Gene PTPN7 in Homo sapiens

Synonym: BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI, RP11-294K24.3, PTPN7

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP083_AA protein Get Run
HsapP083_AA_186-457 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 198-459 1.3e-123 406.5 In-house 3-271 (274) alignment 
Range on Protein: 198-459
Range on HMM: 3-271/274.0
SPKQLEEEFLKIPSNFvSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQED-GDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLI
|.|.||.|||..|.|| ..|.||..|...|.||||||||..|||.| ...|...  .|||||||.|||...|.|.|||||.||||.|||.|..||||..|
sfkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMLTQLREGKE-KCVHYWPTEEET-----YGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHP-
||||.|.| .| ||..|.|..|..     || ..|......|. .|.||.|...|.|..|||||.....||||..|..| .||.||.||||| |..... 
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQL
.|.||||||||||||||||..|...||.... ||.|.|||.||||||||.||.|||...|..|.||. .|
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPRD_pd Subfamily PTPRD 200-455 1.6e-91 302.7 In-house 23-280 (564) alignment 
Range on Protein: 200-455
Range on HMM: 23-280/564.0
KQLEEEFLKIPSNFVSP-EDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVM
 ..|||. || ..  .. |  . |   .| ||. |..  .|||.| . . .|. |||||..| ||. |.| |||||||...|..||| |||....| |||
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVm

LTQLRE-GKEKCVHYWPTE-EETYGPFQIRIQDMKECPEYTVRQLTI--QYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaAHPGPIVV
||.|.| ||.|| .|||.. .|||| ... ... .|  .|..|....  . ..| | |..  | .||||  |||| .||.|. .|... |   . |||||
ltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivV

HCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
|||||.||||.||.  .  ...|. . ||| ..| .|| .|  |.|| |||.|.|.... .
hCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
0050432 (Phosphotyrosine protein) phosphatases II 193-456 5e-89 294.0 In-house 35-299 (308) alignment 
Range on Protein: 193-456
Range on HMM: 35-299/308.0
QRQPPSPKQLEEEFLKIPSNFVSPE--DLDIPGHASKDRYKTILPNPQSRVCLgraqsQEDGDYINANYIRGYD-GKEKVYIATQGPMPNTVSDFWEMVW
  .. ....||||| ...|.....|      | . .| ||| |||. .|||.|     .|. |||||.|..||. .... .||||||.|||| ||| |||
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

QEEVSLIVMLTQLREGK-EKCVHYWPTEEE----TYGPFQIRIQDMKECPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEES
...|..|||||.| | . ||| .|||.|..    .||.|.... .......||||.|....   .| | |.|. . .||||..|.|. .||... .|..|
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

PetaaHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
      .||||||||||.||||.|||  . ..||.. |.||....|..||  | ||.|| |||.||...|. |.
l....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0039614 (Phosphotyrosine protein) phosphatases II 187-457 1.1e-88 292.9 In-house 19-290 (297) alignment 
Range on Protein: 187-457
Range on HMM: 19-290/297.0
LTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQ-EDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFW
|... | ... |. .|..|| ...|.... .    | . .| ||| |||...|||.|    .. .| |||||.|. |||   . .||||||.|.|| |||
ldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

EMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPET
.|||.. |. |||||.| | . ||..|||.|..|||.|...  . .... ||||.|.... .| | |.|...  ||||..|.|.  ||... .|.|  ..
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

AAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAG
.  .||..||||||.||||.|||  . ..||. .|.||.| .|..||  |.|..|| .||.||.. |. .  
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0051299 (Phosphotyrosine protein) phosphatases II 187-456 8.6e-88 289.8 In-house 10-286 (288) alignment 
Range on Protein: 187-456
Range on HMM: 10-286/288.0
LTRWALQRQPPSPKQLEEEFLKIPSNFVSPE--DLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDF
|... |.... ....|.||| ...|......      | . .| ||. |||. .|||.|   ...|..|||||.||.||. | | .||||||.||||.||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedF

WEMVWQEEVSLIVMLTQLREG-KEKCVHYWP-TEEETYGPFQIRIQDMKECPEYTVRQLTIQ------YQEERRSVKHILFSAWPDHQTPESAGPLLRLV
| |||...|..|||||.| |  .||| .|||  . .|||...... .......||||.|...      ...| | |.|. . .||||..|.|. .||...
WrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

AEVEESPEtaAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
 .| .. .  ...||.|||||||.||||.|||  . ..||...|.||.|..|..||  | ||.|| |||.|....|. |.
rlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 202-456 5.9e-87 286.9 In-house 2-274 (284) alignment 
Range on Protein: 202-456
Range on HMM: 2-274/284.0
LEEEFLKIPSNFV----SPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQ-EDGDYINANYIRGYD----GKEKVYIATQGPMPNTVSDFWEMVWQEE
||||| ...|..|    | .    | . ||.||| |||. .|||.| . ... ||.|||||.|..|||     ..| .||||||.|||| ||| |||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSLIVMLTQLREGK-EKCVHYWPTEE--ETYGPFQIRIQDMKECPEYTVRQLTIQY---QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETA
|..|||||.| | . ||| .|||.|.   |||.|.... ...... |||| |....    .| | |.|. . .||||..|.|. .||... .|.|. |  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

AHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARG---EVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
  .||||||||||.||||.|||  . ..||...|   .||.|..|..||  | ||.|| |||.|....|. |.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 193-455 2.5e-85 281.5 In-house 5-271 (273) alignment 
Range on Protein: 193-455
Range on HMM: 5-271/273.0
QRQPPSPKQLEEEFLKIPSNFVSPE--DLDIPGHASKDRYKTILPNPQSRVCLgraqSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQ
 ... ....|.||| ...|.... .      | . .|.||| |||. .|||.|    .... |||||.|..||. | | .||||||.|||| ||| |||.
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvwe

EEVSLIVMLTQLREG-KEKCVHYWPTE----EETYGPFQIRIQDMKECPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESP
. |..|||||.| |  .||| .|||.|    ..|||.|.... ...... ||||.|....   .| | |.|...  ||||..|.|  .||... .|..  
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

ETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
|.. ..||.|||||||.||||.|||  . ..||...|.||.| .|..||  | ||.|| |||.||...|. |
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0040438 (Phosphotyrosine protein) phosphatases II 190-456 4.3e-84 277.8 In-house 8-276 (317) alignment 
Range on Protein: 190-456
Range on HMM: 8-276/317.0
WALQRQPPSPKQLEEEFLKIPSNFVSPEDL-DIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMV
. |.. ... ..|.||| ...|..... .    | . .|.||. |||...|||.|   .. .| |||||.|. |.. | | .||||||.|||| |||.||
alldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmv

WQEEVSLIVMLTQLREG-KEKCVHYWP-TEEETYGPFQIRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPE
|.. |..|||||.| |  .||| .|||  |. |||.|........|....|.|.|...  . .| | |.|. . .|||| .|.|  .||... .|.|. |
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

taAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
   ..||..||||||.||||.|||  . ..||. .|.||.  .|..||  |.|..|| |||.||.  |. | 
..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0036941 (Phosphotyrosine protein) phosphatases II 195-456 1.2e-83 276.1 In-house 8-277 (297) alignment 
Range on Protein: 195-456
Range on HMM: 8-277/297.0
QPPSPKQLEEEFLKIPSNFVSPE--DLDIPGHASKDRYKTILPNPQSRVCLgraqSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEE
.. .. .|..|| ..........      |.. .|.||| |||....||.|    ..|. |||||.|. ||| | | .||||||.|||| ||| |||.. 
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqn

VSLIVMLTQLRE-GKEKCVHYWP---TEEETYGPFQIRIQDMKE--CPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPE
|. |||||.| | |.||| .|||    |. |||.|... .....  ...||.|.|....   .| | |.|. .  |||| .|||. .||... .|..  .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

TAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK---ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
 .  .||..||||||.||.|.|||  . .|||.    .|.|||| .|..||  | |..|| |||.||...|. . 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 224-453 1.9e-83 274.9 In-house 51-282 (293) alignment 
Range on Protein: 224-453
Range on HMM: 51-282/293.0
HASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE--EETY
 ..|.||. |||  .||| |   ..... ||||||||.||  . . .||||||.|.|| |||.|||....| ||||||| | ||.|| .|||..  . .|
nraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvly

GPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARG
|  .. ..  .|  ....|.|.|. ..|.|.|..  | .||||  ||.. .||..| .|.|. |..|. .|||||||||.|||| |||     |... . 
GdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeed

EVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
 |||.|||..|| .|  ..|| .|| |.|... 
yvdifgivaelReeRnllvqtekqYifihqcvl
DSPc_SM00195 202-455 2.4e-83 274.9 In-house 2-261 (263) alignment 
Range on Protein: 202-455
Range on HMM: 2-261/263.0
LEEEFLKIPSNFV--SPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYdGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVML
|.||| |. ..    . .. ...   ||.||| |||. ..|| | . ...|. ||||||||.|.  |.| |||||||.|.||.|||.|||.|.|..||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLRE-GKEKCVHYWPTE---EETYGPFQIRIQDMKECP-EYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAahPGPI
|.  | ||||| .||| |   .||.| ... ... .... |...|.|......  | |.|... . .||||..|.|. ..|.|. .|..| .|    |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
|||||||.||||.|... | ...|..  .|||  ||..||  | ||.|| |||.|...... |
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 202-455 2.4e-83 274.9 In-house 2-261 (263) alignment 
Range on Protein: 202-455
Range on HMM: 2-261/263.0
LEEEFLKIPSNFV--SPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYdGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVML
|.||| |. ..    . .. ...   ||.||| |||. ..|| | . ...|. ||||||||.|.  |.| |||||||.|.||.|||.|||.|.|..||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLRE-GKEKCVHYWPTE---EETYGPFQIRIQDMKECP-EYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAahPGPI
|.  | ||||| .||| |   .||.| ... ... .... |...|.|......  | |.|... . .||||..|.|. ..|.|. .|..| .|    |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
|||||||.||||.|... | ...|..  .|||  ||..||  | ||.|| |||.|...... |
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0043336 (Phosphotyrosine protein) phosphatases II 192-455 9.9e-82 269.8 In-house 12-276 (278) alignment 
Range on Protein: 192-455
Range on HMM: 12-276/278.0
LQRQPPSPKQLEEEFLKIPSNFVSPEDLD-IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQ
|.. . ... |..|| ...|... . .    | . .| ||| |||...|||.|   .. .| |||||.|. ||. ..| .||||||.|.|| |||.|||.
lelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwe

EEVSLIVMLTQLREG-KEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaA
. |. |||||.| |  ..||..||| . .|||.|... ....... ||||.|..   .  | | | |. . .||||..|||  .||... .| |  |   
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..d

HPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
 .||..||||||.||||.|||  . ..||. .|.||.. .|..||  |.|..|| .||.||.. |. |
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 190-455 5e-81 268.1 In-house 17-303 (307) alignment 
Range on Protein: 190-455
Range on HMM: 17-303/307.0
WALQRQPPSPKQLEEEFLKIPSNFV----SPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQ-EDGDYINANYI--------RGYDGkEKVYIATQGP
. |.... ..  |..|| |..|  |    . .    | . .| ||| |||....||.|   ... ||.|||||.|.         |||   . .||||||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgP

MPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE--EETYGPFQIRIQDMKECPEYTVRQLTIQ---YQEERRSVKHILFSAWPDHQTPESAG
.|.|| |||.|.|.. |..|||||.| | |.|||..|||.|  | |||.|...  .......||||.|...   . .| | |.|. . .||||..|.|  
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfe

PLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGE---VDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
.||... ||..  |.   .||..||||||.||||.|||  . ..||...|.   ||.| .|..||  |.|..|. |||.||.. |. .
elldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 225-452 5.2e-81 266.9 Pfam-A 2-233 (235) alignment 
Range on Protein: 225-452
Range on HMM: 2-233/235.0
ASKDRYKTILPNPQSRVCLgrAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWP---TEEETY
 .| |||.|||  ..|| |   .|... |||||||..||. ..| .||||||...|..|||.|||||.|..|||||.| | |.||| .|||    |..||
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFQIRIQ-DMK-ECPEYTVRQLTIQYQEER---RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPetAAHPGPIVVHCSAGIGRTGCFIATRIGCQQ
| ...... . | .. |||.|.|... ..|.   |.||.. . .||||..|||. .||.|. .||.|   .|. ||.|||||||.||||.|.|  | ..|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
|.|..|||.| ||..||  | ||.|..|||.||....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 225-452 5.2e-81 266.9 In-house 2-233 (235) alignment 
Range on Protein: 225-452
Range on HMM: 2-233/235.0
ASKDRYKTILPNPQSRVCLgrAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWP---TEEETY
 .| |||.|||  ..|| |   .|... |||||||..||. ..| .||||||...|..|||.|||||.|..|||||.| | |.||| .|||    |..||
kkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPFQIRIQ-DMK-ECPEYTVRQLTIQYQEER---RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPetAAHPGPIVVHCSAGIGRTGCFIATRIGCQQ
| ...... . | .. |||.|.|... ..|.   |.||.. . .||||..|||. .||.|. .||.|   .|. ||.|||||||.||||.|.|  | ..|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
|.|..|||.| ||..||  | ||.|..|||.||....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0045098 (Phosphotyrosine protein) phosphatases II 199-458 7.9e-77 253.6 In-house 8-274 (278) alignment 
Range on Protein: 199-458
Range on HMM: 8-274/278.0
PKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVClgraqsqedgDYINANYIRGYdgKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVM
. .|| ||| ..... . ..   .|...|.||| |||...|||.          |||||.||.||  . | .||||||.|.||.|||.|.|.. .. |||
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivm

LTQLREG-KEKCVHYWPTEE-ETYGPFQIRIQDMKECPEYTVRQLTIQ------YQEERRSVKHILFSAWPDHQTPESA--GPLLRLVAEVEESPE----
||.| |. .|||..||| .. .|||.|............||.| |...      .  | | |.|. .  |||| .|..    ..|.|. ...|  .    
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

-------TAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLkaRGEVDILGIVCQLRLDRGG-MIQTAEQYQFLHHTLALYAGQ
       .  ..||..||||||.||||...|  . ...|   | ||.| .|..||  |.| ..|. |||.||.. |...  .
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 222-455 8.8e-77 253.3 In-house 9-245 (249) alignment 
Range on Protein: 222-455
Range on HMM: 9-245/249.0
PGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWP-TEEET
| . .|.||. |||...|||.|.  .. ...|||||.|| ||. | . .||||||.|.||.|||.|.|.. .. |||||.| |  .||| .|||  .. .
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

YGPFQIRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK
|| |...  .......||||.|...  |  | | |.|| .  ||||..|.|  .||... .|..  |..  .||..||||||.||||.|||  . ..||.
ygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqle

ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
 ...||.. .|..||  |.|..|. |||.||.  |. .
kelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 222-454 5.3e-76 250.4 In-house 45-277 (288) alignment 
Range on Protein: 222-454
Range on HMM: 45-277/288.0
PGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWPTEEE--
.  |.|.||. |||  . || |   . ... |||||.|| |.. |.|.|||||||...|| ||||.|.....| |||||.|  .||.|| .|||....  
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk

TYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAahPGPIVVHCSAGIGRTGCFIATRIGCQQLKA
 || ... ... ||  ....|.| .. ..... ...  . |||||. |||. ||| |.  |. . .     |||.||||||.|||| |||     .....
nyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidavee

RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLAL
   .|..|.|..||  |  ..|| .||.|....|. 
edyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 221-453 1.8e-75 248.9 In-house 43-277 (318) alignment 
Range on Protein: 221-453
Range on HMM: 43-277/318.0
IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEE-E
 |  . |.||  ||.  ..|| |   ...|. |||||||| ||  ..| |||.|.|.|.|..||| |||. . ..||||||..| ||.|. .||| .. .
epvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr

TYGPFQIRIQDMKECPEYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtAAHPGPIVVHCSAGIGRTGCFIATRIGCQQL
.||  .. ... .|. .|..|..... .|  | | |.   . .|||. .|||.. || || .|..  .  .  ||||||||||.|||| |||  |  ...
sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfiavdilleri

KARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
|| . ||....| |||  |  |.|| .||.|....| 
kaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 200-455 6.3e-74 243.8 In-house 22-282 (305) alignment 
Range on Protein: 200-455
Range on HMM: 22-282/305.0
KQLEEEFLKIPSNfVSPEDLDIP-GHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVM
|.||... .....  .. |..    ...|.|.| | . ...|. |   .|..| |||||.|. ||..| | ||..|||..|||.|||.....| || |||
kgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivm

LTQLREG-KEKCVHYWPTEEET---YGPFQIRIQDMKECPEYTVRQLTIQY---QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaAHPGP
||.|.|| |.||  |||...     .|.|.. ... |. ..|. |.|.|     ..| |.| .  .  ||||  |..|. ||.|. .|... .   .  |
ltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvp

IVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
..||||||.|||| |||  |  ..||. ..||. ... |||  | .|.|| .||.|||  |...
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 222-457 4.4e-73 240.6 In-house 15-265 (270) alignment 
Range on Protein: 222-457
Range on HMM: 15-265/270.0
P---GHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEE
|    ..  .||. |||.|..||.| . ....   ||||||.||.||..| |||..||.|.|...|| |.|.|.|. |||.|.| | |..||  |||.| 
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

ET---YGPFQIRIQDMK--ECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAG------PLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCF
..   .   .|..  ..      | ...|..... |.| . |  . .||||  |....       ||.....| .| .  .. .|..||||||.||||..
kekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

IATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAG
||. |... |. ...||.| |. .|| ||  ..|. |||.||......|| 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0042113 (Phosphotyrosine protein) phosphatases II 222-455 6.9e-73 240.3 In-house 7-242 (245) alignment 
Range on Protein: 222-455
Range on HMM: 7-242/245.0
PGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWP-TEEET
| . .| ||. |||....||.|   ....| |||||.|. ||. ..| .||||||.|.|| |||.|.|.. .. |||||.. | |..|| .|||  |. |
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

YGPFQIRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK
|| |...  ... ...||||.|...  .  | | | |...  ||||..|..   ||... .|..  .    .||..||||||.||||.|||  . ..||.
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqle

ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
....|..  .| .||  |.|..|| .||.||.. |. .
kelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 195-455 1e-72 239.9 In-house 18-282 (319) alignment 
Range on Protein: 195-455
Range on HMM: 18-282/319.0
QPPSPKQLEEEF--LKIPSNFvSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEE
.  . ..||.||  ||...|. . .  . .   .|.||. ||.  ..|| |   . .|. |||||..| ||. .|| .||||.|. ||..||| |||.||
astgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerek.fiatqaPlentiedfWrmvWeee

VSLIVMLTQLRE-GKEKCVHYWPTEE-ETYGPFQIRIQDMKECPEYTVRQLTIQYQE---ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAa
.| .||||.| | .| |. .|||.|. |.|| . . ... .|  .| .|.|... .    | |.|||  . .||||. ||.|  || |. ....| |   
ssivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.

HPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
. ||||||||||.|||| ||.  .  ...|  | .|.  .| .||. |  |.|. |||.|....|  .
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN6_pd Subfamily PTPN6 222-456 1.3e-72 239.4 In-house 52-297 (306) alignment 
Range on Protein: 222-456
Range on HMM: 52-297/306.0
PGHASKDRYKTILPNPQSRVCLGrAQSQEDGDYINANYIR-GYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEE--
|  ..|.|||.|||  ..|| |   .|  . ||||||||.    |..| |||||| ...||||||.|||||.  .|||.|.  | |||||..|||.||  
penkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

ETYGPFQIRIQDMKECPEYTVRQLTIQ---YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAA--HPGPIVVHCSAGIGRTGCFIATRIG
|.||  ...  . |.  .|..|.|...    ..| |.| .  | .|||| .|.. | .| .. .|..  |. .  ..||||||||||||||| || . | 
eeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

CQQLKARG---EVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
 .... .|   ..||  .| ..|  | |..||..||.|...... | 
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN12_pd Subfamily PTPN12 222-453 1.8e-72 238.7 In-house 38-274 (290) alignment 
Range on Protein: 222-453
Range on HMM: 38-274/290.0
PGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE--E-
. .  |.||| |||  .||| | . ...|. ||||||.|.| .|| . |||.|||.|.|..||| |.|. .|...||. .. | || || .||| |  | 
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk.leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

ETYGPFQIRIQDMKECP-EYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaAHPGPIVVHCSAGIGRTGCFIATRIGCQQL
 ..|.|..  .. | .  ....|.|... |.|.|.|. . . |||||..|.|| .||.|...|.|  |  ..  |.|||||||.||||  ||  .  ..|
lefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrell

KARGE---VDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
||.     .|.  .| .|| .|  ..|| |||.......|
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykava
0037934 (Phosphotyrosine protein) phosphatases II 222-454 1.9e-71 235.7 In-house 8-240 (243) alignment 
Range on Protein: 222-454
Range on HMM: 8-240/243.0
PGHASKDRYKTILPNPQSRVCLgraqsqEDGDYINANYIRGYDGkekvYIATQGPMPNTVSD----FWEMVWQEEVSLIVMLTQLR-EGKEKCVHYWPtE
| . || ||..|||...|||.|      |..||||||.|.....    .||||||.|.|| |    ||.|.|.. .. |||||.|   |.|||..||| .
penlsknrysdilpydhsrvkl......egsdyinanliyvtpr....liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.g

EETYGPFQIRIQDMKECPEYTVRQLTIQY---QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPET------AAHPGPIVVHCSAGIGRTGCFI
|.|||.|.... .......|||| |....   ... | | |... .||||..|.|  .||... || |  |       . . ||..||||||.||||..|
evtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

ATRIGCQQLkargEVDILGIVCQLRLDRGG-MIQTAEQYQFLHHTLAL
|  . ...|    .||.. .|..||  |.| ..|| .||.||.. |. 
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 225-452 1.9e-71 235.8 In-house 57-286 (298) alignment 
Range on Protein: 225-452
Range on HMM: 57-286/298.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEkVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPT-EEETYGP
 .| ||  |..  .||| | . ...|..||||| .. .|.|..  .||||.|...||.||| ||..|... |||||.|.|  | |. .|||. ..|||| 
kkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyge

FQIRIQDMKECPEYTVRQLTIQYQ--EERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAaHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARG
......  .|  ...||.|... .  |..|.|... |. |||...|| |  .| |...|. |.. |    |..|.||||.||.| |||     ...|.  
itvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa.gnkpvivqCsaGvgRsGtfiaidsvlervkkeq

EVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
 ||.. .|  || .| |..|| ||| |...  
vvDvfqvvkvlRkkrpgavqteeqYvfiyeav
subfamily_PTPRA_pd Subfamily PTPRA 198-455 3.8e-69 228.1 In-house 30-294 (330) alignment 
Range on Protein: 198-455
Range on HMM: 30-294/330.0
SPKQLEEEFLKIPSNFV--SPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSL
  |.. |||  .|.  .  . |  .      |.|.  |||.  ||| |   . .|. ||||| .| ||  |.| .||.|||  .|| ||| |.|. . . 
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdk.fiaaqGPkeetvedfwrmiweqksat

IVMLTQLREGK-EKCVHYWPTEE-ETYGPFQIRIQDMKECPEYTVRQLTIQ------YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAA
|||||.|.| | |||  |||.|   |||  .. ..|.... .||||.. .|       ... | |. . | .|||   |  .  .|.|...|..  .  |
ivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

HpgPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
   |||||||||.|||| ||.     ...|| . ||. ..| .||| |  |.|| |||.|....|  |
g..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 225-451 6.4e-69 227.2 In-house 44-272 (314) alignment 
Range on Protein: 225-451
Range on HMM: 44-272/314.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGK-EKCVHYWPTEEETYGPF
 .|.|.. ||.  .||| |   . . . |||||..| .|  . . .|.||||...|| ||| .|..|. . |||||.| |    ||..||| . |.||..
reknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

QIRIQDMKECPEYTVRQLTIQY----QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaaHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR
.. . ...   |. || ....     |||.| |... | .||||..| ||  ||.||..|..| |   . |.|||||||| ||||.|||  | .. .. .
kvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmiere

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
| ||.  .| .||  .  |..| |||.|..  
gvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_PTPRG_pd Subfamily PTPRG 225-452 5.1e-68 224.6 In-house 48-283 (563) alignment 
Range on Protein: 225-452
Range on HMM: 48-283/563.0
ASKDRYKTILPNPQSRVCLGRAQSQEDG-DYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWPTEE-ETYG
  | ||  |..  .||| |     ...  |||||||| ||  |.| .||||||...|. ||| |.|...|..|||.|.|  .|..||  |||..| ||||
krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetyg

PFQIRIQDMKECPEYTVRQLTIQY-------Q-EERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESpeTAAHPGPIVVHCSAGIGRTGCFIATRIGC
 .|..... .    ||||.|.|.        | .. . |..  .. ||||..||.. | |  |   . .  . |. ||||||||||.|||| .|.     
alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa..nkaeaGPivvHcsaGvgrtGtyivldtll

QQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
.|....  |...|.. ..|. |  ..|| |||.||| .|
kqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 225-452 1.2e-66 219.5 In-house 10-238 (250) alignment 
Range on Protein: 225-452
Range on HMM: 10-238/250.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWP-TEEETYGPF
  |.||  |..  .||| | . ..... ||||| .. |||.. | .||||||...|. ||| ||..|... |||||.|.| .... .|||  . |.||  
keknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdv

QIRIQDMKECPEYTVRQLTIQYQEERRS--VKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGE
.. . . .|  .||.|.| .  ...  .  |... | .|||   || |   | |. .|. | .  |. .|..|.||||.||.|.|||     ..||    
tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
||.  .. .|| || ..... ||| |... .
vdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 225-453 3.9e-66 218.0 In-house 42-273 (281) alignment 
Range on Protein: 225-453
Range on HMM: 42-273/281.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQ-LREGKEKCVHYWPTEE--ETYG
  |.||. |    ..|| . . ..... ||||||.. ||.|... |||||||.|... .||.|||...||.|||.|. . .|| || .||| ..   .||
vlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke.yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkyg

PFQIRIQDMKECPEYTVRQLTI-QYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpGPIVVHCSAGIGRTGCFIATRIGCQQLK-AR
 .... .  .| ..|  |.... . . | |.|... . |||||  |...  ||   .||..  |.  .  |.|.|||||.||||..||    .....  .
dvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveael

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
 |.|.  .| .|| .|  |.||  ||.|..... 
eeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_PTPN3_pd Subfamily PTPN3 222-451 8e-66 216.8 In-house 39-270 (280) alignment 
Range on Protein: 222-451
Range on HMM: 39-270/280.0
PGHASKDRYKTILPNPQSRVCLGRAQSqedgDYINANYIR-GYDGKEKV--YIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWPTEE
|  .||.||. |||  . || |  ...    |||||||.    .... |  |||||||...|..|||.|||....|||||||.|  .|. || .|||..|
penlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete

E--TYGPFQIRIQDMKECPEYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPetAAHPGPIVVHCSAGIGRTGCFIATRIGC
.  .|| |.....  .|  .| .|.|... .|  |.|.. .. . |||||. |...  .|..| .|..    ...  |.|||||||||||| .|.  .  
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGigrtGvlilletal

QQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
. . |. .| .| || ..|  |. ..|||.||.|. ..
alieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN9_pd Subfamily PTPN9 221-458 1.6e-65 216.0 In-house 39-292 (297) alignment 
Range on Protein: 221-458
Range on HMM: 39-292/297.0
IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEET
...  .|.||. .|   ..|| | . . .|  ||||||.. ||  ..| .||||||...|||||| |||..||  ||| |.. | |. || .|||.|||.
lranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

---YGPFQIRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEES-----------PETAAHPGPIVVHCSAGIGRT
   .| ....  ...|  .|.||.|.|.   .|| |.| |  | .|||. .|.||  || .. .| |             .  ..  |||||||||||||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQ
| ||.  |  ..|.  | ||.   | .||  |  .||| |||.| . ..  || .
Gtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 211-452 2.3e-65 216.0 In-house 48-287 (319) alignment 
Range on Protein: 211-452
Range on HMM: 48-287/319.0
SNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTqlregKEKCV
 |    .  ...    |.|.  ||.  ...| | | . .|  ||||| .. ||  |.| |||.|||..||. ||| |.|. ..| ||.||     |.|| 
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncstivllt.....kdkcs

HYWPTE-EETYGPFQIRIQDMKECPEYTVRQLTIQY---QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCF
 ||| . ..... |..... ..|. ||.||.. .     ... |...   |  |||.  |... .|.|||  |.   .   |. .||||||||.|||| .
qywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

IATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
|.  .  ...|    ||.  .| .|| .|  ..|   ||.|.. .|
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Ptp69D_pd Subfamily Ptp69D 220-455 2.7e-65 215.5 In-house 44-285 (307) alignment 
Range on Protein: 220-455
Range on HMM: 44-285/307.0
DIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWP-TEE
.    | |.||. | .  . || | . . .|| |||||..|.||. | | .|| |.|. .|. ||| |... || |||||..| | .. || .|||  .|
ekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiede

ETYGPFQIRIQDMKECPEYTVRQLTIQYQE-------ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAahPGPIVVHCSAGIGRTGCFIATR
  ||   ... . .....|. |.| .  ..       ..| |    . .|.| . ||.|  ||.|. .|.| ...    .||||||||| ||.| |.|  
vqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvald

IGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
.  |||||  .|||  .|..|| .|  ..|  |||.||.. |. |
sllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 220-452 1.5e-64 213.2 In-house 21-251 (284) alignment 
Range on Protein: 220-452
Range on HMM: 21-251/284.0
DIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTqlregKEKCVHYWPTE-EE
...    |.|.  ||.  ...| | | . .|  ||||| .| ||  |.| |||||||..||. ||| |.|. ..| ||.||     |.||  ||| . ..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivi

TYGPFQIRIQDMKECPEYTVRQLTIQY---QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQ
... |..... ..|. ||.||.. .     ... |...   |  |||.  |... .|.|||  |.   .   |. .||||||||.|||| .|.  .  ..
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
.|    ||.  .| .|| .|  ..|   ||.|.. .|
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 225-452 7.2e-63 207.5 In-house 52-280 (297) alignment 
Range on Protein: 225-452
Range on HMM: 52-280/297.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGkekVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTE-EETYGPF
 .|.||| |||  .||| |   ... | ||.|| ...|.      .|.|| ||..|| ||| ||..|.|| ||||... |...|| .||. .   |.|  
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

QIRIQDMKECPEYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPE--SAGPLLRLVAEVEESPETAAHPgPIVVHCSAGIGRTGCFIATRIGCQQLKAR
 . .. ..|.  .  |.|... ..   || ||   |  |||.. ..  ||  || |. ||... .. |.  |..|||.||.|||| ...      . |  
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakre

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
 ||||.|.| .|| .|  ..|| |||.|.. ..
kevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 225-452 1.1e-61 203.5 In-house 50-275 (315) alignment 
Range on Protein: 225-452
Range on HMM: 50-275/315.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEEETYGPF
  |.||  |..  .||| |   . ... ||.|||.| ||. |.. |||.||| ...| ||| .|..|... |||||.| || |.|. .||| .. .||..
kqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGki

QIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAhpGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVD
 .  .. .   ||||| |.. .... | |  . ...||| . |... ||. |.  |    ....  |.||||||||.|||| ||.     .|..|   .|
tvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaid

ILGIVCQLRLDRGGMIQTAEQYQFLHHTL
.  .. ..|  | .|.|.||||||.. .|
vynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 223-451 4.7e-61 201.3 In-house 43-272 (315) alignment 
Range on Protein: 223-451
Range on HMM: 43-272/315.0
GHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWPT---EEE
   .|.||| |||  ..|| |   . . | ||||| ||...| ..| |||.||| . .|.|||.||.||.|. |||.|...||   ||  |||    .  
infkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

TYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpgPIVVHCSAGIGRTGCFIATRIGCQQLKA
 .| ... . ... . . ..|.|...  || | |    |  |||. ... .. ||.|. ||  . ..  .  ...||||||.|||| .|.     .|.| 
efGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef..sllvhcsaGvGrtGvvisidevvaqikr

RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
.  ||.. .| .|| .|  ..|| |.| |.. .
trsvdvfnfvknlrakrpylvqteeeyafiyda
subfamily_PTPN13_pd Subfamily PTPN13 224-451 1.6e-60 199.7 In-house 37-264 (273) alignment 
Range on Protein: 224-451
Range on HMM: 37-264/273.0
HASKDRYKTILPNPQSRVCLGRAQSqedgdYINANYIRGYDGKEK-VYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEE---
. .|.||. .||  ..|| ||   .     ||||..|.   ||.. .|||.|||.|.||.||| |||. ....|.|.|. .| || ||  ||| ...   
nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

-TYGPFQIRIQDMKECPEYTVRQLTIQYQEE--RRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaaHPGPIVVHCSAGIGRTGCFIATRIGCQQ
  .. ....  ....  ...||.|... .|    | | |. | .||||..| || .||..|||| .  .   . |||||||||||||.| .|.  .  . 
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvvlgl

LKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
..   |.|.  || .||  | |..|| .|| | ...
ierdkefdvkeivrklreqrqgvvqtkdqyifvyka
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 226-456 3.9e-60 198.2 In-house 48-283 (290) alignment 
Range on Protein: 226-456
Range on HMM: 48-283/290.0
SKDRYKTILPNPQSRVCLGRAQSQED--GDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWPTE-EETYG
 ..|...|... . |. | . ....|   .|||| || ||  ..| |||||||..||. |||...|||.|. |||||.   |||.||  |||..  ..||
llnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkayg

PFQIRIQDMKECPEYTVRQLTIQYQEE---RRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESpETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKA
.|.|.... ... ||. |.| .. ...   ..||..  ...|...   .     | ...|...  .     ..||||||...||.. |.|. .. .. | 
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt.qrkrgntsivvHCSdtvgrsavfcaaattinkckt

RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
 | .|.. .. ..|  . |..||..|||.... .  | 
egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 204-451 5.2e-60 198.0 In-house 22-271 (515) alignment 
Range on Protein: 204-451
Range on HMM: 22-271/515.0
EEFLKIPSNFVSPEDLDIPG-HASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGkEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL
|||  .|   . |. .       .|.||| |||  ..|| |   . . . ||.|| ||...|  .| |||.||| . .|.||| .|.||.|. |.|.|.|
eefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtkl

REG-KEKCVHYWPT---EEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpgPIVVHCSA
.|| | || .|||    .   .| ... .  .. | . . |.||.  ... | |    |  |||. .|. .  ||.|. ||  . .  .|  |...||||
kegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth..pliihcsa

GIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
|.|||| .|.      . |    ||.. .| ..| .|  ..|| ||| |.. .
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 221-455 2.7e-59 195.9 In-house 45-287 (325) alignment 
Range on Protein: 221-455
Range on HMM: 45-287/325.0
IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMV--WQeeVSLIVMLTQLREGKEKCVHYWPTE--
 |   .|.|.| ...  .|||.|   . . . |||||.|.| . .| .|..|.| |...|. |.| .|  |.   |..|.| .| .||..|  ||| |  
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvlneldlgkdrcavywpkemg

-EETYGPFQIRIQDMKECPEYTVRQLTIQYQEE--RRSVKHILFSAWP---DHQTPESAGPLLRLVAEVEESPET-AAHPGPIVVHCSAGIGRTGCFIAT
   |.|....... ..|  .|  |.| ..  ..   ||||   . .|.    .. | .  ..|.|| .|.|   . .   .||.||||||.|||| ||. 
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

RIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
    ...    .|||.| | .|| ||  |..|..|| .....|. .
ysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 226-452 2.6e-57 188.8 In-house 5-235 (237) alignment 
Range on Protein: 226-452
Range on HMM: 5-235/237.0
SKDRYKTILPNPQSRVCLGRAQSQedGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGK-EKCVHYWPTEE--ETYGP
 |.||  |    .||| |  | |.   |||||.|..|.||  | |||.|||. ..  |||.|||||  |.||||| | ||. .|| .|||  .  ..|| 
iknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

FQIRIQDMKECPEYTVRQLTIQYQEERRSVKHI---LFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR
. . ..  .|  .|||| |..... . . |. |    |..|||.  |. .  |||.  .. . ..  .. || ..|||||.|||| |.      .| | .
ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakek

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
  |||   |  .  ||  .||| .|| |.|.|.
kvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 226-453 1.6e-56 186.4 In-house 49-275 (287) alignment 
Range on Protein: 226-453
Range on HMM: 49-275/287.0
SKDRYKTILPNPQSRVCLGraqsQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEE-ETYGPF
 |.|.. ||.  . || |     .|. ||||| .| ||  | | .|....|| ||. .||.......|. ||||.|..|  .|.| .|||.|.  ..|..
dknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGey

QIRIQDMKECPEYTVRQLTIQYQE---ERRSVKHILFSAWPDHQ-TPESAGPLLRLVAEVeeSPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR
.|.. . .   .|..|.| .. ..   ....||   . .|...   .| .  || .   .    .     ..||||||...||.. |.|  .. .. |  
niellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkckte

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
| .|.. .. . |  . |..||.|||.|. . . 
GviDvfqvlksqriqkpgsvqtveqykfindivl
subfamily_PTPN23_pd Subfamily PTPN23 225-454 1.2e-54 180.1 In-house 44-278 (288) alignment 
Range on Protein: 225-454
Range on HMM: 44-278/288.0
ASKDRYKTILPNPQSRVCLGraqSQEDgDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEEE---TY
..|.|.. |||  ..||.|    ...| ||||| ....       .||||.|...|..||| ||... .|.||||..  |  |.|. .|||....   ..
seknrsrdilPyDhnRvklr...gskD.DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GPFQIRIQDMKECPEYTVRQLTIQYQE--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAA--HPGPIVVHCSAGIGRTGCFIATRIGCQQL
|.... ... .| ...  |.|... ..  . .||.|. . .||..  |.| . ||... |||.. |.       |.|||||||.|||| |       ..|
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel

KA-RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLAL
..  | .||. .| .|| .|  |.|. ||..|. .    
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPN14_pd Subfamily PTPN14 221-455 1.3e-54 180.3 In-house 46-295 (300) alignment 
Range on Protein: 221-455
Range on HMM: 46-295/300.0
IPGHASKDRYKTILPNPQSRVCLGRAQSQeDGDYINANYIRG-YDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWPTE--
 |  |.|.|.| .||  ..|| |  .. . . .||||  |.    |||. ||..|||...|| |||.|||...|.||||||.   .||||...|.| .  
lpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

---EETYGPFQIRIQDMKECPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESP-------ETAAHPGPIVVHCSAGIGRTG
   . ..| |..  .  .. . .. ..|....   .|.|.| |. .  ||||. ||   . |  . ||.          |.  .  |..||||||.||||
kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

CFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
  | . .  . |.   |.||  .. .||  |  ..||  ||.|....|  |
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 217-456 2.5e-54 179.0 In-house 34-277 (287) alignment 
Range on Protein: 217-456
Range on HMM: 34-277/287.0
EDLDIpghASKDRYKTILPNPQSRVCLGrAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVML-TQLREGKEKCVHYWPT
|.|     ..|.||  .||  ..|| |  |...   |||||||. .|  ... .||.|||.. || ||| .|...... ....  .. |.. || .||| 
eelaa...vkknryadvlPiddtrvlls.aegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

EEET--YGPFQIRIQDM-KECPEYTVRQLTIQYQEERR--SVKHILFSAWPDHQTPESAGPLLRLVAEV---EESPETAAHPGPIVVHCSAGIGRTGCFI
 |     | . . . |  .  |||.|| | .   | |    || . . .|||.  . .|  |.|.| .|    |    |.  ||.|||...||||.| ..
revPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

ATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
|| .  ..|.  |.||.  .| .||  | ...|.. |...|  .|. | 
atlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 224-452 2.7e-52 172.4 In-house 33-262 (283) alignment 
Range on Protein: 224-452
Range on HMM: 33-262/283.0
HASKDRYKTILPNPQSRVCLGRAQSqedgDYINANYIR--GYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGK-EKCVHYWPTE-EET
.  |.|.. |.|  | || |         ||||| .|     . ..| ||..|.|. .|| ||| ||..|... |||||.|.|.. .||  ||| .  | 
nkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed

YGPFQIRIQDMKECPEYTVRQLTIQYQ---EERRSVKHILFSAWpdhqTPESAGPLLRLV--AEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQ
||.| . ...      .....|.....   ..   . |  .  |    .  . .. .  .   .   |  |  . ||||||||.|||||. |||     .
yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

QLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
....   ||.  .|  .| .| ...|| .||...|.  
daltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN1_pd Subfamily PTPN1 222-449 5.5e-51 168.0 In-house 30-264 (290) alignment 
Range on Protein: 222-449
Range on HMM: 30-264/290.0
PGHASKDRYKTILPNPQSRVCLGRAQSqedgDYINANYIRgYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEE--
|   ...||. . |   ||. | ||.     |||||. .   .  .. || ||||.||||. ||.|||...   .||| .. | .. ||..|||..||  
penrnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

--TYG--PFQIRIQDMKECPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIG
  ..    .....   ..  .||||.| ..    .| |.. |  . .|||   ||| . .|... .| ||   . . || |.||||||||.| |.     
ellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtc

CQQLKARGE---VDILGIVCQLRLDRGGMIQTAEQYQFLH
  .......   |||   ...||  | |.||||.| .| .
lvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 226-451 6.4e-51 167.8 In-house 9-235 (239) alignment 
Range on Protein: 226-451
Range on HMM: 9-235/239.0
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEEETYGPFQ
.|.||  |.   .||| | .   .   |||||.|.| |||  | |||||| .  .  ||| |.|||   .||||| | || |.|| .|||     |  ..
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

IRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpgPIVVHCSAGIGRTGCFIATRIGCQQLKARGEV
. ..  .   .| .| . .    | | | | .  |. |||.  |. |  .| |  .. .     |.  | |.|||||.||||.|.      .| | .  |
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidamlrqakkqktv

DILGIVCQLRLDRGGMIQTAEQYQFLHHT
||.  |  .| ||  |.||.||| |.| .
difnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 226-451 6.9e-51 167.7 In-house 10-236 (239) alignment 
Range on Protein: 226-451
Range on HMM: 10-236/239.0
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEEETYGPFQ
.|.||  |.   .||| | .   .   |||||.|.| |||  | |||||| .  .  ||| |.|||   .||||| | || |.|| .|||     |  ..
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

IRIQDMKECPEYTVRQLTIQ--YQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpgPIVVHCSAGIGRTGCFIATRIGCQQLKARGEV
. ..  .   .| .| . .    | | | | .  |. |||.  |. |  .| |  .. .     |.  | |.|||||.||||.|.      .| | .  |
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidamlrqakkqktv

DILGIVCQLRLDRGGMIQTAEQYQFLHHT
||.  |  .| ||  |.||.||| |.| .
difnyvkairedrphmvqtseqyvfihla
subfamily_PTPRN_pd Subfamily PTPRN 223-452 4.3e-50 165.1 In-house 55-288 (297) alignment 
Range on Protein: 223-452
Range on HMM: 55-288/297.0
GHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE-EETY
  ..|.|.|..||  .||| | . .|.|. |||||  |   | .. .|||||||...||.|||.|||.. | .||.||.|.| | ..| .||| | .|.|
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevy

GPFQIRI-QDMKECPEYTVRQLTIQY--QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaaHPGPIVVHCSAGIGRTGCFIATRIGCQQL-
. .....  .   | .| || . ..   ..| |.|    | .||....| || .|| .   |. |        |||||||.| ||||..|.  . ...| 
hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrll

KARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
|   |.||   .  || .| |...| .|..|   ..
kGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 225-451 1.7e-49 163.5 In-house 49-274 (439) alignment 
Range on Protein: 225-451
Range on HMM: 49-274/439.0
ASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEkcvhYWPTEEETY-GPF
 .|.||| . .   .|| |          |||||||.||  ..|.|||||||  .|. ||| .|... .. |||||.| |       |||...|.. |  
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcygdi

QIRIQDMKECPEYTVRQLTIQYQ----EERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEeSPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR
 .|..   | |.|..| . .  .    |  |.| .. . ||||.. |  |  .| ..  .. | .     ||.|||||||.||||  ||  |  .|||. 
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain.sandkeeygpvvvhcsagvGrtGtiialdialeqlkle

GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
 .||| |||  || .|  |.|.  || |.. .
nkvdikgivkvlrkqrkqmvqalcqyvfiyna
subfamily_CG7180_pd Subfamily CG7180 226-453 1.3e-48 160.1 In-house 44-287 (296) alignment 
Range on Protein: 226-453
Range on HMM: 44-287/296.0
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTE-EETYGPFQ
 |.|. ...|  . || | . . .|. ||||| |. ..  |.| || |..|. .|| .||..|..||.| .|.||.  . ....  ||| . .| ||.. 
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeif

IRIQDMKECPEYTVRQLTIQYQ------------EERRSVKHILFSAWPD-HQTPESAGPLLRLVAEVEESPETA---AHPGPIVVHCSAGIGRTGCFIA
. |  .|. .. . |.. .. .             | | ||.. .  |.  .. | |.  |. |.  |.   | .    . ||.||..| | .|.| ..|
veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyla

TRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
  .  ....  .|||. . | .|| .| ..... |.|...  .| 
idanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 226-455 4.2e-48 158.6 In-house 42-292 (301) alignment 
Range on Protein: 226-455
Range on HMM: 42-292/301.0
SKDRYKTILPNPQSRVCLGRAQS--QEDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPT---EEET
  .|.| | . .. |. |   ..  .   .||||.|| ||  |.| .||.|||| .|. ||| ..||| .. |||.|.|.|| |.|| .|||.   |.|.
alnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkk.fiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

YGPFQIRIQDMKECPEYTVRQLTIQYQEE-----------------RRSVKHILFSAWPDHQT-PESAGpLLRLVAEVEESpETAAHPGPIVVHCSAGIG
.|||.. ... .  |....|||... |.                   ..|  .    ||..   .| .   |. . .|    .     ||.|||||....
fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt.vLqviddvihr.qqkigggpvvVHCSdtVs

RTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
|.| ...  ||  | || | ||. ...  .|  . |...| ||| ...  .  |
rsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0041856 (Phosphotyrosine protein) phosphatases II 226-455 1.5e-47 156.9 In-house 3-170 (182) alignment 
Range on Protein: 226-455
Range on HMM: 3-170/182.0
SKDRYKTILPNPQSRvclgraqsqeDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTqlregkekCVHYWPteeetygpfqi
.|.||. |||...||          | ||||||...|.    . .||||||...|| ||..|.... ...||.||        ...|||           
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywp...........

riqdmkecpeytvrqltiqyQEERRSVKHILFSAWPDHQTPEsAGPLLRLVAEVEEspetaaHPGPIVVHCSAGIGRTGCFIATRIGCQQlkargEVDIL
                    ... | . ..|.  |||| .|.    ||... ||.|      ..||..||||||.||||...|  . ...     .|.. 
....................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

GIVCQLRLDRGGMIQTAEQYQFLHHTLALY
 .|...|  | ||..| .||.||.  | ..
eavklvrsrRpgmvitpnqyfflqlallel
0051429 (Phosphotyrosine protein) phosphatases II 252-455 1.8e-47 157.6 In-house 4-224 (272) alignment 
Range on Protein: 252-455
Range on HMM: 4-224/272.0
GDYINANYIRGYdGK---EKVYIATQGPMPNTVSDFWEMvWQEEVSLIVMLTQLREGK-EKCVHYWP-------------TEEETYGPFQIRIQDMKECP
..||||... || |.   ........||.|.|. ||| . ... .. ||.|... | . .||  |||             ... .|| . .... .. ..
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EYTVRQLTIQ---YQEERRSVKHILFSAWPDHQTPESAgpLLRLVAEVEEspetaahPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVD--------
 |..| |..    . .| | | |... .|||| .|..|  ||.|.... .       .||..||||||..|||...|  .  ... .   ||        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

ILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
....| .||  | |..|| |||.||.. |. .
leeaveelraqrpgavqteeqylflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 216-452 6.6e-45 148.0 In-house 48-279 (290) alignment 
Range on Protein: 216-452
Range on HMM: 48-279/290.0
PEDLDIPGHASKDRYKTILPNPQSRVCLgraQSQEDGDYINANYIRGYdgkEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL-REGKEKCVHYWP
 . .|   .  |.||| .  | ..|| |   .   ||||. |||..|    . ..| |||.. .|| |.| || ||.|. |||| .|  .|| || .|.|
rkifdkntefkknrykdvvcndktrvil...kdGydGdyvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp

TEEE---TYGPFQIRIQDMKECPE-YTVRQLTIQYQEERR--SVKHILFSAWPDHQTPESAGPLLRLVAEVEESpetaahPGPIVVHCSAGIGRTGCFIA
 .|    |.| . .     ..  .    . |... ... .   .||.   .|||.  . |.  |||..  . .       .||.|||||||||||| |.|
ekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfva

TRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
  .| | |    |.|.|..|  ||  | . .|   ||  | . |
ievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 204-450 8.6e-45 147.8 In-house 24-230 (392) alignment 
Range on Protein: 204-450
Range on HMM: 24-230/392.0
EEFLKIPSNFVSPEDLD-IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQL
|||  .|.  ..|.     .    |.||| |||  ..|| |   .   | ||.|| ||...|  || |||.||| . ...|||.||.||.|. |.|.|.|
eefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtkl

REGKekcvhywpteeetygpfqiriqdmkecpeytvrqltiqYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHpgPIVVHCSAGIGR
.||                                         .. |.|    |. |||.. |. .  ||... ||.      .|  |...|||||.||
kegd......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth..pliihcsagvgr

TGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHH
||  |.      . |    ||.. .| ..|  |  |.|| ||| |.. 
tgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
0036282 (Phosphotyrosine protein) phosphatases II 252-449 3.7e-43 142.6 In-house 2-163 (174) alignment 
Range on Protein: 252-449
Range on HMM: 2-163/174.0
GDYINANYIRGYDGKEkVYIATQGPMPntvsdFWEMVWQEEVSLIVMLTQLREGK-EKCVHYWPTeeetygpfqiriqdmkecpeytvrqltiQYQEERR
 |||||... ..   .  .||.|||..     ||||.... .. .|||....| . .|| .|||.                             .. ..|
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredler

SVKHILFSAWPDHQTPESAGpLLRLVAEVEESPETaAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKaRGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
.. ..|.  ||||..|...  ||..| .|||  .   . ||..||||||.||||...|  . ...|.  . ||.| .| .||| |.||.|| .||.||.
lgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0046846 (Phosphotyrosine protein) phosphatases II 249-455 6.5e-43 141.8 In-house 9-172 (176) alignment 
Range on Protein: 249-455
Range on HMM: 9-172/176.0
QEDGDYINANYIRGYdgkekVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWPTEEETYGpfqiriqdmkecpeytvrqltiqyqe
..| ||||||.| |.      .||||||.|.|. ||.||.... ....|.||...| .  || .||| .|.                             
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

errsvkHILFSAWPDHQTPESaGPLLRLVAEVEESPETAahpGPIVVHCSAGIGRTGCFIAtrigCQQLKARGEVDILGIVCQLRLDRG-GMIQTAEQYQ
      ..|.  ||||..|..   ||.|.....|  .     ||..|||||||||||...|    .  |. .  .... .....|  |  |..|| |||.
......qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyr

FLHHTLALY
||.. . |.
flyefelll
0043147 (Phosphotyrosine protein) phosphatases II 250-449 1.3e-42 140.7 In-house 3-154 (172) alignment 
Range on Protein: 250-449
Range on HMM: 3-154/172.0
EDGDYINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLregkekcvhywpteeetygpfqiriqdmkecpeytvrqlTIQYQEER
|. |||||.|. .|    . .||||||..||..|||.|.... ...||.||.|                                       .  .. . 
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.......................................lydpelle

RSVKHILFSAWPDHQTPeSAGPLLRLVAEVEESPeTAAHPGPIVVHCSAGIGRTGCFIATRIGCqqlkarGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
|.. ..|.  |||| .| ..  ||...  ..|        ||..||||||.||||...|  . .        .... .|...|  |.|..|. .||.||.
rlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0049772 (Phosphotyrosine protein) phosphatases II 220-455 2e-39 131.6 In-house 42-279 (314) alignment 
Range on Protein: 220-455
Range on HMM: 42-279/314.0
DIPGHASKDRYKTILPNPqSRVCLgRAQSQEDGDYINANYIRGYdgkeKVYIATQGPMPNTVSDF----------WEMV--WQEEVSLIVM---------
|.. . .|.||. ||| . .||.|   .. .. |||||.|..|.    . .||||||...|| ||          |.||  ..  |  |||         
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTQLREGKekcvH-----YWPTEEetygpfqiriqdmkecpeyT-------VrqltiqyqeERRSVKHILFsAWPDHQTPeSAGPLLR
            |..| ..           .... .                   .       .         ||. .|.. .  .||...| .   ...
lsrLdaAlgKtpllildgng....neptaadlellk...................eelydpelf.........erlgikylri.pvpDgsap.lledfde

LVAEVEESpetaAHPGPIVVHCSAGIGRTGCFIATRIGCQQLkargEVDILGIVCQLRLDRG-----GMIQTAEQYQFLHHTLALY
... .||       .||..|||.||.||||.|... . . .|     |..  .. ..|| |      |.|.. |||.| .. |  |
flefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 219-452 1.1e-38 127.6 In-house 32-265 (281) alignment 
Range on Protein: 219-452
Range on HMM: 32-265/281.0
LDIPGHASKDRYKTILPNPQSRVCLGR-AQSQEDGDYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTE
.. |    |.||  |     ||| |      ..  ||| |||||    | . || ||||  .| .||| |.|||. . |||| |. |  .|||  |.| .
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

EET---YGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEespetaAHPGPIVVHCSAGIGRTGCFIATRIGC
      .  . .  .|          .| . |. | | . | |.  ||| | |||.  .|... ..       |.  | |.|||||.||.| ..|  |  
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir......arstppvihcsagvgrsgtlmaveial

QQLKARGE-VDILGIVCQLRL-DRGGMIQTAEQYQFLHHTL
| ....    ||  || .||.  |   .|| .|| .. . |
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_ptpA1_pd Subfamily ptpA1 223-415 3.3e-37 123.2 In-house 46-255 (418) alignment 
Range on Protein: 223-415
Range on HMM: 46-255/418.0
GHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDgkEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE-----
  .||.||  |||  ..|| | . | .|  |||||||| |     | .|.||||.|||..||| |||.. . .||||..  |  . || .||| .     
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay..pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

-------EETYGPFQIRIQDMKECPEYT--VRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPE----TAAHPGPIVVHCSAGIGRT
       .| .| . . . .. . ||     |.. . .. | | . .  .  ||||. |. . |. .|.  . .  .    .. .  ||.||||||.|||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GCFIATRIGCQQ
| | .. |  ..
gtfctavimmkk
0051082 (Phosphotyrosine protein) phosphatases II 252-451 3.9e-36 119.3 In-house 3-148 (151) alignment 
Range on Protein: 252-451
Range on HMM: 3-148/151.0
GDYINANYIRGYdgkekvYIATQGPMPntvsDFWEMVWQEEVSLIVMLTQLREGKeKCVHYWPTEEetygpfqiriqdmkecpeytvrqltiqyqeerRS
 ||||..|. |.      .....||..    ||.|..... .. ||.|... | . .| .|.| ..                                . 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg................................ie

VKHILFSAWPDHQTPESAGPLLRLVAEVEEspetaAHPGPIVVHCSAGIGRTGCFIATRIGCQQlkargeVDILGIVCQLRLDRGGMIQTAEQYQFLHHT
|.|| .  |||...|.|   .|... ....       .||..||||||.||||...|  . ...      |..  .. ..|| |.|..|. .|..|... 
vlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 268-449 4.7e-36 119.1 In-house 9-143 (152) alignment 
Range on Protein: 268-449
Range on HMM: 9-143/152.0
KVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWpteeetygpfqiriqdmkecpeytvrqltiqyqeerrsvkHILFSAWPDHQTP
. .||||||.|||..|||.|...  .. |||||.| |  |.|| .|.                                        ..|.  |||| .|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhgvp

ESAGPLLRLVAEVEESpeTAAHPGPIVVHCSAGIGRTGCFIATRIGCqqlkarGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
...  || |.  .|.        ||..||||||.||||...|  . .        |... .| ..|  | |.... .|..||.
dlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 226-457 3.4e-35 116.3 In-house 35-260 (267) alignment 
Range on Protein: 226-457
Range on HMM: 35-260/267.0
SKDRYKTILPNPQSRVCLGRAQSQedgdYINANYIRGYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGkeKCVHYWPTE---EETYGP
 ..|.   ||  ..|| |   . .    |||| |. ||  | . .|.||.|. ||..||.... ...|. ||.||.  ..  .   .|| .    . |  
ernrlddnlpyddtrvilrtkeee....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftd..nirlfwPPkmgqakkyqd

FQIRIQDMKECPEYTVRQLTIQYQEER-RSVKHILFSAWpdhQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGE
. .     ||  .| .  | .....|  . |    .  |   .      | |. .  .    .      |.||.||.|.||.| |.      ...|  | 
ltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegv

VDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAG
.||   . ..|  | |...| |.| ..|..|| || 
sdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 224-455 1.4e-34 114.5 In-house 41-276 (307) alignment 
Range on Protein: 224-455
Range on HMM: 41-276/307.0
HASKDRYKTILPNPQSRVCLGRAQsqEDGDYINANYIrGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEE---T
 . |.||. .    ..|. .         ||| |||. |   | | .|..|||. ||. .|| |. ||.|  ..|| .. | .| ||  ||| ||    .
ntdknryqdvkcqdkgrivvkfdg..lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YG--PFQIRIQDM---KECPE---YTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEEspetaaHPGPIVVHCSAGIGRTGCFIATR-
.|  |  | ....   | .|.     | .| ... .. |...|. .. |||. .|.     . |.  |.       .  |.|||||||.||.|  .|   
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvGrsGtivaisl

IGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
.  . ..     |.  .| .|| .|   |||  || .||  |  |
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 248-455 7.8e-34 111.9 In-house 55-269 (285) alignment 
Range on Protein: 248-455
Range on HMM: 55-269/285.0
SQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPT---EEETYGPFQIRIQDMKECP--EYTVRQL
 . | ||| |...|     .  ||.||||.|.|.|||| |..||... ..||  | ||  |||  |.|    |   .| ..| . . ||       .  |
knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnal

TIQYQEERRS----VKHILFSAWPDHQTPESAGPLLRLVAEVEESpetAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGG
|.   |.  |    ..|.    |||. .|| | |.. |   |..      .  ||.||||||.|||  |.       ..    ....| || ..|  |  
tvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfq

MIQTAEQYQFLHHTLALY
 .|.  |. ||.  |  |
avqshmqflflyvvlmey
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 226-448 8.7e-34 111.6 In-house 52-273 (301) alignment 
Range on Protein: 226-448
Range on HMM: 52-273/301.0
SKDRYKTILPNPQSRVCLgraQSQEDGDYINANYIRGYdGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEE---ETYG
 |.||.|.  .|.. | .    ..     | ||.|    |. . .||||||..||  ||| |. | .|  ||||.| .|  .||| .| |..       |
dkhryptvPckPstavev...ivdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

PFQIRIQDMKECPEYTVRQLTIQYQE-----ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaahpgPIVVHCSAGIGRTGCFIATRIGCQQL
 |.|.|....   .  . . |.. ..     . |.| |  .| |.|...|.|   |  |.  | .| .      ||||||||||||. .||.|..  ...
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylarev

KARGEVDILGIVCQLRLDRGGMIQTAEQYQFL
.|  ....   . .|| .|   .|| .|  ..
eadptieltealkhlrehrwngvqtnsqlywm
0044763 (Phosphotyrosine protein) phosphatases II 236-450 4.4e-33 109.8 In-house 2-165 (178) alignment 
Range on Protein: 236-450
Range on HMM: 2-165/178.0
NPQSRVCLGRAQSQEDGDYINANYIRGYdgkekVYIATQGPmpntvSDFWEMVWQEEVSLIVMLTQLREGK-EKCVHYWPTEEEtygpfqiriqdmkecp
 . .||.|   .  | .|||||..| ..     .|.....|     .|..|..... ...||.||.  |.  .|| .|||.|..                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eytvrqltiqyqeerrsvKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaAHPGPIVVHCSAGIGRTGCFIATRIGCQQlkargEVDILGIVCQLRLD
                   . |.  .||| .|..   .|..|. .||  .   ..||..||||||.||.|...|  . ...      ...  .. ..|  
..................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RGgMIQTAEQYQFLHH
|  .... .|...|. 
Rp.ivpnpgqlrqLye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 223-379 7.6e-33 108.6 In-house 32-193 (297) alignment 
Range on Protein: 223-379
Range on HMM: 32-193/297.0
GHASKDRYKTILPNPQSRVCLGRAQSqeDGDYINANYIRGYDGKEK-VYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE---E
.   |.||. ||   ..|| | |. .  . |||||.|.   | ...  || .|||. .|| |||..|....|  |||...|.| |..||. |||      
sslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

ETYGPFQIRI--QDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEV
 . | . .    .   |     . .|.. |..|.| |.|. | .||||  |     | |. |.|
lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
PTPc_DSPc_SM00012 352-453 8.6e-33 108.1 In-house 2-104 (105) alignment 
Range on Protein: 352-453
Range on HMM: 2-104/105.0
VKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR-GEVDILGIVCQLRLDRGGMIQTAEQYQFLHH
|||. ...||||..||.. ..|.|...|... . ... .|.|||||||.||||.|.|  | .|||... .||||. ||..||  | ||.|| |||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLA
 |.
all
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 225-454 2.1e-32 107.0 In-house 56-287 (305) alignment 
Range on Protein: 225-454
Range on HMM: 56-287/305.0
ASKDRYKTILPNPQSRVCLGRAQsqeDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQ-LREGKEKCVHYWPTEEETY---
 .|.||. .  . || | | . .     ||| |||.      || .|..|||. .|. .|| || |. |  |||| . .  || || .|||.        
itknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

-GPFQI----RIQDMKECPEYTVRQLTIQY-QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESpetaahPGPIVVHCSAGIGRTGCFIATRIGCQ
 .   .      . |.  .|  .  | . |  ... ||.|. .. |||   |      | |.. .  |        ||||||||||||||  .|     .
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs......kvpivvhcsagigrtgtivaieyile

QLKARGEV-DILGIVCQLRLDRGGMIQTAEQYQFLHHTLAL
..    ..  .  .|  || .|   ||.  || |.|  .  
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_CG42327_pd Subfamily CG42327 202-382 4.7e-32 105.9 In-house 7-193 (319) alignment 
Range on Protein: 202-382
Range on HMM: 7-193/319.0
LEEEFLKIPsNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQ
. ||| ..| ....  |   ..   |.|.  ..| |..|| | |  ...   |..|.|.||||  .  |||.| .. .. |||| .||.     || ||.
vaeefrdlP.qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LREGK-EKCVHYWPTEE-----ETYGPFQIRIQDMKECPEYTVRQLTIQY--QEERRSVKHILFsAWPDHQTPESAGPLLRLVAEVEES
| |   ..| .|.||.|     ..|| ... ... .   .| .  | ..   .|| | . |  .  |.. . | .  .|. .. ||..|
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 223-458 3.2e-31 103.5 In-house 18-261 (290) alignment 
Range on Protein: 223-458
Range on HMM: 18-261/290.0
GHASKDRYKTILPnPQSRVCLGRAQSQEDGDYINANYIRGYDGKEkvYIATQGPMPN-------TVSDFWEMVWQEEVSLIVMLTQLREGKEK-----CV
.|. . |..  |   ..|| |    ..   ||| ||..   .| .   |.|| |  .       |. .|| |. ||.|  .||| .  | ...     | 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

HYWPTEEE---TYGPFQIRIQDMKECPEYTVRQLTIQYQEER-RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESpETaahpgPIVVHCSAGIGRTGCF
.| |....   ... .... ... .  .  .|.|......|.   |.| |.. | . ...|.   || |.  |. | .|     |..|||  || |  ..
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.kt.....pvivHcvdGiSrsAal

IATRIGCQQLK-ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQ
 |  .|.| .   .|.| .  .. .||  |  .|..|... |    . |.| .
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 226-456 8.5e-31 101.6 In-house 54-290 (310) alignment 
Range on Protein: 226-456
Range on HMM: 54-290/310.0
SKDRYKTILPNPQSRVCLGRAQSQeDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQ-LREGKEKCVHYWPTE--EETYGp
 |.||  ..   .||| |   .|.  .||| |||..      . .| .|||.  |. ||| |..||    |..| .  .||. ||| |||.    |||| 
hknrysdvvcldtsrvklkidksr.yedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg.

fQIRIQDMKEC-PEYTVRQLTIQYQEE------------RRSVKHILFSAWPDHQTPESAGPL--LRLVAEVEEspetaahpGPIVVHCSAGIGRTGCFI
  ||. .. |   |. . .|.. .  .               |. | .  |||   |.        ||.|.|          || |||||||..|... .
.cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh........gpcvvhcsagkdrlyvvv

ATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYA
| ..  ..|.   .||.  .. .|. .|   |||  || ....   ..|
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 224-455 5.6e-30 99.1 In-house 48-286 (305) alignment 
Range on Protein: 224-455
Range on HMM: 48-286/305.0
HASKDRYKTILPNPQSRVCLGRAQsqeDGDYINANYIRGyDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEETYGP
.| |.||| .    . || |  .      .|| |||.     . | .| || |. .| .||| | .|. |  | || .| | | .||..|......    
eagknrykdvgcldnnrvklegpw...pheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FQIRIQDMKEC------------PEY--TVRQLTIQY-QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEveespeTAAHPGPIVVHCSAGIGRTGCFI
|. . | .                .   |  .|.|.   |. | |.|  .  |||   | .   .| |...      . .  |||||||||||||||  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek......arpskgpivvhcsagigrtgsvv

ATRIGCQQLKARGEVD-ILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
     ..|| |   ..    |. ..| .|   ||| .|| |.|  .  |
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 225-452 6.8e-30 99.1 In-house 44-267 (288) alignment 
Range on Protein: 225-452
Range on HMM: 44-267/288.0
ASKDRYKTILPNPQSRVCLGraqsqEDGD-YINANYIRGYDGKEKvYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEETYGP
...|||. .     .|| |      .| | ||.|| .     |..  | .| |.  |.  .|.|. ...|  ||||..| | ||||  .|.|..      
ptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrr.licaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FQIRIQDMKECPEYTVR-----QLTIQYQ-EERRSVKHILFSAWPDHQTPESAGPLLRLVAEVeespetAAHPGPIVVHCSAGIGRTGCFIATRIGCQQL
..   ...|.  .   .      | |. . ||.  ||.. .  |.|.  ||.  . |||.  .       ..  |||||.|||.|||| .| . |  ..|
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialesl

KARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL
.    . |  .. .|| .|   |||  || ..|  .
rlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_egg_pd Subfamily egg 226-455 2e-28 94.0 In-house 42-269 (307) alignment 
Range on Protein: 226-455
Range on HMM: 42-269/307.0
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGkEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGkEKCVHYWPTEEETYG---P
 | | | .  .  ||| |   . |  .|.| ||...|       .| .| |. ||| ||| ||.||||  |||||  .|  |.| .|||  |.      |
ekarskrvhckdssrvklelrrGqylddfihanrvkGkpl.lnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvp

FQIRIQDM----KECPEYTVRQLTI-QYQEERRSVKHIlfsAWPDHQTPESAGPLlRLVAEVEESPEtaahpgPIVVHCSAGIGRTGCFIATRIGCQQLk
  .||. .    |  | ..| .| .   ..| | ..|     .  ... .   || |..  . .  .      |.||..  |. ......|  |   .| 
GslrienlkvdskadplfrvtklklvGgddeerflehw...qgdvnnssdvyspl.rvlrklrnlsk......pvvvqdilGvskaatlvaieiallsl.

ARGEV---DILGIVCQLRLDRGGMIQTAEQYQFLHHTLALY
 || .    .|  |  ||| |   .... .| |..  ....
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 267-449 1.6e-26 87.7 In-house 4-197 (199) alignment 
Range on Protein: 267-449
Range on HMM: 4-197/199.0
EKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWPTEEE---TYGPFQIRIQDMKECPEYTVRQLTIQYQ----EERRSVKHILFS
.. ||||| |. .|..|||.|||.     |||. . .  ||     |||| |     || . .  . .   |.||.  | .  .       | . |  |.
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHQTPESAGPLLRLVAEVEESPET-AAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK--ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
.| .. ||. |  .  .||  | |      .  |..|||| | | || |.|  || .  .      ||.. .  .||  | |.| . ..|.|..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 268-449 1.7e-26 87.6 In-house 4-196 (198) alignment 
Range on Protein: 268-449
Range on HMM: 4-196/198.0
KVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWPTEEE---TYGPFQIRIQDMKECPEYTVRQLTIQYQ----EERRSVKHILFSA
. ||||| |. .|..|||.|||.     |||. . .  ||     |||| |     || . .  . .   |.||.  | .  .       | . |  |..
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHQTPESAGPLLRLVAEVEESPET-AAHPGPIVVHCSAGIGRTGCFIATRIGCQQLK--ARGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
| .. ||. |  .  .||  | |      .  |..|||| | | || |.|  || .  .      ||.. .  .||  | |.| . ..|.|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 226-334 1.7e-24 81.2 In-house 49-169 (350) alignment 
Range on Protein: 226-334
Range on HMM: 49-169/350.0
SKDRYKTILPNPQSRVCLG--------RAQSQEDGDYINANYIRGY----DGKEKV-YIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVH
.|.||| |||  .||| |         .  | .  |||||||..      . . .  |||||.|.|.|| ||.... . .| .|..||.. | . ||| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPteEETYGPFQIRIQDMKECP
||.  | .|  .........| .
YWq..egsydditvklaskweni
0048076 (Phosphotyrosine protein) phosphatases II 324-452 3.8e-24 80.4 In-house 19-139 (145) alignment 
Range on Protein: 324-452
Range on HMM: 19-139/145.0
QIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETaahPGPIVVHCSAGIGRTGCFIATRIGCQqlkaRGeVD
 .... .|.   .||  ||   . . | . ..|.  ||||..|...  ||.... .||  .    .||..||||||.||||...|  .  .    .| |.
aldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vs

ILGIVCQLRLDRGGMIQTAEQYQFLHHTL
.  .. ..|  | |.... .|..||.  .
leealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 326-450 1.4e-22 75.4 In-house 21-139 (144) alignment 
Range on Protein: 326-450
Range on HMM: 21-139/144.0
RIQDMKECPEYTVRQLTIQYQEERRS--VKHILFSAWPDHQTPESAGPLLRLVAEVEESPEtaaHPGPIVVHCSAGIGRTGCFIATRigcqQLKARGeVD
... .|.   .||  || .|  |     . ..|.  ||||..|...  ||.... .||  |   ..||..||||||.||||...|       .| .| ..
dlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.ls

ILGIVCQLRLDRGGMIQTAEQYQFLHH
.  .. ..|  | |.... .|..||. 
leealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 264-448 3.1e-22 73.4 In-house 84-280 (302) alignment 
Range on Protein: 264-448
Range on HMM: 84-280/302.0
DGKEKVYIA---TQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKE-KCVHYWPTE---EETYGPFQIRIQDMKE-CPEYTVRQ----LTIQYQE----
|| ||.         |  .|.  .| .. | .|...| |... |..| || .|. ..   | ..| . ..  ..|.   |.| ..     |.....    
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

--ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEeSPETAahpgpIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQY
   ...|. ..||||||| .|. | . | ..   | |  ..     ..||||||.|||| ..| . | |  . .   |.| ||. .|  | | .|...| 
kkvkktvdilafsawpdhGapkeaytaldilkfce.sykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

QFL
 .|
iyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 348-452 4.5e-21 69.7 In-house 87-190 (440) alignment 
Range on Protein: 348-452
Range on HMM: 87-190/440.0
ERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAhPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQF
| |..|.  . .|||.  |. |||.|... .|.|| | |.  ||..|||||| ||||  ||     .. |   ..||. ..  .| .|  |.|| ||| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LHHTL
.|...
vheav
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 272-447 7.2e-20 66.1 In-house 39-212 (255) alignment 
Range on Protein: 272-447
Range on HMM: 39-212/255.0
AtqgpmpnTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTEEETYGPF-QIRIQDMKECPEYTV--RQLTIQYQE--ERRSVKHILFSAWPDHQT
        ||  |.... | . . .|||. . | |.||| .|.|.| .    . .. .   |   .  .  ...| .. |  . . |||  .  |.....
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PESAGPLLRLVAEVEESpEtaahpgPIVVHCSAGIGRTGCFIATRIGCQ------QLKARGEVDILGIVCQLRLDRGGMIQTAEQYQF
|| |  .| ..  | .|        ..|||||.||||.  |. . .  |      .    .|.| | .. .||  | . |.|  |  |
Pelareilnilkvvrds.k......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 191-449 8.5e-20 65.7 In-house 10-269 (312) alignment 
Range on Protein: 191-449
Range on HMM: 10-269/312.0
ALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLgraqSQEDGDYINANYIRGYDgKEKVYIATQGPMPNTVSDFWEMVWQ
|      .|.||  |.  .   .   |   .      .||  |    . |  |    . ..  || ||...    | . ...||||. ||.. ||...  
asavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftl....agdenfyihanfvkict.kperfvctqgplentcthfwqlals

EEVSLIVMLT-QLREGKEKCVHYWPT--------EEETYGPFQIRIQ---DMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAE
   . |..|.  . .| |||..|           .   |  .   |.     |.   . | .. ..   .   ..|  ...||||  |.|    |||.. 
lgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsa

VEESPEtaahpgPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
|           |.. |||||.|||| ..        |.     ..  .   || ||   ...  || .  
vkkdkk......pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyal
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 249-456 1.2e-19 64.8 In-house 72-285 (302) alignment 
Range on Protein: 249-456
Range on HMM: 72-285/302.0
QEDGDYINANYIRGYDGKEKVYIaTQGPMPNTV---SDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQ-IRIQDMK--ECPEYTvRQLT
.|  .|.||  .   . ...... .| |  ...    .|| ||.||..  .|.| .  | |.   ...|.. ..|  .. ...   |  .  | .  ...
aepdsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryv

IQYQEERRS----VKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAahPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGM
|    |  |    ..  ... |.... |.. . | . .|.| .. . |    ..|.    |.|| | |..  .  ..|..  |. |  || ..| .|  .
iEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkika..dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpra

IQTAEQYQFLHHTLALYA
.....|| .|. .|.|| 
vdslkQyvslyialllyi
subfamily_CG42327_pd Subfamily CG42327 387-458 2.2e-18 61.0 In-house 245-317 (319) alignment 
Range on Protein: 387-458
Range on HMM: 245-317/319.0
AHPGPIVVHCSAGIGRTGCFIATRIGCQQLKAR-GEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQ
 . ||.||||| |.||||  ||. |  ..|.     |||  .| ..| ||.  ..| |||.|....|  || .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 226-331 1.3e-16 54.9 In-house 50-169 (349) alignment 
Range on Protein: 226-331
Range on HMM: 50-169/349.0
SKDRYKTILPNPQSRVCLGRAQ--------------SQEDGDYINANYIRGYD-GKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKC
.|.||| |||   ||| | ..               |    |||||||..      || ||||| |.| || ||....  ..| |.. |..  | . |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

VHYWptEEETYGPFQIRIQDMK
  ||  .| .|  .....|.  
diyw..qelsysnitvklqnss
subfamily_hpo-7_pd Subfamily hpo-7 277-447 6.8e-16 53.0 In-house 43-218 (263) alignment 
Range on Protein: 277-447
Range on HMM: 43-218/263.0
MPNTVSDFWEMVWQEEVSLIVMLTQLREG-KEKCVHYWPTEEETYGPF-QIRIQDMKECPEYTVR--QLTIQYQ--EERRSVKHILFSAWPDHQTPESAG
. .|.  |.... | . . .|||.   |  .||| .|.|.| .    . .. .   |   .  ..  .|. . .   . . |||  .  |.... || | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLLRLVAEVEESpEtaahpgPIVVHCSAGIGRTGCFIATRIGCQ------QLKARGEVDILGIVCQLRLDRGGMIQTAEQYQF
  |...  . .|        ..|||||.||||.  |  . .  |      .    .|.| | .. .||  | . |.|  |  |
eilnilkvarns.k......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 262-352 6.2e-15 49.4 In-house 231-320 (440) alignment 
Range on Protein: 262-352
Range on HMM: 231-320/440.0
GYDgKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREgkEKCVHYWPT--EEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSV
||  | . .|||| |.  || ||| .| . ..| |.|| || .    |  |||      |.||| .  .  ..     || | ..|.||   .
gys.kknafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevhei
subfamily_eak_pd Subfamily eak 232-367 2.4e-12 40.9 In-house 59-196 (332) alignment 
Range on Protein: 232-367
Range on HMM: 59-196/332.0
TILPNPQSRVCLGRAQSQEDGdYINANYIRgYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLT-QLREGKEKCVHYWPTE---EETYGPFQIRI
 |.|. .  | |  .|  ..| ||||  .  .    . || |  .  . |  ||.|| ..    ||.|  .. .. ||   |.| .   |  .| ...  
kivpydrylvrltssqlnrlG.yinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

QDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPE
..  .   . .|.| ..  .|   |.|  .  | . ..| 
kefvkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 387-450 3e-11 37.7 In-house 224-289 (297) alignment 
Range on Protein: 387-450
Range on HMM: 224-289/297.0
AH--PGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHH
..  . ...||||||.||.|  . . .  ..|. .   |.  |. .||  |  ..|| ||...|..
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 393-453 8.2e-11 36.1 In-house 1-61 (69) alignment 
Range on Protein: 393-453
Range on HMM: 1-61/69.0
VVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
|||||.| |||| |||  .   ..|.   |||.  |  .|  |  |.   ..| |.| .|.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 392-453 8.3e-11 36.1 In-house 1-62 (69) alignment 
Range on Protein: 392-453
Range on HMM: 1-62/69.0
IVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLA
.|||||.| |||| |||  .   ..|.   |||.  |  .|  |  |.    .| |.| .|.
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 228-299 2.8e-10 34.3 In-house 41-116 (347) alignment 
Range on Protein: 228-299
Range on HMM: 41-116/347.0
DRYKTILPNPQSRVCLGRAQ-----SQEDGDYINANYIRgYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVML
.| |    . ..|| |   .     ...   |||| .|. .|  .| || || |.|.|| ||| ||    |. .| .
nrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 241-448 3.9e-10 33.8 In-house 57-271 (303) alignment 
Range on Protein: 241-448
Range on HMM: 57-271/303.0
VCLGRAQSQ-EDGDYINANYIRgYDGKeKVYIATQGPMPNTVSDFWEMVWQEEVSLIVML-TQLREGKEKCVHYWPTEEE--TYGPFQIRIQDMKECP--
.||  .. .  |  || |.|.   | . |  | || |.. | .|||.|. .. |  ...| |.    |      .| ...   .    ||. ..|.    
icldhskvklsdssyihasyle.ldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelg

-EYTVRQLTIQYQEeRRSVKHI-LFSAWPDHQTPESAGP-LLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGcqQLKARGEVDILGIVCQL
  .... |..   .  .|  |.  . |||  . |  . | ... . ...      ..  | |    .| ||.| |        .|    |   | .|  |
dgwvlkvlsvsngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta..hlslhseqasldlvkcl

RLDRGGMIQT---AEQYQFL
   | | ...     |. ..
envrngrlhavqnlsqfsvv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 352-455 2.7e-09 31.2 In-house 217-343 (350) alignment 
Range on Protein: 352-455
Range on HMM: 217-343/350.0
VKHILFSAWPDH---QTPESAGPLLR----LV-AEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQ-------------QLKARGE--VDILGIV
| .. .  |.|      |||  . |     |.   . ||    |.  ||.||||||.|||| ...     .             .|.   .    |  ||
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

CQLRLDRGGMIQTAEQYQFLHHTLALY
 .||  |  |.|. .|. |....|  |
nelrkqrismvqnldqfifiYeallfy
0038934 (Phosphotyrosine protein) phosphatases II 355-449 5.8e-09 31.3 In-house 82-170 (194) alignment 
Range on Protein: 355-449
Range on HMM: 82-170/194.0
ILFSAWPDHQTPESAGPLLRLVAEVEESPEtAAHPGPIVVHCSAGIGRTGCFIATRIgcqqlKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLH
.|   .||. |. |   ||| .  |.|  . .  .| ..||| ||.||||...|  .       |   .    .  .|  |.|.|.. .... |.
ylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 250-317 1.6e-08 28.9 In-house 11-73 (130) alignment 
Range on Protein: 250-317
Range on HMM: 11-73/130.0
EDGDYINANYIrGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEkcvhYWPTEE
.. .||||... |  |. . |. || |. .|  ||| |. .  | ..|.|  . |  |    |||  |
qgntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede....ywpdse
subfamily_CDC14_pd Subfamily CDC14 389-450 7.1e-08 26.6 In-house 263-318 (328) alignment 
Range on Protein: 389-450
Range on HMM: 263-318/328.0
PGPIVVHCSAGIGRTGCFIATRIgcqqLKARgEVDILGIVCQLRLDRGGMIQTaEQYQFLHH
 | |.||| ||.||||..||. .    .|   ..    ..  ||. | |.. .  | .|| .
eGaiavhCkaGLGrtGtLiacyl....mkhy.rftaaeaiawlricrPGsvig.pqqkflee
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 268-447 8.7e-08 25.1 In-house 116-300 (346) alignment 
Range on Protein: 268-447
Range on HMM: 116-300/346.0
KVYIATQGPMPN--TVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYG---PFQI--RIQDMKE-CPEYTVRQLTIQYQEERRSVKHiLFSA
|. .|    | |   | ||| |..||.. |. ..      |.     .  |.  |     . |  |  |.     |||.  |     .      |   . 
klivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvh.hhap

WPDHQTPESAGPLLRLVAEVEeSPETAAHPGpIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQF
|   | |  . |..... .   | .     | . |    | ||. .|| .    .||    | .|. |. ... .| | ...  ||  
wkhlqqppktlpiikmihqfl.sekqvqnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyas
PTEN_1 345-408 1.6e-07 26.3 In-house 88-149 (196) alignment 
Range on Protein: 345-408
Range on HMM: 88-149/196.0
YQEERRSVKHILFSaWPDHQTPESAgPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIA
...... |... |. ..||..|  .  |.. .....|.   . . . ..||| ||.||.|. .|
eeffksgveylhfp.ieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 200-265 1.8e-07 24.9 In-house 22-88 (440) alignment 
Range on Protein: 200-265
Range on HMM: 22-88/440.0
KQLEEEFLKIPSNFVSPEDLDI-PGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDG
.  |.|.  .|| ...| |    |    |.||. ||   .||| |   ..  | ||||| || | . 
rafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_PTPDC1_pd Subfamily PTPDC1 351-450 3.5e-07 24.8 In-house 82-170 (182) alignment 
Range on Protein: 351-450
Range on HMM: 82-170/182.0
SVKHILFsAWPDHQTPeSAGPLLRLVAEVEespeTAAHPGPIVVHCSAGIGRTGCFIATRIG-CQQLKARGevdilgIVCQLRLDRGGMIQTAEQYQFLH
 . .  | .|.|.... |   .| .|  |.     | . | . ||| || ||||  ||. .   ..|.|         .  .|  |   ||| || ....
giyvynf.gwkDygva.sleriLdivkvva....falqegkvavhChaGlGrtGvliacylvyakrltaek......aiklvrskrpksiqtreqvelvk

H
.
e
subfamily_CDKN3_pd Subfamily CDKN3 332-450 1.4e-06 22.0 In-house 82-190 (202) alignment 
Range on Protein: 332-450
Range on HMM: 82-190/202.0
ECPEYTVRQLTIQYQEERRSVKHILFsawPDHQTPESAGpLLRLVAEVEESPETAAHpgpIVVHCSAGIGRTGCFIAtrigCQQLKARGEVDILGIVCQL
|   | ||.|  .||.   .|.|  .   .|  .|. |   |... |.  . ..  .    .|||  |.||.   ||    |  |     ..    . .|
elskyrvrrlldlyqqaglivhhypi...adglvpdias.clkileelrinlkayrk...tlvhcygglgrsslvia....clllylddtiepkdaidkl

RLDRG-GMIQTAEQYQFLHH
|  .| . |||  ||..|..
rdlkgsraiqtvkqynylse
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 265-317 1.6e-06 21.9 In-house 134-182 (244) alignment 
Range on Protein: 265-317
Range on HMM: 134-182/244.0
GKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEkcvhYWPTEE
|.   || || |. .|  ||| |. .  | ..|.|  . |  |    |||  |
grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....ywpdse
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 225-275 2.2e-06 21.8 In-house 49-95 (95) alignment 
Range on Protein: 225-275
Range on HMM: 49-95/95.0
ASKDRYKTILPNPQSRVCLGraqSQEDGDYINANYIRGYDGKeKVYIATQG
  |.|.  |.|   .||.|    .. | ||||| .. ||  | ..|||.||
ipknrflnifpydatrvvlt...tkrdsdyinacfvdgyark.ncyiaaqg
subfamily_DSP23_pd Subfamily DSP23 373-450 6.1e-06 21.0 In-house 74-140 (148) alignment 
Range on Protein: 373-450
Range on HMM: 74-140/148.0
LRLVAEVEESPETaahpgpIVVHCSAGIGRTGCFIAtrigCQQLKARGeVDILGIVCQLRLDRGGMIQTAEQYQFLHH
.|.| | ||  |.      . |||  | |||| ..|    |  .| |. .     . ..|  | | ..| || . ...
vrvveeaeeknea......vsvhcllgrgrtgtmla....cylvkerk.laaaeaiaevrrlrpgsvetveqeklvrd