Gene PTPN23 in Homo sapiens

Synonym: HD-PTP, HDPTP, PTP-TD14, PTPN23

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP079_AA protein Get Run
HsapP079_AA_1232-1512 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 1234-1519 1.9e-135 445.2 In-house 2-288 (288) alignment 
Range on Protein: 1234-1519
Range on HMM: 2-288/288.0
QELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL
.. |..|..|....|||....||...|...||.||||||..|| |||..|..|||.|||.||..||||||||.|..|||.||...||||||..|..||||
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVH
||.|||.||||||.|..|..|.||.||.|...|.....|.||..|.|||.|||||||||.|...|.. ..|..||.. .|||||.|.||..||.|..||.
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

A-HYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHG
. .. .||...||..||||.||||||.|||.||||.|.|.|||.....|.|.|.|.||..|.||| .|.|.||||......||...|
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG
BRO1 BRO1-like domain 76-440 3.2e-127 412.6 Pfam-A 1-375 (377) alignment 
Range on Protein: 76-440
Range on HMM: 1-375/377.0
PMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRV-PRDFEGCSVLRKYLGQLHYLQSRVPmgsGQEAAVPVTWTEIF-SGKSV
|.|.|.|||. .. .  ......|..|||....|...|..|. |||.||..  ||..|...| .|..||..|..|.|    ... |. ||.. | .|...
plislplKetkevdlskpLsdyIletygeesssyeddlaelnklRqaavtpssrdesglelllrYyaqLellekrfp...drslkveFtWydafdtgspl

AHEDIKYEQACILYNLGALHSMLGAMDKRVSEE----------CAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVAR
|......|.|..|.||.||.|...|...| |.|          .|||||.||.|.| .| |.|.|...| . |.|||.|||||.|||..||..|. |.|.
aqrslafEkasvlFnlaalysqiaasqnrssdeglkaAvkyfqrAaGafeylkenflhapseDlspetlkvlvklmlAqAqecflekaildkkkdsliak

ISAQVVDYYKEACRALENPDTASLlgrIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKG--QPDTVQDALRFTMD
..|||.|.|.||..||.. .|..    |.|.|.||||.| .||.|.||.......||..|.||..|..|.||..|.||.||||.  ........|.....
laaqvadlYeealealqesptktg...ipkewaklvqvKaeyfkAlahyyqalaleekkkyGeaiarLqeAlellkeaqklakkckskselledlkelke

VIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTD--PAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLRE
.|. |...|.|||||||.| ||. ..|...|.|.|||.||.| ..  ....|.|.|.||||.|.|||.||||||||||.|.
rikekleeaekdNdfiyleevpdeveltsikkaklvkalpinellsltkekgedlfkklvPiavheaaslyseekaklvrd
0050432 (Phosphotyrosine protein) phosphatases II 1220-1516 4.6e-75 248.1 In-house 15-304 (308) alignment 
Range on Protein: 1220-1516
Range on HMM: 15-304/308.0
RDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEhdARGRSIAIARCYSLKNRHQDVMPYDSNRVVLrSGKDDYINASCVEGLS-PYCPPLV
||.  ... |..  ..|  .  .. | | |.. ..||.. ..   . .|.|   .   |||. |..|||..||.| ....|||||| | | |  .    .
rdtsilvsslklsvldllkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfI

ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERG-QPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELG
|||.|||.| .||| ||.||.|.||||| .. |....| |.|.|.| | .....| ... | |. . .... |.| |.. . .  | . |.|...||. |
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhg

LPDSPSNLLRFIQEVHAHYlhqRPlhTPIIVHCSSGVGRTGAFALLYAAVQEVEAGnGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ
 |.||. ||.|...|. ..   ..   ||.|||| ||||||.|..|. ... .|.. | . ....|...|.|| .| | . ...|.|.|.. ... .|.
vPpspeilldflelvrksl...pg..gpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0046845 (Phosphotyrosine protein) phosphatases II 1252-1516 1.2e-71 236.7 In-house 5-279 (284) alignment 
Range on Protein: 1252-1516
Range on HMM: 5-279/284.0
VWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS-----GKDDYINASCVEGLS----PYCPPLVATQAPLPGTAADFWLMVHEQKVSV
 ..||.  . .    .|.|.. ..  |||..|..|||..||.|.|     . .|||||| |.| .     ...  .|||.|||.| .||| ||.||.|.|
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLVSEAEMEKQKVARYFPTErGQPMVHGALSLALSSVRSTETHVERVLSLQFRD-QSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHqRP
|||| .. |....| |.|.|.| |.....| ..  | |.   .... |.|.|.. .  .  | . |.|...||. | |.||..||.|...|. .. . .|
IVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lp

LHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNG--IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ
 . ||.|||| ||||||.|..|. . . .|...    . ....|.|.|.|| .| |   ..||.|||.. ..  .|.
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 1265-1512 1.4e-70 233.3 In-house 29-278 (297) alignment 
Range on Protein: 1265-1512
Range on HMM: 29-278/297.0
RGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLsPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE
  .|.|.  ..  |||. |..|||..||.| ....|||||| |.|   ..   .|||.|||.| .||| ||.||.|.|||||... |....| |.|.|.|
gslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywple

RGQPMVHGALSLALSSVRS--TETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlHQRPLHTPIIVHCSSGVGRTGAFAL
 |.....| ... | || .   .. . |.| ... . . .| . |.|...||. |.|.||. ||.||..|. .. .. | ..|..|||| ||||.|.|..
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfia

LYAAVQEVEA--GNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
.. ..| .|    .| . ....|. .|.|| .. |   ..||.|||.  .. 
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0051299 (Phosphotyrosine protein) phosphatases II 1240-1510 6.2e-70 231.2 In-house 18-285 (288) alignment 
Range on Protein: 1240-1510
Range on HMM: 18-285/288.0
RgqLGDVGALDTVWRELQDAQEHdaRGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMV
.  ....  |   ..||.. ...  . .|.|.  ..  |||..|..|||..||.|..    . .|||||| ..|  ..    .|||.|||.| .||| ||
l..angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg.ynlkrkfIatqgPlpntvedFWrmv

HEQKVSVIVMLVSEAEMEKQKVARYFPTerGQPMVHGALSLALSSVRSTETHVERVLSLQFR----DQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQE
.||.|.||||| .. |....| |.|.|.  |.....| ..  | |. . .. . |.| ..       .. .|   |.|...||. | ||||. ||.|...
weqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

VHAHYLhqrPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGnGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
|. ..    . . |..|||| ||||||.|..|. ... .|.. | ......|.|.|.|| .| |   ..||.|||.. .
vrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 1247-1509 2.7e-69 229.0 In-house 12-270 (273) alignment 
Range on Protein: 1247-1509
Range on HMM: 12-270/273.0
GALDTVWRELQDAQEhdARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVML
. |   ...|.. ..     .|.|.  ..  |||..|..|||..||.| .|..|||||| |.|  .. .  .|||.|||.| .||| ||.||.|.|||||
tllleefelllslkp..lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdg.ynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

VSEAEMEKQKVARYFPTERGQ-PMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhQRPLHTP
... |....| |.|.|.| |. ....| ..  | |. . .... |.| |.. . . .|   |.|...||. | |.|.. ||.||..|. ..  . | ..|
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale.alpsngp

IIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPeLPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
..|||| ||||||.|..|. ... .|...|.  ....|...|.|| .| |   ..||.|||.. 
vvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealle
DSPc_SM00195 1273-1510 1e-66 220.4 In-house 24-261 (263) alignment 
Range on Protein: 1273-1510
Range on HMM: 24-261/263.0
RCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLsPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP
   . |||.....|||..|| | . .    .|||||. ..|   .    .|||.||| | .||| || |.||..||||..| | .|.|..||.| | |..
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

MVHGALSLALSSVRSTE-THVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLYAAV
...| .|. | .| ...   . |.|.|.. ... .|.. .... .||. |.|||....|.....|. .. ..   ..||.|||| ||||||.|...  ..
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiil

QEVEAGNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
...|...  ... ..|...|.|| .| |.. ...|.|||... 
skleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1273-1510 1e-66 220.4 In-house 24-261 (263) alignment 
Range on Protein: 1273-1510
Range on HMM: 24-261/263.0
RCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLsPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP
   . |||.....|||..|| | . .    .|||||. ..|   .    .|||.||| | .||| || |.||..||||..| | .|.|..||.| | |..
kknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

MVHGALSLALSSVRSTE-THVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLYAAV
...| .|. | .| ...   . |.|.|.. ... .|.. .... .||. |.|||....|.....|. .. ..   ..||.|||| ||||||.|...  ..
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiil

QEVEAGNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
...|...  ... ..|...|.|| .| |.. ...|.|||... 
skleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0040438 (Phosphotyrosine protein) phosphatases II 1252-1526 1.4e-66 220.3 In-house 20-287 (317) alignment 
Range on Protein: 1252-1526
Range on HMM: 20-287/317.0
VWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLV
...| .| .. .   .|.|.  .   |||. |..|||..||.| . .    .|||||| |.|   ...  .|||.|||.| .||| ||.||.|.|||||.
lleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg.pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

SEAEMEKQKVARYFPTerGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhqrPLHTPII
.. |....| |.|.|.  |.....| ..  | |.   .  . |.| ..  . | .| . |.|...||. |.|.||. ||.|...|....    . ..|..
eleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvl

VHCSSGVGRTGAFALLYAAVQEVEAGNgIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVeqvlQRHGVPPPCKP
|||| ||||||.|...| ... .| ..  . ... |...|.|| .. |   ..||.|.|.  ..    .|... .| ..
VHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleyl....krkltlepase
0045450 (Phosphotyrosine protein) phosphatases II 1237-1510 1.9e-66 220.2 In-house 17-303 (307) alignment 
Range on Protein: 1237-1510
Range on HMM: 17-303/307.0
EAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS-----GKDDYINASCV--------EGLSPyCPPLVATQAP
. .. .| ..  |   ...|.. . ..   .|||   .   |||..|..|||..||.| |     . .|||||| |        .|    .   .|||.|
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgP

LPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErGQPMVHGALSLALSSVRSTETHVERVLSLQFR-DQSLKRSLVHLHFPTWPELGLPDSP
||.| .||| |..||.|.||||| .. |....| |.|.|.| |.....| .   | |.   .  . |.| ..     .  | . |.|...||. |.|.|.
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

SNLLRFIQEVHAhYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGI--PELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
. ||.||.||.. .|.. | ..|..|||| ||||||.|...| . . .|... .  . |.. |...|.|| .. |   ..||.|||.  .
eelldfieevrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 1278-1508 7.1e-66 217.3 Pfam-A 4-234 (235) alignment 
Range on Protein: 1278-1508
Range on HMM: 4-234/235.0
KNRHQDVMPYDSNRVVL--RSGKDDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALS
|||..|..|||..|| |  ..|. |||||. |.| .     ..|||.||. | .||| || ..||.|||||.|. |....|.|.|.|.|..... .| ..
knRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

LALS-SVR-STETHVERVLSLQFRDQS-LKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA
. |  ..   ..  . |.|.|. ....  ||.. .||. .||. |.|.||..||..|..|. .    .. ..|..|||| |||||| |..| ......||
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqlea

GNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
..  ... |.|...|.|| .| |.   . |.|.|..
eee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1278-1508 7.1e-66 217.3 In-house 4-234 (235) alignment 
Range on Protein: 1278-1508
Range on HMM: 4-234/235.0
KNRHQDVMPYDSNRVVL--RSGKDDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALS
|||..|..|||..|| |  ..|. |||||. |.| .     ..|||.||. | .||| || ..||.|||||.|. |....|.|.|.|.|..... .| ..
knRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

LALS-SVR-STETHVERVLSLQFRDQS-LKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA
. |  ..   ..  . |.|.|. ....  ||.. .||. .||. |.|.||..||..|..|. .    .. ..|..|||| |||||| |..| ......||
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqlea

GNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
..  ... |.|...|.|| .| |.   . |.|.|..
eee.vdvlqivkelRkqRpgmvqsleqYiflykail
0043336 (Phosphotyrosine protein) phosphatases II 1250-1509 3e-64 212.5 In-house 20-275 (278) alignment 
Range on Protein: 1250-1509
Range on HMM: 20-275/278.0
DTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVM
 ....| .. .. .   .|||.  .   |||. |..|||..||.| . .    .|||||| |.|  ....  .|||.|||.| .||| ||.|..|..|||
tllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg.ynvprkfiatqgPlpetvedFwrmvwelgvttivm

LVSEAEMEKQKVARYFPterGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhqrPLHTP
|... |....| |.|.|   |.....| ..  | .. . .. . |.| .  .  . .|  .|.|.. ||. |.|.|.| ||.|...|. ..    . ..|
LtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngp

IIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPeLPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
..|||| ||||||.|..|| ... .| . |.. |.. |...|.|| ...|   ..||.|||.  
vlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRD_pd Subfamily PTPRD 1260-1512 3.4e-64 212.4 In-house 33-282 (564) alignment 
Range on Protein: 1260-1512
Range on HMM: 33-282/564.0
QEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQ
.|..    . | . .   ||| .....||..||||.. .     |||||| ..|        .|||.||. | .||| || ||..|.|||| .  |..|.
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv

KVARYFPTErGqPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlHqrPLHTPIIVHCSSGVG
|...|.|.. | .  .| |   |..    .. . | ..|.  ..| .|   . ||  ||. | |.|. .||..|..|.|.  .  | . ||.||||.|||
kchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..pdagPivVhCSaGVG

RTGAFALLYAAVQEVEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
|||.|  . | .. ... ..  .. | |...|.||..| |..    |..||..  ..
RTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0039614 (Phosphotyrosine protein) phosphatases II 1253-1513 4.9e-64 212.0 In-house 35-291 (297) alignment 
Range on Protein: 1253-1513
Range on HMM: 35-291/297.0
WRELQDAQEHDARgRSIAIARCYSLKNRHQDVMPYDSNRVVLRS-----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLV
..| .. ..     .|||   .   |||..|..|||..||.| .       .|||||| |.| . ...  .|||.|||.| .||| ||.||.|.||||| 
llefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLt

SEAEMEKqKVARYFPTERGqpmVHGALSLALSSVRSTETHVERVLSLQFRDQSlkRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrPLHTPII
.. |... | |.|.|.| |   ..| ..  | .|   .  . |.|...  ..|  | . |.... ||. | |.|.. ||.|...|. .. .  | ..|..
klvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealael.pkggpvl

VHCSSGVGRTGAFALLYAAVQEVEAGNGIPeLPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ
|||| ||||||.|...| ... .| . |.  ... |...|.|| .. |   ..||.|.|.. .. .
VHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkr
0045098 (Phosphotyrosine protein) phosphatases II 1270-1513 7.4e-62 204.6 In-house 28-274 (278) alignment 
Range on Protein: 1270-1513
Range on HMM: 28-274/278.0
AIARCYSLKNRHQDVMPYDSNRVVlrsgkdDYINASCVEGLsPycPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPtErGQPM
|. ..   |||  |..|||..||.      |||||| ..|  |  .  .|||.||| |.|||| |..|....||||| .. |....| |.|.| | |...
alylgnldknRykdilpydhsrVk......dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.ggsl

VHGALSLALSSVRSTETHVERVLSLQFR----DQSLKRSLVHLHFPTWPELGLPDSP--SNLLRFIQEVHAHYL----------HQRPLHTPIIVHCSSG
..| ... | |.  ... . |.| ..          .| . |||...||. | |..|  . .|..........           .. . ..|..|||| |
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

VGRTGAFALLYAAVQEVeagNGIPELPQLVRRMRQQRKH-MLQEKLHLRFCYEAVVRHVEQ
|||||.....|   . .   .|   |.. |. .|.|| . ..| . ..||.||........
vgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 1273-1508 2.1e-59 196.2 In-house 7-240 (245) alignment 
Range on Protein: 1273-1508
Range on HMM: 7-240/245.0
RCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVeGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTerGQP
 .   |||  |..|||..||.| . .    .|||||| | ... ..| . |||.|||.| .||| |..|.....|||| .| |....| |.|.|.  |..
penkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

MVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHqrPLHTPIIVHCSSGVGRTGAFALLYAAVQ
...| ..  | |. . .. . |.|...    . .|  .|.|.  ||. | ||... ||.|...|. ..    . ..|..|||| ||||||.|...| ...
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmle

EVEAGNGIPeLPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
 .|.  |.. |.. |...|.|| .. |   ..||.|||. 
qlekelgvs.leeavkelrsqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 1272-1509 4.2e-59 195.5 In-house 8-244 (249) alignment 
Range on Protein: 1272-1509
Range on HMM: 8-244/249.0
ARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVeGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTerGQ
  .   |||..|..|||..||.| .      .|||||| .  .. ... ..|||.|||.| .||| |..|....||||| |. |....| |.|.|.  |.
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

PMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrPLHTPIIVHCSSGVGRTGAFALLYAAV
....| ..  | || . .  . |.| |..   . .|   |.... ||. |.|.|.. ||.||..|. .. .  | ..|..|||| ||||||.|...| ..
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylml

QEVEAGNGIPeLPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
. .|  .|.. |.. |. .|.|| .. |   ..||.|||. .
eqlekelgvd.leeavkllrsqRpgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 1269-1508 1.2e-58 193.9 In-house 4-239 (243) alignment 
Range on Protein: 1269-1508
Range on HMM: 4-239/243.0
IAIARCYSLKNRHQDVMPYDSNRVVLrSGkDDYINASCVEGLspycPPLVATQAPLPGTAAD----FWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPte
||.  .   |||..|..||| .||.| .| .|||||. ....    | | |||.|||.| .|    || |..|....||||| .. |....|.|.|.|  
iallpenlsknrysdilpydhsrvkl.eg.sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

rgQ-PmVHGALSLALSSVRSTETHVERVLSLQFRD-QSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH-----QRPLHTPIIVHCSSGVGRT
  .   ..| ..  | |.....  . |.|.|.  | . |.|  .|.|.  ||. | ||||..||.|..||....       ... . |..|||| |||||
..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GAFALLYAAVQEVeagnGiPELPQLVRRMRQQRKH-MLQEKLHLRFCYEAVV
|.....|   . .    |   | . |...|.|| . . |   ..||.|||. 
Gtliaaylmllll....g.vdleeavkllreqRpgkavqtpsqyrflyeall
ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV 474-760 2.3e-58 185.7 Pfam-A 6-294 (296) alignment 
Range on Protein: 474-760
Range on HMM: 6-294/296.0
HIPPQLMEKCAALSvRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISiTSKAELAEVRREWAKYMEVHEKASFTNSEL
 .|..|.||...|. ... ...|..|.. |.    .||..|......|.|.|  ..|... .|.  . . .|.   || |.|..|| | .|.|| ..|.|
glpesllekaeelr.seggiesleeslddleelkqavesildeakeqLdeeesedeklrskygarwtrq.psseltaelreelrkyreaLeeAsesDsql

HRAMNLHVGNLRLLSGPLDQVRAALPT--PALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLV---TTDHSEMKKLFEEQLKKYD
..... .  .|.|||.| ....|.||.  |  |.|.. ....|. .| |.......|  |...|.| |. |||.  |.    ...|....||||.|.|.|
rskleeieedlalLsspeeeleaslpssspeesdevseqikrlrelleklnllkaeRaklleeLkekihdddiskilielnkksssneeqlfeeeLekfd

QLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLdQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREA
.|. .|||....|...|..|.||| ... .... .   ..... ||.| ..|..|..|... .||..|| ||.... .|...... ..||..
plqerleqsiskQssllkelkeaneeflqdkkskyek.kerekvlqklenaydkykelssnleeglkFYndLlkileslrknvkdfvnarrs
subfamily_PTPN3_pd Subfamily PTPN3 1277-1512 8e-57 187.3 In-house 43-276 (280) alignment 
Range on Protein: 1277-1512
Range on HMM: 43-276/280.0
LKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPY---CPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTeRGQPMVHGA
 |||..|..|||. || |.... |||||. |.  .|        .||| ||. ||.||| ||.|||.|.|||| .  |  ..|  .|.|.  .. . .| 
sknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleyge

LSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAG
.|. ... ..|...| | | |. .... .|....| .  ||. |.||.....|.|...|..     .  ..|..||||.|.|||| . ||  |.. .|| 
fsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhCsaGigrtGvlilletalalieaa

NGIPELpQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
. .  | ..||.||.||. ..| .   .|  ||...  |
epvypl.divrtmrdqramlvqtasqykfvCeailkvye
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1243-1512 3e-56 185.8 In-house 17-281 (318) alignment 
Range on Protein: 1243-1512
Range on HMM: 17-281/318.0
LGDVgALDTVWRELQDAQEHDARGRSiaIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQ
 |..  |.. . .|.  .|. .. .|  .  .   |||......||. || |.  .     |||||. ..|        .|.||||| |  ||| || ||
sGel.llseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeq

KVSVIVMLVSEAEMEKQKVARYFPTErgQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhyLH
. .|||||  | |  |.||.||.| .  ... .|.|   |..  .....| | .... .... .|     |. .||. |.|.|...|| ....|..   .
nsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvsk..aq

QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
|.. ..||.||||.|||||| |  . . .. ..| . . .. | |...|.||. | | .    |.|....  ..
qksgagpivvhCsaGvGrtGvfiavdillerikaealv.Dvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRB_pd Subfamily PTPRB 1270-1513 2.6e-55 182.5 In-house 46-287 (293) alignment 
Range on Protein: 1270-1513
Range on HMM: 46-287/293.0
AIARCYSLKNRHQDVMPYDSNRVVLR----SGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTER
| . . . |||.....||| .|| |     . ..|||||. ..|..      .||| |||.|  ||| ||.|.|.|.||||    |  |.|  .|.|...
aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade

gQPMVHGALSLALSSVRSTETHVERVLSLQFrdQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHaHYLHQRPLHTPIIVHCSSGVGRTGAFALLYA
 .|...| ... | . ...| .| | |...   .. .|.. ..|| .||. | |.....||.|...|. .....   ..||.||||.||||||.|  |  
.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdr

AVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ
 .|..|  . . ..  .| ..|..|....| . .  | ...|.. ...
llqaieeedyv.difgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1265-1515 2.2e-54 179.5 In-house 30-280 (281) alignment 
Range on Protein: 1265-1515
Range on HMM: 30-280/281.0
RGRSIAIA-RCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVAR
.  . |       ||||..... ||  ||..    .. . |||||. |.|..      .|||.|.| . ..|| || |||||.|||.  | | .| |  |
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChr

YFPtERGQPMVHGALSLALSSVRSTETHVERVLSLqFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhyLHQRPLHTPIIVHCSSGVGRTGA
|.| .  . .  | . .   . ....|..||...|  |... .|....|.. .||. | |.....|| | .||.   |...  ..|...|||.||||||.
YWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk..ltekktkaplvihCsaGvGrtGt

FALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVL
.  |  .|..||| .   .. ..|. .|..|. |.|  .  .| | ||.. ... |
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPN6_pd Subfamily PTPN6 1230-1513 2.7e-54 179.2 In-house 10-299 (306) alignment 
Range on Protein: 1230-1513
Range on HMM: 10-299/306.0
RQLQQELEAfRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVL---RSGKDDYINASCVEGLSP-YCPPLVATQAPLP
.|  .|||   ..  .   .   . |||  ....   |. .    .  |||.. ..|.| .||.|       .|||||. ... ..  .   .|||  |.
eqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

GTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMvHGALSLALSSVRSTETHVERVLSLQ-FRDQSLKRSLVHLHFPTWPELGLPDSPSN
 | .||| || ...  ||||.  | |  |.| |||.|.|  ... .| .|.   | .|... . | ||..  .... .|.....|| .||. | | .|. 
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

LLRFIQEVHAHYLHQR-PLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA-GNG-IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ
.| |...|.... . .   . ||.||||.|.||||.| .. . .. .|  |.    .. .||. .|.||. ..| .   .| |.|.  ..|.
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1233-1511 5.5e-54 178.4 In-house 14-290 (298) alignment 
Range on Protein: 1233-1511
Range on HMM: 14-290/298.0
QQELEAFRGQLgDVGALDTVWRELQDAQE-HDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCpPLVATQAPLPGT
 |.|.| . .  ..  .......|.  ..  ..   ..| ..    |||..|....|| ||||..     . |||||| ... .    . .||||||. |
lqklaavkkkk.kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltet

AADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErgQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLR
 .||| || |.....|||| .  |..| |. .|.|.|  .   .| ... | |  .    . | | .. .... .|....||| .||. | |   . .| 
vedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

FIQEVHAhyLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
....|.|   .|.  ..|.||.||.||||.|.|  ... .. |.. . . .. | |...|..| ...| . .  |.|||| . .
llrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN13_pd Subfamily PTPN13 1271-1513 1.6e-53 176.8 In-house 33-271 (273) alignment 
Range on Protein: 1271-1513
Range on HMM: 33-271/273.0
IARCYSLKNRHQDVMPYDSNRVVLRSGKDdYINASCVEGL-SPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPM
  .    |||...|.|||  || | .    ||||| ..          .|.| ||| |..|||.|| |||..||.|. .| | .| |  ||.| ......
kkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

-VHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhyLHQrpLHTPIIVHCSSGVGRTGAFALLYAAVQ
 |.. | ..|  |   .. | | | ..  . .  | ..||.| .||. | | |. .||.|..||    |..   ..||.||||.|.||.|..  ......
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr..lqt..dagPivvhcsaGiGrsGtlitidvvlg

EVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ
 .|  . . .. ..||..|.||. ..| |    |.|.|..  ...
lierdkef.dvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPN12_pd Subfamily PTPN12 1271-1516 5.8e-53 174.7 In-house 36-282 (290) alignment 
Range on Protein: 1271-1516
Range on HMM: 36-282/290.0
IARCYSLKNRHQDVMPYDSNRVVLRSG----KDDYINASCVEGLSPYCpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERG
 .     |||..|..||| .||.|.      ..|||||. ..| .  .   .|.|.||| |  ||| |. |..|...||.  | |..|.| .||.| | .
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkl.eyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

QPMVHGALSLALSSVRSTE-THVERVLSLQFRdqSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLYA
... .|.... |.. . ..  .. | | ....  . .|..  .|.  ||. | | |...||..|..|. .  ..   ..|..||||.||||||.   .  
eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqese...daPlvvhCsaGvGrtGtiiaidy

AVQEVEAGNGIP--ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ
. . ..|..  .  .. .||...|.||. . | |   .. |.||.  |.. |.
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_PTPN9_pd Subfamily PTPN9 1254-1511 9.9e-53 174.1 In-house 20-290 (297) alignment 
Range on Protein: 1254-1511
Range on HMM: 20-290/297.0
RELQDAQEHDARGRSI-AIARCYSLKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVS
.| .. ... . |.   .  |. . |||..||. ||. |||| . ..    |||||. |.|       ..||| ||. |  |||.|| ||.| ||||   
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqk.kafiatqGplkktvsdfWrmvWeqevlvivmttr

EAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAH------YL----H
  |. . | ..|.|.|... . .| ||..  .|...| ...||| ..  ... .|...|  | .||. | |.| ..|| ....|  .      .|    .
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
 .|   ||.||||.|.||||.|. |  .....|  . . .. . |...|.|| ...|      ||| ||. . 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.dvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1253-1512 4.7e-51 168.7 In-house 26-284 (319) alignment 
Range on Protein: 1253-1512
Range on HMM: 26-284/319.0
WRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVS
 .| .. .| ..   . |     . |||.|....||  |||| . .     |||||| ..|        .||||||  |  ||| || |...|..|||  
ekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltk

EAEMEKQKVARYFPTErgQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSL-KRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPII
 .|  | |. .|.|.|  .... | | . | . . .|  . | |.|. . . .  |...| ..  ||. . |..   || ......    .... . ||.
lveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks..rektqsgPiv

VHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
|||| ||||||.|  | |... |.  . . .. . |.|.| ||. | |..   .|.|||..  ||
vhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1276-1515 1.2e-49 163.8 In-house 29-272 (274) alignment 
Range on Protein: 1276-1515
Range on HMM: 29-272/274.0
SLKNRHQDVMPYDSNRVVLRS--GKD---DYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ--P
. |||.....| .  ||.|.|  ..|   .||||  . | .      |||| ||| | ||||.|.....|.|||||    |...|| |.|||....    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

MVHGALSLALSSVRSTETHVERVLSLQFRDQslKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ
  .| ...  ... ... .  | |.|.   .  .||..|  .. ||.   ||....||....||.    ..    .|..||||.|.||||.|     ||.
erygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

EVEAGNGIPELpQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVL
.... . .  | ..|  .|..|  |.|..   .. ..|.. .....|
qlreeivvdvl.kivcnlrldrGGmvqtseqyelihralclylkrll
subfamily_PTPN1_pd Subfamily PTPN1 1253-1516 2.2e-49 162.7 In-house 8-276 (290) alignment 
Range on Protein: 1253-1516
Range on HMM: 8-276/290.0
WRELQDAQEHDARGRSIAIARCY--SLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEA
..|.    ...|.  ... |.      .||..|| |||  |..|.... |||||| || |       . || ||| |.. ||.|| |||   .|||    
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EMEKQKVARYFPTERG-QPMVHG--ALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrPLHTPII
| |..| |.|.|..   . ..     |.. | |  ...... |.| |. .     |...| |. |||..|.|.||...|.|...|      . . . | .
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdvGpav

VHCSSGVGRTGAFALLYAAVQEVEAGNG--IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ
.|||.|.||.|.|.|. . . ..|. .     .. . .  .|..|  ..| .  ||| | |..  .  . .
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1276-1511 3.6e-49 162.3 In-house 48-279 (288) alignment 
Range on Protein: 1276-1511
Range on HMM: 48-279/288.0
SLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErGQPMVH
  |||.....||| .|| |.      . |||||| ..|        .|||.||. |  ||| .|.|.|.| |||| .  | .|.|  .|.|.. ..|  .
akknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpkny

GALSLALSSVRSTETHVERVLSLQfrDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLYAAVQEVE
| . . | ... .| .|.| | |.   .  .. . .... .||. | |.|  .|| ... |.     .     ||||||| |||||| |  | |....||
Gsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidave

AGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
. . | ..   | ..|.||. . |.. .  |.||...  .
eedyi.DvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1277-1512 6.5e-49 161.4 In-house 11-243 (250) alignment 
Range on Protein: 1277-1512
Range on HMM: 11-243/250.0
LKNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQkVARYFPTERgqPMVHG
 |||. |....|| |||| . |     |||||| ..| .      .|||.||. |  ||| || |.|...|||| .  |.||. . .|.|.|.  .  .|
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyG

ALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA
 . . | |       . |.| |  . .. .| ...||| .||. | |.     | ....|.|   .|.   .|.||.||.||||.|||  ..| .. .. 
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqas..qqqagnaPvivqCsaGvgrsGafiaidavlerlkk

GNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
 . . .. ......|..| |... .    |.||.. . ..
ekvv.dvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1255-1510 1.2e-48 160.6 In-house 24-276 (315) alignment 
Range on Protein: 1255-1510
Range on HMM: 24-276/315.0
ELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEA
|..|  . |.  . .|  .    |||.....|.||.||.|     | ..|||||| ....       .|.|.||. .  ||| || ..||. |||.    
efhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkq

EMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLslQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRpLHTPIIVHC
| .| | ..|.| .... .  |.....| |. ..   | | |    |.   .| .   .|  ||. | .   | ||..|.|| |   ...  . ...|||
egdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngk.kefsllvhc

SSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
|.|||||| .  .   |.... .. . .. ..|. .|..| ...| . .  | |.||  .
saGvGrtGvvisidevvaqikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1275-1511 1.9e-48 160.2 In-house 46-283 (305) alignment 
Range on Protein: 1275-1511
Range on HMM: 46-283/305.0
YSLKNRHQDVMPYDSNRVVLRS--GKD--DYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV
   |||.......| .|. |.    .|  |||||| |.| .      ...|.||. | |||| .. | |||.||||.   | .|.|  .|.|.. .... 
nkaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke

HGALSLALSSVRSTETHVERVLSLQF-RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQE
.| .|. |.| .... ..|| |.. . .... .|....... .||. | |.... ||..|..|. .  ...   .|..|||| ||||||.|  .  |.. 
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd..qkkdkgvpllVhCsagvgRtGvfiavdialer

VEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
... . . .. ......|..|  |.|.. .  |...|.   .
lkkEevv.dvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Ptp69D_pd Subfamily Ptp69D 1276-1510 5.7e-48 158.6 In-house 49-285 (307) alignment 
Range on Protein: 1276-1510
Range on HMM: 49-285/307.0
SLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErgQPMVH
 ||||..|....|..||.|.      . |||||| ..|        .| |.|. .|. ||| |. ||.| .||||  . |....|.|.|.| |  . . .
alknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqy

GALSLALSSVRSTETHVERVLSLQFRDQS-----LKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrplHTPIIVHCSSGVGRTGAFALLYAA
| .   | | .... ...| |..   ...      .| .|  |. .|..   |...  ||..|..|. .| ..   ..||.|||| ||||.| |  |   
gdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsl

VQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
.|...| . . .. . |. .|.||. ..|      |.| |.. .
lqqlkaedkv.difetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1270-1509 1.7e-47 157.0 In-house 46-282 (297) alignment 
Range on Protein: 1270-1509
Range on HMM: 46-282/297.0
AIARCYSLKNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPycpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKqKVARYFPTER
|  .    |.|.....||||.|| |..  ||    |.||| |.|       |..|| | . | |||| || ...||.||||  . | .| | |||.. . 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

GQPmvHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPD--SPSNLLRFIQEVHAHYLHQRplHTPIIVHCSSGVGRTGAFALL
 ..   | .|. |.|| . |  ..| |...  .   .| .   .|  ||.   .   | | || .|.||. .. ..   ..|..|||..|||||| .  .
vtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna..egPllvhclaGvGrtgvllti

YAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
   | |..  . . .. .||...||.| ...| | . .| |.||. 
dsvvaeakrekev.difglvkklrqerpylvqtkeqykfvyvavle
subfamily_PTPRA_pd Subfamily PTPRA 1277-1510 3.4e-47 155.9 In-house 60-294 (330) alignment 
Range on Protein: 1277-1510
Range on HMM: 60-294/330.0
LKNRHQDVMPYDSNRVVLRS--G--KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErGqPMVHG
 |||  ...||| .||.|    |  . |||||| ..|        .|.| |.  |  ||| |. ||| . ||||    | ...| |.|.|.| |  . .|
eknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyG

ALSLALSSVRSTETHVERVLSLQ----FRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ
 . ...  .  ..    | . .|     ...  .| .  .|| .||..|.|  |  .|.....|..    ..    ||.||||.||||||.|  | | ..
nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl...nqqsagpivvhcsaGvGrtGtfivldavle

EVEAGNgIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
 |.| . . .. . |.|.|.|| .|.| .    |.|...  .
rvkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1270-1510 8e-47 154.5 In-house 38-275 (515) alignment 
Range on Protein: 1270-1510
Range on HMM: 38-275/515.0
AIARCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTER
|       |||.....||||.|| |     . . ||.||| ....       .|.|.|.. .  ||| .| ...|. |.|.    | .| | ..|.|   
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

GQPMVHGALSLALSSVRSTETHVERVLSLQFRDQslKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRpLHTPIIVHCSSGVGRTGAFALLYA
|. .  | ... | |. .    . | | .   |.   | .   ||  ||. | |   | ||..|.|| |   |.. .  |.|.|||.|||||| .  .  
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkad..hgq.ythpliihcsaGvGrtGvvisids

AVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
 | ... .. . .. ..|. .||.| ...| . .  | |.||  .
vvahakttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1278-1510 3.8e-46 152.8 In-house 64-291 (319) alignment 
Range on Protein: 1278-1510
Range on HMM: 64-291/319.0
KNRHQDVMPYDSNRVVLRS--G--KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVseaemeKQKVARYFPTERGQPmvHGA
|||  .....| |.| |.   |    |||||| |.|        .|.| ||. | |||| |. |...| ||.|       |.| ..|.| .  .   .. 
knriinilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eer

LSLALSSVRSTETHVERVLSLQF-RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHaHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA
  . ..||  |. .| | . |     .  .|..   ||  ||. | ||.||.|.|... |. |  ..   ...|.||||.||||||..  | . .. .. 
fkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr.hltskenhranivvhcsaGvGrtGvyivldvlldrmke

GNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR-H
 . . .. ..|| .||||....|.     |.| |..  |
ekqv.dvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1278-1510 9.7e-46 151.5 In-house 28-255 (284) alignment 
Range on Protein: 1278-1510
Range on HMM: 28-255/284.0
KNRHQDVMPYDSNRVVLRS--G--KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVseaemeKQKVARYFPTERGQPmvHGA
|||  .....| |.| |.   |    |||||| ..|        .||| ||. | |||| |. |...| ||.|       |.| ..|.| .  .   .. 
knrighilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eer

LSLALSSVRSTETHVERVLSLQF-RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHaHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA
  . ..||  .| .| | . |     .  .|..   ||  ||. | ||.||.|.|... |. |  ..   ...|.||||.||||||..  | . .. .. 
fkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvr.hltskenhranivvhcsagvgrtgvyivldvlldrmke

GNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR-H
 . . .. ..|| .||||....|.     |.| |..  |
ekqv.dvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1278-1516 1.3e-45 150.5 In-house 23-269 (270) alignment 
Range on Protein: 1278-1516
Range on HMM: 23-269/270.0
KNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGA
 ||..|..|    ||.| . ..|    ||||  |.| .      .|...||| |  .|| |. |.||. |||.    |  ..| .||.|.|... .   .
lnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkled

LSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPS------NLLRFIQEVHAHYLHQRPLHtPIIVHCSSGVGRTGAFALLYAAV
  ..  .. .. ..  ..  |. .... .| ||| .. |||. | | ..       .||. ...|...  ...  . |..|||| |||||| . .|  ||
gkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiav

QEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ
. .|  . . .. ......|..|  ..|   . .| |.||| ..|....
rlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_PTPN14_pd Subfamily PTPN14 1273-1512 5.9e-45 148.5 In-house 47-297 (300) alignment 
Range on Protein: 1273-1512
Range on HMM: 47-297/300.0
RCYSLKNRHQDVMPYDSNRVVLRSGKD---DYINASCVE-GLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE--RG
     |||..||.||. ||| | . |.   .||||| ..  ..      ...|.||. |  ||| || ||.|..|||| .| |  |.|  .||| .  . 
penaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskk

QPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRP------LHTPIIVHCSSGVGRTGAF
. . .|   .    ...... . . | |..   . .|...|| .  ||. |.|. ... | ...||..   .          . |..|||| ||||||  
ktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvl

ALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
 |    .. .| .. | .... ..|.|.|| ...|     .| |........
ilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRN_pd Subfamily PTPRN 1244-1515 1.3e-44 147.1 In-house 26-296 (297) alignment 
Range on Protein: 1244-1515
Range on HMM: 26-296/297.0
GDVGALDTVWRELQDAQeHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQK
 .   |.  |  | . .  . . ...| |  .  |||...|.||| .|| |..     |.|||||| .    |  |  .|||.||. | |||| || || 
knkdrlekewealcaye.aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

VSVIVMLVSEAEMEKQKVARYFPTErGQPmVHGALSLALSSVR-STETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlh
| |||.| . .| . ....||.| | |.  |...  . | |    .. .. | . |.  ..|  |..  .|| .||| | | |. .|| | . |   |  
vvvivnltrleeegvkqckrywpde.Gse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy..

qRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVL
 |   .||.||||.|.||||.. |.   .. .  |    ..   .  .|.||..... |  ..|.. ||.. |...|
.rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1277-1508 6.9e-44 145.0 In-house 51-276 (315) alignment 
Range on Protein: 1277-1508
Range on HMM: 51-276/315.0
LKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTErgqPMVHG
 |||. ....||  || |       . ||.||. ..| . .    .|.|.|.. .  ||| .|.|.... |||| . .| ||.|. .|.| .    ...|
qknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyG

ALSLALSSVRSTETHVERVLSLQFRDQSlkRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRplhTPIIVHCSSGVGRTGAFALLYAAVQEVEA
 ..... |    .    | ||  |.|.   | .| ||. .||. |.| .  .|. .|. |. |   .    ..|.||||.||||||.|  | | ....||
kitvtrkseevnteytvrtlsvvfgdni..revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaea

GNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
 | | .. ......||.|..|.|     .| |.|..
enai.dvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1268-1512 1.2e-43 144.1 In-house 40-279 (287) alignment 
Range on Protein: 1268-1512
Range on HMM: 40-279/287.0
SIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGq
 ..||     ||| ......| .||.|.  ..|||||. ..| .      .....|.  || .|| ......|..||||. | | ....  .|.|.|.  
thniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekk.afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

pMVHGALSLALSSVRSTETHVERVLSLQFRD-QSLKRSLVHLHFPTWPELG-LPDSPSNLLRFIQEVHAhylHQRPLHTPIIVHCSSGVGRTGAFALLYA
 .| |  ...| .   ..  .|| | .. .. .. |....  .. .|.. | ...  . || . . ...   .... .|.|.|||| .|||.. |     
.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt...qrkrgntsivvhCsdtvGrsamfcaaat

AVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
......   .| .. |.....|.|. ...|   . .| ...|. ...
tinkckteGvi.Dvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPRG_pd Subfamily PTPRG 1253-1511 1.8e-43 143.6 In-house 25-287 (563) alignment 
Range on Protein: 1253-1511
Range on HMM: 25-287/563.0
WRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRS--G---KDDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLV
. .||    ..    . . ...   |||. ....||. || |..  |   | |||||. ..|        .||| ||. |. ||| |. ||.|..|||. 
fealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqk.skafiatqgplkdtfddFWrmiWeqnvaiivmit

SEAEMEKQKVARYFPTerGQPMVHGALSLALSSVRSTETHVERVLSLQF-----RDQ-SLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhQRP
   | ...|  .|.|.   ...  |||.. | .   . .  .| |...       .|   ..   . |...||. | |...   | |..   |    .. 
nlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa...nka

LHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
   ||.||||.|||||| .  | . ...... | . .. ......| || ...|..    | ..|..  .
eaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1255-1511 1.3e-42 141.1 In-house 28-288 (325) alignment 
Range on Protein: 1255-1511
Range on HMM: 28-288/325.0
ELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLvSEA
|..     |.  . .|       ||| ..|...| .|||| . ||    |||||| ..        ..|.||||. |  |.| .| . . ||.|.|  | 
efgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWrcsvvvvl.nel

EMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQ---RPLHTPII
. .|.. | |.| | |.    |.| . | ..     .| ||| ..  ..   ||.  ... .|...| .  |. |. ..| |.|            |||.
dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpil

VHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
||||.||||||.|. ||.|...|     . .. . |...|..|  |..      ..|||.|  .
vhcsaGvGrtGvfislysalakvieesrv.difgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1270-1514 4.9e-41 135.5 In-house 41-286 (290) alignment 
Range on Protein: 1270-1514
Range on HMM: 41-286/290.0
AIARCYSLKNRHQDVMPYDSNRVVLR--SGKDD----YINASCVEGLSPYCpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPT
...   .|.|| .....|| ||..||  ||. |    ||||. ..| .      .|||.|.. |..||| .. ..||..||||... |..|.|   |.|.
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekk.qyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpd

ErGQPMvHGALSLALSSVRSTETHVERVLSLQFRDQ-SLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFAL
. .. .  |  |. |.. ..... .|| |... ...   |.|...... .|.. |    |.  |  |.|.     . ..  |.|.|||| .|||.. |  
s.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt..qrkrgntsivvHCSdtvgrsavfca

LYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQV
.. ... ..   .| .. |.....|.|.  ..| . .... .. |.. ....
aattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPRK_pd Subfamily PTPRK 1277-1508 7.4e-41 135.0 In-house 45-274 (314) alignment 
Range on Protein: 1277-1508
Range on HMM: 45-274/314.0
LKNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQpmvHG
 ||| .|...||  ||.| . ..|    ||||. ...        ..|| ||. | .||| .|.... . ||||    |  . |  .|.| .  .   .|
eknrsgdilaydrsrvflitidgdpssdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...yg

ALSLALSSVRSTETHVERVLSLQF--RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEV
 . . | ..   .  | |.....   | |. .| . ...| .||. . | |   ||.....|...   | . . .|.||||.| ||||.|  .   .. .
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkks...qeeeaGrivvhCsaGaGrtGtfiaidivldmi

EaGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
|  .|. .. . |. .|...  |.. .   .|.|....
e.regvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1267-1497 8.2e-40 131.2 In-house 48-269 (290) alignment 
Range on Protein: 1267-1497
Range on HMM: 48-269/290.0
RSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKD-DYINASCVEGLSpycPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTER
|.|  .     |||..||.  |  ||.|. | | ||. |  |.||    .... || .|  |. |.| || ..||..||||    |  | | ..|.| . 
rkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

GQPMVHGALSLALSSVRSTETHV-ERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVhahylhqRPLHTPIIVHCSSGVGRTGAFALLY
|. .  |....  |   . ....  ..||.. .|.  .  | ||.  .||.  .. |   ||| .. .       | .  |..||||.|.||||.|. . 
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.......rkasGpvvvhcsaGiGrtGtfvaie

AAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEK
...| .  |  . .| .||| .|. |   .|  
vglqilldGkel.dlldlvralrnsrlnsvqvd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1276-1510 8.1e-39 128.1 In-house 39-276 (287) alignment 
Range on Protein: 1276-1510
Range on HMM: 39-276/287.0
SLKNRHQDVMPYDSNRVVLRSGK---DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPtERGQPMVHG
  |||. ||.|.| .||.|        |||||  | .        .|.|.|.. |  ||| .| |.......... | |  ..|. .|.| || .||  |
vkknryadvlPiddtrvllsaegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP.erevPmrvG

ALSLALSSVR--STEtHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPL--HTPIIVHCSSGVGRTGAFALLYAAVQ
  |. | .    . | .  | | |   .    | .  |.. .||. .|. .   |.||. .|. |   .|      |..||.. |.||.| .  ... |.
GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

EVEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
  |   |  .  . | |.|..|. ..|  . ||. |||.| .
rled.lGrvdvaavvirlreyraalvqavvqlrllyealvty
0051429 (Phosphotyrosine protein) phosphatases II 1299-1514 1.2e-37 125.4 In-house 4-228 (272) alignment 
Range on Protein: 1299-1514
Range on HMM: 4-228/272.0
DDYINASCVEGLspycPP------LVATQAPLPGTAADFWLMvHEQKVSVIVMLVSEAEMEKQKVARYFP----------TERGQPMVHGALSLALSSVR
..||||. | |.            | ....||| |||||| . .|.....||.| || |....|. || |           .  ... .|||.. | |. 
sgyiNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

STETHVERVLSLQFR-DQSLKRSLVHLHFPTWPELGLPDSPsnLLRFIQEVHAhylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPE---
 .. .. |.| | .  . .  | . |||.  ||  | |...  ||........        . |..||||.|..||| ...|.  .. |..   . .   
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----LPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQV
    | . |...|.|| .. |   ...|.|||..  .. .
tnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1267-1508 5.1e-37 122.3 In-house 25-263 (283) alignment 
Range on Protein: 1267-1508
Range on HMM: 25-263/283.0
RSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSP--YCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTE
  || |.    |||.|...|.| .|| |.|   |||||. .            ...|.||  |  ||| ||...|.. ||||    | ...| ..|.| .
adiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

rGQpMVHGALSLALSSVRSTETHVERVLSLQFRD--QS-LKrsLVHLHFPTWPELGlPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFA
 |  . .| . ..|    . .. . . | |.     .| |   | |  .  | | | .... | |  .  | .    ..  ..||.||||.|.|||..| 
.Gs.edyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleyg.eqaiinslvkfnkvisl..qteskkgPivvhCstgiGrtavfi

LLYAAVQEVEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
 . |.|... . . . .... |. ||.||  ..|..   .. .|.|.
aasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1277-1506 3.1e-35 116.5 In-house 5-234 (237) alignment 
Range on Protein: 1277-1506
Range on HMM: 5-234/237.0
LKNRHQDVMPYDSNRVVLRS--GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTeRGQPMVHGAL
.|||. ... || .||||.   .. |||||. ..|.       .|.| ||  .  ||| || ..| ||||||    | ...|  .|.|    ||  .| |
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvl

SLALSSVRSTETHVERVLSLQFRDQSLKRSLVH-LHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQrPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAg
...|        .  | | |. | .  .  |.|  .| .||. |.|.  . |||| ...  .  |  .  .| |.|||.|||||| | .. | ... .  
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphv.sesgpwiihcsagvgrtgiflvidamlrqake.

NGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEA
. . .. . |  . ..| ...| | .  | ...
kkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1254-1510 7e-34 111.9 In-house 24-235 (392) alignment 
Range on Protein: 1254-1510
Range on HMM: 24-235/392.0
RELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSE
 |..|  . |.  ...|       |||.....||||.||.|     . ..||.||| ....       .|.|.| . .  ||| ||....|. |.|.   
eefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtkl

AEMEkqkvaryfptergqpmvhgalslalssvrstethvervlslqfrDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHqrpLHTPIIVH
 | .                                                .|.    ||  ||. ..|   |.||.||.||.|.. .      |.|.|
kegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq...ythpliih

CSSGVGRTGAFALLYAAVQEVEAGNgIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRH
||.||||||    . . |   .    . .. ..|  .|..| .|.| | .  | | ||.  
csagvgrtgvvisidsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygavled
0041856 (Phosphotyrosine protein) phosphatases II 1278-1508 1.4e-33 111.4 In-house 4-168 (182) alignment 
Range on Protein: 1278-1508
Range on HMM: 4-168/182.0
KNRHQDVMPYDSNRvvlrsgKDDYINASCVEGLSPYCPpLVATQAPLPGTAADFWLMVHEQKVSVIVMLVseaemekqkVARYFPtergqpmvhgalsla
|||..|..||| .|        |||||. . |  | .   .|||.||..| |||. |..|.....||.|            .|.|               
knrysdilpydhsr......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

lssvrstethvervlslqfrdQSLKRSLVHLHFPTWPELGLPDsPSNLLRFIQEVHAhylhqrpLHTPIIVHCSSGVGRTGAFALLYAAVQEveagnGiP
                     . |.|  .....  ||  | || .. ||.||.||..        . |..|||| ||||||.....|   .      |  
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.v

ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
 |.. |. .|..| .| .   ...|.. |. 
sleeavklvrsrRpgmvitpnqyfflqlall
0036282 (Phosphotyrosine protein) phosphatases II 1299-1505 2.9e-33 110.4 In-house 2-164 (174) alignment 
Range on Protein: 1299-1505
Range on HMM: 2-164/174.0
DDYINASCVEGlSPYCPPLVATQAPLPgtaadFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTergqpmvhgalslalssvrstethvervlslqfRD
.|||||| . . |   | |.|.|.||.     || |..|......||| .| |... |. .|.|.                                 . 
sdyinaspldl.syitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

QSLKRSLVHLHFPTWPELGLPDSPSnLLRFIQEVHAHYLHqrPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEagNGIPELPQLVRRMRQQRKHMLQEKL
..|.|. .....  ||  | ||..  ||.|...|. ....  . . |..|||| ||||||.....|   .  .  ..  .  .|||..|.|| .| |   
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtps

HLRFCYE
..||.|.
Qyrflyy
subfamily_CG7180_pd Subfamily CG7180 1278-1511 6.6e-33 108.6 In-house 45-290 (296) alignment 
Range on Protein: 1278-1511
Range on HMM: 45-290/296.0
KNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKqKVARYFPTE----RGQPM
|||. .|.||| |||||..     |.|||||. |...       . |.||   |  .|| .|.....| .|.|  . ...| ..  |.| .     |. .
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk.eyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeif

VHGALSLALSSVRSTETHVERV-LSLQFRDQSL---KRSLVHLHFPTWPE-LGLPDSPSNLLRFIQEVHAHYLHQ--RPLHTPIIVHCSSGVGRTGAFAL
|.   .  .. ... . .. .  ..|  ...     .| . .... .|.    .| | . |. ... |.    .   .| . |..|..| |..|.|..  
veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyla

LYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
. |... ||  . . .. . |...|..|....... . ...|. .  .|
idanlelvekeeev.dvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1270-1517 4.4e-32 106.1 In-house 28-265 (267) alignment 
Range on Protein: 1270-1517
Range on HMM: 28-265/267.0
AIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEmekQKVARYFPTERGQPM
 ||     .|| .|..||| .||.||  ...||||| |||       ...|| ||  | .||. ..|.|||.|||.|    .   ... ...| . ||  
siaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvft...dnirlfwPPkmgqak

VHGALSLALSSVRSTETHVERVLSLQFRDQSLKRsLVHLHFPTWpELGLPDSPsnLLRFIQEVHAHYLHQRpLHTPIIVHCSSGVGRTGAFALLYAAVQE
 .  |..  |  .  . .   .| |.|...| .  ..  ..  | ..   . |   |. .  . |.   .     |..|.|| ||||.|.|  ... .. 
kyqdltvehslekeendyqiitlelkfknesahn.vtlyyykkw.nintnnkp..ylkplfgilaknqlen.gnrPlvvacsdGvGrsGtflvidsqler

VEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQR
.   .|. .. ...|..|.||  ... | .  ...| .. . |  |..
akt.egvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlke
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1249-1509 5.8e-31 102.6 In-house 18-269 (288) alignment 
Range on Protein: 1249-1509
Range on HMM: 18-269/288.0
LDTVWRELQDAQEhDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVS
.... .| .|. . .|  ..|      . ..|....   |  || |    | ||.|  |   ..|   |. .|||| ||   .| |. |. |  ||||  
veglkkeyrdspn.easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlce

EAEMEKQKVARYFPTERGQPMVHGALslaLSSVRSTETHVERVLSLQF--RDQSLKR--SLVHLHFPTWPELGLPDSPSNLLRFIQEVhahylhqRPLHT
  |  |.| | |||.. |. .  | |    . |.   . .......      .  .    . .||.  |.. |.|..    ||... .       . |. 
llekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqk

PIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
||.||.| ||||||...|   |.. .   . .  ...|. ..|..|.. .| .    . .  |  
PivvhssaGvGrtgtlililialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvle
0046846 (Phosphotyrosine protein) phosphatases II 1299-1510 1.1e-30 102.0 In-house 12-172 (176) alignment 
Range on Protein: 1299-1510
Range on HMM: 12-172/176.0
DDYINASCVEGlspYCppLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMvhgalslalssvrstethvervlslqfrd
 |||||. . |   ..   .|||.|||.| |||. |..|......|.| .| |... |...|.| ...  .                             
ldyinanlilg...sr..piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

qslkrslvHLHFPTWPELGLPDSpSNLLRFIQEVHAHYLHQrplhTPIIVHCSSGVGRTGAFALLYAAVQeveagNGIPELPQLVRRMRQQRK-HMLQEK
        . ..  ||. | ||. . ||....... .. .      |..|||| |.||||.....|         .    . . ....|.||  ...|  
........qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqtp

LHLRFCYEAVVRH
 ..||.||.. ..
eQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 1299-1505 1.4e-30 101.7 In-house 5-155 (172) alignment 
Range on Protein: 1299-1505
Range on HMM: 5-155/172.0
DDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEaemekqkvaryfptergqpmvhgalslalssvrstethvervlslQFRD
.|||||| ...     . ..|||.||. | |||| |..|.....||.| ..                                             .   
sdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

QSLKRSLVHLHFPTWPELGLPdSPSNLLRFIQEVHAHYlhQRPLHTPIIVHCSSGVGRTGAFALLYAAVqeveagNGIpELPQLVRRMRQQRKHMLQEKL
. |.|. .....  ||  | | ... ||.|.. .. ..  ..  . |..|||| ||||||.....|          |.  | . |. .|..| .. | . 
ellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnps

HLRFCYE
..||.|.
qyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1270-1511 8.3e-30 98.6 In-house 42-279 (439) alignment 
Range on Protein: 1270-1511
Range on HMM: 42-279/439.0
AIARCYSL-KNRHQDVMPYDSNRVVL----RSGKDDYINASCVEGLspYCPP-LVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKqkvarYFPT
 .|. |.  |||..|| ..|  ||.|       .  ||||  ..|   | .   .|||.|   |. ||| .| |.|.. ||||    |  |     |.|.
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy..yddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

ERGqpMVHGALSLALSSVRSTETHVER-VLSLQFRDQSLK-RSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhQRPLHTPIIVHCSSGVGRTGAFA
.    ...| ...          .| | .  .. ||.. | |.....|. .||.  .|   | .| |.. . .    ..    |..||||.||||||.  
dae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan..dkeeygpvvvhcsagvGrtGtii

LLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
 |  |.... . | . ..  .|. .|.|||.|.|.  .  | |.||.  .
aldialeqlklenkv.dikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1276-1506 1.8e-29 97.3 In-house 56-284 (305) alignment 
Range on Protein: 1276-1506
Range on HMM: 56-284/305.0
SLKNRHQDVMPYDSNRVVLR-SGKDDYINASCVEglSPYCP--PLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP--MV
  |||.|||   | . | |      ||| |  |    |  |   ....| ||  |  .|| || ..||  ||||.   |. | |.|.|.|. .|.   . 
itknryqdvpcqdqsavkldkpspsdyihanyvg..cpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

HGALSLALSSVRSTETHVER---VLSLQFRdQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVhahylhqRPLHTPIIVHCSSGVGRTGAFALLYAAV
 | .   .|  .  |   |    .| | .   . | |. ||..  ||. |.|      | ..  .       |  . ||.||||.|.||||.   .   .
sgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsai.......rgskvpivvhcsagigrtgtivaieyil

QEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEA
...   .  | .|.||. .|.|| . .|. ..  | .  
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrv
0049772 (Phosphotyrosine protein) phosphatases II 1277-1511 6.6e-29 97.0 In-house 48-280 (314) alignment 
Range on Protein: 1277-1511
Range on HMM: 48-280/314.0
LKNRHQDVMPYDsNRVVLRS---GKDDYINASCVEGLspycPPLVATQAPLPGTAADF----------WLMV--HEQKVSVIVM----------------
 |||..|..|.| |||.| .      |||||| | |        .|||.||. |  ||          | ||   ...| .|||                
dknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaA

-----LVSEAEMEKQKVARYFPTERgqpmvhgalslalssvrstethvervlSLQFRDQSLKRSLVHLHFPTWPElGLPDSPSNLLRFIQEVHAHylhqr
     | .  .   . .|..... .                           . .. .. ..|  ....   .|  | ..... ...|.. ....     
lgKtpllildgngneptaadlellk...........................eelydpelferlgikylripvpD.gsaplledfdeflefieea.....

PLHTPIIVHCSSGVGRTG-AFALLYAAVQEveagnGIpELPQLVRRMRQQRK-----HMLQEKLHLRFCYEAVVRHV
. ..|..|||..|.|||| . .. |   .      |.  | . ....|..|      ....  ... |..||.  ..
dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1261-1500 1.3e-28 95.0 In-house 27-266 (307) alignment 
Range on Protein: 1261-1500
Range on HMM: 27-266/307.0
EHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSG--KDDYINASCVeGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVA
...  | ..   .. . |||.|||   | .|.|..      ||| |  . |..     ....| ||  |  .|| |. ..||  ..||.   |. | |. 
kktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikce

RYFPTERGQPMVHGALSLALS----SV--RSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLlrfIQEVHAHYLHQrplhTPIIVHCSS
.|.| |.|| .|.|  . ..|     .   . . ..  | .|.    .  |.. || .  ||. | |.   .    |  ..|   ..     |..||||.
qywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlta...inlleavrydt....npvvvhcsa

GVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHL
||||.|.   .    . . ||    .. .||. .|.||.. .|...  
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1278-1511 1.3e-28 94.7 In-house 51-287 (305) alignment 
Range on Protein: 1278-1511
Range on HMM: 51-287/305.0
KNRHQDVMPYDSNRVVLRSG-KDDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHG----
|||..||   | ||| |..    .|| |  |   .     .. |||||  | |||| |  ..||  | ||    |   .| . ||... .. .       
knrykdvgcldnnrvklegpwpheyihanyvstpt.npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgq

------ALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEvhahylhQRPLHTPIIVHCSSGVGRTGAFALLYAA
        | .|. .......|..   .     . .|   | |.  ||. |.| .   .| ....        ||.. ||.||||.|.||||.  .|   
kisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek.......arpskgpivvhcsagigrtgsvvmleyi

VQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
.... ||. | .  ......|.||.  .|      | .. .. ..
ldqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
PTPc_DSPc_SM00012 1405-1507 3.7e-28 93.2 In-house 2-103 (105) alignment 
Range on Protein: 1405-1507
Range on HMM: 2-103/105.0
LVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPlHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCY
. |.|...||. |.|......|.....|. .. ..   ..|..|||| |||||| |..|. ..| .|.... ... |.|...|.|| .| |..    |.|
vkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAV
.|.
ral
0049260 (Phosphotyrosine protein) phosphatases II 1316-1505 2e-27 91.1 In-house 10-144 (152) alignment 
Range on Protein: 1316-1505
Range on HMM: 10-144/152.0
PLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFptergqpmvhgalslalssvrstethvervlslqfrdqslkrslvHLHFPTWPE
. .|||.|.| |.|||| |..|.....|||| .. |. | |...|.                                             . ..  || 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpD

LGLPDSPSNLLRFIQEVHAHylhQRPLHTPIIVHCSSGVGRTGAFALLYAAVqeveagNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYE
 | ||..  || ... .. .   ..  . |..|||| ||||||.....|         .|  .| . |...|..|... . . .|||.||
hgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lg.vsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1273-1508 3e-27 90.3 In-house 5-237 (239) alignment 
Range on Protein: 1273-1508
Range on HMM: 5-237/239.0
RCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQp
|    |||. ... || .||||       . |||||| .          .|||  .  .. ||| |. ...  |||||    |  |.|. .|.|    . 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

mvHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhqrPLHTPIIVHCSSGVGRTGAFALLYAAVQ
  .  | ..|        .. | . .    |. .| . . ||  ||. |.|.  . .| . ...    |   |   | ..|||.|||||||| .. | ..
..ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl...pgarpwvihcsagvgrtgaflvidamlr

EVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
. .  . . .. . |. .|..| ||.|   .  | . ||.
qakkqktv.difnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1272-1507 3.1e-27 90.3 In-house 5-237 (239) alignment 
Range on Protein: 1272-1507
Range on HMM: 5-237/239.0
ARCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ
 |    |||. ... || .||||       . |||||| .          .|||  .  .. ||| |. ...  |||||    |  |.|. .|.|    .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

pmvHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhqrPLHTPIIVHCSSGVGRTGAFALLYAAV
   .  | ..|        .. | . .    |. .| . . ||  ||. |.|.  . .| . ...    |   |   | ..|||.|||||||| .. | .
...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl...pgarpwvihcsagvgrtgaflvidaml

QEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAV
.. .  . . .. . |. .|..| ||.|   .  | . ||
rqakkqktv.difnyvkairedrphmvqtseqyvfihlav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1259-1505 5.4e-27 89.3 In-house 24-287 (301) alignment 
Range on Protein: 1259-1505
Range on HMM: 24-287/301.0
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGK------DDYINASCVEGLSPYcPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM
 .|.. .  .. .    .  ||.... .|| ||..|.  .       .||||| ..| |      .|.|.|.  | .||| .. ..|.. |||.  . | 
lkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkeg

EKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSL---------------KRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHyl
 |.|  .|.|. . .    | ..  |..      .| | |... .| |                 .... |.   ||. |.   |   |. |..|     
tkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr..

HQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAgNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYE
 |..   |..|||| .|.|.| .  .  ..  . | .|. .. |.....|...  . .      . |.
qqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiyd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1279-1509 7.8e-27 89.0 In-house 39-268 (285) alignment 
Range on Protein: 1279-1509
Range on HMM: 39-268/285.0
NRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
||. ||   .  ||||.    ||| || .          ..|| ||| | .||| |....|.. ..||..  |   .|.| |.| . |. .  |   ..|
nryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitl

SSVRSTE---THVERVLSLQFRDQSL-KRSLVHLHFPTWPELGLPDSPSNLLrfiqEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFA-LLYAAVQEVEAG
. ..      | .. .  ..  | |     . |.. | ||.   |.    ..    |..    .  |  .|| ||||.||||| .|  . ||... .|  
teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmi....elykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenp

NgIpELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
| | |. ..|| ||  | . .| .... | |  .. 
n.i.emldivremramrfqavqshmqflflyvvlme
0051082 (Phosphotyrosine protein) phosphatases II 1299-1506 3.1e-26 87.2 In-house 3-148 (151) alignment 
Range on Protein: 1299-1506
Range on HMM: 3-148/151.0
DDYINASCVEGLspycppLVATQAPLPgtaaDFWLMVHEQKVSVIVMLVSEAEMEkqKVARYFPTERgqpmvhgalslalssvrstethvervlslqfrd
.||||.| |.|       | ....||.    ||. ...|.....||.| || |..  . ..|.| .                                  
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qslkRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAhylhqrPLHTPIIVHCSSGVGRTGAFALLYAAVQEveagngiPELPQLVRRMRQQRKHMLQEKL
    . ..|.... ||. |||.|.  .|.|.... .      . . |..||||.|.||||....||   .          | . .. .|..| .. | . 
....ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnq

HLRFCYEA
. .|.. |
qflfqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1294-1500 3.8e-25 83.3 In-house 70-270 (301) alignment 
Range on Protein: 1294-1500
Range on HMM: 70-270/301.0
LRSGKDDYINASCVEGLsPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTE--THVERv
.  ||   | |  ..        ..|||.||. |. ||| |.   .|  ||||  . | ...| . |.|.. .. .  |  .. . .  .      ..| 
ivdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskr.

lSLQFRDQSL---KRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQ
 .|. .| .     |...|  . .|.. |.| |  .|  ... |          . ||.||||.|.||. ||       .|||| . | || . ....|.
.tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.......ekPivvhcsaGiGrsvafigteylareveadpti.eltealkhlre

QRKHMLQEKLHL
.| . .| .  |
hrwngvqtnsql
0044763 (Phosphotyrosine protein) phosphatases II 1286-1508 1.6e-24 81.9 In-house 1-168 (178) alignment 
Range on Protein: 1286-1508
Range on HMM: 1-168/178.0
PYDSNRVVLRSGKD----DYINASCVEglsPYcppLVATQAPLpgtaADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGqpmvhgalslalssv
|.| .||.| .  .    |||||| .    |.   | ....|     ||.. ...|.....||.| .| |. ..|  .|.|.| |               
pldrtrvllsnleglersdyinaseil...pg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............

rstethvervlslqfrdqslkrslVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYlhqRPLHTPIIVHCSSGVGRTGAFALLYAAVQEveagnGIpELPQ
                        .. ..  .|  | ||... .|.|.. .....    . . |..|||| ||||.|.....|   .      |.  |..
........................iqylhipipDhgvpdllehflefvefieeal...dekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.slee

LVRRMRQQRKhMLQEKLHLRFCYEAVV
 ....|..|  . .   .||..||   
aielvrerRp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1277-1507 2.4e-24 80.3 In-house 53-281 (302) alignment 
Range on Protein: 1277-1507
Range on HMM: 53-281/302.0
LKNRHQDVMPYDSNRVVLRSGKDDYINASCVEglSP-YCPPLVATQAPLPGTA---ADFWLMVHEQKVSVIVMLVSEAEMEKqKVARYFPTERGQPMVHG
 ||...||  .|||.| |   .|.|.||| ||   |   .... .| |  ...   ..|| ||...|.  .|.|| | |..|  .  .||.. |.   .|
kknqsedvpildsnlvkleaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeyg

ALSLALSSVRSTETHVeRVLSLQFRDQSLKRSLVH--LHFPTWPELGLPDSPSNLLRFIQEVhahYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEV
.. .    | ..| ..   ...    .    |..    ..  |..   |.. ..| . ...|   . .. .   ....    |.|| |||  | .||...
kmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavavekl

EAGnGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAV
..|   |.  ..|. .|.|| ....      . | |.
qkg.kepnikeivksiRsqRpravdslkQyvslyial
subfamily_ptpA1_pd Subfamily ptpA1 1277-1462 5.8e-24 79.6 In-house 49-248 (418) alignment 
Range on Protein: 1277-1462
Range on HMM: 49-248/418.0
LKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGLspYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP----
 |||. ...| .  || |.  .|    |||||  ..|   |   ...|| ||| | |||| || |... .||||  |.|  . |. ||.| . |      
sknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsi

-----MVHGALSLALSSVRS-TET-HVERVLSLQFRDQslKRSLVHLHFPTWPELGLPDSPS---NLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTG
      | |. |. |  |    |   . | . | |  .   | . . ..  ||.  .||      .||. | . . . .       |||||||.||||||
ygngnevfgtysvelveviqdpereiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

AFAL
.|. 
tfct
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1290-1517 3.2e-22 74.0 In-house 33-265 (290) alignment 
Range on Protein: 1290-1517
Range on HMM: 33-265/290.0
NRVVLRSG----KDDYINASCVEglSPYCPPLVATQAPLPGT-------AADFWLMVHEQKVSVIVMLVSEAEMEKQ--K--VARYFPTERGQPMVHGAL
.||||.      .|||| |. |    |    |..||.|.  .         .|| |... ||  .|||    | ...  .   |.|.|.. |. .  . |
trvvLkgygkrfnddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

SLALSSVRSTETHVERVLSLQFRDQSlKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGN
..   |    .   .| | ..| |.  .  . |  .  | .|  ....  ||  || |.|.       .||.||||  |. |  |.| .  . | .   .
tvkCkskekeddvetRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaets

GIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQR
|  .| ...  .|.|| ......| | |   ..|  . .||..
gsvkledvlkalrkqralaitsalelafvdagivllaievldq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1277-1489 7.6e-22 72.3 In-house 39-246 (281) alignment 
Range on Protein: 1277-1489
Range on HMM: 39-246/281.0
LKNRHQDVMPYDSNRVVLRS-----GKDDYINASCVEglSPYC-PPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV
 |||. ..   |  || |.         ||| |  .   ||.     . || |   | |||| |. ... . ||||.   | ...|.| ||| .    . 
kknrylnipcldisrvqlkvkmpnknstdyihanyir..spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

HGALSLALSSVRSTETHVERVLSLQFRDQslKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEV
   ||..       .. |   | | .  .   | . |  .  ||.  .|.|   .|. .....|.        || ..|||.||||.|..  .  |.| .
fdklsvsyedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrkirar.......stppvihcsagvgrsgtlmaveialqsi

EAGNGIPELPQLVRRMRQQ
 .   .|.. |.| ..|  
hshftlpdikqivshlrvt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1261-1432 9.8e-22 72.2 In-house 17-193 (297) alignment 
Range on Protein: 1261-1432
Range on HMM: 17-193/297.0
EHDARGRSIAIARCYSL--KNRHQDVMPYDSNRVVLRSG--KDDYINASCVEGLS-PYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQ
 ..||| | . |.  |   |||..|.. .|..|| |. .  . |||||  |     .     . .| ||  |  ||| .| || | ||||.    |  ..
ldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEV
| | |.|   .. .  | . .   |  | | .   .  ||.  .| .| . |  | .||. |.|    .| ||  .|
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1278-1511 2.8e-20 67.1 In-house 50-279 (303) alignment 
Range on Protein: 1278-1511
Range on HMM: 50-279/303.0
KNRHQDVMPYDSNRVVLRsgKDDYINASCVEGLSPYcpPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQpMVHGALSLA
|||  ||.  |  .| |      || || .|  |      . || ||. |||||| |. |||| ....|....|..|      || ..   .     |. 
knrfvdvicldhskvkls..dssyihasyleldssk..kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lkfeersir

LSSVRSTETHVERVLSLQFRDQSLKRSLVHLH-FPTWPELGLPDS-PSNLLRFIQEVHAhYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNG
.   .  |     || .    .   .|..|.| . .||   .|    ..... | .. . .| .    || .    ||.||.|.|||. .|   . . . 
vgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqs.vlrkysdstptvymslsgcgragtfalfetahlslhseqa

IPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
  .| . .  .|. | | .|.   . . |  .  ||
sldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_CG42327_pd Subfamily CG42327 1273-1435 3.7e-20 66.8 In-house 26-193 (319) alignment 
Range on Protein: 1273-1435
Range on HMM: 26-193/319.0
RCYSLKNRHQDVMPYDSNRVVLRS----GKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP
     |.|  .|.|    ||||..     || |..|| | |        .|.|..|  ...||| .| ||.  ||| |..  |   .. |.|.||. . .
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

M--VHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFpTWPELGLPDSPSNLLRFIQEVHAH
   ..| . ..|    . . ..   | |.  |... | | |  .  |.| ..| ... |.  . ||.. 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0048076 (Phosphotyrosine protein) phosphatases II 1360-1508 5.1e-20 67.1 In-house 2-140 (145) alignment 
Range on Protein: 1360-1508
Range on HMM: 2-140/145.0
YFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHqrplHTPIIVHCSSGVGRTGA
|.|.|  . .  | |  ||.  .  . .. .||.|    . |.|  .....  ||  | ||... ||.|.. ..... .    . |..|||| ||||||.
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgt

FALLYAAVQeveagNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV
....|   .     .|   |.. ....|.|| .. .   .|||.||.. 
lvaaylmll.....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_egg_pd Subfamily egg 1270-1513 7.2e-19 62.6 In-house 35-272 (307) alignment 
Range on Protein: 1270-1513
Range on HMM: 35-272/307.0
AIARCYSLKNRHQDVMPYDSNRVVL--RSG--KDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMekQKVARYFPTER
|..  .  | | . |   || || |  | |   ||.| |  |.|  |    .. .||||  |  ||| ||....|  |||| |  |   ..   |.|   
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

GQPMVH--GALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIqevhahylhqRPLHTPIIVHCSSGVGRTGAFALL
 ...|   |.| .    | |.   . ||  |.      .   .      . ...   || ..|| .          | | .|..|..  || .....  .
sdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrkl..........rnlskpvvvqdilGvskaatlvai

YAAVQEVEAGNGIP-ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ
  |. ..  |      . . |  .|..|.  ..  |   | |  |.  . .
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
0048179 (Phosphotyrosine protein) phosphatases II 1370-1505 2.1e-17 58.7 In-house 12-139 (144) alignment 
Range on Protein: 1370-1505
Range on HMM: 12-139/144.0
VHGALSLALSSVRSTETHVERVLSLQFR--DQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLhqrpLHTPIIVHCSSGVGRTGAFALLYAAV
  | |  ||.  .  . ..  |..|.     ..|.|  .....  ||  | ||... ||.|.. .....      . |..|||| ||||||.....|  .
ylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk

qeveaGNGiPELPQLVRRMRQQRKHMLQEKLHLRFCYE
      .|   | . ....|..| .. .   .|||..|
.....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1273-1500 7.3e-17 55.9 In-house 50-279 (310) alignment 
Range on Protein: 1273-1500
Range on HMM: 50-279/310.0
RCYSLKNRHQDVMPYDSNRVVLR---SGKDDYINASCVEGlSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTeRGQPM
. |  |||. ||.  |. || |.   |  .||| |  |         .. .| ||  |  ||| |. ...   |..|.  .|  . |.  |.|.  |   
kkymhknrysdvvcldtsrvklkidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvte

VHGALSLALSSVRSTETH--------VERVLSLQFRDQSLKRSLVHL-HFPTWPELGLPDSPSNllrfiqEVHAHYLHQRpLHTPIIVHCSSGVGRTGAF
 .| . ..  |  | |          |   . .. .   ||   | | ..| ||. |.||           |    | |   | | .||||.|..|... 
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch......tvpqrllaqv.rhgpcvvhcsagkdrlyvv

ALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHL
. |  ... .. |. . .. ...  ....|    | .|  
valklkidkldrglkv.daeevktellksraiciqtelqy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1318-1505 2e-16 54.8 In-house 7-197 (198) alignment 
Range on Protein: 1318-1505
Range on HMM: 7-197/198.0
VATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHV--ERVLSLQFRDQSLKRSLVHLHFPTWPE
.||| ||  | |||| || |     |||.  .    .   . |.||       .|.||..  .. .   ..    .|. .       | . |  | .| |
iatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswke

LGLPDSPSnLLRFI---QEVHAHYLHQRplHTPIIVHCSSGVGRTGAFALLYAAVQEVE-AGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYE
   |.    .. |.   .||  .|  ..   .|.||||| | | || |  |   |.  | .   . .| .. .|.|| |  ..    |  | |.
kttpnval.fvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1318-1505 2.2e-16 54.6 In-house 8-198 (199) alignment 
Range on Protein: 1318-1505
Range on HMM: 8-198/199.0
VATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHV--ERVLSLQFRDQSLKRSLVHLHFPTWPE
.||| ||  | |||| || |     |||.  .    .   . |.||       .|.||..  .. .   ..    .|. .       | . |  | .| |
iatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswke

LGLPDSPSnLLRFI---QEVHAHYLHQRplHTPIIVHCSSGVGRTGAFALLYAAVQEVE-AGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYE
   |.    .. |.   .||  .|  ..   .|.||||| | | || |  |   |.  | .   . .| .. .|.|| |  ..    |  | |.
kttpnval.fvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1305-1508 5e-16 53.5 In-house 20-218 (255) alignment 
Range on Protein: 1305-1508
Range on HMM: 20-218/255.0
SCVEGLSPYCPPLVATQAPLpgTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRS
 | |.. |  ..   .   |  | . |. ..  .| .|.|||   || ...|  .|||.|. . ..   .... .   .      ... ... ..   . 
vctehvkPekdkkrknlysl..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkktht

LVHLHFPTWPELGLPDSPSNLLRFIQEVHAhylhqrPlhTPIIVHCSSGVGRTGAFALLYAAVQ----EVEAGNG-IPELPQLVRRMRQQRKHMLQEKLH
. | ..  |.|   |. . ..|  .. |.           ...||||.|.||. ||.|   . |     ..  .    .  .|.. .|..||  ... |.
vkhysykGWieknaPelareilnilkvvrd......s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

LRFCYEAVV
| |.   |.
lafsilmvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1277-1363 8.7e-16 52.6 In-house 49-152 (350) alignment 
Range on Protein: 1277-1363
Range on HMM: 49-152/350.0
LKNRHQDVMPYDSNRVVLR------------SGKDDYINASCVEGL--S-PYCPPL--VATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVAR
 |||.....||. .|| |.               .|||||. ..    |    |    .||||||| |  ||. .. . || ||..| |. |.. .|. |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YFPT
|.. 
YWqe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1278-1467 1.3e-15 51.9 In-house 46-233 (312) alignment 
Range on Protein: 1278-1467
Range on HMM: 46-233/312.0
KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSpYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV-----HG
 ||. ..  .|  |  |   .. || |  |   .     .|.||.||  |.. || ..     . |..|..  |   .|.|.|     |   .     . 
lnrypniqcwdrgrftlagdenfyihanfvkict.kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

ALSLAL-SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAV
     .    .| .    ||| .  .    .  | |  . .||. |.|||    ||..  |.         . |.| |||.||||||..||. . .
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd.......kkpviahcsagvgrtgtlaliesmi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1323-1502 1.7e-15 51.2 In-house 99-279 (302) alignment 
Range on Protein: 1323-1502
Range on HMM: 99-279/302.0
PLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRS-----TETHVERVLSLQFRDQS----LKRSLVHLHFPTW
|   |   .| .... .|...| |.|  | |..|.| |. .. |. .  |  ..   ||.      |. .  .. .......     .|...  |.| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PELGLPDSPSNLLRFIQEVHAHylhqrplHTPIIVHCSSGVGRTGAFALLYAAVQEVeAGNGIPELPQLVRRMRQQRKHMLQEKLHLRF
|. | |. . . |  ..   ..        . ..|||| ||||||..  .   .|   . . . .| ..|  .|| |   .|..  | .
pdhGapkeaytaldilkfcesy.......kknvlvhcsaGvGrtGtlvaikyGiqlc.skkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_eak_pd Subfamily eak 1272-1512 2.4e-15 50.8 In-house 48-306 (332) alignment 
Range on Protein: 1272-1512
Range on HMM: 48-306/332.0
ARCYSLKNRHQDVMPYDSNRVVLRSG---KDDYINASCVEgLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQP
||  ...    ...||| . | | |    .. ||||| .| .|      . | ..       || || |||   ||.|. . |.. .|  .||| .  . 
arleavnrnvvkivpydrylvrltssqlnrlGyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

MVHGALSLALSSVRSTETHVERVLSLQFRDQSlkRSLVHLHFPTWPELGLPDSPSN--LLRFIQE----------------VHAHYLHQRPLHTPIIvHC
. .| | .   .    .    | | |.  ...    . | ..  | |. ||       | . ..|                .  .| |  | ..|||  .
lkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qs

SSGVGRTGAFALLYAAVQEVEAG-NGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE
. |  |.|.| ..   .. ...  .    . .|. .....|.|    .|.  | ||.|. .. 
arGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_hpo-7_pd Subfamily hpo-7 1306-1509 1.4e-13 45.3 In-house 24-225 (263) alignment 
Range on Protein: 1306-1509
Range on HMM: 24-225/263.0
CVEGLSPYCPPLVATQAP-LPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRS
| |.. |  ..   .    |  | . |. ..  .| .|.|||   .| ...|  .|||.|. . ..   .... . | |      ..|  .. ..   . 
ctehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkktht

LVHLHFPTWPELGLPDSPSNLLRFIQEVhahylhqRPLhTPIIVHCSSGVGRTGAFALLYAAVQ----EVEAGNGI-PELPQLVRRMRQQRKHMLQEKLH
. |  .  |.|   |  . . |. .. .       | .  ...||||.|.||. ||..   . |     ..  . .  .  .|.. .|..||  ... ..
vkhysykgWiekndpelareilnilkva.......rns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq

LRFCYEAVVR
| |    |. 
LafsilmvLd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1270-1351 1e-11 38.9 In-house 91-173 (244) alignment 
Range on Protein: 1270-1351
Range on HMM: 91-173/244.0
AIARCYSLKNRHQDVMPYDSNRVVLRSGK--DDYINASCVEGLSPyCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAE
|.    | |||.   .|.| ||| |  |   . ||||| |  |       . || ||  |. ||| |. |..| |.|.| |  |
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1439-1511 9.1e-11 36.1 In-house 224-295 (297) alignment 
Range on Protein: 1439-1511
Range on HMM: 224-295/297.0
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVeAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHV
. |  ....||||.||||.|   |  . .. .   . ||.   ... .|.||  ..|      ..|.||.. .
emprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1402-1509 1.1e-10 35.4 In-house 88-192 (440) alignment 
Range on Protein: 1402-1509
Range on HMM: 88-192/440.0
KRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHylHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIpELPQLVRRMRQQRKHMLQEKLHLR
 |.| . |.  ||. |.|   . .|..||.|     ...    |..||||.|.||||    . . ..|..  . | ..  ..  ||..| .|.|   .  
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes..qekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtpeqya

FCYEAVVR
| .|||. 
fvheavle
subfamily_CG42327_pd Subfamily CG42327 1443-1509 1.5e-09 31.9 In-house 247-313 (319) alignment 
Range on Protein: 1443-1509
Range on HMM: 247-313/319.0
HTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR
. |..|||| ||||||       |....|  .   ..||||  .|..| . ...|    | |  .  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1405-1508 4.3e-09 30.5 In-house 217-341 (350) alignment 
Range on Protein: 1405-1508
Range on HMM: 217-341/350.0
LVHLHFPTWPELGLPDSPSNLLRFIQ-------EVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQ-------------EVEAGNGIP-ELPQLV
. .|..  |..|.|   | ..|. ..       .  |.   .    .||.||||.|||||| .  |   ..             ...  . .   . ..|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RRMRQQRKHMLQEKLHLRFCYEAVV
 ..|.||  | |..    |.|||. 
nelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1279-1361 3.1e-08 27.3 In-house 52-153 (349) alignment 
Range on Protein: 1279-1361
Range on HMM: 52-153/349.0
NRHQDVMPYDSNRVVLRSG------------------KDDYINASCVEgLSPYCP--PLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVA
||..|..||.  ||.|. .                   ||||||  .. |. . .    .||||||| |  ||. ..  ..| ... | .. | . .|. 
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylk.ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

RYF
.|.
iyw
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1285-1352 7.5e-08 26.8 In-house 3-65 (130) alignment 
Range on Protein: 1285-1352
Range on HMM: 3-65/130.0
MPYDSNRVVlrsgKDDYINASCVeGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM
.... .|.      ..||||| | ||.      . ||.||  |. ||| |. |. | |.|.| |  | 
lefevsrlq....gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1279-1361 3.7e-07 23.9 In-house 38-121 (332) alignment 
Range on Protein: 1279-1361
Range on HMM: 38-121/332.0
NRHQDVMPYDSNRVVL--RSGKDDYINASCVEGLSPYCPpLVATQAPLPG-TAADFWLMVHEQKVSVIVMLVSEAEMEKQKvARYF
||   .  .| .|| |  . ||||. ||| |.| |      . .|||.   |   || || |.| |.|...    | .|.| | | 
nriphlycfdhsrvelapqdgkddfynaswvdgyskksa.yifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk.apyd
0038934 (Phosphotyrosine protein) phosphatases II 1404-1494 6.7e-07 24.6 In-house 79-160 (194) alignment 
Range on Protein: 1404-1494
Range on HMM: 79-160/194.0
SLVHLHFPtWPELGLPDSPSNLLRFIQEVHAHYlhQRPLHTPIIVHCSSGVGRTGAFALLYAAVQeveagNGIpELPQLVRRMRQQRKHML
 . .|..| .|. | . | ..||||.. |. ..  ..  .  . |||  |.|||| ..  |         .|.  . . ....|. |....
gieylklp.fpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgm.saeeAialfrekRpgai
gpW gpW 307-348 2.6e-06 13.5 Pfam-A 12-53 (68) alignment 
Range on Protein: 307-348
Range on HMM: 12-53/68.0
AAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQ
||.  |  ||..   || | || | .. |  |...|.....|
aAlhdLlTGkrvvsvQkdgRrveytaasladLkkyiaeleaq
DUF2577 Protein of unknown function (DUF2577) 615-701 5e-06 13.1 Pfam-A 17-100 (100) alignment 
Range on Protein: 615-701
Range on HMM: 17-100/100.0
KRI-LAKVQEMRDQRVSLEQQlrELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQlkVYLEQNLAAQDRVLCALTEANVQYAAVRRV
..| |..| .    ...|...    ..|.... |  ......  .. ... .. ..  .  |..| . |.||.  .| . .|  . .|
sdivlGeVisvsPLkiklddk..lildkeqlylsellkrytreitvegnekesnke..itiedtLkkGdkVlvlreeggqkyivldkv