|| ...| ..||.|.|. |... .
evargllklieqvrelykln..........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 907-1182 9.1e-59 194.1 In-house 23-284 (319) alignment 
Range on Protein: 907-1182
Range on HMM: 23-284/319.0
GMVFTEYEQIPKKKANgIFSTAALPENAERSRIREVVPYEENRVELIPTKE-NNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI
 ..  |.... . ...  |..|  .|| .. | .....|.  || | . .. ... |||||.|       .  .||||.|| .| .|||.||||... ..
tllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq..erekfiatqaPlentiedfWrmvWeeessiv

AMVTAEEEGGRTKSHRYWPKLgskhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQ-ERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTN
 |.|   | .. | ..|||.        .||.. || . .     |    ||.... |    |.| | |||.||||. ||. .. |  |..|.  |..|.
vmltklveklkvklkkywpee....nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq

SMlegtknrhpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|          ||||||||||||||  |  . |.  ..... ..|  . . || || .|.|. .||||.|..|.....
sg.........PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 912-1183 9.3e-59 193.7 In-house 10-270 (274) alignment 
Range on Protein: 912-1183
Range on HMM: 10-270/274.0
EYEQIPKKKangIFSTAALPENAERSRIREVVPYEENRVELIPTK--ENNTGYINASHIKVVvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVT
|. ..|            .. .... | ....| |. || | . .  .... |||| .||   .. .  |.|||||||.| .|||.|.... |.|| |.|
eflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPlpntvadfWrmiyqeevqvivmlt

AEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSgqERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEG
  .|  ..| ..|.|.  . . | .||.......  ..   |  . | .|.| .  ||.| |  |||||||  |.|.. .|. ..|... |...|  |  
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklap

TknrhppiVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
.       |||||||.||||. |  .. .  |.....|.|  .   || .|  |.||  ||......|...|..
v.......vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRA_pd Subfamily PTPRA 909-1180 1.4e-58 193.4 In-house 34-294 (330) alignment 
Range on Protein: 909-1180
Range on HMM: 34-294/330.0
VFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAM
.  |.. .|  . .. . .|.  || |..|. ...||. .|| | . . .... |||||.|.        ..||.|||. .| .|||.|.|||    | |
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksativm

VTAEEEGGRTKSHRYWPKLGSkhssATYGKFKVTTKFRTDSVCYATTGLKVKHLLS----GQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHT
.|  .|  ..| ..|||. |.     |||. .|. .  | .| |.   . |..|       ..| |  . .| ||| | | . .| |..|........ .
ltelkerkeekcaqywPdeGl....vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

NsmlegtkNrhpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF
        .   |||||||||||||| .|  . ..  .. ..||.|  ... || ||  |.||  ||.|.|.|| ..
a.......g...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 911-1182 6.2e-58 191.3 In-house 26-284 (305) alignment 
Range on Protein: 911-1182
Range on HMM: 26-284/305.0
TEYEQIPKKkaNGIFSTAALPENAERSRIREVVPYEENRVELIPTKENN-TGYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVT
..|......  .  .      .|....| .|.......|. | ...... . |||||...   .  . .||..||||..| .|||....|  |..| |.|
aqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr..kkkyivaqgPlkntvadfWrliveekvstivmlt

AEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH-LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQsvrRHTNsmle
   |||. | ..|||.  ||  .  .|.|.|. | ..    | .  ||.     . ..||| ..| ||||||| |.    .|| ....|   .. .    
klveggkdkCrqYWpe..sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq...kdqk....

gtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
  |..  |..|||||||||||| |  ....  |.. | |.|  .|. ||..|| |.|| .|| |....| . ..
..kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 928-1182 2.7e-54 179.0 In-house 4-243 (250) alignment 
Range on Protein: 928-1182
Range on HMM: 4-243/250.0
AALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVGGaeWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTkSHRYWPKl
|  |.| |. |  ....... || | ..| .... |||||....  .     .|||||||..|  |||.||.|. ...| |.|  .| ..|  |.|||  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.

gskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMlegtknrhpPIVVHCSAGVG
     . .||. .|. . .     | .. ||. .    .||.| .|... ||| | ||  .  | .|...|. ......          |..|.||||||
...ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagna.........PvivqCsaGvg

RTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|.|  |  . ..  |.....|.|  ... ||..|. .... .|| |||......|.
rsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 911-1179 3.6e-54 178.6 In-house 11-293 (297) alignment 
Range on Protein: 911-1179
Range on HMM: 11-293/297.0
TEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKeNNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTA
.|.. . ...  . ||.|  .    . | |... ....|| |  .   .. |||| ..      |. .|| .||||  | .|||..|.||.|.||.||. 
aekdllldeargesfssakrnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

EEEGGRTKSHRYWPKLGSKHSSAtyGKFKVTT--KFRTDSVCYATTGLKVKHLlsGQERTVWHLQYTDWPDHGCP---EDVQGF--------------LS
 .|.|| |   |||.   .   |  |.. |    ..  .      | |.. .    ..| | | |.  ||||| |   ||.. |              |.
lqedGrdkcapywpsvvqerlka..gdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmla

YLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
 .| . ..       |.  . |  ...|||||||||.||..||. ..  | ..   .|  .|. |||||  ..||. |....|.. ..
lvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPN1_pd Subfamily PTPN1 913-1179 7.1e-54 177.5 In-house 12-269 (290) alignment 
Range on Protein: 913-1179
Range on HMM: 12-269/290.0
YEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVvvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEE
|..| |.  .   ..| |||| .. | |.| ||.  |..|   ..... ||||| ...    |. .|| ||||||.|.  ||||||||    . |.    
yldirkeasdfptreaklpenrnlnryrdvspydhsrikl...eradndyinaslvel..eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EGGRTKSHRYWPKLGS-KHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvRRhTNSMlegtK
| ...| ..|||.  . |       |.||.   . ..  |    |... | . . |.. |  || ||| | ||  . ||..| ..   |. . |.    .
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv...re.sGsl....s

NRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK---VEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
. . | |.|||||.||.| ..| . ..  .|....   |..  .|  ||..|. .|||  | .| |. ...
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 891-1182 2.3e-52 173.0 In-house 10-285 (297) alignment 
Range on Protein: 891-1182
Range on HMM: 10-285/297.0
VPMDeRFRTLKKKLEEGMVFTEYEQIPkKKANGIFSTAALPE-NAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVGgaewHYIATQGPLPH
.|.   | || .|  .  ||.|  . .  .||   .| |    | |.|| . ..||. .||.|  . .. .  |.|||..|..      ..|.|| | . 
ipls.dfatlvqknrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmka

TCHDFWQMVWEQGVNVIAMVTAEEEGGRtKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPE--DV
|  |||.||... |..|.|.. ..|. . |  |||..    ....|.|.  |...  ..   .    |.|..  . ..| |   |...|||.  ..  ..
tvadfWamvldeqvstivmlnddnerdk.kcaryWsd....kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

QGFLSYLEEIQSVRrhtnsmleGTKNRHpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
. .| ...|.. .         ....   |..|||.|||||||||.  . ..   .....|..  ... ||..|....||  ||||||......| 
ssllklisevrkdf........sqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 898-1179 2.8e-52 173.0 In-house 23-289 (319) alignment 
Range on Protein: 898-1179
Range on HMM: 23-289/319.0
RTLKKKLEEG--MVFTEYEQIPKKKANGIFST-AALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDF
.. |.....    .  |. ...|. .|.   | | |..| .. || .......|.| | ..  |. . |||||...      .  |||.||||. |  ||
lsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq..rkdkyiaaqGPldntladf

WQMVWEQGVNVIAMVTaeeeggRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKH-LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSY
|.|.||. .  | ..|      . |  .|||.    .   ....|||  .  ...  |.   ... .     . | .    .  |||.| |.    ..  
Wrmiweyncstivllt......kdkcsqywpl....kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl

LEEIqsvrRHTNSmlegTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
.. .    || .|     .| . .|||||||||||||| |  . ..  ......|.|  ..| ||.||  ..| ..||||.|  |..
vkkv....rhlts....kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 906-1182 7.6e-52 171.1 In-house 18-278 (315) alignment 
Range on Protein: 906-1182
Range on HMM: 18-278/315.0
EGMVFTEYEQIPKKKANGIfSTAALPENAERSRIREVVPYEENRVEL-IPTKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNV
  ..  |. ..|  ..     .|  ..| .. | ....|....|| | .  .. .  |||||.|| |    .  |||.||||. .  |||.||... |  
talfseefhdlpdPdiyrq.rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd..ddkayiasqgPlkasvddfwrmvlqekvtt

IAMVTAEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTkFRTDSvCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQgflSYLEEIQSVRRHtN
|.|||  .|| . |  .|||.   |  |. .|..||.. . ... .  ..  |.    | . |||   |.|.|||.| ....    | |. |. |.   |
ivmvtkkqegdkikcrqywPd..rkadsvefGsikvel.lslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts...sllklikevkad.n

smlegTKNRHpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
      |. . ...||||||||||||.|  . ..  ..... |.|  ... ||..|....||  .| |.|... . |.
.....gkkef.sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRK_pd Subfamily PTPRK 911-1179 5.5e-51 168.2 In-house 26-275 (314) alignment 
Range on Protein: 911-1179
Range on HMM: 26-275/314.0
TEYEQIPKKkangiFSTAALPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVT
 ||| ...      . .|   || |..|. ....|.  || ||..... .. ||||. |         ..|.|||||..| .|||..|....   | |.|
eeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydencasivmlt

AEEEGGRTKSHRYWPKlgskhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSG--QERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHtnsml
   | || |  .|||.      . .||..||.    .    . .  ..|..|  |  . |.| ..|.. ||||. |   .|.|... .... . .     
elvevgrvkClkyWPe.....dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.....

egtknRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
     .. .|||||||| ||||. |  . ..  .|... |.|  . . ||.... |..|  ||||.|.|...
.....eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 933-1182 5.6e-51 168.2 In-house 43-277 (515) alignment 
Range on Protein: 933-1182
Range on HMM: 43-277/515.0
NAERSRIREVVPYEENRVEL-IPTKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSkhS
| .. | ....||. .|| | .   . .  |.|||.|. .   ..  |||.|||.. .  |||..|... |  |||||  .|| . |  .|||.  .   
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfd..ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..d

SATYGKFKVTTKfrTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeIQSVRRHTNSMlegtkNrHpPIVVHCSAGVGRTGVL
|  .|..|| .   . . |  ..  |.. | . . |||   ..|.|||.| |.. . .| .   |. |.  .. .     . | |...|||||||||||.
svkfGsikvelv..sleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllkl...ikevkadhgqy.....t.h.pliihcsaGvGrtGvv

ILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|  . ..   .  . |.|  ... .|..|....||  || |.|... . | 
isidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 911-1179 5.8e-51 168.7 In-house 2-253 (284) alignment 
Range on Protein: 911-1179
Range on HMM: 2-253/284.0
TEYEQIPKKKANGIFST-AALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMV
 |. ...|. .||   | | |..| .. || .......|.| | ..  |. . |||||.|.      .  ||||||||. |  |||.|.||. .  | ..
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq..rkdkyiatqGPldntladfWrmiweyncstivll

TaeeeggRTKSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKVKH-LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvrRHTNSml
|      . |  .|||.    .   ....|||  .  ..|  |.   ... .     . |..    .  |||.| |.    ..  .. .    || .|  
t......kdkcsqywpl....kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkv....rhlts..

egTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
   .| . .|||||||||||||| |  . ..  ......|.|  ..| ||.||  ..| ..||||.|  |..
..kenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 925-1183 2.5e-50 166.0 In-house 38-285 (290) alignment 
Range on Protein: 925-1183
Range on HMM: 38-285/290.0
FSTAALPENAERSRIREVVPYEENRVELIPTKENN---TGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHR
  ..  ..| .. | ...|.|..||. | |  ...     ||||..||      . .|||||||...|  |||...|.. | .| |.| . | |..| . 
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyk..ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

YWPKLgskHSSAtYGKFKVTTKFRTDSVCYATTGLKVKHLLS-GQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRhtnsmlegtKNRHPPIVVH
|||.     ..| ||.|...    .    | .. |.||.  | |....| ..| | |...|  .. |. |. .||..  .|         |.   .||||
YWpds...dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr.........krgntsivvH

CSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
||..|||..|..  .  |   . .  ..|  .|. .| |.. ..||  ||....|.... |..
CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0051429 (Phosphotyrosine protein) phosphatases II 959-1181 2.3e-48 160.5 In-house 3-225 (272) alignment 
Range on Protein: 959-1181
Range on HMM: 3-225/272.0
NTGYINASHIKVVVGGAEWH-YIATQGPLPHTCHDFWQMvWEQGVNVIAMVTAEEEGGRTKSHRYWP--------KLGSKHSSATYGKFKVTTKFRTDSV
 .|||||....   .   .. .....||||.|..|||.. .|.|...| ... ||| || | .||||         |.. . . .||.. ||. . .   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

CYATTGLKVKHL-LSGQERTVWHLQYTDWPDHGCPEDVqgFLSYLEEIQSvrrhtnsmlegtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVE
.|  . | ...|   |. |.|.||.|||||||| |..   .|. ||....               . |..||||||..|||....  |... ....  |.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------VPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
        .   .. ||.||. ..|| .||.|.|..|...|
dYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 909-1179 2.3e-47 156.5 In-house 26-277 (315) alignment 
Range on Protein: 909-1179
Range on HMM: 26-277/315.0
VFTEYEQIPKKKANGiFSTAALPENAERSRIREVVPYEENRVEL-IPTKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAM
.  .|| ||  .    . .|   || .. |  ....|.. ||.| .  ..... |.||. |.      . .|||.|||.. . .|||..|.|. .  | |
fkqdyesipggqlhp.ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivm

VTAEEEGGRTKSHRYWPKLgskhsSATYGKFKVTTKFRTDSVCYATTGLkvKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQsvRRHTNSMl
.|   || . |. .|||         .|||. || |       |.   |        . |.|  |.|| ||| | |.    .. .   ..  . ||||. 
ltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvk..qhhtnsv.

egtknrhPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
        .||||||||||||| .|  . ..  .| .. ..|  ... .|..|. |.|...||.|.|..|..
.......gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPRN_pd Subfamily PTPRN 911-1179 1.2e-46 153.8 In-house 33-290 (297) alignment 
Range on Protein: 911-1179
Range on HMM: 33-290/297.0
TEYEQIPKKKANGIFS-TAALPENAERSRIREVVPYEENRVELIP-TKENNTGYINASHIKVVvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMV
 |.| . . .|.   . .|  ..|... | ..|.||...||.|   ...... ||||| |       .  ||||||||..|  ||||||||||| || ..
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgplastvadfwqmvweqGvvvivnl

TAEEEGGRTKSHRYWPKLGSKHSsATYGKFKVTTKFRTDSvcYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeiqsvRRHTNSMLE
|  || | .. .||||. ||.     |    |. .  .|   |    . .| | . . |||  . .  ||..|.|   . .| .       ||  |    
trleeegvkqckrywpdeGsevy.hiyevhlvsehiwcdd..ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef.......rrkvnksyr

GtknRHPPIVVHCSAGVGRTGVLILSELMIYCLEHN-EKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
|   |  |||||||.|.||||| || .|..  | .   ....   |  ||.||  ...| .|..|.......
G...rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 927-1183 1.6e-46 153.6 In-house 41-280 (287) alignment 
Range on Protein: 927-1183
Range on HMM: 41-280/287.0
TAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKl
 .  ..| .. |..........|| |   |...  ||||..|.      . ..|....|. .|  .||...... |..| |.. |.|  . . ..|||. 
hniasqnkdknRltqilvpdnyrvll...kgehpdyinavfidgyk..ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.

gskHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLL-SGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRhtnsmlegtKNRHPPIVVHCSAGV
   ..| ..|.....   .. .  |    |.||.   .|....|   |.|.|...|  .. |  |  .||    .|         |. . .||||||..|
...eksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr.........krgntsivvhCsdtv

GRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
||.....  .  |   . .  ..|  .|.  | |.. ..||..||||........|. 
GrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 903-1181 2.5e-46 153.3 In-house 18-288 (325) alignment 
Range on Protein: 903-1181
Range on HMM: 18-288/325.0
KLEEGM-VFTEYEQIPKKKANgIFSTAALPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVGGAewHYIATQGPLPHTCHDFWQMV--W
| ..   .  |.. .| . .   . .|..||| .. | ..||.....|| |   |.. .. |||||...  ..     ..|.| ||..| .|.|..|  |
kaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd..vflaaqaPltatindlWrlvldW

EqgVNVIaMVTAEEEGGRTKSHRYWPKLGSkhSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQS
.    |. .|. | ..|  .   ||||  .   | |.| ..|  .   .   |    |.||    |. |.|  .|.  |.| | ..    ..|.|. .. 
r..csvv.vvlneldlgkdrcavywpkemg..ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

VRRHTNSmleGTKNrHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
|    ..    ||    ||.||||||||||||.|    ..  . .. .|..  ... ||..|  |..|. || ..|. |....
vservta...ntka.stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 921-1182 2.7e-46 152.7 In-house 26-278 (287) alignment 
Range on Protein: 921-1182
Range on HMM: 26-278/287.0
ANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH
.  .| .|    .... |  .|.|....|| |  . |  . |||| ..       .  .||.|||.. |  |||..|.|. . .....| | | .| | .
statfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

RYWPKLgskHSSATYGKFKVTT-KFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeIQSVRRHTNSMLEGtkNRHPPIVV
.|||.    .     | . |.  ..   .  |..  |.. .| . . | |  |.. .|||.. .    |.. .   . .|..| .   ..  .   |.||
kywPer...evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirf...vldvkqhielarda..sevGPlvv

HCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|...|.||.|.|.    ..  ||   .|.|  ..  |||.|  ..|.. |....|. |. . .
hddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0041856 (Phosphotyrosine protein) phosphatases II 933-1182 1.4e-45 150.5 In-house 1-172 (182) alignment 
Range on Protein: 933-1182
Range on HMM: 1-172/182.0
NAERSRIREVVPYEENRveliptkenNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTaeeeggrtkSHRYWPklgskhss
| .. | ....||. .|         .  ||||. .     . .  .|||||||..|. ||..|..|.|...| ..|         ...|||        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

atygkfkvttkfrtdsvcyattglkvkhllSGQERTVWHLQYTDWPDHGCPEdVQGFLSYLEEIQSvrrhtnsmlegtknRHPPIVVHCSAGVGRTGVLI
                              .  ||......|. |||||.|. .. .|...||...              .. |..|||||||||||.|.
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaGvgRtgtlv

LSELMIYClehneKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
.  ||...     .| ..  ..|.|..|. |..|  || |....| ..|.
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 960-1175 1.6e-44 147.0 In-house 2-164 (174) alignment 
Range on Protein: 960-1175
Range on HMM: 2-164/174.0
TGYINASHIKVVVGGAewHYIATQGPLPhtchdFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlgskhssatygkfkvttkfrtdsvcyattglkvk
. |||||......     ..||.||||.     ||.|..|.|.... |.. |.| |..| ..|||                                   
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

hLLSGQERTVWHLQYTDWPDHGCPEDVQgFLSYLEEIQSVRRHtnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYCLEhNEKVEVPMMLRLLREQ
 | .  ||......|. |||||.|.. . .|. ........ .         ... |..|||||||||||.|..  ||...|. .  |..  ..| || |
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlq

RMFMIQTIAQYKFVYQ
|. |.||  ||.|.|.
rpgmvqtpsQyrflyy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 932-1178 6.7e-44 144.9 In-house 2-236 (237) alignment 
Range on Protein: 932-1178
Range on HMM: 2-236/237.0
ENAERSRIREVVPYEENRVELIPTkENNTGYINASHIKVVVgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPklgSKHS
||  ..|  ..| |. .|| |  .  ... ||||...| .  |.  .|||.||||  .|.|||||||..   || |.|   || . | |.|||   | . 
enkiknrygnivaydhsrvvlkga.gsgsdyinatylkgfd.gtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp...stdq

SATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQE-RTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNsmlegtknRHPPIVVHCSAGVGRTGV
 |.||.. |. | . .   |.   | . . |. .| | ..  |.| |||.| |.    .| .  .|    .| .        .  | ..||||||||||.
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvs........esgpwiihcsagvgrtgi

LILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLI
... . |.   . .. |..   .  . |.| ..|||  || |..|...
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 929-1177 8e-44 144.6 In-house 29-262 (283) alignment 
Range on Protein: 929-1177
Range on HMM: 29-262/283.0
ALPENAERSRIREVVPYEENRVELIPTKEnntGYINASHIKVVVG-GAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLG
.  || .  | .|.||.. .|||| .  .    ||||..| |      .  ||..|.|| .|  |||.||... .  | |.|   |. | |  .|||| |
sadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

SKhssaTYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERT-VWHLQYTDWpdhgcpedvqgfLSYLEE--IQSVRRHTNSMLEGTKNRHPPIVVHCSAG
|.     ||.| || .  | |  .    | ...  | ..   . | |. ||            |.| |.  | |. .    .   |.... |||||||.|
se....dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW............leygeqaiinslvkfnkvislqteskkgPivvhCstg

VGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVL
.|||.|.|     .  .  .  |.|. ... .||||| ..||  |||.|... 
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0043147 (Phosphotyrosine protein) phosphatases II 957-1175 5.9e-42 138.7 In-house 2-155 (172) alignment 
Range on Protein: 957-1175
Range on HMM: 2-155/172.0
ENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEeeggrtkshrywpklgskhssatygkfkvttkfrtdsvcyattgl
.... |||||......    ...|||||||..|..|||.|..|.|...| ..| .                                             
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

kvKHLLSGQERTVWHLQYTDWPDHGCPeDVQGFLSYLEEIQSVR--RHtnsmlegtknrHPPIVVHCSAGVGRTGVLILSELMIyclehnEKVEVPMMLR
   .. .. ||......|. |||||.| . . .|. || |...   .            . |..|||||||||||.|..  ||.      ... .   ..
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp...........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeava

LLREQRMFMIQTIAQYKFVYQ
|.||.|. ..|.  ||.|.|.
lvrekRpgavqnpsqyrflyy
0049772 (Phosphotyrosine protein) phosphatases II 918-1182 1.9e-40 134.9 In-house 31-281 (314) alignment 
Range on Protein: 918-1182
Range on HMM: 31-281/314.0
KKKANGIFSTAALPENAERSRIREVVPYEeNRVELIPTKENNTGYINASHIKVVvggaeWHYIATQGPLPHTCHDF----------WQMV--WEQGVNVI
    .... .| |..| .. |  ...|.. ||| |     ....|||||... .       .|||||||..|..||          |.||  ... | .|
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

AM---------------------VTAEEEGGRTKSHRYWPKLGskhssatygkfkvttkfrtdsvcyattglKVKHLLSGQERTVWHLQYTDWPDHGCPe
 |                      .   ..|   . .... |                              .. .  .  ||.. .. ....||...| 
vmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.............................eelydpelferlgikylripvpDgsap.

DVQGFLSYLEEIQSVrrHtnsmlegtknRHPPIVVHCSAGVGRTGV-LILSELMIYClehneKVEVPMMLRLLREQRM-----FMIQTIAQYKFVYQVLI
. . |.. || |...  .          .. |..|||.||.||||. ...  ||...     .| .   |. .|..|.      .|..  || |....| 
lledfdeflefieea..d..........kggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefileall

QFLQ
..|.
eylk
0046846 (Phosphotyrosine protein) phosphatases II 956-1182 1.4e-39 131.0 In-house 8-174 (176) alignment 
Range on Protein: 956-1182
Range on HMM: 8-174/176.0
KENNTGYINAShikVVVGGaewHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSsatygkfkvttkfrtdsvcyattg
 ...  ||||.   ...|.   ..||||||||.|. ||..|..|.|.... ..| | | || | ..||| | . .                         
ldldldyinan...lilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lkvkhllsgqertvwHLQYTDWPDHGCPEDvQGFLSYLEEIQSVRrhtnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYclehNEKVEVPMMLRL
               . ....|||||.|.. . .|. ||.|....           ... |..||||||.||||.|..  |...    .  . |   |.|
...............qylhlpwpDhgvpdl.elllellefireal...........keggpvlVHCsaGigRtgtlvaayllel....ekglsveealal

LREQRM-FMIQTIAQYKFVYQVLIQFLQ
.||||. ...|| .||.|.|... ..|.
vreqRplgavqtpeQyrflyefellllk
subfamily_CG7180_pd Subfamily CG7180 922-1180 1.5e-38 127.1 In-house 31-289 (296) alignment 
Range on Protein: 922-1180
Range on HMM: 31-289/296.0
NGIFSTAALPENAERSRIREVVPYEENRVELIPTK-ENNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRtKSH
.|   ..   || |. |  .||||. ||| |   . |... ||||...   .  .|  || |..|  .| ..||..|...... . ..| . .  . . .
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

RYWPKLGskhsSATYGKFKVTTKFRTDSVCYATTGLKVKHL----------LSGQERTVWHLQYTDWPD-HGCPEDVQGFLSYLEEIQSVRRHTnsmleG
 |||. .     . ||.. | .          .  .|...            . ..|.| ..|.| |.  . .|   ....  .. ....|...      
sywpnks....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.....d

TKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF
 .. . |.||..| |..|.|| .  .  .  .|..|.|.|  ... ||..|  ..... .||..|.|| ..
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0049260 (Phosphotyrosine protein) phosphatases II 978-1175 3.3e-38 126.1 In-house 10-144 (152) alignment 
Range on Protein: 978-1175
Range on HMM: 10-144/152.0
HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWpklgskhssatygkfkvttkfrtdsvcyattglkvkhllsgqertvwHLQYTDW
..||||||.|.|. |||.|..|.|...| |.| ..| |. | ..|.                                               . ... |
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpw

PDHGCPEDVQGFLSYLEEIQSVRRHTNSmlegtknrhpPIVVHCSAGVGRTGVLILSELMIyclehnEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQ
||||.|.. | .|  |. |.  ... .           |..|||||||||||.|..  ||.       .|..   ..|.||.|. ....  |..|.|.
pDhgvpdlsqlllflllfieklaldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 895-1179 6.2e-38 125.4 In-house 9-277 (439) alignment 
Range on Protein: 895-1179
Range on HMM: 9-277/439.0
ERFRTLKKKLEEgMVFTEYEQIPKKKAN--GIFSTAALPENAERSRIREVVPYEENRVEL--IPTKEnNTGYINASHIKVVVggAEWHYIATQGPLPHTC
|    |.|. .| ..  ..|.|   . .   | | ||   .  . | ..|....  || |  ||     . |||| .||      .  |||||||  .|.
ehvekldknkqe.ifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp.hshyinanyikGyy..ddklyiatqgpkkett

HDFWQMVWEQGVNVIAMVTAEEEggrtkSHRYWPKlgskHSSATYGKFKVTTKFRTDSVCYATTGLKV--KHLLSGQERTVWHLQYTDWPDHGCPEDVQG
.|||..|.|. .  | |.|   |     |..|||      . . ||   | .    .   |.  |.||  ..  . .|||| ...|. |||.  | .   
ddfwrlviekktvtivmltnlve.....sykywps....daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

FLSYLEEIQSVrrhtNsmlegTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
 | .|  |.|     |      |.   |.|||||||||||| .|  .. .  |  ..||..  ....||.||  |.|...|| |.|. ...
vldflrainsa....n.....dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 902-1179 1.4e-37 124.0 In-house 15-234 (392) alignment 
Range on Protein: 902-1179
Range on HMM: 15-234/392.0
KKLEEGMVFTEYEQIPKKKANGIfSTAALPENAERSRIREVVPYEENRVEL-IPTKENNTGYINASHIKVVvgGAEWHYIATQGPLPHTCHDFWQMVWEQ
|.    ..| |. ..|  ..    ..|  . | .. | ....||...|| | .    ... |.|||.|. .   .|  |||.||| . . .|||.||...
knrhsalffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf..dnekayiasqgpnaaslddfwrmvfqe

GVNVIAMVTAEEEGGrtkshrywpklgskhssatygkfkvttkfrtdsvcyattglkvkhllSG-QERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSv
 |  |||||  .||                                                 | . |||   ..|.|||.. |. .  .| ...|... 
nvttiamvtklkegd...............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.

rRHtnsmleGtKNRHpPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
  .      | .  | |...|||||||||||.|  . ..   ..   |.|  ..  .|..| .|.||  || |.|  ...
.df......G.qyth.pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 909-1181 3.3e-37 123.1 In-house 18-277 (307) alignment 
Range on Protein: 909-1181
Range on HMM: 18-277/307.0
VFTEYEQIPKKKANGIfSTAALPENAERSRIREVVPYEENRVeLIPTKENNTGYINASHIKVVVGgaEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMV
.  |.... ||. .|. .. |.  |... | ..|   . .|. .. ..   . || | .. . .     ..|..||||  | ..|| |. .. |. . |.
lvdefrvlakktpegv.tveafsantdknryqdvkcqdkgri.vvkfdglasdyihanylgiaik..pkkficaqgplentqysfwamaiqekvesviml

TAEEEGGRTKSHRYWPKLGSKH-SSATYGKF-----KVTTKFRTDSVCYATTGLKVKHllSGQERTVWHLQYTDWPDHGCPEDVqgfLSYLEEIQSVRRH
    | .. | ..|||    ..   .  ..        . |.  |  .   | |||.   ... ||. |||...|||.|.|.     |. .. ...|| .
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqin...ltainlleavryd

TNsmlegtknrhpPIVVHCSAGVGRTGVLI-LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
||           |.||||||||||.| .. .| ..   ..  .  ..  ... ||.|| . ||| ||| ....||....
tn...........pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 928-1182 2.6e-36 119.9 In-house 35-294 (301) alignment 
Range on Protein: 928-1182
Range on HMM: 35-294/301.0
AALPENAERSRIREVVPYEENRVELIPTKE---NNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP
    ||.. .| .....|..||. | |...    .. |||||.|. .    . ..||.|||. .|  |||...|.. .  | ||| ..|| ..|...|||
glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywp

KlgSKHSSATYGKFKVTTKFRT---------------DSV--CYATTGLKVKHLLsgQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvRRHTNsml
.  |...| ..|.|.|| .  .               |.    |    .|||.    . ..|  || ||||..|   . .  |  ....      ..   
n..seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddv...ihrqq...

egtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
   |    |.|||||..|.|.|| .  .. .     .  |.|  . . .| ... ...|. || ..|.|. ..||
...kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 934-1176 3e-35 116.5 In-house 8-235 (239) alignment 
Range on Protein: 934-1176
Range on HMM: 8-235/239.0
AERSRIREVVPYEENRVELIPT-KENNTGYINASHIKVVVgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKhss
  . |  ..| |. .|| |    ..  . |||||...    |.   |||||| .  .. |||.|.|..   || |.|   || . | |.|||   ||   
kaknryanivtydhsrvvleklsndphsdyinasylrdyd.gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...

atYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeiqsVRRHTNSMLEGTKnrhpPIVVHCSAGVGRTGVLI
  | ...|| .       |    . . ..   .|| |.. ..| |||.| |.     |         |. |.  | |..    | |.|||||||||| ..
..ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl......rrkitkdslpgar....pwvihcsagvgrtgafl

LSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQV
. . |.   .... |..   .. .||.| .|.||  || |..  
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 933-1176 3.1e-35 116.5 In-house 8-236 (239) alignment 
Range on Protein: 933-1176
Range on HMM: 8-236/239.0
NAERSRIREVVPYEENRVELIPT-KENNTGYINASHIKVVVgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKhs
|  . |  ..| |. .|| |    ..  . |||||...    |.   |||||| .  .. |||.|.|..   || |.|   || . | |.|||   ||  
nkaknryanivtydhsrvvleklsndphsdyinasylrdyd.gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..

satYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYleeiqsVRRHTNSMLEGTKnrhpPIVVHCSAGVGRTGVL
   | ...|| .       |    . . ..   .|| |.. ..| |||.| |.     |         |. |.  | |..    | |.|||||||||| .
...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlgl......rrkitkdslpgar....pwvihcsagvgrtgaf

ILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQV
.. . |.   .... |..   .. .||.| .|.||  || |..  
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_ptpA1_pd Subfamily ptpA1 932-1145 8.6e-34 112.0 In-house 46-260 (418) alignment 
Range on Protein: 932-1145
Range on HMM: 46-260/418.0
ENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKvvvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKH
 |. . |  ...| .  ||.|   ...  . |||| .|    |    ..|.|||||| |  |||.||||. . .| |.. | |  | |  ||||.     
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid...gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

SSATYGKF-KVTTKFRTDSVCY------ATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvRRHTNSMLEgTKNRHPPIVVHCSA
  . ||.  .|   .  . |             ...  . |. | . . ||  ||||  |.  | |   |  |     . | ..  . .|  ||.|||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsi...tnrqnqiip.ssdrnvpiivhcsa

GVGRTGVLILSELMIYCLEHNE
|||||| .  . .|.  |.|  
gvgrtgtfctavimmkkldhyf
0044763 (Phosphotyrosine protein) phosphatases II 944-1184 1.5e-33 111.3 In-house 1-174 (178) alignment 
Range on Protein: 944-1184
Range on HMM: 1-174/178.0
PYEENRVELIPTKENNTG-YINASHIKvvvggaEWHYIATQGPlphtcHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSkhssatygkfkvtt
|....|| |..    ... |||||.|       .  |.....|      |......|.|...| ..| | |.|. |...|||.  .              
pldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

kfrtdsvcyattglkvkhllsgqertvWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRrhtnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIYCle
                           .. ... .||||.|.  . ||  .| |....          .... |..|||||||||.|.|..  ||...  
...........................iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaaylmkkl..

hneKVEVPMMLRLLREQRMfMIQTIAQYKFVYQVLIQFLQNS
   .. ..  ..|.||.|. ....  |....|..  ..|..|
...glsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
PTPc_DSPc_SM00012 1068-1178 5.8e-33 108.6 In-house 1-104 (105) alignment 
Range on Protein: 1068-1178
Range on HMM: 1-104/105.0
TVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSmlegtknrHPPIVVHCSAGVGRTGVLILSELMIYCLEHN-EKVEVPMMLRLLREQRMFMIQT
|| |..||.|||||.||... .|..|......... .|        ..|.||||||||||||.... ....  ||.. ..|.. .... ||.||. |.||
tvkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt

IAQYKFVYQVLI
 .|| |.|..|.
eeqylflyrall
0051082 (Phosphotyrosine protein) phosphatases II 960-1177 7.4e-33 108.6 In-house 3-149 (151) alignment 
Range on Protein: 960-1177
Range on HMM: 3-149/151.0
TGYINASHIKvvvGGaewhYIATQGPLPhtchDFWQMVWEQGVNVIAMVTAEEEGGrtKSHRYWPKLGskhssatygkfkvttkfrtdsvcyattglkvk
..|||.| .    ||    .....|||.    ||.....|.|...| ... ||| |  . ..|.|.||                                
sdyinfsyvt...gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

hllsgqeRTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSvrrhtnsmlegtkNRHPPIVVHCSAGVGRTGVLILSELMIYClehnekVEVPMMLRLLREQ
       ..|.|....||||.|.|.  . .|..||....             ... |..||||||.||||.|..  ||..       | .   |. .|..
.......ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlk

RMFMIQTIAQYKFVYQVL
|. ..|.  |. |....|
rpgvvqpnqqflfqlfal
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 932-1186 2e-32 107.1 In-house 47-292 (305) alignment 
Range on Protein: 932-1186
Range on HMM: 47-292/305.0
ENAERSRIREVVPYEENRVELIPTKenNTGYINASHIKVvvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHS
..|.. | ..|   ..||| | ..      || | ..          .| || || .|| ||| | ... |. | |.    | |  | . |..    .  
qeagknrykdvgcldnnrvklegpw..pheyihanyvst..ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

SATYGKFKVTTKFR--------TDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSyleeiqsvrrhtnsMLEGTKNRHPPIVVHCSA
.   .  |.. ||         .|.    |    |     .. | | |  . |||| | |   .  |               .|| ..  . ||||||||
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile..............llekarpskgpivvhcsa

GVGRTGVLILSELMIYCLEHNEKVE-VPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRL
|.|||| ... | ..  |   ...|    .|. .||||   ||| ||| ||.||....... .|
gigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 936-1181 7.2e-32 105.2 In-house 58-289 (305) alignment 
Range on Protein: 936-1181
Range on HMM: 58-289/305.0
RSRIREVVPYEENRVELipTKENNTGYINASHIKVVVGgAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKL-GSKHsSAT
. | ..|   ... | |   | . . || | .. . .   |  .|..|||| .|  .|| || .. |. | |.    | |. |  .|||   | |. .  
knryqdvpcqdqsavkl..dkpspsdyihanyvgcpmi.pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl.elk

YG---KFKVTTKFRTDSVCYATTGLKVKHlLSGQERTVWHLQYTDWPDHGCPEdvqGFLSYLEEIQSVRrhtnsmleGTKNrhpPIVVHCSAGVGRTGVL
 |   .    .|          | |.. .   .|. .| |||.|.||| | |      |. || . ..|        |.|    |||||||||.|||| .
sgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvpp...ckltslellsair........gskv...pivvhcsagigrtgti

ILSELMIYCLEHNEKV-EVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
.  | ..  .  | ..  .| ... ||.|| | ||.  || |...|.....
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 933-1181 4e-31 102.7 In-house 54-283 (290) alignment 
Range on Protein: 933-1181
Range on HMM: 54-283/290.0
NA--ERSRIREVVPYEENRVELipTKENNTGYINASHIKvvvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlgSKH
|.  .. | ..||  .  || |      .  |. | ..|    | .  .| |||.|  |  |.|.|| ...| .| |.    | |..| ..|.|.   . 
ntefkknrykdvvcndktrvil..kdGydGdyvhanyvk....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype..keG

SSATYGKFKVTTKFRTDSVCY-ATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVqgfLSYLEEIQSVRRHTnsmleGtknrhpPIVVHCSAGVGRTG
   |.|.. |.    .|         | |..  ||.|  . ||.   |||.  .      |. |  ....|. .     |      |.|||||||.||||
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilrkas.....G......pvvvhcsaGiGrtG

VLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
 ..  |  . .| .  ....  . | ||. |.  .|   ||  . ..|... 
tfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 928-1181 4.2e-31 103.0 In-house 38-271 (288) alignment 
Range on Protein: 928-1181
Range on HMM: 38-271/288.0
AALPENAERSRIREVVPYEENRVELIptkENNTGYINAsHIKVvVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlg
 .  .|. | | ...   .  || |    ..   ||.| ..    .  . . | .| ||  |   .|.|. |..|. | |..   | |. ||  |.|   
dsfianptrdryenlprcditrvkls...ddpdfyiaa.nvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs..

SKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERT-VWHLQYTDWPDHGCPEDvqgFLSYLEEIQSVrrhtnsmlegtKNRHPPIVVHCSAGVG
 .  .| .|..   .| . . .    .   ..    |.|.  | .| . .|.|.| ||.   .||.|  .. .           |. . |||||.|||||
klGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrllevl...........kslqkPivvhssaGvG

RTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
||| |||. ...  |  .. . .. .|  |||.|.  |||  || .|.... . |
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 925-1182 2.4e-29 97.1 In-house 25-260 (267) alignment 
Range on Protein: 925-1182
Range on HMM: 25-260/267.0
FSTAALPENAERSRIREVVPYEENRVELiPTKENNtgYINASHIKVVVGGAewHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKShrYWP
 |.    .|.|| |. ...||...|| |  |||..  |||||...    .   ..|.||.||  |  ||.... .|.| || ..|   ..   .   . |
isqsiaeknqernrlddnlpyddtrvil.rtkeee..yinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPP

KLGSkhsSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSgQERTVWHLQYTDWPDHgcpEDVQGFLSYLEEIQSvrrHtNSmLEgtkNRHPPIVVHCSAG
|.|    .  |  . |   .  .   |    |..|       . |    |  |       . . .|  |  | .   . |  ||   |  .|.||.||.|
kmgq...akkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnin...tnnkpylkplfgila...k.nq.le...ngnrPlvvacsdG

VGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
|||.| ..  . ..  . ... ...  .|| .|.||. ...|  .| .....| .. .
vGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 947-1172 8.8e-29 95.2 In-house 64-272 (301) alignment 
Range on Protein: 947-1172
Range on HMM: 64-272/301.0
ENRVELIptKENNTGYINASHIKVVvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSkhSSATYGKFKVTTKFRT
.  ||.|  .. .   | |  |.    |   ..|||||||. |..||| |.    |. |.|.. . |   .| . | |   |  ..   |.||...| . 
stavevi..vdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknke

DSVCYATT--GLKVKHLLS-GQERTVWHLQYTDWPDHGCPEdvqgflSYLEeiqsvrrhTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEH
  .   ..   |.|.      . ||| | ||..|.|.| |.      |. |        .  ..|  |. . |||||||||.||.  .| .| .   .| 
lilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk......shae........lfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

NEKVEVPMMLRLLREQRMFMIQTIAQYKF
. ..|.   |. |||.|   .||  |  .
dptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 913-1181 1e-28 94.8 In-house 33-290 (310) alignment 
Range on Protein: 913-1181
Range on HMM: 33-290/310.0
YEQIPKKKANGiFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEE
| ..  |. .  ..  |  ..  . |  .||  .. || |   |     || | ..|         .| .|||| ||  |||.|....  . | ..    
yrkldakqdss.ltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvg

EGGRTKSHRYWPKLGSkhsSATYGKFKVTTkFRTDSVCYAT---------TGLKVKHLL-SGQERTVWHLQYTDWPDHGCPEdvqgflsylEEIQSVRRH
| || |.  ||| ||    . |||  .||  .   |  .             . |       .|  |  ... .||| | |.         |  ..| . 
eegrpkcvgywpslgv...tetygcirvtn.lsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.........ekchtvpqr

tnsMLegTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
   .|  .. || | |||||||..|..|..  .| |  |.. .||..  .   |. .|.  |||  || .. .| | | 
...ll..aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 959-1184 5.4e-28 92.6 In-house 66-279 (312) alignment 
Range on Protein: 959-1184
Range on HMM: 66-279/312.0
NTGYINASHIKVVVGGAewHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSK---HSSATYGKFKVTTKFRTDSVCYA-TT
.  || |  .|..      ....|||||  ||  |||..   |   | ....  | |  |. .|   . .         | ..    .    |       
enfyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr

GLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLsyleeiqsvrRhtnsMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLR
 |||    .|||  . | |.. ||||| |. ..  |          |    .|   |. . |.. |||||||||| |.| | || .| |  | .|  .. 
vlkvvvkatgqesklnhyqwaswpdhgmpdscdtal..........r....llsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfv

LLREQRMFMIQTIAQYKFVYQVLIQFLQNS
||| .|   .....|| .. .....|| . 
llrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 929-1181 1e-27 91.9 In-house 31-270 (285) alignment 
Range on Protein: 929-1181
Range on HMM: 31-270/285.0
ALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVvVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP-KLG
|   | .  |  .|   || || |   |. .  || || ...  |  .  ||.|||||| |  |||.|.... .  . |. .  |||  |   |.| |||
ayeanpdlnryadvrcieetrvvl...knhdrdyihaswmrm.pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

SkhsSATYGKFKVTT-KFRTDSVCYA-TTGLKVKHL--LSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVrrhtNsmlegtkNRHPPIVVHCSA
       .||...|  . . .... .    | |      | .   . |.|   |||. .||| . ..   . .. |    |        .  ||.|||||
e...vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv....n.......pkekpicvhcsa

GVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFL
|||||  ..  .     .  | ..|.  ..| .|  |.  .|.  |. |.| ||....
gvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_CG42327_pd Subfamily CG42327 909-1099 1.1e-27 91.5 In-house 7-193 (319) alignment 
Range on Protein: 909-1099
Range on HMM: 7-193/319.0
VFTEYEQIPkkkaNGIFSTAALPEN-AERSRIREVVPYEENRVELIPT-KENNTGYINASHIKVVvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIA
|. |....|    . | .. ..|    ..||. .|||  | || |    ..... |..||...     |. .|||.| .|  .  |||..||||   || 
vaeefrdlP....qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGy.ddapnsyiaaqvsledsssdfwrtvweqqsrviv

MVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYtDWPDHGCPEDVQGFLSYLEEIQSV
 .|   | |  .  .|.|   .  .  .||...|| | |     ||.. | .|..   . | . |  | .|.. . | . . ... | |..| 
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 912-1180 5.7e-27 89.1 In-house 16-268 (281) alignment 
Range on Protein: 912-1180
Range on HMM: 16-268/281.0
EYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIP--TKENNTGYINASHIKVVVggAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVT
|. ..|      . ..   | | .. |  ..   .  ||.|     ..| | || | .|.  .   .  || ||||   |  |||.|.|..    | |. 
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkketradfwrmiwqenttaivmlc

AEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHllSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSvrrhtnsmleg
   |  | |   |.|.    |    . |. |. .  |      || |.. .   |. | . |  . .|||   ||  . .|  | .|..           
qfletnrekcaeyfpr..nahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkira...........

tknRHPPIVVHCSAGVGRTGVLILSELMIYCLE-HNEKVEVPMMLRLLR-EQRMFMIQTIAQYKFVYQVLIQF
   |  | |.||||||||.| |.  |. .  .  |    ..  ..  ||   |   .||. || ....||..|
...rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
FERM_M FERM central domain 109-220 6.4e-26 81.2 Pfam-A 5-126 (126) alignment 
Range on Protein: 109-220
Range on HMM: 5-126/126.0
LQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYN-QFDSQD-F-LRE--YV----LFP-MDLALEEAVLEELTQKVAQEHKAHSGILP
...|......|.|.|.|.||.|| || .....||.|..|...||.. ......   . |  .     |.|     |..   ..|.|.....|| ..|. .
kydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvaglsl

AEAELMYINEVERLDGFGQEIF
|||.|.|......| ..| . |
aeaklkylqaaqslpdyGvslF
0048076 (Phosphotyrosine protein) phosphatases II 1050-1179 8.4e-26 85.8 In-house 28-141 (145) alignment 
Range on Protein: 1050-1179
Range on HMM: 28-141/145.0
CYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHtnsmlegtknrHPPIVVHCSAGVGRTGVLILSELMIYclehnEKVEV
   || | . . |.. ||......|..|||||.|.. . .|. || |......           . |..|||||||||||.|..  ||..     ..| .
lgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

PMMLRLLREQRMFMIQTIAQYKFVYQVLIQ
.  |.|.|.||......  |..|.|... .
eealelvrsqrpgavpnpgqlrflyefele
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 978-1176 2.8e-25 83.6 In-house 5-198 (198) alignment 
Range on Protein: 978-1176
Range on HMM: 5-198/198.0
HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSkhSSATYGKFKVTTKFRTDSVCYATTGLKVKHL--LSGQERTVWHLQYT
.||||| || .|  |||||||| |   | ||  ..    .    |||   |  ... || . ||||  |    |. | | .          | . | |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPDHGCPeDVQGFLSYLEEIQSVRRHtnsmLEgtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK--VEVPMMLRLLREQRMFMIQTIAQYKFV
 | ..  | .|  |. ..   . | ..     |  ...  |..|||| | | |||..  .. .   |      |..  . . ||. |  .| .. .|.|.
swkekttp.nvalfvgfvvasrevskk....ye..qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQV
|||
yqv
subfamily_eak_pd Subfamily eak 928-1183 3e-25 83.3 In-house 47-307 (332) alignment 
Range on Protein: 928-1183
Range on HMM: 47-307/332.0
AALPENAERSrIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGaeWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLG
.|  |. .|  . ..|||. . |.| ... |. |||||| ..    |   .|| |  .       ||||| ||    | ..  . | .  || .|.|. .
tarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevG..rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt

SKhsSATYGKFKVTTKFRTDSVCYATTGLKVKHllsGQE-RTVWHLQYTDWPDHGCPEdVQGFLSYLEEIQSV-----RRHTNSMLEGTKNR--H-PPI-
 .     .|...|..|       . |  |...    | |   | | ..  | .   |  .. ||.. . .. |         ...|. | ..  | ||  
re..elkfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpk.yedflalrkvmkevGvlllivmksallsstlkkyihtppsf

--VVHCSAGVGRTGVLILSELMIYCLEHNEKV--EVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
  .. .. |  |.||... .|.|  .. . |    |  ..   ...|.  . .  |. |.|......|..
apiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 978-1176 3.1e-25 83.5 In-house 6-199 (199) alignment 
Range on Protein: 978-1176
Range on HMM: 6-199/199.0
HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSkhSSATYGKFKVTTKFRTDSVCYATTGLKVKHL--LSGQERTVWHLQYT
.||||| || .|  |||||||| |   | ||  ..    .    |||   |  ... || . ||||  |    |. | | .          | . | |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPDHGCPeDVQGFLSYLEEIQSVRRHtnsmLEgtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK--VEVPMMLRLLREQRMFMIQTIAQYKFV
 | ..  | .|  |. ..   . | ..     |  ...  |..|||| | | |||..  .. .   |      |..  . . ||. |  .| .. .|.|.
swkekttp.nvalfvgfvvasrevskk....ye..qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQV
|||
yqv
subfamily_egg_pd Subfamily egg 925-1182 2.7e-23 77.1 In-house 32-271 (307) alignment 
Range on Protein: 925-1182
Range on HMM: 32-271/307.0
FSTAALPENAERSRIREVVPYEENRVELI-PTKENNTGYINASHIKvvvGGAE-WHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGgrTKSHRY
. |||  .| |..| . |   .  ||.|  .       .| | ..|   |.    ..| .| ||  | .|||.||... |. | |.|.  |    . . |
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk...Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPKLGSKHSSATYGKFKVTTkFRTDSVC---YATTGLKVkhllSGQErtvwhlqytdwPDHGCPEDVQGFLSYLEEIQSVRRhtnsMLEGTKNRHPPIVV
|||  |.      | ..... .. ||     .  | ||.     | .            .    |  || . .. .. |  |    .|   .|   |.||
wpkaesdslvtvpGslrien.lkvdskadplfrvtklkl....vGgd...........deerflehwqgdvnnssdvysplr....vlrklrnlskpvvv

HCSAGVGRTGVLILSELMIYCLEH--NEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQ
..  || ....|.  |. .  |      |  |     .|| .| . .... .| |||.... |..
qdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
FERM_N FERM N-terminal domain 25-103 4.4e-23 71.4 Pfam-A 1-80 (80) alignment 
Range on Protein: 25-103
Range on HMM: 1-80/80.0
IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWF-LSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYV
.||||..| |.|.. ..||...||.|..||.|.||.||||.|   |... .|....| |......  .. .|.. | |||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfyv
0048179 (Phosphotyrosine protein) phosphatases II 1063-1175 1e-22 75.9 In-house 43-139 (144) alignment 
Range on Protein: 1063-1175
Range on HMM: 43-139/144.0
SGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVrrhtnsmlegtKNRHPPIVVHCSAGVGRTGVLILSELMIyclehNEKVEVPMMLRLLREQRMF
   ||.........|||||.|.. . .|. || |...            ... |..|||||||||||.|..  ||.      ... .   |.|.|..|..
efleregiqylhlpwpDhgvpdllellleflefieea...........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg

MIQTIAQYKFVYQ
....  |..|...
avpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 934-1029 2.4e-22 74.2 In-house 48-156 (350) alignment 
Range on Protein: 934-1029
Range on HMM: 48-156/350.0
AERSRIREVVPYEENRVELI----PTK-----ENNTGYINASHIKVVVGG----AEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH
  . | ....||| .||.|     ...      .   ||||...|. . .    ....|||||.||| | .||.... . .|.|| ..|.. | .. | .
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPKLGSK
|||.... .
rYWqegsyd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 928-1180 1.5e-19 64.7 In-house 42-278 (303) alignment 
Range on Protein: 928-1180
Range on HMM: 42-278/303.0
AALPENAERSRIREVVPYEENRVELiptkeNNTGYINASHIKVvvgGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLG
  . .| .. |. .|.  .  .|.|      .. || ||....    .. . | || ||.||. |||||. || |... .. .. |  .   .  .|.  
nqfvknmdknrfvdvicldhskvkl.....sdssyihasylel...dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

SkhSSATYGKFKVTTKFRTDSVCyATTGLKVKHLLSGQERTVWHL-QYTDWPDHGCPED-VQGFLSYLEEIQSVRRHTnsmlegtKNRHPPIVVHCSaGV
         ..    .|.   .      |||  .  |. ..  |. .| .||    | |    |.  . ..||| |.         . .|.. .  | |.
d..flkfeersirvgefkrvelg.dgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky.......sdstptvymsls.gc

GRTGVLILSELMIYCLeHNEKVEVPM--MLRLLREQRMFMIQTIAQYKFVYQVLIQF
||.| . | |     | |.|.  . .   |  .|. |.  .| ..|. .|| .| . 
gragtfalfetahlsl.hseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 900-1183 2.6e-19 63.7 In-house 19-287 (302) alignment 
Range on Protein: 900-1183
Range on HMM: 19-287/302.0
LKKKLEEGMVFTEYEQIPKKKANgIFSTAALPENAERSRIREVVPYEENRVELiptKENNTGYINASHIKVVVGGaeWHYIATQGPLPHTC---HDFWQM
| |.|... | .|...| . |.. . .  |  .| ....  .|  ...|.| |   ....  |.|||...|   .     | .| |   .     .||.|
lvksldtaevkkefkkidtmkvd.lekCkafkknlkknqsedvpildsnlvkl...eaepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrm

VWEQGVNVIAMVTAEEEGGRtKSHRYWPKLGSKHSsaTYGKFKVTTKFrTDSVCYATTGLKVKHLLSGQERTVWHL--QYTDWPDHGCPEDVQgflSYLE
|... .  . ..  |||  .   . ..||.  ...  .|||. | ..   ...  ..| . .  |  |   .|       | |...  |. .    .  .
vfqekivsvvilvgeeelkk.tlselfpkksgdyk..eygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya...elik

EIQSVrrhtnsmLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQN
....|        . . .   ..|.    |.|| |...   . . .|........  ... .|.||  ..... || ..| .|. ....
taakv.......fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_CG42327_pd Subfamily CG42327 1106-1180 2.2e-18 61.0 In-house 239-314 (319) alignment 
Range on Protein: 1106-1180
Range on HMM: 239-314/319.0
MLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHN-EKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF
   ||.... |.||||| ||||||..| |.. |  ||.. . |..| ..  .|..|   ..|. ||.|.|.|| ..
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1068-1180 4.3e-18 60.2 In-house 216-343 (350) alignment 
Range on Protein: 1068-1180
Range on HMM: 216-343/350.0
TVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLI-----LSE--LMIYCLEHNEKVEVPMMLR------
 |..||.  |.| .   . . .|. ||  . .    .. .   ..| .||.|||||||||||.|.     ||.   .    .. .|..|. ..|      
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

--LLREQRMFMIQTIAQYKFVYQVLIQF
   ||.||. |.|.. |. |.|. |  .
vnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1068-1181 2e-15 51.0 In-house 219-344 (349) alignment 
Range on Protein: 1068-1181
Range on HMM: 219-344/349.0
TVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIY----CLEHNEKVEVPMML--------RL
 .. ||. .|.| .   . . .|  ||  . .    .. |   ... ....|||||| ||||||.  .|..       ..  |.... .|          
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LREQRMFMIQTIAQYKFVYQVLIQFL
|| ||. |.| .||. ..|. |....
lrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 989-1181 1.2e-14 49.0 In-house 40-221 (255) alignment 
Range on Protein: 989-1181
Range on HMM: 40-221/255.0
TCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVqg
|   |.|..  .. .|..|..  .| |. | ..|.|    |     . . .|||   .  |   |  .  .     . .|| | .|. |...  ||.   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl..ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPela..

flsylEEIQSVRRHTnsmlegtKNRhPPIVVHCSAGVGRTGVLILSEL----MIYCLEHNEKVEVPM--MLRLLREQRMFMIQTIAQYKFVYQVLIQFL
     .||. . .         ..   ..|||||.|.||.  ..| ||    ||  |.  | ||.    .|. ||..|   |.|  |  |   ......
.....reilnilkvv.......rds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 920-1025 8.6e-14 45.7 In-house 83-180 (244) alignment 
Range on Protein: 920-1025
Range on HMM: 83-180/244.0
KANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTgYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEggrtkS
    ..  |  |.|. ..|    .|.. ||| |      || ||||| .  .   ||  || || ||  |  |||.|. |. |||. .. . ||      
pdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgnt.yinasfvgclgrtae..yiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....e

HRYWPK
  ||| 
deywpd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1065-1180 4.4e-13 43.3 In-house 87-193 (440) alignment 
Range on Protein: 1065-1180
Range on HMM: 87-193/440.0
QERTVWHLQYTDWPDHGCPEDVQGFlsyLEEIQSVRRHTnsmlEgtKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMI
. ||. . .|  |||.| |. .      |. || |        |  |    |..||||||.|||||.|  . ..   ........  ..  .|..|  |.
esrtlkqyhyqgwpdkgvpkfagpv...lkmiqdvnesq....e..kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmv

QTIAQYKFVYQVLIQF
||  || ||...... 
qtpeqyafvheavleg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 960-1026 6e-13 42.8 In-house 90-156 (349) alignment 
Range on Protein: 960-1026
Range on HMM: 90-156/349.0
TGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKL
  |||| ..|.    .| .||||| ||| | .||....  .||...  .. ..| .  | ..|| .|
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 946-1178 8.5e-13 43.1 In-house 31-256 (290) alignment 
Range on Protein: 946-1178
Range on HMM: 31-256/290.0
EENRVELIPT-KENNTGYINASHIKVVVGgaeWHYIATQGPLPHT-------CHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH----RYWPKlgSKHSSA
|..|| |    |  | .|| |.....  |    . |.|| |. ..         .|| |. .  |. . |.   ||  . .|.    .| |.  |   . 
eatrvvLkgygkrfnddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe..svgeel

TYGKFKVTTKFRTDSVCYATTGLKVKHlLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIqsvrrhtnsmlegtKNRHPPIVVHCSAGVGRTGVLIL
... ..|  | .       |  | ||.   ..| || | .. .| .   .|| . .|| .. .              |... |..|||  |. |  .|  
kfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkv..............kasktpvivHcvdGiSrsAalaa

SELMIYCLE-HNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLI
..|    .   ...|..  .|  ||.||  .|..  .. ||  ...
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 985-1173 8.5e-13 42.4 In-house 99-280 (302) alignment 
Range on Protein: 985-1173
Range on HMM: 99-280/302.0
PLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWP-KLGSKHssaTYGKFKVTT-----KFR--TDS--VCYATTGLKVKHLLSGQERTVWHLQY
|   |.  .| .. .  | ... ...  |..  |   |.  |.| .    ..|.. |.|     ..   ||   .   |  .| ..  . ...||  |..
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggel...kfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TDWPDHGCPEDVQGFLSYLEEIQSVRRhtNsmlegtknrhppIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFV
. ||||| |.. .  |  |   .| ..  |            ..||||||||||| |.     |    ...  ..  ..  .|. |   .|.  |  ..
sawpdhGapkeaytaldilkfcesykk..n............vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 988-1183 3e-10 34.5 In-house 45-229 (263) alignment 
Range on Protein: 988-1183
Range on HMM: 45-229/263.0
HTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKlgSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQ
 | . |.|..  .. .|..|..  .| |. |  .|.|    |     . . .|.|    . |   |  |        . .|| | .|. |...  ||. .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPl..ekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

GFLSyleeIQSVRRHTNsmlegtknrhpPIVVHCSAGVGRTGVLILSEL----MIYCLEHNEKVEVPM--MLRLLREQRMFMIQTIAQYKFVYQVLIQFL
  |     |  | |.             ..|||||.|.||.    . ||    ||  |.  . ||.    .|. ||..|   |.|  |  |   ....|.
eiln....ilkvarnsk...........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

QN
 |
ln
FERM_C FERM C-terminal PH-like domain 224-306 4.7e-10 29.9 Pfam-A 1-86 (90) alignment 
Range on Protein: 224-306
Range on HMM: 1-86/90.0
DNHGNCVHLGIFFMGIFVRNRIGRQ-AVIYRWNDMGNITHNKSTILVELIN--KEETALFHTDDIENAKYISRLFATRHKFYKQNK
...|. ..||.   |. . .   .     ..|... ...... .....| .  |...  |.... ...|.. .|    |.......
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrrrr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 951-1005 8.1e-10 32.7 In-house 55-113 (347) alignment 
Range on Protein: 951-1005
Range on HMM: 55-113/347.0
ELIPTK------ENNTGYINASHIKVvvGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVI
 | | |      ..  .||||||||     |. .|| || |||.|  |||.||    |  .
vlspeksknsraddvetyinashikf..dnaskeyiltqyplpdtvrdfwkmvsvtkvtqv
0038934 (Phosphotyrosine protein) phosphatases II 1073-1174 5.2e-09 31.5 In-house 81-170 (194) alignment 
Range on Protein: 1073-1174
Range on HMM: 81-170/194.0
QYTD--WPDHGCPEDVQGFLSYLEEIQSVRrhtnsmlegTKNRHPPIVVHCSAGVGRTGVLILSELMIYClehneKVEVPMMLRLLREQRMFMIQTIAQY
.| .  .||.|.. . .  |..|. .. .           .. .  ..||| ||.||||.|. . |. ..     .  .   ..|.|| |  .|... ..
eylklpfpddgtvPsleillrfldlvdefl.........nedpggvvaVHCkaGlgRtGtlvaaYLiyrl.....gmsaeeAialfrekRpgaipnqdyl

KFVY
. ..
eall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 943-1080 1.3e-08 29.2 In-house 3-124 (130) alignment 
Range on Protein: 943-1080
Range on HMM: 3-124/130.0
VPYEENRVEliptkenNTGYINASHIKVVVGGAEwhYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGgrtksHRYWPKlgSKHSSATYGKFKVTT
...| .|..       .  ||||| . ..   ||  |. || ||  |. |||.|. |. |||. .. . ||        |||   |.       .  ||.
lefevsrlq.......gntyinasfvGllgrtae..ylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd..sePlewyeediivtl

KFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH
  | ..    .. |.... |    ...  .| ..||  
tdrdefknikasnleiesdlneshqaltmfqisnwpsd
PTPc_motif_SM00404 1055-1169 2.8e-08 28.7 In-house 25-129 (140) alignment 
Range on Protein: 1055-1169
Range on HMM: 25-129/140.0
GLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVqgflSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYclehnEKVEVPMMLR
 |...| .. .|  ... .  .     .| |     .  ....   . .....|  ....  ..||| ||| |.. ||. .|| |     ..... . ..
klgithvinvteevsltkensgfqilqipldd....nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmry.....rqlslaeaye

LLREQRmFMIQTIAQ
...|.|  .|.  ..
fvkerR.piispnln
subfamily_PTPDC1_pd Subfamily PTPDC1 1116-1182 5.3e-08 27.5 In-house 116-176 (182) alignment 
Range on Protein: 1116-1182
Range on HMM: 116-176/182.0
PIVVHCSAGVGRTGVLILSeLMIYCLEhnekVEVPMMLRLLREQRMFMIQTIAQYKFVYQVlIQFLQ
 . ||| || ||||||| .  ..|  .    ..    ..|.|..|   |||  | ..| .   .||.
kvavhChaGlGrtGvliac.ylvyakr....ltaekaiklvrskrpksiqtreqvelvkef.alfli
DSPc Dual specificity phosphatase, catalytic domain 1057-1167 2.1e-07 25.9 Pfam-A 18-120 (133) alignment 
Range on Protein: 1057-1167
Range on HMM: 18-120/133.0
KVKHLLSGQERTVW--HLQYTDWPDHGCPEDVqgflSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMiycleHNEKVEVPMMLR
.... .. .... .    . ..  . ..| .     .  ..|..  . . ...|  ....  ..||| ||. |.. ||.  ||       ..... . ..
gitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm.....ktknlslneAye

LLREQRmFMIQTI
...|.|  .|   
fvkerr.skispn
DSPc Dual specificity phosphatase, catalytic domain 1057-1167 2.1e-07 25.9 In-house 18-120 (133) alignment 
Range on Protein: 1057-1167
Range on HMM: 18-120/133.0
KVKHLLSGQERTVW--HLQYTDWPDHGCPEDVqgflSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMiycleHNEKVEVPMMLR
.... .. .... .    . ..  . ..| .     .  ..|..  . . ...|  ....  ..||| ||. |.. ||.  ||       ..... . ..
gitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm.....ktknlslneAye

LLREQRmFMIQTI
...|.|  .|   
fvkerr.skispn
PTEN_1 1113-1141 1.8e-06 22.9 In-house 129-157 (196) alignment 
Range on Protein: 1113-1141
Range on HMM: 129-157/196.0
RHPPIVVHCSAGVGRTGVLILSELMIYCL
..  ..||| ||.||.|... . || .  
ngnvVlVHCkaGlgRsGtvvaayLmykgk
subfamily_PTEN_pd Subfamily PTEN 1097-1172 2.1e-06 22.8 In-house 99-171 (184) alignment 
Range on Protein: 1097-1172
Range on HMM: 99-171/184.0
QSVRRHTNSMLEGTKNRhpPIVVHCSAGVGRTGVLILSELMIYCLEHNeKVEVPMMLRLLREQRMFMIQTIAQYKF
... .. .. ||  |..   .|||| || ||||||| . |. ..| .. . |.  .    | .    ..  .| ..
eeivediekwleedkkn..vvvvHCkaGkGRtGvlivayllkslllek.aeealelfaeaRtknkkgvtiPsqrRY