Gene PTPN6 in Homo sapiens

Synonym: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, PTPN6

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP086_AA protein Get Run
HsapP086_AA_226-517 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 216-522 1.8e-143 472.1 In-house 2-303 (306) alignment 
Range on Protein: 216-522
Range on HMM: 2-303/306.0
TRVNAADIENRVLELNKkqESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQgrDSNIPGSDYINANYIKNQLLGPD
|...|..||.|| ||.|  |.|...||||.||||.||..|.|.|..| ||..|||| ||||||||||||.||||.  ....||||||||||||... | |
tsllakeieqrvselek..eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsd

enaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYL
   |.|||.|||||.||.|||.|.||||||||||||.|||.|..||..|||.. ....|| .||||. |.....|.||.|.||  ....  ||...|.. 
...ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfk

SWPDHGVPSEPGGVLSFLDQINQRQESLP--HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA
||||||||..|| ||.||...|..||.|   .||||.||||||||||||.||||.|...|..||||.||||||....||.||||.||||.||||.| ||.
sWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

QFIETTKKK
..|||.|| 
kyietkkkl
0046845 (Phosphotyrosine protein) phosphatases II 243-523 3e-102 337.1 In-house 1-281 (284) alignment 
Range on Protein: 243-523
Range on HMM: 1-281/284.0
GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQE
|..|||| |... || |...  ...|||. |||||.|||.|||||.|.  |.....||||||.|..   |.   . |..|| || |. ||.|||.| |..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES
|.||||| |..||.||.|| .|||. |    ||...||.  |.    |..|||....|. ..  |...|..|.||||||||..|  .|.||..... .|.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL
||  |||.||||||.|||||.|..|.|.| . ..||.. .|........| || |||||..||.|.| |.. .. .....|
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0045450 (Phosphotyrosine protein) phosphatases II 218-516 1.1e-97 322.8 In-house 3-304 (307) alignment 
Range on Protein: 218-516
Range on HMM: 3-304/307.0
VNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLL---GP
..   .....  |  ...   . ..|...|||.|....|. |. . ....|||| |||||.|||.||.||.|.  |.....||||||.|..  ||   . 
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

DENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQY
  . ...|| ||.|. ||.|||.| |.....|||| |..||.||.||..|||. | .  ||.. ||. .|.   .|..||| |..||  .  |...|..|
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

LSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
..|||||||. .  .|.|...... .|.||  ||..||||||.|||||.|......... . |  .|.|........|.||.|.||.. ||.|.| |...
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

FI
..
ll
subfamily_PTPRD_pd Subfamily PTPRD 237-526 2.1e-97 322.1 In-house 18-291 (564) alignment 
Range on Protein: 237-526
Range on HMM: 18-291/564.0
EDTAKAGFWEEFESLQKQevkNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKnqllGPDeNAKTYIASQGCLEATVNDFW
. . .. | ||.......   . ..  . . |.|| ||||.||...|||||.|.  . . .|||||||..|.    | . . |.|||.|| |. |..|||
kansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfid....gyr.krkayIAtqgPlaetiedFW

QMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGmQRAYGPYSVTNCGEHDTTEYKLRTLQVsPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI
.| |..||..||| |. .|||..||  |||| | .  || . ||   |.. ..| .||...    . .  ||. .... |||||||| .. ..|......
RmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkv

NQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVL
.. .|  |.||||.||||||.||||| ||||...| | .   . ..|| ......|.||  ||||| || ||. ||.....  ....|. 
ralne..pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevese
0050432 (Phosphotyrosine protein) phosphatases II 211-523 2.5e-96 317.9 In-house 12-306 (308) alignment 
Range on Protein: 211-523
Range on HMM: 12-306/308.0
QPYYATRVNAADIENRVLELNKKQESeDTAKAGFWEEFESLQKQEVknLHQRLEGQRPENKGKNRYKNILPFDHSRVILqgrdsNiPGSDYINANYIKNQ
.... | ... ... .||.| |. |.  . . ...|||| |... .  |...  ...|||| |||||.|||.|||||.|     . .|||||||.|..  
llfrdtsilvsslklsvldllkllek.aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....d.egsdYInAsyvdgy

LlgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLiRE
      . ...|| ||.|. ||.|||.| |..|.||||| |..||.||.|| .|||.   |  . ||...||.  |.   .|..|||....|..|.  |.
s...sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rt

IWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlphaGPIIVHCSAGIGRTGTIIVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFI
..|..|..|||||||..|  .|.||.........    |||.||||||.|||||.|..|.|.| . ..   . .|........| || |||||. ||.|.
vthfhytnWpdhgvPpspeilldflelvrkslpg....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylfl

YVAIAQFIETTKKKL
| |.. .... ..||
yralleylklkltkl
0036941 (Phosphotyrosine protein) phosphatases II 238-523 5.6e-94 310.0 In-house 9-284 (297) alignment 
Range on Protein: 238-523
Range on HMM: 9-284/297.0
DTAKAGFWEEFESLqkQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILqgrdSNiPGSDYINANYIknqlLGPDENAKtYIASQGCLEATVNDFWQ
 . .|....|||.|  .....|  .  ...|||. |||||.|||.||.||.|    .. .|||||||.|.     |.| . | .|| ||.|. ||.|||.
llflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....dd.egsdYinAsyv....dgydlkrk.fIatqgPlpntvedFWr

MAWQENSRVIVMTTREVEKGRNKCVPYWPEV-GMQRAYGPYSVTNCGEHD--TTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLD
| |..|..|||| |..||.||.|| .|||.  |    ||...||. ...    ..|.||||.|....||.  |...|..|..|||||||. |  .|.|..
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgnge.srtvthfhytgwpdhgvpespaslldfie

QINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL
....... ||  ||..||||||.||.||.|..|.... . .|   . .|| ......| || |.|||. ||.|.| |..... ... |.
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0051299 (Phosphotyrosine protein) phosphatases II 231-516 1.8e-93 308.4 In-house 18-286 (288) alignment 
Range on Protein: 231-516
Range on HMM: 18-286/288.0
NkkqeseDTAKAGFWEEFESLQKQEVKnlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIknqlLGpDENAKTYIASQGCLEA
        . ..|..|||| |... ..  ...  ...|||. ||||..|||.|||||.|.  |. ..|||||||.||     |  .. ...|| ||.|. 
l......angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyi....dg.ynlkrkfIatqgPlpn

TVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLD---NGDLIREIWHYQYLSWPDHGVPSEPG
||.|||.| |..|.||||| |..||.||.|| .|||. |    ||...||.  |.   .|..|||.|..||    ..  |...|..|..|||||||. | 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

GVLSFLDQINQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
 .|.|| .... ..  .. ||..||||||.|||||.|..|.|.| . ..     .|. ......| || |||||. ||.|.| |.. ..
llldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 242-529 4.5e-92 304.0 In-house 18-288 (317) alignment 
Range on Protein: 242-529
Range on HMM: 18-288/317.0
AGFWEEFESLQKQevkNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIknqlLGPDENAKtYIASQGCLEATVNDFWQMAWQ
 ...|||| |...   .|. . ....||||.||||..|||.|||||.|.  .. ...||||||.|.     ||... | .|| ||.|. ||.|||.| |.
talleefedllsl...kldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv....dgpnlkrk.fIatqgPlpntvedFwrmvwe

ENSRVIVMTTREVEKGRNKCVPYWPEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLdNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE
....|||| |...|.||.|| .|||. |    ||...||...|.   ...||||.|..| ...  |...|..|..|||||||. |  .|.||..... .|
qgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale

slPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIeTTKKKLEVLQSQ
  .. ||..||||||.|||||.|......| . ..|   ..|........|.||.|.|||..||.|.| |..... ..| .|| ....
..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl.krkltlepasel
0039614 (Phosphotyrosine protein) phosphatases II 237-520 2.3e-91 301.6 In-house 27-293 (297) alignment 
Range on Protein: 237-520
Range on HMM: 27-293/297.0
EDTAKAGFWEEFESLQKQEVkNlhqRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIknqlLGPDENAKTYIASQGCLEATVNDFW
  . | ....|||.|... . .   . ....|||| |||||.|||.|||||.|.. |.  ..||||||.|.     |.| . ...||.||.|. ||.|||
kansktllllefeellslkp.d...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFw

QMAWQENSRVIVMTTREVEKGRnKCVPYWPEVGMqrAYGPYSVTNCGEHDTTEYKLRTLQVSPldnGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI
.| |.....|||| |..||.|| ||..|||| |    ||...||. ...    |..||| |..   ..  |...|.||..|||||||. .  .|.||...
rmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelv

NQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK
......||  ||..||||||.|||||.|......| . ..   ...|........| ||.|.|||. ||.|.| |..... ...
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 238-516 9.4e-91 299.3 In-house 8-272 (273) alignment 
Range on Protein: 238-516
Range on HMM: 8-272/273.0
DTAKAGFWEEFESLQKQEVknLHQRLEGQRPENKGKNRYKNILPFDHSRVILqgrdsNIPGSDYINANYIknqlLGPDENAKtYIASQGCLEATVNDFWQ
 . .....|||| |... .  |. .  ...|||| |||||.|||.|||||.|     . .|||||||.|.     |.. . | .|| || |. ||.|||.
llgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv....dgynlkrk.fiatqgPlpntvedfwr

MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM--QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQ
| |..|.||||| |..||.||.|| .|||. |      ||...||. .|.    |..|||....|..|.  |...|..|..|||||||. .  .|.|...
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefiel

INQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
... .|.||. ||..||||||.|||||.|..|.|.. . ..|    .|. ......| || |||||. ||.|.| |.. ..
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
DSPc_SM00195 244-516 1.6e-89 295.1 In-house 2-262 (263) alignment 
Range on Protein: 244-516
Range on HMM: 2-262/263.0
FWEEFESLQKQEVKNlhQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN
..||||.|.... ..  .  |.....|| |||||||||.||.||.|. .... .||||||||||| .     .. |.||| ||.|. ||.|||.| |.|.
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvweek

SRVIVMTTREVEKGRNKCVPYWPEV-GMQRAYGPYSVTNCGEHDTT-EYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE
...|||.|.|.|.|..||  ||||  | .  .| .||..  .. .  |..||||...  .. .  |.. .||| .|||||||...  ||..| .......
vkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksks

SLphAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.    |||.||||||.|||||...||.........     .||.......| || |||||..||.||| ||...|
ts..sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 244-516 1.6e-89 295.1 In-house 2-262 (263) alignment 
Range on Protein: 244-516
Range on HMM: 2-262/263.0
FWEEFESLQKQEVKNlhQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQEN
..||||.|.... ..  .  |.....|| |||||||||.||.||.|. .... .||||||||||| .     .. |.||| ||.|. ||.|||.| |.|.
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvweek

SRVIVMTTREVEKGRNKCVPYWPEV-GMQRAYGPYSVTNCGEHDTT-EYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE
...|||.|.|.|.|..||  ||||  | .  .| .||..  .. .  |..||||...  .. .  |.. .||| .|||||||...  ||..| .......
vkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksks

SLphAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.    |||.||||||.|||||...||.........     .||.......| || |||||..||.||| ||...|
ts..sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 238-516 9.6e-86 283.0 In-house 16-277 (278) alignment 
Range on Protein: 238-516
Range on HMM: 16-277/278.0
DTAKAGFWEEFESLQKQEVknlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQ
 . |.....|||.|... .     .  ...|||| |||||.|||.|||||.|.  ..  ..||||||.|.        .  ...||.||.|. ||.|||.
lnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyv.....dgynvprkfiatqgPlpetvedFwr

MAWQENSRVIVMTTREVEKGRNKCVPYWPevGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN
| |......||| |..||.||.||..|||  |    ||...||. .|.    |..||| |..| .|   |...||.||.|||||||. .  .|.|| ...
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavr

QRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
...|  .  ||..||||||.|||||.|....|.| . . |    .|........| || |.|||. ||.|.| |.....
eale..dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 235-521 2.4e-85 281.1 In-house 18-290 (293) alignment 
Range on Protein: 235-521
Range on HMM: 18-290/293.0
ESEDTAKAGFWEEFESLQKqeVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVND
. .  ....| ||.|.|..  |.. ..    ....|. ||||.||||.||||| |.  . . .||||||||||...     .  . .||.|| |  ||.|
kmkadsdlrfseeyeelka..vgkdqavkaaelavnraknrytnilpydhsrvkLaalk.desgsDYinanyipgy.....nsprefiatqGPlpetvdd

FWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPldnGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLD
||.| |...|..||| |. ||||. ||  |||.   . .||  .||   |...... .|.|...    .. .|.. .|...||||||||...  .|.|. 
fWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvr

QINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
......|.  ...||.||||||.||||| | .|.|...|... .   .||  ... .| .|  .||||.|| ||. .. ........
tvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedy...vdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPN12_pd Subfamily PTPN12 237-521 5.3e-83 273.2 In-house 3-282 (290) alignment 
Range on Protein: 237-521
Range on HMM: 3-282/290.0
EDTAKAGFWEEFESLQKQEVK----NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATV
| .... | .||..|.|.. |    . ... .|...||. |||||.|||.|.||| |.  ... .||||||||.||.      |. ..|||.|| | .|.
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieee.egsdYinanfikgv.....egkleyiaaqgPLpktl

NDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA-YGPYSVTNCGEHDTT-EYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVPSEPGGVL
.|||.| |. | ...||  |||| |..||  |||| | ..  .|...||.  |. .. .. .|||.|    . .  |..  ..| .|||||||| .  .|
ddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkve...aqkesrkvyqfhYtaWPDhgvPssaksll

SFLDQINQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
.........||   .. |..||||||.|||||||.||.  | . .. .. ..|. . .. .| ||. .|||. ||...| |.|...... .
elielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 218-524 9e-83 272.9 In-house 2-288 (318) alignment 
Range on Protein: 218-524
Range on HMM: 2-288/318.0
VNAADIENRVLELNKkqesedTAKAGFWEEFESLQKQEVKNLhqRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdEN
... |.|..| .|..      . .  . ||.| |...| .    .|.   | || |||| |||..||.|| || .... .||||||||||        ..
isvedleshvrrlre......sGelllseeyerlsrseetvt..slkslepvnkaknryanilaydhtrvkLqmlege.egsDyinanyidGy.....rr

AKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPlDNGDLIREIWHYQYLSW
 |.|||.|. |  |..|||.| |. ||.|||| |.|.|.|..|.  |||. |  |.||   |.   | ....| ||...|.  .. .  |..  |.| ||
kkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsW

PDHGVPSEPGGVLSFLDQINQRQEsLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
||.|||......|... |... |.  . ||||.||||||.||||. |..|.|.| |   .|   .|. .|....| ||  ||||| ||.||| .. ....
pdegvpesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvlleala

TTKKKLE
. ... .
sgdtevd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 225-526 1.1e-81 269.4 In-house 12-293 (319) alignment 
Range on Protein: 225-526
Range on HMM: 12-293/319.0
NRVLELNKkqesedTAKAGFWEEFESLQKQEVKnlhQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIKNQllgpdENAKTYIAS
.|. .|..      |.. .. .||. |.. . .   .  . ...||| ||||.|||..|..||.|.  |  ..|||||||..|        .. . .|| 
erlkalas......tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgy.....qerekfiat

QGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPS
|. || |..|||.| |.|.| ..|| |. |||.. |.  ||||  .   || . ||   |. . .|  | |.. .. .    ||. |.||..||||.|| 
qaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPe

EPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLE
.  ..| .| .|.. .|  ...|||.||||||.||||| ||.|. .|...  |.   .|. .|....|.||  |||...|||||| |. ...|. . ..|
katslldllkrirksrek.tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

VL
| 
vq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 231-518 2.5e-81 267.9 In-house 10-281 (288) alignment 
Range on Protein: 231-518
Range on HMM: 10-281/288.0
NKKQESEDTAKAGFWEEFESLqkQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIKNqllgpDENAKTYIASQGCLEA
.| .. . ....|| ||..||   .... ..   |....|. ||||.||||.|. || |.. .   .|.|||||.||..     ... |.|||.|| | .
akvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkklee.eagaDYinasyidg.....ekkkkkyiatqgPlad

TVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVPSEPGGVL
||||||.. .....  ||| |  ||.|..||  |||. . .. ||   ||  ........ ||.| .         .|| .||||.|||||||     .|
tvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapll

SFLDQINQRQESLphAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET
 .|.|... ...   .||||||||||.||||| |..|.|.... .   .  ||.  |.. .| ||  .|||. || ||| .... || 
ellrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
0045098 (Phosphotyrosine protein) phosphatases II 260-518 6.5e-80 263.7 In-house 23-274 (278) alignment 
Range on Protein: 260-518
Range on HMM: 23-274/278.0
HQRLEGQRPENKGKNRYKNILPFDHSRVIlqgrdsnipgsDYINANYIKNQllgPdenaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN
 . .......|. |||||.|||.|||||.           |||||.||.     |    |..|| ||.|. ||.|||.| |.....|||| |..||.||.
seitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy...p....kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCVPYWPEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL---DNGDLIREIWHYQYLSWPDHGVPSEP--GGVLSFLDQINQRQE-----------SL
||..|||| |    ||...||.  |. . .| |||| |  |   ....  |...|..||.||||||||.|    .|..|..|.....            |
kcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

PHAGPIIVHCSAGIGRTGTIIVIDMLMENIstkglDCDIDIQKTIQMVRAQRSG-MVQTEAQYKFIYVAIAQFIET
.. ||..||||||.|||||........|..     .. .|........| || | .||.. ||.|.| ....... 
dsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
Y_phosphatase Protein-tyrosine phosphatase 270-513 7.1e-80 263.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 270-513
Range on HMM: 1-234/235.0
NKGKNRYKNILPFDHSRVILqgrdSNIPG-SDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP-E
|| |||||.|||.|..|| |    .. .| ||||||||.|.         |..||.||.|. |..|||.| |||...|||| |...||||.|| .||| |
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyke.....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

VGMQRAYGPYSVTNC-GEH-DTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQesLPHAGPIIVHCSAGIGRTGTIIV
 . .  || ..|..   |. |..|| ||.|...  .. .  ||.....| .|||||||..| ..|..........   .. ||..||||||.|||||...
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfva

IDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA
.|.|.|......    .|. ......|.|| ||||...||.|.| ||.
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 270-513 7.1e-80 263.2 In-house 1-234 (235) alignment 
Range on Protein: 270-513
Range on HMM: 1-234/235.0
NKGKNRYKNILPFDHSRVILqgrdSNIPG-SDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP-E
|| |||||.|||.|..|| |    .. .| ||||||||.|.         |..||.||.|. |..|||.| |||...|||| |...||||.|| .||| |
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyke.....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

VGMQRAYGPYSVTNC-GEH-DTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQesLPHAGPIIVHCSAGIGRTGTIIV
 . .  || ..|..   |. |..|| ||.|...  .. .  ||.....| .|||||||..| ..|..........   .. ||..||||||.|||||...
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfva

IDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA
.|.|.|......    .|. ......|.|| ||||...||.|.| ||.
ldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0037934 (Phosphotyrosine protein) phosphatases II 265-515 1.9e-79 261.9 In-house 5-241 (243) alignment 
Range on Protein: 265-515
Range on HMM: 5-241/243.0
GQRPENKGKNRYKNILPFDHSRVILqgrdsniPGSDYINANYIKNQllgPdenakTYIASQGCLEATVND----FWQMAWQENSRVIVMTTREVEKGRNK
...|||. ||||..|||.|||||.|       .||||||||.|.     |     ..||.|| |. ||.|    ||.| |.....|||| |..||.||.|
allpenlsknrysdilpydhsrvkl.......egsdyinanliyvt...p.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrek

CVPYWPevGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES------LPHAGPIIVHCS
|..|||  | .  ||...||. .|. . .|..|||....|| .|| |...||.||.|||||||..|  .|.|||.... .|.      |.. ||..||||
caqywp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGIGRTGTIIVIDMLMENIstkgldcDIDIQKTIQMVRAQRSG-MVQTEAQYKFIYVAIAQF
||.|||||.|.........       ..|........|.||.| .|||. ||.|.| |....
aGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 264-516 3.2e-79 261.3 In-house 5-246 (249) alignment 
Range on Protein: 264-516
Range on HMM: 5-246/249.0
EGQRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIKNQLLGPDenaktYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
....|||| ||||..|||.|||||.|.  ..  ..||||||.||.    ...     .|| ||.|. ||.|||.| |.....|||| |..||.||.|| .
vallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrr.....fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaq

YWPEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLdNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTI
|||. |    || ..||.  ..   .|..|||....|   .  |...|.||..|||||||. .  .|.|...... .|.||  ||..||||||.|||||.
ywpl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
|......| . ..   ...|.. .....| ||.|.||.. ||.|.| |.....
iaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 266-516 4.1e-79 260.7 In-house 5-243 (245) alignment 
Range on Protein: 266-516
Range on HMM: 5-243/245.0
QRPENKGKNRYKNILPFDHSRVILQGRDSnIPGSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW
..|||| ||||..|||.||.||.|.  ..  ..||||||.|.     . ..  ...||.|| |. ||.|||.| |......||| |.|.|.||.|| .||
llpenkdknrysdilpydhtrvklspdgg.dldsdyinasyv.....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPlDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTIIV
|. |    || ..||. .|.   .|..|||.|.. .  |  ||..||.||.|||||||. .  .|.||. ... ... .  ||..||||||.|||||.|.
pl.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

IDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.....| . .    ............| ||.|.|||. ||.|.| |.....
aylmleqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRG_pd Subfamily PTPRG 240-529 3.4e-74 245.0 In-house 17-300 (563) alignment 
Range on Protein: 240-529
Range on HMM: 17-300/563.0
AKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMA
.. || ||||.||.. ...  .    |.|||| |||| ||...|.||| |..   .    ||||||||.       . .| .||.|| |. |..|||.| 
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy.....qkskafiatqgplkdtfddFWrmi

WQENSRVIVMTTREVEKGRNKCVPYWPEvGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSP--LDNG---DLIREIWHYQYLSWPDHGVPSEPGGVLSFLD
|..|. .||| |  ||.||.||  |||.      ||  .||   |. .. |  |||..    |...   |  ... .|.| .|||||||. .  ||.|  
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

QINQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ
. .. ..   .||||.||||||.||||| ||.| |...| ..     ... ......||||  .|||| || |.. |. . | . ...|   | .
kssaank..aeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_PTPN13_pd Subfamily PTPN13 246-517 4.8e-74 244.1 In-house 15-270 (273) alignment 
Range on Protein: 246-517
Range on HMM: 15-270/273.0
EEFESLQkqEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgsdYINANYIKNQLlgpDENAKTYIASQGCLEATVNDFWQMAWQENSR
|||. |.  |.| | .  .|.. ||| ||||.|.||.|..||.|..  .      ||||..|| ..   ...  .|||.|| |  ||.||||| |. ...
eefkelr..elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpv...gkdeyeyiacqGPlPetvkdfwqmvweqkae

VIVMTTREVEKGRNKCVPYWPEVGMQR--AYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEsl
||.| | |.|||. ||  ||||   ..  ... . |.. .  .  ....|.|.|. .. |.  ||. | .. .||||||||..  .| |. .... |.  
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesge.srevahlnfvkwPdhgvPssaaellqfvaevrrlqt..

pHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
 .||||.|||||||||.||.|.||.... |. .    ..|...... .| || |.|||. || |.| || . ..
.dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 226-520 7.3e-74 243.7 In-house 13-294 (298) alignment 
Range on Protein: 226-520
Range on HMM: 13-294/298.0
RVLELNKKQEseDTAKAGFWEEFESLQKQEV--KNlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKnqllgPDENAKTYIA
 . .|.....  ..  .|. .||. |.. .   .. ..   ...|||| |||| .|...|.|||.|.  |..   |||||| ...       .. ...||
alqklaavkk..kkkltgyalefqrlnsvsseiee.eekevarkpenkkkNRyadiialdssRvvLekedad.eesdYiNAsflh.....aykgrnafia

SQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGdLIREIWHYQYLSWPDHGVP
.|. |..||.|||.| ..|.. .||| |  .|... |.  |||..|  . ||  .|.   ... ...  |.|.||  ..    ||. . .. ||||.|||
tqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvp

SEPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK
..   || .|..... |.      |.||.||||.||.|| |.|| ..| . .   .  .|. ......|..| |.||||.||.||| |. ..... .
enatsvldllrkvrasqqq.agnkpvivqCsaGvgRsGtfiaidsvlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 234-519 1.5e-73 242.4 In-house 7-279 (281) alignment 
Range on Protein: 234-519
Range on HMM: 7-279/281.0
QESEDTAKAGFWEEFESLQKQEVKNLHQrlEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINANYIKNQllgpdENAKTYIASQGCLEATVN
.. ..  .||| ||.|.|.. .|.|  .    ...||. ||||.||  .|..|| ..  ..|   .||||||...       .. | |||.|| . |...
kqlsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenk.ntDYinanfvpgy.....kgekeyiatqgPvPaslv

DFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVsPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFL
.|||| |... ..||| |||.|.|. ||  |||.   .  || . |..  |.....|  |....   ..|.  ||. . .|..|||||||...  .|.| 
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresge.treveqlaytaWPdhGvPattkellefr

DQINQRQESLPHaGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
..... .|.  .  |...|||||.||||| | .| |.......    ..|.. ... .| .|  |||| .||.|.| |. . .. .
kevlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaele..eldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPRA_pd Subfamily PTPRA 228-539 1.6e-73 242.5 In-house 19-318 (330) alignment 
Range on Protein: 228-539
Range on HMM: 19-318/330.0
LELNKKQESEDTAKAgFWEEFESLQKQEVKNLHQRleGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKnqllGPdENAKTYIASQGC
|| . .. | | .|  | |||..|   ....  .    .. ||| |||. ||||.|.|||||. ..  .. |||||| .|.    |  .. ...||.|| 
leeeirirsaddnkl.freefnalPagpiqatlel..askeenkeknrvvnilPydfsrvilsvke.Gveesdyinasfid....Gy.kekdkfiaaqGP

LEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPLDN---GDLIREIWHYQYLSWPDHGVPS
.| ||.|||.| |. .|  ||| |   |. ..||  |||. |.  .||   |.   |  . .| .| . |  | .    .  | .  . . |||| |||.
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

EPGGVLSFLDQINQRQESlpHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLE
|| |.|..| .... ..   .||||.||||||.||||| ||.| ..| . ....   .|. .... .|.||. ||||. ||.||| .. ..      .|.
epiGmlkllkkvkklnqq..sagpivvhcsaGvGrtGtfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

VLQSQKGQESEYGNI
|   .|  .. |..|
vsslekhlqklynki
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 264-519 6.4e-73 240.2 In-house 22-271 (274) alignment 
Range on Protein: 264-519
Range on HMM: 22-271/274.0
EGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKnqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVP
| . . .. |||||.||| ..|||.|. ..|. . |.||||||||    |.||. |.|.| || |  ||.|||.| .||...||||.|.  |. ..||. 
eldvfgsqtknryktilPnensrvllesessededssyinanyik....GydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPEVG---MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgdlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ-RQESLPHAGPIIVHCSAGIGR
|.|.     ..  ||  .... .  .. .|..|.| .. | .    |.. || | .|||| .| ..  .|........ |.|.  ...|..|||||||||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
||  | |.. . ..     .  .|. |..  .| .| |||||. ||..|. |.... . .
tGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_PTPN9_pd Subfamily PTPN9 237-519 1.6e-72 239.1 In-house 11-293 (297) alignment 
Range on Protein: 237-519
Range on HMM: 11-293/297.0
EDTAKAGFWEEFESLQKQEVKNLHQRleGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFW
... | |  .|.. .....|.   ..   . . |  ||||...| .|..|| |. .| . . |||||||..        .. |..|| || |. ||.|||
kekgkrGlskeyaeirnepveGtfla..sklranleknrytdvlcydetrvvlakvded.easdyinanfvdGy.....kqkkafiatqGplkktvsdfW

QMAWQENSRVIVMTTREVEKGRNKCVPYWP-EVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQ
.| |... .||||||| ||.|| ||  ||| | . .  .| .||.|   . . .|| |.|...  .... .|.. |.|.|||||.||||.   .| .|..
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlek

INQRQESL-----------PHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
. ..| ..           |.  ||.|||||||||||| | .|. .... ..|    .|...|....|.||. ..||. ||.| |.|. ..  ..
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN3_pd Subfamily PTPN3 248-516 3.5e-70 231.1 In-house 21-275 (280) alignment 
Range on Protein: 248-516
Range on HMM: 21-275/280.0
FESLQKQEVKnlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgsDYINANYIKNQLLGPdENAKTYIASQGCLEATVNDFWQMAWQENSRVI
|| | ... .   .  . ..|||  ||||..|||.|. ||.|.  ..     |||||||.. .. .  .  . |||.|| |. |..||||| |...|..|
feqlyrkkpg..laisaarkpenlsknryrdilpydatrvklkeset.....dyinanyvnmeipst.glvnryiatqGPlaktatdfWqmvweqkssli

VMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlpHAG
|| |  ||.|| ||  |||| . .  || .||.   |. |..| || | ..  .. .  |.| . |||.|||||||...  .|.|...... ...  .  
vmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsg..kee

PIIVHCSAGIGRTGTIIVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
|..||||||||||| .|.... .  | ..    .. . . ....| ||. .|||..||||.  || .  
PvvvhCsaGigrtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN14_pd Subfamily PTPN14 242-519 7.3e-70 230.3 In-house 23-299 (300) alignment 
Range on Protein: 242-519
Range on HMM: 23-299/300.0
AGFWEEFESLQKQEVKNLHQrlEGQRPENKGKNRYKNILPFDHSRVILQGRDSNipGSDYINANYIKNQLLGpdeNAKTYIASQGCLEATVNDFWQMAWQ
.  . |.| ..|.. . | .   .. |||. |||.|..||....|| |.    |   ..||||  || .. |   . ..||..|| || ||.||||| |.
gkvfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvgg...kersyivaqgPleltvqdfWqmvWe

ENSRVIVMTTREVEKGRNKCVPYWPEVGM---QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ
.. ..||| |.| |.|..|.. |.|. .    .  .| . ||.   .|.. .  ..|..  |  ..  |..|| ||  |||||||... | ||.|.... 
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske.ertvwhlqytDWpdhgvPeDvkgflsyLeevqs

-------RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
        .||  .  |..||||||.|||| .|. |.|.. . .   . .|||.|.....| ||  .||| |||||.| .. .... .
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Ptp69D_pd Subfamily Ptp69D 235-524 2.3e-69 228.8 In-house 15-294 (307) alignment 
Range on Protein: 235-524
Range on HMM: 15-294/307.0
ESEDTAKAGFWEEFESLQKQEVKnlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVND
 ..  .. |. .|.|.|...|..  ..   ... ||. ||||..| .||. ||.|.    .   ||||||..||       .. |..||.|. .|||..|
srkrdtdfglakeyekLeareid..kstkvsekkenalknRyedikafDktRvkLkkingk.edsdYinasfikgy.....kekkkfiaaqdPveatigD

FWQMAWQENSRVIVMTTREVEKGRNKCVPYWP-EvgMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLD-NG---DLIREIWHYQYLSWPDHGVPSEPGGV
||.| .. .. .||| . . || |.||  ||| |   .  ||   |.   |. ...|  |.|.||  . ..   .  |..  |.|..|.|  ||  . |.
fWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

LSFLDQINQRQESLphAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLE
| ...|... ..     .||.|||||| ||.|... .|.|.... .   .  .|| .|.. .| ||. .||  .||.|.| |...... ..   .
lklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlka...edkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtded
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 269-521 5.2e-69 227.2 In-house 19-269 (270) alignment 
Range on Protein: 269-521
Range on HMM: 19-269/270.0
ENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKnqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
 .|  |||..|||  ..||.|.  ... . . ||||||..    | |.. |.|||..| |..|...||.| |.|... |||||  .||||.||  |||. 
rgkklnRyadiLPsPatRvrleeleed.sataYinAnyvr....GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

GMQ---RAYGPYSVTNCGEHDTTEYKLRTLQVSplDNGDLIREIwHYQYLSWPDHGVPSEPG------GVLSFLDQINQRQESLPHAGPIIVHCSAGIGR
  .    ..|  .|... |. .. | |. |..   ..|.  | . |..| .|||||||.|..       .|. | .. . ...| .|.|..||||||.||
pkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
|||.|..|. .. .....    .|. . |. .| .|  .||.  ||.|.| |.....|...|
tGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_PTPN1_pd Subfamily PTPN1 243-521 9.2e-69 226.3 In-house 6-276 (290) alignment 
Range on Protein: 243-521
Range on HMM: 6-276/290.0
GFWEEFESLQKQEVKNLHQRlEGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgsDYINANYIKNqllgpDENAKTYIASQGCLEATVNDFWQMAWQE
 ...|.    ..| .....| | ..|||...|||... |.||||..|.  |      |||||. ..      .|  . || .|| |  ||. |||| |..
rlykeiyldirkeasdfptr.eaklpenrnlnryrdvspydhsrikleradn.....dyinaslvel.....eeakrsyiltqGPlpntvdhfWqmvWeq

NSRVIVMTTREVEKGRNKCVPYWPE----VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQ
.|. .||  . |||...||. |||.      ..     ..|.   |... .|..|.|..  |   .  ||| |. |..||| |||. |.  |.|| .. .
kskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe.treilhfhyttwpdfgvpespaaflkflfkvre

RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
     .. || ..||||||||.||....| .. .|  |.    .||.|..  .| .| |..||  | .| |.|| . . . |.
sGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 236-521 1.6e-67 222.8 In-house 16-288 (305) alignment 
Range on Protein: 236-521
Range on HMM: 16-288/305.0
SEDTAKAGFWEEFESLQKQEVKNLHqrleGQRPENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDF
.. . . |. ....||...| ..      |.. .|| |||.|.| ..|..|.||. ..|.   ||||||.|..       .. |.||..|| |. ||.||
arvysdkgleaqykslyeeeesidv....gkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgy.....krkkkyivaqgPlkntvadf

WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLD
|.. ..|  ..||| |. || |..||  ||||    .. .|..||.   |. ...|  | |..|  |. .  | . .||  .||||||| ... .||...
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

QINQRQESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
.....|..  .  |..||||||.||||. |..|. .| . . .    .|. . .. .| .| .|||| .|| |.. |... |.... 
rvqkdqkk.dkgvpllVhCsagvgRtGvfiavdialerlkkEe...vvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_PTPRK_pd Subfamily PTPRK 241-514 3e-67 221.7 In-house 21-275 (314) alignment 
Range on Protein: 241-514
Range on HMM: 21-275/314.0
KAGFWEEFESLQKQevknlhqRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQMAW
  || ||.||| .            .. ||. |||...||..|.|||.|.  | . | ||||||..|        .... .|. || |. ||.|||.. .
gygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgd.pssdyinaali.....dsykrpaafivtqgPlqetvkdfWrlvy

QENSRVIVMTTREVEKGRNKCVPYWPEVGMQraYGPYSVTNCGEHDTTEYKLRTLQVSPLDN-GDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR
.||.  ||| |  ||.|| ||. |||| ...  ||.  |.    .  .|.  |...|. |    . |||. ..|.|.||||.|| .  |.|... .... 
dencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkks

QESlpHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
||   .||.|.|||||| ||||| |.||.... | ..|.   .|. .... .|.... ||.|| |||||| .| .
qee..eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 265-519 1.1e-65 216.3 In-house 4-245 (250) alignment 
Range on Protein: 265-519
Range on HMM: 4-245/250.0
GQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpDENaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNkCVPY
...|.|| |||| .|...|.|||.|.  .     |||||| ...      ||. |..||.|| |.||..|||.| ..|.| .||| |  .|.... .  |
akkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgy....der.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPeVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTII
|| |   . ||   |.   ..  ..|. |.|..|   . |  | . ......||| ||| .   || .|..... |.   ...|.||.||||.||.|. |
wP.vekaekyGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafi

VIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
.|| ..|.. .   .  .|. | |...|..| ..|....|| |.| .| ......
aidavlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 218-514 1.9e-65 216.3 In-house 11-289 (319) alignment 
Range on Protein: 218-514
Range on HMM: 11-289/319.0
VNAADIENRVLELNKKQESEDTaKAGFWEEFESLQKQEVKNLHQRlEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdEN
|   |..   ..| .|.. .|  .  .. ||  . |. |.   |      ..|| |||. |||.||...| |.  .  . .|||||| ...        .
vavpdfpayyqqlsnksdfddd.ltklevefrracklgvnladqt.fanldqnkdknriinilafdknvvklerli.GeefsdyinasfvtGy.....qr

AKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTrevekgRNKCVPYWPEVGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW
 . |||.|| |. |..|||.| |. |.  ||. |      ..||  |||  . .  .. . |     ..| || .| ...|   .   ||.|  . .| |
kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGw

PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
||.|||  |  .. ......  ..   |  .|.||||||.||||. ||.|.|.. .     .  .|. .... .| ||. .||  .||||||.|. .
pdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 269-512 4.6e-65 214.2 In-house 2-235 (237) alignment 
Range on Protein: 269-512
Range on HMM: 2-235/237.0
ENKGKNRYKNILPFDHSRVILQGRDSNipgSDYINANYIKNQllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
||| |||| ||  .|||||.|.|  |.   ||||||.|.|.     |   |.|||.|| ||.. .||||| |||.  |||| |  .|. . ||  |||. 
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkgf....dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst

GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDM
   .||| ..|. . . . ..| .|.| .|   .   .| |. ||. ||||.||| .   .| |  .| .| . ....|| |.|||||.|||| ..||| 
dqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida

LMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI
.. .   | .   .|| . .. .  .|  ..||. || ||. .|
mlrqakekkv...vdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 238-513 6.5e-63 207.6 In-house 20-277 (315) alignment 
Range on Protein: 238-513
Range on HMM: 20-277/315.0
DTAKAGFWEEFESLQKQEVKNLHqrlEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQ
 ..| || ...||.   ... |.     .. ||| |||| ||...|.||| |   . | |.|||.|||.|.       .  . |||.|| . |.|.|||.
astkngfkqdyesipggqlhpld...vakkienkqknryiniiaydksrvqlplle.ndphsdyvnanfidGy.....nkkrryiaaqgpnvasvkdfwr

MAWQENSRVIVMTTREVEKGRNKCVPYWPEVgmQRAYGPYSVTNCGEHDTTEYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQIN
. ..|.   ||| |  ||. ..|.  |||.   .  ||...||   |   |||  ||| |     || |||.  ..| |||| |||     .. .  ...
lvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvv...fgdnirevvqlhytswpdmgvpkytiplmnlirtvk

QRQESlpHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI-A
| ...   .|.|.||||||.||||| | .| ..... .. .   ||. . |. ||..| .|||. .||.||| |.  
qhhtn..svgaivvhcsaGvGrtGtfitldavldqaeaena...idvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 242-517 1.1e-61 203.4 In-house 19-278 (315) alignment 
Range on Protein: 242-517
Range on HMM: 19-278/315.0
AGFWEEFESLQKQEVknlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQ
| | |||  |   ..   ...  .. ..|  |||||||||.|..||.|.  | ..| |||||| |||       .. |.|||||| |.|.|.|||.| .|
alfseefhdlpdPdi...yrqrvaretinfkknryknilPldsarvklevid.dsPdsdyinasyiksv.....dddkayiasqgPlkasvddfwrmvlq

ENSRVIVMTTREVEKGRNKCVPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLqVspLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQ
|.   ||| |   |  . ||  |||.  .    .| ..|.    . .|.   | | |  . ...  | .  .|.  |||.||. . . .| .. ..   .
ekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.v..trkseesrtvtqfqftewPdkGvdkqtssllklikevkadn

ESLPHagPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
..  .  ...||||||.|||| .| ||  ...|  .     .|. ......||.|  .|||| .| ||| |. . . 
gkkef..sllvhcsaGvGrtGvvisidevvaqikrtr...svdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN23_pd Subfamily PTPN23 229-520 1.3e-61 202.9 In-house 5-284 (288) alignment 
Range on Protein: 229-520
Range on HMM: 5-284/288.0
ELNKKQESEdtaKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQgrdsnIPGSDYINANYIKNqlLGPdeNAKTYIASQGCL
||..|. ..   |... ..|. |.... |. ..|       .  |||...|||.||.|| |.         ||||| ..|.  | |   . ..||.|. |
elqrkmldg...ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkd..lsp..gcPdfiatqaPl

EATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNgDLIREIWHYQYLSWPDHGVPSEPG
. |.||||.| ... |.|||| . . |.|..|.  ||||  |    .|..|||   ...| ..  |.|... ||. | .... | |. |||..|||. |.
qstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPe

GVLSFLDQINQ--RQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENIsTKGlDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK
 .| |||....  ...  .   |..||||||.||||.. ..   .... .|| .  .|| . .. .|.||  |||...|.|| | |. . .. . 
tllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekg.nglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 247-514 1.3e-61 203.7 In-house 3-253 (284) alignment 
Range on Protein: 247-514
Range on HMM: 3-253/284.0
EFESLQKQEVKNLHQRLeGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRV
||  . |. |.   |      ..|| |||. .||.||...| |.  .  . .|||||| .|.        . . |||.|| |. |..|||.| |. |.  
efrracklgvngtdqtf.anldqnkdknrighilafdknvvklerli.GeefsdyinasfitGy.....qrkdkyiatqGPldntladfWrmiweyncst

IVMTTrevekgRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA
||. |      ..||  |||  .    .. . |     ... || .| ...|   .   ||.|  . .| |||.|||  |  .. ......  ..   | 
ivllt......kdkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhr

GPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
 .|.||||||.||||. ||.|.|.. .     .  .|. .... .| ||. .||  .||||||.|. .
anivvhcsagvgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 243-516 2.7e-61 202.2 In-house 19-276 (515) alignment 
Range on Protein: 243-516
Range on HMM: 19-276/515.0
GFWEEFESLQKqevKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQE
 | |||  |      |.. .   |   |  |||||||||.| .||.|.  . | | |||.|| ||.       .| |.|||||| ..|.|.|||.. .||
lfseefhdlpg...pniypqtvaqeeinfkknryknilPydsvrvklevindn.Phsdyfnasyipsf.....dndkayiasqgPnkasvddfWrlvlqe

NSRVIVMTTREVEKGRNKCVPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVspLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE
|   |.| |.  |  . ||  |||.  |    .| ..|     .  |.   |.|.|  | . | .| .  ...  |||.||| .   .| .. ..   ..
nvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhg

SLPHagPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
 . |  |.|.|||||.|||| .| ||  . .. |      .|. .... .|..|  .|||. || ||| |. . .
qyth..pliihcsaGvGrtGvvisidsvvahakttrm...vdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 238-519 1.5e-60 199.5 In-house 16-286 (290) alignment 
Range on Protein: 238-519
Range on HMM: 16-286/290.0
DTAKAGFWEEFESLQKqeVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIP-GSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFW
 . . || ..|..|..   .. |.   |  ..|| .||..||.. |  |..|.   ..     .|||| |||.      ...| ||| || .. |. |||
akgnegfrnqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy.....kekkqyiatqgpvsntlvdFW

QMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRaYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI
.. |||.. .||| | ..|.|..||  |||. . .. ||..|..   |. ..||  |.|.|   ....  ... .||  .|...|   .| ..|. . ..
kliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

NQRQeSLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
.. |   .  ..|.||||...||... ..... ..   |.|    ||. . ..  | |. |.|||. ||..|.  . . ... 
yktq.rkrgntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPRN_pd Subfamily PTPRN 246-517 4.6e-60 197.8 In-house 33-293 (297) alignment 
Range on Protein: 246-517
Range on HMM: 33-293/297.0
EEFESLQKQEVKNLHQrLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpDENAKTYIASQGCLEATVNDFWQMAWQENSR
.|.|.| . | ..  .   .....|  |||.|..||.||||| |. .  .   ||||||  | ..    |  | .|||.|| | .|| ||||| |.. . 
kewealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeea.saeksdyinasaildh....dprapayiatqgplastvadfwqmvweqGvv

VIVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHD-TTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlp
|||. ||  |.| ..|  |||. | .  |. | |    ||  . .| .|.. .  |.. .  | .  . .||||..|||...  .| |  ..|.      
vivnltrleeegvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPasaksllefrrkvnksyrG..

HAGPIIVHCSAGIGRTGTIIVIDMLMENIsTKGLDcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
 . ||.||||.| ||||. |.||...... .||.  .|||  |.. .| ||.|.|.|..|..|.. |.|. ..
rscpivvhcsdGaGrtGvyilidlvlnrl.lkGvk.eidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 269-520 2.8e-59 195.2 In-house 37-281 (287) alignment 
Range on Protein: 269-520
Range on HMM: 37-281/287.0
ENKGKNRYKNILPFDHSRVILQGRDSNipGSDYINANYIKNQllgPDENakTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
 .  |||| ..||.|..||.|        |||||||||.       |..  ..||.|| . |||.|||.. ....| .... |||||..|.||  |||| 
aavkknryadvlPiddtrvllsaegel..Gsdyinanyvasy...tdde..afiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

GMQRAYGPYSVTNCGEH-DTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR---QESLPHAGPIIVHCSAGIGRTGTII
 .    | |||.         ||  |.|..  |.  .  | .  ...|||||....    |.. |  ...|.   . .   .||..||...||||.|...
evPmrvGGysvvlldydikePeygvralrlidletre.arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

VIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK
 . .|..     |    .|. ...  .| .| ..||.  |....| |.. . .|  
atlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 234-519 3.6e-59 195.5 In-house 17-291 (325) alignment 
Range on Protein: 234-519
Range on HMM: 17-291/325.0
QESEDtaKAGFWEEFESLQKQEVKNLHqrlEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNqllgpDENAKTYIASQGCLEATVN
....|  . ||  ||. |  .. .  .      .|||| |||.||....|.|||.|. .. . | ||||||.|...     | . ....|.|  | ||.|
kkaqd..qdgfahefgllpsddgiakk...vamkpenkaknrfknvvaldksrvvletkk.ddpssdyinasylrd.....dkkkdvflaaqaPltatin

DFWQMA--WQenSRVIVMTtREVEKGRNKCVPYWPEV-GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVL
|.|...  |.  . |.|..  |...| ..|  |||.  |  . .|.  |      . ..|  | |.|   ..|.  | .  .|. ||.| ||.  |  ..
dlWrlvldWr..csvvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe.trsvkqfqlqswddmGvqkrpatli

SFLDQINQRQESLPH----AGPIIVHCSAGIGRTGTIIVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
|.|. ... .| .      ..||.||||||.||||. | .  ..... .   .  .|| . .. .|..|  ||.|  || .|| |..... . 
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 236-521 2.1e-57 189.3 In-house 14-283 (287) alignment 
Range on Protein: 236-521
Range on HMM: 14-283/287.0
SEDTAKAGFWEEFESLQKQEvKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDsnipgSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDF
 ... . || . |  |.. . .. ..   .  ..|| |||...||. |  ||.|.|..      ||||| .|.       ...| .|.... .  |. .|
ghakgnegfknqftvleqvt.qredevthniasqnkdknRltqilvpdnyrvllkgeh.....pdyinavfidgy.....kekkafiiaesPmfntarnf

WQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQ
|.. ...|  .||| ..| |. ...|  ||||      .|.|...   |. ...|  |.|.|   .. .  ...  ||. .|...|  .||  .|  ...
WkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

INqRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKK
 . ...  .  ..|.||||...||... . ... ...  | |    ||. . ..  | |. |.||| .|||||. .. ..... . 
my.ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 269-523 2.4e-57 189.3 In-house 47-291 (297) alignment 
Range on Protein: 269-523
Range on HMM: 47-291/297.0
E---NKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKNqllgpdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRnKCVPYW
|   |  |.|||||||.| |||.|. .... | |||.|| ..|        | . .|..|   .|||.|||.| ..|.  .||| . . |. . ||  ||
ekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvkg.......nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PEVGMQRaYGPYSVTNCGEHDTTEYKLRTLQVSPlDNGDLIREIWHYQYLSWPDHGVPS--EPGGVLSFLDQINQRQESLPHAgPIIVHCSAGIGRTGTI
.. |..  .|  ||.    .. . .  |.|.|.  ..    | .  ||...|||. |.   .   .| .......  ..  .. |..|||.||.|||| .
sdkgvtt.fGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvl

IVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKL
. ||  . ..  .    ..|| ......| .|  .|||. ||||.|||. ... . . ..
ltidsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri
0051429 (Phosphotyrosine protein) phosphatases II 296-518 2e-56 186.9 In-house 1-227 (272) alignment 
Range on Protein: 296-518
Range on HMM: 1-227/272.0
IPGSDYINANYIKNQllGPDENAKTYIASQGCLEATVNDFWQMaWQENSRVIVMTTREVEKGRNKCVPYWP-----------EVGMQRAYGPYSVTNCGE
.| |.||||....    |     .....|.|.|..|..|||.. .... ..||. ..|.|.||.|| .|||           .. ..  || ..||.  |
lplsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPggVLSFLDQINQrqeslphAGPIIVHCSAGIGRTGTIIVIDMLMENIstkGLDCDID-
. .. | ||.|... | . . .||..|..|..|||||||.|.  .|..|.....        ||..||||||..||||......|....   .|.. .| 
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgv...sletivdd

-------IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET
       ........|||| |.||||.||.|.| |.......
Ylltnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 269-512 3.2e-55 181.9 In-house 6-236 (239) alignment 
Range on Protein: 269-512
Range on HMM: 6-236/239.0
ENKGKNRYKNILPFDHSRVILQgRDSNIPGSDYINANYIKNQllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
 || |||| ||. .|||||.|. . || | ||||||.|...     | . |.|||.|||.|..  |||.| |||   |||| |  .|  ..||  |||. 
vnkaknryanivtydhsrvvle.klsndphsdyinasylrdy....dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GmqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINqrQESLPHAGPIIVHCSAGIGRTGTIIVIDM
     |    ||       ..| .||. .| . . .  | ...|..  |||.|||     || .  .|   ..||| | | ..|||||.||||...||| 
t..skycnlrvtlrktevfadyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgarpwvihcsagvgrtgaflvida

LMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI
.. .      .  .|| . .. .| .|  ||||  || ||..|.
mlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 269-512 3.3e-55 181.8 In-house 7-237 (239) alignment 
Range on Protein: 269-512
Range on HMM: 7-237/239.0
ENKGKNRYKNILPFDHSRVILQgRDSNIPGSDYINANYIKNQllgpDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
 || |||| ||. .|||||.|. . || | ||||||.|...     | . |.|||.|||.|..  |||.| |||   |||| |  .|  ..||  |||. 
vnkaknryanivtydhsrvvle.klsndphsdyinasylrdy....dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GmqRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINqrQESLPHAGPIIVHCSAGIGRTGTIIVIDM
     |    ||       ..| .||. .| . . .  | ...|..  |||.|||     || .  .|   ..||| | | ..|||||.||||...||| 
t..skycnlrvtlrktevfadyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkit..kdslpgarpwvihcsagvgrtgaflvida

LMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI
.. .      .  .|| . .. .| .|  ||||  || ||..|.
mlrqakk...qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 266-512 5.1e-53 174.9 In-house 29-291 (297) alignment 
Range on Protein: 266-512
Range on HMM: 29-291/297.0
QRPENKGKNRYKNILPFDHSRVILQGrdsNIPGSDYINANYIKNqllgPDENAK-TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPY
.|.    ||||..|| .| .|| |..    |...|||||.|.      |||.|.  || .|| |.|||.|||.. .... ||||| ..  | ||.||.||
krnsslrknryrdilatddtrvkllr...viterdyinadyvvf....pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapy

WPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSF-----------------LD--------QINQR
||.|  .|   .  | .   . . |..   |    |   .  | . | |.||||||||||.   .  |                 ..        |..  
wpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

QESLPHAGPIIVHCSAGIGRTGtIIVIDMLMENISTKGLDCdiDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI
.   |   ...||||||.||.| ..|  . . ..  |.     |..  ....| ||. .|||  |....| |.
raemprnayllvhcsaGvGrsG.vvvlsdvilaklrkkrip..dvaailsilreqrarlvqtleqfellydav
0041856 (Phosphotyrosine protein) phosphatases II 270-517 2.2e-51 169.3 In-house 1-172 (182) alignment 
Range on Protein: 270-517
Range on HMM: 1-172/182.0
NKGKNRYKNILPFDHSRvilqgrdsnipGSDYINANYIKNQLLGPDenaktYIASQGCLEATVNDFWQMAWQENSRVIVMTTrevekgrnkCVPYWPevg
|. ||||..|||.||||           ..||||||..   | . .     .|| || |  ||.||..| .... ..||. |         ...|||   
nldknrysdilpydhsr...........dldyInanlylgslpatr.....fiatqgpllstvadflrmlkelgittivnlt.........eelywp...

mqraygpysvtncgehdtteyklrtlqvspldnGDLIREIWHYQYLSWPDHGVPSePGGVLSFLDQINQrqeslpHAGPIIVHCSAGIGRTGTIIVIDML
                                  .| |....|.||.|||||||. .  .|.|......      . ||..||||||.|||||.......
.................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylm

MENistkgldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
...        ..........|| .|.|||.|. || |.. |. ....
kkl........gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 243-512 1.3e-50 166.9 In-house 7-262 (283) alignment 
Range on Protein: 243-512
Range on HMM: 7-262/283.0
GFWEEFESLQKQEVKNLHQRLEGQRpENKGKNRYKNILPFDHSRVILQGRDSnipgsDYINANYIKNqlLGPDENAKTYIASQGCLEATVNDFWQMAWQE
..   .| |..  | .|.  ..  . ||| |||...|.| |  || |.         ||||| .|       ... | ||..|. |. || |||.| ..|
nnklfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr.....dyinavfipv..sksykqdkkyiiaqsPldrtvvdfWkmvfde

NSRVIVMTTREVEKGRNKCVPYWPEVGMQrAYGPYSVTNCGEHDTTEYKLRTLQVSPL--DNGDLIreIWHYQYLSWPDHGvPSEPGGVLSFLDQINQRQ
.   ||| |.  |  | ||  |||. | .  ||.. ||   |     .  . | .      .  |.  . |||.  | . | .  .   |  ....   |
kitaivmltklqedlrikCsqyWPkrGse.dyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleyg.eqaiinslvkfnkvislq

ESLPhAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAI
   .  |||.||||.|||||.. | .   .... |. .   .|. ......| || ..|||  |||... ..
tesk.kgPivvhCstgiGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 244-517 3.6e-50 165.7 In-house 22-280 (439) alignment 
Range on Protein: 244-517
Range on HMM: 22-280/439.0
FWEEFESLQKQEVK-NLHQRLEGQRpENKGKNRYKNILPFDHSRVILQGRdSNIPGSDYINANYIKNQLlgpdeNAKTYIASQGCLEATVNDFWQMAWQE
| |.||...  . . .    |  |   .. |||||.. .|||.||.||     .| | ||||||||        . | |||.||  . |..|||.. ...
fkeifekinstspdyaciaslaaqe.ydqtknrykdvgafdhtrvtlqei.pgvphshyinanyikGyy.....ddklyiatqgpkkettddfwrlviek

NSRVIVMTTREVEKGRnkcvpYWPEVGmQRAYGPYSVTNCGEHDTTEYKLRTLQVS-PLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQE
..  ||| |  ||  .     |||  . .  ||  .|    . .  .| .| ..|    |...  | . ...|..|||. ||..   || ||  ||  ..
ktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

SlPHAGPIIVHCSAGIGRTGTIIVIDMLMENIStkgLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
.    ||..||||||.||||||| .|. .|..    |.  .||.  ....| ||  |||. .|| ||| |. . | 
k.eeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
0049772 (Phosphotyrosine protein) phosphatases II 262-528 5.4e-50 166.2 In-house 38-292 (314) alignment 
Range on Protein: 262-528
Range on HMM: 38-292/314.0
RLEGQRPENKGKNRYKNILPFDhSRVILqgRDSNIPGSDYINANYIKNQllgpdenaKTYIASQGCLEATVNDF----------WQMA--WQENSRVIVM
.| .. ..|. ||||..|||.| .||||     .. |||||||.|...         ...||.|| || ||.||          |.|   .. |.|.|||
ilvadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf........lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

TTREVEK---------------------GrnkcvpywpevgmqraygpysvtnCGEHDTTEYKLRtlqvSPLDNGDLIREI-WHYQYLSWPDHGVPsEPG
. .|| .                     |                        .  .  .   |.    . |....|  .   .| .. .||...|  . 
srdevladelsrLdaAlgKtpllildgng........................neptaadlellk....eelydpelferlgikylripvpDgsap.lle

GVLSFLDQINQRqeslPHAGPIIVHCSAGIGRTGTIIVIDMLMENIstkgldcDIDIQKTIQMVRAQRS-----GMVQTEAQYKFIYVAIAQFIETTKKK
 ...||. |..     .  ||..|||.||.||||| .|...||          ..........||..|.     |....  || ||. |. ..... ||.
dfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf

LEVLQS
 |.|. 
yeylee
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 240-514 3.4e-49 162.3 In-house 18-234 (392) alignment 
Range on Protein: 240-514
Range on HMM: 18-234/392.0
AKAGFWEEFESLQKQEVknlHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMA
  | | |||  |   ..   ...  .|.. |. |||||||||.| .||.|.  | .|| |||.|| ||..      .| |.||||||   |...|||.| 
hsalffeefhdlpgpdi...ypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsf.....dnekayiasqgpnaaslddfwrmv

WQENSRVIVMTTREVEKGrnkcvpywpevgmqraygpysvtncgehdtteyklrtlqvspldNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQR
.|||   |.| |.  |                                              .||  | .  ...  |||..||     .| |. ...  
fqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

QESLPHagPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
  .  |  |.|.|||||.|||| .| || ..    .  .   .|. . .  .| .|  ||||. || ||| |. .
fGqyth..pliihcsagvgrtgvvisidsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 239-519 1.3e-48 160.2 In-house 12-296 (301) alignment 
Range on Protein: 239-519
Range on HMM: 12-296/301.0
TAKAGFWEEFESLQKQEVKNLHQrleGQRPENKGKNRYKNILPFDHSRVILQGRDS-NIPGSDYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQ
. . .| |....|...| |. .    | . |||  ||.||| ..|. |.||.   . ..   .||||.||..       ..| .||.|| .. |. |||.
khsnkfeeqykelkegedksctv...glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy.....sekkkfiaaqgpmkktlvdfWr

MAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLD---NGDLIR-----------EIWHYQYLSWPDHGV
. |||    ||| | . |. ..||  |||.  . .  .|| .||   |.   .. .| |.|   |   || ..|           ..  .|  .||..||
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

PSEPGGVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
  ||  ||  .|.. .|| . .  ||..||||....|.|. . ... .|     |    .|. . .. || .. |.|.|  || .|| .| ....  
vreprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 269-537 4.4e-48 158.9 In-house 40-299 (307) alignment 
Range on Protein: 269-537
Range on HMM: 40-299/307.0
ENKGKNRYKNILPFDHSRVILQGRDSnipGSDYINANYIknqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
 |  ||||...   |..|....        |||| |||.     |   . | .|..|| ||.|. .|| || ||.   ..|  . .| .. ||  ||| .
antdknryqdvkcqdkgrivvkfdgl...asdyihanyl.....giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

-GMQRAYGP----YSVTNCGEHDTT-EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslphagPIIVHCSAGIGRTGT
 | . ..|      ||.| | .  . . .|  .    .| ..  | | |.|.  |||.|||    . . .|. ..  ..      |..||||||.||.||
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn......pvvvhcsaGvGrsGt

IIVIDMLMENIsTKGLDCdIDIQKTIQMVRAQRSGMVQTEAQYKFIY-VAIAQFIETTKKKLEVLQSQKGQESEYG
|. | .... .  .| .|  |..| .. .|.||   .|||||| ... | .  |.|  |.  | |   |  | .| 
ivaislvqdkm.iaGinc.kdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekya
0036282 (Phosphotyrosine protein) phosphatases II 298-509 1.3e-45 150.5 In-house 1-163 (174) alignment 
Range on Protein: 298-509
Range on HMM: 1-163/174.0
GSDYINANYIKNQLLGPdenakTYIASQGCLEatvndFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEvgmqraygpysvtncgehdtteyklrtlqv
|||||||....     |      .||.||.|.     ||.| ........|| ..|.|.|. ||  ||||                              
gsdyinaspldlsyitp.....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................

splDNGDLIREIWHYQYLSWPDHGVPSEPGgVLSFLDQINQRQESlPHAGPIIVHCSAGIGRTGTIIVIDMLMENIStkglDCDIDIQKTIQMVRAQRSG
   .  || |....|.|| |||||||. .  .|.|...... ... .. ||..||||||.|||||........ ..        .|. ......| ||.|
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpg

MVQTEAQYKFIY
||||. ||.|.|
mvqtpsQyrfly
0043147 (Phosphotyrosine protein) phosphatases II 297-509 8.4e-45 147.9 In-house 3-154 (172) alignment 
Range on Protein: 297-509
Range on HMM: 3-154/172.0
PGSDYINANYIKNQLlgpdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREvekgrnkcvpywpevgmqraygpysvtncgehdtteyklrtlq
.|||||||.|..          . .|| ||.|  |..|||.| .... ..||. |..                                           
egsdyinasyldlyy.....ipdrfiatqgplrntladfwrmlkelgithivnltel...........................................

vsPLDNGDLIREIWHYQYLSWPDHGVPsEPGGVLSFLDQINQRQeSLPHAGPIIVHCSAGIGRTGTIIVIDMLMenistkgldCDIDIQKTIQMVRAQRS
   .|  .| |....|.||.|||||||  .  .|.||..|....  |   ||..||||||.|||||........         ...........||..|.
..lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRp

GMVQTEAQYKFIY
|.||.. ||.|.|
gavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 297-515 1.1e-43 144.3 In-house 10-172 (176) alignment 
Range on Protein: 297-515
Range on HMM: 10-172/176.0
PGSDYINANYIKNQLlgpdenaktYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEvgmQRAY-Gpysvtncgehdtteyklrtl
...||||||.|   .         .|| || |. |. ||..| .... ...|. | |||.|| ||  ||||    ...                      
ldldyinanlilgsr.........piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi....................

qvspldngdlireiwHYQYLSWPDHGVPSEpGGVLSFLDQINQRQESlphAGPIIVHCSAGIGRTGTIIVIDMLMEnistkglDCDIDIQKTIQMVRAQR
               .|..| |||||||.    .|..|..|......    ||..||||||||||||......|.        ............||.||
...............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqR

S-GMVQTEAQYKFIYVAIAQF
. |.|||..||.|.| .. ..
plgavqtpeQyrflyefelll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 271-513 5.6e-43 141.7 In-house 57-280 (290) alignment 
Range on Protein: 271-513
Range on HMM: 57-280/290.0
KGKNRYKNILPFDHSRVILQgrDSnIPGsDYINANYIKNQllgpdenAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV-G
  |||||..   | .||||.  |   .| ||. |||.|           ..| .|| |..|| |.|.|  ||.  .|||    .|.|. || .|.||  |
fkknrykdvvcndktrvilk..dG.ydG.dyvhanyvkGl.......kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

MQRAYGPYSVTnCGEHDTT--EYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQrqeslpHAGPIIVHCSAGIGRTGTIIVID
   ..| ..|. | |.|.   . ...|| |   |.|     . |..  ||||. |.     .|  |  . .       .||..||||||||||||.. |.
evltfGeitvl.cseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaie

MLMeNISTKGLdcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA
. . .| ..|   ..|. .... .|  | . || . ||  .  .. 
vgl.qilldGk..eldlldlvralrnsrlnsvqvdiqylalveill
subfamily_CG7180_pd Subfamily CG7180 264-518 1.5e-42 140.3 In-house 36-292 (296) alignment 
Range on Protein: 264-518
Range on HMM: 36-292/296.0
EGQRPENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINANYIKNQLlgpdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRnKCVP
 | | ||..|||. ...|.|. ||.|.  | .   |||||| |.   |       | ||  ..  . ||..||.. ..|..  .|. |.. .  . ..  
gglrkenreknrdvkvvPyDynRvvLekldGee.ksdYinavyvdsfl.....kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPEVGmQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL---------DNGDLIREIWHYQYLSWPD-HGVPSEPGGVLSFLDQINQRQESL---PHAGPII
|||. . .  ||.  |    |.  .. | ||...            .     | . ..|.  |.  . ||.   ... .. .... .|     |. ||..
ywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGIGRTGTIIVIDMLMENISTKGldcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIET
|..| | .|.|  . ||. .| .. ..    .|. . ....| .| ..|..  .||.||  . ... .
vvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 238-523 1.1e-41 137.5 In-house 18-293 (305) alignment 
Range on Protein: 238-523
Range on HMM: 18-293/305.0
DTAKAGFWEEFESLQKQEvkNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGrdsNIPgSDYINANYIKNqllgPdENAKTYIASQGCLEATVNDFWQ
. . ||. .|| .... .  ....    .  ...||||||..  .|. || |.|     |  .|| |||.      |  |.| .| .|  || |  ||| 
ekgpaglraefvamkrfn..dfekmkafkeaqeagknrykdvgcldnnrvkleg...pwp.heyihanyvst....p.tnpkrfictqaplektcadfwy

MAWQENSRVIVMTTREVEKGRNKCVPYWPEVG---MQRAYGPYSVT-------NCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPG
| .|..   | |    .||| .||. |..      ..   .   ..       .   .. .. |..  ..     |   | . || .  ||| |||.   
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl

GVLSFLDQInqRqeslPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkGLDCDiDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETtKKKL
 .| .| .   |    |  |||.|||||||||||...... ..... . |   . | .| .| .| ||   .||.||| |..  | ....  || |
ailelleka..r....pskgpivvhcsagigrtgsvvmleyildqlla.gqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk.kkll
subfamily_ptpA1_pd Subfamily ptpA1 260-473 1.6e-41 137.4 In-house 37-256 (418) alignment 
Range on Protein: 260-473
Range on HMM: 37-256/418.0
HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDsNIPGSDYINANYIKNQllgpdeNAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN
 .  ||..  |  |||| |||| .|.|| |.  . .  ||||||||||           | .|..|| |  |. |||.| |..  |.||| .|| |. | 
setsegdkkhntsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidga......ypkqfictqgplpntiadfwrmvwenrcriivmlsresencri

KCVPYWPEV-G-M--------QRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL-P---H
||  ||||  |          .  .| |||      .  | .. | ..    .|.  |.| .|||  |||| .|     .  .|  | .||. . |   .
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

AGPIIVHCSAGIGRTGTIIVIDMLMENI
  |||||||||.|||||.    ..|...
nvpiivhcsagvgrtgtfctavimmkkl
0049260 (Phosphotyrosine protein) phosphatases II 319-509 2e-41 136.5 In-house 9-143 (152) alignment 
Range on Protein: 319-509
Range on HMM: 9-143/152.0
KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWpevgmqraygpysvtncgehdtteyklrtlqvspldngdlireiwHYQYLSWP
. .|| ||... |..|||.| .. . ..||| |...|.|. ||  |.                                             .|..| ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwp

DHGVPSEPGGVLSFLDQINQRqeSLPHAGPIIVHCSAGIGRTGTIIVIDMLMenistkgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIY
|||||. .  .| .|. |...   |   ||..||||||.|||||........         ...........||..|.|.|... |..|.|
Dhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 270-520 6.5e-39 128.3 In-house 52-294 (310) alignment 
Range on Protein: 270-520
Range on HMM: 52-294/310.0
NKGKNRYKNILPFDHSRVILQGRDSNIpgSDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVG
.  |||| ...  | ||| |.   |     ||| |||.| . |      .|.| ||| |. |. |||.| .|| .  |..  . .|.|| ||| ||| .|
ymhknrysdvvcldtsrvklkidksry..edyihanyvktnyl.....rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg

MQRAYGPYSVTNCGEHdTTEYKLRTLQVS------PLDNGDL-IRE--IWHYQYLSWPDHGVPSEPGgvlsflDQINQRQESLPHAGPIIVHCSAGIGRT
.  .||   ||| .|  . |...  | |.      |.|.    ..|  .   ..  ||| ||| |          . ||  .    || .||||||..|.
vtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrllaqvrhgpcvvhcsagkdrl

GTIIVIDMLMENiSTKGLDcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTK
.... ... ... . .||   .|... .  .. .|   .||| || .|      |  . .
yvvvalklkidk.ldrglk..vdaeevktellksraiciqtelqyliidrvriifarget
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 246-526 7.5e-39 128.2 In-house 28-300 (305) alignment 
Range on Protein: 246-526
Range on HMM: 28-300/305.0
EEFESLQKQEVKNLHQRLE--GQRPE-NKGKNRYKNILPFDHSRVILQgRDSnipGSDYINANYIKNQLLgPDenaKTYIASQGCLEATVNDFWQMAWQE
||| .| |    .. | .    | .. .. ||||...   |.| | |. . |    |||| |||.   .. |.   | .|..|| |. |...|| |  |.
eefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkld.kps...psdyihanyvgcpmi.pe...krficaqgpldqtidefwwmviqn

NSRVIVMTTREVEKGRNKCVPYWPEV-GMQR-AYGPYSVTNCGEHD----TTEYKLRTLQVSPldNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQI
.   |||  . || |. ||  |||   | ..   .   | |          .| .. .|...   .||    . | |.  ||| |||      | .|  |
kveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlty..sgdqkmsvrhlqwtewpdrgvppckltslellsai

NQRQeslphaGPIIVHCSAGIGRTGTIIVIDMLMENISTKgLDCDiDIQKTIQMVRAQRSGMVQTEAQYKFIY-VAIAQFIETTKKKLEVL
   .       ||.|||||||||||||. |. ..|.|. .  .|   . . .. .| ||.  .|.. || ||. | .  |.|  |.|   |
rgsk......vpivvhcsagigrtgtivaieyilekiaen.kpcp.pmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 244-521 5.9e-38 125.1 In-house 13-274 (281) alignment 
Range on Protein: 244-521
Range on HMM: 13-274/281.0
FWEEFESLQKQEVKNLHQRLegQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQEN
| .||  |  .   .|   .  ..| |. |||| ||  .| ||| |. .  |   .||| ||||.  .|      . || .||  . |  |||.| ||||
fkqefsnlpgdppsdlctvf..nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.....krgyiltqgpkketradfwrmiwqen

SRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNcgEHDTTEYKLRTLQVSPLDNGDlIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRqes
.  |||  . .|  |.||  |.|        .  .||.   |  | .  | | ..    .|.  | | |. .  |||  ||     .|  | .|  |   
ttaivmlcqfletnrekcaeyfprnahcclqfdklsvsy..edstvnkslvttrlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirar...

lphAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIdiQKTIQMVR-AQRSGMVQTEAQYKFIYVAIAQFIETTKK
   . | ..|||||.||.||.. ... .. | ..    ||  .. .  .| . |.  |||  || .|.  . .|  . |.
...stppvihcsagvgrsgtlmaveialqsihshftlpdi..kqivshlrvtgraasvqtlqqymliwkvlldfgvaykq
0044763 (Phosphotyrosine protein) phosphatases II 281-511 1.6e-37 124.2 In-house 1-166 (178) alignment 
Range on Protein: 281-511
Range on HMM: 1-166/178.0
PFDHSRVILQGRdSNIPGSDYINANYIKNQllgpdenakTYIASQGCleatvNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMqraygpysvt
|.|..||.|. . .....||||||..| .           |..|...      |.... .... ..||. | |.| |..|| |||||             
pldrtrvllsnl.eglersdyinaseilpg.........lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........

ncgehdtteyklrtlqvspldngdlireiWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslPHAGPIIVHCSAGIGRTGTIIVIDMLMENistkgldc
                             ..|... .||||||. .  .| |.. |.. ..  .. ||..||||||.||.||..........        
.............................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl........

DIDIQKTIQMVRAQRSgMVQTEAQYKFIYVA
...... |..||..|. .|... |....|  
glsleeaielvrerRp.ivpnpgqlrqLyef
PTPc_DSPc_SM00012 409-513 1.5e-36 120.1 In-house 2-104 (105) alignment 
Range on Protein: 409-513
Range on HMM: 2-104/105.0
IWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldCDIDIQKTIQMVRAQRSGMVQTEAQYKFI
. ||.|..|||||||.|.  .|..|..... ..   ...|..||||||.|||||....|.|.......     .||.......| ||.||||||.|| |.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YVAIA
| |..
yrall
0051082 (Phosphotyrosine protein) phosphatases II 298-512 1.7e-36 120.4 In-house 2-149 (151) alignment 
Range on Protein: 298-512
Range on HMM: 2-149/151.0
GSDYINANYIKNQllgpdenaktYIASQGCLEatvnDFWQMAWQENSRVIVMTTREVEKGrnKCVPYWPEVGmqraygpysvtncgehdtteyklrtlqv
 |||||..|. .           ...|.| |.    ||... .... ..||. . |.| |  .|  |.|| |                            
lsdyinfsyvtgg..........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg............................

spldngdliREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQrqeslPHAGPIIVHCSAGIGRTGTIIVIDMLMENistkgldcdIDIQKTIQMVRAQRSG
         .|..|...|.|||.|.|  .  ||.||.....     .  ||..||||||.|||||..........         ..........|..| |
.........ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpg

MVQTEAQYKFIYVAI
.||.. |. |.. |.
vvqpnqqflfqlfal
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 241-522 6.3e-33 108.9 In-house 5-265 (267) alignment 
Range on Protein: 241-522
Range on HMM: 5-265/267.0
KAGFWEEFESLQKqeVKNLHQRLEGQ-RPENKGKNRYKNILPFDHSRVILQGRDSNipgsdYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMA
.  . .||| ..|  . . ....      .|. .||. . ||.|..||||. .. .     |||| |..       .  ...|. |. |. |. ||... 
eceiekefelikk..isdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegy.....ktknafivtqdplkntitdfltvi

WQENSRVIVMTTREVEKGRNKCVPywPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSpLDNgDLIREIWHYQYLSWPdhgVPSEPGGVLSFLDQINQR
 ...  |||. |.  .   ..  |  |..|  . |   .|  . |..  .|.. ||..  . | .  ...  | |  |    . ..    |  |  |  .
hdqkvpvivlltkvftdnirlfwP..Pkmgqakkyqdltvehslekeendyqiitlelk.fkn.esahnvtlyyykkwn...intnnkpylkplfgilak

QESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKK
..      |..|.||.|.||.|| .|||  .| . | |     || . .. .| || |.|.|  .| .|.  .|.. |   |.
nqlengnrPlvvacsdGvGrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaeyaegrlke
subfamily_CG42327_pd Subfamily CG42327 259-439 7.5e-33 108.5 In-house 17-193 (319) alignment 
Range on Protein: 259-439
Range on HMM: 17-193/319.0
LHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNiPGSDYINANYIKnqllGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGR
|  | .   .  | |.|. |..|. ..||.||   .. . . |..|.|..    |.|.    |||.|  || .  |||.. |. .|||||  |   |.| 
liaradevPvtskdksrvinvvPlPetrvvlqrigdd.dkdeyldasyvr....GyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGi

NKCVPYWPEV---GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDnGDLIREIWHYQYlSWPDHGVPSEPGGVLSFLDQINQR
..|  |.|       ...|| . ||  |     .| . || .  .| ... ||. || |  |.. .||.|.  ... | .... 
kvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 269-516 1.8e-30 101.0 In-house 42-271 (288) alignment 
Range on Protein: 269-516
Range on HMM: 42-271/288.0
ENKGKNRYKNILPFDHSRVILQgrdsnipgsDYiNANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV
.|  ..||.|.   | .|| |.         |     ||. ...   .. .  | .|  |..|.. .|.|  ... . ||| .. .|||..|   |.| .
anptrdryenlprcditrvkls.........dd.pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

GMQR-AYGPYsVTNCGEHDttEYKLRTLQVSPLDNGDLIREIW---HYQYLSWPDHGVPSEPGGVLSFLDQInqrqESLPHagPIIVHCSAGIGRTGTII
  ..  .| .  |   ..   .   ....|| | .   . |     .  .| |.|.||| .    | .|. .    .|| .  ||.||.|||.|||||.|
lGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqk..PivvhssaGvGrtgtli

VIDMLMENIStkgLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.| . .| .    || .. |.. ..  |..|   .||| || ...  . . .
lilialeslr...lddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 271-510 1.2e-29 98.1 In-house 51-275 (301) alignment 
Range on Protein: 271-510
Range on HMM: 51-275/301.0
KGKNRYKNIlPF---DHSRVILQGRdsNIPgsdyINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE
| |.||... |       .|| .|.   .|    | ||.|. .      ... .||.|| |..| .||| |  | .   ||| ...|||  .||  | | 
kdkhryptv.PckPstavevivdGk..rvP....ihanwipts.....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

V-GMQRAYGPYSVTNCGEHDTTE--YKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslphagPIIVHCSAGIGRTGTII
  . .   | ....   ..   .   . |||.|    .    | . |||| .|.|.|||     .  ... . . ..      ||.|||||||||. . |
kisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafi

VIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYV
  ..|  .. .   |  |....... .| .|   |||. |  .. .
gteylarevea...dptieltealkhlrehrwngvqtnsqlywmtl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 270-515 1.3e-29 98.1 In-house 35-269 (285) alignment 
Range on Protein: 270-515
Range on HMM: 35-269/285.0
NKGKNRYKNILPFDHSRVILQGRDsnipgSDYINANYIKNqllgPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPE-V
|   ||| ..   . .||.|. .|      ||| |....     | ..  |||..|| |  |..|||.| .||.   ..|    .| | .||  |.|| .
npdlnryadvrcieetrvvlknhd.....rdyihaswmrm....pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

GMQRAYGPYSV--TNCGEHDTTEYKLRTLQVSPLDN-GDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINqrqESLPHAGPIIVHCSAGIGRTGTIIV
|    .| | .  |.| |   .   | .| |   ..       . | |   |||.  | .   .. .   ..   .  |.  || ||||||.||| |.. 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk...kvnpkekpicvhcsagvgrtatfvg

IDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
||     |     . .|..   .. .|| |   ||.  |. |.|| . ..
idyatirime...npniemldivremramrfqavqshmqflflyvvlmey
0048076 (Phosphotyrosine protein) phosphatases II 372-513 1.9e-29 97.6 In-house 26-140 (145) alignment 
Range on Protein: 372-513
Range on HMM: 26-140/145.0
RAYGPYSVTNCgehdtteyklrtlqvsPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESlphAGPIIVHCSAGIGRTGTIIVIDMLME
. .| . | |.                  .  .| |....|.||.|||||||. .  .|.||..|.. ...    ||..||||||.|||||.........
kdlgittvlnl................tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll

nistkgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIA
        ...........||.||.|.|... |..|.| .. 
........lgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 372-510 1.1e-28 95.1 In-house 26-139 (144) alignment 
Range on Protein: 372-510
Range on HMM: 26-139/144.0
RAYGPYSVTNCGEHDTTEYKLRTlqvspldngdlireIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslpHAGPIIVHCSAGIGRTGTIIVIDMLMe
...| . | |. |.   |.  |.              ...|..|.|||||||. .  .|.||. |.. .|   . ||..||||||.|||||........ 
kklgittvinlteeyepeflere..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.

nistkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYV
        ...........||..|.|.|... |..|.. 
.......klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 271-371 1.2e-28 94.9 In-house 48-156 (350) alignment 
Range on Protein: 271-371
Range on HMM: 48-156/350.0
KGKNRYKNILPFDHSRVILQ-------GRDSNIPGSDYINANYIKNQLLGPDENAKT-YIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCV
  |||||||||..||||.|.       ...  . ..|||||||.| .  . . |..  ||| |. |  ||.||...  . . .||.. | .|| ...|| 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

PYWPEVGMQ
 ||.| ...
rYWqegsyd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 271-519 5.2e-28 92.6 In-house 44-279 (312) alignment 
Range on Protein: 271-519
Range on HMM: 44-279/312.0
KGKNRYKNILPFDHSRVILQGrDSNIpgsdYINANYIKNQllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV--
|  ||| ||  .|  |  | | | |.    || ||..|        . . ....|| || |.  |||.|    |  |.. .  || | .||. |  ..  
kdlnrypniqcwdrgrftlag.denf....yihanfvkic.....tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

----GMQRAYGPYSV-TNCGEHDTTEYKLRTLQVSPLDNGDLiREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQEslphagPIIVHCSAGIGRTGTI
      .| |  |    . | .       | |.|     |.    . |||. ||||||.|      | .|  ... .       |.| |||||.|||||.
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtl

IVIDMLMENISTkglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETT
..|. ..  .         .....  ..| .|.  |.. .|| .   .. .|. . 
aliesmiaalrh...prkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_egg_pd Subfamily egg 269-517 1.4e-26 87.9 In-house 39-271 (307) alignment 
Range on Protein: 269-517
Range on HMM: 39-271/307.0
ENKGKNRYKNILPFDHSRVILQGRDSNIPGsDYINANYIKNQLLgpdenAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKgrNKCVPYWPEV
.|. | | | .   | ||| |. |     . |.| ||..| . |       ..| .|  |  ||.|||.| .||. . ||| |  .|   ..|  |||  
nnlekarskrvhckdssrvklelrrGqyld.dfihanrvkGkpl.....lnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

GMQRA---YGPYSVTNCGEHDTTE--YKLRTLQVSPLDngDLIREIWHYQYlSWPDHGVPSEPGGVLSFLdqinqRQESLphagPIIVHCSAGIGRTGTI
  . .    | . ..| . .....  ...  |..   |  |  | . |.|.  .   .    |  ||  |     |. |     |..|..  |. ...|.
esdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dvnnssdvysplrvlrkl.....rnlsk....pvvvqdilGvskaatl

IVIDMLMENIsTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
. |.. . ..  .|      ........| .|   |..  .| |.|  .. |. 
vaieiallsl.lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
SH2 SH2 domain 110-194 1.2e-24 76.8 Pfam-A 1-77 (77) alignment 
Range on Protein: 110-194
Range on HMM: 1-77/77.0
WYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQpkagpgsplRVTHIKVMCEGGR-YTVGGLETFDSLTDLVEHF
||||..|. .|| ||.......||||||| |.|||..|||. |.         .|.|......  . |.. . |.|.||..||||.
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.........kvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 273-529 5e-24 79.9 In-house 22-272 (290) alignment 
Range on Protein: 273-529
Range on HMM: 22-272/290.0
KNRYKNILpFDHSRVILQGRDSNIpGSDYINANYIKNqllgPdeNAKTYIASQ-------GCLEATVNDFWQMAWQENSRVIVMTTREVEKGRN----KC
..|... | . ..||.|.|  . .  .||| ||...     |  |    |..|          ..|...|| || ||... .||.    || .|     |
dqRlevpL.veatrvvLkgygkrf.nddyiHAnrvtc....p..nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaC

VPYWPE-VGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLirEIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQeslphaGPIIVHCSAGIGRT
  | || || .  ..  .|  .      . . |.| |   |. ..   . |... .| .  |. ..  .|| ........       |.||||  || | 
akYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeef..tvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrs

GTIIVIDMLMENISTKglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ
 ..  |.. .  |  .    .. ... ....| ||  ..... .. |.  .|   .  .... .  ...
AalaaiilgyQkiaet..sgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete
SH2 SH2 domain 4-79 2.2e-23 72.7 Pfam-A 1-77 (77) alignment 
Range on Protein: 4-79
Range on HMM: 1-77/77.0
WFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF-YDLYGGEKFATLTELVEYY
|.|...|. .|| ||. .. .|.|| |.|....||..|||.  ..|.|.|||.. .  | . ..||| .|.||||.|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 318-509 1.8e-21 71.2 In-house 4-197 (199) alignment 
Range on Protein: 318-509
Range on HMM: 4-197/199.0
AKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKLRTLQVSPL-DNGDLIREIWHYQYL
 . |||.|  |  |. ||||| |.  |  |||   .  .       ||| .      ||  |||        .| . .| ..         ||| |||. 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPSEPG--GVLSFLDQINQRQESLpHAGPIIVHCSAGIGRTGTIIVIDMLMENIStKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIY
|| ..  |      | .    .. .. |   .  |.||||| | | || .. .|. .     .     .|. .  . .|  | |.. .  .|.|||
swkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrshe.esktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 319-509 2e-21 71.1 In-house 4-196 (198) alignment 
Range on Protein: 319-509
Range on HMM: 4-196/198.0
KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM-QRAYGPYSVTNCGEHDTTEYKLRTLQVSPL-DNGDLIREIWHYQYLS
. |||.|  |  |. ||||| |.  |  |||   .  .       ||| .      ||  |||        .| . .| ..         ||| |||. |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPSEPG--GVLSFLDQINQRQESLpHAGPIIVHCSAGIGRTGTIIVIDMLMENIStKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIY
| ..  |      | .    .. .. |   .  |.||||| | | || .. .|. .     .     .|. .  . .|  | |.. .  .|.|||
wkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrshe.esktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 407-514 1e-20 68.5 In-house 89-192 (440) alignment 
Range on Protein: 407-514
Range on HMM: 89-192/440.0
REIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLpHAGPIIVHCSAGIGRTGTIIVIDMLMENISTkgLDcDIDIQKTIQMVRAQRSGMVQTEAQYK
| . .|.| .|||.|||   | || .....|. ||     ||..|||||| |||| ||..| .. .      | .|||   |. .| .|  ||||  || 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakr..sd.qidifsfinsmrnnrpqmvqtpeqya

FIYVAIAQ
|.. |. .
fvheavle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 323-516 2e-20 67.9 In-house 39-221 (255) alignment 
Range on Protein: 323-516
Range on HMM: 39-221/255.0
AsqgcleaTVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVgMQRAYGPYSVTNCGEHDTTEYKLRTLQV-SPLDNGDLIREIWHYQYLSWPDHG
        ||. |.|.  | .. |.|| .   |.|..||  |.|    .       |. .  . ...  ||||.. | | .    ... ||.|  |... 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple.kdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPSEPGGVLSFLDQINQRQeslphagPIIVHCSAGIGRTGTIIVIDMLME----NISTKgLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
 | ..  .|  |  . . .       ...||||.||||. . ......      .. |     ..|  . .. .| .|.. ..|  |  |  . . ...
aPelareilnilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldtt.etveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 330-515 4.5e-20 66.3 In-house 102-287 (302) alignment 
Range on Protein: 330-515
Range on HMM: 102-287/302.0
ATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWP-EVGMQRAYGPYSVTNCGE-------HDTTEYKLRTLQVSPLDNG-DLIREIWHYQYLSWPDH
 |.. .| .  | |  ..|  .  ||.. .|| .|.  .|| .  .| |.|.            |  ..|| |...       .. . .   .. .||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPSEPGGVLSFLDQInqrqESLPHAgpIIVHCSAGIGRTGTIIVIDMLMENISTKGLDcdiDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
| | |.   |  |       ||  ..  ..||||||.|||||.. |   ..  |.|      |. . .. ||. | | ||.| |  .. . ... 
Gapkeaytaldilkfc....esykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 269-517 1.6e-19 64.6 In-house 46-280 (303) alignment 
Range on Protein: 269-517
Range on HMM: 46-280/303.0
ENKGKNRYKNILPFDHSRVILQgrDsnipgSDYINANYIKNqllgpdENAKTYIASQGCLEATVNDFWQMAWQENSRV--IVMTTREVEKGRNKCVpyWP
.|  |||. ... .|||.| |   |     | || |.|..       .  |  | .|  |  |  |||||  ... ..  ...|  | .|   . |  .|
knmdknrfvdvicldhskvkls..d.....ssyihasylel......dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv..fp

EVGMQRAYGPYSVtNCGEHDTTEY-KLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEpgGVLSFLDQINQRQESLP---HAGPIIVHCSAGIGRTGT
.      .   |.   ||    |  .  .|.|  . |||    .  ..| .||   .||.  |   |. || | |  |    .. | .    .| ||.||
rnqdflkfeersi.rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsd..gspkfvkqiwqlqsvlrkysdstptvymslsgcgragt

IIVIDMlmENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
. ...     .| .  .  .|. | ...||  |   ||  .|. ..|  .|. . 
falfet..ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_CG42327_pd Subfamily CG42327 437-515 5.7e-18 59.6 In-house 238-314 (319) alignment 
Range on Protein: 437-515
Range on HMM: 238-314/319.0
NQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKglDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
. |     . ||..|||| |.||||..|  |. .... .      .|| .... || .|.  |.|  ||.|||  . ..
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 408-516 9.8e-18 59.0 In-house 216-344 (350) alignment 
Range on Protein: 408-516
Range on HMM: 216-344/350.0
EIWHYQYLSWPDHGVPSEPGGVLSFLD-------QINQRQES-LPHAGPIIVHCSAGIGRTGTIIVIDMLME------NISTKGLDCDI------DIQKT
.... |.  |.| ..  .|  .|. |.       . . .. .   .. ||.||||||.|||||.. .|.|..      |.  .    |        |. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.. .| ||  |||.  |. ||| |.  . 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 271-368 1.2e-16 55.0 In-house 49-156 (349) alignment 
Range on Protein: 271-368
Range on HMM: 49-156/349.0
KGKNRYKNILPFDHSRVILQGR--------------DSNIPgSDYINANYIKNQLLGPDEnakTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK
  |||||.|||..||||.|.                || ..  |||||||.|   . ...    ||| |  | .||.||...   .. ....  . . |.
faknrykdilPyehsrvklkkslksskvikastsesdsgkl.ddyinanylkltrisvek...kyiatqaPlPstvddfykvillngvklvlsLnddkel

GRNKCVPYWPEV
. .||  || | 
slekcdiywqel
subfamily_hpo-7_pd Subfamily hpo-7 323-524 3e-16 54.1 In-house 42-235 (263) alignment 
Range on Protein: 323-524
Range on HMM: 42-235/263.0
AsqgcLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEV-GMQRAYgpYSVTNCGEHDTTEYKLRTLQVSP-LDNGDLIREIWHYQYLSWPDH
     |  |.. |.|.  | .. |.|| .   |.|..||  |.|     .. .    |. |  .   .  |.||..   |..   .... ||.|  |...
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl..anvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

GVPSEPGGVLSFLDQINQRqESlphagpIIVHCSAGIGRTGTIIVIDMLME----NISTKGlDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
  | ..  .|  |.   .   |      ..||||.||||.    |....      .. |     ..|  . .. .| .|.. ..|  |  |  . . .|.
ndpelareilnilkvarns.ks......lvvhcstGiGrsaafsvaElvyqkmirsldtts.tveldylsLleelrssrkraihtPmqLafsilmvLdfv

ETTKKKLE
     | |
lnnfakge
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 269-525 4.3e-16 53.2 In-house 50-294 (302) alignment 
Range on Protein: 269-525
Range on HMM: 50-294/302.0
ENKGKNRYKNILPFDHSRVILQGRDsnipgSDYINANYIKNqllgPDENAKTYIASQGCLEAT--VNDFWQMAWQENSRVIVMTTREVEKGRnKCVPYWP
.|  ||. ...   |. .|.|...       .|.||  ..     |. . ....|    .. .  |..||.|..||.   .|.  .| |  .     ..|
knlkknqsedvpildsnlvkleaep.....dsyvnaskvev....PeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfp

-EVGMQRAYGPYSVTNCGEHDTTEYK-LRTLQVSPLDNGD-LIREIWHYQYlsWPDHGVPSEPGGVLSFLDQInqRQESLPHAGPIIVHCSAGIGRTGTI
 . |    ||   | |     . | |   .. | | .  . .. .. . ..  |... || . . .     ..   ... .   ....    |.|| |..
kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagaf

IVIDMLMENISTKgldCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEV
..  . .|.. ..    .  |. ... .|.||. .|..  || ..|.|.. .| .  .| |.
ltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpee
subfamily_eak_pd Subfamily eak 258-423 7.6e-14 45.8 In-house 40-195 (332) alignment 
Range on Protein: 258-423
Range on HMM: 40-195/332.0
NLHQRLEGQRPENKGKNrYKNILPFDHSRVILQGRDSNIPGsdYINANYIKNQLLGpdenaKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG
.|    |..| |.  .|   .|.|.|.  | |     |  |  ||||  ..   .|     . || .    |  |  ||||  ...|  ||.   .||..
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinaslaefsevG.....rkyiltGiasedkvfafwqmvleqkspaivqlledvelk

RNKCVPYWPEVG-MQRAYGPYSVTNCGEHDTTEYKLRTLQVSpldNGDLIREIWHYQYLSWPDHGVP
 .|   |.|. .  .  .| . |.         .. | |..|    |.   .. ||..  | .  .|
leksdkyfpdktreelkfGildverkefvkrniletrllels...kGnethrvlhykvfGwtettlp
0038934 (Phosphotyrosine protein) phosphatases II 405-513 7.9e-14 47.2 In-house 75-174 (194) alignment 
Range on Protein: 405-513
Range on HMM: 75-174/194.0
LIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHaGPIIVHCSAGIGRTGTIIVIDMLMEnistkgldCDIDIQKTIQMVRAQRSGMVQTEAQ
. .   .|  | .||.|..     .|.||| ...  .  |. | . ||| ||.|||||...  ...         .... .. |...|  | |....  .
fekagieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdy

YKFIYVAIA
.. ...   
leallkryk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 450-514 2.1e-11 38.0 In-house 2-63 (69) alignment 
Range on Protein: 450-514
Range on HMM: 2-63/69.0
IVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQ
.||||.| |||||.| | . |  | .. |   .||   .| .|  |  ||  | .| ||. |...
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 450-516 2.2e-11 38.0 In-house 1-64 (69) alignment 
Range on Protein: 450-516
Range on HMM: 1-64/69.0
IVHCSAGIGRTGTIIVIDMLMENISTKGLdcdIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFI
.||||.| ||||| | | . |  | .. |   .||   .| .|  |  ||  | .| ||. |... .
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 409-517 2.6e-11 37.5 In-house 220-345 (349) alignment 
Range on Protein: 409-517
Range on HMM: 220-345/349.0
IWHYQYLSWPDHGVPSEPGGVLSFL-------DQINQRQ-ESLPHAGPIIVHCSAGIGRTGTIIVIDMLME----------NISTKGLDCDIdIQKTIQM
..  |.  |.| ..  .|  .|  |       |. . |.     .  ...|||||| ||||... .|.|..           |  . |  |. |. ..  
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDl.isiivne

VRAQRSGMVQTEAQYKFIYVAIAQFIE
.| ||  |||  ||. .|| |. ... 
lrkqrismvqnlaqfiaiyealLkyfa
subfamily_PTPDC1_pd Subfamily PTPDC1 407-509 4.9e-11 37.4 In-house 81-169 (182) alignment 
Range on Protein: 407-509
Range on HMM: 81-169/182.0
REIWHYQYlSWPDHGVPSepggVLSFLDQINQRQESLPHAgPIIVHCSAGIGRTGTIIVIDMLMENistkgldcDIDIQKTIQMVRAQRSGMVQTEAQYK
..| .|.. .|.|.||.|    . . || .   . .| .   . ||| || |||| .|   ..  .        ... .|.|..||..|.  .||  | .
qgiyvynf.gwkDygvas....leriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyak........rltaekaiklvrskrpksiqtreqve

FIY
.. 
lvk
subfamily_eak_pd Subfamily eak 443-528 3.5e-10 33.8 In-house 234-317 (332) alignment 
Range on Protein: 443-528
Range on HMM: 234-317/332.0
LPHAGPIIvHCSAGIGRTGTIIVIDMLMENISTKGLDcDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS
 |   |||  .. |  |.|. .|||.|.. |  |  .    ... |  |. .|   | .. |. ||| .. ... . ...|. |. 
ppsfapii.qsarGsaraGvfvvidllirlidnkkkn.lysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkk
PTEN_1 412-507 9e-10 33.7 In-house 97-184 (196) alignment 
Range on Protein: 412-507
Range on HMM: 97-184/196.0
YQYLSWPDHGVPSePGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIdMLMEnisTKGldcdIDIQKTIQMVRAQR-SGMVQTEAQYKF
|  ....|||.||    .. ..... .   |.|. . ..||| ||.||.||..    ||.   ...     . ......||..|  |....  | ..
ylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmy...kgk....ltadeAlelvrekRppgapnspsqerl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 266-309 1.3e-09 32.0 In-house 35-76 (244) alignment 
Range on Protein: 266-309
Range on HMM: 35-76/244.0
QRPENKGKNRYKNILPFDHSRVILQGrdSNIPGSDYINANYIKN
    |  |||| ||||||..||||    |.  ||||||||||. 
vlsanatknryinilpfdetrvilss..skkegsdyinanyiqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 266-308 1.4e-09 31.8 In-house 43-84 (440) alignment 
Range on Protein: 266-308
Range on HMM: 43-84/440.0
QRPENKGKNRYKNILPFDHSRVILQGRdSNIPGSDYINANYIK
  |.|| ||||.||| .|||||.|.     .| |||||| ||.
slpnnkvknryrnilaydhsrvmleev.kgvpdsdyinasyin
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 319-398 3.4e-08 27.3 In-house 236-312 (440) alignment 
Range on Protein: 319-398
Range on HMM: 236-312/440.0
KTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKgrnKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVS
...||.|  |..|| |||..  . .   |.|  .  .|    |  |||      ..||..|   |  .    |.|||.. 
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 328-517 7.3e-08 25.4 In-house 127-310 (346) alignment 
Range on Protein: 328-517
Range on HMM: 127-310/346.0
LEATVNDFWQMAWQENSRVIVMTTREvEKGRNKCVP-YWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLI-REIWHyqYLSWPDHGVPSE
 |. |.||| | .||. ... .   . .| .|     .  | |  .  |   . |     . . |  |..| |  | | .  .. |  .  |     |  
nesfvedfwymiyqeqihlvylmvpd.dklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhh..hapwkhlqqppk

PGGVLSFLDQINQRQeSLPHAGPIIVhCSAGIGRTGTIIVIDMLMENIsTKGLDCDIdiQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIE
   .. .. |.   .  .  ||  .|    | ||. ..|     ....   |.. .|   . .. .. || | |.. |||  ||  . ..| 
tlpiikmihqflsek.qvqnagvcvv.slfgcgracsfigalyainql.nngiepni..ceimknikqqrpggvesfaqyasiyaivfdyia
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 270-343 7.6e-08 26.2 In-house 37-109 (347) alignment 
Range on Protein: 270-343
Range on HMM: 37-109/347.0
NKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINaNYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQEN
.  ||| |.    | .||.|   .|.   .| .. .||.   .  |.  | || .|  |  || |||.|    .
slsknrskdvklidatrvvlspeksknsraddve.tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk
subfamily_CDC14_pd Subfamily CDC14 446-509 5.1e-07 23.9 In-house 263-317 (328) alignment 
Range on Protein: 446-509
Range on HMM: 263-317/328.0
AGPIIVHCSAGIGRTGTIIVIDMLMENistkgldcDIDIQKTIQMVRAQRSGMVQTEaQYKFIY
 | |.||| ||.|||||.|   .. .          .  . .|  .|  | |.| .  | ||..
eGaiavhCkaGLGrtGtLiacylmkhy........rftaaeaiawlricrPGsvigp.qqkfle
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 269-403 1.7e-06 21.0 In-house 26-119 (169) alignment 
Range on Protein: 269-403
Range on HMM: 26-119/169.0
ENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINAnyiknqllgpdenaktyiasqgcleatvndfwQMAWQENSRVIVMTTREVEKGrNkcvpYWPEv
 |. |||    |   | || ||    .. |||||||                                .| |. |. |||.     .|  |    .||| 
cnetknrpagplapshtrvklqrvmedl.gsdyina................................rmiwetnasvivvlgdtddkn.n....fwpe.

gmQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNG
  .  |  .     ||  |    .|| .| .. .|
..kedyqlhpavilgewytdslyvrtdkvhantsg
PTPc_motif_SM00404 439-501 2.1e-06 22.7 In-house 76-126 (140) alignment 
Range on Protein: 439-501
Range on HMM: 76-126/140.0
RqesLPHAGPIIVHCSAGIGRTGTIIVIDMLMENistkgldcDIDIQKTIQMVRAQRsGMVQT
        | ..||| ||. |..|.|.  .....         ..... ...|. .|  ... 
a...ekkggkvlVHCqaGvSRSatliiaYlmryr........qlslaeayefvkerR.piisp
DSPc Dual specificity phosphatase, catalytic domain 445-503 2.5e-06 22.4 Pfam-A 72-122 (133) alignment 
Range on Protein: 445-503
Range on HMM: 72-122/133.0
HAGPIIVHCSAGIGRTGTIIVIdMLMEnisTKGLdcdiDIQKTIQMVRAQRSGMVQTEA
  . ..||| ||| |..|.|.   ||.   ||.|    .... ...|. .|| ..... 
kgkkvlVHCqaGisRSatliia.Ylmk...tknl....slneAyefvkerrskispnag
DSPc Dual specificity phosphatase, catalytic domain 445-503 2.5e-06 22.4 In-house 72-122 (133) alignment 
Range on Protein: 445-503
Range on HMM: 72-122/133.0
HAGPIIVHCSAGIGRTGTIIVIdMLMEnisTKGLdcdiDIQKTIQMVRAQRSGMVQTEA
  . ..||| ||| |..|.|.   ||.   ||.|    .... ...|. .|| ..... 
kgkkvlVHCqaGisRSatliia.Ylmk...tknl....slneAyefvkerrskispnag
subfamily_PTEN_pd Subfamily PTEN 449-509 2.6e-06 22.5 In-house 117-173 (184) alignment 
Range on Protein: 449-509
Range on HMM: 117-173/184.0
IIVHCSAGIGRTGTIIVIDMLMENISTKGLdcdiDIQKTIQMVRAQRSGMVQTEAQYKFIY
..||| || ||||..||  .| ... .|      .. .  . .|.. .  |.  .| ....
vvvHCkaGkGRtGvlivayllkslllekae....ealelfaeaRtknkkgvtiPsqrRYve
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 269-400 3.6e-06 19.9 In-house 25-115 (169) alignment 
Range on Protein: 269-400
Range on HMM: 25-115/169.0
ENKGKNRYKNILPFDHSRVILQGRDSNIpGSDYINAnyiknqllgpdenaktyiasqgcleatvndfwQMAWQENSRVIVMTTREVEKGrNkcvpYWPEv
 |. |||    |   | || ||    .. |||||||                                .| |. |. |||.     .|  |    .||| 
cnetknrpagplapshtrvklqrvmedl.gsdyina................................rmiwetnasvivvlGdtddkn.n....fwpe.

gmQRAYGPYSVTNCGEHDTTEYKLRTLQVSPL
  .  |  .     ||  |    .|| .| | 
..kedyqlhpavilGewytdslyvrtdkvhpn
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 264-310 3.8e-06 21.0 In-house 42-84 (95) alignment 
Range on Protein: 264-310
Range on HMM: 42-84/95.0
EGQRPENKGKNRYKNILPFDHSRVILQGRDSnipgSDYINANYIKNQ
 |    |  |||. ||.|.| .||.|  .      |||||| ..   
vgsseanipknrflnifpydatrvvlttkrd....sdyinacfvdgy
subfamily_DSP19_pd Subfamily DSP19 441-496 7e-06 20.5 In-house 84-131 (152) alignment 
Range on Protein: 441-496
Range on HMM: 84-131/152.0
ESLPHAGPIIVHCSAGIGRTGTIiVIDMLMENIStkgldcdIDIQKTIQMVRAQRS
|.. . | ..|||.||. |. .. ||  ||.. .       .........||..| 
earskdgavlvHCnAGvSRsasv.viaylmkkee.......lsleealelvrearp
0048567 (Phosphotyrosine protein) phosphatases II 416-466 7.8e-06 20.3 In-house 43-97 (157) alignment 
Range on Protein: 416-466
Range on HMM: 43-97/157.0
S-WPDHGvPSEPGGVLSFLDQINQRQESLP-HAGPIIVHCSAGI---GRTGTIIVI
. . |.| | . . . .|  ..|.  ..|  . ..|.|||.||    |||.|.|  
dfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_DSP23_pd Subfamily DSP23 445-510 9.7e-06 20.3 In-house 83-140 (148) alignment 
Range on Protein: 445-510
Range on HMM: 83-140/148.0
HAGPIIVHCSAGIGRTGTIIVIDMLMEnistKGLDcdidIQKTIQMVRAQRSGMVQTEAQYKFIYV
..  . |||  | |||||..   .. |    ..|       ..|  || .| | |.|  | | .. 
kneavsvhcllgrgrtgtmlacylvke....rkla....aaeaiaevrrlrpgsvetveqeklvrd