Gene PTPN5 in Homo sapiens

Synonym: PTPSTEP, STEP, PTPN5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP082_AA protein Get Run
HsapP082_AA_282-555 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 298-559 3.4e-129 424.8 In-house 5-271 (274) alignment
Range on Protein: 298-559
Range on HMM: 5-271/274.0
FLLQAEFFEIPMNFvDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVM
  |..||.|.|.|| |..|.|..|  .||||||||||..|||.|.| ...|..|||||||||.||..|.|.|.|||||...||||||||..||....|||
kdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

ITNIEEMNE-KCTEYWPEEQVA-----YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAP
.|...|.|| ||..|.|... .     |..|||.|.|.....||..| ..||. ..|| .||||.|.|||.|.||.| .||.||.||||....|  ..||
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
..|||||||||||||||.||...|||.|.|||.||..|.||.|||||.||.|||...|....||.|.|
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl

subfamily_PTPRD_pd Subfamily PTPRD 323-552 2.1e-88 292.4 In-house 49-277 (564) alignment
Range on Protein: 323-552
Range on HMM: 49-277/564.0
VRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEE-QVAYD
 .||||. |..  ||||.|.. . | . | ||||..| ||  ..| |||||||. .|..|||||||.... .|||.|..||... || .||||. .  |.
kaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetyg

GVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
....|...  . .|| .| ..||     | |  ... ||||||.  |. | .||.|.|.|.....   |.  ||.||||||.||||.||. ... .....
eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerike

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|..||| ..  .||..|  |.|| |||.|.|...
ektvDiyqyvkalrkqRnamVqteeQYiFiheai

0039614 (Phosphotyrosine protein) phosphatases II 269-557 1.8e-87 288.8 In-house 3-290 (297) alignment
Range on Protein: 269-557
Range on HMM: 3-290/297.0
PREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKV
|..... |. .   .|| .  |.|||... ||..||.|.. ...| ...  |  . ||||| |||..||||.|...|  |. |.||||.|. ||    . 
plrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

YIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRA
.||||||  .||.|||||||......|||.|. .|.. || .|||||.  |... .|. ||.| ..| .| .... . |.| ..|...|.||| ..|. .
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

PPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
  ||.....|.|| ..  |   |..||||||.||||.|||  ....||. || ||.|.. ..||. |.|..|| .||.|.....  . |
ellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0050432 (Phosphotyrosine protein) phosphatases II 282-557 2e-86 285.4 In-house 26-300 (308) alignment
Range on Protein: 282-557
Range on HMM: 26-300/308.0
SRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPK--EYDIPGLVRKNRYKTILPNPHSRVCLtspdpdDPLSSYINANYIRGYG-GEEKVYIATQGPIVS
 .||.  .|.|||||. ||..||.|.........   .  |  . ||||| |||. ||||.|      |. |.||||.|..||  . .. .||||||  .
lsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpn

TVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPE----EQVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPL
||.|||||||......|||.|...|.. ||| .|||.    . . |... .|. .. . .|| .| . |.   . |.| ..|...|.|||...|. . .|
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

LHLVREVEEAAQQegphcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
|.....|..  ..      ||.||||||.||||.|||  ....||..|| ||.... ..||. | ||.|| |||.|.....  | |
ldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0046845 (Phosphotyrosine protein) phosphatases II 300-557 1.6e-84 279.0 In-house 2-275 (284) alignment
Range on Protein: 300-557
Range on HMM: 2-275/284.0
LQAEFFEIPMNFV----DPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYG----GEEKVYIATQGPIVSTVADFWRMVWQEH
|..|| |.....|    . . .  |  . ||||| |||. ||||.|.|.|.|.. |.||||.|..||.      .| .||||||  .||.|||||||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TPIIVMITNIEEMN-EKCTEYWP--EEQVAYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQe
...|||.|...|.. |||  |||  .| . |... .|. .. . .|| .| ..|.    . |.| ..|...|||||...|. . .||...|.|.|. .. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG---VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
 |   ||.||||||.||||.|||  ....||..||   .||.|.. ..||. | ||.|| |||.||....  | |
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0051299 (Phosphotyrosine protein) phosphatases II 294-555 6.3e-83 273.8 In-house 19-285 (288) alignment
Range on Protein: 294-555
Range on HMM: 19-285/288.0
ALDPFLLQAEFFEIPMNFVDP--KEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEH
| .. .|..|| |.. ...|.  . .  |  . ||||. |||. ||||.|...|. .. |.||||.||.||  . | .||||||  .||.|||||||...
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqn

TPIIVMITNIEEMN-EKCTEYWP-EEQVAYDGVEITVQKVIHTEDYRLRLISLK------SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQ
...|||.|...|.. |||  ||| .. . |. . .|  .. . .|| .| . ..       . |.|  .|...|.|||. .|| . .||...|.| .| .
vrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

qegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
   ..  |..||||||.||||.|||  ....||..||.||.|.. ..||. | ||.|| |||.||....  |
...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0047943 (Phosphotyrosine protein) phosphatases II 290-555 5.3e-80 264.1 In-house 4-271 (273) alignment
Range on Protein: 290-555
Range on HMM: 4-271/273.0
LHEKALDPFLLQAEFFEIPMNFVDP--KEYDIPGLVRKNRYKTILPNPHSRVCLtspdpDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMV
| ||.|.. ||..|| ... ....   . .  |    ||||| |||. ||||.|     .|. |.||||.|..||  . | .||||||  .||.||||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmv

WQEHTPIIVMITNIEEM-NEKCTEYWPEE----QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
|......|||.|...|. .|||  |||.|     . |. . .|. .. . .|| .| . |..    |.|  .|...|.|||...|.   .||.....|..
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

AAQQEGPHcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
| ..   .  |..||||||.||||.|||  ....||. || ||.|.. ..||. | ||.|| |||.|.....  |
alealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

DSPc_SM00195 314-555 9.6e-80 263.0 In-house 18-261 (263) alignment
Range on Protein: 314-555
Range on HMM: 18-261/263.0
PKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYW
 .| ...  ..||||| |||. |.|| |.... . . |.|||||||.|.  ..| |||||||  |||.|||||||.|...||||.|. ||  .|||..||
tteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PEE---QVAYDGVEITVQKVIHTE-DYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCF
|||   .  .. .......|.... .. || ..|.  .  |.| ...|....|||...|| . ..|.|.|.|..  ...    .||.||||||.||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtf

IATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
....|....|..|  ||| .. ..||. | ||.|| |||.|.....  |
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 314-555 9.6e-80 263.0 In-house 18-261 (263) alignment
Range on Protein: 314-555
Range on HMM: 18-261/263.0
PKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYW
 .| ...  ..||||| |||. |.|| |.... . . |.|||||||.|.  ..| |||||||  |||.|||||||.|...||||.|. ||  .|||..||
tteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PEE---QVAYDGVEITVQKVIHTE-DYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCF
|||   .  .. .......|.... .. || ..|.  .  |.| ...|....|||...|| . ..|.|.|.|..  ...    .||.||||||.||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtf

IATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
....|....|..|  ||| .. ..||. | ||.|| |||.|.....  |
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0036941 (Phosphotyrosine protein) phosphatases II 292-556 1.6e-79 262.6 In-house 7-277 (297) alignment
Range on Protein: 292-556
Range on HMM: 7-277/297.0
EKALDPFLLQAEFFEIPMNFVDPK--EYDIPGLVRKNRYKTILPNPHSRVCLtspdpDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQ
||.|.. ||. || |.. ......   .  |. . ||||| |||..|.||.|     ||. |.||||.|. ||. . | .||||||  .||.|||||||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvwe

EHTPIIVMITNIEEMNE-KCTEYWP---EEQVAYDGVEITVQKVIH--TEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEA
.....|||.|. .|..  || .|||   .| . |... .|...| .   .|| || . ..   . |.| ..|...|.||| ..|. . .||.....|...
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

AQQEGPHcAPIIVHCSAGIGRTGCFIATSICCQQLR---QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
 ..  ..  |..||||||.||.|.|||  ...|||.    || ||||.. ..||. | |..|| |||.|.....  . 
lkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0040438 (Phosphotyrosine protein) phosphatases II 294-556 2.3e-79 262.2 In-house 14-276 (317) alignment
Range on Protein: 294-556
Range on HMM: 14-276/317.0
ALDPFLLQAEFFEIPMNFVDP-KEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHT
..|  .|. ||.... ...|. ...  |    ||||. |||..||||.|..... |. |.||||.|. |.    | .||||||  .||.|||||||....
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgv

PIIVMITNIEEMN-EKCTEYWP-EEQVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPH
 .|||.|. ||.. ||| .||| .| . |... .|...... ... || . ..   . |.| ..|...|.|||...|.   .||.....|.|| .   ..
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dp

CAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
  |..||||||.||||.|||  ....||..|| ||. .. ..||. |.|..|| |||.|.. ..  | 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

Y_phosphatase Protein-tyrosine phosphatase 324-552 6e-77 253.6 Pfam-A 3-233 (235) alignment
Range on Protein: 324-552
Range on HMM: 3-233/235.0
RKNRYKTILPNPHSRVCL-TSPDPDDplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP---EEQVA
.|||||.|||  ..|| |  |..| |    ||||||..||  |.| .||||||. ||..|||||||||.. .|||.|. ||. .||| .|||   ||.. 
kknRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDGVEITVQ-KVI-HTEDYRLRLISLKSGTEE---RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGPHCAPIIVHCSAGIGRTGCFIATSICC
|. ...... |.  ....| || ..||. .||   | .|....|.|||...|. . .||.|.|.||.      .. .|..||||||.||||.|.| .|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||..|. ||.|.. ..||. | ||.|..|||.|.....
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 324-552 6e-77 253.6 In-house 3-233 (235) alignment
Range on Protein: 324-552
Range on HMM: 3-233/235.0
RKNRYKTILPNPHSRVCL-TSPDPDDplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP---EEQVA
.|||||.|||  ..|| |  |..| |    ||||||..||  |.| .||||||. ||..|||||||||.. .|||.|. ||. .||| .|||   ||.. 
kknRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDGVEITVQ-KVI-HTEDYRLRLISLKSGTEE---RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGPHCAPIIVHCSAGIGRTGCFIATSICC
|. ...... |.  ....| || ..||. .||   | .|....|.|||...|. . .||.|.|.||.      .. .|..||||||.||||.|.| .|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||..|. ||.|.. ..||. | ||.|..|||.|.....
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0045450 (Phosphotyrosine protein) phosphatases II 299-555 1.3e-76 253.6 In-house 28-303 (307) alignment
Range on Protein: 299-555
Range on HMM: 28-303/307.0
LLQAEFFEIPMNFV----DPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYI--------RGYGGeEKVYIATQGPIVSTVADFWRM
.|..|| ...   |    . ...  |    ||||| |||..|.||.|.|.|.... |.||||.|.         ||    . .||||||  .||.|||||
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrm

VWQEHTPIIVMITNIEEMN-EKCTEYWPEE--QVAYDGVEITVQKVIHTEDYRLRLISLK---SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
.|.... .|||.|. .|.. ||| .|||.|  .. |. . .|. .. | ..| .| . ..      |.| ..|...|.|||...|.   .||....||..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

AAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
| ..  |   |..||||||.||||.|||  ....||..||.   ||.|.. ..||. |.|..|. |||.|.....  .
aleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_PTPRB_pd Subfamily PTPRB 324-556 2.9e-76 251.3 In-house 53-286 (293) alignment
Range on Protein: 324-556
Range on HMM: 53-286/293.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE--QVAYD
 ||||. |||  |||| |.. . |.. | |||||||.||   .. .||||||. .|| |||||||.... ||||.|.. |.  .|| ||||..  .|.| 
aknrytnilpydhsrvkLaalk.desgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyG

GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 ...|...  ..||. .| .... ..||| ...| ||||||   |... .||..||.|.||.. .  . .||.||||||.|||| |||     |....| 
dikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCsaGvGRtGtfialdrllqaieeed

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM-SLYE
.|||. . ..||..|  ..|| .|| |.|... .| .
yvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 324-553 4.7e-76 250.9 In-house 48-277 (318) alignment
Range on Protein: 324-553
Range on HMM: 48-277/318.0
RKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQ-VAYDG
.||||  ||.  |.|| |. .  ... | ||||||| ||  ..| |||.|.|.  |. |||||||. .. .|||.|..||   .|.  |||...  .|. 
aknryanilaydhtrvkLq.mlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygk

VEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQQLRQE
. ..... ....|| || ....     |.|  . | .|||||. .|. .  ||.|||.|..| |..| .  ||.||||||.|||| ||| .|  .....|
lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag..pivvhCsaGvGrtGvfiavdillerikae

GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
..||...|  |||. |  |.|| .||.|...|. 
alvDvfqtvkqlreqrnlmvqtedqyefiydvll

0043336 (Phosphotyrosine protein) phosphatases II 296-555 1.2e-75 249.8 In-house 18-276 (278) alignment
Range on Protein: 296-555
Range on HMM: 18-276/278.0
DPFLLQAEFFEIPMNFVDPKEY-DIPGLVRKNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPI
.. ||..||.|.. ...|....   |  . ||||| |||..||||.|..  . |. |.||||.|. ||   .| .||||||  .||.|||||||......
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsll.ggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvtt

IVMITNIEEMN-EKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAP
|||.|. .|.. .|| .|||.. . |... .|..|..| .|| .| . ..     |.|   ||....|||...|.   .||.....| || .   .   |
ivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngp

IIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
..||||||.||||.|||  ....||. || ||.... ..||. |.|..|| .||.|.....  |
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 316-559 9.2e-74 242.8 In-house 11-267 (270) alignment
Range on Protein: 316-559
Range on HMM: 11-267/270.0
EYDIPGLVRK---NRYKTILPNPHSRVCLtSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEY
| |.|  .|.   |||. |||.|..||.| ..  .|. . ||||||.||. ||.| |||..||  .|. .||||.|.|... |||.|..|| . .||  |
esdlpeaargkklnRyadiLPsPatRvrl.eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPEEQVA---YD--GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAP------PLLHLVREVEEAAQQEGPHCaPIIVHCSAGI
||.|.     .    .......  ..| |.|. . |..  ||| | |.|...|||.  | ..        ||...|.| .  ..      |..||||||.
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGv

GRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
||||..||. |... | ... ||.|.   .||.||  ..|. |||.|.......| ...
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

0045098 (Phosphotyrosine protein) phosphatases II 296-557 7.8e-73 240.5 In-house 7-273 (278) alignment
Range on Protein: 296-557
Range on HMM: 7-273/278.0
DPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCltspdpddplsSYINANYIRGYggeEKVYIATQGPIVSTVADFWRMVWQEHTPII
 ..||. ||. .. .. .  ..  .| . ||||| |||..||||.            ||||.||.||    | .||||||  |||||||||.|......|
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvi

VMITNIEEM-NEKCTEYWPEEQ-VAYDGVEITVQKVIHTEDYRLRLISLK------SGTEERGLKHYWFTSWPDQKTPDRA--PPLLHLVREVEEAAQQ-
||.|. .|. .||| .||||.. . |.....|.... ...|| || . .       .. |.||..|.....|||  .|.     ..|.|.....|| .. 
vmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

---------EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLrqEGVVDILKTTCQLRQDRGG-MIQTCEQYQFVHHVMSLYEK
           ..  |..||||||.||||...|  .....|  ||.||.|.. ..||. |.| ..|. |||.|..... .. .
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN6_pd Subfamily PTPN6 323-558 3.1e-71 234.9 In-house 55-299 (306) alignment
Range on Protein: 323-558
Range on HMM: 55-299/306.0
VRKNRYKTILPNPHSRVCLTspDPDDPLSSYINANYIR-GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQVAYD
 .|||||.|||  |.|| |.  .|. | | |||||||.    |..| |||||| . .||.|||||||||.. .|||.|.  |  .|||. |||.|.   .
keknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

GVEITVQKVI--HTEDYRLRLISL---KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEG-PHCAPIIVHCSAGIGRTGCFIATSICCQ
  .|.|..|   ...|| || .|.   |...||| . .| |.||||. .|     .|.....|.. ...    .  ||.||||||||||| || . |  .
yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillk

QLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
.....|.   .|| |.  ..|. | |..|| .||.||..... | ..
liekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 324-553 7e-70 230.6 In-house 58-287 (298) alignment
Range on Protein: 324-553
Range on HMM: 58-287/298.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGEEkVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE-EQVAYDG
.||||  |..  .||| |.. | .|  | |||| .. .| |..  .||||.|...||.||||||..|.   |||.||.||... |...|||. ..  |. 
kkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyge

VEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCQQLRQE
.......  .  |.  | . ...   ..|| ...  ||||||. .|  |  .|.|.|.|.   || |   .|.||.||||.||.| ||| .   .....|
itvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagn..kpvivqCsaGvgRsGtfiaidsvlervkke

GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
 |||....   ||..| |..|| ||| |..... 
qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 324-554 2.3e-69 228.6 In-house 49-277 (288) alignment
Range on Protein: 324-554
Range on HMM: 49-277/288.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQV--AYD
.||||. |||  . || |.  . . . . ||||.|| |... .|.|||||||. .|| |||..|....|  |||.|.. |. ..|| ||||...    | 
kknRyrnilpyDekrvklkkle.eeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyG

GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 |..|.... ..||. || . |.  ..|. ...| ...|||.. |. . |||.|.| |. | |..     |||||||||.|||| |||     .....| 
svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeed

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
..|.. | ..||. |  ..|| .||.|...|.  
yiDvagtvaklRkqRallvqtlkqYefiyevlls

0040439 (Phosphotyrosine protein) phosphatases II 322-555 2.7e-69 228.8 In-house 11-245 (249) alignment
Range on Protein: 322-555
Range on HMM: 11-245/249.0
LVRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP-EEQVAY
 . ||||. |||..||||.|. . |. .||.||||.|| ||    . .||||||  .||.|||||.|...  .|||.|. .|. .||| .||| .. . |
nkdknrypdilpydhsrvkls.ilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

DGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
... .|. .|.. .|| .| . |.     |.|  .|...|.|||...|.  ..|| ....|..| ..  |   |..||||||.||||.|||  ....||.
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqle

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
 |. ||.. . ..||. |.|..|. |||.|.. ..  .
kelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 323-555 3e-69 228.4 In-house 10-242 (245) alignment
Range on Protein: 323-555
Range on HMM: 10-242/245.0
VRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWP-EEQVAYD
. ||||. |||..|.||.|. ||. |. |.||||.|. ||   .| .||||||  .||.|||||.|...  .|||.|. ||.. .|| .||| .| . |.
kdknrysdilpydhtrvkls.pdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

GVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.. .|. .. | .|| .| ....     |.|   ||....|||...||    || ....|..| ..  .   |..||||||.||||.|||  ....||. 
dftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|. |.. ..  .||. |.|..|| .||.|.....  .
elgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 319-555 9.7e-69 226.9 In-house 45-282 (319) alignment
Range on Protein: 319-555
Range on HMM: 45-282/319.0
IPGLVRKNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQ-
 .   .||||. ||.  ..|| |..  .. . | ||||..| ||  |.. .||||.|.  |. |||||||.|.. |.||.|.. |  . |. .|||||. 
keenkkknryqnilaydrtrvvlsel.dgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf

VAYDGVEITVQKVIHTEDYRLRLISLKSGT---EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICC
. |  . .|...  ..|||  | ..|.  .   | | .||. .|.|||.. |..|  ||.|....... ..  ..  ||.||||||.|||| ||. ..  
eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek..tqsgPivvhCsaGvGRtGtfivldaml

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.....|||.|. .|  .||  |  |.|. |||.|.....  .
ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea

subfamily_PTPRK_pd Subfamily PTPRK 324-552 3.1e-68 224.9 In-house 45-273 (314) alignment
Range on Protein: 324-552
Range on HMM: 45-273/314.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQVAYDGV
.|||.. ||.  .||| |.. | .|| | ||||..| .|    . .|.||||. .||.||||.|..|..  |||.|.. |    ||..||||.   |. .
eknrsgdilaydrsrvflitid.gdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

EITVQKVIHTEDYRLRLISLKS----GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.... ..   ...  |. ...       | | .... |..||| ..|  |  ||.|||.|..  ..   .  .|.|||||| ||||.||| .| .. ...
kvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|||||. ..  .||. .  |..| |||.|.. |.
egvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 323-555 3.4e-68 225.0 In-house 47-282 (305) alignment
Range on Protein: 323-555
Range on HMM: 47-282/305.0
VRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQVA---
..|||.| | . ...|. ||  . .|  | ||||.|. || . .| ||..|||. .|||||||....|..  |||.|.. |. ..||  ||||..     
kaknrlkeitlldddriiltekesld.dsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke

YDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQ
.. ......   ...||  | ...       |.| . .| .|.|||.  |. |  ||.|...|... ...  .  |..||||||.|||| ||| .|  ..
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd..kgvpllVhCsagvgRtGvfiavdialer

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|..|.|||. . . |||. | .|.|| .||.|.| .. ..
lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 324-555 7.2e-68 223.5 In-house 11-241 (250) alignment
Range on Protein: 324-555
Range on HMM: 11-241/250.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGEeKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWP-EEQVAYDGV
 ||||  |..  .||| | . .  |  | |||| .. || .. | .||||||...|. ||||||..|..  |||.||..|.......||| |.   | .|
eknryadiialdssrvvLekek.gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdv

EITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 ... .  .  ||  | . | .   ..|| .... |..|||.  |. |   |.|...|.   ||   . ||.||.||||.||.|.||| .   ..|..| 
tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa..gnaPvivqCsaGvgrsGafiaidavlerlkkek

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|||. |   .||.|| ..... ||| ||....  .
vvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_PTPN12_pd Subfamily PTPN12 323-560 4.4e-67 221.0 In-house 41-282 (290) alignment
Range on Protein: 323-560
Range on HMM: 41-282/290.0
VRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEE---QVA
|.||||| |||  .||| |.  . ..  |.|||||.|.|  | .. |||.|||.  |. |||||.|. .. |.||. .. |..  ||  |||||   .. 
vkknrykDilPydksrvelskieeee.gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

YDGVEITVQKV-IHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
.. .|.|...    ..|. .| . ..   |.| .. . .|.|||. .| .| .||.|...|.|  .    . ||..||||||.||||  ||  .  ..|.
fgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellk

QEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHH-VMSLYEKQLS
.| .   .|. .   .||..|  ..|| |||..|.. |..| .|.|.
aekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_Ptp69D_pd Subfamily Ptp69D 324-555 7.2e-67 220.7 In-house 50-285 (307) alignment
Range on Protein: 324-555
Range on HMM: 50-285/307.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWP-EEQVAYDG
 ||||. | .  . || |.     .  |.||||..|.||  |.| .|| |.|. .|. |||||... .  .|||..|..|.|. ||  ||| |..| |. 
lknRyedikafDktRvkLkkin.gkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygd

VEITVQKVIHTEDYRLRLISLKSGT-------EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICCQ
. ... .  ...||  | ...           ..| .  | .|.|.| | |. |  ||.|...|.|  ...    .||.|||||| ||.| |.| ..  |
ilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllq

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
||..|  ||| .|...||..|  ..|  |||.|... .  |
qlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_PTPN9_pd Subfamily PTPN9 319-556 1.1e-65 216.6 In-house 39-290 (297) alignment
Range on Protein: 319-556
Range on HMM: 39-290/297.0
IPGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWP-EEQ
... ..||||. .|   ..|| |.. | .|. | |||||.. ||  ..| .||||||.  || |||||||.... .|||.| ..|.   ||..||| ||.
lranleknrytdvlcydetrvvlakvd.edeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

VAYDGVEITVQKV--IHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAA----------QQEGPHCAPIIVHCSAGIGR
 . . ....|..|   ..|||. | . .|     |.| . |. |.||||  .|. |  ||.....| |.           ..  |.  ||.|||||||||
ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
|| ||.  || ..|...|.||. .|  .||. |  .||| |||.| .  .  | 
tGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

0037934 (Phosphotyrosine protein) phosphatases II 323-554 1.4e-65 216.6 In-house 11-240 (243) alignment
Range on Protein: 323-554
Range on HMM: 11-240/243.0
VRKNRYKTILPNPHSRVCLtspdpDDplSSYINANYIRGYGGeekvYIATQGPIVSTVAD----FWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQv
. ||||..|||..||||.|     ..  |.|||||.|.....    .||||||  .||.|    ||||.|.... .|||.|. .|.  ||| .|||.|. 
lsknrysdilpydhsrvkl.....eg..sdyinanliyvtpr....liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev.

AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQ-----EGPHCAPIIVHCSAGIGRTGCFIAT
 |.....|. .. |..|| .| ..|.    . ..|   ||....|||...||   .|| ...|| |  ..       ..  |..||||||.||||..|| 
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

SICCQQLrqeGvVDILKTTCQLRQDRGG-MIQTCEQYQFVHHVMSL
 .....|   | ||.... ..||. |.| ..|| .||.|.....  
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 324-552 7.1e-65 214.3 In-house 49-283 (563) alignment
Range on Protein: 324-552
Range on HMM: 49-283/563.0
RKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQV-AYDG
|||||  |..  .||| |..    .    ||||||| ||   .| .||||||. .|. |||||.|.... |||||||  |....||  |||....  |. 
rKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetyga

VEITVQKVIHTEDYRLRLISLKS-----GTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICC
...| ..  ..  |  | ...|      . .   |.  ..| .|.|||. .|. . | |  |.  . | ..|     ||.||||||.|||| .|. .   
lqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankae...aGPivvHcsaGvgrtGtyivldtll

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.|..|| .|.....  ..|  |  ..|| |||.|.| ..
kqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

subfamily_PTPRA_pd Subfamily PTPRA 323-555 7.2e-65 214.0 In-house 59-294 (330) alignment
Range on Protein: 323-555
Range on HMM: 59-294/330.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE-QVAYD
 .|||.  |||. .||| |.  .   . | |||| .| ||  | . .||.|||   || |||||.|. ..  |||.|...|  .|||. |||.|  |.| 
keknrvvnilPydfsrvilsvke.GveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyG

GVEITVQKVIHTEDYRLRLISLK---SGT---EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcaPIIVHCSAGIGRTGCFIATSICCQ
 . ..|...  ..|| .| . ..    .|   ..| .. . ||||||   |  .  .|.|...|..  ||..    ||.||||||.|||| ||. .   .
nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag...pivvhcsaGvGrtGtfivldavle

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
... |..||. ..  .||. |  |.|| |||.|...|.  |
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-552 1e-61 203.6 In-house 50-275 (315) alignment
Range on Protein: 323-552
Range on HMM: 50-275/315.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTE-YWPEEQVAYDG
..||||  |..  .||| |   .  || | |.|||.| ||   .. |||.||| |..| ||||.|..|.   |||.||. | ... .| |||...| |  
kqknryiniiaydksrvqlplle.ndphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGk

VEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
. .| ..  . ..|  | .|  .| . | .  . .||||| . |  . ||..|.| |    ...    ..|.||||||.|||| ||. .   .|.  | .
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaena

VDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.|. .   ..|| | .|.|. |||||.. ..
idvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 324-552 1.9e-61 202.8 In-house 53-280 (297) alignment
Range on Protein: 324-552
Range on HMM: 53-280/297.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeekVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVA-YDGV
 |.||| |||   ||| | . . ||| | |.|| ...|.      .|.|| |  .||||||.||..|.. .|||... .| ..||. ||... |. .  |
eksRYkniLPydssRvkLaivn.ddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

EITVQKVIHTEDYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPD--RAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQQLRQ
 .... | . | .  | .... |    .| .| | |..|||.. .   .|. ||.|. ||..  .|.     |..|||.||.|||| ...   .  . ..
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvaeakr

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|  |||...  .|||.|  ..|| |||.||. ..
ekevdifglvkklrqerpylvqtkeqykfvyvav

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 323-553 3.4e-61 201.8 In-house 42-273 (281) alignment
Range on Protein: 323-553
Range on HMM: 42-273/281.0
VRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQ--VAY
| ||||. |    ..|| .| |. ..  . |||||.. || ||.. |||||||. .....||.|||...  .|||.|. ||. . ||  |||...  . |
vlknrYsnivaYDatrvkvt.pneenkntDYinanfvpgykgeke.yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselky

DGVEITVQKVIHTEDYRLRLISL-KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCQQL-R
  | .. ..  ... |  | ..| ....|.| ...  .|.|||.  |. .  ||.  .||... ...    ||...|||||.||||..||    .... .
gdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihCsaGvGrtGtyialDrlvkavea

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
..  .|.  .  .||..|  |.||  ||.||.... 
eleeldvkavvaelrkernlmvqtvvqyefvykavl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 309-552 5.9e-61 201.5 In-house 48-287 (319) alignment
Range on Protein: 309-552
Range on HMM: 48-287/319.0
MNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemNEKC
.|  | .  ...    |||.  ||.  ...| |   .  .  | |||| .. ||  ..| |||.|||   |.||||||.|. ..  ||..|     ..||
vnladqtfanldqnkdknriinilafdknvvklerliGee.fsdyinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncstivllt.....kdkc

TEYWPEEQV-AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTG
..||| . |  ..  .. |. |  |..| .| | |      .. | .. . |  |||.  || . .|. ||. |.   ..|  | |.|.||||||.||||
sqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.nhranivvhcsaGvGrtG

CFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
 .|.  .  .....|  ||. ..  .|||.|  ..|   ||.|..  .
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 317-552 2.7e-60 199.3 In-house 20-251 (284) alignment
Range on Protein: 317-552
Range on HMM: 20-251/284.0
YDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemNEKCTEYWPEEQ
 ...    |||.  ||.  ...| |   .  .  | |||| .| ||  ..| |||||||   |.||||||.|. ..  ||..|     ..||..||| . 
anldqnkdknrighilafdknvvklerliGee.fsdyinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplki

V-AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSIC
|  ..  .. |. |  .|.| .| | |      .. | .. . |  |||.  || . .|. ||. |.   ..|  | |.|.||||||.|||| .|.  . 
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvyivldvl

CQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
 .....|  ||. ..  .|||.|  ..|   ||.|..  .
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 324-561 3.2e-59 195.2 In-house 48-288 (290) alignment
Range on Protein: 324-561
Range on HMM: 48-288/290.0
RKNRYKTILPNPHSRVCLT-SPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV-AYD
..||...|...   |. |   ..  |   .|||| || ||  |.| |||||||. .|..|||...|||...||||.||| |... ||  |||.... ||.
llnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkayg

GVEITVQKVIHTEDYRLRLISLKSGTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphCAPIIVHCSAGIGRTGCFIATSICCQQLR
 ..|....  ....|. | ...|. ..   .. ...| .|.|...         |....|...   ..|    .|.||||...||.. |.|. .  .. .
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkck

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSH
.|||.|...   ..|. . |..|| .|||......  | .... 
tegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 322-552 8.2e-59 194.0 In-house 44-273 (315) alignment
Range on Protein: 322-552
Range on HMM: 44-273/315.0
LVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE---EQV
  .||||| |||  ..|| |   | |.| | |||| ||...  ..| |||.|||  ..| ||||||.||..  |||.|. .| .  ||  |||.   . |
nfkknryknilPldsarvklevid.dsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

AYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAaqqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
 .  ..... ..  . |   | . .. . | | .  . || |||. .. ..  ||.|..||      .|..  ...||||||.|||| .|.   . .|..
efGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkkefsllvhcsaGvGrtGvvisidevvaqik

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.. .||....  .||..|  ..|| |.| |.. ..
rtrsvdvfnfvknlrakrpylvqteeeyafiydav

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 320-554 2.5e-58 192.8 In-house 46-286 (325) alignment
Range on Protein: 320-554
Range on HMM: 46-286/325.0
PGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMV--WQehTPIIVMITNIEEMNEKCTEYWPEE--
|  . |||.| ...  .|||.| . . ||| | ||||.|.| . .  .|..|.| |  .|. |.||.|  |.  ....|..  ... ...|. |||.|  
penkaknrfknvvaldksrvvletkk.ddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWr..csvvvvlneldlgkdrcavywpkemg

-QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWP---DQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIAT
  . . |.|. .. . .  ||  | . .|   . | | .| . . ||.    || |    ..|.|| .|.|  . .    .||.||||||.|||| ||. 
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

SICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
    ... .|  |||..   .||.||  |..| .|| .... .  
ysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 323-552 3.7e-57 188.6 In-house 44-272 (515) alignment
Range on Protein: 323-552
Range on HMM: 44-272/515.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE---EQVA
 .||||| |||   .|| |   . |.| | |.|| ||...   .| |||.|||  ..| ||||.|.||..  |.|.|. .| .  ||..|||.   . | 
fkknryknilPydsvrvklevin.dnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.  ... .  .    .   | . .  | . | .  . || |||. .| ..  || |..||    .|      |.|.|||||.|||| .|.   .  . ..
fGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvahakt

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
  .||....  ..||.|  ..|| ||| |.. ..
trmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 325-550 3.4e-56 185.0 In-house 10-234 (239) alignment
Range on Protein: 325-550
Range on HMM: 10-234/239.0
KNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVAYDGVE
||||  |.   |||| |     .|| | ||||.|.| | |  | |||||| .  .  |||||.|||.  .|||.|  ||  ..|| .|||.    |  . 
knryanivtydhsrvvlekl.sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ITVQKVIHTEDYRLRL--ISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
.|..|     || .|   .|    |||| . .| || |||.  |. |  .| | |..    ..  | . | ..|||||.||||.|.      .| ...  
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit...kdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..    .|.||  |.|| ||| |.| 
vdifnyvkairedrphmvqtseqyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 325-550 3.5e-56 185.0 In-house 11-235 (239) alignment
Range on Protein: 325-550
Range on HMM: 11-235/239.0
KNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVAYDGVE
||||  |.   |||| |     .|| | ||||.|.| | |  | |||||| .  .  |||||.|||.  .|||.|  ||  ..|| .|||.    |  . 
knryanivtydhsrvvlekl.sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ITVQKVIHTEDYRLRL--ISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
.|..|     || .|   .|    |||| . .| || |||.  |. |  .| | |..    ..  | . | ..|||||.||||.|.      .| ...  
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit...kdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..    .|.||  |.|| ||| |.| 
vdifnyvkairedrphmvqtseqyvfihl

subfamily_PTPN3_pd Subfamily PTPN3 322-557 7.9e-56 184.0 In-house 41-277 (280) alignment
Range on Protein: 322-557
Range on HMM: 41-277/280.0
LVRKNRYKTILPNPHSRVCLTSPDPDdplssYINANYIR-GYGGEEKV--YIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPE--E
 . ||||. |||  . || |.. . |     ||||||.     ... |  |||||||. .|..|||.|||.... .|||.|. .|.   || .||||  .
nlsknryrdilpydatrvklkesetd.....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

QVAYDGVEITVQKVIHTEDYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICC
.. | . .....|  .|. | || . ||  .  ||| . .  ...|||.. || .  .|..|..|... .    .  |..||||||||||| .|.  .. 
eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg...keePvvvhCsaGigrtGvlilletal

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVH-HVMSLYEK
. . ..  | .|.   ..|. |. ..|| .||.||   .. .||.
alieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_PTPN13_pd Subfamily PTPN13 324-552 6.3e-55 181.4 In-house 39-265 (273) alignment
Range on Protein: 324-552
Range on HMM: 39-265/273.0
RKNRYKTILPNPHSRVCLTSPDPddplssYINANYIRGYGGEE-KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQ----V
.||||. .||  ..|| | .  .      ||||..|.   |..  .|||.|||.  ||.|||.|||. .. .|.|.|.  |. . ||  ||||..    .
dknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk

AYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegpHCAPIIVHCSAGIGRTGCFIATSICCQQ
... .|... || . ... .| . .|    .| | . |  |..||| ..|  | .||..|.|| . ..    . .||.|||||||||.| .|.  .  . 
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlgl

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
. ..  .|. ..  .||. | |..|| .|| ||....
ierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 325-555 4.2e-54 178.5 In-house 50-277 (287) alignment
Range on Protein: 325-555
Range on HMM: 50-277/287.0
KNRYKTILPNPHSRVCLTspdpdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQ-VAYDGV
|||.. ||.    || |      .    |||| .| ||  |.| .|....|...|. .||....... ..|||...  |. .|.| .|||||. | .   
knRltqilvpdnyrvllk.....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGey

EITVQKVIHTEDYRLRLISLKSG---TEERGLKHYWFTSWPDQK-TPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.|.. .  ....|  | . .|     .... .| | .|.|...   .. .  || . . .    .|  .  ..|.||||...||.. |.|  .  .. ..
niellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk...tqrkrgntsivvhCsdtvGrsamfcaaattinkckt

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|||.|...   . |. . |..|| |||.|. ...  |
eGviDvfqvlksqriqkpgsvqtveqykfindivley

subfamily_PTPN23_pd Subfamily PTPN23 323-554 9.8e-54 177.1 In-house 44-278 (288) alignment
Range on Protein: 323-554
Range on HMM: 44-278/288.0
VRKNRYKTILPNPHSRVCLTsPDPDDplssYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEK-CTEYWPEE---QVA
. |||.. |||  |.||.|     ||    |||| ....       .||||.|. ||..|||.||.......|||... ||.... . .||||.    | 
seknrsrdilPyDhnRvklr.gskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YDGVEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE-AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQ
.. ...|...| .|| .  | ..|.     . . ..|  .||||.   |.    ||... |||.   ... .  .|..||||||.|||| |       ..
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

L-RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
| ...|..||..   .||..|  |.|. ||..|. ...  
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 325-551 1.6e-53 176.3 In-house 6-234 (237) alignment
Range on Protein: 325-551
Range on HMM: 6-234/237.0
KNRYKTILPNPHSRVCLTSPDPDdplSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE--QVAYDG
||||  |    |||| |  .  .   | ||||.|..|. |  | |||.|||. |.  |||.|||||.  .|||.| . |  ..|| .|||.     ||  
knrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

VEITVQKVIHTEDYRLRLISLKSGTEERG---LKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
. ....|  .  || .| . |   .. ..   .. | ||||||.  |...  || . ... . ..   ....| |.|||||.|||| |.      .| ..
ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsp.hvsesgpwiihcsagvgrtgiflvidamlrqake

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
. |||| .    . .||  .||| .|| |.|..
kkvvdiynyvysieedrpyiiqtkdqyvfihqt

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 323-557 1.2e-51 170.3 In-house 39-278 (287) alignment
Range on Protein: 323-557
Range on HMM: 39-278/287.0
VRKNRYKTILPNPHSRVCLtSPDPDDpLSSYINANYIRGYGGEEkVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPEEQVAY--
|.||||  .||  ..|| | | ...   |.||||||. .|  .|  .||.|||| .|| ||||.|.....  ....  ..||   || .|||| .|    
vkknryadvlPiddtrvll.saegel.Gsdyinanyvasytdde.afiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

DGVEITV-QKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREV--EEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQ
 |  ... .. |   .|  | . |    . | | .| . . ||||.  .  |  |. .| .|     .....    |..||...||||.| ..|| .. .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
.| . | ||. ..  .||. | ...|.  |....   .  | |
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 324-552 3.4e-51 168.8 In-house 35-262 (283) alignment
Range on Protein: 324-552
Range on HMM: 35-262/283.0
RKNRYKTILPNPHSRVCLTSPDPddplsSYINANYIR--GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIE-EMNEKCTEYWPEE-QVAY
||||.. |.|    || | |  .     .|||| .|       ..| ||..|.|.  || |||.||..|.   |||.|..  ....||. |||..  . |
rknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy

DGVEITVQKVIHTEDYRLRLISLKSG---TEERGLKHYWFTSWpdqKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL
    .|..|    . .  ... |.      ..  | || .  |      .  ...  ||.     ..|   . .||.||||.|||||. ||| |   ...
GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda

RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
. | |||. ..   .|..| ...|| .||..||...
ltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_PTPN14_pd Subfamily PTPN14 319-555 6e-50 164.9 In-house 46-295 (300) alignment
Range on Protein: 319-555
Range on HMM: 46-295/300.0
IPGLVRKNRYKTILPNPHSRVCLTSPDPDdpLSSYINANYIRG-YGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE-
 |  ..|||.| .||  ..|| |..   .   . ||||  |.   ||.|. ||..|||.  || |||.|||.... .|||.|.. |. .||. .|.|.. 
lpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

----QVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHC------APIIVHCSAGIGRT
    .| ..  ..| . . ... .  . . ||     ||| . |  .| |||.. |.   . |. ..||.   ..   .        |..||||||.|||
skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrt

GCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|  | . .  . | .. ..|| |.  .||. |  ..||  ||.||..|.  |
GvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_PTPRN_pd Subfamily PTPRN 321-551 1.4e-49 163.4 In-house 55-287 (297) alignment
Range on Protein: 321-551
Range on HMM: 55-287/297.0
GLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEEQV-A
  |.|||.|..||  |||| |..    .  | ||||  |      . .|||||||. |||||||.|||.. . .||..|..||   ..|..|||.|    
knvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev

YDGVEIT-VQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqeGpHCAPIIVHCSAGIGRTGCFIATSICCQQ
|.  |.  | . | ..|| .| . ||    .| | .  . | |||.. .|  | .||.. | |. . .  |  ..||.||||.| ||||..|.  . ...
yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G.rscpivvhcsdGaGrtGvyilidlvlnr

LRQ-EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
| .    .||  |   ||..| |...| .|..|.  .
llkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 324-551 1.8e-49 163.4 In-house 50-274 (439) alignment
Range on Protein: 324-551
Range on HMM: 50-274/439.0
RKNRYKTILPNPHSRVCLTSpDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEkcteYWPE-EQVAYDGV
 ||||| . .  |.|| |    |  | | |||||||.||  ..|.|||||||   |. ||||.|....|  |||.||. |       |||  ..| |  .
tknrykdvgafdhtrvtlqe.ipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcygdi

EITVQKVIHTEDYRLRLISL----KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
 . |.. |   .| .| . .     ..  || . .. ...|||.. | .|  .|...| .. | ..|   . |..||||||.||||  ||  |. .||. 
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke..eygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
|  |||      ||..|  |.|.  || |..  
enkvdikgivkvlrkqrkqmvqalcqyvfiyna

subfamily_PTPN1_pd Subfamily PTPN1 324-550 7.2e-48 157.8 In-house 34-265 (290) alignment
Range on Protein: 324-550
Range on HMM: 34-265/290.0
RKNRYKTILPNPHSRVCLTSPDPddplsSYINANYIRgYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPE----EQVA
 .|||. . |  |||. | . |       ||||. .      .. || ||||...||. ||.|||....  .||. .. |. . ||..|||.    ... 
nlnryrdvspydhsrikleradn.....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

YDGVEITVQKVI--HTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQ
.. ....|. .   ... |..||. |.     | | . |. .|.|||   |.    .|... .| |.     ..  | ..||||||||.| |.    |  
ledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdvGpavihcsaGiGrsGtfclvdtclv

QLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHH
.. ...    ||| |. ..||. | |.||| .| .| . 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsyl

0041856 (Phosphotyrosine protein) phosphatases II 324-555 6.5e-46 151.5 In-house 3-170 (182) alignment
Range on Protein: 324-555
Range on HMM: 3-170/182.0
RKNRYKTILPNPHSRvcltspdpddpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemnekCTEYWPEEQvaydgve
 ||||. |||..|||            ..|||||...|.    . .||||||  ||||||.||.....  .||..|        .  ||||.        
dknrysdilpydhsr...........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

itvqkvihtedyrlrlislksgteERGLKHYWFTSWPDQKTPDrAPPLLHLVREVEEaaqqegpHCAPIIVHCSAGIGRTGCFIATSICCQQlrqeGvVD
                        ||   .|....|||  .||  . ||....||.|       .  |..||||||.||||...|  .....    | |.
........................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
. .. ...|. | ||..| .||.|.. .. ..
leeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 298-550 7.1e-46 151.3 In-house 20-230 (392) alignment
Range on Protein: 298-550
Range on HMM: 20-230/392.0
FLLQAEFFEIPMNFVDPKEYD-IPGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIV
 |.  ||...|   . |.     .  ..||||| |||   .|| |   | | | | |.|| ||...   || |||.||| .... ||||||.||..  |.
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttia

MITNIEEMNekcteywpeeqvaydgveitvqkvihtedyrlrlislkSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHC
|.|...| .                                       | . |    . || |||.  | ..  ||....||.    . | .  |.|.||
mvtklkegd......................................kgddartvaqfhftewPdkdvpkhtssllkfikevk...adfGqythpliihc

SAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||.||||  |.      . ..  .||...   ..|. |  |.|| ||| |.. 
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyg

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 325-555 1e-45 150.8 In-house 43-292 (301) alignment
Range on Protein: 325-555
Range on HMM: 43-292/301.0
KNRYKTILPNPHSRVCLTSPDP-DDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE---QVAY
 ||.| | . .. |. |.     |    .||||.|| ||  |.| .||.|||. .|..||||..|||..  |||.|| .|  ..||..|||.    .  .
lnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseef

DGVEITVQKVIHTEDYRLRLIS-----------------LKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGR
  ...|...     |. .| ..                  ||  . . .  .  |.||..         |. . .|  . |.  .  .|..||||....|
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk..igggpvvVHCSdtVsr

TGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.| ... ||   | . |||||. . |  .|. . |...| ||| ... |.. |
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

0051429 (Phosphotyrosine protein) phosphatases II 349-555 1.9e-45 151.0 In-house 2-224 (272) alignment
Range on Protein: 349-555
Range on HMM: 2-224/272.0
PLSSYINANYIRGYgGE---EKVYIATQGPIVSTVADFWRMvWQEHTPIIVMITNIEEMN-EKCTEYWP-------------EEQVAYDGVEITVQKVIH
|||.||||... || |    ........||   |.|||||. ....   ||.... ||.. .||  |||             .... |  . .|......
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TEDYRLRLISLK---SGTEERGLKHYWFTSWPDQKTPDRAppLLHLVREVEEaaqqegphCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVD-----
..|| || . |.   | .| | . |...|.|||  .|. |  ||.|.... .          |..||||||..|||...|  .. ...  | .||     
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
   ....  .||. | |..|| |||.|.....  .
nlyleeaveelraqrpgavqteeqylflyeallel

subfamily_CG7180_pd Subfamily CG7180 324-553 3e-45 149.1 In-house 44-287 (296) alignment
Range on Protein: 324-553
Range on HMM: 44-287/296.0
RKNRYKTILPNPHSRVCLTSPDPDDPlSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEE-QVAYDGV
 |||. ...|  . || |.. | ..  | |||| |. ..   .| || |..|  .|| .|||.|..|..  .|..|.  ...... .|||.. .  |  .
eknrdvkvvPyDynRvvLekldGeek.sdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygei

EITVQKVI---HTEDYRLRLISL---------KSGTEERGLKHYWFTSWPD-QKTPDRAPPLLHLVREVEEAAQQE--GPHCAPIIVHCSAGIGRTGCFI
.. . ..    . . . ..|            .  .|.| .|.. .| |.  .| |  .  |..|.| |.   ..    |. .|..|..| | .|.| ..
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

ATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
|  .. .....|. ||. .   .||..| ..... |.|...  |..
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 307-552 4.4e-42 138.7 In-house 41-279 (290) alignment
Range on Protein: 307-552
Range on HMM: 41-279/290.0
IPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDplssYINANYIRGYggeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMN
.| .... | .|    ..||||| .  |  .|| |    . |    |. |||..|    . ..| |||.. .|| |.|||| ||..  |||. . ||. .
lpvqylerkifdkntefkknrykdvvcndktrvilkdGydGd....yvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

EKCTEYWPEEQV-AYDGVEITVQKVIHT-ED--YRLRLI---SLKSGTeERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGphcaPIIVHCSA
 || .|.||..  .    ||||    .. .|    ....     .||  |  |||.   ||||.  .  .  || ..| . .|.   |    |..|||||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrkas...G....pvvvhcsa

GIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|||||| |.|  .. | | .   .|.|..   ||. | . .|   ||  . ...
GiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

0046846 (Phosphotyrosine protein) phosphatases II 345-557 5.1e-42 138.9 In-house 6-174 (176) alignment
Range on Protein: 345-557
Range on HMM: 6-174/176.0
DPDDPLSSYINANYIRGYggeekVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEeqvaY----Dgveitvqkvihtedyrlrl
. .|. ..|||||.| |.      .||||||...|.|||..|.....  ..|..|.  |..  ||. ||||    .                        
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...................

islksgteerglkHYWFTSWPDQKTPDRaPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIAtsicCQQLRQEGVVDILKTTCQLRQDRG-GM
             .|... |||  .||    ||.|.....|| ..      |..|||||||||||...|    .  |. |  ...... ...|. |  |.
.............qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplga

IQTCEQYQFVHHVMSLYEK
.|| |||.|..... |. |
vqtpeQyrflyefellllk

0036282 (Phosphotyrosine protein) phosphatases II 351-550 2.1e-41 136.9 In-house 2-164 (174) alignment
Range on Protein: 351-550
Range on HMM: 2-164/174.0
SSYINANYIRGYGGEEkVYIATQGPIVstvadFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEeqvaydgveitvqkvihtedyrlrlislKSGTEER
|.||||... ..   .  .||.|||       ||.|.....  ..|| .. .|.. .||  ||||                            ..  .||
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredler

GLKHYWFTSWPDQKTPDRAPpLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRqEGVVDILKTTCQLRQDRGGMIQTCEQYQFVH
   .|... |||  .|| .  ||..|..|||| ..  ..  |..||||||.||||...|  .....|. |..||.|..  .||. |.||.|| .||.|..
lgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

H
 
y

0049772 (Phosphotyrosine protein) phosphatases II 316-557 2.1e-40 134.8 In-house 40-281 (314) alignment
Range on Protein: 316-557
Range on HMM: 40-281/314.0
EYDIPGLVRKNRYKTILPNPhSRVCLTSPDPDDplSSYINANYIRGYggeeKVYIATQGPIVSTVADF----------WRMV--WQEHTPIIVM------
 .|..    ||||. ||| . .||.| . . ..  |.||||.|..|.    . .||||||   || ||          ||||  .. .. .|||      
vadlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------ITNIEEM-NEKCTEYWPEEQvaydgveitvqkvihtedyrlRL------IslksgtEERGLKHYWFtSWPDqKTPDRAPPLLHLV
               .... .  || . ..... .                     .              |..|.|....  .||  ...    .....
adelsrLdaAlgKtpllildgngneptaadlellk.....................eelydpelf......erlgikylri.pvpD.gsaplledfdefl

REVEEAaqqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLrqeGVvDILKTTCQLRQDRG-----GMIQTCEQYQFVHHVMSLYEK
. .|||     .   |..|||.||.||||.|... ... .|   || .. ..  ..|. |      |.|.. |||.|.....  | |
efieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 320-551 1.2e-37 124.4 In-house 31-290 (297) alignment
Range on Protein: 320-551
Range on HMM: 31-290/297.0
PGLVRKNRYKTILPNPHSRVCLTSPDPDdplSSYINANYIRGYGGEEK-VYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE-Q
.. .|||||. ||    .|| |    ..   . ||||.|.     |..  || .|||. .|| |||..|...   .|||.....|   .||. |||.  |
nsslrknryrdilatddtrvkllrvite...rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

VAYDGVEITVQKVIHTED-Y-R--LRLISLKSGTEERGLKHYWFTSWPDQKTP------DRA-----------PPLLHLVR-------EVEEAAQQEGPH
      .. |. . .| | . |  |  . |   .|.| ..|  | ||||   |      .|            | .| ||           |. . | | 
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

CAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
 |...||||||.||.|  . . .  ..||.. . |.     .||. |  ..|| ||.......
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

0043147 (Phosphotyrosine protein) phosphatases II 348-550 1.4e-37 124.4 In-house 2-155 (172) alignment
Range on Protein: 348-550
Range on HMM: 2-155/172.0
DPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIeemnekcteywpeeqvaydgveitvqkvihtedyrlrliSLKSGTE
|. | ||||.|. .|    . .||||||  .|.||||||.....  .||..|.                                         .    .
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.......................................lydpell

ERGLKHYWFTSWPDQKTPdRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCqqlrqeG-VvDILKTTCQLRQDRGGMIQTCEQYQ
||   .|....|||. .|  .  ||.... ..|.....     |..||||||.||||...|  ...        . ..... ...|. |.|..|. .||.
erlgiqylylpwpDhgvp.llellleflefidellalspg..gpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FVHH
|...
flyy

subfamily_ptpA1_pd Subfamily ptpA1 323-516 7.5e-36 118.8 In-house 48-256 (418) alignment
Range on Protein: 323-516
Range on HMM: 48-256/418.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGygGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPE----EQV
  ||||  |||  |.|| |   . |   | ||||||| |     | .|.||||.  |.||||||||...  ||||..   |.   ||  ||||    ||.
tsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

AY--DGVEI------TVQKVIHTEDY--RLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPH---CAPIIVHCSAGIGRTG
.   .| |.       . .||.  .     | | |    | | . .| .  |||.. ||.. |. .|.. . .  .|  |      |||||||||.||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

CFIATSICCQQL
 | .. |  ..|
tfctavimmkkl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 320-552 1.4e-35 117.3 In-house 35-265 (281) alignment
Range on Protein: 320-552
Range on HMM: 35-265/281.0
PGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQ--
|   .||||  |     ||| |    |.   . || |||||     .. || ||||   | ||||||.||| |  |||. .. | | |||.||.| .   
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

-VAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqegpHCAPIIVHCSAGIGRTGCFIATSICCQQ
 . .| . .. .     .      . |    | | . |. .  ||| . |. .  .|...|..         . .| ..|||||.||.| ..|  |. | 
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira.......rstppvihcsagvgrsgtlmaveialqs

LRQE-GVVDILKTTCQLRQ-DRGGMIQTCEQYQFVHHVM
..    . || .   .||   |   .|| .|| .. .|.
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 325-556 4.9e-35 115.8 In-house 36-259 (267) alignment
Range on Protein: 325-556
Range on HMM: 36-259/267.0
KNRYKTILPNPHSRVCLTSPDPDdplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekCTEYWPEE-QVAYDGVE
.||.   ||  ..|| |   . .     |||| |. ||   .. .|.||.|.  |..||. .. ... |.||..|.. . |     .|| .   |    .
rnrlddnlpyddtrvilrtkeee.....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..irlfwPPkmgqakkyqd

ITVQKVIHTE--DYRLRLISLKSGTEE-RGLKHYWFTSWPDQkTpDRApPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
.||.. .  |  ||..  . ||   |  . .  |..  |  . | .   | |. .  .    | |     |..|.||.|.||.| |.      .....||
ltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.t.nnk.pylkplfgilaknqle.ngnrPlvvacsdGvGrsGtflvidsqlerakteg

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
|.|| .   ..|. | |...| |.| ..|.... | 
vsdifdflrkirsqriglvdtkeryiyihellaeya

0051082 (Phosphotyrosine protein) phosphatases II 349-551 2.6e-34 113.3 In-house 1-148 (151) alignment
Range on Protein: 349-551
Range on HMM: 1-148/151.0
PLSSYINANYIRGYggeekvYIATQGPivstVADFWRMVWQEHTPIIVMITNIEEMNeKCTEYWPEEQvaydgveitvqkvihtedyrlrlislksgtee
|||.|||..|. |.      .....||     |||........   ||.... ||.. .|.||.||..                                
plsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg................................

RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqegPHCAPIIVHCSAGIGRTGCFIATSICCQQlrqegvVDILKTTCQLRQDRGGMIQTCEQYQFV
. ..|.....|||...|.  . .|........      .   |..||||||.||||...|  .....      |.. ..  ..|. |.|..|. .|..|.
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HHV
...
lfa

PTPc_DSPc_SM00012 452-552 3.1e-34 112.7 In-house 3-103 (105) alignment
Range on Protein: 452-552
Range on HMM: 3-103/105.0
KHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhCAPIIVHCSAGIGRTGCFIATSICCQQLRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..|.|||...|... ..|.|.|.|..  ....   .|..||||||.||||.|.| .|..|||..| . |||... ..||. | ||.||.|||.|...
khyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VM
..
al

0049260 (Phosphotyrosine protein) phosphatases II 367-550 7.9e-34 111.9 In-house 9-144 (152) alignment
Range on Protein: 367-550
Range on HMM: 9-144/152.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWpeeqvaydgveitvqkvihtedyrlrlislksgteerglkHYWFTSWPDQKTP
. .||||||   |.||||||... .  .|||.|. .|.. .|| .|.                                        .| .. |||  .|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhgvp

DRAPPLLHLVREVEEAAQQEGPhcaPIIVHCSAGIGRTGCFIATSICCqqlrqeGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .  || |.. .|..|...|    |..||||||.||||...|  ...        |.....  ..|. | |.... .|..|.. 
dlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 324-555 3.6e-33 109.9 In-house 43-276 (307) alignment
Range on Protein: 324-555
Range on HMM: 43-276/307.0
RKNRYKTILPNPHSRVCLTSPDpddPLSSYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQV---AY
 ||||. .    ..|. .. .      | || |||. |   . | .|..|||  .|. .|| |. ||.   ..|. .. |  . || .||| |.    ..
dknryqdvkcqdkgrivvkfdg...lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

--DGVEITVQK----VIHTEDYRLRLI--SLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqEgphCAPIIVHCSAGIGRTGCFIATSI
   .  |.|..     .  ..  . .    .. . . | ..|. .. |||. .|.     . |.  |.     .     |..||||||.||.|  .| |.
geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....d...tnpvvvhcsaGvGrsGtivaisl

CCQQL-RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
  ... . .   |. |   .||..|   |||  || ..| |.  |
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 324-556 5.8e-33 108.9 In-house 50-287 (305) alignment
Range on Protein: 324-556
Range on HMM: 50-287/305.0
RKNRYKTILPNPHSRVCLTSPDPDDplssYINANYIRGyGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQVA---Y
 ||||| .    . || | .| | .    || |||.     . | .| || |.  | |||| | .|..   | |. |. |   .||.||.. ..     .
gknrykdvgcldnnrvklegpwphe....yihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

--DGVEITVQkVIHTEDY-----------RLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVrevEEAAqqegPHCAPIIVHCSAGIGRTGCF
  .|  |.|. .  .. .           .  |.   .|.. |  .|| .  |||.  |     .| |.   |.|     |   ||.|||||||||||  
eekgqkisvk.fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell...ekar....pskgpivvhcsagigrtgsv

IATSICCQQLRQEGV-VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
.     ..|| .  .  |  |   ..|..|   ||| .|| ||| |.  | 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

0044763 (Phosphotyrosine protein) phosphatases II 334-553 6.6e-32 106.0 In-house 2-168 (178) alignment
Range on Protein: 334-553
Range on HMM: 2-168/178.0
NPHSRVCLTSPdPDDPLSSYINANYIRGYggeekVYIATQGPivstvADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQVaydgveitvqkviht
 ...||.|... .. . | ||||..| ..     .|.....|     ||.........   ||..|.  |.. .|| .|||||                 
ldrtrvllsnl.eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

edyrlrlislksgteerglKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQlrqeGVvDILKTTCQLR
                    .| .. .|| ..||    .| .|. .||| ...|    |..||||||.||.|...|  .....    |. .. .   ..|
...................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

QDRGgMIQTCEQYQFVHHVMS
. |  .... .|..... . .
erRp.ivpnpgqlrqLyefel

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 325-548 3.8e-31 102.9 In-house 53-273 (301) alignment
Range on Protein: 325-548
Range on HMM: 53-273/301.0
KNRYKTILPNPHSRVCLTSpdpdDPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMIT-NIEEMNEKCTEYWPE---EQVAYD
|.||.|.  .|.. | . .    |     | ||.|    |. . .||||||. .|  ||| |. | .   |||.. ..|...|||.|| |    |..  .
khryptvPckPstaveviv....dGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

GVEI--TVQKVIHTEDYRLRLISLKSGTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSICCQQ
  .|  . ...|  ..   | . ..  |.    | . || ...|.|. .|     | .|.  | .. .       ||.|||||||||. .||.| .  ..
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylare

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFV
.  .  ... ..  .||..|   .|| .|  ..
veadptieltealkhlrehrwngvqtnsqlywm

subfamily_CG42327_pd Subfamily CG42327 303-481 5.9e-31 102.3 In-house 10-193 (319) alignment
Range on Protein: 303-481
Range on HMM: 10-193/319.0
EFFEIPmNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSpDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIE
|| ..| ...   .   ..   |.|.  ..| |..|| | .  .||. . |..|.|.|||   .  |||.| .  .. .||||.||.  . .|| .|.. 
efrdlP.qliaradevPvtskdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

EMN-EKCTEYWPEE-----QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFtSWPDQKTPDRAPPLLHLVREVEEA
|   ..|.||.| .     . .|  . .|...    . | .  . ||   . | | | |||.  |.. . |    .|. .. ||...
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 367-550 1.2e-30 101.2 In-house 5-198 (199) alignment
Range on Protein: 367-550
Range on HMM: 5-198/199.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV---AYDGVEITVQKVIHTEDYRLRLISLKSGT----EERGLKHYWFTS
. ||||| |.  |.||||.|||.  .  |||. . .  .|     |||  .     |  . .|.. .    || .  . | . |      | . || |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL--RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .. ||. |  .  .|   | . . |  . ||.||||| | | || |.|  |  .     .  |||... . .||| | |.| . ..|.|.. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 367-550 1.2e-30 101.2 In-house 4-197 (198) alignment
Range on Protein: 367-550
Range on HMM: 4-197/198.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV---AYDGVEITVQKVIHTEDYRLRLISLKSGT----EERGLKHYWFTS
. ||||| |.  |.||||.|||.  .  |||. . .  .|     |||  .     |  . .|.. .    || .  . | . |      | . || |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL--RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .. ||. |  .  .|   | . . |  . ||.||||| | | || |.|  |  .     .  |||... . .||| | |.| . ..|.|.. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 323-555 6.8e-30 98.7 In-house 56-288 (305) alignment
Range on Protein: 323-555
Range on HMM: 56-288/305.0
VRKNRYKTILPNPHSRVCLTSPDPddplSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEEQVAYDG
. ||||. .  . .| | |  | |    | || |||.      || .|..|||.  |. .|| || |..   |||. .  |  . ||..|||  |     
itknryqdvpcqdqsavkldkpsp....sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VE--ITVQKVIHT----EDYRLRLISL--K-SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaqqeGPHcAPIIVHCSAGIGRTGCFIATSIC
.   | |..|  .     |  ...  |    || ..  ..|  .| |||.  |      | |.  .       | .  ||.|||||||||||  .|    
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gsk.vpivvhcsagigrtgtivaieyi

CQQLRQEGVV-DILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
 ... ..  .  . .    ||..|   ||.  || |.| ||  |
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 326-554 6.5e-29 95.8 In-house 39-268 (285) alignment
Range on Protein: 326-554
Range on HMM: 39-268/285.0
NRYKTILPNPHSRVCLTSPDPDdplssYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPE---EQVAYDG
|||  .     .|| |   | |     || |...|  | ..  ||.||||.  |..|||.|..||.   ..|. | .|   |||. |.||   | | .  
nryadvrcieetrvvlknhdrd.....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk

VEITVQKV-----IHTEDYRLRLISLKSGTE-ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIATSICCQQ
 |||. ..       |    | .|  .  .     ..|     |||| .|. | |.. | . |..   .|     || ||||||.|||  |.    .  .
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidyatir

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
. ..  ...|    ..|  |   .|.  |. |.. |.  
imenpniemldivremramrfqavqshmqflflyvvlme

subfamily_egg_pd Subfamily egg 325-556 2.9e-28 93.4 In-house 43-270 (307) alignment
Range on Protein: 325-556
Range on HMM: 43-270/307.0
KNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMnEKCTEYWPE---EQVAY--
| | | .  .  ||| |  .     |  .| ||...|       .| .| |.  || ||||||.||. . |||.|   |  |.|  |||    . . .  
karskrvhckdssrvklelrrG.qylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvp

DGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHyWftSWPDQKTPDRAPPLlHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSIC-CQQ
 ...|.  || .. |  .|.  ||      ||| |.| |   .  ... |   || ...| . ....       |..|..  |. ......|  |  .. 
GslrienlkvdskadplfrvtklklvGgddeerfleh.w..qgdvnnssdvyspl.rvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsl

LRQEGVVD-ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
||   .   .|..   ||. |   ...  .| ||. .. .. 
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 325-553 2.7e-27 90.6 In-house 46-268 (288) alignment
Range on Protein: 325-553
Range on HMM: 46-268/288.0
KNRYKTILPNPHSRVCLTspdpDDPlSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE--QVAYDG
..||. .     .|| |.    |||   ||.|| .      ..  | .| |. .|.  .|.|. ..    |||.... |   ||  ||.| .  . |  |
rdryenlprcditrvkls....ddp.dfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

VEITVQKVIHTEDYRLRLISL----KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVeeaaqqeGPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
   || |. ...  .|  .||    | | |.  .|.  .  |.|.  |.   . |.|.  .         .  ||.||.|||.|||| .| . |  ..||
rlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslr

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
 .  . | .   .||..|   |||. || .|| .. 
lddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 352-561 1.5e-25 85.0 In-house 47-264 (290) alignment
Range on Protein: 352-561
Range on HMM: 47-264/290.0
SYINANYIRGYGGeeKVYIATQGPI-------VSTVADFWRMVWQEHTPIIVMITNIEEMNEK-----CTEYWPE---EQVAYDGVEITVQKVIHTEDYR
 || ||..    |     |.|| |         ||. .|| |. ||.   .||. . || ...     |..| ||   |.. ..|...  .. .. .|  
dyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

LRLISLKSG-TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaA-QqegphcAPIIVHCSAGIGRTGCFIATSICCQQLR-QEGVVDILKTTCQLRQ
 | . .| .  ||  ..|... .| . ....    ||.|.. |.  | .      .|.||||  || |  .. |  . .| .  ..| | . .   .||.
tRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..ask......tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

DRGGMIQTCEQYQFVHHVMSLYEKQLSH
 |  .|.. ... ||  .. |. ..  .
qralaitsalelafvdagivllaievld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 323-427 1.1e-23 78.5 In-house 48-163 (350) alignment
Range on Protein: 323-427
Range on HMM: 48-163/350.0
VRKNRYKTILPNPHSRVCLT-SPDPDDP------LSSYINANYIRGY----GGEEKV-YIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCT
  ||||| |||  |||| |  |. . |        . ||||||..        . .  |||||.|. ||| ||.... . . ..|...|.  |.| ||| 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

EYWPEEQvaYDGVEITVQ
.||.| .  ||.. . ..
rYWqegs..ydditvkla

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 417-551 7.5e-23 75.5 In-house 57-189 (440) alignment
Range on Protein: 417-551
Range on HMM: 57-189/440.0
VAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphCAPIIVHCSAGIGRTGCFIATSICCQQL
.|||   . ...|    |      |  .| | | ||.| . .|||.  |  | |.|.....|.|. .. |   .|..|||||| ||||  ||     .. 
laydhsrvmleevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag..ngpllvhcsagagrtgviiavdsilrea

RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
..   .||.     .|..|  |.|| ||| |||..
krsdqidifsfinsmrnnrpqmvqtpeqyafvhea

0048076 (Phosphotyrosine protein) phosphatases II 440-552 2.8e-22 74.4 In-house 37-139 (145) alignment
Range on Protein: 440-552
Range on HMM: 37-139/145.0
ISLKSGTEeRGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIatsiCCQQLRQEGvVDILKTTCQLRQDRGGMI
 | ... | |   .|....|||  .|| .  ||.... .||| ...     |..||||||.||||...    ..  ....| |.. ..  ..|. | |..
tselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgav

QTCEQYQFVHHVM
.. .|..|.. . 
pnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 450-550 5.4e-21 70.3 In-house 48-139 (144) alignment
Range on Protein: 450-550
Range on HMM: 48-139/144.0
GLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIATSICCqqlrQEGvVDILKTTCQLRQDRGGMIQTCEQYQFVH
   .|....|||  .|| .  ||.... .||| ...     |..||||||.||||...|  ..      .| ... ..  ..|. | |.... .|..|..
egiqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl

H
 
e

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 351-557 6.8e-21 69.3 In-house 67-279 (312) alignment
Range on Protein: 351-557
Range on HMM: 67-279/312.0
SSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQ-EHTPIIVMITNIEEMNEKCTEYWPEE--------QVAYD--GVEITVQ-KVIHTEDYRLR
  || ||...     |. ...||||. .|.. ||...     | ||.... .|. .|||..|  .         .  |     || .  |      .|. 
nfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl

LISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGM
 . .|.  .|  |.|| ..||||.  ||     | |.  |    .       |.| |||||.|||| ..        ||.    .. ..   ||.||   
kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

IQTCEQYQFVHHVM--SLYEK
...  || .. ...   || |
vrvfpqyvyalrcvleflysk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 369-558 2e-20 67.4 In-house 92-287 (302) alignment
Range on Protein: 369-558
Range on HMM: 92-287/302.0
YIATQGPIVSTV---ADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWP---EEQVAYDGVEITVQKVIHTEDYR--LRLISLKSGTEERGLKH-YWFTSW
 | .| |.|...   ..|||||.||.   .|..   ||...   |..|   .. . |. . . ..|| ..|. .  . .  |  |  .  |   | .| |
iilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnW

PDQKTPDRAPPLLHLVREVeeaAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
...| |..   | . . .|    ... .  .....    |.|| | |..  .  ..| ..  . |  .  ..|..|  ......|| ... .. || |.
kqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 379-548 6.6e-20 66.3 In-house 40-213 (255) alignment
Range on Protein: 379-548
Range on HMM: 40-213/255.0
TVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE---QVAYDGVEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLL
||. |.... |  |  .||... .|   ||| .|.| |   .  .  |..|. | .     | . | .. |   . . .||| .. |.....|. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

HLVREVEEAaQqegphcaPIIVHCSAGIGRTGCFIATSICCQ----QLRQEG--VVDILKTTCQLRQDRGGMIQTCEQYQFV
.... | .. .       ...||||.||||.  |. . .  |    .|..     .| |.   .||. | . |.|  |  | 
nilkvvrds.k.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs

subfamily_CG42327_pd Subfamily CG42327 490-559 8.9e-19 62.3 In-house 248-318 (319) alignment
Range on Protein: 490-559
Range on HMM: 248-318/319.0
APIIVHCSAGIGRTGCFIATSICCQQLRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
 |..|||| |.||||  ||. |  ..| .    ||| ..  ..|.||.  ..| |||.|...|.| | |.|
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl

subfamily_hpo-7_pd Subfamily hpo-7 376-548 1.2e-18 62.0 In-house 43-219 (263) alignment
Range on Protein: 376-548
Range on HMM: 43-219/263.0
IVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE---QVAYDGVEITVQKVIHteDYRLRLISLKSG----TEERGLKHYWFTSWPDQKTPDR
.| |.. |.... |  |  .||... .|   ||| .|.| |   .  .  |.... ||..  |  |. . | |      . ...||| .. |.... |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

APPLLHLVREVEEAaQqegphcaPIIVHCSAGIGRTGCFIATSICCQ----QLRQEGV--VDILKTTCQLRQDRGGMIQTCEQYQFV
|   |.... . .  .       ...||||.||||.  |  . .  |    .|..     .| |.   .||. | . |.|  |  | 
areilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 323-428 2.5e-16 53.9 In-house 49-167 (349) alignment
Range on Protein: 323-428
Range on HMM: 49-167/349.0
VRKNRYKTILPNPHSRVCLT-SPDPDD------------PLSSYINANYIRGY-GGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EK
  ||||| |||  |||| |  |. .               |  ||||||..      || ||||| |. ||| ||....  .  .... ... .| . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CTEYWPEeqVAYDGVEITVQK
|  || |   .|..... .| 
cdiywqe..lsysnitvklqn

subfamily_eak_pd Subfamily eak 323-466 3.8e-16 53.4 In-house 53-196 (332) alignment
Range on Protein: 323-466
Range on HMM: 53-196/332.0
VRKNRYKtILPNPHSRVCLTSPDPDdPlSSYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPEEQ---VA
|..| .| |.|. .  | |||   . .   ||||  .  .    . || |  .  . |  ||.|| ....| ||..  ..|.  ||   |.|..    . 
vnrnvvk.ivpydrylvrltssqln.r.lGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPD
.  .... .. .. . .. ||. |. | |   ..|| .  | . ..| 
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 323-552 4.2e-16 53.4 In-house 48-275 (303) alignment
Range on Protein: 323-552
Range on HMM: 48-275/303.0
VRKNRYKTILPNPHSRVCLTSpdpddplSSYINANYIRGygGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTE-YWPEEQ--VAY
. |||.  ..   ||.| |.        |||| |.|.      .|  | || |.  | ||||.|. ...   ....    |...   .  .|..|  . .
mdknrfvdvicldhskvklsd.......ssyihasylel..dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

DGVEITV---QKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDR-APPLLHLVREVEEAAQQEGPHCaPIIVHCSAGIGRTGCFIATSICCQQ
.   | |   ..|  .. . |...|.  |.    |. . . .|| .. |   .| ... . ...   ..  .   | .    .| ||.| |     .   
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfetahls

LRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
| .|   .|..|   ..|. |   .|   |. .|. ..
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 323-418 1.8e-15 51.3 In-house 53-146 (310) alignment
Range on Protein: 323-418
Range on HMM: 53-146/310.0
VRKNRYKTILPNPHSRVCLTSPDpdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVA
. ||||  ..    ||| |.          || |||..      . .| .|||.  |. |||||..|| .  |... .  ||   ||  |||   |.
mhknrysdvvcldtsrvklkidk..sryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 372-548 3.8e-14 46.8 In-house 96-280 (302) alignment
Range on Protein: 372-548
Range on HMM: 96-280/302.0
TQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE---QVAYD-------GVEITVQKVIHTEDYRLRLISLKSGTE----ERGLKHYWF
   |  ||.  .| .. | .. |.| .... |. ..||.||. ..   .. .         |.  ...    ....|  . .|        .. ..   |
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TSWPDQKTPDRAPPLLHLVREVEEAAQQegphcapIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFV
..|||  .|. | . |....  |   ..       ..||||||.|||| ..|     |   .. | |.|.  . .|| | | .|. .|  ..
sawpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 493-551 8.4e-11 36.1 In-house 2-60 (69) alignment
Range on Protein: 493-551
Range on HMM: 2-60/69.0
IVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
.||||.| |||| |||  .   ... | .|||.     .|. |  |.    .| |.|  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 493-552 8.6e-11 36.0 In-house 1-60 (69) alignment
Range on Protein: 493-552
Range on HMM: 1-60/69.0
IVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||||.| |||| |||  .   ... | .|||.     .|. |  |.   ..| |.|  .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-557 1.6e-10 35.0 In-house 197-291 (310) alignment
Range on Protein: 456-557
Range on HMM: 197-291/310.0
FTSWPDQKTPDRApplLHLVREVEEAAQQEGphcaPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.  |||.  ||      | | .   |  . |    | .||||||..|... .|  .  ..|..   ||. .   .|...|   |||  || ....|. ..
wpnwpdrgvpdek...chtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

EK
 .
ar

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 323-405 2.3e-10 34.5 In-house 38-121 (347) alignment
Range on Protein: 323-405
Range on HMM: 38-121/347.0
VRKNRYKTILPNPHSRVCLTsP-----DPDDPLSSYINANYIRgYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMItnIEEMN
. ||| |    .  .|| |. |      . |.  .|||| .|. .   .| || || |. .|| |||.||   .   .| |  .| ..
lsknrskdvklidatrvvls.peksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti..fepik

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 352-427 2.6e-09 31.5 In-house 14-85 (130) alignment
Range on Protein: 352-427
Range on HMM: 14-85/130.0
SYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekctEYWPEEQ-VAYDGVEITVQ
 ||||... |  |  . |. || |.  |  |||.|. . .  ..|..  .|| .    ||||. . . .   .|.| 
tyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 366-413 7.8e-09 29.3 In-house 235-280 (440) alignment
Range on Protein: 366-413
Range on HMM: 235-280/440.0
EKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEmnEKCTEYWP
 . .|||| |. ||| ||||.| . .   |.|. ....    |. |||
knafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywp

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 483-556 8.2e-09 29.6 In-house 256-344 (350) alignment
Range on Protein: 483-556
Range on HMM: 256-344/350.0
QQEGPHCAPIIVHCSAGIGRTGCFIATSICCQ------QLRQE--------GVVD-ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
  .  . .||.||||||.|||| ...     .      .|..|         . | |  .  .||. |  |.|. .|. |... .  | 
hldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 366-426 4e-08 27.2 In-house 136-193 (244) alignment
Range on Protein: 366-426
Range on HMM: 136-193/244.0
EKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekctEYWPE-EQVAYDGVEITV
   || || |.  |  |||.|. . |  ..|..  .|| .    ||||. | . .   .|||
taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditv

0038934 (Phosphotyrosine protein) phosphatases II 459-553 7.3e-08 27.8 In-house 87-174 (194) alignment
Range on Protein: 459-553
Range on HMM: 87-174/194.0
WPDQKTPDRAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQqlrqeGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
.||. |.     ||. .. |.|  ..  ..   . ||| ||.||||...|  . .         .  .    .|. |.|.|.. .... ..  ..
fpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkryk

subfamily_PTPDC1_pd Subfamily PTPDC1 449-552 8.1e-08 26.9 In-house 81-172 (182) alignment
Range on Protein: 449-552
Range on HMM: 81-172/182.0
RGLKHYWFtSWPDQKTPDRaPPLLHLVREVEEAAqQEGphcaPIIVHCSAGIGRTGCFIATSICC-QQLRQEGVVDilkttcQLRQDRGGMIQTCEQYQF
.|. .| | .|.| ...     .| .|. |. |  |||     . ||| || ||||  ||. .   ..|  |  ..       .|. |   ||| || ..
qgiyvynf.gwkDygvasl.eriLdivkvvafal.qeg....kvavhChaGlGrtGvliacylvyakrltaekaik......lvrskrpksiqtreqvel

VHHVM
|.. .
vkefa

subfamily_DSP23_pd Subfamily DSP23 463-557 2.3e-07 25.6 In-house 58-147 (148) alignment
Range on Protein: 463-557
Range on HMM: 58-147/148.0
KTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIAtsicCQQLRQEGVvDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
. .|  || |. | |  .  ..   .   . |||  | |||| ..|    |  ......    ..  ..|. | | ..| || . |..  ....|
riddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmla....cylvkerkl.aaaeaiaevrrlrpgsvetveqeklvrdyetfink

subfamily_CDKN3_pd Subfamily CDKN3 459-560 2.9e-07 24.3 In-house 107-200 (202) alignment
Range on Protein: 459-560
Range on HMM: 107-200/202.0
WPDQKTPDRAPpLLHLVREVEEAAQQegphCAPIIVHCSAGIGRTgCFIATsicCQQLRQEGVVDILKTTCQLRQDRG-GMIQTCEQYQFVHHVMSLYEK
 .|  .|| |   |... |.  . ..        .|||  |.||. .....   |  |  . ...  ..  .||. .| . |||  ||.....     |.
iadglvpdias.clkileelrinlka....yrktlvhcygglgrs.slvia...clllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdklee

QLS
 ||
yls

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 450-548 3.9e-07 23.9 In-house 228-330 (347) alignment
Range on Protein: 450-548
Range on HMM: 228-330/347.0
GLKHYWFTSWPDQKTPDRAPPLLHLVRE-VEEAAQQ---EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQY
  | |  |.|| .| ||    .| |||  | |...    .  . ||..| |  |. |.   . |||  .|. .    |  .   ..|..| |..     |
fakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsify

QFV
 . 
tya

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 376-551 4.9e-07 22.7 In-house 127-304 (346) alignment
Range on Protein: 376-551
Range on HMM: 127-304/346.0
IVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGV---EITVQKVIHTEDYRLRL-ISLKSGTEERGL-KHYWFTSWPDQKTPDRAPP
  | | ||| |..||.  .. ..   . ...  |  . .|.  |.      |  ..   . | .      |  |  .  . . .  . |   . | .. |
nesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlp

LLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
..... .     |    . | . |    | ||. .|| .    .|| .    .|..   ...|.| | ...  ||  .. .
iikmihqflsekqv...qnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

subfamily_PTEN_pd Subfamily PTEN 465-558 6.8e-07 24.4 In-house 88-182 (184) alignment
Range on Protein: 465-558
Range on HMM: 88-182/184.0
PDRAPPLLHLVREVEEAAQQ--EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRqEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
 |  || |.|..|. | ...  |  .   ..||| || ||||  |.. .  ..|  |   ..|.   . |   .  ..   |  .|... .|.|..
dDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee

PTEN_1 467-508 2.1e-06 22.7 In-house 106-149 (196) alignment
Range on Protein: 467-508
Range on HMM: 106-149/196.0
RAPPLLHLVREVEEAAQQEG--PHCAPIIVHCSAGIGRTGCFIA
 ||.| .| .........    |.   ..||| ||.||.|. .|
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 326-411 3e-06 20.9 In-house 38-120 (332) alignment
Range on Protein: 326-411
Range on HMM: 38-120/332.0
NRYKTILPNPHSRVCLTspdPDDPLSSYINANYIRGYGgEEKVYIATQGPIVS-TVADFWRMVWQEHTPIIVMITNIEEMNEKCTEY
||   .    |||| |.   |.|    . ||... ||  ..  || .| |.   |   ||||| . .  .|... .|.| ... . |
nriphlycfdhsrvela...pqdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapy

subfamily_CDC14_pd Subfamily CDC14 490-551 4.3e-06 20.8 In-house 264-320 (328) alignment
Range on Protein: 490-551
Range on HMM: 264-320/328.0
APIIVHCSAGIGRTGCFIATSICCQqLRqegvVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
  |.||| ||.||||..||. .  .  |    .    .   ||  | |.. .  |  .... 
GaiavhCkaGLGrtGtLiacylmkh.yr....ftaaeaiawlricrPGsvigpqqkfleekq