Gene PTPRE in Homo sapiens

Synonym: HPTPE, PTPE, R-PTP-EPSILON, RP11-380J17.1, PTPRE

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRA
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP089_AA protein Get Run
HsapP089_AA_117-396 phosphatase_domain Get Run
HsapP089_AA_408-691 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRA_pd Subfamily PTPRA 103-430 8e-201 660.9 In-house 2-330 (330) alignment 
Range on Protein: 103-430
Range on HMM: 2-330/330.0
SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN
.||.||.|||||.|||.||||||||||||.|.||||||.||.|.||.|.|||.||||.||||..||||.|.||||||...|...|||||||.|||||||.
arsrsgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd

KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQpQLPDGC--KAPRLVSQLHFTS
|||||||||.|||.|||||.||||||||||||.|||||||||.|||||.|..|||||||.|||..||||||.|||..| ||||..  |..|||.|.||||
kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhfts

WPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT
|||.||||.||||||.|||||.||...||||||||||||||||||||.||......||.||||||||.|.|.|||||||||.||.|||..||||||||||
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt

ELDVSSLEKHLQTMHGTTTHFDKIGLEEEF
||||||||||||......|..|||||||||
eldvsslekhlqklynkitgtdkigleeef
subfamily_PTPRA_pd Subfamily PTPRA 445-694 1.5e-139 459.5 In-house 52-306 (330) alignment 
Range on Protein: 445-694
Range on HMM: 52-306/330.0
TGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG
. .   |..|.||..|.||||.|||||.|.|.|..|||||||||||..||.|||.|||...|||||||||||.||.|||||||..||...||.||||.||
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

SVTHGEITIEIKNDTLSEAISIRDFLVTlNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNhPITVHCSAGAGRTGTFIALS
.||.|.|..|....|.......|.|||. ..|.|..|...|.||||||..||..|.|.|..||..|...|.|..||... ||.||||||.|||||||.|.
lvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivld

NILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF-------IDIFS
..|||||||...|||..||.||||||.||||.|||||.|||....       .|..|
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss
subfamily_PTPRD_pd Subfamily PTPRD 114-441 3.5e-136 450.1 In-house 4-328 (564) alignment 
Range on Protein: 114-441
Range on HMM: 4-328/564.0
PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGhIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQE
||||..|.| ..   |..  .| ||.... .|  | |.| |||..|..|||| ||.. |||||.||...| . |||||||.||||......||.|||..|
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLpdgCKAPRLVSQLHFTSWPDFGVPFTPIGM
|..|||||||||.|.||||||.|.|....|||.|||..|  |||.. | .|... | ||.||.| .. .     .  | | | ||||||| ||| .. ..
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk...ssesreVrqFhFtsWPdhgvpesatsl

LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT
|....||..||. .||||||||||||||||||||||||.  ...|..||....|...|.||. ||||  || ||..|.||.   |.||.....|..||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

MHGTTTHFDKIGLEEEFRKLT-NVRIMKE
.. ......  ||| ||..|.  ..|  |
LaeveedtemtgleleFqrLatakeiele
0051299 (Phosphotyrosine protein) phosphatases II 113-395 2.1e-112 370.5 In-house 3-286 (288) alignment 
Range on Protein: 113-395
Range on HMM: 3-286/288.0
FPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQ
 .|.||.|.. .. . |.. ....|||. |.|  ...|.  |...||.|||||..|||.|||||.|| |||.. ||||||||||||. |.||||.|||..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQ-LPDGCKAPRLVSQLHFTSWPDFGVPFTPI
.||.|||||||||.. .|||||.| |.. |||.||||..|..|||.|.|.  ...|| |||.|......  |.||.. .| | ..|.|.|||.||| .| 
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 .|.||..|.. .. . ||.|||||||||||||||..| .. ....|..|||.|.| |.|.|||.|||| .|| |.|.|||||.
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 115-433 3.7e-111 366.2 In-house 2-318 (318) alignment 
Range on Protein: 115-433
Range on HMM: 2-318/318.0
IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET
|.||.||. .|   ..   .. ||.. |   . . |   .... |. |||| |||. ||.|| |..|.| . ||||||.|||||..|...||||.|  ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGML
..|||||||||.||.|||||...||  .|.|.|||..|  .||...| ... | | ||..|.| ..    ..... | | | |.||||| |||  . ..|
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr...teeeesrqvrqyhytsWpdegvpesgasll

KFLKKVKTLN-PVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT
.....|.. . .  ||||||||||||||||.||..|...  ..||. ||||..|...|.||. ||||. ||.|||..|||.   |||| | | | .... 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

MHGTTTHFDKIGLEEEFRKL
.. . ..  .  .. ||..|
lreqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 114-430 4.7e-110 362.6 In-house 4-318 (319) alignment 
Range on Protein: 114-430
Range on HMM: 4-318/319.0
PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQgTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQE
.|.|..|.|....  .   .....||. |  .  . ||. |.||||..||||.|||. |..||.||.|||.. |||||||.||||.|..||||.|.|...
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDgCKApRLVSQLHFTSWPDFGVPFTPIGM
|..||||||||..| ..||||.|.|. . |...|||..  ..||.. | .|.   | || |||......  .  .. | |.. ..|.||| .|| .  ..
tiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkksse.vet.RevkhfqyteWpdhdvPekatsl

LKFLKKVKTLNP-VHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQ
|..||...      ..|||||||||||||||||||.|||.  .. |. .|||..|||.| ||. |||.  ||.|||.||||.   ||||..|  |.. |.
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlk

TMHGTTTHFDKIGLEEEF
..    .   . ||| ||
qlaekvadtgetgleref
subfamily_PTPRD_pd Subfamily PTPRD 441-696 5.4e-109 360.4 In-house 38-287 (564) alignment 
Range on Protein: 441-696
Range on HMM: 38-287/564.0
ENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW
..... | ||| .| |. .|..|| .||.||. .|.| .||||||||||||..  .||||||||.|.||||||.|| .|.||||||...|....|| .||
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGRTGTF
|..|. |.||.|..... .  . ..||.| .. ..     ....| ||||||  ||. |.| ......|||  |.. . .....||.|||||| ||||||
PekgtetygeltVtleeeeeladyeirtfklkkkk.....ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtf

IALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDY
|... .|||.|.|...|..| || || ||..|||| ||| |.......... ... 
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0040438 (Phosphotyrosine protein) phosphatases II 118-414 2.1e-108 357.6 In-house 3-295 (317) alignment 
Range on Protein: 118-414
Range on HMM: 3-295/317.0
EHLEEEIRIRSADDCKQFREEFNSLPSGHIQgTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVND
..|.. .  . . |.....|||. |.| ..  |.. |...||..|||||.|||.|||||.|| |.|.. ||||||||.||...|.||||.|||...||.|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFL
||||||||.. .|||||.|.|.. |||.||||... .|||...| . ....| ..|.|......    |.. .| | ..|.|.|||.||| .|  .|.||
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfl

KKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTM
..|.. .. . ||..||||||||||||||... |. ... |..|||.| | ..|.|||..||| .|| |.|.|||||.....|  ..|.| ..|. .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
0050432 (Phosphotyrosine protein) phosphatases II 102-400 2.7e-108 357.2 In-house 13-304 (308) alignment 
Range on Protein: 102-400
Range on HMM: 13-304/308.0
LSRSPSGPKKYFPIPVEHLEEEIriRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILsqldGiPCSDYINASYIDGY--K
| |..| ........|..| . .   .|.| ....|||. |.|  . .... |...||..||||..|||.|||||.|    . . ||||||||.|||  |
lfrdtsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssk

EKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ---GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQL
 ..||||.|||...||.|||||||||.. .|||||.| |.. |||.||||.    |...||...| . .. || |||.|......    |..  | | ..
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn...lgdgesrtvthf

HFTSWPDFGVPFTPIGMLKFLKKVKTLNpvHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
|.|.|||.|||  |  .|.||..|.. .    ||||||||||||||||||..| .. ....|..||||| | ..| |||.|||| .|| |.|.|||||..
hytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

YGDT
.  |
lklt
0046845 (Phosphotyrosine protein) phosphatases II 135-402 2.8e-103 340.4 In-house 2-281 (284) alignment 
Range on Protein: 135-402
Range on HMM: 2-281/284.0
FREEFNSLPSGHIQG--TFELANKEENREKNRYPNILPNDHSRVILSQLDG-IPCSDYINASYIDGY-----KEKNKFIAAQGPKQETVNDFWRMVWEQK
..|||  |.|  .    ... |...||..||||..|||.|||||.|. ||| .. ||||||||.|||     . |.||||.|||...||.|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATIVMLTNLKERKEEKCHQYWPDQG-CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNP
. .|||||.| |.. |||.||||. | ..|||...| . .. |  |||.|......   . .. .| | ..|.|||||.||| .|  .|.||..|..|..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--VHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQ---KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL
     ||||||||||||||||||..| .. ....|.   .|||.| |.|.|.|||.|||| .|| |.|.|||||.... | |
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0036941 (Phosphotyrosine protein) phosphatases II 124-406 4.8e-103 339.8 In-house 4-288 (297) alignment 
Range on Protein: 124-406
Range on HMM: 4-288/297.0
IRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILsqlDGiPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVW
........  ....|| .|.. ...|... |...||.|||||..|||.||.||.|   |. . ||||||||.|||. |.||||.|||...||.|||||||
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EQKSATIVMLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVV--LVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKK
||.. .|||||.| |.  |||.||||.   . .|||...|.. .. |  | |||.|......    |.. .| | ..|.|.|||.||| .|  .|.|...
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespaslldfiel

VKTLNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMAMMH---AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSS
|.. ..     ||..|||||||||.||||..| |. ...    |..||..|.|  .|.|||..||| .|| |.|.||||......| . ...
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 403-698 2e-102 337.5 In-house 3-288 (318) alignment 
Range on Protein: 403-698
Range on HMM: 3-288/318.0
DVSSLEKHLQTMHGttthFDKIGLEEEFRKLTNVRIMKENMRTgNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP
.|. ||.|.. ..       .. |.||. .|. ..    .... . |.| .| | . |..||  || |.|. |.| .|||||..|||||.|  .||.|.|
svedleshvrrlre....sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaP

LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLnqpqaRQEEQVRVVRQFHFHGWPEIGIPA
|..|.||||||.|| .| .|||||...|| ..|. .||| .|| ..|....|.|... ..   .| | ||      ..||..|.|||.|.  ||. |.|.
lpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.....teeeesrqvrqyhytsWpdegvpe

EGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYAN
.| ...||.  |.| ||..|..||.|||||| ||||.|||.. .|||.|||.|.|||| || || ||. |||| .||||.|.|.....  .  ...
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0039614 (Phosphotyrosine protein) phosphatases II 107-400 4.7e-102 336.7 In-house 6-294 (297) alignment 
Range on Protein: 107-400
Range on HMM: 6-294/297.0
SGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQgtFELANKEENREKNRYPNILPNDHSRVILSQLDGI-PCSDYINASYIDGYKE-KNKF
.  ....|||...|.  .... |... ....|| .|.|  .   .. |...||..||||..|||.|||||.|. .||  . ||||||||.|||.  ..||
dallesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

IAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEeKCHQYWPDQGCwTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKapRLVSQLHFTSWPDF
||.||| .|||.|||||||||.. .|||||.|.|..  ||.||||. |  |||...| . .. .| .||.|......   .|.   | | ....|.|||.
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...nges..rtvthfqytgwpdh

GVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT
||| ..  .|.||..|.. .      ||..||||||||||||||... |. ... |..|||.| |...|.|||..|||. || |.|.||||......|
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 114-395 1.3e-101 335.0 In-house 1-277 (278) alignment 
Range on Protein: 114-395
Range on HMM: 1-277/278.0
PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIqGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQE
||.|..|.. .. . ..... ...|| .|.| .. .|.. |...||..||||..|||.|||||.|| |.| . ||||||||.|||. ..||||.||| .|
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPdQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGM
||.||||||||... ||||||.|.|.. .||.|||| .| .|||...| . .. .| |||.|.... .    |.. .| | ..|...|||.||| ..  .
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslsll

LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
|.|||.|.. ..   ||..||||||||||||||... .. ... |..||..| |...|.|||..|||..|| |.|.|||||.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 398-697 2.7e-101 333.7 In-house 1-297 (298) alignment 
Range on Protein: 398-697
Range on HMM: 1-297/298.0
GDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDY
|.||.....|...|| .   . ... .|...||..|..|   | .|... .. |.| || |  .||..|. ||.|. . ..| .|||||||...|.... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTlnqpqARQEEQVRVVRQFHFHGW
|||||.|| .||||||||..| .. ||||||...| .. |. .|||.||. |.||||......     . .| . |.      ..||. | |||.||  |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvs.....kkkeekerevrqlhftsW

PEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSD
|. |.|.. . ..||.. |...|||.||.|..|.|||| ||.|||||.. .|||||.|  .||||.|| || .||..||| ||| |.|..|....| |.|
pdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

YA
..
ei
0047943 (Phosphotyrosine protein) phosphatases II 126-395 3.3e-101 333.6 In-house 5-272 (273) alignment 
Range on Protein: 126-395
Range on HMM: 5-272/273.0
IRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILsqldGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQ
...... ....|||. |.|  ...|.. |...||..||||..|||.|||||.|    | . ||||||||.|||. |.||||.|||...||.|||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KSATIVMLTNLKERKEEKCHQYWPDQG---CWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT
.. .|||||.| |.. |||.||||. |    .|||...| . .. .  |||.|......    |.. .| | ..|.|.|||.||| ..  .|.|...|..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltn...lgtgesrtvthfhytgwpdhgvppslesllefielvrk

LNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 .    . ||.|||||||||||||||..| .. ....|..|||.| | ..|.||| ||||  || |.|.|||||.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 115-409 3.6e-101 334.1 In-house 1-301 (563) alignment 
Range on Protein: 115-409
Range on HMM: 1-301/563.0
IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQG--TFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCS-DYINASYIDGYKEKNKFIAAQGPK
.||..... .    ||. . | |||..| | .|.   . | ..|.||..|||| ||.. |.||| ||.| |.  . |||||.|||||. ...|||.||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

QETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQP---QLPDGCKAPRLVSQLHFTSWPDFGVPF
..|..|||||.|||..|.|||.|||.||. .||..||| ..  |||...|  ..  ||. ||.|.. |.    .  . |.  .|| | |.|.||| ||| 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE
 ..  |.| || .. |. .|||||||||||||||||.||.|...  ...|..|.||.|. .|| ||. .|||  ||.|...||||  . ..|||  . .|
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

K
.
e
0045450 (Phosphotyrosine protein) phosphatases II 110-396 2.1e-100 331.7 In-house 4-305 (307) alignment 
Range on Protein: 110-396
Range on HMM: 4-305/307.0
KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHI--QGTFELANKEENREKNRYPNILPNDHSRVILSQLDGI-PCSDYINASYI--------DGY
. . .|....|. ..... .|.   ...||..|.| ..   |... |...||..||||..|||.||.||.|| |||  . ||||||||.        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

KEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW-TYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLH
. |.||||.|||..|||.|||||.|||.. .|||||.|.|.. |||.||||| | . ||||..| . .  .| .||.|......   ||.. .| | ..|
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfh

FTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALL
.|.|||.||| ..  .|.|...|.. .      ||..||||||||||||||... |. ....|..   ||..| |...|.|||..||.  || |.|.|||
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

EYYL
|..|
elll
0051299 (Phosphotyrosine protein) phosphatases II 398-690 2.8e-100 330.7 In-house 1-286 (288) alignment 
Range on Protein: 398-690
Range on HMM: 1-286/288.0
GDTELDVSSLEKHLQTMHgtttHFDKIGLEEEFRKLTNVRIMkENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFI
||||..|..|.|......    . .. ||.|||..|... ..  ......||.|..| |   |.||| .||.||.  |.| .||||||.||||..|  ||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPqARQEEQVRVVRQFHFHGWPE
|||||| .||||||||.||.....|||||...|... ||.||||..||.|.|.||..... .  . . .| . || ..   ......| |..||...||.
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldl.ldgdgesrtvthfhytnwpd

IGIPAEGKGMIDLIAAVQKQQQqTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 |.|   . ..|.. .|.|...  |..|. |||||| |||||||||  .||....|| .||..||| || |||.||||.|||.|.|... ...
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRK_pd Subfamily PTPRK 117-431 1.6e-98 324.4 In-house 6-313 (314) alignment 
Range on Protein: 117-431
Range on HMM: 6-313/314.0
VEHLEEEIRIRSADDCKQFREEFNSLPSGhiqgtFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVN
|. | ..| .  . ..  |.||..||. |     .. |.|.|||||||. .||. |.|||.| ..|| | ||||||..||.||  ..||..|||.||||.
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWtYGNIRVCVEDCVVLVDYTIRKFCIQpQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKF
||||.|.....|.|||||.|.|    || .|||...   ||.|.| . .. .| .. .| | .. .|  | .. |.| |..|..|||..||    |.||.
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrve.klargqeeirevrqfqflgWpdhdvPvsatgllkl

LKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHG
...||. .. .||.|||||||| |||||||.|| .. |.. |. ||||. |  .|.... ||.|  ||.|||...||  | |.| . || ..     .  
vrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesir

TTTHFDKIGLEEEFR
  .. .   |.|||.
ldpqtnssqlkeefq
subfamily_PTPRB_pd Subfamily PTPRB 113-395 6.4e-98 322.4 In-house 5-285 (293) alignment 
Range on Protein: 113-395
Range on HMM: 5-285/293.0
FPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQ
 || .|..|| ..  .||.  .| ||...| .   . . . |....||.|||| |||| ||||| |..|.. . ||||||.||.||. ...|||.|||  
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ-GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpdgCKAPRLVSQLHFTSWPDFGVPFTPI
|||.||||||||.|| .|||||.| |.  .||..|||..    .||.|.| .    .| |..||.. |.       |. | | |.|||||||.||| .. 
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektk

GMLKFLKKVKTLN--PVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 .|.|...|..      ...||||||||||||||||| .| ..  .. |. ||.| .|...|..| ..|||  || ||.|..|.. 
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Ptp69D_pd Subfamily Ptp69D 115-414 9.3e-98 322.1 In-house 4-305 (307) alignment 
Range on Protein: 115-414
Range on HMM: 4-305/307.0
IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQET
|... |||... |  |    . .|...|.. .|. . . ..|.||  ||||..| . |. ||.|... |   |||||||.| |||||.||||||.| ..|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

VNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDG--CKAPRLVSQLHFTSWPDFGVPFTPIG
..|||||..||.. .||||.||.| ...||..|||..    ||.| | . .     ||.||.. .  .  ..   .. | | | |.|.|.|. || .. |
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

MLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQ
.||....|. |.  . .||||||||||||.|.|. .| ..  ..||.|||.||.|  .|.||. .||   ||.|.|.|||.|  ||||. || .||....
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

TM
..
rl
0050432 (Phosphotyrosine protein) phosphatases II 414-697 1.7e-97 321.8 In-house 32-306 (308) alignment 
Range on Protein: 414-697
Range on HMM: 32-306/308.0
MHGTTTHFDKIGLEEEFRKLTNVRImKENMRTGNLPANMKKARVIQIIPYDFNRVILsmkrgQEYTDYINASFIDGY--RQKDYFIATQGPLAHTVEDFW
..     .|. .|||||..|..| .  .......||.|..| |   |.||| .||.|     .| .||||||..|||  ...  |||||||| .||||||
lkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE---GSVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMI
||.||.....|||||. .|... ||.||||.|   ||...| .|..... .  . . .| . .| ..     ....|.|..||...||. |.| . . ..
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.....dgesrtvthfhytnWpdhgvPpspeill

DLIAAVQKQQqqtGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA
|.. .|.|..   ...|| |||||| |||||||||  .||....|| .|||.||| || |||.||||.|||.|.|.......  .  ..
dflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 120-401 5.5e-97 319.6 In-house 14-296 (298) alignment 
Range on Protein: 120-401
Range on HMM: 14-296/298.0
LEEEIRIRSADDCKQFREEFNSLPSGHI---QGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVN
|..   .. . .  .. .||. | |.     . . | |.|.||..||||..|.. |.|||.|.. |.   |||||||....||..| |||.|.| .|||.
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDgckAPRLVSQLHFTSWPDFGVPFTPIGMLKF
||||||.|....||||||||.| .. |.|.||||.|  |||.|.| .    .  |...||. .. .  .     | | ||||||||| ||| .   .|..
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldl

LKKVKTlNPVHAG--PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTE
|.||.. .. .||  |..|.|||||||.||||.||...  ...||.||||. | ..|..||..|||  ||.|||.| ||.   ...|
lrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
DSPc_SM00195 134-395 1e-96 318.7 In-house 1-262 (263) alignment 
Range on Protein: 134-395
Range on HMM: 1-262/263.0
QFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML
...|||..| .   . ... |.|..|..|||| ||||.||.||.|.. .. . ||||||.||.|...|.|.||.|||...||.||||||||.|. .||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLV-DYTIRKFCIQPQLPdgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGP
|. .|...|||..|||..  | .|.|.|.|.. ..     ....|.. .. . .   . .| | |.....||| ||| ..  .|..|..||. .    ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
|||||||||||||||..|| ..  ...|.|||.|| |...|.|||.||||..||.|||.|.|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 134-395 1e-96 318.7 In-house 1-262 (263) alignment 
Range on Protein: 134-395
Range on HMM: 1-262/263.0
QFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML
...|||..| .   . ... |.|..|..|||| ||||.||.||.|.. .. . ||||||.||.|...|.|.||.|||...||.||||||||.|. .||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLV-DYTIRKFCIQPQLPdgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGP
|. .|...|||..|||..  | .|.|.|.|.. ..     ....|.. .. . .   . .| | |.....||| ||| ..  .|..|..||. .    ||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
|||||||||||||||..|| ..  ...|.|||.|| |...|.|||.||||..||.|||.|.|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 398-694 1.3e-96 318.5 In-house 1-287 (319) alignment 
Range on Protein: 398-694
Range on HMM: 1-287/319.0
GDTELDVSSLEKHLQTMHGttthFDKIGLEEEFRKLTNVRIMkeNMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFI
||||..|  |...|....       . .||.||..| .   .  .... . . | || |  .|..||  ||.||   |.| .|||||||||||.... ||
gdteievqeLkerlkalas....tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfi

ATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVtlnQPQARQEEQvRVVRQFHFHGWPE
|||.||..|.||||||.|| .|...||||...|. . |. .|||.|  .. |.........   | . ||.. .   .... . |  | | .|..  ||.
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl...nkkssevet.RevkhfqyteWpd

IGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFS
 ..| ......||.  ..| ...| . ||.||||||.|||||||.|. .||||| ||.||||. |. ||.||. |||. |||.|.|... .......
hdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 114-414 3.8e-95 313.9 In-house 15-310 (319) alignment 
Range on Protein: 114-414
Range on HMM: 15-310/319.0
PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGT-FELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQ
..|.....  ..    || .... ||. ..   ....  . || ..|..|||. |||. |...| | .|.|.  |||||||...||. |.|.||||||..
dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPld

ETVNDFWRMVWEQKSATIVMLTnlkerkEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGVPFTPIG
.|..|||||.||....|||.||      ..|| |||| ..  ....  | |.      .|..|.. .  .     |  | . | ||  ||| |||  |. 
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsed..gkekdirkitqfhflGwpdvGvpdypsd

MLKFLKKVKTLNP--VHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH
.....|||. |.    |  .|||||||||||||..||.|... .|. |..|||..||  .|.||...||  .|| ||| |||| .|.| ... .  .  .
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

LQTM
|. .
leel
0046845 (Phosphotyrosine protein) phosphatases II 425-697 5.6e-95 313.2 In-house 1-281 (284) alignment 
Range on Protein: 425-697
Range on HMM: 1-281/284.0
GLEEEFRKLTNVRIMKE-NMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFIDGY-----RQKDYFIATQGPLAHTVEDFWRMIWEW
||||||..|... .. . ......||.|..| |  .|.||| .||.|..  |. | .||||||..|||     ..|  |||||||| .||||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSHTIVMLTEVQEREQDKCYQYWPTEG-SVTHGEITIEIKNDTLSEAISIRDFLVTLNQPqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK
....||||||  |... ||.||||.|| ..|.|..|..... .  . . .| . .| ...    ....| |..||...||. |.|.. . ..... .|..
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy....tgesrtvthfhytswpdhgvppspedlleflrlvre

QQQQ-TGNHPITVHCSAGAGRTGTFIALSNILERVKAEG---LLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA
....  |..|| |||||| |||||||||  .||....||    .||..||| || |||.||||||||.|.|.......  .  ..
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0040438 (Phosphotyrosine protein) phosphatases II 420-690 3.1e-93 307.8 In-house 14-276 (317) alignment 
Range on Protein: 420-690
Range on HMM: 14-276/317.0
HFDKIGLEEEFRKLTNVRIMkeNMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKS
. |. .|.|||..| .. .   ......||.|..| |   |.|||..||.||   | . .||||||..||...|. |||||||| .||||||||.||...
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

HTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQ
..||||||  |... ||.||||.....|.|..|..... .  . | .| . |. .     .....| |..||..|||. |.|   . ..|.. ||.....
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.....gdsesrtvthfhytgWpdhgvppspdllldfleavreale

qTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
  ...|. |||||| ||||||||.  .||... || .||..||| || |||..|||.|||.|.|.......
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 123-393 7e-93 305.8 In-house 11-277 (288) alignment 
Range on Protein: 123-393
Range on HMM: 11-277/288.0
EIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV
 . . ||.. ..| ||.|||.. . . . . ... .| .||||.|||| |. || | .|.  . .||||||||||.|.|.|.||.||| ..||||||..|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WEQKSATIVMLTNLKERKEEKCHQYWPDQGC-WTYGNIRVCVEDCVVLVDYTIRKFCIQpqlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVK
.|.|. ||||||.| |. ..||..||||..    ||.. | . .   | |.. ||. ..       |  . . |.....||| |||     .|..|..||
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvk

TLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
. |.  .|||.||||||||||||||..||.. ....|...||...|...|.||...|||  || |||..||.
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0040439 (Phosphotyrosine protein) phosphatases II 150-396 9.6e-93 305.6 In-house 2-247 (249) alignment 
Range on Protein: 150-396
Range on HMM: 2-247/249.0
TFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP
... |...||..|||||.|||.|||||.|| |.| ..||||||||||||. |..|||.||| .|||.|||||.||... .|||||.|.|.. |||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIV
..| ..||...| . .. |. |||.|......    ... .| | ....|.|||.||| ..  .|.|...|.. .      ||..||||||||||||||.
lggsleygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
.. |. ... |..||..| |. .|.|||..||.. || |.|.||||..|
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 114-415 1.3e-92 305.2 In-house 3-303 (305) alignment 
Range on Protein: 114-415
Range on HMM: 3-303/305.0
PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGhiQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQE
.| ...|.. |.  .....|.. ....||..   . .... .||.|..|||. .| . |..|.||.. .  . ||||||||.||||.|.|.|.|||| ..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW--TYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGVPFTPI
||.||||...| |  ||||||.|.| ...||.||||..      .|.. | ...     ||..||..|  .  |. |  | |.|...|.||| ||| .. 
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisie..dedkesrtvlqyqltdWPdhGvpqfat

GMLKFLKKVKTLNPVHAG-PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH
 .|...|.|.       | |..|||||||||||.||..| ..  ...|. ||||| . ..|..|..||||  ||.|...|| |.   |||.. .| |. .
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

LQTMH
.. ..
vnklk
0047943 (Phosphotyrosine protein) phosphatases II 419-690 7.4e-92 302.9 In-house 7-272 (273) alignment 
Range on Protein: 419-690
Range on HMM: 7-272/273.0
THFDKIGLEEEFRKLTNVRImKENMRTGNLPANMKKARVIQIIPYDFNRVILsmkrGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWK
. ... .|.|||..|... .   ......||.|..| |   |.||| .||.|    |.. .||||||..|||..|  |||||||| .||||||||.||..
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

SHTIVMLTEVQEREQDKCYQYWPTEG---SVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQ
...||||||..|... ||.||||.||   |.|.|..|..... .  . . .| . .| ..      ...|.|..||..|||. |.|.  . ....| .|.
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.....tgesrtvthfhytgwpdhgvppslesllefielvr

KQQQQT-GNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
|..... .|.|. |||||| |||||||||  .|.....|| .||..||| || |||.||||.|||.|.|... ...
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 420-690 2.6e-91 301.3 In-house 9-277 (297) alignment 
Range on Protein: 420-690
Range on HMM: 9-277/297.0
HFDKIGLEEEFRKLTNVRImKENMRTGNLPANMKKARVIQIIPYDFNRVILsmkrGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKS
 ... .|..||..|... .   ......||.|..| |   |.|||..||.|    ..| .||||||..|||..|  |||||||| .||||||||.||...
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

HTIVMLTEVQEREQDKCYQYWPTE--GSVTHGEITIEIKNDTL--SEAISIRDFLVTLNqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQ
..||||||. |..  ||.||||.|  .|.|.|..|.. .. .   .. . .| . || .     .....|.|..||..|||. |.|   . ..|.| .|.
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.....gngesrtvthfhytgwpdhgvpespaslldfielvr

KQQQQT-GNHPITVHCSAGAGRTGTFIALSNILERVK---AEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
|..... ...|. |||||| ||.|||||.  .|....    || .|...|||.|| |||..|||||||.|.| ......
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 410-693 3.7e-91 300.9 In-house 18-292 (297) alignment 
Range on Protein: 410-693
Range on HMM: 18-292/297.0
HLQTMHGTTTHFDKIGLEEEFRKLTNVRImkeNMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFIDGYRQ-KDYFIATQGPLAHTV
.|  ... .. ..| .|..|| .| .. .   ......||.|..| | . |.|||..||.|....|. . .||||||..|||.. .. |||||||| .||
vldlllllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

EDFWRMIWEWKSHTIVMLTEVQEREQdKCYQYWPTEGSvTHGEITIEIKNDTLSEAISIRDFLVTLnqpqarqEEQVRVVRQFHFHGWPEIGIPAEGKGM
||||||.||.....|||||.  |... ||.||||.||. |.|..|.. .. .  . . .| . ||        ....| |..|...|||. |.|   . .
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.......ngesrtvthfqytgwpdhgvppslell

IDLIAAVQKQQQQT-GNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF
.... .|....... ...|. |||||| ||||||||.  .||... || .||..||| || |||..|||..||.|.|.......  .
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 153-395 4.9e-91 299.4 In-house 3-242 (250) alignment 
Range on Protein: 153-395
Range on HMM: 3-242/250.0
LANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEkCHQYWPDQG
.|.| .|.||||| .|.. |.|||.| . .|   |||||||...||.|.. |||.||| |.|..||||||.|.||.|||||||||| ... .||||| ..
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPdgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV-HAGPIVVHCSAGVGRTGTFIVIDAM
  .||...| . .  .  |||.||. .  .     .  |.| ||||..||| ||| .   .|..||||.. ..  ...|..|.|||||||.|.||.|||.
aekyGdvtvsllskeefadytkrklklskakk...aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
.  .. |..||||... ..|..||..|..  || |.|...|.. 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
0043336 (Phosphotyrosine protein) phosphatases II 418-689 6.3e-91 299.9 In-house 14-276 (278) alignment 
Range on Protein: 418-689
Range on HMM: 14-276/278.0
TTHFDKIGLEEEFRKLTNVRImkENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEW
    .| .|..|| .|... .  .......||.|..| |   |.|||..||.||.  | . .||||||..|||.... |||||||| .||||||||.||.
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

KSHTIVMLTEVQEREQDKCYQYWPtEGSVTHGEITIEIKNDTLSEAISIRDFLVTLnqpqaRQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQ
...|||||||  |... ||.|||| .||.|.|..|.. .. .  . . .|.. ||      ... ..| |...|..|||. |.|   . ..|.. ||...
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn.....lgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

QQqTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
.. . |.|. |||||| |||||||||  .||... || .|...||| || |||..|||..||.|.|......
le.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045098 (Phosphotyrosine protein) phosphatases II 130-399 6.4e-91 299.8 In-house 4-276 (278) alignment 
Range on Protein: 130-399
Range on HMM: 4-276/278.0
DDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIlsqldgipcsDYINASYIDGYkeKNKFIAAQGPKQETVNDFWRMVWEQKSAT
... ... ||  |.. .| .... |....|..||||..|||.|||||.          |||||||||||  ..||||.|||...||.|||||.||... .
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQ-LPDGCKAPRLVSQLHFTSWPDFGVPFTP--IGMLKFLKKVKTLNPV
|||||.|.|.. |||.||||..|..|||...|..... || |||.|.. ..   . .    .| | .||...|||.||| .|    .|..|. ..  . .
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------HAGPIVVHCSAGVGRTGTFIVIDAMMAMMhaEQKVDVFEFVSRIRNQRPQ-MVQTDMQYTFIYQALLEYYLYGD
             . ||..||||||||||||..... |. ..  |..||..| |. .|.|||. .||. .|| |.|..|||..|.|.
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 148-415 8.9e-91 299.3 In-house 13-275 (284) alignment 
Range on Protein: 148-415
Range on HMM: 13-275/284.0
Q-GTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTnlkerkEEKCHQ
.  . . || ..|..|||. .||. |...| | .|.|.  |||||||.| ||. |.|.||.|||...|..|||||.||....|||.||      ..|| |
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNP--VHAGPIVVHCSAGVGRTGT
||| ..  .... .| |.      .|..|.. .  .     |  | . | ||  ||| |||  |. .....|||. |.    |  .|||||||||||||.
ywplkivikeerfkvkvdsveeseeyvvrdielsed..gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMH
.||.|... .|. |..|||..||  .|.||...||  .|| ||| |||| .|.| ... .  .  .|. . 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0042113 (Phosphotyrosine protein) phosphatases II 152-394 2.7e-90 297.3 In-house 2-242 (245) alignment 
Range on Protein: 152-394
Range on HMM: 2-242/245.0
ELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ
. |...||..||||..|||.||.||.||  .| . ||||||||.|||. ..||||.||| .|||.|||||.||... ||||||.. |.. .||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNP-VHAGPIVVHCSAGVGRTGTFIVIDA
. .|||...|.. .. .| |||.|......   .|.. .| | ..|...|||.||| ..  .|.||. |..       ||..||||||||||||||... 
esltygdftvtllseehlddytvrtlevtn...lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
|. ....|..|...| | ..|.|||..|||. || |.|.||||.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 113-402 6e-90 296.4 In-house 4-286 (315) alignment 
Range on Protein: 113-402
Range on HMM: 4-286/315.0
FPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQgTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQ
 |||...|   .  . |   . |.....|.| |...  .. |.| ||..|||| ||.. |.||| |  |.  | |||.||..||||. |...||||||. 
qpipldqlityvaqkkastkngfkqdyesipggqlh.pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQgCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpdgcKAPRLVSQLHFTSWPDFGVPFTPIG
..|.||||.|.|.. ..||||||| |....|. .||||.   .||.| |   .  |  .||.| . .  .     .  | | |||.||||| |||   | 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg.....dnirevvqlhytswpdmgvpkytip

MLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL
.... ..||  .   .|.|||||||||||||||| .||..  ..||. .||..|. ..|..| .|||.  || |||.|||| .. ||| .
lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi
0045450 (Phosphotyrosine protein) phosphatases II 417-689 2.2e-88 292.2 In-house 20-303 (307) alignment 
Range on Protein: 417-689
Range on HMM: 20-303/307.0
TTTHFDKIGLEEEFRKLTNVRIM-KENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQ-EYTDYINASFI--------DGYRQKDYFIATQGPLAHT
...  .. ||..||.|| .| ..   ......||.|..| |   |.||| .||.||   |. | .||||||..        |||..|. |||||||| .|
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV-THGEITIEIKNDTLSEAISIRDFLVTLNqpqaRQEEQVRVVRQFHFHGWPEIGIPAEGK
|||||||.||.....||||||  |... ||.||||.||.. |.|..|.. .. .  . . .| . || .    ......| |..||..|||. |.|   .
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl....dgtgesrtvthfhytgwpdhgvppsfe

GMIDLIAAVQKQQQQT-GNHPITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
 ..|.| .|.| .... ...|. |||||| ||||||||.  .|.....||    .|...||| || |||..||..|||.|.|......
elldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 447-698 2.5e-88 290.5 In-house 5-250 (250) alignment 
Range on Protein: 447-698
Range on HMM: 5-250/250.0
NLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDkCYQYWPTEGSV
. |.| .| |  .||..|  ||.|  ..|.. .|||||||..||.... |||||||| .|.||||||..| || ||||||...| |.  . ||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

THGEITIEIKNDTLSEAISIRDFLVTLNqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNI
..|..|......     . .| . .. .     .... |.|||.||  ||. |.|.. . ...|.  ||..|||.|| |. |.|||| ||.|.|||.. .
kyGdvtvsllskeefadytkrklklska.....kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYAN
|||.| |  .|||. .| || .|||.|..|||| |.|.... ..| ..|||.
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 421-688 1.5e-87 288.9 In-house 31-289 (319) alignment 
Range on Protein: 421-688
Range on HMM: 31-289/319.0
FDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH
 |.  || |||..... .   ..   ||. |  | |.|.|...| |.| |    |.|..|||||||..||..|| .||.||||  |..||||||||... 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

TIVMLTevqereQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTlnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK-QQQ
|||.||      .||| |||| .. .....  ....  . ..   .||. ..    .  .|...| ..|||| |||. | |  .  .. |.  |.. ...
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdiels....edgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

QTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
. ....| ||||||.||||..|.|  .|.|.| |  .||.. |. || ||...|| | || |.|  . .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
Y_phosphatase Protein-tyrosine phosphatase 159-393 1.7e-87 288.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 159-393
Range on HMM: 1-235/235.0
NREKNRYPNILPNDHSRVILsqlDGIP-CSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWT
|..||||..||| |..|| |   .| .  ||||||.|..|||||.||||.||| ..|..|||||||..|. .|||||.|.|...|||.||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVCVE-DCV-VLVDYTIRKFCIQPQLPDGckAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA
||.|.| .. .      .||.||. .. .  .   ..| |.|||.|.||| ||| .| ..|....||.. .  . ||.||||||||||||||...|... 
ygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
...||..|||...|...|.|||.|||.  || |.|.|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 159-393 1.7e-87 288.1 In-house 1-235 (235) alignment 
Range on Protein: 159-393
Range on HMM: 1-235/235.0
NREKNRYPNILPNDHSRVILsqlDGIP-CSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWT
|..||||..||| |..|| |   .| .  ||||||.|..|||||.||||.||| ..|..|||||||..|. .|||||.|.|...|||.||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVCVE-DCV-VLVDYTIRKFCIQPQLPDGckAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA
||.|.| .. .      .||.||. .. .  .   ..| |.|||.|.||| ||| .| ..|....||.. .  . ||.||||||||||||||...|... 
ygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
...||..|||...|...|.|||.|||.  || |.|.|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
DSPc_SM00195 426-690 6.3e-87 286.6 In-house 2-262 (263) alignment 
Range on Protein: 426-690
Range on HMM: 2-262/263.0
LEEEFRKLTNVRIMKeNMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVML
|.|||.|| . .  | ...... ..|..| |  .|.||| .||.|. . ..| .|||||..|.|...|  .||||||| .||||||||.|| |...||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TEVQEREQDKCYQYWPTE--GSVTHGEITIEIKNDTLSE-AISIRDFLVTLNQPqarqeEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTg
|| .|... ||..||| |  |. |.|.|...... .  .  | .|.. .| ...     |. | |.|.....||. |.| . | ...|. ||.|..... 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
..|| |||||| ||||||.... ||.....|  .|.|. ||.|| |||.|||||||| |.|... ..|
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 426-690 6.3e-87 286.6 In-house 2-262 (263) alignment 
Range on Protein: 426-690
Range on HMM: 2-262/263.0
LEEEFRKLTNVRIMKeNMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVML
|.|||.|| . .  | ...... ..|..| |  .|.||| .||.|. . ..| .|||||..|.|...|  .||||||| .||||||||.|| |...||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TEVQEREQDKCYQYWPTE--GSVTHGEITIEIKNDTLSE-AISIRDFLVTLNQPqarqeEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTg
|| .|... ||..||| |  |. |.|.|...... .  .  | .|.. .| ...     |. | |.|.....||. |.| . | ...|. ||.|..... 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.

NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
..|| |||||| ||||||.... ||.....|  .|.|. ||.|| |||.|||||||| |.|... ..|
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 422-692 1.5e-86 285.3 In-house 20-285 (305) alignment 
Range on Protein: 422-692
Range on HMM: 20-285/305.0
DKIGLEEEFRKLTNVrimKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHT
.. |||.....|..    .| .  |.  || .| |. .|...|..|.||. |  .. .||||||..|||..|. .|..|||| .||.||||.|.| | .|
sdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLTEVQEREQDKCYQYWPTEGSV--THGEITIEIKNDTLSEAISIRDFLVTLNQPqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQ
|||||...| ..|||.||||.. .    .||...|.|. .  .   .|.. .. ..     ... |.| |...  ||. |.| .   ...||  |||.|.
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

QTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDI
.  . |..|||||| ||||.|||..  |||.|.|. .|||. .| || .|. |||||.|| |.. .... |  
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPRB_pd Subfamily PTPRB 404-690 3.8e-86 283.8 In-house 9-285 (293) alignment 
Range on Protein: 404-690
Range on HMM: 9-285/293.0
VSSLEKHLQTMHGTtthfDKIGLEEEFRKLTNVRImKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPL
....|.|...|.      ..... ||. .| .|   .... . .|..| .| |  .|.||| .|| |.  .... .|||||..|.||...  ||||||||
lekfeehvkkmkad....sdlrfseeyeelkavgk.dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE-GSVTHGEITIEIKNDTLSEAISIRDFLVTLnqpqarqEEQVRVVRQFHFHGWPEIGIPA
 .||.|||||.|| ||..|||||.. |. . || .|||..  .|..|.|........  |   ||.....        |.. | |||.||  ||. |.| 
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.......ekeerkvrqyhftsWpdhgvPe

EGKGMIDLIAAVQKQQ-QQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
. | ..|.. .|.... ... ..||.|||||| ||||||||| ..|.... | ..|.|  | .|| .| ..||| .|| | ...|.|..
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
Y_phosphatase Protein-tyrosine phosphatase 451-687 1.4e-85 281.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 451-687
Range on HMM: 1-234/235.0
NMKKARVIQIIPYDFNRVILsmkRGQEY-TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP--TEGSVT
|.|| |  .|.|||..|| |   .|.|  .|||||....||..|  |||||||| .|.||||||.|. |...|||||...|... || ||||  .|.|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGEITIEIK-NDT-LSEAISIRDFLVTLNQPQArqeeQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGRTGTFIALSN
.|.|..|.| . .  .... .|.. .. .. .     . | |.|.|...||. |.|.. |...||| .|.|.. .. ..|..||||||.||||||.||. 
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQ
.||...||. .||.|.||.|| |||.|||.||||.|.||...
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 451-687 1.4e-85 281.8 In-house 1-234 (235) alignment 
Range on Protein: 451-687
Range on HMM: 1-234/235.0
NMKKARVIQIIPYDFNRVILsmkRGQEY-TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP--TEGSVT
|.|| |  .|.|||..|| |   .|.|  .|||||....||..|  |||||||| .|.||||||.|. |...|||||...|... || ||||  .|.|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGEITIEIK-NDT-LSEAISIRDFLVTLNQPQArqeeQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGRTGTFIALSN
.|.|..|.| . .  .... .|.. .. .. .     . | |.|.|...||. |.|.. |...||| .|.|.. .. ..|..||||||.||||||.||. 
ygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQ
.||...||. .||.|.||.|| |||.|||.||||.|.||...
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 428-689 2.5e-85 281.4 In-house 2-255 (284) alignment 
Range on Protein: 428-689
Range on HMM: 2-255/284.0
EEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTe
 |||..... .   ..   ||. |  | |...|...| |.| |    |.|..|||||||| ||..|| .|||||||  |..|||||||| .. |||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

vqereQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTlnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK-QQQQTGNHPI
     .||| |||| .. .....  ....  . ||   .||. ..    .  .|...| .||||| |||. | |  .  .. |.  |.. .... ....|
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdiels....edgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhrani

TVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD-F
 ||||||.||||..|.|  .|.|.| |  .||.. |. || ||...|| | || |.|  . . .
vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 134-435 2.9e-85 281.3 In-house 19-316 (515) alignment 
Range on Protein: 134-435
Range on HMM: 19-316/515.0
QFREEFNSLPSGHIQGTfELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML
 | |||. ||   |     .|..| | .|||| |||| | .||.|  ..  | |||.||||| ...  . .||.|||.. .|.||||.|.... .||.|.
lfseefhdlpgpniypq.tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpdGCKaPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPI
|.|||    || .||||       .|.|.| .       . ..||. .      | .  | | | ||| ||| |||     .||..|.||. .   . |.
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk....gdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

VVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR
..|||||||||| .| || ..| ..  . ||||.||  ||..||..|||. ||.|||.|.||. |. .| . |  .  ||| .| .     .  . .||.
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefq

KLTN
 | .
tlks
subfamily_PTPN6_pd Subfamily PTPN6 131-395 1.1e-84 279.0 In-house 24-297 (306) alignment 
Range on Protein: 131-395
Range on HMM: 24-297/306.0
DCKQFREEFNSLPSGHIQGTFE--LANKEENREKNRYPNILPNDHSRVILSqLDGIPCSDYINASYIDGY--KEKNKFIAAQGPKQETVNDFWRMVWEQK
. . | |||..|   . . ...   ..| ||.||||| |||| ||.||||.  ...| ||||||.||..   ......||.||  ..||.|||||||...
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SATIVMLTNLKERKEEKCHQYWPDQGCW-TYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT---
|  |||.|.  || .||| .||||.    .||.|.|   .   | ||..|.. .. .  .  |  | | |.||.|||| |||  |  .|.||..|..   
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

-LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHA---EQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 |.  .|||||||||||.||||||||||... ...    . ..|. ..|  .|.|| ..|||. || |.|.|. .| 
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 422-690 1.5e-84 278.4 In-house 19-279 (288) alignment 
Range on Protein: 422-690
Range on HMM: 19-279/288.0
DKIGLEEEFRKLTNVRIMKENmRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHT
.. |..||...|...   |..  .|.|. | || |  .|.|||..|| |     .. .||||||.|||...|  .||||||||.||.|||....| |..|
nrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLTEVQEREQDKCYQYWPTEGS-VTHGEITIEIKNDTLSEAISIRDFLVTlnqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQ
||||||. |... || .|||...  . .|..|......   | .  | .|.        .... . . |... .||. |.|.  . ...|.  |. ..|.
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

TgNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
    ||.|||||| ||||||||| .....|..|  .||. .|. || ||. .||||.||||.|.|. . |
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 131-432 3.9e-84 277.2 In-house 17-314 (315) alignment 
Range on Protein: 131-432
Range on HMM: 17-314/315.0
DCKQFREEFNSLPSGHIQGTfELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATI
    | |||. ||   |  .   | ...| .|||| |||| |..||.|  .| .| ||||||||| .... . .||.|||.. .|.||||||...| .||
htalfseefhdlpdPdiyrq.rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMLTNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpdgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA
||.|...|    || |||||       .|.|.| . .     | ..||. ..       .. | |.| .|| ||| ||.     .||..|.||. |  . 
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk.....seesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

GPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE
 ...||||||||||| .| || ..| .. .. ||||.||  .|..||..|||. .|.|||.|.||. |. .| . |  .  ||| .| ..    .  . .
fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtk

EFRK
||..
efet
subfamily_Ptp69D_pd Subfamily Ptp69D 422-691 4e-84 277.3 In-house 19-287 (307) alignment 
Range on Protein: 422-691
Range on HMM: 19-287/307.0
DK-IGLEEEFRKLTNVrIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH
|   ||..|..|| .   .. . ....   |  | |  .|...| .||.|.   |.|..|||||||| ||..|  ||| |.|.  |..||||||.| ...
dtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQ
.||||....| ...|| .||| |  | .|.| ... .    .   ||.. |. .. .. ..|. | | |.|. ||..  .|   .|...||  |.. ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

TgNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID
  . ||.||||||.||.|.|.||. .|...|||  .|.|. || || ||. .|| ||||.|.|. . |...
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0040439 (Phosphotyrosine protein) phosphatases II 442-689 6.7e-84 276.6 In-house 2-245 (249) alignment 
Range on Protein: 442-689
Range on HMM: 2-245/249.0
NMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP
......||.|..| |   |.|||..||.||  .| . .||||||.||||..|. |||||||| .||||||||.||.....|||||. .|... ||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQT-GNHPITVHCSAGAGRTGTF
..||...|..|.. .. . .. . .| . .| .     .. ..| |.......||. |.|   . ..|.| ||.| ....  ..|. |||||| ||||||
lggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
||.  .||... |. .|...||| || |||..||..|||.|.|......
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 444-690 1e-83 275.8 In-house 2-243 (245) alignment 
Range on Protein: 444-690
Range on HMM: 2-243/245.0
RTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE
....||.|..| |  .|.|||..||.||   |.. .||||||..||||... ||||||||..||||||||.||....|||||||  |... ||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GSVTHGEITIEIKNDTLSEAISIRDFLVTLNqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIAL
.|.|.|..|.. .. .  . . .| . || .     .. ..| |...|...||. |.|   . ..|.. .|.|......|.|. |||||| ||||||||.
esltygdftvtllseehlddytvrtlevtnl.....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

SNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
  .||....|. .....||| || |||..|||..||.|.|.......
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 117-431 1.8e-83 275.4 In-house 7-324 (325) alignment 
Range on Protein: 117-431
Range on HMM: 7-324/325.0
VEHLEEEIRIRSADDCKQFREEFNSLPSGHIQgTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVN
|  | | .  . |.|   |  ||. |||   . ... | | ||..|||..|... |.|||.|  ..  | ||||||||.  .|.|. |.||| |. .|.|
vvnlvehvekkkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMVWEQKsATIVMLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLVDYTIRKFCIQpQLPDGckAPRLVSQLHFTSWPDFGVPFTPIGML
|.||.| . . ...|...|  . ....| .|||..     |.| ..| .     . ||  |.. .. |  .|    | | |... ||.|.||.  |  ..
dlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk.qvkkG..etrsvkqfqlqswddmGvqkrpatli

KFLKKVKTLN-PVHA-----GPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE
 .|. ||...  |.|     .||.|||||||||||.|| . ...| .  | .||.|.|| ..|..||.||.|  ||..||.|| |.|. |.|.. |||.|
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfe

KHLQTMHGTTTHFDKIGLEEEFR
 .| ...      .|. .|.|| 
aklsslqernpltqklniekefe
subfamily_PTPRG_pd Subfamily PTPRG 403-690 9.4e-83 273.3 In-house 2-287 (563) alignment 
Range on Protein: 403-690
Range on HMM: 2-287/563.0
DVSSLEKHLQTMHGTTthfdKIGLEEEFRKLTNVRIMK-ENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYT-DYINASFIDGYRQKDYFIATQ
 |. ..||.  .|  .    .||..||| .|..  | |  .. . . | | .| | ..|..||  || ||   |.. . |||||..||||.... |||||
pvkefakhvaslhadg....digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

GPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQE-EQVRVVRQFHFHGWPEIG
|||..|..|||||||| ....|||.|...||.. || .|||...|.| |.... ...       ..| . .   . .. .. .....|||.|.  ||. |
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

IPAEGkgMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 |     . .|| ...... .     ||.||||||.|||||.|.|. .|.....|   .||. .| .|.||...||| ||| | ...... |
vPehs..lpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
0037934 (Phosphotyrosine protein) phosphatases II 151-395 2.8e-81 267.9 In-house 2-242 (243) alignment 
Range on Protein: 151-395
Range on HMM: 2-242/243.0
FELANKEENREKNRYPNILPNDHSRVILsqlDGipcSDYINASYIDGYkekNKFIAAQGPKQETVND----FWRMVWEQKSATIVMLTNLKERKEEKCHQ
|  |...||..||||..|||.|||||.|   .|   ||||||..|...   ...|| ||| .|||.|    ||||.||... .|||||.|.|.. |||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDQGcwTYGNIRVCVEDCVVLVDYTIRKFCIQPqlPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL--------NPVHAGPIVVHCSAG
|||..   |||...| . .. .| |||.|......  .|  . .||| ..|...|||.||| .|  .|.||..|..         .  . ||..||||||
ywpgev..tygdftvtllseehlddytvrtlllen..ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFIVIDAMMAMMhaeqKVDVFEFVSRIRNQRPQ-MVQTDMQYTFIYQALLEYY
||||||.|... |. ..    .||..| | ..|.|||. .|||  || |.|.||||..
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 441-690 4e-81 267.7 In-house 23-272 (278) alignment 
Range on Protein: 441-690
Range on HMM: 23-272/278.0
ENMRTGNLPANMKKARVIQIIPYDFNRVIlsmkrgqeytDYINASFIDGYrqKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYW
  . ..... |..| |  .|.|||..||.          ||||||.||||  .. |||||||| .||.|||||.||.....||||||..|... ||.|||
seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQArQEEQVRVVRQFHFHGWPEIGIPAEG--KGMIDLIAAVQKQQQ------------QTGNHPI
| .||.|.|..|..... .  . . .|..|||    .  .. . | |...|...||. |.| .   | ...|.  ... ..            . ...|.
peggsltygdftvtllseevlddytlrtllvtnltver.edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

TVHCSAGAGRTGTFIALSNILERVkaEGLLDVFQAVKSLRLQRPH-MVQTLEQYEFCYKVVQDFI
 |||||| |||||..|.  .||..  || .|...||| || |||. .||.||||.|.|.......
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN9_pd Subfamily PTPN9 133-397 9.8e-81 266.0 In-house 16-292 (297) alignment 
Range on Protein: 133-397
Range on HMM: 16-292/297.0
KQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVM
.  ..|.  . .  ..|||. ...  | ||||| ..|  |..|| |...|. ..||||||...||||.|. |||.||| ..||.|||||||||.  .|||
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPdgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLN------
 | . ||.  || ||||  .. .  .|...| . . ..  ||..|.. |.       .  | |.   |.||||.||| .   .|..|.||.         
ttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt...eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

-------PVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLY
       ...  |||||||||.||||||| .|  .. .. ...|||.| |...|.||  ..||. ||.| |.|.||| |.
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 120-394 1.3e-80 265.5 In-house 2-275 (281) alignment 
Range on Protein: 120-394
Range on HMM: 2-275/281.0
LEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFW
|..... .|..| . | ||...| .  .. | . ....||..|||| ||   |..|| ... .    .|||||....|||.....||.|||  .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG-CWTYGNIRVCVEDCVVLVDYTIRKFCIqpQLPdGCkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLK
.||||||  .|||.|.  |    |||.||||.    .||...|  .       |  ||| .  .   ..  .| |.||..|.||| ||| |.  .|.| |
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..ere.sg.etreveqlaytaWPdhGvPattkellefrk

KV-KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAE-QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
.| |. .. .  |.|.|||||||||||.| .| ..  ..|| ...|| . |  .|..|  |||| .||.|.|.|.|..
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 108-406 1.4e-80 265.6 In-house 3-295 (297) alignment 
Range on Protein: 108-406
Range on HMM: 3-295/297.0
GPKKYFPIPVEHLEEEirIRSADDCKQFREEFNSLPSGHIQGTfELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEknKFIAA
.||.  |||. ..     ..   ... |.|||. ||.  || .   |.|  | ||.|| |||| | |||.|  ..  | |||.|||.. |.|.  ..|. 
spkerrpiplsdfatl..vqknrhtdvfseeflclpeaniqpq.tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlitt

QGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEeKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVP
| |...||.|||.||.... .|||||....||.. || .||.|.|  |.|.. | ..       .  |.. ..    .  || |.| | .|..|||  |.
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk...gkakarrvvkqyqfveWPdkave

F--TPIGMLKFLKKVKTLN-PVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDV
   .   .||... |.     .  ||..|||.||||||| .. || ..| .. |..||.|..|...|..||..|||. ||.|.|.|.||. |  ||....
rkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa

SS
| 
sy
subfamily_PTPRK_pd Subfamily PTPRK 443-686 5.4e-80 263.5 In-house 35-273 (314) alignment 
Range on Protein: 443-686
Range on HMM: 35-273/314.0
MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT
  . .   | .| |. .|..||  ||.|    |.  .|||||..||.|..   ||.||||| .||.||||.... .. .||||||..|  . ||..||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

EGSVtHGEITIEIKNDTLSEAISIRDFLVTLnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQtGNHPITVHCSAGAGRTGTFIA
...| .|.| .|. . .| . . .| | |.     ||. |..|.||||.| |||. ..| . .|...|.. |.|.|.. .. .| |||||||||||||||
dtev.ygdikvelvetellaelvvrifrvek...largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfia

LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
.. .|. .. ||..|||.|||.|| ... ||.| ||| |.| |.
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 115-395 1.9e-76 251.7 In-house 2-283 (290) alignment 
Range on Protein: 115-395
Range on HMM: 2-283/290.0
IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIP-C-SDYINASYIDGYKEKNKFIAAQGPKQ
|||... | .    |   ..||..|..| ||. . | . .. ..|...||. ||...|  |..| .. | . |  .||||.||.|||||...||.||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDgcKAPRLVSQLHFTSWPDFG-VPFTPI
.|. |||...|..|.. |||||| .| ...||.|||||..  .||.... . .  .| .|..||. .. .  .  .|.. | |...|.|.. | |. .  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqt

GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 .| . . .||      ..||||||..|||...|....  .  .. |. .|||. . . | |.|..|||  || .|.| .|.| 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 131-395 2.3e-76 251.5 In-house 3-268 (274) alignment 
Range on Protein: 131-395
Range on HMM: 3-268/274.0
DCKQFREEFNSLPSGHIQGTFELANkeeNREKNRYPNILPNDHSRVILSQLDG-IPCSDYINASYIDGYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSA
. |....|| .||. . |   ...    . .|||| .||||..|||.|.. ..  . |.|||| || ||.|..| ..|.||| ..||.|||||...... 
sfkdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevq

TIVMLTNLKERKEEKCHQYWPDQGCW----TYGNIRVCVEDCVVLVDYTIRKFCIQPqlpdgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL-
 |||||.|||..|.||..|.||.       .||.. . ||. |   ||..||. ..      .. .| |    .|.|||  .|  .  .|.....|..  
vivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlky.....lerersvkhywytdWPdhksPddantlldlvleveesr

--NPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
  .  ...|.|||||||.|||| || |.  .  ...|..|||.. |. .| .|  ||||. || .|..|| .| 
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 422-699 6.3e-76 250.1 In-house 18-287 (287) alignment 
Range on Protein: 422-699
Range on HMM: 18-287/287.0
DKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSmkrgQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHT
 . | .. |  | .|   ....  .  . | .| |. ||...| .||.|     .|  |||||.|||||..|  ||....|...|. .||..|.. . ..
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQT
||||.. .| ....||||||.| ||. || .||. |.. ..   .|.. |. ..    .... . |.|...  |.. |  .| . .. .|    |.|.. 
ivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn....kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

GNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANF
|| .| ||||.. ||...|.|    ....| || .|||| .|| | |.|..||| |||.| ...|. ..| |. |..|
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPN12_pd Subfamily PTPN12 152-394 8.9e-76 249.5 In-house 33-276 (290) alignment 
Range on Protein: 152-394
Range on HMM: 33-276/290.0
ELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ
| ..||||..|||| .||| |.||| ||. .. . ||||||..| | ..| ..||||||  .|..|||||.||..   .||. .. | .  ||..|||..
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

G--CWTYGNIRVCVEDCVVLV-DYTIRKFCIQPQlpdgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVI
|    ..|...| .|.   .  |..|| . .. |     |. | | |.|.|.||| ||| ..  .|.....|..|.  .. |.||||||||||||| |.|
geeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DAMMAMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
| .  ...||.    .|||. | ..|.||. .|||  ||...|.|..|.
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN9_pd Subfamily PTPN9 419-690 1.4e-75 249.0 In-house 11-290 (297) alignment 
Range on Protein: 419-690
Range on HMM: 11-290/297.0
THFDKIGLEEEFRKLTNVRIMkENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWK
 . .| || .|. .. |  .   .. . .|.||..| |   .. ||  || |. . ..|..|||||.|.|||.||. |||||||| .||.|||||.|| .
kekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

SHTIVMLTEVQEREQDKCYQYWP--TEGSVTHGEITIEIKNDTLSEAISIRDFLVtlnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK
  .||| | | || . || ||||  .| |  .|.....  ..  .|.  .| . .     .  ..|. | |  | | .||. |.| ... ..|.. .|..
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei.....knvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

QQQQ------------TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
.| .            . . || |||||| |||||||.|   |.|.. .| .||...|| || || ...|| |||||||. | .. 
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN6_pd Subfamily PTPN6 404-692 1.5e-75 249.1 In-house 6-299 (306) alignment 
Range on Protein: 404-692
Range on HMM: 6-299/306.0
VSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKE-NMRTGNLPANMKKARVIQIIPYDFNRVILSmKRGQEYTDYINASFIDGY--RQKDYFIATQ
 ...|.. . .. ......| |.|||| .| .   .|  . . |. | |..| |   |.|.| .||||. . .   .|||||..|..    .. ..||||
akeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatq

GPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV-THGEITIEIKNDTLSEAISIRDFLVTLNqpqaRQEEQVRVVRQFHFHGWPEIG
| | .||.|||||.|. .|. |||.|.  || ..||..|||.| .  ..|.|...  ...  ..  .|...|. .    ..... | |.|.||. ||. |
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk....kkkkeerevfqyhfksWPdhg

IPAEGKGMIDLIAAVQKQQQQTG---NHPITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDI
.|.. . ..|..  |...|...    . || |||||| ||||||| .  .|. .. .||   .|. ..|||.| ||  .||| .|| | ||... .|. 
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 129-417 1.4e-74 246.1 In-house 16-301 (439) alignment 
Range on Protein: 129-417
Range on HMM: 16-301/439.0
ADDCKQFREEFNSLPSGHIQ--GTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQK
 .. . |.|.|... | . .      || .| .. |||| .. . ||.||.| .. |.| | |||| ||.|| ... .||.||||.||..||||.|.|.|
knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

SATIVMLTNLKERKEekchqYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV
..|||||||| |        ||| ..   ||.| | |.  . | .|.|| | .  .  | ..  | | |.|...|||  ||     .|.||. ... |  
tvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfner.dttekertvlqfhyiawpdknvpaqashvldflrainsandk

-HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGT
   ||.||||||||||||| | .|  .  ...|.|||.   |. .|.|| ||||.  || |||.|.||   |||. . .  ..|....   |
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefnagfst
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 445-687 1.9e-74 245.5 In-house 43-277 (315) alignment 
Range on Protein: 445-687
Range on HMM: 43-277/315.0
TGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEg
. .   | .| | |.||.||  || | .   .. .||.||.||||| .|. .||.|||.. .|.||||...| .  .|||||.. |.|. |. .||| . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

SVTHGEITIEIKNDTLSEAISIRDFlvtlnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGnHPITVHCSAGAGRTGTFIALS
 |..|.||.  |..   . ...| .           ....| | |.|.  ||..|.|.    ...||  |.. ....   .| |||||| |||||||.|.
kviyGkitvtrkseevnteytvrtl.......svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitld

NILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV-Q
 .|....|| ..||..... .| .| .|||..|||.| |... .
avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 424-696 2.4e-74 244.8 In-house 20-289 (290) alignment 
Range on Protein: 424-696
Range on HMM: 20-289/290.0
IGLEEEFRKLTNvRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEY--TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHT
 | ...| .| .    .... .|. . | .. |  .|..|| ||..|  . |..    .||||..|.||..|  .||||||. .|. |||..||. |.  
egfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvti

IVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQarqeEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQT
|||||...| ...||.||||.... . ||..|.. |..  . . .| . |. .. .    .. . | |...  |.. |  .. .... .|. ..|.| ..
ivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa....gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

GNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDY
||..| ||||.. ||...|.|. . ....| ||  |||| .||.| |.| .||| .||.. ...|   .| |. |
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN12_pd Subfamily PTPN12 442-690 2.8e-74 244.6 In-house 31-277 (290) alignment 
Range on Protein: 442-690
Range on HMM: 31-277/290.0
NMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP
.  .|. . |.|| |   |.|||..|| || ....|  |||||.|| |  .|  .||.||||..|..|||||||| . . .||. .. | .. || .|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

TEGS--VTHGEITIEIKNDTLSEaisiRDFLVTLNqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQqTGNHPITVHCSAGAGRTGT
 ||   ...||.... ...   .     |||.     ....... |.|.|||.. ||. |.|.  | ...||..|.. |. . ..|. |||||| |||||
eegeeelefgefevtleeekavd....ddflirtL..kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGt

FIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 ||.  . | .||| .   ||||. | .|| ||. .||| ||||. || | ...
iiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 419-691 5.8e-74 243.7 In-house 10-277 (281) alignment 
Range on Protein: 419-691
Range on HMM: 10-277/281.0
THFDKIGLEEEFRKLTNVRIMkENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWK
.. |. |. ||..||... .  .  .  . ..|..| | . |. ||  || .. .  .. ||||||.|..||...  .||||||. .....||.|.|| |
sqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

SHTIVMLTEVQEREQDKCYQYWPTEG-SVTHGEITIEIKNDTLSEAISIRDFLVtlNqpqaRQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQ
 ..|||.|.  | .. ||..||| .  ... |..|.. .. . ..    | | .  .    |.. . | |.|...  ||. |.||. | ...  ..|.| 
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..e....resgetreveqlaytaWPdhGvPattkellefrkevlkl

QQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID
...  ..|. .||||| |||||.|||  ....|.||   ||| . |..|| .|  ||||. |||| ||.| | .|
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0037934 (Phosphotyrosine protein) phosphatases II 443-689 6.4e-73 240.6 In-house 2-241 (243) alignment 
Range on Protein: 443-689
Range on HMM: 2-241/243.0
MRTGNLPANMKKARVIQIIPYDFNRVILsmkrgQEyTDYINASFIDGYrqkDYFIATQGPLAHTVED----FWRMIWEWKSHTIVMLTEVQEREQDKCYQ
.....||.|..| |.  |.|||..||.|     .  .|||||..|...   ...||||||| .||||    ||||.||.....|||||| .|... ||.|
fsiallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPteGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQeeqvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQ-------TGNHPITVHCS
|||  |.||.|..|..... .  . . .| .|..  ...  .    | |...|...||. |.| . . ..|.. .|.. ...        ...|. ||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt....rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGAGRTGTFIALSNILERVkaeGlLDVFQAVKSLRLQRPH-MVQTLEQYEFCYKVVQDF
|| |||||.||.  .|...   | .|...||| || |||. .|||..||.|.|.... .
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 115-400 4.8e-72 237.4 In-house 2-283 (287) alignment 
Range on Protein: 115-400
Range on HMM: 2-283/287.0
IPVEHLEEEIRIRSADDCKQFREEFNSLPS-GHIQGTFELANKEENREKNRYPNILPNDHSRVILSqldgIPCSDYINASYIDGYKEKNKFIAAQGPKQE
||||.. | ..   |   ..|.. |  | . .. .     .  ..|..|||. .||. |  ||.|         |||||..|||||||..||.|..|  .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGckAPRLVSQLHFTSWPDFG-VPFTPIG
|. .||.......  .||||...|| .||.|.||||.. . ..|. .. . .  |  .|..||. .. .  .|  ... | | ..|.|.. | |.     
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkag..dkqqvkqyqitnWdstgkvtepqti

MLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT
.| . ...||      ..||||||..|||...|. ..  .   . |  .|||. . . | |.|..|||  ||.||....|||   ..|
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_PTPN3_pd Subfamily PTPN3 150-395 7.4e-72 236.6 In-house 32-275 (280) alignment 
Range on Protein: 150-395
Range on HMM: 32-275/280.0
TFELANKEENREKNRYPNILPNDHSRVILSQLDgipCsDYINASYID----GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCH
. . |.| || .|||| .||| |. ||.|.. .     |||||.|..    . .  |..||.||| ..|..|||.||||||| .|||||.| ||   |||
aisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPDQG-CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGT
||||...  ..||...| .| .     | .|..... .     |  | . || ...||| |||  .  .|.|...|..|  ..  |.|||||||.|||| 
qyWPetedeleygefsvkcekedetksyvlrelvlkdk...etkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGv

FIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
.|...  .|.. |...| . . |...|.||  .|||  ||.|. .|.|. |
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 127-417 7.7e-72 236.8 In-house 14-258 (392) alignment 
Range on Protein: 127-417
Range on HMM: 14-258/392.0
RSADDCKQFREEFNSLPSGHIQGTfELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQK
     .  | |||  ||. .|  .   |.|| | .|||| |||| | .||.|  .| || |||.|||||.... .. .||.|||.  ...||||||....
eknrhsalffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqen

SATIVMLTNLKERKeekchqywpdqgcwtygnirvcvedcvvlvdytirkfciqpqlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV
 .||.|.|.|||                                                 .  | |.| ||| ||| .||     .|||.|.||.    
vttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGT
.. |...||||||||||  | ||...|  .  . ||||.||. ||..|| ||||. ||.||| |.||  |. .| . |  .  |||... .
ythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts
subfamily_PTPN13_pd Subfamily PTPN13 129-393 2.7e-71 235.0 In-house 7-267 (273) alignment 
Range on Protein: 129-393
Range on HMM: 7-267/273.0
ADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGipcsdYINASYIDGYK--EKNKFIAAQGPKQETVNDFWRMVWEQK
. | .|  |||. |   . . | | ..|.||..|||| |.|| |..||.|..  |     |||||.|      .. ..||.|||  |||.|||.||||||
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

SATIVMLTNLKERKEEKCHQYWPDQG---CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTL
.  |.|.|. ||... |||.|||..       .. ..| ... . | ....|.. .. .     .. | |..|.|..||| ||| ..  .|.|...|..|
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds...esgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

NPvHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
.  .|||||||||||.||.||.|.||... ... ....|| | | ..|.||  .|||. || |.|.|.||
qt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 153-393 2.9e-70 231.1 In-house 2-239 (239) alignment 
Range on Protein: 153-393
Range on HMM: 2-239/239.0
LANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ
 |.|  |. |||| ||.  |||||.| .|   | ||||||||.  |    | .||.||  . .  |||||.|... . ||||| | | ...|||||||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GCwTYGNIRVCVEDCVVLVDYTIRKFCIQpQLpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM
    | |.|| .    |. || || | .  |.  |    | | | ||| ||| |||     .| . .|.   .   | | |.||||||||||.|.|||||
ts.kycnlrvtlrktevfadyiirtfvms.qv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
.   . .. ||.|..|  ||..||.||||  || ||. |.||
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 154-393 4.3e-70 230.6 In-house 2-238 (239) alignment 
Range on Protein: 154-393
Range on HMM: 2-238/239.0
ANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNK-FIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG
|.|  |. |||| ||.  |||||.| .|   | ||||||||.  |    | .||.||  . .  |||||.|... . ||||| | | ...||||||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

CwTYGNIRVCVEDCVVLVDYTIRKFCIQpQLpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMM
   | |.|| .    |. || || | .  |.  |    | | | ||| ||| |||     .| . .|.   .   | | |.||||||||||.|.|||||.
s.kycnlrvtlrktevfadyiirtfvms.qv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

AMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
   . .. ||.|..|  ||..||.||||  || ||. |.||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 158-393 7e-70 229.9 In-house 2-237 (237) alignment 
Range on Protein: 158-393
Range on HMM: 2-237/237.0
ENREKNRYPNILPNDHSRVILSQLDGIpcSDYINASYIDGYKEK-NKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG-CWT
||. |||| ||   |||||.|    .   ||||||.|..|.    .|.|||||| . . .|||.|||..| . ||||| | |..|.|||.|||.     .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGNIRVCVEDCVVLVDYTIRKFCIQPQLPdgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMA
|| . | .     . |||.| . .. .|    |  ||. | .|||||| |||     .|.| |..   .|   ..|| ..|||||||||| |.|||||. 
ygvltvslkkkeefsdytvrslllskrlt..lkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
  . .. ||....|  | ..|| ..||  || ||.|..||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_CG7180_pd Subfamily CG7180 149-398 9.3e-69 226.3 In-house 32-293 (296) alignment 
Range on Protein: 149-398
Range on HMM: 32-293/296.0
GTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEeKCHQYW
|.   . ..|||||||.....| |. ||.|..|||   ||||||.|.|..  |...|  ..||.|||..|||.|..... ..|.||.  . .. ....||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQ------LPDGCKAP-RLVSQLHFTSWPD-FGVPFTPIGMLKFLKKVKTLNPV-----HAGPIVVHC
| ..   ||.| | .     . . .||.| .. .         . ||. |.| ....| |.    ||.   ........|...        . ||.||..
pnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYG
| |..|.| .. ||| . ... |..|||||.| ..|..|||.|..  .| .||. |||..| .
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_CG7180_pd Subfamily CG7180 434-690 1.5e-68 225.7 In-house 25-290 (296) alignment 
Range on Protein: 434-690
Range on HMM: 25-290/296.0
TNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ
.  |.  .. ..|    |..| | ....|||.|||.|.   |.| .|||||...|.. .|  .| |..|  .||..|||.... .....|.||.. . ..
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

dKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLN-----QPQARQEEQVRVVRQFHFHGWPE-IGIPAEGKGMIDLIAAVQKQQQQT----GN
 .. .||| ..   .||| .|| .     .. || | .| .     . ..  . ..|.|..|..  |.    .|   ...|.|.  |.. ....     .
.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

HPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 |. |..| ||.|.| ..|.   || |. |. .|||.||| || .||..|.. |.| ..| |.....
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 427-689 2.5e-68 225.3 In-house 22-276 (315) alignment 
Range on Protein: 427-689
Range on HMM: 22-276/315.0
EEEFRKLTNVRIMKEnmRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT
 |||. | .  | ..  |..  . |.|| |   |.|.| .||.| .   .   ||||||.| .. .   .||.||||  .|.|||||... |  ||||.|
seefhdlpdPdiyrq..rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

EVQEREQDKCYQYWPT--EGSVTHGEITIEIKNDTLSEAISIRDFlVTlnqpqaRQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQqQQTGNH
. || .. || ||||     ||  |.| .|. .        .| . ||      |. |. | | ||.|..||. |.. .   .. || .|. . ... ..
kkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt......rkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkef

PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
.. ||||||.|||| .|.. ......| .  .|||. || || .||..||| |.| | | .|.. 
sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 428-689 7e-68 223.9 In-house 30-283 (297) alignment 
Range on Protein: 428-689
Range on HMM: 30-283/297.0
EEFRKLTNVRIMKENMrtGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQkdYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE
|||. | .  |... .   .   |..| |   |.|||..||.| .   .   ||.||||. |...   .|.|| |   ||.|||.|... .  |||||..
eeflclpeaniqpqtv..aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnd

VQEREQdKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARqeeqvRVVRQFHFHGWPEIGIPA--EGKGMIDLIAAVQKQQQQTGNHP
 .||.. || .||. .|..| |.......  .  |  . |.. || ....||     |||.|..|  ||.  ..   . . ...||  |.|. .|. . |
dnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar.....rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegP

ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
. |||.|| |||| .... ... ..| |  .|.|. || || .||..||| |||.| |..| ..
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 152-395 1e-67 223.0 In-house 13-264 (270) alignment 
Range on Protein: 152-395
Range on HMM: 13-264/270.0
ELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKE-KNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD
.| .   ... ||| .|||. ..||.|..|.  . . |||| |. |... |.|.|||.||.. |...||||.||.|. .|||.|.|.|.  .|| .||| 
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

QG----CWTYGNIRVCVEDCVVLVDYTIRKFCIQpqlpDGCKAPRLVsQLHFTSWPDFGVPFTPI------GMLKFLKKVKTLNPVH--AGPIVVHCSAG
.       ..|.|.|...  .    | ...  ..    .  .  |||   ....||| ||| ..        .|| |..|.  .  .  |.|..||||||
epkekvkledgkikvlalseekeegyiltrlrle....ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

VGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
||||||.|..| .. ... ..|||| . ....|..|...||.  ||.|.|.|..|| 
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 427-689 5.6e-67 221.0 In-house 21-275 (515) alignment 
Range on Protein: 427-689
Range on HMM: 21-275/515.0
EEEFRKLTNVRIMKENMRTGNLpaNMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT
 |||. |    |  . .   ..  | || |   |.||| .||.| .   .   ||.|||.| ..     .||.|||.  .|.||||.... .  ||.|.|
seefhdlpgpniypqtvaqeei..nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

EVQEREQDKCYQYWPT--EGSVTHGEITIEIKNDTLSEAISIRDFLVTlnqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGnH
. .| .. || .|||     ||  |.| .|.          .| . |.       .....| | ||||..||. |.| . . .. || .|. ...|   |
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl.......kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.h

PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
|. .|||||.|||| .|.. ... ..|    .|||. |. .| .||..||| ||| | | .|.. 
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 415-698 3.6e-66 217.9 In-house 8-301 (301) alignment 
Range on Protein: 415-698
Range on HMM: 8-301/301.0
HGTTTHFDKigLEEEFRKLTNVRIMKENMrtGNLPANMKKARVIQIIPYDFNRVILSMKRG--QEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR
| ...| .|  .||....|....  . ..  |   .| . .|  .| .|| ||.||. |.   .  ..|||||.||||..|  |||.|||. .|. ||||
hvaakhsnk..feeqykelkegedksctv..glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

MIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQA----------RQEEQVRVVRQFHFHGWPEIGI
.||. |  .|||.|. .|. ..||.||||.  . | . |..|....|..      ||.. |....             ... . . | |..   ||. |.
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

PAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYAN
  | . ..  |  | ..||. |  |. ||||.. .|.|.....|  || .||||  |||| .|..| ..| .|.||||| . |.|.. .. . | |||
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 442-689 4.2e-66 217.9 In-house 19-267 (274) alignment 
Range on Protein: 442-689
Range on HMM: 19-267/274.0
NMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEY-TDYINASFIDGYRQK-DYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQY
...  ... . .| |  .|.| .  ||.|. . ...  ..|||| .| ||...   ..||||||..||.||||||.. ... |||||...|....|| .|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPTEGSV----THGEITIEIKNDTLSEAISIRDFLVTLNQPqARQeeqvrvVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNH--PITVHCSAG
.|.. ..    ..|.. |.... .  .  |.| ...   .   |.      |  . .  ||.   | . . ..||.. |....... ..  |. ||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler.ers......vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

AGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
 |||| ||| |. . ....|. .||.. |  |||.|  |||| ||||. ....  .
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_PTPN23_pd Subfamily PTPN23 128-394 2e-65 215.5 In-house 10-279 (288) alignment 
Range on Protein: 128-394
Range on HMM: 10-279/288.0
SADDCKQFREEFNSLPSGHI--QGTFELANKEENREKNRYPNILPNDHSRVILSqldgIPCSDYINASYIDGYKEK-NKFIAAQGPKQETVNDFWRMVWE
  |.  .. ..|. | . .   .  . .|  . . ||||. .||| ||.|| |         ||||||.. .      .|||.|.|.|.|.||||.||.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

QKSATIVMLTNLKERKEEKCHQYWPDQG--CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDgckAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT
||| .||||.. .|....|...||| .     ..|...| ...   .  .  |.. .. . .|   | . || |..||||..||| .|  .|.||..|..
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad...avksvshlqltsWpelGvPasPetllqfldeves

L-----NPVHAgPIVVHCSAGVGRTGTFIVIDAMMAMM-HAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
      ..... |.||||||||||||.| .. | .. . . .  .|. . |||.|.||  |||.  |. | |.| ||.
ayeavqrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 445-688 7e-65 214.3 In-house 42-286 (325) alignment 
Range on Protein: 445-688
Range on HMM: 42-286/325.0
TGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVqEREQDKCYQYWPTE-
.  .|.|..| |   ....| .||.|  |. .  .||||||..  ...|| |.|.| ||..|..|.||.. .|..  .|.| |. . ..|.| .||| | 
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkem

-GSVTHGEITIEIKNdtlSEAIsiRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQ---Q--QTGNHPITVHCSAGAGRT
  |.| | . ....     | |   |..    . .  .. . | |.||.. .|...| .     .| ..  |.. .   .    .  || |||||| |||
gksktfGglevklrt...ieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

GTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
|.||.|  .|..|  |  .|.|. || || .|| ||.| .|| ..|. . .
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 130-405 3.7e-64 211.3 In-house 6-276 (283) alignment 
Range on Protein: 130-405
Range on HMM: 6-276/283.0
DDCKQFREEFNSLPSGHIQGtfELANKEENREKNRYPNILPNDHSRVILSQLDGipcsDYINASYID---GYKEKNKFIAAQGPKQETVNDFWRMVWEQK
.. | ||| .. |   . .   ..|  .||..|||. .|.| |  || |  .      |||||..|     ||...|.|.||.| ..|| |||.||...|
nnnklfrevlkrlsvpdlda..diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

SATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGCKAPRLVSQLHFTSWPDFGvPFTPIGMLKFLKKVKTLNPV
 ..|||||.|.| ...|| |||| .|   ||.  | ... .    ..|... .. .    .|.  |..   .  | ..| . ..|  |  . ||..|   
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..ssakstlllahyqvidWleyg.eqaiinslvkfnkvislqte

H-AGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVS
.  ||||||||.|.|||..|| . | .  . .|  ||||. |  .|.||. .|||  || ..... ||  | |||..   
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaav
subfamily_PTPN1_pd Subfamily PTPN1 152-402 6.3e-64 210.5 In-house 25-280 (290) alignment 
Range on Protein: 152-402
Range on HMM: 25-280/290.0
ELANKEENREKNRYPNILPNDHSRVILSQLDGipcsDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP-D
. |...|||..||| .. | ||||..| . |     |||||| ..  . | ..| .|||  .||. ||.||||||| ..||| .. |... ||.|||| .
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

Q--GCWTYGNIRVCVED--CVVLVDYTIRKFCIQPqlpDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGT
.   . .. .... |.     .   ||.|.. ..      ..  | ... |.|.||||||| .|  .|||| ||.    .  . || |.|||||.||.||
eeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FIVIDAMMAMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE--YYLYGDTEL
|...|.... ......   ||. . .  .|..|  ..||  |  | |.|.||    . ||. .
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 430-686 9e-64 210.1 In-house 12-262 (283) alignment 
Range on Protein: 430-686
Range on HMM: 12-262/283.0
FRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGqeytDYINASFID---GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT
. .| .. . . .        | .| |  .|.|.| .|| |  .      |||||.||     |.|.  .|..|.|| .|| |||.|... |  .|||||
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

EVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNqpQARQEEQVrvVRQFHFHGWPEIGIPAEGKGMIDLiAAVQKQQQQTGNHPI
..|| .. || |||| .||. .|| |. ....| |.. .|. .|.  |   . ... .  .  . . .| |.|  |    .. .   |. .|..  . ||
klqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..ssakstll..lahyqvidWleygeqaiinslvkf.nkvislqteskkgPi

TVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
 ||||.| |||..|||.|  .. ...| ..|||. || .| ||. .||||.|| . ...|
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN23_pd Subfamily PTPN23 422-686 5e-63 207.6 In-house 13-276 (288) alignment 
Range on Protein: 422-686
Range on HMM: 13-276/288.0
DKIGLEEEFRKLTNVRIMKENMRTGN-LPANMKKARVIQIIPYDFNRVILSmkrgQEYTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKS
.| .|...|..|..    . . |.      . .| |   |.||| ||| |     ..  |||||||. .       |||||.||. |. |||.|..| ||
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

HTIVMLTEVQEREQDKCYQYWPTEG--SVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK-
 .||||.. .|... |. .|||..   .|..|.... .|. . .|  . |.. .. ..     ...|. |.  ... |||.|.||  . ..... .|.. 
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.....adavksvshlqltsWpelGvPasPetllqfldevesa

--QQQQTGNHPITVHCSAGAGRTGTFIA-LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
  ..|.  . |. |||||| ||||.|    . . |  | .||||. | |. || || .|||. ||..|.|..|
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN13_pd Subfamily PTPN13 421-687 1.9e-62 206.0 In-house 8-266 (273) alignment 
Range on Protein: 421-687
Range on HMM: 8-266/273.0
FDKIGLEEEFRKLTNVRIMkENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGqeytdYINASFIDGYRQKDYF--IATQGPLAHTVEDFWRMIWEWK
.|.   .|||..| ... . .. ..|.  .|..| |  ...|||  ||.|. . |     |||||.|    .|| .  ||.|||| .||.|||.|.|| |
ldqqqPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

SHTIVMLTEVQEREQDKCYQYWPTEGS--VT-HGEITIEIKNDTLSEAISIRDFLVTlnqpqARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQ
.. |.|.|  .|... || .||| . .  .. .. ...|  . .  .. ..|.. |.       . ...| | ...|  ||. |.|.. . .. ..| |.
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.....dsesgesrevahlnfvkwPdhgvPssaaellqfvaevr

KQQQqtGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQ
. |.   . || |||||| ||.||.|..  .|. .. .  .|| . |..|| ||  .||| .|| |.||.. 
rlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 130-396 2.1e-62 205.5 In-house 12-294 (301) alignment 
Range on Protein: 130-396
Range on HMM: 12-294/301.0
DDCKQFREEFNSLPSGHIQgTFELANKEENREKNRYPNILPNDHSRVILSQLDG--IPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS
   ..| |....| .|. . . ..  .|||.. ||. || . |. |.||..     .   .||||||||||.||.|||||||| ..|. ||||..|..| 
khsnkfeeqykelkegedk.sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

ATIVMLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLVDYTIRKFCIQpqLPDGCK--------------APRLVSQLHFTSWPDFGVPFTPI
..|||.|||||....||.||||.      ..|.. | . .  |. |..||.....  . || .              ... | ||. |.||. ||   | 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvk..iqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

GMLKFLKKV-KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
 .|. . .| .. . .  ||.|||||..|.|.|... ..  .    ||  ||||. . ..| ..| .|.|  |||.||... .|  
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0051429 (Phosphotyrosine protein) phosphatases II 184-429 5.7e-62 205.0 In-house 1-262 (272) alignment 
Range on Protein: 184-429
Range on HMM: 1-262/272.0
IPCSDYINASYIDGYKE---KNKFIAAQGPKQETVNDFWRMvWEQKSATIVMLTNLKERKEEKCHQYWP------------DQGCWTYGNIRVCVEDCVV
.| |.||||....||     ........|| . |..||||. .|..  |||.|... ||. .||..|||            .    .||..||..  ...
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LVDYTIRKFCIQPQLPDGCKapRLVSQLHFTSWPDFGVPFTPigMLKFLKKVKTlnpvhAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVD------
| ||..|....  .|. |    | | .||.|.|||.|||  .  .|..|. . .      ||..||||||..||||..... ... ...|. ||      
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYyLYGDTELDVSSLEKHLQTMH----GTTTHFDKIGLEEE
  ..|.|...| |||..|||..|| |.|.||||. |.. .. ... |. .|....    .. ... ..||.||
lyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaideeyGsvegYLrdlglsee
subfamily_PTPN14_pd Subfamily PTPN14 136-394 3.3e-61 201.9 In-house 26-295 (300) alignment 
Range on Protein: 136-394
Range on HMM: 26-295/300.0
REEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIpCSDYINASYIDGY--KEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML
  |.. .|  . ..... |. .|| ||||....|| ...|| ||       ..||||| |      .. ..|.|||| . ||.|||.|||||. . ||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TNLKERKEEKCHQYWPDQ----GCWTYGNIRVCVEDCVVLVDYTIRKFCIQpQLPdgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPV---
|. .|   ||...|.|..       ..|. .|  .       .. ... ..  ||   |  | |  | .| ||| |||  . |.|..|..|. .      
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklk.hlp..skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

------HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
      .  |..|||||||||||  |. | ..| .. ....|. . ..|.|.||  .|||  ||.|.|..|..|
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPRN_pd Subfamily PTPRN 149-393 1.3e-60 199.6 In-house 46-290 (297) alignment 
Range on Protein: 149-393
Range on HMM: 46-290/297.0
GTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYK-EKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQY
 | |.|..|.| .|||. ..|| ||||| |..      ||||||| |      .  .||.|||  .|| |||.||||| .. ||.||.|.|   ..|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPDQGCWTYGNIRVC-VEDCVVLVDYTIRKFCIQPQlpdGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFI
|||.|  .|.   |  | . .   || .| | ..       .  | |.|.|| |||. ||| ..  .|.| .||       . |||||||.|.||||..|
wpdeGsevyhiyevhlvsehiwcddylvrsfylknl...qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

VIDAMMA-MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
.|| ... ...  ...|.   .  .|.|||..|.|  |. |...|. |
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN3_pd Subfamily PTPN3 442-686 1.5e-60 199.5 In-house 32-272 (280) alignment 
Range on Protein: 442-686
Range on HMM: 32-272/280.0
NMRTGNLPANMKKARVIQIIPYDFNRVILSmkrgQEYTDYINASFID----GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCY
.. . ..|.|..| |   |.|||  ||.|.    .. ||||||....    .  .   .||||||||.|..|||.|.|| ||..|||||.. || . ||.
aisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPTE-GSVTHGEITIEIKNDTLSEAISIRDFLVTlnqpqARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGR
||||..  ....||........  .... .|.....      ..... | . |. .  ||. |.| . . .....  |.|.. .. ..|. |||||| ||
qyWPetedeleygefsvkcekedetksyvlrelvlk.....dketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGigr

TGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFC-YKVV
|| .|.|   |  . |.  . . . |. .| ||  .||| .||.|    ..
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPRN_pd Subfamily PTPRN 403-688 2.5e-60 198.7 In-house 10-290 (297) alignment 
Range on Protein: 403-688
Range on HMM: 10-290/297.0
DVSSLEKHLQTMHGTTTHfdKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFI-DGYRQKDYFIATQG
|.|.    |. ..   ..  |  ||.|.  |.. .  ..   ... . |.|| |. ...||| .|| |. .  .| .||||||.| |   ..  .|||||
distGhvvlsyledhlkn..kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqg

PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIkndtLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIP
|||.|| |||.|.||  .  ||.||...| .  .|..||| ||| ...   ...    .|| |   |.||     .  | .. | | ||||  ||| |.|
plastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhl....vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvP

AEGKGMIDLIAAVQKQQQQtGNHPITVHCSAGAGRTGTFIALSNILERV-KAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
|. | ....   |.|  .     || ||||.||||||..|..  .|.|. |    .|.  ... || |||..|.| .|.||....| .
asaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 144-395 6e-60 197.5 In-house 23-277 (287) alignment 
Range on Protein: 144-395
Range on HMM: 23-277/287.0
SGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQlDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEK
|     ||  |..  . .|||| ..|| |..||.||. .|   |||||| |. .|.....|||||||   ||.||||.|.|..||.....|   |    |
sesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

CHQYWPDQGC-WTYGNIRVC-VEDCVVLVDYTIRKFCIQPQlpDgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVK-----TLNPVHAGPIVVHCS
|..|||..      |   |  ..  .   .|..| . .     .  .  |.| ||.. |||| ... | .|...|  .||     . .   .||.|||..
cykywPerevPmrvGGysvvlldydikePeygvralrlidl..e.trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

AGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
.|.||.|... . ... ..    .|||   | |.|..|  .||. .|. ..|.||  ||
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 438-692 1.1e-58 193.4 In-house 4-266 (270) alignment 
Range on Protein: 438-692
Range on HMM: 4-266/270.0
IMKENMRTGNLPANM---KKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ
. ||.. . .||.     |  |  .|.|    ||.|.  . .. | |||| .. |. . | ..||..|||. |...||||||| |...|||.|...|. .
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

DKCYQYWPTEGSVTHGEITIEIKNDTLSEAiSIRDFLVTLNQPQaRQEEQVRVVrQFHFHGWPEIGIPAEGK------GMIDLIAAVQKQQQQTGN-HPI
.|| .|||.|   .    . .||  .|||.   . ...|  . . .. |. |.|  |... ||. |.| |         .. ...||....... . .|.
kkCerYWpaepkekvkledgkikvlalsee.keegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

TVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDI
 |||||| |||||.|||  ... .. .. .|| . .. || .|. .||. ||||| ||.|. ... 
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0041856 (Phosphotyrosine protein) phosphatases II 159-401 4.3e-58 191.2 In-house 1-177 (182) alignment 
Range on Protein: 159-401
Range on HMM: 1-177/182.0
NREKNRYPNILPNDHSRvilsqldgipCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTnlkerkeekCHQYWPDQGcwtygn
|..||||..|||.||||           .|||||....|.   ..|||.||| ..||.||.||..|..  |||.||         ...|||.        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

irvcvedcvvlvdytirkfciqpqlpdgckaPRLVSQLHFTSWPDFGVPFtPIGMLKFLKKVKTlnpvHAGPIVVHCSAGVGRTGTFIVIDAMMAMmhae
                               .||. |.....|||.|||  .  .|.|...|.     . ||..||||||||||||..... |. .    
...............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

qKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTE
 .|...| |. .|..||.||.|  || |...||||..|...|.
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 453-689 5.4e-56 184.9 In-house 50-278 (439) alignment 
Range on Protein: 453-689
Range on HMM: 50-278/439.0
KKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEreqdkCYQYWPTEGSVTHGEIT
 | |  .. ..|. ||.|    |  .. |||| .|.|| ... .||||||  .|..||||...| |. ||||||.. |      |.|||... | .|.|.
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsdaevcygdia

IEIKNDTLSEAISIRDFLVTLNQPQARQEeqvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKA
. .  .       || | |  .. ....|   | | |||.  ||.  .||.   ..|.. |..  ...    |. |||||| ||||| |||   ||..|.
vrvdrnielpnyvirgfkvfnerdtteke...rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
|  .|.   || || || .|||.| || | |. | . 
enkvdikgivkvlrkqrkqmvqalcqyvfiynavled
0051429 (Phosphotyrosine protein) phosphatases II 478-693 1.2e-55 184.3 In-house 3-228 (272) alignment 
Range on Protein: 478-693
Range on HMM: 3-228/272.0
YTDYINASFIDGYRQ---KDYFIATQGPLAHTVEDFWRMiWEWKSHTIVMLTEVQEREQDKCYQYWP------------TEGSVTHGEITIEIKNDTLSE
...||||....|| .   ........||| .|..||||. .|.. .|||.|... ||...||..|||            .. ....| ... .   .| .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

AISIRDFLVTLNQPQARQeeqvRVVRQFHFHGWPEIGIPAEGkgMIDLIAAVQKqqqqtgNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLD-----
 . .| .|.||  .        | |...|...||  |.| |   ...|......      ..|. |||||| .||||..||  .|..| .|  .|     
dyilrellltlllsagea....revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIF
   ...||. || |||..||| |||.|.|........ .
nlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPN14_pd Subfamily PTPN14 428-690 7.3e-55 181.1 In-house 27-296 (300) alignment 
Range on Protein: 428-690
Range on HMM: 27-296/300.0
EEFRKLTNVRImKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQeYTDYINASFIDGY--RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVML
 |. .... |  . .. |..|| | .| |. ...||. ||| ||  . .  |.||||| |      ..  .|..|||| .||.|||.|.|| . . ||||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TEVQEREQDKCYQYWPTE----GSVTHGEITIEIKNDTLSEAISIRDFlvTLNQPQARQEeqvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQK---QQ
|| .|  ..|...|.| .     .|..|.  .  |  . |...  . .  .|.   ...|   | |  . .  ||. |.| . ||... .  ||    . 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl..klkhlpskee...rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

QQT-----GNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
...      . |. ||||||.||||  |    ... .. .  .|. .... || || ..|||| ||.| |||.  ..
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0036282 (Phosphotyrosine protein) phosphatases II 479-684 1.1e-52 173.5 In-house 2-164 (174) alignment 
Range on Protein: 479-684
Range on HMM: 2-164/174.0
TDYINASFIDGYRQKDYFIATQGPLAhtvedFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTegsvthgeitieikndtlseaisirdflvtlnqpqa
.||||||..|...  ...||.|||||     ||.|..|....|.|||.| .|..  ||..|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

RQEEQVRVVRQFHFHGWPEIGIPAEGKgMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKaEGLLDVFQAVKSLRLQRPHMVQTLEQ
..|  .| . |... .||  | |   . ..... .|.. ... ...|. |||||| |||||..|.  .| . . |.| |... |..||||||.|||| .|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YEFCYK
|.|.|.
yrflyy
0049772 (Phosphotyrosine protein) phosphatases II 148-401 3.9e-52 173.2 In-house 35-286 (314) alignment 
Range on Protein: 148-401
Range on HMM: 35-286/314.0
QGTFELANKEENREKNRYPNILPNDhSRVILSQLDgIPCSDYINASYIDGYkekNKFIAAQGPKQETVNDF----------WRMV--WEQKSATIVM---
 .|.  |....||.||||..||| | .||||. |. .  ||||||||.||.   .||||.|||...||.||          ||||  ..... .|||   
eltilvadlflnrdknryldilpad.nrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTNLKERKeekchqywpdqG------CWTYGnirvcvedcvvlvdytirkfciqPQLPDGCKAPRLVSQLHFTSWPDFGVPf
                  |..| ..            .        ..                        . | |. . .||. ... . .||...| 
evladelsrLdaAlgKtpllildgng...........neptaadlellk.......................eelydpelferlgikylripvpDgsap.

TPIGMLKFLKKVKTLnpVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMhaeqKVDVFEFVSRIRNQRP-----QMVQTDMQYTFIYQALLEYYLYGDTE
..  ...||. ....     ||..|||.||.||||||.|.. .|  .    .|.. | ....|..||      .... .|| ||..|||||. .  ..
lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 154-394 5.7e-52 171.2 In-house 51-282 (290) alignment 
Range on Protein: 154-394
Range on HMM: 51-282/290.0
ANKEENREKNRYPNILPNDHSRVILSqlDGIPcSDYINASYIDGYKekNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG-
 .|. . .|||| ..  || .||||.  || .  ||. | |..| |    || .||. ..|| |.|||| ..| |.|||| .| |    ||.||.|..  
fdkntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

-CWTYGNIRVCVEDCVVLVDYTIRKfCIQPQLPDGCKAPRLvSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLnpvhAGPIVVHCSAGVGRTGTFIVIDAM
   |.|.| |         . .|.|  .  .  |  |  .|   |.  ||||  |. . . .|. |. ....    .||.|||||||.||||||. |.. 
evltfGeitvlcseeddkdaniikk.tlsvrdkdsGkehkl.khlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievg

MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
. ..   ...|. . |  .|| | . || |.||  . ..||..
lqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0036282 (Phosphotyrosine protein) phosphatases II 187-389 1.1e-51 170.3 In-house 2-164 (174) alignment 
Range on Protein: 187-389
Range on HMM: 2-164/174.0
SDYINASYIDGYKEKNKFIAAQGPKQetvndFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDqgcwtygnirvcvedcvvlvdytirkfciqpqlpDG
|||||||..|..   ...|| ||| .     ||.|..|... |.|||...||.. .||..|||.                                  . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

CKAPRLVSQLHFTSWPDFGVPFTPIgMLKFLKKVKTLNPV-HAGPIVVHCSAGVGRTGTFIVIDAMMAMMHaEQKVDVFEFVSRIRNQRPQMVQTDMQYT
    ||. |.... |||.||| ..| .|.|.| |..     . ||..||||||||||||..... |. ... |  ||....| ..|.|||.||||. || 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FIYQ
|.|.
flyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 427-687 1.2e-51 170.4 In-house 23-233 (392) alignment 
Range on Protein: 427-687
Range on HMM: 23-233/392.0
EEEFRKLTNVRIMKEnmRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT
 |||. | .  |...  .... . |.|| |  .|.||| .||.| .      .||.|||.|... ..  .||.||| | ...|||||... .  ||.|.|
feefhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

EVQEREqdkcyqywptegsvthgeitieikndtlseaisirdflvtlnqpqarQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTgNHPI
...| .                                               . ...| | ||||  ||. ..|     .. .|  |. .  |   ||.
klkegd...............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpl

TVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQ
 .||||| ||||  |.. ... . |   ..|||. |  .| .||.|||| ||| | |  | 
iihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_PTPN1_pd Subfamily PTPN1 442-688 2.3e-51 169.2 In-house 23-269 (290) alignment 
Range on Protein: 442-688
Range on HMM: 23-269/290.0
NMRTGNLPANMKKARVIQIIPYDFNRVILSmkRGQEytDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP
..|. .||.| .. |   . |||  |..|   |..   ||||||...  . |  .| |||||..||. ||.|.|| ||...||| .| |.|| ||.||||
ptreaklpenrnlnryrdvspydhsrikle..radn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

TEGSVTHGEIT-IEIKNDTLSEAISiRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNH-PITVHCSAGAGRTGT
.. ..   ..  ...| . .|| .. . . | | . . .. .. |.. .||.  ||. |.|     .....  |..    . .. |  .||||| ||.||
qgeeekellledtklkvkliseerk.syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
|. .  .| ......    .|. . .  || .|  ..|| .| .| |  . .
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 443-687 3.7e-51 168.6 In-house 30-274 (287) alignment 
Range on Protein: 443-687
Range on HMM: 30-274/287.0
MRTGNLPANMKKARVIQIIPYDFNRVILSmKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT
... .  |..|| |  ...|.| .||.|| . |.  .||||| .. .|.... |||.|||.| || ||||...| .| .....|   |  . |||.||| 
fkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

E-GSVTHGEITIE-IKNDTLSEAISIRDFLVTlnqpqARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV----QKQQQQTGNHPITVHCSAGAGR
    .  |  ..  .. | ..   ..| . .        . .. |||.|...  ||. ...    |.| ..  |    . ... ..  |. ||...|.||
revPmrvGGysvvlldydikePeygvralrli.....dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQ
.|...|.  ...| .  | .|| ..|  || .|  .||.  |. . |. . 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0041856 (Phosphotyrosine protein) phosphatases II 451-689 4.3e-51 168.4 In-house 1-170 (182) alignment 
Range on Protein: 451-689
Range on HMM: 1-170/182.0
NMKKARVIQIIPYDFNRvilsmkrgqeYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTevqereqdkCYQYWPtegsvthge
|..| |.  |.|||..|          . |||||....|..  . |||||||| .||.||.||..|.. .|||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

itieikndtlseaisirdflvtlnqpqarqEEQVRVVRQFHFHGWPEIGIPAeGKGMIDLIAAVQKqqqqtGNHPITVHCSAGAGRTGTFIALSNILERv
                              |.  | . |.....||  |.|     ..|.| .|..      ..|. |||||| |||||..|.  .... 
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.

kaeGlLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
   | .....||| .| .||.||.|..|| |.. .. ..
...g.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 134-397 6.8e-50 164.8 In-house 17-279 (307) alignment 
Range on Protein: 134-397
Range on HMM: 17-279/307.0
QFREEFNSLPSGHIQGTFElANKEENREKNRYPNILPNDHSRVILsQLDGIpCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML
....||. |     .|       . | .|||| ..   |..|... ..||. .|||| | |.    . .|||.||||...|. .|| |. ..|  ...||
alvdefrvlakktpegvtv.eafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLKERKEEKCHQYWPDQGCWTygNIRVCVEDCVVLVDYTIRKFCIQPQL-------PDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTlnpv
 .. |  . ||.|||| .   .  .. .   . . . .  ..|.. . .|        | ..  | ...| .. ||| ||| . .. . .|. |.     
ckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....

HAGPIVVHCSAGVGRTGTFIVIDAMM-AMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLY
.  |.||||||||||.|| . |  ..  |.  .   |. ..|  .|.||.  .||..|| .... ||||.| 
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 451-686 1.3e-49 163.6 In-house 3-235 (237) alignment 
Range on Protein: 451-686
Range on HMM: 3-235/237.0
NMKKARVIQIIPYDFNRVILSMKRGQeyTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP-TEGSVTH
|  | |  .|. || .||.|    ..  .|||||....|.      .||.||||  . .|||.|.|. |   ||||| . |... ||..||| |.   ..
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GEITIEIKNDTLSEAISIRDFLVTLNQPQArqeeQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQ-TGNHPITVHCSAGAGRTGTFIALSNIL
| .|. .| .      ..| .|.. .. .     .||.. |..|  ||. |.| .   .. .   . .. .  .   |  .||||| |||| |. .  .|
gvltvslkkkeefsdytvrslllskrltlk....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

ERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
 . | . ..|... |.|.  .||...|| .|| | ....
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 451-686 2.1e-49 162.8 In-house 8-237 (239) alignment 
Range on Protein: 451-686
Range on HMM: 8-237/239.0
NMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSvTHG
|  | |  .|. ||..||.|     . ..||||||..  |      .||||| .. .  |||||.|. .   ||||| . |  . ||.||||   |  . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

EITIEIKNDTLSEAISIRDFLVTlnqpQARQEEQvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGRTGTFIALSNILER
.. . ...  .     || |...    |  | |. | | |.||  ||. |.|     .. |   . |.    | .|  .||||| ||||.|. .  .| .
nlrvtlrktevfadyiirtfvms....qvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrq

VKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
 | .  .|.|. ||..| .||||||| ||| | .  |
akkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 451-686 2.2e-49 162.8 In-house 7-236 (239) alignment 
Range on Protein: 451-686
Range on HMM: 7-236/239.0
NMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSvTHG
|  | |  .|. ||..||.|     . ..||||||..  |      .||||| .. .  |||||.|. .   ||||| . |  . ||.||||   |  . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

EITIEIKNDTLSEAISIRDFLVTlnqpQARQEEQvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqQTGNHPITVHCSAGAGRTGTFIALSNILER
.. . ...  .     || |...    |  | |. | | |.||  ||. |.|     .. |   . |.    | .|  .||||| ||||.|. .  .| .
nlrvtlrktevfadyiirtfvms....qvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrq

VKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
 | .  .|.|. ||..| .||||||| ||| | .  |
akkqktvdifnyvkairedrphmvqtseqyvfihlav
0043147 (Phosphotyrosine protein) phosphatases II 185-389 3.8e-49 162.0 In-house 3-155 (172) alignment 
Range on Protein: 185-389
Range on HMM: 3-155/172.0
PCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLkerkeekchqywpdqgcwtygnirvcvedcvvlvdytirkfciqpqLP
. ||||||||.|.|   ..||| ||| ..|..|||||..|..  .||.||.|                                              | 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

DGCKAPRLVSQLHFTSWPDFGVPfTPIGMLKFLKKVKT-LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMammhaeQKVDVFEFVSRIRNQRPQMVQTDMQ
|. .  ||. |.....|||.||| ..  .|.||. ... |.    ||..||||||||||||..... |.      ......| |. .|..||..||.. |
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YTFIYQ
| |.|.
yrflyy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 423-690 3.1e-47 155.8 In-house 5-259 (267) alignment 
Range on Protein: 423-690
Range on HMM: 5-259/267.0
KIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQeytdYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTI
.  .|.|| .....   . .. .     | .. |. . .||| .||||. |  .    |||||...||..|  ||.||.||  |. ||. .| . |  .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLTEVQEreqDKCYQYWPTE-G-SVTHGEITIEIKNDTLSEAISirdfLVTLNQpQArQEEQVRVVRQFHFHGWpeiGIPAEGKGM-IDLIAAVQKQQQ
|.|| | .   |.  ..|| . | .  . ..|.|   .   .       ..||.  .  ..|  . |  .... |    | .. |     |.. . |.| 
vlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyq....iitlel.kf.knesahnvtlyyykkw...nintnnkpylkplfgilaknql

QTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
. ||.|. |.||.| ||.|||. .   |||.| || .|.|. .. .| ||. .|.|.|.| ...... .. 
engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
0049772 (Phosphotyrosine protein) phosphatases II 417-693 1.9e-46 154.6 In-house 12-283 (314) alignment 
Range on Protein: 417-693
Range on HMM: 12-283/314.0
TTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDfNRVILsMKRGQEYTDYINASFIDGYrqKDyFIATQGPLAHTVEDF------
 ..| |  .|. ..  .. . . .  . ...|..|..| | ..|.|.| |||||  . . . .||||||..||.  .. |||||||| .||.||      
llihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lk.fIatqgpleitvvdfreepvl

----WRMI--WEWKSHTIVM---------------------LTEVQEREqdkcyqywpteG------SVTHGeitieikndtlseaisirdflvtlnQPQ
    |||.  .......|||                     |... ..            .        ..                          . .
yyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk.........................eel

ARQEEQVRVVRQFHFHGWPEiGIPAEGKGMIDLIAAVQKQqqqTGNHPITVHCSAGAGRTGTFIALSNILERVkaeGLlDVFQAVKSLRLQRP-----HM
  .|   | . ... . .|  | .   . . ........      ..|. |||.|| ||||||...  .. .    |. .. .|.. .||.||     ..
ydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgf

VQTLEQYEFCYKVVQDFIDIF
...||||||.......... .
ieqleqyefilealleylkfl
0043147 (Phosphotyrosine protein) phosphatases II 476-684 2.6e-46 152.8 In-house 2-155 (172) alignment 
Range on Protein: 476-684
Range on HMM: 2-155/172.0
QEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVqereqdkcyqywptegsvthgeitieikndtlseaisirdflvtlnq
.|..||||||..|.|.  | |||||||| .|..|||||..|.. ..||.|||                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

pQARQEEQVRVVRQFHFHGWPEIGIPaEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILervkaEGLlDVFQAVKSLRLQRPHMVQT
 .   |  .| . |.....||  | |   . .....  ... ...  ..|. |||||| |||||..|.  .|     .|| ....||. .| .||..||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqn

LEQYEFCYK
 .|| |.|.
psqyrflyy
0046846 (Phosphotyrosine protein) phosphatases II 472-687 5.9e-46 151.7 In-house 5-170 (176) alignment 
Range on Protein: 472-687
Range on HMM: 5-170/176.0
MKRGQEYTDYINASFIDGYrqkdYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHgeitieikndtlseaisirdflv
.   ... |||||..|.|.    ..||||||| .|..||..|..|.. ...|.||| .| .. ||..||| . .. .                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tlnqpqarqeeqvrvvrQFHFHGWPEIGIPAEgKGMIDLIAAVQKQQQQTgnHPITVHCSAGAGRTGTFIALSnileRVKAEGLLDVFQAVKSLRLQRP-
                 |.....||. |.|   . ...|..........   .|. |||||| |||||..|.      .. |  |.|..|.. .| ||| 
.................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

HMVQTLEQYEFCYKVVQ
..||| |||.|.|....
gavqtpeQyrflyefel
0049260 (Phosphotyrosine protein) phosphatases II 194-389 8.7e-46 150.7 In-house 1-144 (152) alignment 
Range on Protein: 194-389
Range on HMM: 1-144/152.0
YIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWpdqgcwtygnirvcvedcvvlvdytirkfciqpqlpdgckaprlv
.||||. ...|||.|||  .|..|||||..|..  ||||||.| |....||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

sQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMammhaeQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
 | ... |||.|||  .. .| .|. .. |.    ||..||||||||||||..... |.      ..|...|.|...|..||..|..  |. |.|.
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 183-394 1.8e-45 150.1 In-house 8-172 (176) alignment 
Range on Protein: 183-394
Range on HMM: 8-172/176.0
GIPCSDYINASYIDGYkeknKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDqgCWTYGNirvcvedcvvlvdytirkfciqpq
  ...|||||..|.|.    ..|| |||  .|. ||..|..|..  ..|.||...| .  ||..|||.  ....|                         
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

lpdgckaprlvsQLHFTSWPDFGVPFTpIGMLKFLKKVKTLNPVHaGPIVVHCSAGVGRTGTFIVIDammaMMHAEQKVDVFEFVSRIRNQRP-QMVQTD
            | ... |||.|||     .|..|. ...    . ||..||||||.|||||.....    ... |. ..|.| ....|.||| ..|||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

MQYTFIYQALLEY
 || |.|...|..
eQyrflyefelll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 133-395 6e-45 148.3 In-house 6-259 (267) alignment 
Range on Protein: 133-395
Range on HMM: 6-259/267.0
KQFREEFNSLPS-GHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDgipcSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIV
.....||. .    ... |      |.|.|.||. . || |..||||.. .     .||||||..||| ||.||. |.| . |. ||. .. .|| ..||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTNLkerKEEKCHQYWPDQG--CWTYGNIrvCVEDCVV--LVDYTIRKFciqpQLPDGCKAPRLVSQLHFTSWpDFGVPFTPigMLKFLKKVKTLNPVH
.||.     ... ...|| .   .  | ..   || ..     || |  .    .|    .. . |.  ..  | .  .   |   || |  . . | . 
lltkv...ftdnirlfwPPkmgqakkyqdl..tvehslekeendyqiitl....elkfknesahnvtlyyykkw.nintnnkp..ylkplfgilaknqle

AG--PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
 |  |.||.||.||||.|||.|||...  .  |. .|.|.|. .||.||. .|.|  .| .|.. | || 
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 133-394 9.8e-45 147.4 In-house 11-268 (281) alignment 
Range on Protein: 133-394
Range on HMM: 11-268/281.0
KQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQ-LDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIV
 .|..||  ||           |.  | .|||| ||   | ||| |   .     .||| | ||     |  .| .||||.||  |||||.|......||
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaiv

MLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPqlpDGckAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTlnpvHAG
|| .. | . ||| .|.| .   |  . .. |  ||  |       .. .     .|    ||...  .  |||. || .   ||| |.|...    .. 
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy...eg..etrlithwlwkewpdwqvpessevmlkilrkira....rst

PIVVHCSAGVGRTGTFIVIDAMMAMMHAEQK-VDVFEFVSRIRN-QRPQMVQTDMQYTFIYQALLEY
| |.||||||||.||.. ..  .  .|.     |. . ||..|   |   |||  || .|.. ||..
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0044763 (Phosphotyrosine protein) phosphatases II 170-399 8.6e-43 141.4 In-house 1-175 (178) alignment 
Range on Protein: 170-399
Range on HMM: 1-175/178.0
PNDHSRVILSQLDGIPCSDYINASYIDGYkeknKFIAAQGPkqetvNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCwtygnirvcvedcvvl
| |..||.|| | |...|||||||.|...     ......|      |......|..  .||.||. .|.  .||..|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vdytirkfciqpqlpdgckaprlvSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMmhaeqKVDVFEFVSR
                         | ... .||.|||  .  .|.|.. .... . . ||..|||||||||.||..... |. .     .....| ...
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

IRNQRPqMVQTDMQYTFIYQALLEYYLYGD
.|..|| .|... |. ..|.  |... ..|
vrerRp.ivpnpgqlrqLyefelrllkesd
0049260 (Phosphotyrosine protein) phosphatases II 486-684 1.3e-42 140.4 In-house 1-144 (152) alignment 
Range on Protein: 486-684
Range on HMM: 1-144/152.0
FIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWptegsvthgeitieikndtlseaisirdflvtlnqpqarqeeqvr
|||||... .|||||||. .|..|||||..|.. .||||||| .|.  .||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vvrQFHFHGWPEIGIPAEGKGMIDLIAAVQKQqQQTGNHPITVHCSAGAGRTGTFIALSNILervkaeGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYK
   |.... ||  | |     ...|. ...|  ..  ..|. |||||| |||||..|.  .|        .....||. .| .||..|.. .|..|.|.
...qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 155-396 2.2e-42 139.9 In-house 44-288 (305) alignment 
Range on Protein: 155-396
Range on HMM: 44-288/305.0
NKEENREKNRYPNILPNDHSRVILsqlDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGC-
 . ....|||| ..   |. || |   .|    .|| | |.    . ..|| .| | ..|  ||| | ...|  .| || ||.|.  .||..|.. .   
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

-WTY--G--NIRVCVEDCVVLV--DYTIRKFCIQPQLP--DGCKApRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLnpvhAGPIVVHCSAGVGRTGT
  ..  .   | | .| .| |   . .  |      .    |.|| | |.. |.  ||| ||| . . .|..|.| ...     ||||||||||.||||.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgeka.rkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgs

FIVIDAMMAMMHAEQKVDVFE-FVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
 .... ..  . | |...  .  . .||.|| . .||| || |..| .|.|..
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 441-686 3.3e-42 139.4 In-house 23-291 (297) alignment 
Range on Protein: 441-686
Range on HMM: 23-291/297.0
ENMRTGNLPANMKKARVIQIIPYDFNRVILsmKRGQEYTDYINASFIDGY--RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQ
|.. . . .. ..| |  .|. .| .|| |  .|.   .||||| ..      .. ..| .||||  ||.|||....|    .|||....||  .|||. 
esfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPT--EGSVTHGEITIEIKNDTLSEaisIRDFLVTLNQPQARqeEQVRVVRQFHFHGWPEIGIPAEG--------------------KGMIDLIAAVQK
|||   ..  . |.. .|   .|  |        .|  |   |  .. ||||   | .||. |.|..                      .......|.  
ywpsvvqerlkagdvvveflsstsde...fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvf

------QQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
      . ..  | .. |||||| ||.|  .    ||.... . . ||   .. || ||. .||||||.|..|..|
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 148-397 1.1e-40 134.1 In-house 43-291 (305) alignment 
Range on Protein: 148-397
Range on HMM: 43-291/305.0
QGTFELAN-KEENREKNRYPNILPNDHSRVILSQLDgipCSDYINASYIDGYK-EKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCH
| .|.  .  . .  |||| ..  .|.| | |..      |||| | |.      ...||.|||| ..|...|| || ..|   |||| .  |    || 
qvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQ---LPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTlnpvHAGPIVVHCSAGVGRT
||||            .| . |       |   ||     |    .    | .|..| ||| |||   .  |..|  ..        |||||||||.|||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrt

GTFIVIDAMMAMMHAEQK-VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLY
|| . |. ..  .  ...   . |.|  .|.||   .|.|.|| ||.. .|.|.| 
gtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
0051082 (Phosphotyrosine protein) phosphatases II 478-685 1.1e-40 134.0 In-house 2-148 (151) alignment 
Range on Protein: 478-685
Range on HMM: 2-148/151.0
YTDYINASFIDGYrqkdyFIATQGPLAhtveDFWRMIWEWKSHTIVMLTEVQEREqdKCYQYWPTEGsvthgeitieikndtlseaisirdflvtlnqpq
..||||.|...|.     .....||||    ||.....|..  |||.|.. .||.  .|..|.| .|                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

arqeeqvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKqqqqTGNHPITVHCSAGAGRTGTFIALSNILERvkaeglLDVFQAVKSLRLQRPHMVQTLE
       . |.......||. |.|   . ..... ....    ..|.|. |||||| |||||..||  .|..      .....|.. .||.||..||. .
.......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYEFCYKV
|. |....
qflfqlfa
0051082 (Phosphotyrosine protein) phosphatases II 186-392 1.5e-40 133.6 In-house 2-150 (151) alignment 
Range on Protein: 186-392
Range on HMM: 2-150/151.0
CSDYINASYIDGYkeknkFIAAQGPkqetVNDFWRMVWEQKSATIVMLTNLKERKeeKCHQYWPDQGcwtygnirvcvedcvvlvdytirkfciqpqlpd
 |||||.||..|.     ... .||     .||.....|..  |||.|....||.  .|..|.|..|                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

gckapRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTlnpVHAGPIVVHCSAGVGRTGTFIVIDAMMAMmhaeqkVDVFEFVSRIRNQRPQMVQTDMQYT
     . | ......|||.|.| ..  .|.||...        ||..||||||.|||||..... |. .      |...| .. .| .|| .||. .|. 
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIYQALL
|...|||
fqlfall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 426-689 1.7e-40 133.9 In-house 18-276 (307) alignment 
Range on Protein: 426-689
Range on HMM: 18-276/307.0
LEEEFRKLTNVriMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKrGqEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVML
| .|||.|..     | . .  . || .| |  ..   | .|... .. |   .||| | ..    .   ||..||||  |. .|| |. . |  ...||
lvdefrvlakk..tpegvtveafsantdknryqdvkcqdkgrivvkfd.g.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TEVQEREQDKCYQYWPTEGS--VTHGE--ITIEIKNDTLsEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqqt
 .| |  . || |||| |     ..||   || ..|    . ..  . |. . . .    .. | .... .. ||. |.|    . |.|. ||. ..   
ckvielakikceqywpleegqklvfgeapntisvanlga.kklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt...

gnHPITVHCSAGAGRTGTFIALSNILERV-KAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
   |. |||||| ||.|| .|.| . ... . .   |. . |. || ||.. .||  || . ..|. ..
..npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 154-396 2e-39 130.3 In-house 30-271 (285) alignment 
Range on Protein: 154-396
Range on HMM: 30-271/285.0
ANKEENREKNRYPNILPNDHSRVILSQLDgipcSDYINASYID-GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG
.  | | . ||| ..   . .||.| . |     ||| ||..    |... .|..|||  ||..|||.|....| | ..||  | |   |||  |.|.. 
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

--CWTYGNIRVCVEDCVV-LVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHaGPIVVHCSAGVGRTGTFIVID
     .|.  . . .|    .  || .     .  | .  |  . ...   |||   |     |... | || .||    ||.|||||||||| ||. ||
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgid

AMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
     .  . ...... |  .|  | | ||. ||. |.|  |.||..
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 449-688 1.1e-38 127.5 In-house 52-281 (290) alignment 
Range on Protein: 449-688
Range on HMM: 52-281/290.0
PAN--MKKARVIQIIPYDFNRVILSmkRGQEyTDYINASFIDGYrqKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWP-TEGS
 .|  .|| |  ...  |  ||||.   |..  ||. | ...|   |  || |||.|. || |.|||. . |  .|||| |. |  . || ||.| .|| 
dkntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

-VTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQeeqvRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQqqqTGnhPITVHCSAGAGRTGTFIALS
 .| ||||.   ...  .|  |.  |   .. . ..     ... ..   ||.  ..     .. .. ...|    .|  |..|||||| ||||||.|. 
vltfGeitvlcseeddkdaniikktlsvrdkdsGke....hklkhlkikswpdksvalstlallrtlrilrka...sG..pvvvhcsaGiGrtGtfvaie

NILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
  |. .     ||. . |..||  |   ||   ||    ... |
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0044763 (Phosphotyrosine protein) phosphatases II 462-686 1.6e-38 127.4 In-house 1-167 (178) alignment 
Range on Protein: 462-686
Range on HMM: 1-167/178.0
PYDFNRVILSMKRGQEYTDYINASFIDGYrqkdYFIATQGPlahtvEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSvthgeitieikndtls
|.|..||.||. .| |..||||||.|...    .......|     .|......|.. ..||.||| .|. . ||..|||.| .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

eaisirdflvtlnqpqarqeeqvrvvRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQqTGNHPITVHCSAGAGRTGTFIALSNILERvkaeGLlDVFQA
                           |... ..|  | |   . . ........ .. . ..|. |||||| ||.||..|.  ....    || ....|
..........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleea

VKSLRLQRPhMVQTLEQYEFCYKVV
.. .| .|| .|.. .|....|.. 
ielvrerRp.ivpnpgqlrqLyefe
PTPc_DSPc_SM00012 293-393 8.6e-38 124.1 In-house 2-105 (105) alignment 
Range on Protein: 293-393
Range on HMM: 2-105/105.0
VSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA--GPIVVHCSAGVGRTGTFIVIDAMMAMMHAE-QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
|...|.|.|||.||| ..  .|..|..||. .  ..  .|.||||||||||||||...| .. ....| ..||.|..|...|.|||.||||..|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 157-401 1e-37 124.4 In-house 50-295 (310) alignment 
Range on Protein: 157-401
Range on HMM: 50-295/310.0
EENREKNRYPNILPNDHSRVILsQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGC-WT
...  |||| ...  | ||| | ..|     ||| | |.     .. || .||| | |. |||||...... .|..| .  |    ||  |||  |   |
kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGNIRVC--------VEDCVVLVDYTIRKFCIQPQlPDGCKAPRlVSQLHFTSWPDFGVPFTPIGMLkflkKVKTLNPVHAGPIVVHCSAGVGRTGTFIV
|| |||          | | . | .   .  .. | |   |  | || ...  ||| |||      .      . |  |  || |||||||..|... . 
ygcirvtnlsesseefeicnlavtfvpdnvpvdeq.panlkelr.vslikwpnwpdrgvpdekchtv....pqrllaqvrhgpcvvhcsagkdrlyvvva

IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYyLYGDTE
..  .  ..  .|||. | .. ....| . .||..||..| .  . .   |.||
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif.argete
subfamily_ptpA1_pd Subfamily ptpA1 135-355 1.4e-37 124.4 In-house 23-256 (418) alignment 
Range on Protein: 135-355
Range on HMM: 23-256/418.0
FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKnKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT
 .|||  |            .|. |  |||| |||| .|.|| | ...    |||||| ||||   | .||..|||  .|. ||||||||..   ||||.
ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmls

NLKERKEEKCHQYWPDQGC----WTYGNIRV-CVEDCVVLVD---YTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT----
   |    || .|||.|        |||         | ||.      |.   .          | ..| ..  |||. .|     . ..|. .      
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

LNPV--HAGPIVVHCSAGVGRTGTFIVIDAMMAMM
. |   .  ||.|||||||||||||     ||  .
iipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 159-396 2.6e-37 123.4 In-house 43-272 (288) alignment 
Range on Protein: 159-396
Range on HMM: 43-272/288.0
NREKNRYPNILPNDHSRVILSqldgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGN
|  ..|| |.   | .|| ||      .  ||.|  .   | |...| || | . |.. .|.|. |.    ||||..| |.  ||  .|.| .   .   
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

IRVCVE--DCVVLVDYTIRKFCIQPQLPdgCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTlnpvHAGPIVVHCSAGVGRTGTFIVIDAMMAMMH
 |.|    .  . .| ...   .. . .   . . .| .||.  |.| |||   .  |..|. .|.    .  |||||.|||||||||.|.|  .. .. 
grlctvvkkkradidklvkvsllriske..geekvivkilhlleWdddgvPenylsplrllevlks....lqkPivvhssaGvGrtgtlililialeslr

AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
 .  . . ..... |..| . .|| ||| .... .||. |
lddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 446-690 3.3e-36 119.4 In-house 32-269 (281) alignment 
Range on Protein: 446-690
Range on HMM: 32-269/281.0
GNLPANMKKARVIQIIPYDFNRVILSMK-RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG
 | | | || | ..|   |  || | .|   .. |||| | .|     |  .| ||||   |  |||||||. .. .|||| .. | ...|| .|.| . 
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

svtHGEITIEiKNDTLSEAISIRDFLVTLNQpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQqqqtgNHPITVHCSAGAGRTGTFIALS
   |  . .. |     |  ..   |||    .   | . |.. .. .. ||.  .|   . |. ..  .. .       |  .||||| ||.||..|. 
...hcclqfd.klsvsyedstvnkslvttrl.nlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsgtlmave

NILERVKAE-GLLDVFQAVKSLRLQ-RPHMVQTLEQYEFCYKVVQDFI
  |. ...   | |. | |  ||.  |   ||||.|| . .||. || 
ialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_ptpA1_pd Subfamily ptpA1 426-644 4.7e-36 119.4 In-house 23-250 (418) alignment 
Range on Protein: 426-644
Range on HMM: 23-250/418.0
LEEEFRKLTNVrIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDyFIATQGPLAHTVEDFWRMIWEWKSHTIVML
..|||| | .  .   .   |.   |  | |  .|.| .. || |   . .| .||||| .|||   |. ||.|||||  |. |||||.|| . . ||||
ikeefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivml

TEVQEREQDKCYQYWPTEGSV------THGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQ
.   |  . || .||| .           |.  .   .  | | |   .  .   . .   | . | . |... |||.  ||   . . .|. .. ..|.
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QT-----GNHPITVHCSAGAGRTGTFIALS
|       | || |||||| |||||| .  
qiipssdrnvpiivhcsagvgrtgtfctav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 426-689 7e-36 118.4 In-house 26-288 (305) alignment 
Range on Protein: 426-689
Range on HMM: 26-288/305.0
LEEEFRKLTNVR--IMKENMRTGNLPANMK--KARVIQIIPYDFNRVILSMKRgqeYTDYINASFIDGYR-QKDYFIATQGPLAHTVEDFWRMIWEWKSH
| ||||.|..     | ...   |  |...  | |  ..   | . | |.       .||| | ..      .  ||..|||| .|...|| |. . |  
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

TIVMLTEVQEREQDKCYQYWPTE-GSVTHGEITIEIKNDTLSEAISiRDFLVTLNQPQARQ-EEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQ
 ||||    |  . || ||||.  |   .    | ..| . |  .  ||  . .   .     .|   ||....  ||. |.|      ..|..|..  .
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpme.rdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk

qqtgnHPITVHCSAGAGRTGTFIALSNILERVKAEG-LLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
      || |||||| ||||| .|.  |||..  .     . . ||.|| || . .|.  || | ..|. ..
.....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
PTPc_DSPc_SM00012 587-687 1.1e-35 117.4 In-house 2-104 (105) alignment 
Range on Protein: 587-687
Range on HMM: 2-104/105.0
VRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYK
|...|..|||. |.| |.. ...|..||.|.... . ..|. ||||||.||||||.||. .|.....| . .|.|| ||.|| |||.||||.||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VVQ
...
all
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 451-679 1.6e-34 114.0 In-house 50-270 (301) alignment 
Range on Protein: 451-679
Range on HMM: 50-270/301.0
NMKKARVIQIiPYDFNRVILSMKRGQEYTdyINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGS--VTH
. .| |  .. | . .  .  .. |.     | | .|.   . . ||||||||  | |||| |.  .. ..||||..  |....|| .| |.. |  .  
pkdkhryptv.PckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

G--EITIEIKNDTLSEAISIRDFLVTlnqpQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqqtgnHPITVHCSAGAGRTGTFIALSNI
|  .|.|. |.  |.. || | . |.     . .. . | |  . .. |.. |.|     . ||.  |.| .     .|| |||||| ||. .||.   .
grfkikiknkelilnkkiskrtleve....dstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse.....kPivvhcsaGiGrsvafigteyl

LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQY
  .|.|.  ... .|.| || .| . ||| .| 
areveadptieltealkhlrehrwngvqtnsql
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 130-316 6.9e-34 112.1 In-house 4-189 (297) alignment 
Range on Protein: 130-316
Range on HMM: 4-189/297.0
DDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILsqLDGIPCSDYINASYIDGYKEKN--KFIAAQGPKQETVNDFWRMVWEQKS
.| |.  .| ..|      ..|  |...    |||| .||  | .|| |  | .|. .||||| |.   .|..  |.| |||| ..||.|||..|.||  
edrkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdv

ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGcKAPRLVSQLHFTSWPDFGVPFTPIGMLKF
 .|||...|.|   .||  |||.          | ||      |   | .  . ||    .  | |    | |||| |||     . .|
rvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 159-411 7.6e-34 111.8 In-house 50-296 (301) alignment 
Range on Protein: 159-411
Range on HMM: 50-296/301.0
NREKNRYPNIlPNDHSRVILSQLDGIPCSdyINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGC--WTY
...|.|||.. | . |  .    ||      | | .|.   . ..|||.||| ..| .||| |.   .  .||||..  |..||||..| | .       
pkdkhryptv.PckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNpvhaGPIVVHCSAGVGRTGTFIVIDAMMAMMH
|  .. ...  ....  | |  .. .   |  |.| |    ...|.| ||| . . . .... ||  .     |||||||||.||. .||  . .   ..
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareve

AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLeYYLYGDTELDVSSLEKHL
|...... | . ..|..| . |||  |  ..    . | |  . ..|.   |..|
adptieltealkhlrehrwngvqtnsqlywmtlGtv.yrlikeygfdmkiyeeql
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 424-688 6.8e-33 108.5 In-house 24-288 (310) alignment 
Range on Protein: 424-688
Range on HMM: 24-288/310.0
I---GLEEEFRKLTNVRimKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGqEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH
.   ||  ..|||   .     .       .|.| |  ...  |  || | . .   | ||| | ..     .. || .|||| ||. ||||||.. .. 
lgieglvkqyrkldakq..dssltyeaykkymhknrysdvvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

TIVMLTEVQEREQDKCYQYWPTEGsVTHGEITIEIKN-DTLSEAISIRDFLVTL---NQPQARQEEQVRVV--RQFHFHGWPEIGIPAEGKGmidliAAV
.|..|  | |  . ||  |||. | ||     | . |    || . | .. ||.   | |   |  ... .     ..  ||. |.| |        .  
silllckvgeegrpkcvgywpslg.vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.....tvp

QKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
|.   |    |  |||||| .|... .||   .....    .|. . .  |. .|   .||  || .  .|   
qrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 421-690 1e-32 108.1 In-house 19-287 (305) alignment 
Range on Protein: 421-690
Range on HMM: 19-287/305.0
FDKIGLEEEFRKLTNVRIMkENMRTGNLPANMKKARVIQIIPYDFNRVILsmkRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSH
   .|| .||  .  .  . | |..     . .| |  ..   | ||| |   .|    .|| | ..    .   || || || .|  ||| | .. | .
kgpaglraefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkve

TIVMLTEVQEREQDKCYQYWPTEGS----VTHGEITIEIKNDTlSEAISIR-DFLVTLNQPQA---RQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIA
.| || ...|.   ||..|....         ..  | .| .. |.....| |   .... .       |..| | ..|.  ||. |.||    ...|..
aifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfes.svtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle

AVQkqqqqTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDV-FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
  .     .   ||.|||||| ||||. . |  ||... |   ..   . .. .| ||   .|| .|| | ..|. ...
kar.....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_egg_pd Subfamily egg 150-405 7.7e-32 105.2 In-house 31-283 (307) alignment 
Range on Protein: 150-405
Range on HMM: 31-283/307.0
TFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERkeEKCHQYWP
... | ...|.|| | . .  .| ||| |    |    |.| | ...|    |.|| || | ..||.||||||....   |||||  ||   |.|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DQGC----WTYGNIRVCVEDCVVLVD--YTIRKFCIqpQLPDgcKAPRLVSQlHFTSWPDFGVPFTPIGMLKFLKKVKTlnpvhagPIVVHCSAGVGRTG
           |..|.   .     |  ... |. .    .|  .  | .       .   .  ..|. .|. |... .       |.||..  || ...
kaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd..deerfleh.wqgdvnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaa

TFIVID-AMMAMMHA-EQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY---LYGDTELDVS
|.. |. |.. ..     |  | . |  .| .|.  |.. ..| |.|. .| ..   .    |||| 
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 450-689 4.4e-31 103.0 In-house 42-270 (288) alignment 
Range on Protein: 450-689
Range on HMM: 42-270/288.0
ANMKKARVIQIIPYDFNRVILSmkrgQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE-GSVTH
||  . |  ..   |. || ||     .   ||.|  .   . |  .| .| ||  |.| .|.|. |   . ||||.|. |. ..|  .|.|.. |  ..
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

-GEItieiKNDTLSEAISIRDFL-VTLNQPQARQEEQVrVVRQFHFHGWPEIGIPAEGKGMIDLIAAVqkqqqQTGNHPITVHCSAGAGRTGTFIALSNI
 | .     ...  .   |   . |.| . .   ||.| .|.. |.. |.. |.| . .  . |.  .     .. ..|| ||.|||.|||||.|    .
igrl....ctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililia

LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
|| .. .  | . . ...|| .| . .||  || . ...| . 
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 158-398 1e-30 101.5 In-house 42-278 (312) alignment 
Range on Protein: 158-398
Range on HMM: 42-278/312.0
ENREKNRYPNILPNDHSRVILSQLDGIpcsdYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ-GCWTY
  .. ||||||   |  |  |.  . .    || | ..      ..|...||| ..|.  ||...    |..|..|. . |   ||| .|  |  |    
kfkdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl

GNIRVCVEDCVVLVDYTIRKFCIQ-PQLPDGCKAPRLVSQL---HFTSWPDFGVPFTPIGMLKFLKKVKTlnpvHAGPIVVHCSAGVGRTGTFIVIDAMM
 . ||  | |  .      |  |    |    ||    |.|    ..|||| |.| .    |..|  ||        |.. |||||||||||...|..|.
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmi

AMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYyLYG
| .   .| .| .    .|..| . |..  || .  ...||. || 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef.lys
subfamily_CG42327_pd Subfamily CG42327 427-616 2e-29 97.3 In-house 8-192 (319) alignment 
Range on Protein: 427-616
Range on HMM: 8-192/319.0
EEEFRKLTNVRIMKEnmrtgNLPAN-MKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ-KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVM
 ||||.| ..    .     ..|.   .|.|||...|    ||.|  .  .. . |..||.. ||.. . ..||.| .|  .  ||||..|| .| .|| 
aeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LTEVQEREQDKCYQYWPTEGS----VTHGEITIEIKNDTLSEAISIRDFLVtlnqpQARQEEQVRVVRQFHFhGWPEIGIPAEGKGMIDLIAAVQK
||...|   ..| .|.||. .     ..|.| . .|.    .   |  .|.     .  ..|. | .  . .  |.| ..||| . .| ..  |..
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.....krvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 157-395 2.2e-29 96.9 In-house 49-285 (302) alignment 
Range on Protein: 157-395
Range on HMM: 49-285/302.0
EENREKNRYPNILPNDHSRVILSQLDgipcSDYINASYIDGYKEKNKFIAAQGPKQETV---NDFWRMVWEQKSATIVMLTNLKERKEeKCHQYWP-DQG
 .| .||. ...   |. .|.|..       .|.||| ..  . ... | || ||....   ..|||||...| ...|.|   .| |.   ....|  .|
kknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

CW-TYGNIRVCVEDcVVLVDYTIRKFCIQpQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM
 . .||...| .   |  .. .  ...|   ||.||    |..  ..| |..  ||     . |  .|| ...     ..|.    |.|| |.|..  . 
dykeygkmfvNnrk.VekaeeektryviE.vlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
.  ....... . | |  ||.|||..|..  ||...| ||| | 
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_CG42327_pd Subfamily CG42327 136-321 6.4e-29 95.6 In-house 8-191 (319) alignment 
Range on Protein: 136-321
Range on HMM: 8-191/319.0
REEFNSLPsGHIQGTFelANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKE-KNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT
 |||. ||   |  .   .     ..|.|. |..|  ..||.| .    . . |..|||. ||.. .| .|||| . ...  ||||.||||.| .|| ||
aeefrdlP.qliarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

NLKERKEEKCHQYWPDQ----GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDGcKAPRLVSQLHFtSWPDFGVPFTPIGMLKFLKKVK
.| |   ..| .|.| .    .  .||.|.| . .  |   | |  . ..    |. .  | ..   .  |.. .||  .  ..  | .|.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrv..dk.eesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 199-389 1.3e-28 94.6 In-house 2-198 (199) alignment 
Range on Protein: 199-389
Range on HMM: 2-198/199.0
KEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLpDGCKAPRLVSQL
| . ..||.| | .||. |||.||||  |  |||. . .  ||     |||    |.  ||.. |...  ..  ||||  . .  .      . | .|. 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishy

HFTSWPDFGVPFTP--IGMLKFLKKV-KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMaMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
 |||| .   |     .|..   ..| |  .  .  |..|||| | | || |. .|  .   | | |   ||.||   |.|. |  .. .  .| ||||
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 200-389 1.9e-28 94.0 In-house 2-197 (198) alignment 
Range on Protein: 200-389
Range on HMM: 2-197/198.0
EKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLpDGCKAPRLVSQLH
 . ..||.| | .||. |||.||||  |  |||. . .  ||     |||    |.  ||.. |...  ..  ||||  . .  .      . | .|.  
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.tappstreishyq

FTSWPDFGVPFTP--IGMLKFLKKV-KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMaMMHAEQK---VDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
|||| .   |     .|..   ..| |  .  .  |..|||| | | || |. .|  .   | | |   ||.||   |.|. |  .. .  .| ||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 450-689 2e-28 94.1 In-house 34-269 (285) alignment 
Range on Protein: 450-689
Range on HMM: 34-269/285.0
ANMKKARVIQIIPYDFNRVILSmkrgQEYTDYINASFIDG-YRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE-GS-V
||    |  ..   .  ||.|     .   ||| ||..    ...  .|.|||||  |. |||.||.. |   ..||  . |   .||  |.| . |  |
anpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

THGE--ITI-EIKNDTLSEaiSIRDFLVTLNQPQARQEEQVrvVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQtgNHPITVHCSAGAGRTGTFIAL
  |.  ||. | |.....   .| . |  .|  .|  |     . . .   ||.   | . . ||.|   |.| . .  ..|| |||||| ||| ||. .
kfgkyeitlteckeeaiag..tilnaltvintedasseply..mnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgi

SNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
     |.  .  ..... |. .|  | . ||.  |. | | |. ..
dyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 291-431 3.8e-28 93.0 In-house 89-230 (440) alignment 
Range on Protein: 291-431
Range on HMM: 89-230/440.0
RLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT-LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
| . | |. .||| |||     .||... |.   . .  ||..||||||.||||  |..|...   .  ...|.| |.. .||.|||||||  ||.|...
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

ALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR
|.||  | ||| .    . .... ..    | ||  |..|| 
avlegllcgdtliledditerveqiqwpnphtdksplqqefe
0048076 (Phosphotyrosine protein) phosphatases II 247-394 4.4e-28 93.2 In-house 2-142 (145) alignment 
Range on Protein: 247-394
Range on HMM: 2-142/145.0
YWPDQ--GCWTYGNIRvCVEDCVVLVDYTIRKFCIQPQLPDGCKapRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHaGPIVVHCSAGVGRTGT
|||..  . . .|..  ...|   | |. |.        .....  ||. |.....|||.|||  .  .|.||. .... . . ||..||||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

FIVIDAMMAmmhaeQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
..... |.      ..|...| . ..|.|||..|... |. |.|...||.
lvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_egg_pd Subfamily egg 440-691 4.5e-28 92.8 In-house 29-272 (307) alignment 
Range on Protein: 440-691
Range on HMM: 29-272/307.0
KENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEReqDKCYQY
.....|     |..|||  ..   |. || | ..|||   |.| |  ..|    . || .| ||  ||.|||||... . . |||||  .|   ..|  |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPTEGSVTHGE--ITIEIKNDTLSEAisiRDFLVTLNQPQARQEEqvrvVRQFHFHGWPeIGIPAEGkGMIDLIAAVQKQQQqTgNHPITVHCSAGAGRT
||   | .      ...|.|  . ..    | | .. . .    .      . .   |    .   .  .   .  ..| ..    .|. |..  |  ..
wpkaesdslvtvpGslrienlkvdsk...adplfrvtklklvGgd....deerflehwq.gdvnnss.dvysplrvlrklrn.l.skpvvvqdilGvska

GTFIALSNILER-VKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF-ID
.|..|.   |   ..       | .||. |||.|.  |..  .| | |..|  |  |
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 153-395 5.2e-28 92.4 In-house 42-344 (349) alignment 
Range on Protein: 153-395
Range on HMM: 42-344/349.0
LANKEENREKNRYPNILPNDHSRVILSQ--------------LDGIPCSDYINASYID--GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNL
|..  |   |||| .||| .||||.| .               |.    ||||| |.    .. ..|.|| | |   ||.||....  ..   .. |.. 
lseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

KERKEEKCHQYWPD----------QGCWTY-GNIRVCVEDCVVLVD-----YTIRKFCIQPQLPDG------CKAPRLVSQLHFTSWPDFGVPFTPIGML
||   |||..|| .          |  . |  |.. ..       |       ..| |..|.  |        . |  . || .  |.| .. . || .|
kelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisil

KFLKkVK-----------TLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQ----KVDV--------FEFVSRIRNQRPQMVQTDMQYTFIYQAL
. |. ||            |.  .  ...|||||| ||||... .| ......  |    |...        .  |  .| || .|||   |. .||.||
qale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal

LEYY
|.|.
Lkyf
0048179 (Phosphotyrosine protein) phosphatases II 266-389 1.6e-26 88.2 In-house 22-139 (144) alignment 
Range on Protein: 266-389
Range on HMM: 22-139/144.0
CVVLVDYTIRK---FCIQpqlPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPvHAGPIVVHCSAGVGRTGTFIVIDAMMammhaEQKVD
   | .. |.    .. .    .     | . |.....|||.|||  .  .|.||. .... . . ||..||||||||||||..... |.     .....
lellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klgls

VFEFVSRIRNQRPQMVQTDMQYTFIYQ
..| . ..|..||..|... |. |...
leealalvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 493-685 8.6e-26 85.3 In-house 4-199 (199) alignment 
Range on Protein: 493-685
Range on HMM: 4-199/199.0
KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVT--HGEITIEIKNDTLSEAISIRDFLVTLNQpQArqEEQVRVVRQF
.  .|||| || .|. |||.|.||  |  |||. . |   .     ||||  | |  .| ...  |  |     .|  ...| |   |      | . ..
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.ta..ppstreishy

HFHGWPEIGIPAEG--KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSnILERVKAE---GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKV
 |  | |   |      |..     | |. .|  . |. |||| | | || |.||  |  | . |    ..|.|.  | ||  |  .. .|..|.| |.|
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald.igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 495-685 9.6e-26 85.2 In-house 5-198 (198) alignment 
Range on Protein: 495-685
Range on HMM: 5-198/198.0
YFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVT--HGEITIEIKNDTLSEAISIRDFLVTLNQpQArqEEQVRVVRQFHF
 .|||| || .|. |||.|.||  |  |||. . |   .     ||||  | |  .| ...  |  |     .|  ...| |   |      | . .. |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt.ta..ppstreishyqf

HGWPEIGIPAEG--KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSnILERVKAE---GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKV
  | |   |      |..     | |. .|  . |. |||| | | || |.||  |  | . |    ..|.|.  | ||  |  .. .|..|.| |.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald.igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 584-688 2.6e-25 83.7 In-house 88-192 (440) alignment 
Range on Protein: 584-688
Range on HMM: 88-192/440.0
VRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY
 |...|.|..|||. |.|     .. .|  |.. |...|| |. |||||||||||  ||. .||  .|    .|.|  ..|.| .||.|||| ||| | .
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

KVVQD
..| .
eavle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 160-396 1e-24 82.2 In-house 20-257 (290) alignment 
Range on Protein: 160-396
Range on HMM: 20-257/290.0
REKNRYPNILPNdHSRVILSQLDGIPCSDYINASYIDgYKEKNKFIAAQGPKQET-------VNDFWRMVWEQKSATIVMLTNLKERKEE----KCHQYW
  ..|... | . ..||.| .      .||| |...  . .  ..|. | |....       ...|| |. . |.  .||| . .|....     | .| 
emdqRlevpLve.atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDQG--CWTYGNIRVCVEDCVVLVDYTIRKFCIQPQlpDgcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKtlnpVHAGPIVVHCSAGVGRTGTFI
|..     ..... |   . .   |  .|. ... .  |  . .  |    . .| .  |. ... .|. ..|||     .  |..|||  |. |  .. 
pesvgeelkfkgltvkCkskekeddvetRelvvkfd..d..eeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAala

VIDAMMAMMH-AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLeyyL
 |.  . ..   ...| . . .. .|.|| ..........|.  ...   |
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...l
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 418-690 1.5e-24 81.0 In-house 20-285 (302) alignment 
Range on Protein: 418-690
Range on HMM: 20-285/302.0
TTHFDKIGLEEEFRKLTNVRIMKENmrTGNLPANMKKARVIQIIPYDFNRVILSMKRgqeyTDYINASFIDGYRQKDYFIATQGPLAHTV---EDFWRMI
....|.. ...|| |. ....  |.       .|.|| .  ..  .| |.|.|...      .|.||| ..    .   | .| |   ..   |.||||.
vksldtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmv

WEWKSHTIVMLTEVQEREQdKCYQYWP--TEGSVTHGEITIEIKNDTLSEAISiRDFLVTLnQPQARQEEQVRVVRqfHFHGWPEIGIPAEGKGMIDLIA
.. |  ..|.|   .| ..    ...|  ..  ...|.. . ..    .|.     . . .  |.   .  .  |   ... |..  .| .   .|  .|
fqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEv.lPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaa

AVqKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 |  .... ..... .    |||| |.|..|   .|.....    . . |||.| |||..|..|.|| . | ..  .|
kv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
0048076 (Phosphotyrosine protein) phosphatases II 577-688 4e-24 80.3 In-house 37-141 (145) alignment 
Range on Protein: 577-688
Range on HMM: 37-141/145.0
QARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQtgNHPITVHCSAGAGRTGTFIALSNILErvkaEGlLDVFQAVKSLRLQRPHMVQTL
   .|  .| . |... .||  |.|   . .......... ...  ..|. |||||| |||||..|.  .|.    .| .....|.. .| |||..|.. 
tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnp

EQYEFCYKVVQD
.|..|.|.... 
gqlrflyefele
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 154-252 5.1e-24 79.6 In-house 42-154 (350) alignment 
Range on Protein: 154-252
Range on HMM: 42-154/350.0
ANKEENREKNRYPNILPNDHSRVILS--------QLDGIPCSDYINASYIDGY----KEKN--KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKER
..  |   |||| |||| .||||.|         .   .  .|||||.|.       . .   |.||.|.| ..||.||.... . |   |..||.. | 
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

KEEKCHQYWPDQG
  |||..||.. .
nlekcyrYWqegs
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 195-387 1.8e-23 77.4 In-house 83-280 (302) alignment 
Range on Protein: 195-387
Range on HMM: 83-280/302.0
IDGYKEKNKFI-AAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCV-VLVDYTIRKF------CIQPQLP
.|| ..|.|       ||..|.. .| .. . . | .| |....| .|.|| .|. |.  |  ..|.  |   .    | ..| .|        |. .  
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

DGcKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNpvhaGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQY
   | .. |. |.|..||| | |  .   |. ||  ..        ..||||||||||||.. |   . .   ..  |. . |  .|. |   ||.. | 
kk.kvkktvdilafsawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

TFI
...
iyl
0048179 (Phosphotyrosine protein) phosphatases II 579-684 5.7e-23 76.7 In-house 41-139 (144) alignment 
Range on Protein: 579-684
Range on HMM: 41-139/144.0
RQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQqtGNHPITVHCSAGAGRTGTFIALSNILervkAEGlLDVFQAVKSLRLQRPHMVQTLEQ
 .|.  | . |... .||  |.|   . .......... ..   ..|. |||||| |||||..|.  ..     .| |....|.. .| .||..|.. .|
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YEFCYK
..|...
lrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 453-573 1.4e-22 74.9 In-house 49-184 (350) alignment 
Range on Protein: 453-573
Range on HMM: 49-184/350.0
KKARVIQIIPYDFNRVILS--------MKRGQEYTDYINASFIDGY-----RQKDY-FIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQ
 | |  .|.||. .||.|         .|   .  |||||...         . |. .||||.||  ||.||...| . | . |..||. .| . .|||.
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPtEGSVTHGEITI--EIKNDTLSEAISIRDFLVTL
||. |||.    . .    .| .  . .|.. . |  
YWq.egsydditvklaskwenimgindsslysadvkk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 201-406 4.7e-22 73.3 In-house 34-231 (255) alignment 
Range on Protein: 201-406
Range on HMM: 34-231/255.0
KNKFIAaqgpkqeTVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDcvVLVDYTIRKFCIQPQLPDgCKAPRLVSQLHF
|| ..        ||. |....  .|. ..|||....| . |||..|.|   ..   . .. |.. .     |  .|   |  .| .  |  . |   ..
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlge.kkkthtvkhysy

TSWPDFGVPFTPIGMLKFLKKVKTlnpvhAGPIVVHCSAGVGRTGTFIVIDAMMA-MMHA---E--QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALL
. |..   |  .  .|. || |.      . ..|||||.|.||. .|.... .   |...       ..|  ...  .|..|.. ..| .| .|    .|
kGWieknaPelareilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EYYlYGDTELDVSS
... .  .||.   
dlv.fpkgeleaky
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 465-686 3e-21 70.8 In-house 32-255 (290) alignment 
Range on Protein: 465-686
Range on HMM: 32-255/290.0
FNRVILSMKRGQEYTDYINASFIDgYRQKDYFIATQGPLAHT-------VEDFWRMIWEWKSHTIVMLTEVQEREQD----KCYQYWPTE--GSVTHGEI
 .||.|     .   ||| |...  . .   .|.|| |....       .|.|| |. . |.. .||| |..|....     | .| |..  .... . .
atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

TIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRvVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQqqTgnhPITVHCSAGAGRTGTFIALSNILERVK
|.. |.    . . .|  .|. ..     ||.   |    ..|| .. .. . | ...||  |....  |   |. |||  |  |  .. |.      . 
tvkCkskekeddvetRelvvkfdd.....eeeft.vtHsllkgWnklnvqedtktllsliqkvkask..t...pvivHcvdGiSrsAalaaiilgyQkia

-AEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV
  .| . . ...|.|| || ..... ... |   ..
etsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 475-691 2.1e-20 67.7 In-house 64-277 (312) alignment 
Range on Protein: 475-691
Range on HMM: 64-277/312.0
GQEyTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT-------EGSVTHGEITIEIKNDTLSE-AISI
|.|   || | |.    . . |..|||||  |.  ||..     | .|..|. . |   .|| .|          |    . |   ||.    |   |. 
gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkith

RDFLVTLNqpQARQEEQvrvVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQqtgnhPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLR
| . | ..   . || .   . .. .  ||. |.|        |..||.|...     |.  ||||| |||||.. .  ..  ..     .| ..   ||
rvlkvvvk..atgqesk...lnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllr

LQRPHMVQTLEQYEFCYKVVQDFID
 .|   |... || .. ..| .|. 
kdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 499-680 1.5e-19 64.5 In-house 96-278 (302) alignment 
Range on Protein: 499-680
Range on HMM: 96-278/302.0
TQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTE--GSVTHGEITIEIK--NDTLSEAISIRDFLV-TLNQPQAR-QEEQVRVVRQFHF
   |   |.| .| .| ...   .| |... | |. || .|. ..  | .. |. |.. .  .. |.|    ..| . |..    . .... . |  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

HGWPEIGIPAEGKGMIDLIAAVQKQQQQtgnhpITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYE
 .||. | |.| .  .|..   .  ...     . |||||| |||||..|.   ..  . .   |. . |. .|  |   ||. .|  
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 447-690 1.8e-19 64.5 In-house 43-279 (303) alignment 
Range on Protein: 447-690
Range on HMM: 43-279/303.0
NLPANMKKARVIQIIPYDFNRVILSmkrgqeYTDYINASFIDGYRQKDyFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV
..  ||.| | ...|  |  .| ||       . || ||...   .|   | || ||.||  |||.|| | | . ...|    | ..      .| .   
qfvknmdknrfvdvicldhskvkls......dssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

T-HGEITIEIKNDTLseaISIRDFLVtLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK-GMIDLIAAVQKQQQ-QTGNHPITVHCSAGAGRTGTFIAL
    | .| . .      . . |  | |.     . .    .   |.. ||   ||..|   ..  |  .|   .  . ..|      .| ||.|||  .
lkfeersirvgefkr...velgdgwv.lkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

SNILERVKA-EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
      ... .  ||. . .. .|  | | || | |. . | .. . .
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 155-396 1.9e-19 64.4 In-house 43-280 (303) alignment 
Range on Protein: 155-396
Range on HMM: 43-280/303.0
NKEENREKNRYPNILPNDHSRVILSQldgipcSDYINASYIDGYKEKnKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD-QGC
.  .| .|||. ...  |||.| ||.      | || |||..   .| | | .| | . |  |||.|. |||   ...|    | ..   .  .|  |  
qfvknmdknrfvdvicldhskvklsd......ssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf

WTYG--NIRVCVEDCVVLVDYTIRKFCiqpQLPDGCkAPRLVSQLHFTSWPDFGVPFTpiGMLKFLKKVKTLNPV-----HAGPIVVHCSAGVGRTGTFI
  .    |||     | |.|    |      . .|     ..   |. .||   .|    |  ||.|..  |. |     .. | |    .|.||.||| 
lkfeersirvgefkrvelgdgwvlkvl...svsngd.yksflhvhhykawphnsipsd..gspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfa

VIDAMMAMMHAEQK-VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYL
....    .|.||  .|.   .  .|| | . ||   |....|  | |. |
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 290-395 2.3e-19 64.3 In-house 214-344 (350) alignment 
Range on Protein: 290-395
Range on HMM: 214-344/350.0
PRLVSQLHFTSWPDFGVPFTPIGMLKFLK-K---V------KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA---MMH----AEQKVD--------VF
|  | ||..  |.| .. . |. .|. |. |   .      . |.  .. ||.||||||||||||.. .| ..    ...      .|.|        ..
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

EFVSRIRNQRPQMVQTDMQYTFIYQALLEYY
  | ..|.|| .|||.  |. |||.||| |.
iivnelrkqrismvqnldqfifiYeallfyf
subfamily_hpo-7_pd Subfamily hpo-7 212-400 7.1e-19 62.7 In-house 44-232 (263) alignment 
Range on Protein: 212-400
Range on HMM: 44-232/263.0
QETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD--QGCWTYGNIRVCVEDCVVlvDYTIRKFCIQPQLPDgCKAPRLVSQLHFTSWPDFGVPFT
 .|.. |....  .|. ..|||.. .|   ||| .|.|    .   . |. ||. . .   |  ..   .  .| .  |  . | .  .. |..   |  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpel

PIGMLKFLKKVKTLNPVhagpiVVHCSAGVGRTGTFIVIDAMMA-MMH---AEQ--KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT
.. .|. || .. . ..     |||||.|.||.  | |.. .   |..     .  ..|  ...  .|..|.. ..| ||  |    .|.. |   .
areilnilkvarnsksl.....vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 331-394 9.4e-19 61.6 In-house 1-64 (69) alignment 
Range on Protein: 331-394
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
.|||||.| ||||||| |   || . .|. ||.|. |  .|  || ||  ...| ||. || | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_CG42327_pd Subfamily CG42327 328-394 3.2e-18 60.4 In-house 247-314 (319) alignment 
Range on Protein: 328-394
Range on HMM: 247-314/319.0
AGPIVVHCSAGVGRTGTFIVIDAMMAMMHAE-QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
 ||.||||| ||||||. |  |  .  .    . ||. . || .|..| . |.|  || |||. | ||
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 332-394 6.7e-18 58.8 In-house 1-63 (69) alignment 
Range on Protein: 332-394
Range on HMM: 1-63/69.0
VVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
|||||.| ||||||| |   || . .|. ||.|. |  .|  || ||  . .| ||..|| | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 503-690 7.6e-18 59.5 In-house 39-221 (255) alignment 
Range on Protein: 503-690
Range on HMM: 39-221/255.0
LahTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG--SVTHGEITIEIKNdtLSEAISIRDFLVTLNQPQarqEEQVRVVRQFHFHGWPEIGI
|  ||. |...|   |....|||.. .| ...|| .|.|.|        ....   .   |  . .|   .|..  .     . . |. ....||.|   
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlge...kkkthtvkhysykGWiekna

PAEGKGMIDLIAAVQKQqqqtgnHPITVHCSAGAGRTGTFIALSNILE------RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
| . . .  .. .|..       ... ||||.| ||. .|.    .        .    . ||  . .. || .|.  ..|  |  |.  .| |..
Pelareilnilkvvrds......ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_eak_pd Subfamily eak 434-602 1.9e-17 57.7 In-house 39-196 (332) alignment 
Range on Protein: 434-602
Range on HMM: 39-196/332.0
TNVRIMKENMRTGNLpanmKKArVIQIIPYDFNRVILSMKRgQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ
 ... ..|  |. ..    ..  |..|.|||.. | |.  . ..   ||||| ..       .| |  .    |  ||.|. | || .||.| |  | . 
qrllsisetarleav....nrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

DKCYQYWPTEG--SVTHGEITIEIKNDTLSEAISIRDFLVtlnqpqaRQEEQVRVVRQFHFHGWPEIGIPA
.|  .|.| ..   . .| . .| |.    . .  | . .       .. ..   |  ....|| |. .| 
eksdkyfpdktreelkfGildverkefvkrniletrllel.......skGnethrvlhykvfGwtettlpk
subfamily_eak_pd Subfamily eak 154-280 2.2e-16 54.2 In-house 47-173 (332) alignment 
Range on Protein: 154-280
Range on HMM: 47-173/332.0
ANKEENREKNrYPNILPNDHSRVILSQLDGIPcSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQG-
... |. ..|   .|.|.|.  | |.     .   ||||| ..  .  .|.| .  .... |  ||.|| |||| .||.| .  | | ||  .|.||.. 
tarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

-CWTYGNIRVCVEDCVVLVDYTIRKFCIQ
  . .| . |   . |    .  |.. ..
eelkfGildverkefvkrniletrllels
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 441-549 3.2e-16 53.7 In-house 86-187 (244) alignment 
Range on Protein: 441-549
Range on HMM: 86-187/244.0
ENMRTGNLPANMKKARVIQIIPYDFNRVILSmkRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREqdkcyQYW
  |.    | |  | |    .|.||||| ||  .|     ||||||.    .   .| || ||| |  |||.|. | .   .|.|  |.| .     .||
svmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eyw

PTEGSVTHG
|    .   
pdseplewy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 328-393 4.7e-16 53.5 In-house 228-293 (297) alignment 
Range on Protein: 328-393
Range on HMM: 228-293/297.0
AGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE
  ...|||||||||.|  .  |...|..  ..  ||  ..| .|.||...|||  |....|.| |.
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 618-690 9.3e-16 52.4 In-house 242-315 (319) alignment 
Range on Protein: 618-690
Range on HMM: 242-315/319.0
QQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAE-GLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
 ..  . |..|||| |.||||. ||    .....     .|. | | |.| .| . |.| ||||| |||.. . 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_hpo-7_pd Subfamily hpo-7 497-690 1.6e-15 51.8 In-house 42-227 (263) alignment 
Range on Protein: 497-690
Range on HMM: 42-227/263.0
IatqgpLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEG--SVTHGEITIEIKNDTLSEAISIRDFLVTLNQpqarqEEQVRVVRQFHFHG
.     |  |.. |...|   |....|||.. .| ...|| .|.|.|        ....   .      .  ...| ||..       ... |... . |
l.....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.....Kkkthtvkhysykg

WPEIGIPAEGKGMIDLIAAVQKQqqqtgnHPITVHCSAGAGRTGTFIALSNILE------RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
|.|   | . . .. .. ....       ... ||||.| ||.  |     .        .    . ||  . .. || .|.  ..|  |  |   .| |
Wiekndpelareilnilkvarns......kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

FI
|.
fv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 158-251 4.1e-15 50.1 In-house 33-125 (332) alignment 
Range on Protein: 158-251
Range on HMM: 33-125/332.0
ENREKNRYPNILPNDHSRVILSQLDGIpcSDYINASYIDGYKEKNKFIAAQGPKQE-TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ
.| . || | .   ||||| |.  ||    |. |||..||| .|. .| || | .. |   ||||| |.| . |... .. |... |.     |.
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 628-684 7.9e-15 49.0 In-house 2-58 (69) alignment 
Range on Protein: 628-684
Range on HMM: 2-58/69.0
VHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYK
||||.|.||||||||.   . |.|.| |.|.|  |. .|  || ||   ..| | . 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 627-683 8.6e-15 48.9 In-house 2-58 (69) alignment 
Range on Protein: 627-683
Range on HMM: 2-58/69.0
TVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY
 ||||.|.||||||||.   . |.|.| |.|.|  |. .|  || ||    .| | .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifih
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 607-688 1.6e-14 48.4 In-house 247-342 (350) alignment 
Range on Protein: 607-688
Range on HMM: 247-342/350.0
MIDLIAAVQKQqQQTGNHPITVHCSAGAGRTGTFIALSNILE---------------RVKAEgLLD-VFQAVKSLRLQRPHMVQTLEQYEFCYKVVQD
.||   | .   ..    || |||||| |||||...|  .|.                | |. . | ... |. || ||  |||.|.|. |.|. .. 
liddlfaeshl.dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisiivnelrkqrismvqnldqfifiYeallf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 403-501 2.5e-14 47.2 In-house 6-95 (95) alignment 
Range on Protein: 403-501
Range on HMM: 6-95/95.0
DVSSLEKHLQTMHGTTTHfdkiGLEEEFRKLTNVRimKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGqeyTDYINASFIDGYRQKDYFIATQG
 || .  |.  ||  . .     ...||. ..       .  .|   ||. | |...|.|||  ||.|. ||    .||||| |.||| .|. .||.||
hvsvfhshvlemhsnsdq....efdnefksismts..gapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 127-209 3.8e-14 46.7 In-house 18-95 (95) alignment 
Range on Protein: 127-209
Range on HMM: 18-95/95.0
RSADDcKQFREEFNSLPSGHiQGTFELANKEENREKNRYPNILPNDHSRVILSQLDgipCSDYINASYIDGYKEKNKFIAAQG
 |  | ..| .||.|..      ..     | |  |||. ||.| | .||.|.       |||||| ..|||  || .|||||
hsnsd.qefdnefksismts.gapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 488-559 5.3e-14 46.4 In-house 230-299 (440) alignment 
Range on Protein: 488-559
Range on HMM: 230-299/440.0
DGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEReqdKCYQYWPTE-GSVTHGEITIEIKNDT
.|| .|. ||||| ||  || ||||.. ...  ||.|| .....    |  ||| .  ||| | .|.  |   
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgse
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 130-197 7.6e-14 45.9 In-house 19-85 (440) alignment 
Range on Protein: 130-197
Range on HMM: 19-85/440.0
DDCKQFREEFNSLPSGHIQGTfELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDG
   . | .|.. ||||  | . . |.  .|. |||| |||  |||||.| .. |.| |||||||||.|
rrsrafedewsllpsglsqps.diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 450-535 3.3e-12 40.5 In-house 33-117 (332) alignment 
Range on Protein: 450-535
Range on HMM: 33-117/332.0
ANMKKARVIQIIPYDFNRVILSMKRGQEytDYINASFIDGYRQKDYFIATQGPLA-HTVEDFWRMIWEWKSHTIVMLTEVQEREQDK
 ||   |. ..  .|..|| |. . |..  |. |||..||| .|  .| .| |.  ||   ||||. | |   |... ...|... |
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 196-257 3.4e-12 40.4 In-house 230-289 (440) alignment 
Range on Protein: 196-257
Range on HMM: 230-289/440.0
DGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERkeeKCHQYWPDQ-GCWTYG
.||  || |||.| | . || ||||.| . . .||.|| .|...    |  ||| .    |.|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 474-560 6.3e-12 39.5 In-house 85-170 (349) alignment 
Range on Protein: 474-560
Range on HMM: 85-170/349.0
RGQEYTDYINASFIDGYR--QKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPtEGSvtHGEITIEIKNDTL
 .    ||||| ..   |   .  .|||| ||  ||.||...|   . . .. |.. .| . .||..||  |.|  . .||. ..|  |
dsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq.els..ysnitvklqnssl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 200-394 1.1e-11 37.9 In-house 113-308 (346) alignment 
Range on Protein: 200-394
Range on HMM: 113-308/346.0
EKNKFIAAQGPKQE---TVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNiRVCVEDCVVLVDYTIRKFCIQpQLPDGCKAPRLVSQL
 ..|.| || |. |    |.||| |.....   . ..      |.     .  ..| . |   .. ...    |    ... |.  ||.|     ..   
fehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytg.kmfinnrradvsgdpkeytie.vlpegnsdsvicqvh

HFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY
| . |  .  |   . ..|.... .. . |..  . |    | ||. .||     .  .    . ...| .  |..|||  |..  ||. ||  ...|
hhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
subfamily_eak_pd Subfamily eak 315-413 2.3e-11 37.7 In-house 225-321 (332) alignment 
Range on Protein: 315-413
Range on HMM: 225-321/332.0
KFLKKVKTLNPVHAgPIvVHCSAGVGRTGTFIVIDAMMAMMHAEQK--VDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELdvSSLEKHLQ
 .||| .   | .| || . .. |  |.|.|.||| .. .. . .|    | ... .....|   | ...|..|||...|.| |  . .|    |.|.|.
stlkkyihtppsfa.pi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl..rdlkkyle

T
.
a
subfamily_PTPDC1_pd Subfamily PTPDC1 298-389 6e-11 37.1 In-house 87-170 (182) alignment 
Range on Protein: 298-389
Range on HMM: 87-170/182.0
FTSWPDFGVPfTPIGMLKFLKKVKtlNPVHAGPIVVHCSAGVGRTGTFIVidAMmaMMHaEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
  .|.|.||. .   .|   | |.    .. | . ||| || ||||  |   ..  ...  ....  . .. .|..||. .||  |  .. .
nfgwkDygva.sleriLdivkvva..falqegkvavhChaGlGrtGvlia..cy..lvy.akrltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 593-689 1.6e-10 36.5 In-house 83-176 (194) alignment 
Range on Protein: 593-689
Range on HMM: 83-176/194.0
HG--WPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILErvkaEGLlDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF
.   .|. | .   . . . . .|..  ..  .. . ||| || |||||..|   |       |. .. .|.. .|  ||..... ...|  .| ....
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr....lgm.saeeAialfrekRpgaipnqdyleallkrykel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 616-690 1.6e-10 34.8 In-house 258-344 (349) alignment 
Range on Protein: 616-690
Range on HMM: 258-344/349.0
KQQQQTGNHPITVHCSAGAGRTGTFIALSNILE----------RVKAEGLL--DVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
.  ..    .. |||||| ||||... |  .|.          ..| . ||   .. .| .|| ||  ||| | |. ..|. .  ..
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 150-234 1.9e-10 34.8 In-house 28-117 (347) alignment 
Range on Protein: 150-234
Range on HMM: 28-117/347.0
TFELANKEENREKNRYPNILPNDHSRVILSQLD-----GIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT
 |  .. | . .|||  .   .| .||.||  .       .   |||||.|   . ....| .| |  .|| |||.||   | . .| . 
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 461-562 2.8e-10 34.6 In-house 3-91 (130) alignment 
Range on Protein: 461-562
Range on HMM: 3-91/130.0
IPYDFNRVIlsmkrgqeYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREqdkcyQYWPTEGSVTHGEITIEIKNDTL
......|.           .||||||.    .   .. || ||| |  |||.|. |     .|.|  |.| .     .|||    .   |  | .     
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

SE
 |
de
subfamily_PTPDC1_pd Subfamily PTPDC1 589-685 4.3e-10 34.3 In-house 84-171 (182) alignment 
Range on Protein: 589-685
Range on HMM: 84-171/182.0
QFHFHGWPEIGIPAEgKGMIDLIAAVQKqQQQTGnhPITVHCSAGAGRTGTFIALSNILERVkaeglLDVFQAVKSLRLQRPHMVQTLEQYEFCYKV
 ..  ||.. | ..  . ..|..  |.    | |   ..||| || ||||  ||   .  .      |.  .|.| .| .||. .|| || |.. . 
yvynfgwkDygvasl.eriLdivkvvaf.alqeg..kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 450-535 5.3e-10 33.3 In-house 36-126 (347) alignment 
Range on Protein: 450-535
Range on HMM: 36-126/347.0
ANMKKARVIQIIPYDFNRVILS-----MKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDK
 ...| |  .    |  ||.||     . | ..   ||||| |     .  .| || || .|| |||.|.   |   .| . | .. |  .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaie
0038934 (Phosphotyrosine protein) phosphatases II 291-388 6.9e-10 34.4 In-house 77-170 (194) alignment 
Range on Protein: 291-388
Range on HMM: 77-170/194.0
RLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVH-AGPIVVHCSAGVGRTGTFIVIDAMMAmmhaeQKVDVFEFVSRIRNQRPQMVQTDMQYTFIY
..  . .   .||.|.. .   .|.||. |.. .  .  | ..||| ||.|||||...   ..      .. .. | . ..|  || ....  ..  ..
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleall
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 506-690 1.9e-09 30.6 In-house 130-309 (346) alignment 
Range on Protein: 506-690
Range on HMM: 130-309/346.0
TVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGS-VTHGEITIEIKNDTLSEaiSIRDFLVTLnQPQARQEeqvRVVRQFHFH-GWPEIGIPAE
 ||||| ||.. . | . ..   .   .     .   .|     | . |. .   .|     ... . .  |.   .    |. | | |  |  .  |  
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsg..dpkeytiev.lpegnsd...svicqvhhhapwkhlqqppk

GKGMIDLIAAVQKQqQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
   .| .|     . .|  |  . |    |.||. .||     ....      .... .|... |||  |... ||   | .| |.|
tlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 188-253 1.7e-08 28.4 In-house 123-183 (244) alignment 
Range on Protein: 188-253
Range on HMM: 123-183/244.0
DYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEekchqYWPDQGC
 |||||..       ..| .| |  .|  |||.|. |..   .|.|  ..|  |     ||||   
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdsep
subfamily_CDC14_pd Subfamily CDC14 314-389 2.9e-08 27.9 In-house 253-318 (328) alignment 
Range on Protein: 314-389
Range on HMM: 253-318/328.0
LKFLKKVKTLnpvhAGPIVVHCSAGVGRTGTFIVidammAMMHAEQKVDVFEFVSRIRNQRPQMVQTdMQYTFIYQ
 |||. ...      | |.||| ||.|||||.|      . .  . ..   | .. .|  || .| .  | .|...
kkfleiaeka....eGaiavhCkaGLGrtGtLia.....cylmkhyrftaaeaiawlricrPGsvig.pqqkflee
PTEN_1 300-385 5.8e-08 27.8 In-house 101-178 (196) alignment 
Range on Protein: 300-385
Range on HMM: 101-178/196.0
SWPDFGVPfTPIGMLKFLKKVKTLNPV--HAGPIVVHCSAGVGRTGTFIvidaMMAMMHAEQkVDVFEFVSRIRNQRPQ-MVQtdmqyT
...|.|.| .   .....|...       . . ..||| ||.||.|| .    .. .|....  .. | ....| .||. ...     .
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapn.....s
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 131-199 9.1e-08 26.0 In-house 11-78 (244) alignment 
Range on Protein: 131-199
Range on HMM: 11-78/244.0
DCKQFREEFNSLpSGHIQGTF-ELANKEENREKNRYPNILPNDHSRVILSQLDgIPCSDYINASYIDGYK
| .  .||| .| | | .  .   |    |  |||| |||| |..|||||       ||||||.||.| .
deevakeefvgl.sdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq
subfamily_DSP23_pd Subfamily DSP23 620-683 1.3e-07 26.4 In-house 81-139 (148) alignment 
Range on Protein: 620-683
Range on HMM: 81-139/148.0
QTGNHPITVHCSAGAGRTGTFIALSNILERVkaeglLDVFQAVKSLRLQRPHMVQTLEQYEFCY
.  |  ..|||  | |||||..|   . ||      |   .|.  .| .||  |.|.|| .  .
eekneavsvhcllgrgrtgtmlacylvkerk.....laaaeaiaevrrlrpgsvetveqeklvr
0048567 (Phosphotyrosine protein) phosphatases II 296-384 1.8e-07 25.7 In-house 40-129 (157) alignment 
Range on Protein: 296-384
Range on HMM: 40-129/157.0
LHFTSWPDFGvPFTPIGMLKFLKKVKTLN---PVHAGPIVVHCSAGV---GRTGTFIvidAMMAMMHaeQKVDVFEFVSRIRNQRPQMVQ-TDMQY
.... . ||| |..     .| .|.. .      . ..|.|||.||    |||.|.|   .  ...|  .. .  |..  .|  || .|   | .|
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi...gcYlilh..lgftpeeaiaplrivrpgsvpfrdasy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 183-261 2.4e-07 25.1 In-house 9-82 (130) alignment 
Range on Protein: 183-261
Range on HMM: 9-82/130.0
GIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEekchqYWPDQGCWTYGNIRV
 ..  .|||||..      .... .| |  .|  |||.|. |.    .|.|  ..|  |     ||||     . . ..
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeedi
subfamily_DSP23_pd Subfamily DSP23 298-389 2.9e-07 25.2 In-house 56-140 (148) alignment 
Range on Protein: 298-389
Range on HMM: 56-140/148.0
FTSWPDFgVPFTPIGMLKFLKKVKTLNpVHAGPIVVHCSAGVGRTGTFIVIdammaMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQ
    .|.  | ..  . .|.. |.  .  ..  . |||  | |||||..        .  |.|.   | .. .|..||  |.|  |   ...
rlriddy.hppaleqvvefvrvveeae.ekneavsvhcllgrgrtgtmlac.....ylvkerklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_ptpA1_pd Subfamily ptpA1 656-690 3e-07 24.5 In-house 364-398 (418) alignment 
Range on Protein: 656-690
Range on HMM: 364-398/418.0
LDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI
...|  |  || ||| ||| |||| |||| . | |
fnlfsivlklreqrpgmvqqleqylfcyktildei
subfamily_PTEN_pd Subfamily PTEN 331-387 1.1e-06 23.8 In-house 117-172 (184) alignment 
Range on Protein: 331-387
Range on HMM: 117-172/184.0
IVVHCSAGVGRTGTFIVIdAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFI
.|||| || ||||. ||   .. ... |.. .. |. ...| .  . |.   |  ..
vvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
PTPc_motif_SM00404 328-382 1.4e-06 23.3 In-house 80-128 (140) alignment 
Range on Protein: 328-382
Range on HMM: 80-128/140.0
AGPIVVHCSAGVGRTGTFIVIDAMMAMMHaeQKVDVFEFVsriRNQRpQMVQTDM
 | ..||| ||| |..|.|.   |. .    .  ...|||   ...| ....  .
ggkvlVHCqaGvSRSatliiaYlmryrql..slaeayefv...kerR.piispnl
DSPc Dual specificity phosphatase, catalytic domain 328-381 3.4e-06 22.0 Pfam-A 73-121 (133) alignment 
Range on Protein: 328-381
Range on HMM: 73-121/133.0
AGPIVVHCSAGVGRTGTFIVIDAMMammhaEQKVDVFEFVSRIRNQRPQMVQTD
 . ..||| ||. |..|.|.   |.     ...... |... ....|.......
gkkvlVHCqaGisRSatliiaYlmk.....tknlslneAyefvkerrskispna
DSPc Dual specificity phosphatase, catalytic domain 328-381 3.4e-06 22.0 In-house 73-121 (133) alignment 
Range on Protein: 328-381
Range on HMM: 73-121/133.0
AGPIVVHCSAGVGRTGTFIVIDAMMammhaEQKVDVFEFVSRIRNQRPQMVQTD
 . ..||| ||. |..|.|.   |.     ...... |... ....|.......
gkkvlVHCqaGisRSatliiaYlmk.....tknlslneAyefvkerrskispna
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 154-250 4.8e-06 19.6 In-house 22-86 (169) alignment 
Range on Protein: 154-250
Range on HMM: 22-86/169.0
ANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINAsyidgykeknkfiaaqgpkqetvndfwRMVWEQKSATIVMLTNLKERKeekchQYWPD
|.   |  |||    |   | || | ..     ||||||                           ||.||  .. ||.| .  ..      ..||.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 154-250 6e-06 19.2 In-house 21-85 (169) alignment 
Range on Protein: 154-250
Range on HMM: 21-85/169.0
ANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINAsyidgykeknkfiaaqgpkqetvndfwRMVWEQKSATIVMLTNLKERKeekchQYWPD
|.   |  |||    |   | || | ..     ||||||                           ||.||  .. ||.| .  ..      ..||.
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpe
subfamily_CDC14_pd Subfamily CDC14 624-683 6.5e-06 20.2 In-house 264-317 (328) alignment 
Range on Protein: 624-683
Range on HMM: 264-317/328.0
HPITVHCSAGAGRTGTFIALsNILERVKaeglLDVFQAVKSLRLQRPHMVQTLeQYEFCY
  |.||| || |||||.||   .... .    .   .|.  ||. || .| .  | .|..
GaiavhCkaGLGrtGtLiac.ylmkhyr....ftaaeaiawlricrPGsvigp.qqkfle
subfamily_DSP19_pd Subfamily DSP19 315-377 6.7e-06 20.5 In-house 80-133 (152) alignment 
Range on Protein: 315-377
Range on HMM: 80-133/152.0
KFLKKVKTLNpvhaGPIVVHCSAGVGRTGTFiVIDAMMAmmhaEQKVDVFEFVSRIRNQRPQM
.|...... .    | ..|||.||| |. .. ||  .|.    ...... | .. .|..|| .
dFieearskd....gavlvHCnAGvSRsasv.viaylmk....keelsleealelvrearpci
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 445-489 6.9e-06 19.6 In-house 41-85 (440) alignment 
Range on Protein: 445-489
Range on HMM: 41-85/440.0
TGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDG
  .|| |  | |  .|. ||..||.|   .|   .||||||.|.|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying