Gene PTPRR in Homo sapiens

Synonym: EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, PTPRR

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP084_AA protein Get Run
HsapP084_AA_375-647 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 389-652 1.6e-131 432.4 In-house 3-272 (274) alignment 
Range on Protein: 389-652
Range on HMM: 3-272/274.0
SSHLLQSEFMEIPMNFvDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVI
|.. |..||.|.|.|| |..|.|.... |||||||||||. |||.|......|..|.|||||||.||....||..|||||..|||.|||.|..||...||
sfkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMITKLKEKNE-KCVLYWPEKRGI-----YGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGR-
||.|||||.|| ||. |.|.....     ||.||. | ...|...|..|.||||. .....|||||||.|||||.||.|..||.|.|.|||.| ... . 
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLS
.||||||||||||||||||.||...||.||.||| |.|||.||.|||||||||||||..|.|||||..||.
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
0039614 (Phosphotyrosine protein) phosphatases II 362-648 3.3e-92 304.4 In-house 3-289 (297) alignment 
Range on Protein: 362-648
Range on HMM: 3-289/297.0
PREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKA
|... ..|. .   ..|.. .|..   |..||. ||.|.. ...| ..   | ...||||| |||.. |||.| |.. .|  |.||||.|. ||.   ..
plrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

FIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSA
|||||||. .||.|||.|||.....||||.|||.|.. ||. ||||. | ||.. | ...| ..|.||.|.| .. .. . .|.|..||.||||..|.|.
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

QPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
. ||...  |.| . .... |||.||||||.||||.|||  . ..||..|| ||.|..|..||. |.|.||| .||.|...||. . 
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRD_pd Subfamily PTPRD 391-645 9.7e-90 296.8 In-house 23-278 (564) alignment 
Range on Protein: 391-645
Range on HMM: 23-278/564.0
HLLQSEFMEIPMNFVDPKE-IDIPRHGTKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIV
  ...|. .| ..   ..|  . |    ||||. |..   |||.|.. . . . | ||||..| ||  |.||.||||||. .|..|||.|||...| .||
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiV

MITKLKEKNE-KCVLYWPEK-RGIYGKVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVV
|.|||.||.. ||  ||||| .  ||...| . . .|  .|.||.. ||.   |... |... .||||||  |.||..||.|. .|.. .  ....||.|
mltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPiv

VHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
||||||.||||.||. ..  ...|||..||  ..| .|| .|  |||| ||| |.|.|. 
VhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
0050432 (Phosphotyrosine protein) phosphatases II 388-648 1.7e-89 295.5 In-house 39-299 (308) alignment 
Range on Protein: 388-648
Range on HMM: 39-299/308.0
ASSHLLQSEFMEIPMNFVDPK--EIDIPRHGTKNRYKTILPNPLSRVCLrpknvtDSLSTYINANYIRGYS-GKEKAFIATQGPMINTVDDFWQMVWQED
 ...||. ||.|.........      |....||||| |||.  |||.|      |. |.||||.|..||| .....|||||||. |||.|||.|||...
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

SPVIVMITKLKEKN-EKCVLYWPEKRG----IYGKVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRla
..||||.||| |.. |||  |||.. |    .|||. | ..|. ..|.||.|.| |.   .. . .|.|..||.||||..|.|...||...  |.. .  
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

sqGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
  . ||.|||||||.||||.|||  . ..||..|| ||....|..||. | ||||| |||.|...||. | 
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0046845 (Phosphotyrosine protein) phosphatases II 393-648 2.9e-88 291.2 In-house 2-274 (284) alignment 
Range on Protein: 393-648
Range on HMM: 2-274/284.0
LQSEFMEIPMNFV----DPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYS----GKEKAFIATQGPMINTVDDFWQMVWQED
|. ||.|.....|    . .    | . .||||| |||.  |||.|.. . ... |.||||.|..||.     ..|.|||||||. |||.|||.|||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SPVIVMITKLKEKN-EKCVLYWPEKrG---IYGKVEVLVISVNECDNYTIRNLVLKQ---GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLA
..||||.|.| |.. |||  |||.. |   .||.. | ..|....|.||.|.| |.    .. . .|.|..|||||||..|.|...||... .|.| . .
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

SQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEG---VVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
. | ||.|||||||.||||.|||  . ..||..||   .||.|..|..||. | ||||| |||.||..||. | 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 389-647 4.9e-86 284.0 In-house 21-285 (288) alignment 
Range on Protein: 389-647
Range on HMM: 21-285/288.0
SSHLLQSEFMEIPMNFVDP--KEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSP
. ..|. || |.. ...|.  .    | . .||||. |||.  |||.|.. .  .. |.||||.||.||  | | |||||||. |||.|||.|||.....
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvr

VIVMITKLKEKN-EKCVLYWP-EKRGIYGKVEVLVISVNECDNYTIRNLVLK------QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLas
||||.||| |.. |||  ||| ..  .||.. |  .|. ..|.||.|.| ..      ... ...|.|..||.|||| .|||...||... .| . .   
vIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..

QGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
.| ||||||||||.||||.|||  . ..||..||.||.|..|..||. | ||||| |||.||..||. |
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 390-647 2.5e-83 275.0 In-house 11-271 (273) alignment 
Range on Protein: 390-647
Range on HMM: 11-271/273.0
SHLLQSEFMEIPMNFVDP--KEIDIPRHGTKNRYKTILPNPLSRVCLrpknvTDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPV
..||. || ... ....   .    |....||||| |||.  |||.|     .|. | ||||.|..||  | | |||||||. |||.|||.|||.....|
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrv

IVMITKLKEK-NEKCVLYWPEKRG----IYGKVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQG
|||.|.| |. .|||  |||.. |    .|||. | ..|....|.||.|.| |.    ... .|.|..||.||||..|.| ..||... .|.. . |. .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

RGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
 ||||||||||.||||.|||  . ..||..|| ||.|..|..||. | ||||| |||.|...||. |
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
DSPc_SM00195 400-645 5e-81 267.3 In-house 9-259 (263) alignment 
Range on Protein: 400-645
Range on HMM: 9-259/263.0
IPMNFV--DPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYsGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE-
. ..    . .| ....  .||||| |||.  .|| | ... . . |.|||||||.|.  |.|..||||||. .||.|||.|||.|....|||.|. .| 
leestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KNEKCVLYWPEK---RGIYGKVEVLVISVNECD-NYTIRNLVLKQGS--HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASqgRGPVVVHCSA
..|||  ||||.      .||..| ...|.... ....|.| |..     |. |..|.|..||||..|||....|.|.  |....  |   ||.||||||
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|.||||.|....| ...|.||  ||  .||..||. | |||||.||| |...|. 
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 400-645 5e-81 267.3 In-house 9-259 (263) alignment 
Range on Protein: 400-645
Range on HMM: 9-259/263.0
IPMNFV--DPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYsGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE-
. ..    . .| ....  .||||| |||.  .|| | ... . . |.|||||||.|.  |.|..||||||. .||.|||.|||.|....|||.|. .| 
leestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KNEKCVLYWPEK---RGIYGKVEVLVISVNECD-NYTIRNLVLKQGS--HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASqgRGPVVVHCSA
..|||  ||||.      .||..| ...|.... ....|.| |..     |. |..|.|..||||..|||....|.|.  |....  |   ||.||||||
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsa

GIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|.||||.|....| ...|.||  ||  .||..||. | |||||.||| |...|. 
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0036941 (Phosphotyrosine protein) phosphatases II 391-648 6.4e-81 267.2 In-house 13-277 (297) alignment 
Range on Protein: 391-648
Range on HMM: 13-277/297.0
HLLQSEFMEIPMNFVDPK--EIDIPRHGTKNRYKTILPNPLSRVCLrpknvTDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVI
.||..||.|.. ......      |.. .||||| |||.. .||.|     .|. | ||||.|. ||. | | |||||||. |||.|||.|||.....||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvI

VMITKLKEKNE-KCVLYWP---EKRGIYGKVEVLVISVNE--CDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQG
||.|.| |..  ||  |||   ..   ||.. | ..||..  .|.||.|.| ..   .. . .|.|..||.||||..|.|...||...  |.. . .. .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

RGPVVVHCSAGIGRTGCFIATSIGCQQLK---EEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
 |||.||||||.||.|.|||  . .|||.   .|| || |..|..||. | |.||| |||.|...||  . 
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 390-648 2.3e-80 265.5 In-house 17-276 (317) alignment 
Range on Protein: 390-648
Range on HMM: 17-276/317.0
SHLLQSEFMEIPMNFVDPKEI-DIPRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVI
 ..|..||.... ...|. ..   | .. ||||. |||.. |||.| | .  |  |.||||.|. |.. | | |||||||. |||.|||.|||.... ||
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvi

VMITKLKEKN-EKCVLYWP-EKRGIYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLasQGRGPV
||.|.|.|.. |||  ||| ..   ||.. | ..|. |....|.|.| ..  ..| . .|.|..||.||||..|.| ..||...  |.| .   .. |||
vmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpv

VVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
.||||||.||||.|||  . ..||..|| ||. ..|..||. |.|.||| |||.|.. ||. | 
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPRB_pd Subfamily PTPRB 413-646 5.8e-80 263.5 In-house 49-283 (293) alignment 
Range on Protein: 413-646
Range on HMM: 49-283/293.0
PRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEK--R
..  .||||. |||   ||| | . . ..| | |||||||.||. . . |||||||. .||||||.|||.. | .|||.|.| ||  .||  |||..   
avnraknrytnilpydhsrvkLaalk.desgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep

GIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLK
 .||...| ... .| ....||.| .........|..| .||||||  |.....||...  |.|    .. ..|.|||||||.|||| |||     |...
vlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaie

EEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL
|| .|| ..||..||..|  .||| .|| |.|...  
eedyvdifgivaelReeRnllvqtekqYifihqcvld
0043336 (Phosphotyrosine protein) phosphatases II 392-647 3.7e-79 261.3 In-house 21-276 (278) alignment 
Range on Protein: 392-647
Range on HMM: 21-276/278.0
LLQSEFMEIPMNFVDPKEID-IPRHGTKNRYKTILPNPLSRVCLRPKNVTDSlSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVM
||. || |.. ...|...|   | ...||||| |||.. |||.| . .   . |.||||.|. ||. ..| |||||||. .||.|||.|||......|||
llllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdld.sdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivm

ITKLKEKN-EKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLasQGRGPVVVH
.|.|.|.. .||. |||..   ||.. | .......|.||.|.| ..  . . ...| ||.|..||||..|.| ..||... .| | .      |||.||
LtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVH

CSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
||||.||||.|||  . ..||. || ||....|..||. |.|.||| .||.|...||. |
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 386-647 6.5e-79 261.1 In-house 22-303 (307) alignment 
Range on Protein: 386-647
Range on HMM: 22-303/307.0
VVASSHLLQSEFMEIPMNFV----DPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYI--------RGYSGkEKAFIATQGPMINTV
.  . ..|. || ...   |    . ..   | ...||||| |||.. .||.| . . ... | ||||.|.         ||    ..|||||||. .||
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetv

DDFWQMVWQEDSPVIVMITKLKE-KNEKCVLYWPEKrG---IYGKVEVLVISVNECDNYTIRNLVLK---QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQ
.|||.|.|.... ||||.|.|.| ..|||. |||.. |    ||.. | ..|....|.||.|.| ..   . . . .|.|..||.||||..|.| ..||.
edFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

LMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
..  |.. . .... |||.||||||.||||.|||  . ..||..||.   ||.|..|..||. |.|.||. |||.|...||. .
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 417-644 2.8e-78 257.9 Pfam-A 3-233 (235) alignment 
Range on Protein: 417-644
Range on HMM: 3-233/235.0
TKNRYKTILPNPLSRVCLrpkNVT----DslstYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWP---EK
.|||||.|||   .|| |   . .    |    ||||||..||. ..|.|||||||. .|..|||.|||||.. ||||.|.|.|| .|||  |||   |.
kknRykdilpydktrvkl...kgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

RGIYGKVEVLVI-SVN-ECDNYTIRNLVLKQGSHT---QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSI
   ||...| .  ... ....||.|.| ||.  .    ..||...||.||||..|.|...||.|. .||...  .. .||||||||||.||||.|.| .|
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldi

GCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
 ..||..|. || |.||..||  | ||||. |||.|...|.
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 417-644 2.8e-78 257.9 In-house 3-233 (235) alignment 
Range on Protein: 417-644
Range on HMM: 3-233/235.0
TKNRYKTILPNPLSRVCLrpkNVT----DslstYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWP---EK
.|||||.|||   .|| |   . .    |    ||||||..||. ..|.|||||||. .|..|||.|||||.. ||||.|.|.|| .|||  |||   |.
kknRykdilpydktrvkl...kgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee

RGIYGKVEVLVI-SVN-ECDNYTIRNLVLKQGSHT---QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSI
   ||...| .  ... ....||.|.| ||.  .    ..||...||.||||..|.|...||.|. .||...  .. .||||||||||.||||.|.| .|
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldi

GCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
 ..||..|. || |.||..||  | ||||. |||.|...|.
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 397-652 5.5e-78 256.7 In-house 1-268 (270) alignment 
Range on Protein: 397-652
Range on HMM: 1-268/270.0
FMEIPMNFVDPKEI-DIPRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLK
|.|.. . ...... .. |. . |||. |||.| .||.| . .  || ..||||||.||..|..|..||..||. .|. .||.|.|.| .. |||.|.|.
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleelee.dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EKN-EKCVLYWPEKRGI-----YGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQ------PLLQLMLDVEEDRLASQGRGP
||. .||  |||....      .||..||..| .  . | ...| |.. ...... |.||..||||  | ...       ||... .| . .   .  .|
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLS
..||||||.||||..||. |... |.|.. || |.|. .|| ||  .||..|||||...|. .| .|..
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 415-645 2.3e-75 248.6 In-house 46-277 (318) alignment 
Range on Protein: 415-645
Range on HMM: 46-277/318.0
HGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRG-IY
  .||||  ||.   .|| |..... .  | ||||||| ||  ..||.||.|.|. .|..|||.|||. .| ||||.|...|.  .|.  |||.|    |
nkaknryanilaydhtrvkLqmleg.eegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy

GKVEVLVISVNECDNYTIRNLVLKQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE
||. | . .  |...|..|.. ...   .....|. | ||||||. .|.|.  ||.|. .|..   ...|.||.|||||||.|||| ||| .|  ...|.
gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq.qksgagpivvhCsaGvGrtGvfiavdillerika

EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|..|| . .| |||  |  |||| .||||....| 
ealvDvfqtvkqlreqrnlmvqtedqyefiydvll
0045098 (Phosphotyrosine protein) phosphatases II 394-649 4.4e-75 247.9 In-house 12-273 (278) alignment 
Range on Protein: 394-649
Range on HMM: 12-273/278.0
QSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVClrpknvtdslsTYINANYIRGYsgKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITK
. ||  .. .. .  .   . .. ||||| |||.. |||.            ||||.||.||  . |.|||||||. .||.|||.|.|.....||||.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmlte

LKEK-NEKCVLYWPEKR-GIYGKVEVLVISVNECDNYTIRNLVLK------QGSHTQHVKHYWYTSWPDHKTPDSA--QPLLQLMLDVEEDRL-------
|.|. .|||. ||||.   .||...| ..|. ..|.||.| | .       ..  . .|.|..|..|||| .|..   ...|.|.  ..| .        
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

----ASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLkeEGVVDALSIVCQLRMDRGG-MVQTSEQYEFVHHALCLYES
    . .. |||.||||||.||||...|  . ...|  ||.||.|..|..||. |.| .||. |||.|....|... .
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 388-647 5.6e-74 244.1 In-house 20-282 (319) alignment 
Range on Protein: 388-647
Range on HMM: 20-282/319.0
ASSHLLQSEFMEI--PMNFvDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDS
....||. ||...  . |. . .. . ..  .||||. ||.   .|| | . .     |.||||..| ||  . ..|||||.|. ||..|||.|||.|.|
tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeees

PVIVMITKLKEKNE-KCVLYWPEKR-GIYGKVEVLVISVNECDNYTIRNLVLKQGSHT---QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlASQG
 ..||.|||.|| . |.  ||||.    ||.. | . . .| ..| ||.| |.. |      .|||. ||.||||. |..|. ||.|. .... |   . 
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksr.ektq

RGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
 ||.|||||||.|||| ||. ..  ...|||||.|  |.| .||. |  |||. |||.|...||  .
sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN6_pd Subfamily PTPN6 408-649 2.1e-73 242.0 In-house 47-298 (306) alignment 
Range on Protein: 408-649
Range on HMM: 47-298/306.0
KEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDslSTYINANYIR-GYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYW
|| . |.  .|||||.|||   .|| |. ..|..  |.|||||||.    |..|..||||| . .|| |||.|||||.| ||||.||  |. .|||. ||
kegakpenkeknryknilPfDhtrvilkepsvpg..sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW

PEK--RGIYGKVEVLVISVNECDNYTIRNLVL---KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQ--GRGPVVVHCSAGIGRTGCF
|..  .  |||..|  .| .. ..|..|.|..   |.......| .| ..||||| .| . . .|... ||.. .  ..    ||.|||||||||||| |
PdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtf

IATSIGCQQLKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYES
| . |  ......|.   .|  ..| ..|  | |.||| .|| ||..|.  |  
iviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 412-646 2.7e-73 241.5 In-house 44-277 (288) alignment 
Range on Protein: 412-646
Range on HMM: 44-277/288.0
IPRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRG
 ..  .||||. |||    || |.  . . . . ||||.|| |.  |.|..||||||. .||.|||..|.....  |||.|.| |. ..||  |||..  
lavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

--IYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASqgRGPVVVHCSAGIGRTGCFIATSIGCQQL
   ||.|.| .....| .... |.| |..  .  ....| |..||||. |.|..|||.|.  |.    |    ||..||||||.|||| |||     ...
pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidav

KEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCL
.|| ..| ...|..||. |  .||| .||||....|  
eeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 388-647 2.8e-72 238.4 In-house 19-282 (305) alignment 
Range on Protein: 388-647
Range on HMM: 19-282/305.0
ASSHLLQSEFMEIPMNfVDPKEIDIPR-HGTKNRYKTILPNPLSRVCLRPKNVTDsLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSP
 |.. |. .. .....  .. ...    . .|||.| | . . .|. |..|. .|  | ||||.|. ||..| |..|..|||. |||.|||.....|   
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvs

VIVMITKLKEK-NEKCVLYWPEKRGI---YGKVEVLVISVNECDNYTIRNLVLKQ---GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQ
.|||.|||.|  ..||  ||||. .    .|...| . | ..  .|..|.| . .    .... | .|  |.||||  |..|  ||.|. .|..|.  ..
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

GrGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
|  |..||||||.|||| ||| .|  ..||.|.|||   .. |||  | .|||| .|| |.| || ..
g.vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
0042113 (Phosphotyrosine protein) phosphatases II 413-647 2.8e-72 238.3 In-house 7-242 (245) alignment 
Range on Protein: 413-647
Range on HMM: 7-242/245.0
PRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPE-KRG
| ...||||. |||.. .||.| | .  |  |.||||.|. ||  ..| |||||||. .||.|||.|.|.... .|||.|.. |.. .||  |||.    
penkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

IYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLAsQGRGPVVVHCSAGIGRTGCFIATSIGCQQL
 ||.. | ..|.. .|.||.|.| ..  . . ...| ||.|..||||..||. . ||...  |.. . .  . |||.||||||.||||.|||  . ..||
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleql

KEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
..|. |.. ..| .||. |.|.||| .||.|...||. .
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 416-645 7.8e-72 237.0 In-house 57-287 (298) alignment 
Range on Protein: 416-645
Range on HMM: 57-287/298.0
GTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKEkAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPE-KRGIYG
  ||||  |..   ||| |. .. .|  |.|||| .. .|.|.. ||||||.|. .|| |||.||..||. .|||.|.|.|... |.  |||. .   ||
kkkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg

KVEVLVISVNECDNYTIRNLVLKQG--SHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE
...| . | .|  ....|.| ...   .....|..  .|||||. .|  |. .|.|. .|.       |  ||.|.||||.||.| ||| .   ...|.|
eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkke

GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
 ||| . .|  ||..| |.||| ||| |...|  
qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
0040439 (Phosphotyrosine protein) phosphatases II 412-647 1.1e-71 236.7 In-house 8-245 (249) alignment 
Range on Protein: 412-647
Range on HMM: 8-245/249.0
IPRHGTKNRYKTILPNPLSRVCLRPKNVtDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWP-EKR
 | .. ||||. |||.. |||.| . .    || ||||.|| ||  | . |||||||. .||.|||.|.|.... ||||.|.|.|. .|||  ||| .. 
lpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

GIYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQ
  ||.. | ..||...|.||.|.| |.  . . . .|.|..||.||||..|.| ..||...  |.. . .    |||.||||||.||||.|||  . ..|
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

LKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
|..|. ||....|..||. |.|.||. |||.|.. ||. .
lekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 416-645 1.9e-71 235.2 In-house 10-239 (250) alignment 
Range on Protein: 416-645
Range on HMM: 10-239/250.0
GTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWP-EKRGIYGK
  ||||  |..   ||| | ... .|  | |||| .. ||... |||||||||. .|. |||.||..|.| .|||.|.|||.....  ||| ||  .||.
keknryadiialdssrvvLekek.gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGd

VEVLVISVNECDNYTIRNLVLKQGSHTQH--VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQ-GRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE
| | . | .|  .||.|.|.| . .....  |... ...|||   |. |.  |.|. .|.  .   | | .||.|.||||.||.|.||| .   ..||.|
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq..qqagnaPvivqCsaGvgrsGafiaidavlerlkke

GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
 |||   .. .|| || ..|.. ||| ||.... 
kvvdvfkvikvlrkdrphavesleqyvfvyeiil
0037934 (Phosphotyrosine protein) phosphatases II 412-647 8.9e-70 230.3 In-house 7-241 (243) alignment 
Range on Protein: 412-647
Range on HMM: 7-241/243.0
IPRHGTKNRYKTILPNPLSRVCLrpknvtDSlSTYINANYIRGYsgkEKaFIATQGPMINTVDD----FWQMVWQEDSPVIVMITKLKEK-NEKCVLYWP
.| . .||||..|||.. |||.|      .. | |||||.|...   .. .||||||. .||.|    ||.|.|.... ||||.|.|.|.  |||. |||
lpenlsknrysdilpydhsrvkl......eg.sdyinanliyvt...pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

EKRgIYGKVEVLVISVNECDNYTIRNLVLKQ---GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLA------SQGRGPVVVHCSAGIGRTGC
..   ||...| ..|....|.||.|.|.|.    . .|..| ||.|..||||..||| ..||... .| |   .        . |||.||||||.||||.
gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FIATSIGCQQLkeeGvVDALSIVCQLRMDRGG-MVQTSEQYEFVHHALCLY
.||  . ...|   | ||....|..||. |.| .||| .||.|...||. .
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 417-644 8.3e-69 226.8 In-house 45-273 (314) alignment 
Range on Protein: 417-644
Range on HMM: 45-273/314.0
TKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGIYGKV
.|||.. ||.   ||| | . .  |. | ||||..| .|  . .|||.||||. .|| |||..|..|..  |||.|.|.|.   ||. ||||.  .||..
eknrsgdilaydrsrvflitid.gdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

EVLVISVNECDNYTIRNLVLKQ----GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE
.| .....   .. .| . ...     . .. |... ...||||..| ||. ||.|.  |.. .   .. |..||||||| ||||.||| .| .. ...|
kvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq..eeeaGrivvhCsaGaGrtGtfiaidivldmiere

GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
||||   .| .||  .  ||.| ||| |.. ..
gvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Ptp69D_pd Subfamily Ptp69D 414-649 2.9e-68 225.3 In-house 47-287 (307) alignment 
Range on Protein: 414-649
Range on HMM: 47-287/307.0
RHGTKNRYKTILPNPLSRVCLRPKNVTDSlSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWP-EKRGI
    ||||. | .    || |.. | ... |.||||..|.||  | | ||| |.|. .|..|||.|... .. .|||...|.|||. ||  ||| |.   
enalknRyedikafDktRvkLkkingked.sdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevq

YGKVEVLVISVNECDNYTIRNLVLKQGS-------HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdrLASQGRGPVVVHCSAGIGRTGCFIATSIG
||.. | ..| .....|.||.| . .         ....|  | ||.|.| | |..|. ||.|.  |.|  | .. |.|.||||||| ||.| |.| .. 
ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre..lyklnrsPivvhCsaGvgrsgifvaldsl

CQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYES
 ||||.|  ||   .|..|| .|  .||  |||.|...||  |.|
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRG_pd Subfamily PTPRG 413-645 6.1e-68 224.4 In-house 45-284 (563) alignment 
Range on Protein: 413-645
Range on HMM: 45-284/563.0
PRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRG-
|    ||||  |..   ||| |.|   ...   ||||||| ||  |.|||||||||. .|.||||.|.|.. . .|||||.|.|. ..||  |||.    
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdese

IYGKVEVLVISVNECDNYTIRNLVLKQ-----GSH---TQHVKHYWYTSWPDHKTPDSAQPLLQLMldVEEDRLASQGRGPVVVHCSAGIGRTGCFIATS
 ||...|  |. .    ||.|.||.|.     ...    ..|..| ||.|||| .|... | |. .  . ...   .  ||.|||||||.|||| .|. .
tygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv..kkssaankaeaGPivvHcsaGvgrtGtyivld

IGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
   .|...| .|. . .. ..|. |  .||| ||| |.| || 
tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_PTPRA_pd Subfamily PTPRA 414-647 2.7e-66 218.7 In-house 57-294 (330) alignment 
Range on Protein: 414-647
Range on HMM: 57-294/330.0
RHGTKNRYKTILPNPLSRVCLRPKNVTDsLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRG-I
    |||.  |||.  ||| | .|. ..  | |||| .| ||  |.| |||.|||  .||.|||.|.|. .|  |||.|.|||. .|||  |||..    
enkeknrvvnilPydfsrvilsvkeGve.esdyinasfidGykekdk.fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt

YGKVEVLVISVNECDNYTIRNLVLKQ-GS-----HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGC
||.. | |  .... .||.|.....| .      ... |. . .|||||   |  .. .|.|.  |.. .   |  ||.|||||||.|||| ||. .   
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln..qqsagpivvhcsaGvGrtGtfivldavl

QQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
...| |..||   .| .||. |  |||| |||||....|  |
ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN12_pd Subfamily PTPN12 413-645 3.4e-66 218.1 In-house 38-274 (290) alignment 
Range on Protein: 413-645
Range on HMM: 38-274/290.0
PRHGTKNRYKTILPNPLSRVCLRPKNVTDsLSTYINANYIRGYSGkEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEK--R
... .||||| |||   ||| |. .. ..  | |||||.|.| .| ....||.|||. .|.||||.|.|. .  ..||. .. | .  ||  ||||.  .
eenvkknrykDilPydksrvelskieeee.gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

GI-YGKVEVLVISVNECD-NYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLasQGRGPVVVHCSAGIGRTGCFIATSIGCQQ
 . .|..|| ... . .| ...|| | ... .....|. . ||.|||| .| ||..||.|. .|.| .   .   |.|||||||.||||  ||  .  ..
elefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrel

LKEEGV---VDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
||.| .   .|  ..| .|| .|  .||| ||||.|..|. 
lkaekipeeldvfdlvlelrkqraalvqtkeqyelvykava
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 389-645 7.1e-66 217.3 In-house 24-281 (297) alignment 
Range on Protein: 389-645
Range on HMM: 24-281/297.0
SSHLLQSEFMEIPMNFVDPKEIDIPR-HGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGkekAFIATQGPMINTVDDFWQMVWQEDSPV
.... . ||  .|   . |.     .    |.||| |||   ||| |.  | .|  | |.|| ...|.      .|.|| || .||.|||.||..|.  .
htdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn.ddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvst

IVMITKLKEKNEKCVLYWPEKRG-IYGKVEVLVISVNECDNYTIRNLVLKQGS--HTQHVKHYWYTSWPDHKTPD--SAQPLLQLMLDVEEDrLASQGRG
|||.....|...||  ||..|    .|.| |.. ||.|.  .  |.|....|.   .. || | ...|||.. .   ||. ||.|. .|..|   ..  |
ivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkd.fsqnaeg

PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|..|||.||.|||| ...      . |.|  || . .| .|| .|  .||| |||.||. |. 
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPN9_pd Subfamily PTPN9 413-649 1.6e-63 209.6 In-house 40-291 (297) alignment 
Range on Protein: 413-649
Range on HMM: 40-291/297.0
PRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWP---EK
.   .||||. .|    .|| |  ..  |. | |||||.. ||  ..|||||||||. .||.|||.|||...  ||||.|.. |.   ||  |||   |.
ranleknrytdvlcydetrvvlakvd.edeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

RGIYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDR----------LASQG-RGPVVVHCSAGIGRT
.  .|...| ...|.| ..|..| |..|  . .....| |. ..||||. .|.||. ||...  | | .           . .    |.|||||||||||
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrt

GCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYES
| ||.  |  ..|.|.|.||    | .||  |  ..|| ||||| . |.  |  
Gtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 417-651 3.6e-63 208.2 In-house 48-286 (290) alignment 
Range on Protein: 417-651
Range on HMM: 48-286/290.0
TKNRYKTILPNPLSRVCLRPKNVT-DSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK-RGIYG
..||...|...   |. |||..   |    |||| || ||. ..|..||||||. ||. |||...|||....|||.|. .|... ||  |||..    ||
llnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkayg

KVEVLVISVNECDNYTIRNLVLKQGSH---TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE
.... ... .....|..|.| .|. .    .|.|..|  |.|...      |  |...  ... .   .|....|||||...||.. |.|. .. .. | 
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq.rkrgntsivvHCSdtvgrsavfcaaattinkckt

EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRL
|||.| .... ..|. . |.||| .||..... .  | ...
egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 416-644 5.2e-62 204.6 In-house 50-275 (315) alignment 
Range on Protein: 416-644
Range on HMM: 50-275/315.0
GTKNRYKTILPNPLSRVCLrPKNVTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGK
  ||||  |..   ||| | |   .|. | |.|||.| ||. |.. .||.||| ...|.|||..|..||   |||.|.| |... |.  |||.|. ||||
kqknryiniiaydksrvql.pllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGk

VEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQgrGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVV
. |  .| .  ..||.| |    |.. ..|  . |||||| . | .. ||..|.  |   . .|   |..|||||||.|||| ||. .   .|.. | ..
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenai

DALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|   .. ..|  | .|||. |||.|.. ||
dvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 416-645 2e-61 202.6 In-house 42-273 (281) alignment 
Range on Protein: 416-645
Range on HMM: 42-273/281.0
GTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKR--GIY
 .||||. |     .|| . |.. ... . |||||.. ||.|. |..||||||. .....||||||...  .|||.|.  |..  ||  |||...   .|
vlknrYsnivaYDatrvkvtpne.enkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselky

GKVEVLVISVNECDNYTIRNLVL-KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLAsQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE
|.| |  .. .|  .|  |.. | .....|..|..  ||.||||  |.... ||.   .|.. .   .   |.|.|||||.||||..||    ......|
gdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek.ktkaplvihCsaGvGrtGtyialDrlvkaveae

-GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
   .|   .| .|| .|  ||||  |||||..|. 
leeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 390-645 2.5e-61 202.7 In-house 33-288 (319) alignment 
Range on Protein: 390-645
Range on HMM: 33-288/319.0
SHLLQSEF---MEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSP
   |. ||    ....|  | .  ....   |||.  ||.   ..| |.. .     | |||| .. ||  |.| .||.|||. ||..|||.|.|. .. 
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerli.GeefsdyinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncs

VIVMITklkekNEKCVLYWPEKRGI-YGKVEVLVISVNECDNYTIRNLVLKQGSH---TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRG
 ||..|     ..||  ||| |  | ... .| | ||.|...|..|.. | . ..    .... . .  |||.  ||.. .|..|.  |.  .   ..| 
tivllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
..|||||||.|||| .|.  .  ...|||  ||   .| .|| .|  .||   || |.. || 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 412-647 1.7e-60 199.8 In-house 45-287 (325) alignment 
Range on Protein: 412-647
Range on HMM: 45-287/325.0
IPRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMV--WQedSPVIVMITKLKEKNEKCVLYWPEK-
 |    |||.| ...   |||.|  |.  |. | ||||.|.| . .| . |.|.| |. .|..|.|..|  |.  ..|.|.. .|......|  |||.. 
kpenkaknrfknvvaldksrvvletkk.ddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvlneldlgkdrcavywpkem

--RGIYGKVEVLVISVNECDNYTIRNLVLKQGSH--TQHVKHYWYTSWP---DHKTPDSAQPLLQLMLDVEEDRLA-SQGRGPVVVHCSAGIGRTGCFIA
     .| .|| .....|  .|  | | .|| ..  |. || . . ||.    .| | .  ..|||.  |.|   | ... .|..||||||.|||| ||.
gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
     ... ||  || .  | .|| ||  ||.| .|| ....||  .
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 401-645 3.2e-60 199.0 In-house 11-252 (284) alignment 
Range on Protein: 401-645
Range on HMM: 11-252/284.0
PMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITklkekNEK
..|  | .  ....   |||.  ||.   ..| |..       | |||| .| ||  |.| .||||||. ||..|||.|.|. ..  ||..|     ..|
gvngtdqtfanldqnkdknrighilafdknvvklerli.GeefsdyinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt.....kdk

CVLYWPEKRGI-YGKVEVLVISVNECDNYTIRNLVLKQGSHT---QHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTG
|  ||| |  | ... .| | ||.|...|..|.. | . ..    .... . .  |||.  ||.. .|..|.  |.  .   ..| ..|||||||.||||
csqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

CFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
 .|.  .  ...|||  ||   .| .|| .|  .||   || |.. || 
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 392-644 5.5e-60 197.9 In-house 19-272 (515) alignment 
Range on Protein: 392-644
Range on HMM: 19-272/515.0
LLQSEFMEIPMNFVDPKEIDIPR-HGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVM
|.  || ..|   . |. .       .||||| |||   .|| |   |  .  | |.|| ||...   .||.||.|||   .|||||..|.||.   |.|
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin.dnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiam

ITKLKEKNE-KCVLYWPEKRG---IYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVV
.||||| .  ||  |||.| |    .|...| ..|.. | . ..|.| . .|.... |  . .| |||. .|  .. ||.|. .|  |.  .|   |...
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadh..gqythplii

HCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|||||.|||| .|.      . |.  .|| . .| ..| .|  .||| ||| |.. |.
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 417-647 7e-60 197.4 In-house 49-277 (287) alignment 
Range on Protein: 417-647
Range on HMM: 49-277/287.0
TKNRYKTILPNPLSRVCLRpknvtDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKR-GIYGK
 |||.. ||.    || |.     .    |||| .| ||. ..||||....||.||. .||......  ..|||....||. .|.|  ||||..  ..|.
dknRltqilvpdnyrvllk.....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

VEVLVISVNECDNYTIRNLVLKQGS---HTQHVKHYWYTSWPDHK-TPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE
 .. ... .  ..|..|.| .|. .   ..|.|| | .|.|...   .. .  ||..   . ..|   .|....|||||...||.. |.|  .. .. |.
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr..krgntsivvhCsdtvGrsamfcaaattinkckt

EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
|||.| .... . |. . |.||| |||.|. ...  |
eGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 393-644 7.5e-60 197.4 In-house 21-273 (315) alignment 
Range on Protein: 393-644
Range on HMM: 21-273/315.0
LQSEFMEIPMNFVDPKEID-IPRHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMI
.  || ..|   . .. .   .   .||||| |||   .|| |   .  .  | |||| ||...  ..||.||.|||   .|||||.||.||.   |||.
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid.dsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmv

TKLKEKNE-KCVLYWPEKR---GIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDrlASQGRGPVVVH
||..| .  ||  |||...     .|...| ..|.. . . ..|.||.... ... |  . .| |||. ..  .  ||.|. .|  |    .   ...||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvh

CSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
||||.|||| .|.     .|.|.. .|| . .| .|| .|  .||| |.| |.. |.
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_PTPN13_pd Subfamily PTPN13 415-644 1e-59 197.1 In-house 37-265 (273) alignment 
Range on Protein: 415-644
Range on HMM: 37-265/273.0
HGTKNRYKTILPNPLSRVCLRPKNVtdslstYINANYIRGYSGKEK-AFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRG--
. .||||. .||   .|| |  .        ||||..|.   ||..  .||.|||. .||.|||||||. .. ||.|.|. |||.. ||  ||||...  
nkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

--IYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVeedRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQ
  .....|| .. |.. |....|.| .|  . .....| |  ...||||..| ||..|||..  |   |   . .||.||||||||||.| .|.  .  .
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaev...rrlqtdagPivvhcsaGiGrsGtlitidvvlg

QLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
 .. .  .|   || .||  | |.|||..|| ||..|.
lierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN3_pd Subfamily PTPN3 412-645 7.4e-58 190.7 In-house 38-272 (280) alignment 
Range on Protein: 412-645
Range on HMM: 38-272/280.0
IPRHGTKNRYKTILPNPLSRVCLRPKNVtDslstYINANYIRGYSG---KEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPE
 |.  .||||. |||    || |.  .. |    ||||||.   .      . .||||||. .|. |||||||...| .|||.| | |.   ||  ||||
kpenlsknryrdilpydatrvklkeset.d....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

KRG--IYGKVEVLVISVNECDNYTIRNLVLKQGS--HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQgrGPVVVHCSAGIGRTGCFIATSI
.     ||. .| . . .|  .| .|.||||. .  . ... .  |..||||. ||... .|...  |.. | ...   |||||||||||||| .|.  .
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke..ePvvvhCsaGigrtGvlillet

GCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
  . . ..  |  | || ..|  |. .|||..||.|| .|..
alalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN23_pd Subfamily PTPN23 415-645 7.6e-56 184.0 In-house 43-277 (288) alignment 
Range on Protein: 415-645
Range on HMM: 43-277/288.0
HGTKNRYKTILPNPLSRVCLRpknvtDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEK-CVLYWPEKRG---
. .|||.. |||   .||.||     .|   |||| .... |     |||||.|. .|. |||.||... |.||||... .|.... .  ||||..|   
yseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

IYGKVEVLVISVNECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEE--DRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQ
 .|...| . ||.| ...  |.| |.  . .....|.|  .||||..  |.| . |||..  ||.  .    . . |.|||||||.|||| |       .
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QL-KEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
.| |..|..| . .| .|| .|  |||..||..|. .|  
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 417-644 2.3e-53 175.9 In-house 5-235 (237) alignment 
Range on Protein: 417-644
Range on HMM: 5-235/237.0
TKNRYKTILPNPLSRVCLRPKNVTdslSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPE--KRGIYG
 ||||  |     ||| |.    .   | ||||.|..|. |  | .||.|||. .. ||||||||||   ||||.| | |.|| ||  |||.  .   ||
iknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

KVEVLVISVNECDNYTIRNLVLKQGSHTQHV---KHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE
.. | .   .|  .||.| |.| .  . ..|   . | .|||||.  |. .  ||..  .. .     .  || ..|||||.|||| |.      .| ||
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
. |||    |  .  ||  ..|| .|| |.|...
kkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 417-644 2.8e-53 175.5 In-house 9-236 (239) alignment 
Range on Protein: 417-644
Range on HMM: 9-236/239.0
TKNRYKTILPNPLSRVCLRpKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRGIYGKV
.||||  |.    ||| |  |   |  | ||||.|.| | |  ||.||||| .  .  |||.|.|||   ||||.| | |  ..||  |||.    | ..
aknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

EVLVISVNECDNYTIRNLVLKQGSHTQ--HVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLAsqGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV
 | .   .   .| || .|. |  .|.  .| .| .| |||.  |. |  .| |   . .| |   |  | |.|||||.||||.|.      .| |..  
rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..garpwvihcsagvgrtgaflvidamlrqakkqkt

VDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|| .  |  .| ||  |||||||| |.| |.
vdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 417-644 3e-53 175.4 In-house 10-237 (239) alignment 
Range on Protein: 417-644
Range on HMM: 10-237/239.0
TKNRYKTILPNPLSRVCLRpKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRGIYGKV
.||||  |.    ||| |  |   |  | ||||.|.| | |  ||.||||| .  .  |||.|.|||   ||||.| | |  ..||  |||.    | ..
aknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

EVLVISVNECDNYTIRNLVLKQGSHTQ--HVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLAsqGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV
 | .   .   .| || .|. |  .|.  .| .| .| |||.  |. |  .| |   . .| |   |  | |.|||||.||||.|.      .| |..  
rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..garpwvihcsagvgrtgaflvidamlrqakkqkt

VDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|| .  |  .| ||  |||||||| |.| |.
vdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN1_pd Subfamily PTPN1 411-644 3e-52 172.1 In-house 28-267 (290) alignment 
Range on Protein: 411-644
Range on HMM: 28-267/290.0
DIPRHGTKNRYKTILPNPLSRVCLRPKNVtdslsTYINANYIRgYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKR
. |.  ..|||. . |   ||. |. ...      ||||. .      .. .| ||||. |||| ||||||...|  .||. |. ||.  ||. |||.. 
klpenrnlnryrdvspydhsrikleradn.....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

G----IYG--KVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIAT
     ..   |..| .|| .. ..||.| | |..    .|... |. ||.|||   |.| . .|... .| |    |.  ||.|.||||||||.| |.  
eekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

SIGCQQLK---EEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
     ...   .   ||    ...||  | |..|| .| .| . |.
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 406-647 9.6e-52 170.5 In-house 30-292 (301) alignment 
Range on Protein: 406-647
Range on HMM: 30-292/301.0
DPKEIDIPRH-GTKNRYKTILPNPLSRVCLRPKNVTD-SLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCV
.. .. .  .  . ||.| | . .  |. |.||.  | .  .||||.|| ||| | |.|||.|||| .|. |||...|||    |||.|.|||. ..|| 
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskce

LYWPEKRG---IYGKVEVLVISVNECDNYTIRNLV--LKQGSH---------------TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdRLASQGRG
 |||. .     .|...|.... .   ...||.|   ...||                ...|  .  |.||..      .  || . ||   |  . | |
qywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvih.rqqkiggg

PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
|||||||....|.| ... |||  | | |||||   ..  .|  . |.|.| ||| ... ..  |
pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 416-647 1.8e-51 169.7 In-house 39-276 (287) alignment 
Range on Protein: 416-647
Range on HMM: 39-276/287.0
GTKNRYKTILPNPLSRVCLRPKnvTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMI-TKLKEKNEKCVLYWPEKRG--IY
  ||||  .||   .|| |  .  ..  | ||||||. .|  ...||||.|||.  || |||..|... | .....  ...|   ||  ||||..     
vkknryadvlPiddtrvllsae..gelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GKVEV--LVISVNECDnYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDV----EEDRLAsQGRGPVVVHCSAGIGRTGCFIATSIG
|   |  |  .. | . |..| | | .  . ... || . . ||||.  . .|  |....|||    |  | | .. ||.|||...||||.| ..|| . 
GGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielarda.sevGPlvvhddvGiGrsGillatlvl

CQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
 ..|.. | ||.  .| .||. | ..||.  |. ..  ||  |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 414-644 9.8e-51 167.3 In-house 32-262 (283) alignment 
Range on Protein: 414-644
Range on HMM: 32-262/283.0
RHGTKNRYKTILPNPLSRVCLRPKNVtdslsTYINANYIR--GYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRG
.. .|||.. |.|    || |....      .|||| .|       ..| .|..|.|. .|| |||.||..|.   |||.|||.|  ..||  |||..  
enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

I-YGKVEVLVISVNECDNYTIRNLVLKQG---SHTQHVKHYWYTSWpdhkTPDSAQPLLQLM--LDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIG
. ||.  | .      . ..|..|.|..      |  . || .  |    .  . |. .  .  ..        . .||.|||||.|||||. ||| |  
edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

CQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
 .... | |||  ..|  .| .| ..||| .|| .||.. 
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPRN_pd Subfamily PTPRN 414-644 1.5e-48 160.0 In-house 55-288 (297) alignment 
Range on Protein: 414-644
Range on HMM: 55-288/297.0
RHGTKNRYKTILPNPLSRVCLRPKNvTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE-KNEKCVLYWPEK-RGI
.  .|||.|..||   ||| |. .. ... | ||||  |     .. |.||||||. .|| |||||||.. . |||..|.|.|   ..|  |||..   .
knvkknrskavlpydhsrvklkeea.saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev

YGKVEVLVISVN-ECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdrlASQGR-GPVVVHCSAGIGRTGCFIATSIGCQQ
|.  || ..|    ||.| .| . ||  | |.|. |  . . |||.. .| ||..||..   |.    . .||  |.|||||.| ||||..|.  . ...
yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk...syrGrscpivvhcsdGaGrtGvyilidlvlnr

LKE-EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|.     .|  . .  || .| |.|.| .|.||.  |.
llkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0051429 (Phosphotyrosine protein) phosphatases II 443-647 3.6e-48 159.8 In-house 3-224 (272) alignment 
Range on Protein: 443-647
Range on HMM: 3-224/272.0
LSTYINANYIRGYsGK---EKAFIATQGPMINTVDDFWQMvWQEDSPVIVMITKLKEKN-EKCVLYWP-------------EKRGIYGKVEVLVISVNEC
||.||||... || |.   ........||. .|..|||.. ....  .||..... |.. .|| .|||             . .  ||.. | ..|.  .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

DNYTIRNLVLK---QGSHTQHVKHYWYTSWPDHKTP-DSAQPLLQLMLDveedrlasqgRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVD------
..|..|.|.|.   . . . .| |..||.|||| .| ..   ||.|.||           |||.||||||..|||...|  .  ... .| .||      
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--ALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
  .. .| .||  | |.||| |||.|...||  .
lyleeaveelraqrpgavqteeqylflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 417-647 1.1e-47 157.4 In-house 3-170 (182) alignment 
Range on Protein: 417-647
Range on HMM: 3-170/182.0
TKNRYKTILPNPLSRvclrpknvtdsLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITklkeknekCVLYWPEKRgiygkve
.||||. |||.. ||            ..|||||...|.    . |||||||...|| ||..|.....  .||..|        ..|||||.        
dknrysdilpydhsr...........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

vlvisvnecdnytirnlvlkqgshTQHVKHYWYTSWPDHKTPDsAQPLLQLMLDVEEdrlasqGRGPVVVHCSAGIGRTGCFIATSIGCQQlkeeGvVDA
                        .... .|.|..|||| .||  . ||... .|.|        |||.||||||.||||...|  . ...    | |..
........................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

LSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
 ..|...|. | |||.| .|| |.. ||...
eeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN14_pd Subfamily PTPN14 411-647 1.9e-47 156.7 In-house 45-295 (300) alignment 
Range on Protein: 411-647
Range on HMM: 45-295/300.0
DIPRHGTKNRYKTILPNPLSRVCLRPKNVTdsLSTYINANYIRG-YSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEK
  |    |||.| .||   .|| | | . .   . ||||  |.   .|||. .|..|||. .|| |||||||...  .|||.|. .|. .||.. |.|..
klpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkl

-----RGIYGKVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGR-------GPVVVHCSAGIGR
     .  .|| .|    ... | .. . | ||    .. . | |  || ||||. |.  .. |. . .|.  | ...          ||.||||||.||
eskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGr

TGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
||  | . .  . |. . ..|  ... .||  |  .|||  ||.||...|  |
tGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 416-644 1e-46 154.3 In-house 49-275 (439) alignment 
Range on Protein: 416-644
Range on HMM: 49-275/439.0
GTKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEkcvlYWPEKRGI-YGK
.|||||| . .   .|| |.        | |||||||.||  ..| .||||||  .|.||||..|... .  |||.|.| |       ||| .  . || 
qtknrykdvgafdhtrvtlqeipgv.phshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcygd

VEVLVISVNECDNYTIRNLVL-K---QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE
. | |    |  ||.|| . . .   .. . . | .. |..|||.. |  |  .|...  ..     ..  ||||||||||.||||  ||  |  .||| 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan.dkeeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|  ||   ||  || .|  |||.  || |.. |.
enkvdikgivkvlrkqrkqmvqalcqyvfiynav
0049772 (Phosphotyrosine protein) phosphatases II 410-649 7.1e-45 149.4 In-house 41-281 (314) alignment 
Range on Protein: 410-649
Range on HMM: 41-281/314.0
IDIPRHGTKNRYKTILPNPlSRVCLRPKNVTDslSTYINANYIRGYsgkeKAFIATQGPMINTVDDF----------WQMV--WQEDSPVIVM-------
 |.... .||||. ||| . .||.|   .| .  | ||||.|..|.    ..|||||||. .||.||          |.||  .. .. .|||       
adlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------ITKLKEK-NEKCVLYWPEKRgiygkvevlvisvnecDNYTIRNLVlkqgshTQHVKHYWYTSWPDHKTPdSAQPLLQLMLDVEEDr
              ...| .. || .. .... .                . .. ..|.      .... .|... .||. .| . . .....  .||  
delsrLdaAlgKtpllildgngneptaadlellk................eelydpelf......erlgikylripvpDgsap.lledfdeflefieea.

lasQGRGPVVVHCSAGIGRTGCFIATSIGCQQLkeeGVvDALSIVCQLRMDRG-----GMVQTSEQYEFVHHALCLYES
   .  |||.|||.||.||||.|... . . .|   || ..  .. ..|. |      |.... |||||...||. | .
...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
0036282 (Phosphotyrosine protein) phosphatases II 444-641 7.9e-45 148.0 In-house 2-163 (174) alignment 
Range on Protein: 444-641
Range on HMM: 2-163/174.0
STYINANYIRGYSGKEkAFIATQGPMIntvddFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEkrgiygkvevlvisvnecdnytirnlvlKQGSHTQ
|.||||... ..   .  .||.|||.      ||.|...... ..|| ...||.. .||  ||||                            .. . ..
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredler

HVKHYWYTSWPDHKTPDSAQpLLQLMLDVEEDRLAsQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKeEGVVDALSIVCQLRMDRGGMVQTSEQYEFVH
.. .|.|. |||| .||... ||...  ||| ..   . |||.||||||.||||...|  . ...|. |..||||..| .||. |.||||| .||.|..
lgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 390-644 1.2e-44 147.3 In-house 19-232 (392) alignment 
Range on Protein: 390-644
Range on HMM: 19-232/392.0
SHLLQSEFMEIPMNFVDPKEID-IPRHGTKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVI
| |. .|| ..|   . |. .   .    ||||| |||   .|| |   . . . | |.|| ||...   |||.||.||| . ..||||.||.||.   |
salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddi.pdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvtti

VMITKLKEKNekcvlywpekrgiygkvevlvisvnecdnytirnlvlkQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHC
.|.||||| .                                      .| ... |  . .| |||.  |  .  ||... .|. |    |   |...||
amvtklkegd......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf..Gqythpliihc

SAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|||.||||  |.      . |.  .|| . .| ..|  |  |||| ||| |.. |.
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_CG7180_pd Subfamily CG7180 417-644 2.5e-44 146.1 In-house 44-286 (296) alignment 
Range on Protein: 417-644
Range on HMM: 44-286/296.0
TKNRYKTILPNPLSRVCLRpKNVTDSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEK-RGIYGKV
 |||. ...|    || |. |   .. | |||| |. ..  |.|..| |..|. .|||.||..|..|..  .|..||  . ....  |||.| .  ||..
eknrdvkvvPyDynRvvLe.kldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygei

EVLVISVNECDNYTIRNLVLKQG------------SHTQHVKHYWYTSWPD-HKTPDSAQPLLQLMLDVEEDRLAS---QGRGPVVVHCSAGIGRTGCFI
.| ......  | .||.. |..              .|  ||.. .| |.  .| | |.. |..|.  |.  |      . .|||||..| | .|.| ..
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

ATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
|  .  .....|. ||    | .|| .| ..|.. |.| ..   |
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
0046846 (Phosphotyrosine protein) phosphatases II 440-647 1.2e-43 144.2 In-house 8-172 (176) alignment 
Range on Protein: 440-647
Range on HMM: 8-172/176.0
TDSLSTYINANYIRGYsgkekAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRGIYGkvevlvisvnecdnytirnlvlkqg
 |  ..|||||.| |.     ..||||||. .|. ||..|.....  ..|..|...|..  ||  |||| ..                            
ldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

shtqhvkHYWYTSWPDHKTPDSaQPLLQLMLDVEEdRLASQgrGPVVVHCSAGIGRTGCFIAtsigCQQLKEEGVVDALSIVCQLRMDRG-GMVQTSEQY
       .|... |||| .||. . ||.|.  ..| .| .   |||.|||||||||||...|    .  |. |  .... .....|. |  |.||| |||
.......qylhlpwpDhgvpdl.elllellefire.alkeg..gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQy

EFVHHALCLY
.|......|.
rflyefelll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 396-644 7.2e-43 141.3 In-house 32-279 (290) alignment 
Range on Protein: 396-644
Range on HMM: 32-279/290.0
EFMEI-----PMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDslstYINANYIRGysgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVM
|..|      | .... | .|   . .||||| .  |  .|| |.     |    |. |||..|    .  || |||.. .|| |.|.|| ||.  .|||
eyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGd....yvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivm

ITKLKEK-NEKCVLYWPEKRG---IYGKVEVLVISVNECDNYTIRNL--VLKQGS-HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVeedRlasQGRGP
. .| |. . ||  |.||| |    .|.. ||    .. |. .|...  | .. | .   .||.   ||||.  . |.  ||...  .   |   .  ||
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril...r...kasGp

VVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
||||||||||||| |.|  .| | | .   .| | .|  ||  | . ||   ||  . ..|
vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 414-643 4.2e-41 135.7 In-house 30-290 (297) alignment 
Range on Protein: 414-643
Range on HMM: 30-290/297.0
RHGT--KNRYKTILPNPLSRVCLRpKNVTDslSTYINANYIRGYSG-KEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKR
| ..  ||||. ||    .|| |. . .|.  . ||||.|.      ..  .| .|||. .||||||..|...|  ||||..||.|   .||. |||.  
rnsslrknryrdilatddtrvkll.rvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

GIYGKV-----EVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTP----DSAQ------------PLLQL---------MLDVEEDRLASQ
.   |      | |    .| |.  . .| |   |....|.|  . |||||  |    |  .            |..           .| .|  | .  
qerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemp

GRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHA
   ...||||||.||.|  . . .  ..|. . . |. .|. .||  |  .||| ||.|....|
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 418-647 5.2e-41 135.4 In-house 36-258 (267) alignment 
Range on Protein: 418-647
Range on HMM: 36-258/267.0
KNRYKTILPNPLSRVCLRPKNVTdslstYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNekCVLYWPEKRGIYGKVEV
.||.   ||   .|| || |.       |||| |. ||  | .|||.||.|. ||. ||.... ... ||||..||  . |    |.|| | |   | . 
rnrlddnlpyddtrvilrtkeee.....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdn..irlfwPPkmgqakkyqd

LVIS---VNECDNYTIRNLVLKQGSHTQH-VKHYWYTSWPDHkTpdSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGV
|..     .| ..| |  | ||    . | |  |.|  |    |    .| |. .. .       .|  |.||.||.|.||.| |.      ...|.|||
ltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.t..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegv

VDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
.|    . ..|  | |.|.| |.| ..|. |. |
sdifdflrkirsqriglvdtkeryiyihellaey
0043147 (Phosphotyrosine protein) phosphatases II 442-641 2.2e-40 133.5 In-house 3-154 (172) alignment 
Range on Protein: 442-641
Range on HMM: 3-154/172.0
SLSTYINANYIRGYSGKEKaFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLkeknekcvlywpekrgiygkvevlvisvnecdnytirnlVLKQGSHT
. |.||||.|. .|    . |||||||. ||..|||.|.....  .||..|.|                                       ..     .
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.......................................lydpelle

QHVKHYWYTSWPDHKTPdSAQPLLQLMLDVEEDRlASQGRGPVVVHCSAGIGRTGCFIATSIGCqqlkeeG-VvDALSIVCQLRMDRGGMVQTSEQYEFV
... .|.|..|||| .| ... ||...  ..|   | .  |||.||||||.||||...|  . .        . ... .|...|. |.|.||. .|| |.
rlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfl

H
.
y
subfamily_ptpA1_pd Subfamily ptpA1 406-608 8.2e-38 125.2 In-house 38-256 (418) alignment 
Range on Protein: 406-608
Range on HMM: 38-256/418.0
DPKEIDIPRHGTKNRYKTILPNPLSRVCLRpKNVTDSLSTYINANYIRGYSgkEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLY
.  | |  .  .||||  |||   .|| |. |      | ||||||| |     | ||.||||. ||. |||.|||..   .|||...  |.   ||  |
etsegdkkhntsknrytnilpvnhtrvqlk.kiqdkegsdyinanyidgay..pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPEKRG-----IYGKV-EV-------LVISVNEC-DNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEED---RLAS-QGRGPVVV
|||. |     |||.  ||       ||  ...   .   ||. |     |. . .| |  ||||. || .||. ||.  . .     . | .   |..|
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGIGRTGCFIATSIGCQQL
|||||.|||| | .. |  ..|
hcsagvgrtgtfctavimmkkl
0049260 (Phosphotyrosine protein) phosphatases II 459-641 1.1e-36 121.2 In-house 8-143 (152) alignment 
Range on Protein: 459-641
Range on HMM: 8-143/152.0
EKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWpekrgiygkvevlvisvnecdnytirnlvlkqgshtqhvkHYWYTSWPDHKT
 ..|||||||. ||..|||.|... .  .|||.|.| |.. .||  |.                                        .| .. |||| .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhgv

PDSAQPLLQLMLDVEEDrlASQGRGPVVVHCSAGIGRTGCFIATSIGCqqlkeeGVVDALSIVCQLRMDRGGMVQTSEQYEFVH
||..| ||.|.| .|.   | .  |||.||||||.||||...|  . .        |... .| ..|. | |.|.. .|..|..
pdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 413-644 7.8e-36 118.2 In-house 35-265 (281) alignment 
Range on Protein: 413-644
Range on HMM: 35-265/281.0
PRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKeKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI
|    ||||  |    .||| |. |      . || |||||    | . .| ||||  .|  |||.|.|||..  |||. .. | | |||  |.| .   
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

YGKVEVLVISVNECD---NYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVeedRLASqgrGPVVVHCSAGIGRTGCFIATSIGCQQL
  ... | .| ..           | |     |. . |. .  ||| . |.|.. .|...  .   |  |    | |.|||||.||.| ..|  |  | .
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrki...rars...tppvihcsagvgrsgtlmaveialqsi

KEEG-VVDALSIVCQLRM-DRGGMVQTSEQYEFVHHAL
.    . |   || .||.  |   ||| .|| .. . |
hshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0051082 (Phosphotyrosine protein) phosphatases II 443-644 5.7e-35 115.5 In-house 2-149 (151) alignment 
Range on Protein: 443-644
Range on HMM: 2-149/151.0
LSTYINANYIRGYsgkekaFIATQGPmintVDDFWQMVWQEDSPVIVMITKLKEKNeKCVLYWPEKRgiygkvevlvisvnecdnytirnlvlkqgshtQ
||.|||..|. |.      .....||     .||........  .||......| . .|  |.||                                   
lsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg................................i

HVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdrlasQGRGPVVVHCSAGIGRTGCFIATSIGCQQlkeegvVDALSIVCQLRMDRGGMVQTSEQYEFVHH
.|.|.....|||...|.| . .|...  ...     .. |||.||||||.||||...|  . ...      |.. ... ..|. |.|.||...|. |...
evlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AL
||
al
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 416-655 1.5e-34 114.5 In-house 42-284 (307) alignment 
Range on Protein: 416-655
Range on HMM: 42-284/307.0
GTKNRYKTILPNPLSRVCLRPKNVTdslSTYINANYIrGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRG---I
  ||||. .     .|. .. . ..   | || |||. | . | | ||..|||. ||. .|| |. ||.   ..|. |. |    ||  ||| ..|   .
tdknryqdvkcqdkgrivvkfdgla...sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YGKVEvLVISVNE-------CDNY--TIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDrlasqgRGPVVVHCSAGIGRTGCFIATS
.|.     |||..        |.    . .| .. ..... ..|. .. |||. .|.     . |.  |. |      . |||||||||.||.|  .| |
fgeap.ntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd......tnpvvvhcsaGvGrsGtivais

IG-CQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAET
.   . .. .   |   .| .|| .|   .||  || ..|  |  |   |  ||
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket
PTPc_DSPc_SM00012 544-644 1.5e-34 113.7 In-house 2-103 (105) alignment 
Range on Protein: 544-644
Range on HMM: 2-103/105.0
VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE-GVVDALSIVCQLRMDRGGMVQTSEQYEFVHH
||||.||.||||..|......|.|. .|.. . .|. ..|||||||||.||||.|.| .| .|||..| . || . ||..||. | ||||| ||| |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AL
||
al
subfamily_CG42327_pd Subfamily CG42327 395-573 3.4e-33 109.6 In-house 9-192 (319) alignment 
Range on Protein: 395-573
Range on HMM: 9-192/319.0
SEFMEIPmNFVDPKEiDIP-RHGTKNRYKTILPNPLSRVCLRpKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITK
 || ..| ...   . ..|     |.|.  ..| | .|| |. .   |  . |..|.|.|||   .  .||.| .. ..  |||..||.  | ||| .|.
eefrdlP.qliarad.evPvtskdksrvinvvPlPetrvvlq.rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LKEKN-EKCVLYWPEKRG-----IYGKVEVLVISVNECDNYTIRNLVLKQ--GSHTQHVKHYWYtSWPDHKTPDSAQPLLQLMLDVEE
| |.  ..|  |.| | .      ||.. | .   .  |.| |  |.||.  .. .... ||||  |.. . | . ..|. ..|.|..
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 417-640 4.7e-33 109.2 In-house 52-273 (301) alignment 
Range on Protein: 417-640
Range on HMM: 52-273/301.0
TKNRYKTILPNPLSRVclrpKNVTDSLSTYINANYIRGYsGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGIYGKV
 |.||.|.  .| . |    . ..|     | ||.|    |. . |||||||. || .||| |. | |   |||...  ||. |||  | | | .   ..
dkhryptvPckPstav....evivdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

EVLVISVNECD-----NYTIRNLVLKQGS---HTQHVKHYWYTSWPDHKTPDSAQPLLQLMldveedRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQ
.   | ... .     . . |.| ..  .   .|. | || |..|.|. .| |   | .||       |. . . |.||||||||||. .||.| .  ..
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm......elvkksekPivvhcsaGiGrsvafigteylare

LKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFV
.. .  ..    . .|| .|   ||| .|  ..
veadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 415-647 6.4e-32 105.5 In-house 48-286 (305) alignment 
Range on Protein: 415-647
Range on HMM: 48-286/305.0
HGTKNRYKTILPNPLSRVCLRPKNVTDslstYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGI--
.  ||||| .      || |..    .    || |||.   . . | || || |. .|  ||| | .|.    | |. .|.||  .||. |.. | .   
eagknrykdvgcldnnrvklegpwphe....yihanyvstpt.npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

---------YGKVEVLV-ISVNECDNYTIR--NLVL-KQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDveedrlASQGRGPVVVHCSAGIGRTGCF
           |.|  | .. ..  . ...   ||.   |.....|.|| .  |||   | . . .|.|. .      |   .||.||||||||||||  
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek......arpskgpivvhcsagigrtgsv

IATSIGCQQLKEEGVV-DALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
.     ..|| .  .. |.  |. ..| .|   .|| .|| |||  .  |
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 416-646 9.2e-32 104.9 In-house 56-287 (305) alignment 
Range on Protein: 416-646
Range on HMM: 56-287/305.0
GTKNRYKTILPNPLSRVCLRpknvTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRGIYGK
 |||||. .  . .| | |       | | || |||.      || ||..|||. .|.|.|| || |.    |||. |  |  . ||  |||  .|   .
itknryqdvpcqdqsavkld....kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

V----EVLVISVN----ECDNYTIRNLVLKQ-GSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDrlasqgRGPVVVHCSAGIGRTGCFIATSIGC
.     |  .| .       .  |  | |   |...  |.|  .| |||   |      |.|.  .         . |.||||||||||||  .|     
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs......kvpivvhcsagigrtgtivaieyil

QQLKEEGVVDAL-SIVCQLRMDRGGMVQTSEQYEFVHHALCL
... |.  .  .  .|  || .|   .|.  || |.|  .  
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 460-641 1.3e-30 101.1 In-house 5-197 (199) alignment 
Range on Protein: 460-641
Range on HMM: 5-197/199.0
KAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKL-KEKNEKCVLYWPEK---RGIYGKVEVLVISVNECDNYTIRNLVLKQG----SHTQHVKHYWYTS
. .|||| |. .|. |||||||.  |  |||.    |.|.    .|||      | || . | . ..    .|||  |.| .       |. . || .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHKTPDSAQPLLQLMLDVEEDRLASQG-RGPVVVHCSAGIGRTGCFIATSIGCQQLKEE--GVVDALSIVCQLRMDRGGMVQTSEQYEFVH
| .. ||. |  .  ..   |  .   |    ||.|||| | | || |.|  || .  .|    ||| . .  .||  | |.. . ..|.|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 460-641 1.4e-30 101.0 In-house 4-196 (198) alignment 
Range on Protein: 460-641
Range on HMM: 4-196/198.0
KAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKL-KEKNEKCVLYWPEK---RGIYGKVEVLVISVNECDNYTIRNLVLKQG----SHTQHVKHYWYTS
. .|||| |. .|. |||||||.  |  |||.    |.|.    .|||      | || . | . ..    .|||  |.| .       |. . || .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHKTPDSAQPLLQLMLDVEEDRLASQG-RGPVVVHCSAGIGRTGCFIATSIGCQQLKEE--GVVDALSIVCQLRMDRGGMVQTSEQYEFVH
| .. ||. |  .  ..   |  .   |    ||.|||| | | || |.|  || .  .|    ||| . .  .||  | |.. . ..|.|..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0044763 (Phosphotyrosine protein) phosphatases II 442-643 2.1e-30 101.1 In-house 16-166 (178) alignment 
Range on Protein: 442-643
Range on HMM: 16-166/178.0
SLSTYINANYIRGYsgkekAFIATQGPmintvDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGiygkvevlvisvnecdnytirnlvlkqgsh
  | ||||..| ..      ......|      |.........  .||..|. .| . .||  ||||. |                              
ersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............................

tqhvKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQQlkeeGVvDALSIVCQLRMDRGgMVQTSEQYEFV
     .| .. .|||..||. . .|...  .|| .  ..  |||.||||||.||.|...|  . ...    |. .. ... ..|. |  .|.. .|....
....iqylhipipDhgvpdllehflefvefieeal..dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqL

HHA
.  
yef
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 444-646 2.3e-30 100.6 In-house 59-268 (285) alignment 
Range on Protein: 444-646
Range on HMM: 59-268/285.0
STYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE-KNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLK------
  || |...|     . ..|.||||. .|. |||.|..||    ..|.  | |   ||| ||.||| |   |.    |.. || . .|   .|.      
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

---QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdrlASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQT
     |   ...|     |||. .|. |.|...|   |..         |..||||||.|||  |.       .. |.  .. | || ..|  |   ||.
tedasseplymnhvqvpwwpdqlapedarpmielykwvkk...vnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqs

SEQYEFVHHALCL
  |. |..  |  
hmqflflyvvlme
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 443-652 2.1e-29 97.6 In-house 45-263 (290) alignment 
Range on Protein: 443-652
Range on HMM: 45-263/290.0
LSTYINANYIRGYSGkeKAFIATQGPMIN-------TVDDFWQMVWQEDSPVIVMITKLKEKNEK-----CVLYWPEKRG---IYGKVEVLVISVNECDN
 . || ||..   .|   ..|.|| |  .       |. .|| |. || .  .||. . .||...     |  | ||. |    .. ..|   |  . |.
nddyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

YTIRNLVLKQGSHTQH-VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDrlasqgRGPVVVHCSAGIGRTGCFIATSIGCQQLK-EEGVVDALSIVCQLRM
  .|.||.| . . .. |.|... .| . ..... . ||.|.  |.        . ||.|||  || |  .. |  .|.| .   .| |   ... .|| 
vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

DRGGMVQTSEQYEFVHHALCLYESRLS
 |  .... ... ||  .. |.  .  
qralaitsalelafvdagivllaievl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 416-644 7.6e-29 95.6 In-house 44-267 (288) alignment 
Range on Protein: 416-644
Range on HMM: 44-267/288.0
GTKNRYKTILPNPLSRVCLRpknvtDSLSTYINANYIRgySGKE-KAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKCVLYWPEKRGIYG
 |..||. .    ..|| |      |    ||.|| .   |.|  . .| .| |.  |.. .|.|. ..|   |||...| ||  ||   |.| | |   
ptrdryenlprcditrvkls.....ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

KVEVLVISVNECDnYTIRNLV-------LKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVeedrlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQ
..  |   | .     |  ||        |.| ... ||.  .  |.|.  |.. .. |.|.  .       . . |.|||.|||.|||| .| . |  .
rigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililiale

QLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHAL
.|. .  .   |.. .|| .|   .||  || .||  .
slrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 417-647 1.7e-27 90.8 In-house 54-289 (310) alignment 
Range on Protein: 417-647
Range on HMM: 54-289/310.0
TKNRYKTILPNPLSRVCLRPKNvtDSLSTYINANYIRGYSGkEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKL-KEKNEKCVLYWPEK--RGIYG
 ||||  ..    ||| |.  .       || |||..      ..|| .|||.  |. |||.|..|| .  |... |  .|   ||| |||       ||
hknrysdvvcldtsrvklkidk..sryedyihanyvktnyl.rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

KVEVLVISvNECDNYTIRNLVLK----------QGSHTQ--HVKHYWYTSWPDHKTPDSAqpllqlMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIAT
 . |  .| .  ... | || .           | .  .   |.   .  |||   ||           | .  ||    ||.|||||||..|... .| 
cirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagkdrlyvvval

SIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
 .  ..|..   |||  .. .|. .|   .||  || ....   ..
klkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_egg_pd Subfamily egg 417-646 4.8e-27 89.4 In-house 42-268 (307) alignment 
Range on Protein: 417-646
Range on HMM: 42-268/307.0
TKNRYKTILPNPLSRVCLRPKNVTdSLSTYINANYIRGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKnEKCVLYWPEK-----RGI
.| | | .  .  ||| |. ..    |  .| ||...|       || .| |. |||||||.||.||. . |||.|  ||  |.|  |||       . .
ekarskrvhckdssrvklelrrGq.ylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtv

YGKVEVLVISVNECD--NYTIRNLVLKQGSH-TQHVKHyWYTSWpdHKTPDSAQPLLQLmldveedRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQL
 | ...  . |..     ... .| |  | .  ....| |   .  ... |   ||  |       |.. .   ||||..  |. ......|  |   .|
pGslrienlkvdskadplfrvtklklvGgddeerfleh.wqgdv..nnssdvysplrvl.......rklrnlskpvvvqdilGvskaatlvaieiallsl

KEEGVVDAL--SIVCQLRMDRGGMVQTSEQYEFVHHALCL
    ..  |    |  ||. |   |..  .| ||.  . .
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
0048076 (Phosphotyrosine protein) phosphatases II 524-644 2.5e-25 84.3 In-house 27-139 (145) alignment 
Range on Protein: 524-644
Range on HMM: 27-139/145.0
ECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEdrLASQGrGPVVVHCSAGIGRTGCFIatsiGCQQLKEEGvVDALSIVCQL
. . .|. ||   .  ..... .|.|..|||| .||... ||...  .||  . ..| |||.||||||.||||...    ..  ....| |.. ... ..
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee..alkeg.gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelv

RMDRGGMVQTSEQYEFVHHAL
|. | |.|.. .|..|.. ..
rsqrpgavpnpgqlrflyefe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 444-643 4.5e-25 83.0 In-house 67-271 (312) alignment 
Range on Protein: 444-643
Range on HMM: 67-271/312.0
STYINANYIRGySGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLK-EKNEKCVLYWPEKRGIY--------GK-VEVLVISVNECDNYTIRN-
  || ||...    | . |..||||. ||.  |||..    |  |.... .  . .|||. |  .  |.          . .  . |  .  |. | |  
nfyihanfvki.ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl

-LVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlasqgrGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMV
 .|.|      ...|| ..|||||  ||| .  |.|.  |  |.       ||. |||||.|||| ..        |.     .   .   || ||   |
kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk......kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsv

QTSEQYEFVHHA
..  || .. ..
rvfpqyvyalrc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 415-519 3.5e-24 80.2 In-house 47-162 (350) alignment 
Range on Protein: 415-519
Range on HMM: 47-162/350.0
HGTKNRYKTILPNPLSRVCLR-----P--KNVTDSLSTYINANYIRGY---SGKEKAF--IATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-EKC
 ..||||| |||   ||| |.     .  |. . | . ||||||..        .  |  ||||.|. .|||||.... . . .||...|.. | | |||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

VLYWPEkrGIYGKVEVLV
  ||.|  | | .. | .
yrYWqe..gsydditvkl
0048179 (Phosphotyrosine protein) phosphatases II 528-642 3.8e-23 77.2 In-house 31-139 (144) alignment 
Range on Protein: 528-642
Range on HMM: 31-139/144.0
YTIRNLVLKQGS--HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLasQGrGPVVVHCSAGIGRTGCFIAtsigCQQLKEEGvVDALSIVCQLRM
.|. ||. .      .... .|....|||| .||... ||...  .|| .   .| |||.||||||.||||...|    .  .|..| ... ... ..|.
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eg.gpvlVHCsaGvgRtgtlva....aylmkklg.lsleealalvrs

DRGGMVQTSEQYEFVHH
 | |.|.. .|..|.. 
rrpgavpnpgqlrfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 468-639 6.5e-23 76.1 In-house 39-212 (255) alignment 
Range on Protein: 468-639
Range on HMM: 39-212/255.0
PminTVDDFWQMVWQEDSPVIVMITKLKE-KNEKCVLYWPEKR-GIYGKVEVLVISVNECDNYTIRNLVLKQ--G--SHTQHVKHYWYTSWPDHKTPDSA
    ||| |.|.. | .. |.||.. ..| . |||  |.| .. .     .| |.. .   .  .| |..    |   .|. |||| |. |.....|. |
l...tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

QPLLQLMldveedRLASQGrGPVVVHCSAGIGRTGCFIATSIGCQ------QLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEF
. .|...      ... .   .||||||.||||.  |. . .  |      .  | . .| ||.. .||  | . ..|  |  |
reilnil......kvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 517-644 8.2e-23 75.4 In-house 64-190 (440) alignment 
Range on Protein: 517-644
Range on HMM: 64-190/440.0
VLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRlASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDA
|..  |.   .    |    .| ... .|.| | .|||.  |  | |.|... ||.| .    | ||..|||||| ||||  ||     .. |    .| 
vmleevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidi

LSIVCQLRMDRGGMVQTSEQYEFVHHAL
.|..  .| .|  |||| ||| |||.|.
fsfinsmrnnrpqmvqtpeqyafvheav
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 464-640 7.2e-20 65.6 In-house 95-280 (302) alignment 
Range on Protein: 464-640
Range on HMM: 95-280/302.0
ATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRG---IYGKVEVLVISVNE-CDNYTI------RNLVLK----QGSHTQHVKHYW
    |  .|.. .| .. | .  ..| .....|..| ||  |. .| |    .|.  |  .||..  ...|        .. .|    .  . . |.   
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

YTSWPDHKTPDSAQPLLQLMLDVEedrlasQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFV
...|||| .|. |.. |...   |        .  |.||||||.|||| ..|   | |  ... | | ||||. .|  | | ||. .|  ..
fsawpdhGapkeaytaldilkfce......sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 465-639 1.7e-19 64.8 In-house 42-218 (263) alignment 
Range on Protein: 465-639
Range on HMM: 42-218/263.0
TqgpMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRG-IYGKVEVLVISVNECDNYTIRNLVLKQ--G--SHTQHVKHYWYTSWPDHKTP
    ...|.| |.|.. |  . |.||..  .|.  |||  |.| ..       .| | . .  ..  .. |.| .  |   .|. |||| |. |.... |
l...lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndp

DSAQPLLQLMldveedRLASQGrGPVVVHCSAGIGRTGCFIATSIGCQ------QLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEF
  |.  |...      ..| .   ..|||||.||||.  |  . .  |      .  . . .| ||.. .||  | . ..|  |  |
elareilnil......kvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_CG42327_pd Subfamily CG42327 580-650 2.8e-18 60.7 In-house 246-317 (319) alignment 
Range on Protein: 580-650
Range on HMM: 246-317/319.0
GRGPVVVHCSAGIGRTGCFIATSIGCQQLKEE-GVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESR
 .||.||||| |.||||  ||. |  ..|.|    ||   .| ..| ||.  |.| |||||... |  |   
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 460-648 1.7e-17 57.8 In-house 90-285 (302) alignment 
Range on Protein: 460-648
Range on HMM: 90-285/302.0
KAFIATQGPMINTV---DDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVI---SVNECDNYT---IRNLVLKQGSHTQHVKHYWYT
.  | .| |  ...   ..||.||.||    .|.. . .| ..    ..|.| | | . . . .    |.. .. .   .  .. .  | .  .. |  |
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvlt

SWPDHKTPDSAQPLLQLMLDVeeDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE
 |...| |..   | . . .|    . ...  ..|.    |.|| | |..  .  ..|...  . .  || ..| .|  .|.. .|| ... || || 
nWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_eak_pd Subfamily eak 424-560 2e-15 51.0 In-house 60-197 (332) alignment 
Range on Protein: 424-560
Range on HMM: 60-197/332.0
ILPNPLSRVCLRPKNVtdSLSTYINANyIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMIT-KLKEKNEKCVLYWPEKR---GIYGKVEVLV
|.|.    | | .         ||||  .  .|   . .| |  .  . |  ||||| .. || ||..  ....| ||   |.|.|      .|...|  
ivpydrylvrltssql..nrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

ISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDS
 .  . ...  |.|.|..|  | .|.|| .  | . ..|  
kefvkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 415-509 2.2e-15 50.8 In-house 48-157 (349) alignment 
Range on Protein: 415-509
Range on HMM: 48-157/349.0
HGTKNRYKTILPNPLSRVCLR-----PKNVTDS--------LSTYINANYIRGY-SGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKN-E
 ..||||| |||   ||| |.     .| .  |        |  ||||||..      || .|||| |.  |||||....  .  .... ... ||.. |
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCVLYWPEKR
||  || |  
kcdiywqels
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 413-641 9.8e-13 42.4 In-house 36-272 (303) alignment 
Range on Protein: 413-641
Range on HMM: 36-272/303.0
PRHGTKNRYKT-ILPNPL-SRVCLRPKNVTDSLSTYINANYIRGYSGKeKAfIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKR
| . .||.. . .  | .   .||   .|  | |.|| |.|.   | | || | || |.  |  |||||. ..   .....    | ..      .|...
ppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldssk.ka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

GiYGKVEVLVISVNEC------DNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQP-LLQLMLDVEE-DRLASQGRgPVVVHCSAGIGRTGCFIAT
  . | |  .| | |       | .... | . .|..   .. . | .||  . |  . | ... . ...   |  |... | |    .| ||.| |   
d.flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalf

SIGCQQLKEEGVvdALSIVCQLRMDRGG---MVQTSEQYEFVH
      |..|    .| .|  | . | |    ||   |. .|.
etahlslhseqa..sldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 585-645 2.8e-12 40.9 In-house 2-62 (69) alignment 
Range on Protein: 585-645
Range on HMM: 2-62/69.0
VVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|||||.| |||| |||  .   ..| | .|| .  |  .|  |  ||    .| |.| || 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 585-645 3.4e-12 40.5 In-house 1-61 (69) alignment 
Range on Protein: 585-645
Range on HMM: 1-61/69.0
VVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC
|||||.| |||| |||  .   ..| | .|| .  |  .|  |  ||   ..| |.| || 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 408-529 1.9e-11 38.1 In-house 89-205 (244) alignment 
Range on Protein: 408-529
Range on HMM: 89-205/244.0
KEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTdslSTYINANYIrGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEkcvlYWPE
|.   |    |||  . ||  ..|| |   ..     ||||| .. |  |.   .| || |. .|  |||.|. .    |.|..  ..|..|    |||.
kdafnpnnswknregaglpfdfnrvplskgsmg...ntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....ywpd

KRGIYGKVEVLVISVNECDNY---T
   .    | . ... . |..    
seplewyeeditvtltdrdefknik
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 539-648 5.9e-11 36.7 In-house 212-344 (350) alignment 
Range on Protein: 539-648
Range on HMM: 212-344/350.0
SHTQHVKHYWYTSWPDH---KTPDSAQPLLQLM---LDVE--EDRLASQGRGPVVVHCSAGIGRTGCFIATSIGC------QQLKEE--------GVVDA
|    | .  .  |.|      | |  . |.     .|    |  | ..   |..||||||.|||| ...           ..|..|         . | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

LS-IVCQLRMDRGGMVQTSEQYEFVHHALCLYE
.| || .||  |  |||. .|. |...||  | 
isiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 453-507 4.6e-10 33.4 In-house 230-281 (440) alignment 
Range on Protein: 453-507
Range on HMM: 230-281/440.0
RGYSgKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKneKCVLYWPE
 ||| | .|||||| |.  || |||..| .     |.|. .|..|   | .||| 
egys.kknafiatqmpldstvldfwrlvhdyristiimlnqlndk..tcsiywpv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 417-491 9.2e-10 32.6 In-house 39-116 (347) alignment 
Range on Protein: 417-491
Range on HMM: 39-116/347.0
TKNRYKTILPNPLSRVCLRPKNV----TDSLSTYINANYIRgYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMI
.||| |    .  .|| | |..     .|   ||||| .|. .   .| .| || |. .|| |||.||       .| |
sknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
PTEN_1 546-638 2.3e-09 32.3 In-house 96-183 (196) alignment 
Range on Protein: 546-638
Range on HMM: 96-183/196.0
HYWYTSWPDHKTPDSAQpLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSI-GCQQlkeEGVVDALSIVCQLRMDRGGMvqTSEQYE
 |.  ...|| .|. .. |.    ...| .|. . .. |.||| ||.||.|. .|     ...     . .||..|.. |. ..    ...| .
eylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk...ltadeAlelvrekRppgapn..spsqer
0038934 (Phosphotyrosine protein) phosphatases II 540-641 2.5e-09 32.6 In-house 75-170 (194) alignment 
Range on Protein: 540-641
Range on HMM: 75-170/194.0
HTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDrLASQGRGPVVVHCSAGIGRTGCFIATSIGCQqlkeeGVVDALSIVCQLRMDRGGMVQTSEQYEF
 ...  .|    .||. |. | . ||. .  |.|  |. .  | |.||| ||.||||...|  . .         .|   .  .|. |.|.... ...| 
fekagieylklpfpddgtvPsleillrfldlvdef.lnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdylea

VH
..
ll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 460-647 3.9e-09 29.6 In-house 116-308 (346) alignment 
Range on Protein: 460-647
Range on HMM: 116-308/346.0
KAFIATQGPMIN--TVDDFWQMVWQEDSP-VIVMITKLKEKNEKCVLYWPEKRGiYGKVEVLVISV------NECDNYTIRnlVLKQG-SHTQHVKHYWY
|  .|    | |   |.||| |..||.   | .|.   | ||    |.  |. | |     ..|         .  .|||   || .| | .  .. . .
klivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndengg.yqytgkmfinnrradvsgdpkeytie..vlpegnsdsvicqvhhh

TSWPDHKTPDSAQPLLQLMLDVEEDRLAsQGRGpVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLY
. |   . |  . |..... .   ..   |  | | |    | ||. .|| .    .|| .    . . |. ... .| | |..  ||  ..  .  |
apwkhlqqppktlpiikmihqflsekqv.qnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
subfamily_CDC14_pd Subfamily CDC14 577-641 6.5e-09 30.1 In-house 259-317 (328) alignment 
Range on Protein: 577-641
Range on HMM: 259-317/328.0
ASQGRGPVVVHCSAGIGRTGCFIAtsigCQQLKEEGVvDALSIVCQLRMDRGGMVQTSEQyEFVH
| . .| ..||| ||.||||..||    |  .|. ..  |  ..  ||. | |.| .  | .|. 
aekaeGaiavhCkaGLGrtGtLia....cylmkhyrf.taaeaiawlricrPGsvigpqq.kfle
subfamily_PTEN_pd Subfamily PTEN 522-642 3e-08 28.9 In-house 56-174 (184) alignment 
Range on Protein: 522-642
Range on HMM: 56-174/184.0
VNECDNYTIRNLVLKQGSHTQHVK-HYWYTSWPDHKTPDsaQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIgCQQLKEEGVVDALSIV
 .  |.| | ||  ..   ..... .   .   ||..|     ||. ...  |. |... .  ||||| || ||||  |.. .  ..|. |   .||.. 
kkhkdhykiynlrserkydskkfdgrvavypfdDhnppp..lelleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelf

CQLRMDRGGMVQTSEQYEFVHH
 . |.  .  |.   |  .|..
aeaRtknkkgvtiPsqrRYveY
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 444-553 3.1e-08 28.0 In-house 13-122 (130) alignment 
Range on Protein: 444-553
Range on HMM: 13-122/130.0
STYINANYIrGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEkcvlYWPEKRGIYGKVEVLVIS---VNECDNYTIRNLVLKQGSH
 |||||... | .|. . .. || |. .|  |||.|. .    |.|..  ..|..|    |||.   .    | ....    .| .|    ||  ..   
ntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede....ywpdsePlewyeediivtltdrdefknikasnleiesdln

T--QHVKHYWYTSWP
   | .  .  . ||
eshqaltmfqisnwp
subfamily_PTPDC1_pd Subfamily PTPDC1 543-642 4.5e-08 27.7 In-house 82-170 (182) alignment 
Range on Protein: 543-642
Range on HMM: 82-170/182.0
HVKHYWYtSWPDHKTPdSAQPLLQlMLDVEEDRLAsqgRGPVVVHCSAGIGRTGCFIATSIGCQQlkeeGvVDALSIVCQLRMDRGGMVQTSEQYEFVHH
.. .| . .|.|.... | . .|. .  | .  |    .| | ||| || ||||  ||. .  ..      ..|   .  .|  |   .|| || |.|..
giyvynf.gwkDygva.sleriLd.ivkvvafalq...egkvavhChaGlGrtGvliacylvyak....r.ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 523-647 4.7e-08 26.9 In-house 209-337 (347) alignment 
Range on Protein: 523-647
Range on HMM: 209-337/347.0
NECDNYTIrNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLAS-----QGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDAL
|  ..||. ..| .  | .   | |  |.|| .| ||  . .| |.     .  .|     . . |||| |  |. |.   . |||  .|. .    |  
nwmnkytv.evvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcd

SIVCQLRMDRGGMVQTSEQYEFVHHALCLY
..  ..| .| |.   |  | .   |  .|
dlfkkmrdqragvftmsifytyairaalfy
subfamily_CDKN3_pd Subfamily CDKN3 521-643 1e-07 25.8 In-house 79-191 (202) alignment 
Range on Protein: 521-643
Range on HMM: 79-191/202.0
SVNECDNYTIRNLVLKQGSHTQHVKHYwytSWPDHKTPDSAQPlLQLMldvEEDRLASQGRGPVVVHCSAGIGRTgCFIATsigCQQLKEEGVVDALSIV
.  | . | .|.|. .  .    |.||     .|  .|| |.  |...   || |.. .     .|||  |.||. .....   |  |  . ...    .
trgelskyrvrrlldlyqqaglivhhy...piadglvpdiasc.lkil...eelrinlkayrktlvhcygglgrs.slvia...clllylddtiepkdai

CQLRMDRG-GMVQTSEQYEFVHHA
 .||  .| . .||  ||..... 
dklrdlkgsraiqtvkqynylsef
subfamily_DSP23_pd Subfamily DSP23 567-643 2.2e-07 25.6 In-house 73-141 (148) alignment 
Range on Protein: 567-643
Range on HMM: 73-141/148.0
LMLDVEEdrlASQGRGPVVVHCSAGIGRTGCFIAtsigCQQLKEEGVVDAlSIVCQLRMDRGGMVQTSEQYEFVHHA
..  |||   | .    | |||  | |||| ..|    |  .||...  |   . ..|  | | |.| || . |.. 
fvrvvee...aeekneavsvhcllgrgrtgtmla....cylvkerklaaa.eaiaevrrlrpgsvetveqeklvrdy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 428-511 2.5e-06 21.2 In-house 47-127 (332) alignment 
Range on Protein: 428-511
Range on HMM: 47-127/332.0
PLSRVCLRPKNVTDSlstYINANYIRGYSgKEKAFIATQGPMINTVD-DFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGI
  ||| | |..  |    . ||... ||| |. |.| .| |. .  .  ||.|| .    .|...  . ||...   |    ||.
dhsrvelapqdgkdd...fynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgf
DSPc Dual specificity phosphatase, catalytic domain 563-627 4.2e-06 21.7 Pfam-A 57-114 (133) alignment 
Range on Protein: 563-627
Range on HMM: 57-114/133.0
PLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQQlkEEGVVDALSIVcqlRMDR
. |. . .. |.    | .. |.||| ||| |....|.  . ...  .  . .|...|   . .|
keleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktk..nlslneAyefv...kerr
DSPc Dual specificity phosphatase, catalytic domain 563-627 4.2e-06 21.7 In-house 57-114 (133) alignment 
Range on Protein: 563-627
Range on HMM: 57-114/133.0
PLLQLMLDVEEDRlaSQGRGPVVVHCSAGIGRTGCFIATSIGCQQlkEEGVVDALSIVcqlRMDR
. |. . .. |.    | .. |.||| ||| |....|.  . ...  .  . .|...|   . .|
keleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktk..nlslneAyefv...kerr
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 579-629 8.1e-06 17.5 In-house 196-246 (275) alignment 
Range on Protein: 579-629
Range on HMM: 196-246/275.0
QGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGG
. .  |.||. ||  |   |..... |.|| | |   |.    ..|  |  
dakttvlvhaiagtrrcasfvvaavmckqlleagqfsametwfemrkrrah