Gene PTPRC in Homo sapiens

Synonym: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, RP11-553K8.4, PTPRC

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRC
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP095_AA protein Get Run
HsapP095_AA_635-914 phosphatase_domain Get Run
HsapP095_AA_926-1230 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 631-991 1.6e-134 444.7 In-house 3-361 (564) alignment 
Range on Protein: 631-991
Range on HMM: 3-361/564.0
EPIHADILLETYKRKIADEGRLFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRD
.||. . | | ...  |...  |  |...| .  ..|....|.|| |..|||| .|..|| .|| ||...|| ||.|||||.|||......|||.|||  
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMeEgTRAFGDVVVKINQHKRCPDYIIQKLNIvNKKEKATGREVTHIQFTSWPDHGVPEDPHL
||..|||||.|||. ..|||.|..|| ...||..|||.  . |  .|...|.......  ||.| .... .||..   |||.. .||||||||||| .  
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesats

LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLH
||.|.|.|.| ..  .||||||||||||||||.| |||||| ...|..||.|.|| .||.||  ||| | ||| ||.|..|. ..|.|||. ..|.  |.
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

NMKKRDPPSEPSPLEAEFQRLPSY--RSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHEL
.... .. .| . ||.||||| .      . .  .....|| ||| ||.......|| |... 
kLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsair
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 643-951 3.2e-105 346.7 In-house 11-318 (318) alignment 
Range on Protein: 643-951
Range on HMM: 11-318/318.0
KRKIADEGRL-FLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIW
 |..  .|.| . .|.. . |. ...   .. .| |..||||..||.||  ||.|....|. ||.||||.||||... ..|||||.|  ||..|||||.|
vrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

EQKATVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEkATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAF
||...||||.|..||  ..|.. ||||  .|.|..|..||........ ||....... ...|    |.|   ..|||||.||||..  ||.| |.|.. 
eqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvska

S-NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSE
  .   |||||||||||||||..| .|..|| ..||. |||...| .||.|| ||||.| ||..|...|.|. . |.|||. |.|.  .......|| | 
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesg

PSPLEAEFQRL
 ....||||||
ttemdaefqrl
subfamily_PTPRA_pd Subfamily PTPRA 631-948 4.8e-105 346.1 In-house 12-330 (330) alignment 
Range on Protein: 631-948
Range on HMM: 12-330/330.0
EPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRD
 |.  . | |  ....||. .||  ||...|    .  .. | |  |..|||.|.|||||..|| ||...|   |.|||||.|||.||  |.||||||..
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK---EKATGREVTHIQFTSWPDHGVPED
|||.||||||||||.. |||.|  .| ...||| |||.  ||. ..|.. |...... . || ..|. . ..    .. . | |. . |||||| ||| .
etvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP
|  .||| ..|..  .  .||||||||||||||||.| .||.|| ..||.||||.. | .|| ||. ||| . || .|...| ||  .|.||...| |  
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

YLHNMKKRDPPSEPSPLEAEF
.|...... .  .   || ||
hlqklynkitgtdkigleeef
0051299 (Phosphotyrosine protein) phosphatases II 632-912 4.7e-103 339.8 In-house 4-285 (288) alignment 
Range on Protein: 632-912
Range on HMM: 4-285/288.0
PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE
.|... ||.......|.   ..|.||. ..... ..... |..| |..||||.||||||..|| || ..|. ||.|||||||||.. .||.||.||| ..
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK---EKATGREVTHIQFTSWPDHGVPEDP
||.|||||.|||. .||||.|...| .|.||| |||.  .|.  .||..|..   . ..||.. .| ..|..    . . |.|||...|.|||||||..|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

HLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
 |||.. |.|. . .  .||.|||||||||||||.| .| .|| ||.|..|||...| .||.||. ||| . ||.....||.||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 617-918 8.8e-102 335.8 In-house 10-304 (308) alignment 
Range on Protein: 617-918
Range on HMM: 10-304/308.0
ELVERDDEKQLMNVEPIHADILLETYKRkiADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELseingDAGSNYINASYIDGF
||.   |.. |....... . ||. ...  |..  |. .||. ...|.  .... |..| |..||||.||||||..|| |     | ||.||||||.||.
elllfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgy

--KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEE-GTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTH
  | |||.||.||| ..||.|||||.|||. .||||.|...| .|.|||.|||.... |.. .|...|..   . ..||.. .| ..|.... . |.|||
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvth

IQFTSWPDHGVPEDPHLLLKLRRRVNAFSnfFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
...|.|||||||..|  ||.. ..|. .    .||||||||||||||||.| .| .|| ||.|..|||...| |||.||. ||| . ||.....||.|| 
fhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

QFGET
.. .|
klklt
0040438 (Phosphotyrosine protein) phosphatases II 641-951 5.2e-101 333.3 In-house 8-314 (317) alignment 
Range on Protein: 641-951
Range on HMM: 8-314/317.0
TYKRKIADEGRLFLAEFQSIPRVFSKfPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI
.... ..   ...| ||. .....   ....|..| |..||||.||||||..|| || ..|| .|.||||||.||....||.||.||| ..||.|||||.
alldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WEQKATVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKkEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
|||. |||||.|..|| .|.|||.|||.  ..|  .||..|.. . . ...... .| .... .. . |.|||...|.|||||||..| |||.. ..|..
weqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavre

FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSE
. .  .||..||||||||||||.|... ||| || |..|||.  | .||.||. .|| ..||. ...|| || ....| ...|||. .|....  .....
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

PSPLEAEFQRL
... | |...|
vklkekelkll
subfamily_PTPRB_pd Subfamily PTPRB 631-914 3e-100 330.0 In-house 5-286 (293) alignment 
Range on Protein: 631-914
Range on HMM: 5-286/293.0
EPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRD
.||... . | .|.. ||.   |  |....  | ..  .| |... |..|||| .|||||..||.|.......||.||||.||.|.. ||..||.|||  
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTrAFGDVVVKINQHKRCPDYIIQKLNIVNkkeKATGREVTHIQFTSWPDHGVPEDPHL
|||||||||.||.|...|||.|.. |. . || ||||. || . ..||. |.......  |..|..|.| .   . . |.|.. .|||||||||||... 
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektkt

LLKLRRRVNAFS--NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
||.. |.|.     .  ..|||||||||||||||.| .| .|. .| |. ||..| |..||..|.|.|| |.||| |||..... .
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 634-949 5.1e-100 329.6 In-house 6-319 (319) alignment 
Range on Protein: 634-949
Range on HMM: 6-319/319.0
HADILLETYKRKIADEGRLFLAEFQSIPRVFSKfPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV
. . | | .|.  .   .|.  ||. .    ..  ...| |. |..|||| .||.||  || |||..|  ||.|||||.|||..| .|.||.|.| ..|.
evqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

DDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEegTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLK
.|||||.||... ..||.|.  |  . |. .|||. .     .| ..|.......  ||||.||.. .|...   |||.| |.|.||||.|||.  .||.
edfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld

LRRRV-NAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNM
| .|. .. ..  |||||||||||||||||.| .||||| .. |. .||. .| .|| || .||| ..||..|..||.|. ..|.||... .|.  |...
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkql

KKRDPPSEPSPLEAEFQ
..... .  . || |||
aekvadtgetglerefq
0046845 (Phosphotyrosine protein) phosphatases II 653-920 3.4e-98 323.8 In-house 2-281 (284) alignment 
Range on Protein: 653-920
Range on HMM: 2-281/284.0
FLAEFQSIPRVFSKF--PIKEARKPFNQNKNRYVDILPYDYNRVELSEINGD-AGSNYINASYIDGF-----KEPRKYIAAQGPRDETVDDFWRMIWEQK
. .||. ..... |.  ... |..| |..||||.||||||..|| |. ..||  .|.||||||.||.     . ..|.||.||| ..||.|||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

ATVIVMVTRCEEGNRNKCAEYWPSMeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSN-
..||||.|...| .|.||| |||.. ...  .||. |..   . ..||.. .| ..|.. .   |.|||...|||||||||..|  ||.. | |. . . 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-FFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEN---KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEV
   .||||||||||||||||.| .| .|| ||.|.   .|||...| .||.||. ||| ..||.....||.|| ... | .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0036941 (Phosphotyrosine protein) phosphatases II 652-928 2.1e-96 318.0 In-house 14-292 (297) alignment 
Range on Protein: 652-928
Range on HMM: 14-292/297.0
LFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELseinGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV
|.| ||.......  .... |..| |..|||| ||||||..|| |    .| ||.||||||.||.. .||.||.||| ..||.|||||.|||. |||||.
lllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKR--CPDYIIQKLNIVNKKEKaTGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF--FSG
|...| .|.|||.|||. |...  .||..|.    .   ..||.. .| .......   |.|||...|.||||||||.|  ||.. ..|. . .    .|
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PIVVHCSAGVGRTGTYIGIDAMLEGLE---AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY
|..|||||||||.||.|..| ||. ||    |..||.. .| |||.||. .|| . ||. ...|| |. ....| ..|..|. .
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
0043336 (Phosphotyrosine protein) phosphatases II 638-912 1e-94 312.4 In-house 7-276 (278) alignment 
Range on Protein: 638-912
Range on HMM: 7-276/278.0
LLETYKRKIADEGRLFLAEFQSIPRVFSkFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFW
||...... ... .|.|.||.......  .... |..| |..||||.||||||..|| || ..|| .|.||||||.||.. |||.||.||| .|||.|||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMIWEQKATVIVMVTRCEEGNRNKCAEYWPsmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHLLLKLRRR
||.||.. |.|||.|...| .|.|||.|||   .|.  .||..|.    . ..||.. .|...|.... . |.|||.....||||||||.. |||.. ..
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflka

VNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
|. . .  .||..||||||||||||.|... .|| || | .||..  | .||.||. .|| . ||. ...|| ||
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Ptp69D_pd Subfamily Ptp69D 632-927 1.4e-94 311.7 In-house 3-300 (307) alignment 
Range on Protein: 632-927
Range on HMM: 3-300/307.0
PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE
.|. | | |..| .  |   ... |...... ...   | . |  |. |||| || ..| .|| |..|||.. |.|||||.| |.|| .|.||||.| ..
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMeeGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----TGREVTHIQFTSWPDHGVPED
|..||||||.||. |.|||..  .| ||.||| |||     .  .||..||. ......||||..|.. .|||..      |.|.  ..|.|.|  ||| 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP
.. |||| ..|.   ..  .||||||||||||.|... .| .|. |.||.|||..  | .||.|| |.||  .||. ...||..|...|.|.... .|. 
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled
0045450 (Phosphotyrosine protein) phosphatases II 632-912 2.2e-94 311.9 In-house 8-303 (307) alignment 
Range on Protein: 632-912
Range on HMM: 8-303/307.0
PIHADILLETYKRKIADEGRLFLAEFQSIPRVFS--KFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGD-AGSNYINASYI--------DGFKEPR
.| | .||  ......|   ..|.||.....|     .....|..| |..||||.||||||..|| || ..|.  .|.||||||.        ||.. .|
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWP
|.||.||| .|||.|||||.|||. |||||.|...| .|.|||.|||.  ...  .|...|.    . ...|.. .|.. .....  .|.|||...|.||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEDPHLLLKLRRRVNAFSNF--FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK---VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
|||||...  ||.. ..|... .    .||..||||||||||||.|... ||..||.|..   ||..  | .||.||. .|| . ||. ...|| |.
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0047943 (Phosphotyrosine protein) phosphatases II 651-912 4.7e-94 310.1 In-house 12-271 (273) alignment 
Range on Protein: 651-912
Range on HMM: 12-271/273.0
RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELseinGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
.|.|.||. .....  .... |..| |..|||| ||||||..|| |    || ||.||||||.||.. .||.||.||| ..||.|||||.|||...||||
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

VTRCEEGNRNKCAEYWPSMEEG-TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAtGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF--FSG
.|...| .|.||| |||. ... .  .|.. |..  .. ..||.. .| ..|.. .   |.|||...|.|||||||...  ||.. . |. . .    .|
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsng

PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
|.|||||||||||||.| .| .|. ||.|..|||. .| .||.||. ||| . ||.....||.||
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 626-916 1.2e-92 305.8 In-house 7-292 (297) alignment 
Range on Protein: 626-916
Range on HMM: 7-292/297.0
QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSkfPIKEARKPFNQNKNRYVDILPYDYNRVELSEING-DAGSNYINASYIDGFKE-PRKYI
 |....||. ..|   .... |..  |.|.||.......   ....|..| |..||||.||||||..|| |. ..| | .|.||||||.||..  .||.|
allesipiplsvldlllllekansktllllefeellslkp..dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

AAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRnKCAEYWPSMEEgtrAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKatgREVTHIQFTSWPDHG
|.||| .|||.|||||.|||. |||||.|...| .| |||.|||. ..    .||..|.  . . ...|.. .|...|..|    |.|||.|.|.|||||
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhg

VPEDPHLLLKLRRRVNAFSNF--FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFG
||... |||.. . |. . .    .||..||||||||||||.|... ||| || | .|||.  | .||.||. .|| . ||. ...||.|. ...
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 654-913 9.3e-91 299.2 In-house 3-262 (263) alignment 
Range on Protein: 654-913
Range on HMM: 3-262/263.0
LAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR
 .||... .  |. ...||.|. |..|||| .||||| .||.|...... ||.||||.||.| ....||||.||| ..||.|||||.||.| ..|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCP-DYIIQKLNIVNKKEkATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVH
.|| ...||..|||. ..|.  ||.. ||. . . .. ..|...|.. ....  . |.||..|...|||||||.... .|.| | |.  ..  |||||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
||||||||||.. || .|. ||.|.|||.   | .|| ||. ||| ..||. |..|..|| 
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 654-913 9.3e-91 299.2 In-house 3-262 (263) alignment 
Range on Protein: 654-913
Range on HMM: 3-262/263.0
LAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR
 .||... .  |. ...||.|. |..|||| .||||| .||.|...... ||.||||.||.| ....||||.||| ..||.|||||.||.| ..|||.|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCP-DYIIQKLNIVNKKEkATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVH
.|| ...||..|||. ..|.  ||.. ||. . . .. ..|...|.. ....  . |.||..|...|||||||.... .|.| | |.  ..  |||||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
||||||||||.. || .|. ||.|.|||.   | .|| ||. ||| ..||. |..|..|| 
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 649-920 7.7e-90 296.1 In-house 25-297 (298) alignment 
Range on Protein: 649-920
Range on HMM: 25-297/298.0
EGRLFLAEFQSIPRVFS---KFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA
.   . .||| . .| |   ..  . |||| |..|||| ||...|. || |.....|  |.|||||.....|.   .||.|.|  ||| |||||..|...
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi

TVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKaTGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAfSNFF
..|||.|  || .. |. .|||.  ||.. .|.. |.. ....  |.|..||.. .|||. . ||| ...||||||.||||  . .|.|.|.|.| |.  
gtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqq

SG--PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEV
.|  |..|.|||||||.||.| ||..|| ...|..|||. .|  ||..|. .|| |.||. |..|  |. . ...|.
agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 641-912 1.8e-87 288.0 In-house 11-278 (288) alignment 
Range on Protein: 641-912
Range on HMM: 11-278/288.0
TYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI
  ..| |..   |  |..|.. . ..   . .|.. |..|||| .|||||..||.| . .  ||..||||||||| |. .||||.|||  .||.|||...
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGtRAFGDVVVKINQHKRCPDYIIQKLNIVnkkEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
.|.|.. |||.|   ||...|| ||||. ..  . .|.| |.. ..|   |.. .|| ..    | | .|.|. |...||||||||. . ||.|.| |. 
yenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkv

FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
 ..  .|||.||||||||||||.| .||... .|.|...|| | | |||.|| |.||.. ||. |...|.. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 648-934 1.6e-86 285.2 In-house 19-304 (305) alignment 
Range on Protein: 648-934
Range on HMM: 19-304/305.0
DEGRLFLAEFQSIPRVfsKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV
.. . . |...|...   . .|.  .|  |..|||...| ..| .|. |.| . .  |.||||||.||.|.  |||.|||| ..||.||||.|.| | ..
ysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG
|||.|.  ||...||  |||  .  .. ||...|.....|  .|||. ||.| ...|.  .| |.. |.|.|||||||. .  ||.| .||.   .   |
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK
 |..|||||||||||..| .| .|| |..|. |||.... .||..|  |||  .||  .|.|| |. . |.|..  | |.  .. .||
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklkk
subfamily_PTPRG_pd Subfamily PTPRG 649-927 3.2e-86 284.7 In-house 17-301 (563) alignment 
Range on Protein: 649-927
Range on HMM: 17-301/563.0
EGRLFLAEFQSI--PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGS-NYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA
.   | .||...    . ...... ..|| |..||||..|..||  ||.||.. |  .. .||||.||||..  ...||.|||  .|.||||||||||..
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TVIVMVTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN---KKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
..|||.|  .| .|.||  |||.  ...  .| . |.. ....   | ...| | |   ||.|   | ..|.. ..|.|||||||| .   |.  .. .|
aiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa

FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP
  .   |||||||||||||||||| .|..|. ...||.|.|.| . ..| ||  .|| | ||| .|.||.|  . .|||.  .... 
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
0040439 (Phosphotyrosine protein) phosphatases II 668-912 3.2e-85 281.0 In-house 2-245 (249) alignment 
Range on Protein: 668-912
Range on HMM: 2-245/249.0
PIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWP
....|..| |..||||.||||||..|| || ..|  .|.|||||||||.. .|..||.||| .|||.|||||.||.. |||||.|...| .|.|||.|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKkEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF--FSGPIVVHCSAGVGRTGTYIG
.  .|.  .||..|.  . . ..||.. .| ..|. .. . |.|.|||.|.|||||||...  ||.. ..|. . .    .||..||||||||||||.|.
l..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
.. ||| || |..||.. .| .||.||. .|| . ||. ...|| |.
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 677-911 3.7e-85 280.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 677-911
Range on HMM: 1-235/235.0
NQNKNRYVDILPYDYNRVELseiNGDAG-SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA
|..|||| |||||| .||.|   .|. | |.||||.|..|.||..|.||.||| ..|..|||||.|..| .||||.|..|| .|.|||.|||. ||..  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDVVVKIN-QHK-RCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL
.||. |..  . |  . .|...||.. .|||.   |||.....|.||||||||.|. ||.| |.|.  ..  |||.|||||||||||||.. .|..|| |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
|||..|||. .| .||.||. ||| ..||| ...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 677-911 3.7e-85 280.5 In-house 1-235 (235) alignment 
Range on Protein: 677-911
Range on HMM: 1-235/235.0
NQNKNRYVDILPYDYNRVELseiNGDAG-SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA
|..|||| |||||| .||.|   .|. | |.||||.|..|.||..|.||.||| ..|..|||||.|..| .||||.|..|| .|.|||.|||. ||..  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDVVVKIN-QHK-RCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL
.||. |..  . |  . .|...||.. .|||.   |||.....|.||||||||.|. ||.| |.|.  ..  |||.|||||||||||||.. .|..|| |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
|||..|||. .| .||.||. ||| ..||| ...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 628-933 2.9e-84 278.1 In-house 11-311 (319) alignment 
Range on Protein: 628-933
Range on HMM: 11-311/319.0
MNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKF-PIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQ
. |....|  .  . |... |. . . .||. ....  .    . |  . |..|||...||..| |.| |  ..|  .|.|||||...|.. . ||||||
vavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

GPRDETVDDFWRMIWEQKATVIVMVTrceegnRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPE
||.|.|..||||||||.... ||..|      ..||..|||   ..    .   ||..  . . .|....... .. ..   |..|   |  |||.|||.
GPldntladfWrmiweyncstivllt......kdkcsqywpl..kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpd

DPHLLLKLRRRVNAFSNFFS--GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE
 |  |..| ..|. . .      .|||||||||||||.|| .|..|. .. |..|||| .|  ||.||  .||  .|| .|. ||.| . || ..| . .
ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampd

LHPYLHNMK
.  ||... 
fpayleels
subfamily_PTPRK_pd Subfamily PTPRK 650-949 3.9e-84 277.2 In-house 21-313 (314) alignment 
Range on Protein: 650-949
Range on HMM: 21-313/314.0
GRLFLAEFQSIPRVfskfpIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIV
|  |  |..|..          |.|  |..|||. |||.||  || |  |.||. |.||||..||..| |...|..||| .||| ||||........ ||
gygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MVTRCEEGNRNKCAEYWPsmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN-KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGP
|.|   |  | || .|||   | |. .||. |.. . .   ..... ... . .. .   ||| ..||..||||.||   . |||| |||.. ..   |.
mltelvevgrvkClkyWP...edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEF
|||||||| |||||.| || .|. .| |. |||.  | .|| ..  ||..| ||..|.....|    ||| .  ||..    .... || .. | |. ||
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef

Q
|
q
0045098 (Phosphotyrosine protein) phosphatases II 651-915 9.4e-84 276.3 In-house 7-274 (278) alignment 
Range on Protein: 651-915
Range on HMM: 7-274/278.0
RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVElseingdagsNYINASYIDGFkePRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
  .| ||. ... ..   | .| .. |..||||.||||||..||           .|||||||||.  |.|.||.||| ..||.|||||.||.. |||||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTRCEEGNRNKCAEYWPSmeEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK---KEKATGREVTHIQFTSWPDHGVPEDP--HLLLKLRRRVNAFSNF-
.|...|..|.|||.|||.  .|.  .||..|.. . ....||.. .|...|    .|  . |.|||.....|||||||..|    .|.| ...... .. 
ltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------FSGPIVVHCSAGVGRTGTYIGIDAMLEGLeaENKVDVYGYVVKLRRQRCL-MVQVEAQYILIHQALVEYNQF
             .||..||||||||||||..... ||| |  |..||.. .| .||.||.  .|| . ||. ....|.|. . 
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0050432 (Phosphotyrosine protein) phosphatases II 923-1227 9.4e-84 276.6 In-house 23-297 (308) alignment 
Range on Protein: 923-1227
Range on HMM: 23-297/308.0
SELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelemskesehdsdessdddsdsEEPSKYINASF
|. ...|. .|. ... ... ||.||..|.|.  ...  .....|||.||| ....|||..|| |                        .|.| |||||.
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl........................degsdYInAsy

IMSY--WKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE----GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRT
.. |  ..|  .||.||||..|..|||.|... .|.||||||.|   ..| ||||| .    | ..||.. | |..... ..||.|..||.... ..|||
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrt

VYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqKNssegnkhhksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFE
|....||||   . | .|..|..... |...|  ..           | ..||..|   || |.||. |||  |.|  ||.|..|| ||. ||||| |.|
vthfhytnWpdhgvPpspeilldflelvrksl..pg..........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

QYQFLYDVIAS
||.|||.... 
qylflyralle
0051299 (Phosphotyrosine protein) phosphatases II 916-1226 3.2e-83 274.8 In-house 1-283 (288) alignment 
Range on Protein: 916-1226
Range on HMM: 1-283/288.0
GETEVNLSELHPYLHNMKkrdpPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdessddDSDSEEPS
|.||....||. ......    .. .. |..||..|.|.  ..|..... .||..|||.|...|||..|| |.                   . |..|.|
gdteisveellklvlkll....angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLs...................vldgvegs

KYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS----K
 |||||.|  |...  .||.||||..|..|||.|... .|.||||||.|   ..| |||||  .|..||||| | |..... ..||.|..|...     .
dYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldg

RKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPqknssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPG
 . ||||....||||   . |  |..|..... |...|.          ... | ..||..|   || |.||. |||  |.|..||....|| ||. |||
dgesrtvthfhytnwpdhgvpdspellldflrlvrkala..........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg

MVSTFEQYQFLYDVIA
|| |.|||.|.|....
mvqtpeqyrfvyeall
Y_phosphatase Protein-tyrosine phosphatase 968-1226 4.5e-83 273.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 968-1226
Range on HMM: 1-234/235.0
NKSKNRNSNVIPYDYNRVPLkhelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHG
||.|||.....||| .|| |                     ..||.||.||||.....|.... .||.|||||.||.|||.|..|.|||||||||.|.  
nkkknRykdilpydktrvkl.....................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek

DQEICAQYWG---EGKQTYGDIEVDLK-DTD-KSSTYTLRVFELRHSKRKD-SRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqknssegnkHHK
..| |||||    |...|||||.| || ..  ... ||||..||...|... .|.|.|..||||  ...|..||.|...|. |...           ..|
grekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eak

STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
|.|...|| .|...||.|.||  |||..|.|| ||..|.|| ||| |||||...|||.|||..|.
sgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 968-1226 4.5e-83 273.6 In-house 1-234 (235) alignment 
Range on Protein: 968-1226
Range on HMM: 1-234/235.0
NKSKNRNSNVIPYDYNRVPLkhelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHG
||.|||.....||| .|| |                     ..||.||.||||.....|.... .||.|||||.||.|||.|..|.|||||||||.|.  
nkkknRykdilpydktrvkl.....................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek

DQEICAQYWG---EGKQTYGDIEVDLK-DTD-KSSTYTLRVFELRHSKRKD-SRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqknssegnkHHK
..| |||||    |...|||||.| || ..  ... ||||..||...|... .|.|.|..||||  ...|..||.|...|. |...           ..|
grekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eak

STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
|.|...|| .|...||.|.||  |||..|.|| ||..|.|| ||| |||||...|||.|||..|.
sgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 670-912 6.5e-83 273.1 In-house 2-242 (245) alignment 
Range on Protein: 670-912
Range on HMM: 2-242/245.0
KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSm
. |..| |..||||.||||||..|| ||...|| .|.||||||.||.. ..|.||.||| .|||.|||||.||.. |.|||.|..|| .|.|||.|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

eEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNkKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSN-FFSGPIVVHCSAGVGRTGTYIGIDA
 ...  .||..|.    . ..||.. .|...| . .   |||.|.....|||||||... |||.. ..|. . .   .||..||||||||||||.|... 
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
||| ||.| .|...  | .||.||. .|| . ||. ...|| |.
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 672-913 2.9e-82 270.6 In-house 4-242 (250) alignment 
Range on Protein: 672-913
Range on HMM: 4-242/250.0
ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNkCAEYWPSmeE
|.|| |..|||| ||...|  || | . .||  |.|||||...|..| . .||.|||  .|. |||||..|.|...|||.|  .| ... . .|||   |
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..e

GTRAFGDVVVKINQHKRCPDYIIQKLNiVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF-FSGPIVVHCSAGVGRTGTYIGIDAML
... .||| |.. ...   ||...||  . |..||  | | ...|..||| ||||  .  |.|...|.|  .   ..|..|.|||||||.|..| |||.|
kaekyGdvtvsllskeefadytkrklk.lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
| |. |..|||. .. .||..|  .|. ..||. ..... .. 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
DSPc_SM00195 944-1228 4.6e-81 267.4 In-house 2-261 (263) alignment 
Range on Protein: 944-1228
Range on HMM: 2-261/263.0
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMskesehdsdessdddsdseEPSKYINASFIMSYWKPEVMIAAQGPLKETI
|..||..| ...|... . .....|||||| .|..||| .|| ||.| .                    |.|.||||..|  ..|.. .||.||||..|.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk...................egsdYINAnyikgankkkkyIatQgPlpstv

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG---KQTYGDIEVDLKDTDKSS-TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELIS
 |||.|....|||.|||||| .  ..| |..|| |    |.|.|.|.| |....| .  ..||..||.. .....|.|.||||.||  ...| ..|....
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

MIQVVKQKLPQKnssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAST
....||..  ..          |.|...|| .| ..||.|...  .|.. |.|. ||||..||.||| |||||.|.|||.|.|..|.  
llravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 944-1228 4.6e-81 267.4 In-house 2-261 (263) alignment 
Range on Protein: 944-1228
Range on HMM: 2-261/263.0
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMskesehdsdessdddsdseEPSKYINASFIMSYWKPEVMIAAQGPLKETI
|..||..| ...|... . .....|||||| .|..||| .|| ||.| .                    |.|.||||..|  ..|.. .||.||||..|.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk...................egsdYINAnyikgankkkkyIatQgPlpstv

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG---KQTYGDIEVDLKDTDKSS-TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELIS
 |||.|....|||.|||||| .  ..| |..|| |    |.|.|.|.| |....| .  ..||..||.. .....|.|.||||.||  ...| ..|....
edFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle

MIQVVKQKLPQKnssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAST
....||..  ..          |.|...|| .| ..||.|...  .|.. |.|. ||||..||.||| |||||.|.|||.|.|..|.  
llravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN9_pd Subfamily PTPN9 668-914 1.2e-80 265.8 In-house 33-291 (297) alignment 
Range on Protein: 668-914
Range on HMM: 33-291/297.0
PIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWP
 .. .... | .|||| |.| ||  || |.....|  |.||||...||.|... .||.||| ..||.|||||.|||.. ||||.||..|  | ||..|||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

SMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF-------------FSGPIVVHCS
. || .  |||. |.  . .   || ...|.| | |.. . |.||| ||.||||.|||.. . ||.... |                      |||||||
leeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcs

AGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
||.|||||.| .|  |. || ...|||   | .|| ||  ..|.. || . ..|..|| .
aGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 674-933 1.3e-80 265.9 In-house 22-275 (284) alignment 
Range on Protein: 674-933
Range on HMM: 22-275/284.0
KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTrceegnRNKCAEYWPSmeEGT
 . |..|||...||..| |.| |  . |  .|.|||||.| |.. . ||||.|||.|.|..||||||||.... ||..|      ..||..|||   .. 
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl..kiv

RAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPIVVHCSAGVGRTGTYIGIDAMLE
   .   ||..  . . .|....... .. ..   |...   |  |||.|||. |  |..| ..|. ...      .|||||||||||||.|| .|..|.
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK
 .. |..|||| .| .||.||  .||  .|| .|. ||.| . || ..| | ..  ||... 
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_PTPN12_pd Subfamily PTPN12 665-914 4.8e-80 263.5 In-house 28-278 (290) alignment 
Range on Protein: 665-914
Range on HMM: 28-278/290.0
SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAE
.... ....|. |..|||| ||||||..|||||.|... ||.||||..| | ... .|||||||  .|.|||||||||.. ...||. |  | ...||. 
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPSMEEGTRAFGDVVVKINQHKRCP-DYIIQKLNIVNKKEKatgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY
|||.  | .  ||.. |. ...|..  |..|. |.. ..||.   |.|. ...|.|||||||. .. ||.| . |. . .  . |.||||||||||||| 
YWpeegeeelefgefevtleeekavdddflirtLkveaqkes...rkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

IGIDAMLEGLEAEN---KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
| || . | |.||.   ..||.  |..||.||  .|| . || |...|..|. |
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 643-912 7e-80 263.1 In-house 7-275 (281) alignment 
Range on Protein: 643-912
Range on HMM: 7-275/281.0
KRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE
|.. ... . |  |....  .  . . . .... |..||||..|  ||  ||.... . .  ..||||....|.|....|||.|||  .....||.|.||
kqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

QKATVIVMVTRCEEGNRNKCAEYWPsMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIvnKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS
||...||||||  |... ||  |||  .. .  .|||.|| ..... . || .|...  ..|..  |||.....|.|||||||.... ||. |. |. ..
qkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklt

NF-FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAE-NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
.     |.|.|||||||||||||..| ... .||| ...||   | .||..| ||||  .||  ...|....
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_PTPN6_pd Subfamily PTPN6 656-915 1.3e-79 262.3 In-house 31-299 (306) alignment 
Range on Protein: 656-915
Range on HMM: 31-299/306.0
EFQSIPR--VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSeINGDAGSNYINASYIDGF--KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV
||... .  . ...  ||..|| |..||||  |||.| .|| |.  .. .||.||||.||..   .. ..|||.||  ..|| |||||.|.....||||.
efeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmt

TRCEEGNRNKCAEYWPSMEEGTRaFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS----G
|.  | ...||| |||. || .. .|.. |.  . |.  |||. .|.. .||.| . ||| . .|.||||||||.||  .|.. . ||. .. ..    |
tkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PIVVHCSAGVGRTGTYIGIDAMLEGLEA---ENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF
|||||||||.|||||.| ||..|. .|    . ..|..  | ..|.||  .||.|.|| ....|. .| . 
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0036941 (Phosphotyrosine protein) phosphatases II 932-1228 2.6e-79 261.9 In-house 3-276 (297) alignment 
Range on Protein: 932-1228
Range on HMM: 3-276/297.0
MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelemskesehdsdE--SsdddsdseepSKYINASFIMSYWKP
.|. .... .. |. ||..|...  . .  ... .||..||| ....|||..|| |               .  .          | |||||..  |. .
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...............ddeg..........sdYinAsyvdgydlk

EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDTDK--SSTYTLRVFELRHSKRKDSRTVYQYQYTN
  .||.||||..|..|||.|... .|.||||||||   . | |||||    .. .||||. | |.....  ...||||..|. . . ..||||....||.
rkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytg

WSVEQLPAEPKELISMIQVVKQKLPQKnssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAE---TEEVVDIFQVVKALRKARPGMVSTFEQYQFL
|    .|  |..|...|. |...|..          ...| |.||..|   .| |.|.  .|.  |   .|. |||...|| ||. |||.| |.|||.||
wpdhgvpespaslldfielvrkvlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YDVIAST
|....  
yeallel
0047943 (Phosphotyrosine protein) phosphatases II 933-1226 2.7e-79 261.8 In-house 3-269 (273) alignment 
Range on Protein: 933-1226
Range on HMM: 3-269/273.0
KKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelemskesehdsdesS----DddsdseepskYINASFIMSYWK
....... .. |..||..|.|.  . |  ... .|||.|||.....|||..|| |                 .    |          |||||..  |..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.................gdggsd..........yinAsyvdgynl

PEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG----KQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTN
.  .||.||||..|..|||.|... .|.||||||||   ..| ||||| .     ..|||.. | |..... ..||.|..||.... ..||||....||.
krkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytg

WSVEQLPAEPKELISMIQVVKQKLPQKNSSegnkhhksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV
|   . |. ...|...|..|...| . .|.        .| ..||..|   || |.||. ||.  |.|  ||....|| ||. ||||| |.|||.|||..
wpdhgvppslesllefielvrkalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea

IA
..
ll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 651-987 5.9e-79 260.5 In-house 18-353 (515) alignment 
Range on Protein: 651-987
Range on HMM: 18-353/515.0
RLFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
 ||  ||. .|     .|   |..  | .|||| .||||| .|| |  || .  |.|.||||| .|.  . |||.||| . .||||||...... | |.|
tlfseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiam

VTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEkatGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIV
||. .||.. ||..||| .   .  || . |..   . | . |..||...  ..    | ||  .|| |||.|||..   |||| . | |  . .. |..
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR
.|||||||||| .| || ..   .  . |||. .| ..|..|  .|| . || .|..|. |.  . .| . .  .  .| ...        | .  ||| 
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqt

L----PSYRSWRTqHIGNQEENKSKNRNSNVIPYDYNRVPL
|    |   . .| . |   .|. ||| .| .| . ||| |
lkslcpdppasqt.rsgrtrdnhpknrygnnlplqrnrvil
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 631-921 2.6e-78 258.1 In-house 4-287 (315) alignment 
Range on Protein: 631-921
Range on HMM: 4-287/315.0
EPIHADILLETYKRKIADEGRLFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRD
.||  | |.    .| |     |  ...|||     .|.. |.|  |..||||..|..||  ||.|  .. | .|.|.||..|||.. .|.|||||||  
qpipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMeegTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKatgREVTHIQFTSWPDHGVPEDPHL
..|.||||...|.. . |||.|   ||...|. .|||        .| . |   . .   .| .. | .| ...    |||  ...||||| |||.    
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdni...revvqlhytswpdmgvpkytip

LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN
|..| |.|. . .   |.||||||||||||||.| .||.|. .|||| .||| .. ..|..|  |||| .|| .|..||.|    |.| . 
lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia
0046845 (Phosphotyrosine protein) phosphatases II 944-1226 3.5e-78 258.2 In-house 2-271 (284) alignment 
Range on Protein: 944-1226
Range on HMM: 2-271/284.0
LEAEFQRLPSYRSWR--TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELemskesehdS-----DessdddsdseepskYINASFIMSY-----WKPEV
||.||..|.|.  ..  . .... .||.|||| ....|||..|| ||..          .     |              |||||..  |     ...  
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksld.........gdledsd..............YinAsyvdgydldltyikkk

MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG--EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-RKDSRTVYQYQYTNWSVE
.||.||||..|..|||.|... .|.||||||||   ..| |||||   ....||||. | |..... ..||.|..||.. .  . ||||....||.|   
fIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdh

QLPAEPKELISMIQVVKQKLPQknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEE---VVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
. |..|. |..... |.. |..        .... | ..||..|   || |.||  |||  |.|.   .||....|| ||. ||||| |.|||.|.|...
gvppspedlleflrlvrellen........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeal

A
.
l
0040438 (Phosphotyrosine protein) phosphatases II 944-1229 4.1e-78 258.2 In-house 20-276 (317) alignment 
Range on Protein: 944-1229
Range on HMM: 20-276/317.0
LEAEFQRLPSYRSWrTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI
|. ||..|.|.  . |  ... .|||.|||.....|||..|| |..                    .. ..| |||||..  ....  .||.||||..|.
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsp...................lggdldsdYInAsyvdgpnlkrkfIatqgPlpntv

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
.|||.|... .|.||||||||.  ..| |||||  ....||||. | |..... . .|||..|. ... ..||||....||.|    .|  |..|.....
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

VVKQKLpqknssEgnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY
 |...|      |    ....|.|.|| .|   || |.|.. .||  |.|. ||....|| ||..|||.| |.|||.||||...  .
avreal......e....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 653-914 2.3e-76 251.5 In-house 7-269 (274) alignment 
Range on Protein: 653-914
Range on HMM: 7-269/274.0
FLAEFQSIPRVFskfPIKEARKPFNQNKNRYVDILPYDYNRVEL-SEINGDAGSNYINASYIDGFKEP-RKYIAAQGPRDETVDDFWRMIWEQKATVIVM
. .|| ..|  |   . .| . . .|.|||| .||| .  || | || . |  |.|||| || |..|  . |.|.|||  .||.||||||......||||
lekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTRCEEGNRNKCAEYWPSMEEG--TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEkatGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAF---SNFF
.|. .| |..|||.|.|  |.   .  .||| .|... ... || ..|| . . ..    |.|.|. .|.|||| .|.|.. ||.| . |.     .|  
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenak

SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
 .|.|||||||.|||| .|.|.  .  |..|..||| . |..|| .|  ||| . || |||.||..| .
lapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0043336 (Phosphotyrosine protein) phosphatases II 937-1226 3.1e-76 251.8 In-house 15-274 (278) alignment 
Range on Protein: 937-1226
Range on HMM: 15-274/278.0
PPSEPSPLEAEFQRLPSYRSwRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQ
 ..... |..||..|.|.    |. |.. .|||.||| ....|||..|| |..                    .....| |||||..  |..|. .||.|
llnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsl...................lggdldsdYinAsyvdgynvprkfiatq

GPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKE
|||.||..|||.|... .|..|||||||.  ... ||||| .| .||||. | |..... ..||.|..|. . . . ||||..|.|..|   ..|  .. 
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

LISMIQVVKQKLpqknssegNkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
|......|...|        .  ....|.|.||..|   || |.||. ||| .|.|  ||....|| ||. |||.| |..||.|||....
lldflkavreal........e..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 927-1226 6.9e-76 251.2 In-house 12-301 (307) alignment 
Range on Protein: 927-1226
Range on HMM: 12-301/307.0
PYLHNMKKRDPPSEPSPLEAEFQRLPSYRS--WRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELemskesehdsdeS-----SdddsdseepskYIN
 .|  ........ .. |..||..|.|.    . .  |.. .|||.||| ....|||..|| |...             .     .           |||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssld............gsledsd...........YiN

ASFI--------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG--KQTYGDIEVDLKDTDKSSTYTLRVFELRHS
||..         .|...  .||.||||.||. |||.|... .|.||||||||.  ..|.||||| .   ..|||.. | |..... . ||.|..|. ..
AsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl

-KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEV---VDIFQVVKALR
 . . ||||....||.|   ..|  ..||...|. |.. | .        . |..| |.||..|   || |.|.. .|.  |.|..   ||....|| ||
dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr

KARPGMVSTFEQYQFLYDVIA
. |||.| ..|||.|||....
eqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 928-1226 7e-76 250.8 In-house 18-286 (297) alignment 
Range on Protein: 928-1226
Range on HMM: 18-286/297.0
YLHNMKKRDPPSEPSPLEAEFQRLPSYRSWrtQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELemskesehdsdessdddsDSEEPSKYINASFIMSYW
.|. ........... |..||..|.|.  .  . |.. .|||.||| ....|||..|| ||.|                   .. ..| |||||..  |.
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkped..................gvdldsdYinAsyvdgyd

K-PEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQeICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHskRKDSRTVYQYQYTNWS
. .  .||.||||.||..|||.|... .|.||||||.|.  ..  ||||| |  .||||. | |..... . ||.|..|...   . ||||...|||.| 
lltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp

VEQLPAEPKELISMIQVVKQKLPQKnssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
  . |  .. |..... |.. | .         .|..| |.|| .|   || |.|.. .||  |.|  ||....|| ||..|||.| |..||.||||...
dhgvppslellleflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0037934 (Phosphotyrosine protein) phosphatases II 670-912 1.5e-75 249.2 In-house 3-241 (243) alignment 
Range on Protein: 670-912
Range on HMM: 3-241/243.0
KEARKPFNQNKNRYVDILPYDYNRVELseingdAGSNYINASYIDGFkePrKYIAAQGPRDETVDD----FWRMIWEQKATVIVMVTRCEEGNRNKCAEY
. |..| |..|||| ||||||..|| |       ||.||||..|...  | ..|| ||| .|||.|    ||||.||.. |||||.|...| .|.|||.|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsmeeG-TrAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAF--------SNFFSGPIVVHCSAG
||    | .  .||..|.. . . ..||.. .| ..|....   |.|.|.....|||||||..|  ||.. . |..|         .  .||..||||||
wp....gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTYIGIDAMLEGLeaenKVDVYGYVVKLRRQRCL-MVQVEAQYILIHQALVEY
||||||.| .. ||. |    .||.. .| .||.||.  .|| . ||. ...|| |.
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 651-949 2.2e-74 245.2 In-house 19-313 (315) alignment 
Range on Protein: 651-949
Range on HMM: 19-313/315.0
RLFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
 ||  ||. .|     .. . ||.. |..|||| .|||.| .|| |  |. .  |.||||||| .... . |||.||| . .|||||||....|.| |||
alfseefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

VTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLnIVNKKEkaTGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIV
||  .||.. ||. |||  .  .  || . |.. . . . | ...|| .. | |  . | ||  ||| |||.||...   |||| . | |  .    ...
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsll

VHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQ
|||||||||||  | || ... .. .. |||. .| .||..|  .|| | .| .|..|. |. .. .| . .  .  .|....     |  | .  ||.
vhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe
subfamily_PTPN3_pd Subfamily PTPN3 653-911 2e-72 238.4 In-house 17-273 (280) alignment 
Range on Protein: 653-911
Range on HMM: 17-273/280.0
FLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGdagsNYINASYI----DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI
 ||.|. . |   .  |..|||| | .|||| ||||||  ||.|.| .     .||||.|.    .. .   .|||.||| ..|. |||.|.||||...|
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMVTRCEEGNRNKCAEYWPSMEEgTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKaTGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGP
||.|   |  | || .|||..|. .  .|.  ||......   |....| . .|..|   |.....|...|||||||.|.. .|.. .||..  .  . |
vmlttlverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeeP

IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
.|||||||.|||| .| ..  |  .||...| .   | ..| ||  .|| ..|| .. .|...
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 677-915 4.8e-72 237.2 In-house 20-266 (270) alignment 
Range on Protein: 677-915
Range on HMM: 20-266/270.0
NQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFK-EPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG--T
... ||| ||||    || |.|.. |  ..|||| |. ||. |..|||||.|| . |. .|||||||.|.| |||.|  || .|.||. |||.  .   .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

RAFGDVVVKINQHKRCPDYIIQKLNIVnkkEKATGREVTHIQFTSWPDHGVPEDPH------LLLKLRRRVNAFSNFF--SGPIVVHCSAGVGRTGTYIG
 ..|.. |   ....   ||...|..    ||.. |...| ....|||||||...        |||. | | .... .  ..|..|||||||||||| | 
ledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF
.| ... || ..||||   . .||..|. .||   || ....|.||| ..
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 638-949 9.4e-72 236.9 In-house 10-324 (325) alignment 
Range on Protein: 638-949
Range on HMM: 10-324/325.0
LLETYKRKIADEGRLFLAEFQSIPRVFSkFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFW
|.|  ..| |..   |  ||. .| . .    | | || |..|||. .....| .|| |   . |. |.||||||.  .|.   ..||| |  .|..|.|
lvehvekkkaqdqdgfahefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlW

RMIWEQKATVIVMVTRCEEGnRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKeKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRR
|.. . ...|.|..   ..|  ..|| |||     .. || . ||.   .   ||. ..|.. . | |   | |   |. ||.| ||.. |  |. . . 
rlvldWrcsvvvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilql

VNAFSNFF------SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN
|.| |.        |.||.|||||||||||..| . ..|. .  | .||..|.| |||..|  ||.   |||||..||||.   |.|.| .| ..  | .
vkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklss

MKKRDPPSEPSPLEAEFQ
...|.| ..   .| ||.
lqernpltqklniekefe
subfamily_PTPRD_pd Subfamily PTPRD 1011-1243 1.9e-70 233.1 In-house 72-295 (564) alignment 
Range on Protein: 1011-1243
Range on HMM: 72-295/564.0
SEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG-KQTYGDIEVDLKDTDKSSTYTLRVFELRHS
 .| | ||||||| .| |..  ||.||||.||| |||.|........|||||.|.  ... |..|| |  ..|||...|.|... . ..|..| |.|...
gdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkk

KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPqknssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP
|...||.| |...|.|  .  | ....|...|. |..  .          ... |...||  |   ||.|...  .|| ...|..|||.|.|||||| |.
kssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRn

GMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQE
 || | |||.|....|.    ..| .|. .| ..
amVqteeQYiFiheailealacgntevesenlkq
0045098 (Phosphotyrosine protein) phosphatases II 940-1226 5.6e-70 231.2 In-house 5-269 (278) alignment 
Range on Protein: 940-1226
Range on HMM: 5-269/278.0
EPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPlkhelemskesehdsdessdddsdseepsKYINASFIMSYwkPEVMIAAQGPL
  ..|  ||..|..  .. .   .. ..|..||| ....|||..||                               |||||.|..|  |  .||.||||
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.............................dYINAsyidgy..pkkfIatqgPl

KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK-QTYGDIEVDLKDTDKSSTYTLRVFELRHS----KRKDSRTVYQYQYTNWSVEQLPAEP
..|. |||.|... ...||||||||.....| ||||| ||. .||||..| |....  ..||||......     .   ||.|....|..|     | .|
pstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslp

--KELISMIQVVKQKLP---QKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAetEEVVDIFQVVKALRKARPG-MVSTFEQYQFLYDVIA
  | ...... ... |    .. .|. . . ...| |.||. |   || ..|.  .||    |..||....|| ||. ||| .| ..|||.|||....
ilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 652-923 6.4e-70 230.6 In-house 27-294 (297) alignment 
Range on Protein: 652-923
Range on HMM: 27-294/297.0
LFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEprKYIAAQGPRDETVDDFWRMIWEQKATVIVMV
.|  ||. .|.    .|   |.|  | .|.|| .||||| .||.|  .| |  |.|.|||.. |.|.  ..|. | | ..||.|||.|........|||.
vfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

TRCEEGNRnKCAEYWPsmEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPE--DPHLLLKLRRRV-NAFSNFFSGP
.  .|... ||| ||.  ..|. .||||.|...  ...  .| ..|.. . | ||. | |   ||..|||. |..  . . ||||   | . ||.  .||
nddnerdk.kcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegP

IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLS
..|||.||||||| .. || ..   . |..||..|.| |||..|  .|| . || ....|..|.    .|... |
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 916-1231 1.1e-69 230.0 In-house 1-292 (298) alignment 
Range on Protein: 916-1231
Range on HMM: 1-292/298.0
GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRS---WRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHElemskesehDSDESSDddsdse
|.||.. ..|.  |..... ..  . . ...||||| |  |     ........|||.||| ...|..|. || |..|         |.|| ||      
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeke.........dadeesd......

epskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR
    ||||||. .| . .  ||.|.||.||. |||.|. ......|||||.|.  |.  . .|| . ||.|||.|.|.|. ... . .. | ... ..|.
....YiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkke

KDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQkLPQKNsseGNkhhksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM
...|.| | ..|.|. .. |.. . .. ... |..  .|..   ||     .|....| .| . .| |.|.  .|| ...|.|||.|||||.||| |||.
ekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqa...gn.....kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpga

VSTFEQYQFLYDVIASTYPA
| | ||| |.|...     .
vqteeqYvfiyeavlealds
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 653-925 1.9e-69 229.2 In-house 22-291 (439) alignment 
Range on Protein: 653-925
Range on HMM: 22-291/439.0
FLAEFQSIPRVFSKFPIK--EARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
|  .|..|  .  ..  .   | . ..| |||| |. ..|. || | || |   | |||| ||.|. ... |||.|||..||.|||||...|.|.. |||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

VTRCEEGNRnkcaeYWPSMEEgtRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT-GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAF-SNFFSGP
.|   |  .     |||| .|    .||..|....    |.|.|. ....|.....   | | ......|||. || .   .|.. | .|.   .   ||
ltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSEL
.||||||||||||| | .|  || | .|||||. | |  ||.||  |||  .||..|..|..|  ..|.. | . |.
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPN13_pd Subfamily PTPN13 656-911 2.7e-69 228.5 In-house 16-267 (273) alignment 
Range on Protein: 656-911
Range on HMM: 16-267/273.0
EFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGdagsnYINASYIDG--FKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR
||. .  . ..   ....|  |..|||| ..||||  ||.|..  |     |||||.|     |.  .|||.|||  |||.|||.|.|||||.||.||| 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

CEEGNRNKCAEYWPSMEEGTRAFGD-VVVKINQHKRCPDYIIQKLNIVNkKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNfFSGPIVVH
  |... ||  |||. .. .    . . |.  . ..  .. ...|.. . .| .  |||.|..|..|||||||  .  ||.. ..|. . .  .||||||
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvh

CSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
||||.||.||.| ||..|. .| ....||   | |||.||  .|| . |||....|..|
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0040439 (Phosphotyrosine protein) phosphatases II 961-1226 4.1e-69 228.2 In-house 4-243 (249) alignment 
Range on Protein: 961-1226
Range on HMM: 4-243/249.0
HIGNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVM
 ... .|||.|||.....|||..|| |..                    .. ..| |||||.|  |. .  .||.||||.||..|||.|... ...||||
svallpenkdknrypdilpydhsrvklsi...................lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivm

LTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKnssegnkh
||.|.  ..| |||||  .| ..|||. | |....... ||.|..|| ... ..||||...|||.|   ..|  ...|...|. |.. | .         
Ltslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........

HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
.|..|.|.|| .|   ||.|.|.. .||  |.|  ||....|| ||..|||.| ..|||.|||....
pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Ptp69D_pd Subfamily Ptp69D 944-1233 1.1e-67 223.4 In-house 24-290 (307) alignment 
Range on Protein: 944-1233
Range on HMM: 24-290/307.0
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHeLEMskesehdsdessDDDsdseepSKYINASFIMSYWKPEVMIAAQGPLKETI
|. |...|..  . .. ......||. |||  .....| .|| ||. ...            ..|      |.||||||| .| . .  ||||.|. .||
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkk.ing............ked......sdYinasfikgykekkkfiaaqdPveati

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----RKDSRTVYQYQYTNWSVEQLPAEPKEL
||||.|| . .|..||||..|.  ... ||.||  | .. |||| |.| ...| | |. | ... . |      .||| | ||.||.|   . |  .. |
gDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargl

ISMIQVVKQkLPQKNssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQN
. .|. |.. |...|          .|...||. |....||| ||  ||.  ..|. ||||..|| ||. |. .|  .|||.|||  .. .    .
lklieqvre.lykln.........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 649-917 2.1e-67 222.0 In-house 18-287 (290) alignment 
Range on Protein: 649-917
Range on HMM: 18-287/290.0
EGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGD--AGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT
  . | ..|...    |.. .. .  . |...||. .|..|| ||. | .|.|.     .||||.||.|.|| ..|||.|||  .|. |||..||..| |
gnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvt

VIVMVTRCEEGNRNKCAEYWPSMeeGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG-VPEDPHLLLKLRRRVNAFSNFF
.|||.|   | ...||  |||.   .|.|.| . .|... . . .||..||.. ||..... ..||. |.|.|...| |..    || ......      
iivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGE
 ..||||||..|||..... ..  ..  . |  .||.  . ..| |.  .|| . || .|.| ...| .  |
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPRA_pd Subfamily PTPRA 945-1231 2.1e-67 222.3 In-house 35-297 (330) alignment 
Range on Protein: 945-1231
Range on HMM: 35-297/330.0
EAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHelemsKesehDSDESSDddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIG
  ||. ||. .   |  . ..|||| |||  |..|||..|| | .     |    .  |.||          |||||||  | . .  ||||||..||. 
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsv.....k....eGveesd..........yinasfidGykekdkfiaaqGPkeetve

DFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELR----HSKRKDSRTVYQYQYTNWSVEQLPAEPKELIS
|||.||...|   ||||||||  ..| |||||  ||  |||.| | ..|.  .  ||.| | ..    ....|.|| | |. .| |    .|.||. ...
dfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlk

MIQVVKQKLPQknssegnkhhKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPA
... ||.. .|          .. |. .||  |  .|| |..| ..||  ..|..||.|..|| ||. || || | |||.|.| |.   |  
llkkvkklnqq..........sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 944-1240 3.5e-67 221.7 In-house 22-291 (318) alignment 
Range on Protein: 944-1240
Range on HMM: 22-291/318.0
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKheleMSkESEHDSDessdddsdseepskYINASFIMSYWKPEVMIAAQGPLKETI
|..|..||   ..  |..  ... || |||  |...||  || |.    |  |.|..||              ||||..|  | . .  ||||.|| |||
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLq....ml.egeegsD..............yinanyidGyrrkkayiaaqaPlpeti

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
 |||.|..... .||||||...   .. ...|| ..| ..||.. |.||.. ..|.|.|| |...... ..||.| ||.||.|. | .|... .|.....
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvr

VVKQKlpqknssegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN
 |..          ..... .|...||  |  .||.|.|.  ||| .. |..||.||.|| ||. |. || | .||.|.|||.     . . .|. ..
qvska.........qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasd
subfamily_PTPN14_pd Subfamily PTPN14 645-912 2.4e-66 218.7 In-house 18-295 (300) alignment 
Range on Protein: 645-912
Range on HMM: 18-295/300.0
KIADEGRLFlAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDaGSNYINASYIDGF--KEPRKYIAAQGPRDETVDDFWRMIWE
|. .||..| .|.. ||.   .  .. |. | |..|||. |.|||. ||||||  . .  ..||||| |      . |.||.|||| . || |||.|.||
kkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

QKATVIVMVTRCEEGNRNKCAEYWPSME--EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKeKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
|. ..|||.|. ||. ..|. .|.|..|  . |  ||   |  . ..  . .| ..|..         |.| |.|.| |||||||||..  |.  ..|..
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

-------FS--NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
        .  .  . |..|||||||||||  |  | ... || ....|.   . .||.|| |.||  |||  ....|..|
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
0042113 (Phosphotyrosine protein) phosphatases II 963-1226 3.3e-66 218.5 In-house 4-240 (245) alignment 
Range on Protein: 963-1226
Range on HMM: 4-240/245.0
GNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLT
.. .|||.|||.|...|||..|| |..                    .... | |||||..  |. .. .||.||||.||..|||.|... ....|||||
allpenkdknrysdilpydhtrvklsp...................dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLt

ELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQknssegnkhHK
|.   ... |||||  ....||||. | |..... ..||.|..|. . . . ||.|..|.|..|   . |  .. |..... |.. | .         ..
eeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........ds

STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
..|.|.||..|   || |.|.. .|| .|.|  |.....|| ||. |||.| |..||.|||....
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 676-921 5e-65 214.3 In-house 46-286 (287) alignment 
Range on Protein: 676-921
Range on HMM: 46-286/287.0
FNQNKNRYVDILPYDYNRVELSeingDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEgtRA
 |..|||. .||..| .|| |     .   .||||..|||.|| ...|.|..|  .|. .||..|.... |.|||... .| ....| .|||. .     
qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vv

FGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG-VPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE
.|.  ... ....  .||..||.. ||..... ..|.  |.|.|...| |.|    || . ... .      ..||||||..|||..... ..  ..  .
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN
 |  .||.  . . | |.  .||  .||. | ....|| . .|| ..
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 944-1240 1e-64 213.6 In-house 24-294 (305) alignment 
Range on Protein: 944-1240
Range on HMM: 24-294/305.0
LEAEFQRLPSYrsWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHElemskesehD--SdessddDSDseepskYINASFIMSYWKPEVMIAAQGPLKE
|||... |..     . ..|..|.||.|||.......| .|. |...         .         |||      |||||.. .| . .  |.||||||.
leaqykslyee..eesidvgkkeankaknrlkeitlldddriiltek.........esld......dsd......yinasyvdgykrkkkyivaqgPlkn

TIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT---YGDIEVDLKDTDKSSTYTLRVFELRH-SKRKDSRTVYQYQYTNWSVEQLPAEPKEL
|. |||..|.. ||..|||||.|. |... | ||| | |.    .|...| ||.. . | |. | ...   .. |.|||| ||| |.|  .  | ..  |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

ISMIQVVKQKlpqknssegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVK
.|.|. |...          |. | .|||.|| .|   ||.|.|.   || ...|||||.|.|.|.||. |..||.| .||.||.|...    . . .. 
lslikrvqkd.........qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsii

KNN
 .|
gsn
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 677-911 3e-64 211.5 In-house 3-237 (237) alignment 
Range on Protein: 677-911
Range on HMM: 3-237/237.0
NQNKNRYVDILPYDYNRVELSEINGDagSNYINASYIDGFK-EPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEgTRA
|. |||| .|  ||..|| |    ..  |.||||.|..||   |.|||||||| . . ||||.|.|..| .||||.|   |||. || .|||| ..  .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paa

FGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF--FSGPIVVHCSAGVGRTGTYIGIDAMLEGL
.| . | . ...   || .. | .... ..   | .   |||||||.|||.    ||..|...   |.    ||| ..|||||||||| .. |||||   
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
. .. ||.| ||  .  .|  ..|.. ||..|||...|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_CG7180_pd Subfamily CG7180 651-912 3.7e-64 211.2 In-house 13-289 (296) alignment 
Range on Protein: 651-912
Range on HMM: 13-289/296.0
RLFLAEFQSIPRVFSKFPI---KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV
| | .|.. . .. ... |   . . .  |..|||.|...||||||| |....|.. |.||||.|.|.|  ...||  ..|..||||.|||.......  
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

IVMVTRCEEGNRnKCAEYWPSMEegTRAFGDVVVKINQHKRCPDYIIQKLNIVNK---------KEKATGREVTHIQFTSWPD-HGVPEDPHLLLKLRRR
.|..|.  . .. .. .|||        .|...|.| ..|  ..  |... .. |         ..||  | |...|.| |.  . ||     |..||||
vvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VNAFSNFF-----SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
|. . .        ||.||..| |..|.| |..||| || .| |..|||...| .|||.|  .|.   .|  | . | |.
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 943-1228 7.3e-64 210.6 In-house 22-278 (288) alignment 
Range on Protein: 943-1228
Range on HMM: 22-278/288.0
PLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehDSDESS--DddsdseepskYINASFIMSYWKPEVMIAAQGPLK
 .. |.. |..  . .....|.. .|..|||  |..|||..|| ||           . .| .  |          |||||.| .. | .. ||.|||| 
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklk...........kleeeagaD..........YinasyidgekkkkkyiatqgPla

ETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQ--TYGDIEVDLKDTDKSSTYTLRVFELRhsKRKDSRTVYQYQYTNWSVEQLPAEPKELI
.|..|||......|.. |||||||  |... | .|| ....   ||...| |... .   ..|| ..|   |.|. ... ||||. |. .. |.  ..|.
dtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapll

SMIQVVKQKLPQKnssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAST
 ... ||.  ...          . |...|| .|  .||.| || .|..  |.|...|.. .|. ||| |. .| | .||.|.|.|..| 
ellrqvkvanqad..........tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRG_pd Subfamily PTPRG 959-1243 1.1e-63 210.3 In-house 38-301 (563) alignment 
Range on Protein: 959-1243
Range on HMM: 38-301/563.0
TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKEseHDsdessdddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVI
. .  ...||| |||..|...||  || |.   .. |.  .|                ||||..|. | | .  ||.|||||.|. |||.||....|..|
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkk..lD................YinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK---R---KDSRTVYQYQYTNWSVEQLPAEPkeLISMIQVVKQklpqk
||.|.|..  .. | .||  .. .||| ..| |..... ..|| | . ... |       .. ..|.||.||.|   . |  .  |  .| |.|.     
vmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs..lpvLifvkks.....

nssEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQE
   .  ....  |...||. |  .||....|  ||.  ..|..|..|...| .|  |. .| | |||.||.|.. ..  ... ...... .|
...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_PTPN1_pd Subfamily PTPN1 651-914 4.3e-61 201.2 In-house 6-272 (290) alignment 
Range on Protein: 651-914
Range on HMM: 6-272/290.0
RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGdagsNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
||. . .. | .  |.||..||..| |.|.||| |. |||. |..| . .     .||||| ..  .  |.|| .|||  .||| ||.|.||||.  .||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTRCEEGNRNKCAEYWPSMEE-GTRAFGDVVVKI--NQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSN--FF
. .. | ...|||.|||. ||  .  . |. .|.   ...|   |....|.. |.| . | ||..|  .|.||| |||| |  .||.  .|         
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK---VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
 || |.|||||.||.||.. .|..|  .|....   ||.   ...||..|  ..|   |  . ..|..|  .
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_PTPN23_pd Subfamily PTPN23 677-912 9.7e-61 200.1 In-house 43-279 (288) alignment 
Range on Protein: 677-912
Range on HMM: 43-279/288.0
NQNKNRYVDILPYDYNRVELSeingDAGSNYINASYIDGFKE-PRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA
. .|||. |||||| ||| |     .   .|||||.. .      ..||.|.|...|. |||.|..|||. ||||..  || ...|...|||. .. |  
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

FGDVVVKINQHKRCPDYIIQKLNIvNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA----FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE
|||. | ...... . .. ..|.. . ... . ..|.|.|.||||..|||. |. ||..   |..      .    |.||||||||||||..  . | ..
fgdlsvtlksvretethvervlkl.etldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

GLEAENKV-DVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
 ||..| . |.   | .||.||  ||| ..|.    .| .|.
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 676-920 9.9e-61 200.0 In-house 39-300 (301) alignment 
Range on Protein: 676-920
Range on HMM: 39-300/301.0
FNQNKNRYVDILPYDYNRVELSEING--DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGT
 |.. ||. .| .|| ||. |.. .    .  .|||||||||..| .|.|||||| ..|. ||||.||..| . |||||  .|| ..|| .|||. |. .
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

RAFGDVVVKINQHKRCPDYIIQKLNIV--------------NKKEKATGREVTHIQFTSWPDHGVPEDPHLLLK-LRRRVNAFSNFFSGPIVVHCSAGVG
  || . |......  ||..|..||..              ..|.. ....|. .| |.||..||  .|.  |. .   . .      ||.|||||..|.
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVs

RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEV
|.|.|. ..  ||   ||  |||.. .  .||..  .|.   ||. |.... .| |. .|. 
rsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
0037934 (Phosphotyrosine protein) phosphatases II 961-1226 1.1e-60 200.6 In-house 3-239 (243) alignment 
Range on Protein: 961-1226
Range on HMM: 3-239/243.0
HIGNQEENKSKNRNSNVIPYDYNRVPLkhelemskesehdsdessdddsdseEPSKYINASFIMSYwkPEvMIAAQGPLKETIGD----FWQMIFQRKVK
.|.. .||.|||| |...|||..|| |                         |.| ||||..|. .  |  .|| ||||.||. |    ||.|... ...
siallpenlsknrysdilpydhsrvkl.........................egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgit

VIVMLTELKHGDQEICAQYWGeGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-RKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSse
||||||||.  ..| |||||  |..||||..| |...   . ||.|...|.. .  . .|.|..|.|..|   . | .|. |..... |.. . . .|  
vivmltelvElgrekcaqywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieells..

GNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAeteEvVDIFQVVKALRKARPG-MVSTFEQYQFLYDVIA
 .. ... |.|.||. |   || ..|.. .|.     . ||....|| ||. ||| .| |..||.|||....
llaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRK_pd Subfamily PTPRK 963-1227 1.2e-60 200.0 In-house 38-275 (314) alignment 
Range on Protein: 963-1227
Range on HMM: 38-275/314.0
GNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdeSSDDDSDseepSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLT
 ...||..|||  ....||  || |.               . |.|..    |.||||..| || .|.  |..||||.||. |||..... .   |||||
akkdenreknrsgdilaydrsrvfli...............tidgdps....sdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlt

ELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS--KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQknssegnkhh
||..  .  | .|| |  ..||||.| | .|.  . .  |.| ....  . .. |.| |.|...|.  . | . . |..... ||.. ..          
elvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..........

KSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS
.  ....||  |. .||.|.|.  .|. .|.|.|||.|..||.||. .. || | |||.|.||||  
eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 962-1227 2.5e-60 198.8 In-house 3-240 (250) alignment 
Range on Protein: 962-1227
Range on HMM: 3-240/250.0
IGNQEENKSKNRNSNVIPYDYNRVPLKHElemskeseHdSDESSDddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVML
.... .|| ||| ...|..|  || |..|        . .|. ||          ||||||. .| . .  ||.||||..|| |||.|....|...||||
vakkpqnkeknryadiialdssrvvLeke........k.gdkesd..........yinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmL

TELKHGDQEiCAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKlpqknssegNKHH
|.||  ... . |||  |. ..|||. |.|..... . || |.. | . |..|.|.| |.....|     |.. .  . ... |...         ... 
tnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqas.........qqqa

KSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS
...|....|  |  ..| |.|.  .|| ...|.|||.|.|.|.||| ||..| . ||| |.| .|  
gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 966-1231 5e-60 197.9 In-house 45-280 (287) alignment 
Range on Protein: 966-1231
Range on HMM: 45-280/287.0
EENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdessdddsdsEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELK
..|| ||| ......| .||.||                       .|   ||||.|| .| .    |.|..|. .|. .||..| .|.|..||||...|
sqnkdknRltqilvpdnyrvllk.......................gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

HGDQEICAQYWGEGK-QTYGDIEVDLKDTDKSSTYTLRVFELRHSK-RKDSRTVYQYQYTNWSVEQLPAEPKELISMIQvvkQKLpqKNssegNKHHKST
  |.|.| ||| |.|  ..|. .. | . .... |. | .|.....  .| ..| |||.|||  .   .||.  . .|.   ..   |.    ....  |
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie...emy..kt....qrkrgnt

PLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPA
....|| |.  ....|||    .. ..|| |.|.|||.|  |  .||.| | |||.|..|..     .
sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 676-925 5.8e-60 197.6 In-house 32-278 (283) alignment 
Range on Protein: 676-925
Range on HMM: 32-278/283.0
FNQNKNRYVDILPYDYNRVELSEINGdagsNYINASYID---GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSmeEG
 |..|||. .|.|.| .||||   .     .||||..|      |. .|||.||.| |.|| |||.|....|.| |||.|.  |..| ||. |||.  .|
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rG

TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEG
.  .|.  | ...      .||..| . ..    .   ..| |.  | . |       |.|. . .    .   ||||||||.|.|||...|.. | .. 
sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkd

LEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSEL
. .|  |||.  |  .| ||  .||   || |.|.. .|    |.|..   .|
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_PTPRB_pd Subfamily PTPRB 920-1229 8.4e-60 197.3 In-house 7-285 (293) alignment 
Range on Protein: 920-1229
Range on HMM: 7-285/293.0
VNLSELHPYLHNMKKRdppsEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehD--S----Dessdddsdsee
..|.... ....||..    .   .  |...| .  . ..... ....|..||| .|..|||..|| |.           .  .    |           
iklekfeehvkkmkad....sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLa...........alkdesgsD...........

pskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG--KQTYGDIEVDLKDTDKSSTYTLRVFELRHskR
   ||||..|  |. |   ||.|||| ||. |||.|....|...|||||.|  . .. | .|| .    ..||||.|.|. ... . ...| .....  .
...YinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..e

KDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqknssegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM
|..|.| ||..| |.    | ..| |..... |....        .|.....|...||  |   ||.| || .||.. |.|..|||| .| .||. |  .
keerkvrqyhftsWpdhgvPektktlldfvrtvreai........ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnll

VSTFEQYQFLYDVIASTY
| | .|| |..... .  
vqtekqYifihqcvldll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 944-1242 1.3e-59 196.8 In-house 25-296 (319) alignment 
Range on Protein: 944-1242
Range on HMM: 25-296/319.0
LEAEFQRLPSYRSWRTQHiGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesEHdsdessDDdsdsEEPSKYINASFIMSYWKPEVMIAAQGPLKETI
|| ||. |    .  ...  ..||||.||| .|...||  || |.         |       |.     | |.||||||| .| . |  ||.|.||..||
lekefkllkeavndtfds.askeenkkknryqnilaydrtrvvls.........el......dg....vegsdyinasfidgyqerekfiatqaPlenti

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK-QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRK-DSRTVYQYQYTNWSVEQLPAEPKELISMI
 |||.|...... ..||||.|.   .  . .|| | . ..|| . |.|.. .. . |  | ..|.. . . ..|.| ..|||.|. .. | . . |. ..
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

QVVKqklpqkNSsegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNH
. ..      .|    ....| |. .|| .|.  || |..|   ||  . |.|.|.|..|. ||  |. ||.. |||.|.|...     | . ... .. 
krir......ks...rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdl

Q
.
r
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 945-1226 6.1e-59 194.3 In-house 23-280 (290) alignment 
Range on Protein: 945-1226
Range on HMM: 23-280/290.0
EAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHeleMskeSEHdsdessdDDSdseePSKYINASFIMSYWKPEVMIAAQGPLKETIG
...|..| |  |  | ..|. ..|| .|| .|...|| ||..|..   .   |.|        |     . .||||..|  | . .  ||.|||...|. 
rnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrp...i...sgh.......kDC....tneyinAcyikgykekkqyiatqgpvsntlv

DFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG-KQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR-KDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
|||..| |.|| .|||||. .  ... | ||| .   ..|| ... | .  . ..|. | .|.....  .....| ||| |||  .   ..|.  ...|.
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvie

VVKQKlpqknssegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
 . ..         ....  |....|| |.  ....|||. . .. ..|| |.|.|||.| .|  .||.| | .|||...... 
emykt.........qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_PTPRN_pd Subfamily PTPRN 671-911 1.7e-58 192.7 In-house 50-290 (297) alignment 
Range on Protein: 671-911
Range on HMM: 50-290/297.0
EARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGfKEPRK--YIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPs
 |... | .|||. ..|||| .||.|.| . .  |.||||| |   ..||.  |||.|||  .|| |||.|.||| ..|||..|| || . ..|..||| 
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp.

mEEGTRAFGDVVVK-INQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID
 .||.  ..   |. . .|  | ||... . . | . . | | ||   | |||..|||  .. ||..||.||      | |||||||.|.||||.|| ||
.deGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

AMLEGLEA-ENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
 .|. |    ...|.   . .|| ||  .|. ..|. .. .|..|
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 942-1227 1.7e-58 192.9 In-house 5-266 (274) alignment 
Range on Protein: 942-1227
Range on HMM: 5-266/274.0
SPLEAEFQRLPSYRSWRTQHIGNqeeNKSKNRNSNVIPYDYNRVPLKHELEMskesehdsdessdddsdsEEPSKYINASFIMSYW-KPEVMIAAQGPLK
  ||.||  ||.  . . ...     ...|||  ...| .  || |..|                     .| |.|||| .|  |  . .. .|.|||| 
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesesse..................dedssyinanyikGydeeskayvatqGPlp

ETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT-----YGDIEVDLKDTDKSSTYTLRVFELRHSKRkdSRTVYQYQYTNWSVEQLPAEPK
.|. |||.||.|..|.||||||.||  ... ||.|. . ...     |||.|.  ... .   |..| . |....|  .|.|. | ||.|  .. | ...
ntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddan

ELISMIQVVkqklpqkNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS
.|..... |       ..|. ....| .| ..||  |  .||.| | .. .   . |.|||....|  ||  | ||| | |||.... ... 
tlldlvlev.......eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 666-914 2.2e-58 192.3 In-house 27-278 (287) alignment 
Range on Protein: 666-914
Range on HMM: 27-278/287.0
KFPIKEARKPFNQNKNRYVDILPYDYNRVELSEiNGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEY
 .  |.| . .. .|||| |.||.| .|| ||. .|. ||.|||| |. ....  ..||||||   || ||||...|.........||  |  |.|| .|
tatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyky

WPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKkEKATGREVTHIQFTSWPDHGVPED----PHLLLKLRRRVNA-FSNFFSGPIVVHCSAGVGRT
||  |   |  |  || ... .. |.| .. | ...  |    | |  ... ||||....        . |. ......  .    ||.|||...|.||.
wPerevPmrvGGysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
|... . .... ||   .|||   |..|| .|  .||   |. |. .||| | .
GillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 672-911 2.6e-58 192.0 In-house 3-239 (239) alignment 
Range on Protein: 672-911
Range on HMM: 3-239/239.0
ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFK-EPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPsme
|.|  |. |||| .|. ||..|| | ... |  |.||||||.  .   |. |||.||    .  |||||.|...  ||||.|   || ..|| .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

EGTRAFGDVVVKINQHKRCPDYIIQKLnIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAML
. |  . .. | . . .   ||||. . ....  ..  | | . .|| |||.|||.    .| |||..   |   . | |.||||||||||... |||||
dstskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

EGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
   . .. ||.. ||  .| .|  |||   ||..|| |..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 672-911 2.7e-58 192.0 In-house 2-238 (239) alignment 
Range on Protein: 672-911
Range on HMM: 2-238/239.0
ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFK-EPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPsme
|.|  |. |||| .|. ||..|| | ... |  |.||||||.  .   |. |||.||    .  |||||.|...  ||||.|   || ..|| .|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

EGTRAFGDVVVKINQHKRCPDYIIQKLnIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAML
. |  . .. | . . .   ||||. . ....  ..  | | . .|| |||.|||.    .| |||..   |   . | |.||||||||||... |||||
dstskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

EGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
   . .. ||.. ||  .| .|  |||   ||..|| |..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 651-921 3.6e-58 191.8 In-house 20-244 (392) alignment 
Range on Protein: 651-921
Range on HMM: 20-244/392.0
RLFLAEFQSIPRVfSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVM
 ||  ||. .|     .| . |.|. |..|||| .||||| .|| |  |.  . |.|.|||||..|.  . |||.|||   ..||||||......| |.|
alffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

VTRCEEGNrnkcaeywpsmeegtrafgdvvvkinqhkrcpdyiiqklnivnkkEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIV
||. .||.                                                  | |.  .|| |||..||.    |||. . |.|    .. |..
vtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

VHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN
.||||||||||  | ||...   .    |||. .|...||.|  |||.. || .|. |..|   . .| . 
ihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlip
subfamily_PTPN6_pd Subfamily PTPN6 921-1228 1.2e-57 190.3 In-house 5-296 (306) alignment 
Range on Protein: 921-1228
Range on HMM: 5-296/306.0
NLSELHPYLHNMKKRDPPSEPSPLEAEFQRLP--SYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdessdddSDSEEPSKYI
. .|..   ....| .   | . .| ||..|     ..  ... |.. |||.|||  |..|.| .|| ||                    ..|   |.||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk....................epsvpgsdyi

NASFIMSYWKP--EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG--KQTYGDIEVDLKDTDKSSTYTLRVFELRH-SKRKD
||..|.. .|   .  ||.|| |..|. |||.|..| . .||||.|.     .| ||.|| .   |..||.|.|   . .. ..|.|| . . . .| |.
nanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkke

SRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSegnkhhKSTPLLIHCRDGSQQTGIFC---ALLNLLESAETEEVVDIFQVVKALRKARPG
.|.|.||....|  .  |..|. ...... |..|  . ...      .. |...|| .|   || |    .||.|.|.  ..  .|| ..|| .|. | |
erevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsg

MVSTFEQYQFLYDVIAST
.| | .||.|.| .|.  
lvqteqqykfvykaikky
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 946-1255 2e-57 189.8 In-house 27-313 (325) alignment 
Range on Protein: 946-1255
Range on HMM: 27-313/325.0
AEFQRLPSYRSwRTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelEMSKESEHdsdesSDddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGD
 ||. |||  .  ....  . |||.|||  ||...| .|| |    |  |.. .     ||          |||||.. .. | .|..||| || .||.|
hefgllpsddg.iakkvamkpenkaknrfknvvaldksrvvl....etkkddps.....sd..........yinasylrddkkkdvflaaqaPltatind

FWQMIFQRKVKVIVMLTELKHGDQeICAQYWGEG---KQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
.|..... .  |.|.| ||..|..  ||.|| .     .|.| .|| |.  .. | |  ||....  |. ..|.| |.|.  |     .  |  |||..|
lWrlvldWrcsvvvvlneldlgkd.rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq

VVKQKlpqKNSSEGNkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHq
.||.    ..    |  . |||.|.|| .|  .||.| .|  .|.   .|  ||||..|| ||| || || | .|| ..|. .. .| . | .|  ..  
lvkav...servtan.tkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf.

EDKIEFDNEVDKV
| |.   .| . .
eaklsslqernpl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 962-1232 2.4e-57 189.3 In-house 43-282 (315) alignment 
Range on Protein: 962-1232
Range on HMM: 43-282/315.0
IGNQEENKSKNRNSNVIPYDYNRVPLKheleMSkESEHDsdessdddsdseepSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVML
. .. ||| |||  |.|.||  || |     .  | . .              |.|.||.||  | |..  ||||||. ....|||...|. ..  ||||
vakkienkqknryiniiaydksrvqlp....ll.endph..............sdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml

TELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFelRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKlpQKNSSegnkhhk
|.| .|... . .|| . | .|| | | .|. .. . || | .      ... |.|.|..|| |   ..|.    |. .|. |||   ..||        
tnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsv.......

sTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQ
 .....||..|  .|| |..|  .|. ||.|...|...... .|. | .||.. |||||.||..  |. . 
.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 932-1226 1.2e-56 187.4 In-house 24-288 (319) alignment 
Range on Protein: 932-1226
Range on HMM: 24-288/319.0
MKKRDPPSEPSPLEAEFQRLPSYRS-WRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPE
 .|.|   . . ||.||.|..       .|   | ..|| |||  |....| |.| |..                    . || | ||||||.  | ...
snksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvkler...................liGeefsdyinasfvtGyqrkd

VMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTelkhgdQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRH-SKRKDSRTVYQYQYTNWSVE
  |||||||..|. |||.||.. ..  ||.||      .. |.|||  .......  .|...  .... |..| .|| . .| || | . |. .  |   
kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdv

QLPAEPKELISMIQVVKqKLPQKNssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
  |  | .|. ... |. .| .|.       .. .....||  |. .||.. .|  ||.  . |. ||....|. ||. |. .|  . ||.|.|  . 
Gvpdypsdlmrlvkkvr.hltske.......nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN12_pd Subfamily PTPN12 959-1234 2.1e-56 186.0 In-house 31-282 (290) alignment 
Range on Protein: 959-1234
Range on HMM: 31-282/290.0
TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSkesehdsdessdddsdseePSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVI
... |..|||. |||  ...|||..|| |... |                      | ||||.||    ..   ||||||| .|. |||.||.. .|...
steagekeenvkknrykDilPydksrvelskieeee...................gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveiv

VMLTELKHGDQEICAQYWGEG---KQTYGDIEVDLKDTDKSS-TYTLRVFELRHSkrKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPqknss
||. ..   ..  |..|| |    . ..|..||.|.. .. .  ...| ......  |.||.|||..||.|   . |. .|.|...|. |..        
vmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.....

egnkhHKSTPLLIHCRDGSQQTGIFCAL---LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG
     ....||..||  |  .||. .|.    .||..  ..| .|.|..|  ||| |. .| | |||...|  .|.   .. .
.....sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 959-1238 2.9e-55 182.5 In-house 42-293 (297) alignment 
Range on Protein: 959-1238
Range on HMM: 42-293/297.0
TQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemSKesehdsdeSSDDDSDseepskYINASFIMSYWKpeVMIAAQGPLKETIGDFWQMIFQRKVKVI
.|   ..  | .|.| .|..||| .|| |.     .          .| |||      |.||||. .. .   .|. | | |.|. |||.|... .|..|
pqtvaekkvnfeksRYkniLPydssRvkLa.....iv........nddpdsD......yvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvsti

VMLTELKHGDQeICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA--EPKELISMIQVVKQKLPQKNSse
|||......|.  ||.|| . | .|.||. | |. ... . .  | .|....| |  | | |||...| ... .   . . |. .|. |...  |...  
vmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae..

gnkhhkStPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKK
      . |||.||  |  .||....... .  |. |. ||||..|| ||. || .| | |||.|.| ..  .  ... ... 
......g.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
0051429 (Phosphotyrosine protein) phosphatases II 705-932 1.4e-54 180.9 In-house 4-243 (272) alignment 
Range on Protein: 705-932
Range on HMM: 4-243/272.0
SNYINASYIDGFKE---PRKYIAAQGPRDETVDDFWRMiWEQKATVIVMVTRCEEGNRNKCAEYWP----------SMEEGTRAFGDVVVKINQHKRCPD
|.||||....|.     |.......|| . |..||||. .|.. ..||.....|| .|.||  |||          .... |  .|...|.. . . ..|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPhlLLKLRRRVNAfsnffSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVD--------VYG
||. .| ....    ..|||.|...|.|||||||...  ||.| . ...     .||..||||||..||||.. .. .|.|...|  ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

YVVKLRRQRCLMVQVEAQYILIHQALVEYnQFGETEVNLSELHPYLHNM
.| .||.||  .|| |.||. ...||.|.   . ..|. . |. .|. .
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 946-1226 1.4e-54 180.6 In-house 2-252 (284) alignment 
Range on Protein: 946-1226
Range on HMM: 2-252/284.0
AEFQRLPSYRS-WRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHelemskesehdsdessdddSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG
.||.|..       .|   | ..|| |||  .....| |.| |..                    . || | |||||||  | ...  ||.||||..|. 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvkler...................liGeefsdyinasfitGyqrkdkyiatqGPldntla

DFWQMIFQRKVKVIVMLTelkhgdQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRH-SKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
|||.||.. ..  ||.||      .. |.|||  .......  .|...  ..|. |..| .|| . .| || |.. |. .  |     |  | .|. ...
dfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvk

VVKqKLPQKNssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
 |. .| .|.       .. .....||  |. .||.. .|  ||.  . |. ||....|. ||. |. .|  . ||.|.|  . 
kvr.hltske.......nhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 946-1229 2.3e-54 179.4 In-house 23-277 (315) alignment 
Range on Protein: 946-1229
Range on HMM: 23-277/315.0
AEFQRLPSYRSWRtQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelEMSkesehdsdessDDDS--DseepskYINASFIMSYWKPEVMIAAQGPLKETI
 ||. ||     | |... ...| .|||  |..|.| .|| |    |.            ||.   |      |||||.| |. . .  ||.||||| ..
eefhdlpdPdiyr.qrvaretinfkknryknilPldsarvkl....evi...........ddsPdsd......yinasyiksvdddkayiasqgPlkasv

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE---GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSkrKDSRTVYQYQYTNWSVEQLPAEPKELISM
 |||.|..| ||  |||.|....||.  |.||| .       .| |.|.| ...  .  . | . .|.|  ..|||| |.|.|.|  .  . .   |. .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllkl

IQVVKqklpqknSSegnKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY
|. ||       ..   ...|  .||.||  |  .||..... . .. .. ...||.|..|| ||. || .| | |.| |.||..    
ikevk.......ad...ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN23_pd Subfamily PTPN23 935-1226 3.1e-53 175.5 In-house 8-277 (288) alignment 
Range on Protein: 935-1226
Range on HMM: 8-277/288.0
RDPPSEPSPLEAEFQRLPSYRS--WRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdessdddsdsEEPSKYINASFIMSY--WKPE
|  ... . |...|. | ..     | . |   . . .|||. ...||| ||| |.                       ..   ||||||. .     |.
rkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.......................gskDDYinAsfvkdlspgcPd

vMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK---QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSV
 .||.|.||..|..|||.|....|..|||||.. .  ... ...|| | |   ...||..| ||.. ...|.  ||..|.. . .  ..|   |.|.|. 
.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

EQLPAEPKELISMIQVVKQKLPQKNSSEGNkhhkstPLLIHCRDGSQQTGIFCALLNLLESA-ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
  .|| |..|. ....|.... ...           ||..||  |.. ||.|. .   ..   . . ..|| |||. ||. |  ||.. ||..|.|... 
lGvPasPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 947-1227 3.2e-53 175.6 In-house 23-274 (515) alignment 
Range on Protein: 947-1227
Range on HMM: 23-274/515.0
EFQRLPSYRSWrTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelEMSKESEHdsdesSDddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGDF
||. ||    .  | . ..| | .|||  |..||| .|| |    |. ... |     ||          |.|||.| |.      ||.|||.| .. ||
efhdlpgpniy.pqtvaqeeinfkknryknilPydsvrvkl....evindnPh.....sd..........yfnasyipsfdndkayiasqgPnkasvddf

WQMIFQRKVKVIVMLTELKHGDQEICAQYWGE---GKQTYGDIEVDLKDTDKSSTYTLRVFELrhSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQV
|....| .|  |.|.|.||.||.  |..|| .       .| |.|.|  ..  .  . | ...   | .||||| |...|.|  .  | . . |. .|. 
WrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKqklpqknsSEGNKHHksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS
||        .. ..     ||.|||  |  .||..... . .  |.| ..||.|..|. .|. || .| | ||| |.|...  
vk........adhgqyt..hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
0041856 (Phosphotyrosine protein) phosphatases II 677-920 5e-53 174.7 In-house 1-178 (182) alignment 
Range on Protein: 677-920
Range on HMM: 1-178/182.0
NQNKNRYVDILPYDYNRvelseingdaGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTrceegnrnkCAEYWPSMEegtraf
|..||||.||||||..|          ...||||....|   ....||.||| ..|| ||.||..|.. |.||..|         .  |||. .      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdvvvkinqhkrcpdyiiqklnivnkkekatGREVTHIQFTSWPDHGVPEdPHLLLKLRRRVNAfsnfFSGPIVVHCSAGVGRTGTYIGIDAMLEGleae
                                |.........|||||||. .. ||.. ..|..     .||..||||||||||||..... |..     
...............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

nKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEV
 .|...  |  .|..|. ||. . ||.....|| |. ....|..
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 944-1226 5.6e-53 174.9 In-house 17-273 (281) alignment 
Range on Protein: 944-1226
Range on HMM: 17-273/281.0
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSkesehdsdessdddsdseePSKYINASFIMSYWKPEVMIAAQGPLKETI
.  |.. | .     | .  ...||. ||| ||.. ||  || .... | .                    . ||||.|. .| ...  ||.|||. ...
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk...................ntDYinanfvpgykgekeyiatqgPvPasl

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK--QTYGDIEVDLKDTDKSSTYTLRVFELrHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMI
 .||||....||..|||.|.  ....  | .|| ...   .|||. |  . . ...||  |.|.| . .  ..|.| | .||.|     ||..|||..  
vafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefr

QVVKQKLPQKNSsegnkhhksTPLLIHCRDGSQQTGIFCALLNLLESAETE-EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
. |..   .|.          .||.|||  |  .|| . ||  |....|.| | .|. .||. |||.|  || |  ||.|.| .. 
kevlkltekktk.........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 961-1225 5.7e-53 174.6 In-house 26-262 (283) alignment 
Range on Protein: 961-1225
Range on HMM: 26-262/283.0
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEmskesehdsdessdddsdseepsKYINASFIM---SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV
 |   .||| |||| ...|.| .|| || | .                       .||||.||.   || . .  |.||.||..|. |||.|.|..|.  
diasadenkrknrnqeivpadqwrvelksesr.......................dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS-KRKDSRTVYQYQYTNWsveqLPAEPKELISMIqvVKQKLPQKNsse
|||||.|. . .. |.|||  .| . ||.  | |..   | ... . . ||..   |..  .  ||. .|    |  ...  |  .  ||  . . .   
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinsl..vkfnkvisl...

gNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
  ...| .|...||  |  .|..|.|.   .. | || |||.|.||| .|. |...| | .||.......
.qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_CG7180_pd Subfamily CG7180 963-1228 9.2e-51 167.2 In-house 37-289 (296) alignment 
Range on Protein: 963-1228
Range on HMM: 37-289/296.0
GNQEENKSKNRNSNVIPYDYNRVPLKHeLemskesehdsdessdddsDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLT
| ..||. |||. .|.||||||| |.. |                  | || |.||||... |. |..  |  ..| |||...||......... .|.||
glrkenreknrdvkvvPyDynRvvLek.l..................dGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

ELKHGDQeICAQYWGEG-KQTYGDIEVDLKDTDKSSTYTLRVFELRHS----------KRKDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLpQ
.     .  . .|| .  |. ||.|.|..  ... .  . | | | .              . |.| ..|.| | . ...|   . || ... |..   .
ktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr.e

KNssegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAST
|.    ... .  |..... ||.  .|...|.   || .| || ||.|. || ||. ||..| . |.|...|||.   
kv....dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 944-1227 2.6e-50 165.8 In-house 17-291 (301) alignment 
Range on Protein: 944-1227
Range on HMM: 17-291/301.0
LEAEFQRLPSYRSwRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESehdsdessdddsdseepSKYINASFIMSYWKPEVMIAAQGPLKETI
.|.....| .... .. ..| .||||  ||. |. .|| ||. ||.. .... .                  .|||||.| .| . .  ||||||.|.|.
feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcq.................reyinasyidgysekkkfiaaqgpmkktl

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG---KQTYGDIEVDLKDTDKSS-----------------TYTLRVFELRHSKrkDSRTVYQYQYT
 |||..|.| |.  |||.|.|| | .. | ||| ..   ....| ..| |...                     .|. | |. ...|  .|..| |.| |
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvt

NWSVEQLPAEPKElisMIQVVKQKLPQKNSSEGnkhhksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYD
.|  . .  ||.    ..||. . . .... .|       |...|| |.  ..|..|..   || .  | |||.|||.||.|. .||.| | ||| ..||
dWpqdGvvreprt...vLqviddvihrqqkigg......gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd

VIAS
||  
vidm
subfamily_PTPN14_pd Subfamily PTPN14 946-1225 7.4e-50 164.6 In-house 27-292 (300) alignment 
Range on Protein: 946-1225
Range on HMM: 27-292/300.0
AEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVplkhELEMSKESEHDsdessdddsdseepskYINASFIMSYW--KPEVMIAAQGPLKETI
.|..|.|  |   . . .. .||..|||  .|.||. |||    ||  .||....                ||||| |      |    |.|||||. |.
teyeripkkredallstaklpenaeknrfkdvlPyednrv....elsptkenstg................yinassikvsvggkersyivaqgPleltv

GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG-----KQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELI
 |||||... .|..|||||| . . .| . .|. .      . ..|  .|  | ...|.... . ..|.|   |. |||.  |||.|. ...| ..|. .
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

SMIQVVKQkLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
| .. |.  . .| .|| . .... |.|.|| .|  .||.      |... |..|..|| .|.. ||. |  .|.|. ||.|.|.|.
syLeevqs.vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_PTPN9_pd Subfamily PTPN9 959-1225 1.3e-49 163.8 In-house 33-286 (297) alignment 
Range on Protein: 959-1225
Range on HMM: 33-286/297.0
TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHElemskesehdsdessdddsDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVI
| .  ..  | .||| ..|. ||  || |...                   | .| | ||||.|.  | ... .||.|||||.|. |||.|.....| ||
tflasklranleknrytdvlcydetrvvlakv...................dedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSE
|| | .    .  |.|||    |  . .||..|   ...... |. ||.|....| ..||.|  .|.. |     | . ..|. ....|..|  .  .. 
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

G---NKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
|   . | .  |...||  |  .|| |..|   |.  |....||....|| ||. |  .. | |||.| |  .
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 676-913 1.2e-48 160.7 In-house 40-277 (307) alignment 
Range on Protein: 676-913
Range on HMM: 40-277/307.0
FNQNKNRYVDILPYDYNRVELsEINGdAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA
 |..|||| |.   | .|. . ...| . |.|| | |.    .|.|.|.||||...|. .|| |. ..|   ..|. .. |  . || .|||  |  . .
antdknryqdvkcqdkgrivv.kfdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

FGDVV-----VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNffsgPIVVHCSAGVGRTGTYIGIDAML
||.        ..  .| .||  . ..  .. .     | ..|.|.. |||.|||.     . |   |.   |    |.||||||||||.|| ..|  . 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn....pvvvhcsaGvGrsGtivaislvq

EG-LEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
.  .. .|  |.   | .|| ||   .| ||||. .|. |.|| 
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 677-913 5.9e-48 158.0 In-house 52-283 (290) alignment 
Range on Protein: 677-913
Range on HMM: 52-283/290.0
NQ----NKNRYVDILPYDYNRVELSEinGDAGsNYINASYIDGFKEPrkYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG
..    .|||| |.   |  || |..  |  | .|. | |..| | .  .| .||.  .|| |.|||. ..|...|||.    |  . ||..|.|  |  
dkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAfsnfFSGPIVVHCSAGVGRTGTYIGIDAMLEG
. .||.. |   ...   . ||.|.  | .|..     . |..  ||||. |.     ||.. | .       |||.|||||||.|||||.. |.. |. 
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqi

LEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
|    ..|. . |  ||. |   |||. ||... ..|... 
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 674-915 1.7e-47 156.7 In-house 30-261 (267) alignment 
Range on Protein: 674-915
Range on HMM: 30-261/267.0
KPFNQNKNRYVDILPYDYNRVELSEINGDagsnYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKcaeYWPSMEEGT
   ||..||. | |||| .|| |.. . .    ||||||..|.|  ...|. |.| . |. ||. .| .|| .|||..|.  ..| ..   .||     .
aeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgqa

RAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAtgREVTHIQFTSWPdHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL
. . |..|. .  |   || |  |..  |.| |  ..||   .  |    . . |.|   .    .   .  . |.||.||.||||.||.. ||..|| .
kkyqdltvehslekeendyqiitlelkfknesa..hnvtlyyykkwn.intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF
  |. .|.. .. |.| ||  .|..  .|| ||. |.|| ..
ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
0036282 (Phosphotyrosine protein) phosphatases II 704-907 7.6e-47 154.5 In-house 1-164 (174) alignment 
Range on Protein: 704-907
Range on HMM: 1-164/174.0
GSNYINASYIDGFKEPRKYIAAQGPRDetvddFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSmeegtrafgdvvvkinqhkrcpdyiiqklnivnkK
||.|||||..|..  ....|| ||| .     ||.|..|.. |..||.....| .. ||  |||.                                  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

EKATGREVTHIQFTSWPDHGVPEDPHlLLKLRRRVNAFSNF-FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEaENKVDVYGYVVKLRRQRCLMVQVEAQY
 .   |.. ..... |||||||...  ||.. ..|. . .   .||..|||||||||||| .... || ||. |. ||.. .| .||.||. ||| . ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

ILIHQ
. ...
rflyy
0049772 (Phosphotyrosine protein) phosphatases II 660-921 9.7e-47 155.5 In-house 29-288 (314) alignment 
Range on Protein: 660-921
Range on HMM: 29-288/314.0
IPRVFSKFPIKEARKPFNQNKNRYVDILPYDyNRVELSEINGDaGSNYINASYIDGFkepRKYIAAQGPRDETVDDF----------WRMI--WEQKATV
 ..| ... |. |....|..|||| ||||.| ||| |.  ... ||.||||||.|||   .|.||.|||...||.||          |||.  ....  .
slsvlpeltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM---------------------VTRCEEGNRNKCAEYWPSMEegtrafgdvvvkinqhkrcpdyiiqklNIVNKKEKATGREVTHIQFtSWPDHGVPe
|||                      ... ...   .|.... ..                           .... .|. ... ......  .||...| 
ivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........................eelydpelferlgikylri.pvpDgsap.

DPHLLLKLRRRVNAFsnFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLeaenKVDVYGYVVKLRRQRC-----LMVQVEAQYILIHQALVEYNQFGETEVN
..  .... . ....     ||..|||.||.|||||.. .. ..  |    .|..   .  .|..|       ...   ||. |..|| || .| ... .
lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfye
subfamily_PTPRN_pd Subfamily PTPRN 937-1227 5.2e-46 151.7 In-house 24-290 (297) alignment 
Range on Protein: 937-1227
Range on HMM: 24-290/297.0
PPSEPSPLEAEFQRLPSYRSW-RTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHElemskesehdsdeSsdddsdSEEPSKYINASFIMSY-WKPEVMIA
  .... ||.|.. | .|..  .|......|.| .|||...|.||| .|| ||.|             .      |.| |.|||||.|.    .  . ||
hlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkee.............a......saeksdyinasaildhdprapayia

AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG-EGKQTYGDIEVDLKDTD-KSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA
.|||| .|. |||||.... | |||.||.|.. . . |..||  ||...|.  ||.|      .  | .| | |.  . ...||| |. .  |  |. ||
tqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPa

EPKELISMIQVVKQklpqknSSEGnkhhKSTPLLIHCRDGSQQTGIFCALLNLLES-AETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS
..| |. . . | .      |  |    .|.|...|| ||. .||.....  .|.  .     .||   .. ||  |||.| | .|..| . ..| 
saksllefrrkvnk......syrG....rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 967-1225 1.4e-45 150.3 In-house 2-235 (237) alignment 
Range on Protein: 967-1225
Range on HMM: 2-235/237.0
ENKSKNRNSNVIPYDYNRVPLKHELEMskesehdsdessdddsdseepSKYINASFIMSYW-KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELK
||| ||| .|.. ||..|| ||                          | ||||... ..   |   |||||||. .  |||||..| |  |||||| | 
enkiknrygnivaydhsrvvlkgagsg.....................sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgli

HGDQEICAQYWGEGKQ--TYGDIEVDLKDTDKSSTYTLRVFELR-HSKRKDSRTVYQYQYTNWSVEQLPAEPKELIsmiQVVKQKLpqknssEGNKH-HK
 |... | .|| . .|  .|| . | ||  .. | ||.| . |  . . |. | ..|||.| |    .| .   |.   .  |. .      . ..|  .
egnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaall...rfrknii......nrsphvse

STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
|.| .|||  |  .||||  .  .|  |. ..||||.. |... . || .. | .|| |....|
sgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPN3_pd Subfamily PTPN3 1013-1229 1.4e-45 150.4 In-house 63-275 (280) alignment 
Range on Protein: 1013-1229
Range on HMM: 63-275/280.0
EPSKYINASFIMSYWKP-EV---MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEG--KQTYGDIEVDLKDTDKSSTYTLRVFEL
... ||||...       ..    ||.||||..|  |||||....|...|||||.|    .  | ||| |   ...||...| .. .|....| || . |
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl

RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRK
.... |..|.. | ||..|. ...| .......... |...           . |..|...||  |  .||.. .|   |   |..| | . ..|. .| 
kdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrd

ARPGMVSTFEQYQFLYDVIASTY
 |  .| | .||.|. . |   |
qramlvqtasqykfvCeailkvy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 672-912 3.8e-45 148.7 In-house 32-268 (281) alignment 
Range on Protein: 672-912
Range on HMM: 32-268/281.0
ARKPFNQNKNRYVDILPYDYNRVELSE-INGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME
  .| |..||||..|   |  ||.|   .     ..|| | ||      | || .|||. ||  |||||||....| |||. .  | ||.|||||.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEkatGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSnffsGPIVVHCSAGVGRTGTYIGIDAML
     |  . |. ..       .  .||.  . |    | .||  .  |||  |||   ..||. |.. | |     | |.||||||||.|| . ..  |
hcclqfdklsvsyedstvnkslvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkirars....tppvihcsagvgrsgtlmaveial

EGLEAENKV-DVYGYVVKLRR-QRCLMVQVEAQYILIHQALVEY
. . .   . |.   | .||   |.  ||   ||.|| . |...
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 958-1226 1e-44 147.6 In-house 10-261 (270) alignment 
Range on Protein: 958-1226
Range on HMM: 10-261/270.0
RTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelemskesehdsdessdDDSDSEEPSKYINASFIM-SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVK
 .... ..  .|  ||  ...|    || |                   .. .... ..|||| ..     ...  |||.|||. |. .||.||...||.
sesdlpeaargkklnRyadiLPsPatRvrl...................eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvt

VIVMLTELKHGDQEICAQYWGEGKQT-----YGDIEVDLKDTDKSSTYTLRVFELRhsKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK
 |||.|.|.   .. |..|| . ...     .|.|.|    . |.. | |.  .|.  .. ..| .  ..|..|  .  | |. . .|  |..|     .
aivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravr

NSSegNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
.|.  ....|..|||.|| .|   ||.. ||   ..  |... ||. .....||| |. .|.. |||.||| ...
rse..keldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 671-833 9.4e-44 144.4 In-house 27-188 (297) alignment 
Range on Protein: 671-833
Range on HMM: 27-188/297.0
EARKPFNQNKNRYVDILPYDYNRVELSEinGDAGSNYINASYIDGFKEP--RKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS
 |...    |||| ||| .| .|| |    . ....|||| |.   .|.   ||| |||| ..||||||....||   |||||.. .|. |.||| ||||
sakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

MEEGTRAFGDVVVKINQHkRCPDY---IIQKLNIVNKkekATGREVTHIQFTSWPDHGVPEDPHLLLK
 ... .  |||||.   .    ..   |. .|... .   .  | |.|.|| |||||||| | . | .
vvqerlkagdvvveflss.tsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvr
0043147 (Phosphotyrosine protein) phosphatases II 702-907 1.3e-43 144.0 In-house 2-155 (172) alignment 
Range on Protein: 702-907
Range on HMM: 2-155/172.0
DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCeegnrnkcaeywpsmeegtrafgdvvvkinqhkrcpdyiiqklnivN
| ||.||||||.|.   |...|| ||| ..|..|||||..|.. |.||..|..                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................l

KKEKATGREVTHIQFTSWPDHGVPeDPHLLLKLRRRVNA-FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLegleaeNKVDVYGYVVKLRRQRCLMVQVEA
.  .   |.. ......||||||| .. |||.. . ..  . .  .||..|||||||||||| . .. ||       .....  |  .|..|. .|| . 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYILIHQ
||.....
qyrflyy
subfamily_ptpA1_pd Subfamily ptpA1 670-874 2.4e-42 140.1 In-house 40-257 (418) alignment 
Range on Protein: 670-874
Range on HMM: 40-257/418.0
KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFkEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSM
 |  | .| .|||| .||| .. ||.| .|.   ||.|||| ||||   |...|..|||  .|. |||||.||... .|||..|  |  | ||  |||  
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

---------EEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPH----LLLKLRRRVNAF--SNFFSGPIVVHCS
          .|   ||   |.. .  . |.  |   ||    |  | |..|. |.  |||| .|.  .    ||  .  | |    |.    ||.||||
iggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRTGTYIGIDAMLEGLE
||||||||.     |.. |.
agvgrtgtfctavimmkkld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 676-912 3e-42 139.3 In-house 54-288 (305) alignment 
Range on Protein: 676-912
Range on HMM: 54-288/305.0
FNQNKNRYVDILPYDYNRVELSEINgdaGSNYINASYIDGFKEPR-KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME-EGT
 .. |||| |.   | . | |.. .    |.|| | |.     |  ..|.|||| |.|.|.|| |. ..|   |||. .  |  . |||.|||    |  
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

RAF-GDVVVKINQH---KRCPDYIIQKLNIVNKKEKAtgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAfsnfFSGPIVVHCSAGVGRTGTYIGIDAM
    | || ..      .| ..  |  ||.    ..     | |.|.| ||| |||      |.|   .         |||||||||.||||| . |. .
elksgivvenvsgskpmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyi

LEGLeAENK-VD-VYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
|| . |||| .  .   |  || ||.  .| . ||. ||. ...|
leki.aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 967-1222 4.4e-42 138.9 In-house 7-234 (239) alignment 
Range on Protein: 967-1222
Range on HMM: 7-234/239.0
ENKSKNRNSNVIPYDYNRVPLKhelemsKEsehdsdeSSDDDSDseepskYINASFIMSYW-KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELK
 ||.||| .|.. ||..|| |.      |        | |  ||      |||||..  |   |.  ||.|| .. . ||||.|..| .  |||||| | 
vnkaknryanivtydhsrvvle......kl.......sndphsd......yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgli

HGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISmiqvVKQKLpQKNSSEGNKhhkstPL
 | .. | ||| .    | .. | |. |.  . | .| | . .  . . | ||||..| |  . .|     ..     ...|.  |.|  | .     | 
eghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg....lrrki.tkdslpgar.....pw

LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY
.|||  |  .|| |  .  .|  |. .. ||||. |||.|. || || | ||| |..
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 967-1222 4.6e-42 138.8 In-house 6-233 (239) alignment 
Range on Protein: 967-1222
Range on HMM: 6-233/239.0
ENKSKNRNSNVIPYDYNRVPLKhelemsKEsehdsdeSSDDDSDseepskYINASFIMSYW-KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELK
 ||.||| .|.. ||..|| |.      |        | |  ||      |||||..  |   |.  ||.|| .. . ||||.|..| .  |||||| | 
vnkaknryanivtydhsrvvle......kl.......sndphsd......yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgli

HGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISmiqvVKQKLpQKNSSEGNKhhkstPL
 | .. | ||| .    | .. | |. |.  . | .| | . .  . . | ||||..| |  . .|     ..     ...|.  |.|  | .     | 
eghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlg....lrrki.tkdslpgar.....pw

LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY
.|||  |  .|| |  .  .|  |. .. ||||. |||.|. || || | ||| |..
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0049260 (Phosphotyrosine protein) phosphatases II 712-907 5.8e-42 138.3 In-house 1-144 (152) alignment 
Range on Protein: 712-907
Range on HMM: 1-144/152.0
YIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWpsmeegtrafgdvvvkinqhkrcpdyiiqklnivnkkekatgrev
.|||.. |...||.||| ..|..|||||..|...|.|||.|...| .. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLegleaeNKVDVYGYVVKLRRQRCLMVQVEAQYILIHQ
 ..... |||||||... ||| | . .. .    .||..||||||||||||.. .. ||      ..|... .|  .|..|  .|. . |......
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 653-913 6.3e-42 138.4 In-house 24-287 (305) alignment 
Range on Protein: 653-913
Range on HMM: 24-287/305.0
FLAEFQSIPRvFSKF-PIKEARKPFNQNKNRYVDILPYDYNRVELseiNGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV
. |||... | |  |  .|  ..  ...|||| |.   | ||| |   .|    .|| | |.    .|...| .| | ..|  ||| | ...|   | |.
lraefvamkr.fndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TRCEEGNRNKCAEYWPSMEEGTRAFGD----VVVKINQHK-----RCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAfs
    |   .||.||..| .. .  | .    ..||..  .     .  .  ...  .| .   .. | |||  .  ||| |||     .|.|  .  .  
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp..

nfFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVY-GYVVKLRRQRCLMVQVEAQYILIHQALVEYN
    ||||||||||.||||. . .. .|. | | ....     ..|.| ||   .| .|||...|| ...| 
..skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 964-1231 1.1e-40 134.3 In-house 34-279 (287) alignment 
Range on Protein: 964-1231
Range on HMM: 34-279/287.0
NQEENKSKNRNSNVIPYDYNRVPLKHElemskeSEHDSDessdddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE
..  . .||| ..|.|.| .|| | .|      .|. ||              |||| .. || . |  ||||||.  |..|||........ .....| 
eelaavkknryadvlPiddtrvllsae......gelGsd..............yinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LKHGDQEICAQYWGEGKQT--Y-GDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGnkhh
     .  | .|| | ..     |   | |. . |.  |. | . | . . ...| | |... .|  . |.     || ..  |||..  . ....    
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase....

kSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPA
   ||..|.  |  ..||. |.| |..  |    ||. .||  ||. | ..| .  |...||. ... | .
.vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0046846 (Phosphotyrosine protein) phosphatases II 702-912 3.1e-40 133.1 In-house 9-172 (176) alignment 
Range on Protein: 702-912
Range on HMM: 9-172/176.0
DAGSNYINASYIDGFkeprKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRafgdvvvkinqhkrcpdyiiqklnivn
| ...||||..|.|     ..|| |||  .|. ||..|..|.. |..|..| . | .| ||. ||| .|.                              
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

kkekatgrevtHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNffSGPIVVHCSAGVGRTGTYIGIDAMLEgleaENKVDVYGYVVKLRRQRC-LMVQVEA
           ..... |||||||.. .||  |.   .| ..   ||..||||||.|||||.. .. .      |. ..|.  . ..|.||.  .|| ..
...........qylhlpwpDhgvpdlelllellefirealke..ggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpe

QYILIHQALVEY
||  ..... ..
Qyrflyefelll
subfamily_PTPN13_pd Subfamily PTPN13 1014-1225 2.6e-39 130.1 In-house 59-265 (273) alignment 
Range on Protein: 1014-1225
Range on HMM: 59-265/273.0
PSKYINASFIMSYWKPE--VMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQ----TYGDIEVDLKDTDKSSTYTLRVFELR
 . |||||.|      .  ..||.|||| ||. |||||....|..||.|.|  | ...  | .|| | |.     .. .||.| .. | .....| ....
eggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk

HSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQkLpqknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA
.|. ..|| | . ....|   . |....||. ... |.. |          .....|...||  |  ..|.. ..  .|.  | .. .|. ..|. ||. 
dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.l..........qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreq

RPGMVSTFEQYQFLYDVI
| |.| | .|| | | .|
rqgvvqtkdqyifvykai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 946-1225 6.1e-39 128.5 In-house 24-232 (392) alignment 
Range on Protein: 946-1225
Range on HMM: 24-232/392.0
AEFQRLPSYRSWrTQHIGNQEENKSKNRNSNVIPYDYNRVPLkhelEMSkesehdsDESSDDDsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGD
 ||. ||.   .  | ....| |. |||  |..||| .|| |    |.        |...|.|        |.|||.| |.   . .||.|||   .. |
eefhdlpgpdiy.pqtvaqkeinlkknryknilpydsarvkl....evi.......ddipdsd........ylnasyipsfdnekayiasqgpnaasldd

FWQMIFQRKVKVIVMLTELKHGDqeicaqywgegkqtygdievdlkdtdksstytlrvfelrhsKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK
||.|.|| .|  |.|.|.|| ||                                         | .| ||| |...|.|  ...|     |. .|. ||
fwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevk

QKLpqknsseGNKhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
 .        |.    . ||.|||  |  .||.  .. ...  |..  .||.|..|  .|. || || | ||| |.|  .
adf.......Gqy...thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0041856 (Phosphotyrosine protein) phosphatases II 968-1231 1e-38 128.1 In-house 1-173 (182) alignment 
Range on Protein: 968-1231
Range on HMM: 1-173/182.0
NKSKNRNSNVIPYDYNRvplkhelemskesehdsdessdddsdseePSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTelkhg
|..||| |...|||..|                             .. ||||.........  .||.||||..|. ||..|. ......||.||     
nldknrysdilpydhsr.............................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....

dqeiCAQYWGEGKqtygdievdlkdtdksstytlrvfelrhskrkdSRTVYQYQYTNWSVEQLPAePKELISMIQVVKQklpqknssegnkhhKSTPLLI
    . .|| |                                    |...||.|..|     |  . ||...|. |..              .. | |.
....eelywpell.................................erlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlV

HCRDGSQQTGIFCALLNLLESaeteEvVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPA
||. |   || ..|.  ...     . |.....|| .|..||||| | .||.||....   .  
HCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellll
0051429 (Phosphotyrosine protein) phosphatases II 1015-1226 1.4e-38 128.4 In-house 4-222 (272) alignment 
Range on Protein: 1015-1226
Range on HMM: 4-222/272.0
SKYINASFIMSYWK---PEVMIAAQGPLKETIGDFWQMiFQRKVKVIVMLTELKHGDQEICAQYWG-------------EGKQTYGDIEVDLKDTDKSST
| ||||...  |..   | . ....|||. |. |||..  . ..|.||.|...   ... | .||              .   .||.. | |  .   . 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTLRVFELRHS-KRKDSRTVYQYQYTNWSVEQLPAEPkeLISMIQVVKQklpqknssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD-
|.||...|..  . ...|.|....||.|     | |.  |....... .               . |.|.||. |   ||...||| ||.  . | .|| 
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllgvsletivdd

-------IFQVVKALRKARPGMVSTFEQYQFLYDVIA
       ....|. ||..|||.| | |||.|||....
Ylltnlyleeaveelraqrpgavqteeqylflyeall
0036282 (Phosphotyrosine protein) phosphatases II 1015-1223 7.3e-38 125.3 In-house 2-164 (174) alignment 
Range on Protein: 1015-1223
Range on HMM: 2-164/174.0
SKYINASFIMSYWKPEVMIAAQGPLKetigdFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEgkqtygdievdlkdtdksstytlrvfelrhSKRKDS
|.|||||..  .. ..  || ||||.     ||.|... .....|||.|.|. . . | .|| |                               .   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RTVYQYQYTNWSVEQLPAEPKeLISMIQVVKQKLpqknssegnKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAEtEEVVDIFQVVKALRKARPGMVST
|...||.|..|   . |  .. |..... |.. |         ..... |.|.||. |   ||...|.. .|   . | .||....|..||. ||||| |
rlgiqylylpwpDhgvpdlsi.llefvkfveeal.........sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

FEQYQFLYD
..||.|||.
psQyrflyy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 677-913 2.2e-36 120.4 In-house 43-271 (288) alignment 
Range on Protein: 677-913
Range on HMM: 43-271/288.0
NQNKNRYVDILPYDYNRVELSeingDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAF
|  ..|| ..   |. || ||    |    ||.|  .   | .|. | || | . |.. .|.|. |.    |||...  |  ..| |||.||    .  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVnafsNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAE
| .   . ...   | ...   . ..||  .   | .. .  |.|.||||.    |.|  ..    . .  |||||.||||||||| | |  .|| |  .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrld

NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYN
. . .   . ||| .|   .|.| ||. .|. . |. 
dflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 965-1226 2.2e-36 120.2 In-house 45-276 (439) alignment 
Range on Protein: 965-1226
Range on HMM: 45-276/439.0
QEENKSKNRNSNVIPYDYNRVPLKhelemskE---SEHdsdessdddsdseepSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVML
|| ...|||  .| ..|. || |.       |     |               |.|||| .|  |..... ||.||| |||  |||......|.  ||||
qeydqtknrykdvgafdhtrvtlq.......eipgvph...............shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

TELKHGDQeicaqYWGEGKQTY-GDIEVDLKDTDKSSTYTLRVFELRH--SKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVkqklpqkNSSegNK
|.| .  .     ||   .... ||| |      .   |..| | .     . .  ||| |..|. |  ...||.   .. ... .       ||.  | 
tnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai.......nsa..nd

HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
...  |...||  |  .||   ||   ||   .|. |||  .|| ||| |  || .. || |.|. . 
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPN1_pd Subfamily PTPN1 1014-1225 3.4e-36 119.4 In-house 55-267 (290) alignment 
Range on Protein: 1014-1225
Range on HMM: 55-267/290.0
PSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQ----TYG--DIEVDLKDTDKSSTYTLRVFELR
  .|||||..         | .|||| .|.. ||||....| | .||| ..   .|  ||||| .|..    ..    ..|.|  ....|.||.|..|| 
dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllele

HSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknSseGNKHHKSTPLLIHCRDGSQQTGIFCA---LLNLLESAETEEVVDIFQVVKAL
  | ...|..... || |.   .|  |  ...... |..      |  |   ..  | .|||  |  ..| ||    .| |.|  .  . ||| .|. .|
nlktqetreilhfhyttwpdfgvpespaaflkflfkvre......s..GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllel

RKARPGMVSTFEQYQFLYDVI
|| | |.. | .| .| |  |
rkyrlGliqtadqlrfsylai
0051082 (Phosphotyrosine protein) phosphatases II 705-909 9.5e-36 118.0 In-house 3-149 (151) alignment 
Range on Protein: 705-909
Range on HMM: 3-149/151.0
SNYINASYIDGFkeprkYIAAQGPRDetvdDFWRMIWEQKATVIVMVTRCEEGNrnKCAEYWPSMEegtrafgdvvvkinqhkrcpdyiiqklnivnkke
|.|||.||..|.     ... .|| .    ||.....|.. ..||...  || .  .|.||.|...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

katgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAfsnfF-SGPIVVHCSAGVGRTGTYIGIDAMLEGleaenkVDVYGYVVKLRRQRCLMVQVEAQYI
    .||.||....|||.|.|. .. .|.. . ...      .||..||||||.||||| .... ||.|      |...  .  .|..|. .|| . |..
....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

LIHQAL
....||
fqlfal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 678-921 1.8e-35 117.0 In-house 53-297 (310) alignment 
Range on Protein: 678-921
Range on HMM: 53-297/310.0
QNKNRYVDILPYDYNRVELsEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEeGTRAFG
  |||| |..  |  || | .|.     .|| | |.        .| .||| . |. ||||||....|  |... .  |  | ||  ||||.   | ..|
mhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vtetyg

DVVVKiNQHKRCPDYIIQKLNI---------VNKKEKATGREVTHIQFTSWPDHGVPEDPHLllKLRRRVNAfsNFFSGPIVVHCSAGVGRTGTYIGIDA
 . |  |  .   .. | .| .          ..  .  .  |. |..  ||| |||..      . .|. |  .   || |||||||..|... . .. 
cirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqrlla..qvrhgpcvvhcsagkdrlyvvvalkl

MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQfGETEVN
 .. |.  .|||.   . .|...|   .| | ||..|..  . . . ||||| 
kidkldrglkvdaeevktellksraiciqtelqyliidrvriifar.geteva
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 965-1228 9.8e-35 114.8 In-house 30-258 (267) alignment 
Range on Protein: 965-1228
Range on HMM: 30-258/267.0
QEENKSKNRNSNVIPYDYNRVPLKHELEMskesehdsdessdddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTEL
 |.|. .||  ...||| .||.|. . |                        |||||.. .| . . .|. |.||| ||.||...| ..|| |||.||  
aeknqernrlddnlpyddtrvilrtkeee.......................yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

khGDQEICAQYWGE--GKQTYGDIEVDLKDTDKSSTYTLRVFELRHsKRKDSRTVYQYQYTNWSVEQlpaEPKELI-SMIQVVkqklpQKNSS-EGNKhh
  . ..|   .  .    . | |. |.     .   | . ..||.  | . .. |  | | .| ..    . |  .  .. ..      ||   .||.  
..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnint...nnkpylkplfgil.....aknqlengnr..

kstPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAST
   ||...| ||  ..| |  .   || | ||.|.|||. .. .|. |.|.| | |.| ......|  
...PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0044763 (Phosphotyrosine protein) phosphatases II 688-915 1e-34 115.1 In-house 1-173 (178) alignment 
Range on Protein: 688-915
Range on HMM: 1-173/178.0
PYDYNRVELSEINGDAGSNYINASYIDGFkeprKYIAAQGPrdetvDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEgtrafgdvvvkinqhk
|.| .|| ||.. |  .| |||||.|...     |.....|      |......|.. |.||..|   |....|| .|||. ..                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

rcpdyiiqklnivnkkekatgrevTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGleaenKVDVYGYVVK
                         . ... .||||||. .  .|.. . .... .   ||..|||||||||.|| . .. |..      .....  .  
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRRQRClMVQVEAQYILIHQALVEYNQF
.|..|. .|. . |.  ...   .... 
vrerRp.ivpnpgqlrqLyefelrllke
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 677-918 1.1e-34 114.7 In-house 35-274 (285) alignment 
Range on Protein: 677-918
Range on HMM: 35-274/285.0
NQNKNRYVDILPYDYNRVELSEINgdagSNYINASYID-GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRA
| . ||| |.   .  || | . .     .|| ||..    |.   ||..|||  ||. |||.||...| . ..|.    ||  .||| |.|        
npdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

FGDVVVKINQHKR--CPDYIIQKLNIVNKKEKAT-GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFsNFFSGPIVVHCSAGVGRTGTYIGIDAMLEG
||   . . . |       |.. | ..| .. ..    . |.|   |||.  ||| . ...| . |.   |    ||.|||||||||| |..|||     
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyatir

LEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNqFGET
.  . ....   | ..|  |   ||   |.....  |.||   || 
imenpniemldivremramrfqavqshmqflflyvvlmeyf.igeg
CD45 Leukocyte receptor CD45 236-295 1.3e-34 104.4 Pfam-A 1-60 (61) alignment 
Range on Protein: 236-295
Range on HMM: 1-60/61.0
TVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTL
||||||.||||||||||||||.|.|.||.|||||..||.||.. .||.||||||||.|||
tVdylYeketklftaklnvnekvkCenndCtnnelknLkECeektvsvshnSCtapaktl
subfamily_CG42327_pd Subfamily CG42327 655-834 2.3e-34 113.5 In-house 9-186 (319) alignment 
Range on Protein: 655-834
Range on HMM: 9-186/319.0
AEFQSIPRVFSKFPikeARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKE-PRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR
 ||. .|.. ..     .  .  ..|.|.....|    || | .|  |  ..|..|||. |... |  ||||| . ...  ||||..|||.. ||| .| 
eefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

CEEGNRNKCAEYWPSME--EGTRAFGDVVVKINQHKRCPDYIIQKLnIVNKKEKATGREVTHIQFtSWPDHGVPEDPHLLLKL
  |   ..||||.|. |  ..|...||. | . . .    |.|  | .... .|   ||.||  .  |.. .|| ..  |. .
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl.llkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 669-903 2.5e-34 113.4 In-house 42-271 (301) alignment 
Range on Protein: 669-903
Range on HMM: 42-271/301.0
IKEARKPFNQNKNRYVDIlPYDYNRveLSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS
|.|.   ....|.||  . | . .     |.  |     | | .|.   .|...||.||| ..| .||| |.   .   |||...  | . .||.|| |.
itesyaylpkdkhryptv.PckPst..avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

MEEGTRAFGDVVVKINQHKRC-PDYIIQ-KLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNffsgPIVVHCSAGVGRTGTYIGI
  . .   |   .||....    . |.. .|....  .| . | ||| |...|.|.|||.    | .|   |    .    |||||||||.||. ..|| 
kisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigt

DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYI
. .   .||......   . .|| .|   || . |  
eylareveadptieltealkhlrehrwngvqtnsqly
0043147 (Phosphotyrosine protein) phosphatases II 1012-1222 5.8e-34 112.7 In-house 2-154 (172) alignment 
Range on Protein: 1012-1222
Range on HMM: 2-154/172.0
EEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELkhgdqeicaqywgegkqtygdievdlkdtdksstytlrvfelRHSKR
.|.|.|||||..  |..|   || |||| .|. |||.|. ......||.||||                                           . . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

KDSRTVYQYQYTNWSVEQLPaEPKELISMIQVVKQKLPQKNssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLesaeteEVVDIFQVVKALRKARPGM
. .|...||.|..|     |  .. |..... ....| ...         . | |.||. |   || ..|.. .|      . ......|. .|..|||.
llerlgiqylylpwpDhgvp.llellleflefidellalsp.........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

VSTFEQYQFLY
| ...||.|||
vqnpsqyrfly
PTPc_DSPc_SM00012 811-910 1.2e-32 107.5 In-house 2-104 (105) alignment 
Range on Protein: 811-910
Range on HMM: 2-104/105.0
VTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPIVVHCSAGVGRTGTYIGIDAMLEGLEAE-NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQ
|.|...|.||||||||... .|.| | |. . |  .  .|.|||||||||||||.. .| .|. ||.| ..||.. .| .||.||  ||| |.||. ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALV
|| 
all
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 679-912 3.7e-32 106.3 In-house 45-275 (312) alignment 
Range on Protein: 679-912
Range on HMM: 45-275/312.0
NKNRYVDILPYDYNRVELSeinGDAgSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSM-----EEGT
. ||| .|  .|  |  |.   ||    || | ..     | .....||| ..|.  ||..     .| |....   |   .|||.|   .      |  
dlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

RAFGDVVVKINQHKRCPDYIIQKLNIVNKkeKATGRE--VTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFsnffSGPIVVHCSAGVGRTGTYIGIDAMLE
| . . . .|.   .  | | ...  |    ||||.|  . | |..||||||.|.     |.|   |.        |.. ||||||||||| . |..|. 
rvyteycteieiggkskdkithrvlkvvv..katgqesklnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlaliesmia

GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
 |    | .|    | ||..|.  |.| .||.   ....|.
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
PTPc_DSPc_SM00012 1116-1226 1.4e-30 100.9 In-house 1-104 (105) alignment 
Range on Protein: 1116-1226
Range on HMM: 1-104/105.0
TVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSsegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLESAETE-EVVDIFQVVKALRKARPGMVST
||..|.||.|. ...| |......... ||..  ...|        |.|...||..| ..||.|.||  ||.. |.| . |||||.||.||| |||||.|
tvkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt

FEQYQFLYDVIA
.|||.|||....
eeqylflyrall
0049772 (Phosphotyrosine protein) phosphatases II 960-1226 5e-30 100.7 In-house 38-277 (314) alignment 
Range on Protein: 960-1226
Range on HMM: 38-277/314.0
QHIGNQEENKSKNRNSNVIPYDyNRVPLkHELEMskesehdsdessdddsdseEPSKYINASFIMSYwkpEVMIAAQGPLKETIGDF----------WQM
  ......|..|||. ...|.| ||| | . |..                   . | |||||.. ..      ||.||||..|. ||          |.|
ilvadlflnrdknryldilpad.nrvil.pglpv...................sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

IF--QRKVKVIVM---------------------LTELKHGDQEICAQYWGEGKqtygdievdlkdtdksstytlrvfELRHSKRKDSRTVYQYQYTNWS
..  ...| .|||                     |..|  .  | .|... . |                        |  ... . .|....| .....
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk........................eelydpelferlgikylripvp

VEQLPaEPKELISMIQVVKQKlpQknssegnkhhKSTPLLIHCRDGSQQTGIFCALLNLLESAEteevVDIFQVVKALRKARP-----GMVSTFEQYQFL
 .. |  .. . ........   .          | .|.|.||..|   || |...  |.        |.. .... .|..||     |.. ..|||.| 
Dgsap.lledfdeflefieea..d..........kggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefi

YDVIA
.... 
leall
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 717-907 2.6e-29 96.8 In-house 2-198 (199) alignment 
Range on Protein: 717-907
Range on HMM: 2-198/199.0
KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK-EKATGREVTHIQ
|  |.|||.| |  ||. |||.|.||  .  ||||   .  .    . |||. | ||  .| . |  .     ||| |  | ..|.     . ||..| |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDHGVPEDPHL---LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAE--NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQ
|||| ..  |.   .   ..  |   . . .    |..|||| | | || .. .|  .   |      ||..    .||. || ..    .| .|.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_egg_pd Subfamily egg 666-910 3e-29 96.7 In-house 29-267 (307) alignment 
Range on Protein: 666-910
Range on HMM: 29-267/307.0
KFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGnrNKCAEY
. ....| .  |..| |   .   |. ||.|   .|    ..| | ...|     ..| || |  .||||||||.....   |||.|   |   ..|  |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPSMEEGTRAF--GDVVVKINQH--KRCPDYIIQKLNIVNKKekatgREVTHIQFTSWpDHGVPEDPHLLLKLRRRVNAFsnffSGPIVVHCSAGVGRTG
||  |. .  .  | . ..  .   |  | . . ||..|  .     .|  ...   . |     | .  |.. |..       | |.||..  || ...
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.....deerflehwqg.dvnnssdvysplrvlrklrnl....skpvvvqdilGvskaa

TYIGIDAMLEGLE--AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALV
| . |.  |  |      |  |   || ||..| | |.   .|..... ..
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 719-907 3.4e-29 96.4 In-house 3-197 (198) alignment 
Range on Protein: 719-907
Range on HMM: 3-197/198.0
PRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK-EKATGREVTHIQFT
 |.|||.| |  ||. |||.|.||  .  ||||   .  .    . |||. | ||  .| . |  .     ||| |  | ..|.     . ||..| |||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEDPHL---LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAE--NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQ
|| ..  |.   .   ..  |   . . .    |..|||| | | || .. .|  .   |      ||..    .||. || ..    .| .|.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0046846 (Phosphotyrosine protein) phosphatases II 1012-1225 4.2e-29 96.9 In-house 9-169 (176) alignment 
Range on Protein: 1012-1225
Range on HMM: 9-169/176.0
EEPSKYINASFIMSYWkpevMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGdievdlkdtdksstytlrvfelrhskr
.... ||||..|....     || |||| .|. ||..|... .....|.|||... ..  |..|| | ..                              
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

kdsrtvyQYQYTNWSVEQLPAEpKELISMIQVVKQKLPQKnssegnkhhksTPLLIHCRDGSQQTGIFCALLnLLESaetEEVVDIFQVVKALRKARP-G
       ||....|   . |   . |..... ... | ..            | |.||. |   || ..|.. |||.   |  ........ .|. || |
.......qylhlpwpDhgvpdl.elllellefirealkeg...........gpvlVHCsaGigRtgtlvaay.llel...ekglsveealalvreqRplg

MVSTFEQYQFLYDVI
.| |.|||.|||...
avqtpeQyrflyefe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1015-1225 1.1e-28 95.0 In-house 59-291 (297) alignment 
Range on Protein: 1015-1225
Range on HMM: 59-291/297.0
SKYINASFIMSYWKP--EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE---GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS
. |||| ...   ..     | |||||..|. |||...... |.||||...|. . .. || || .   .... ||. |.   .      .. . ||.  
rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqli

KRKDSRTVYQYQYTNWSVEQLPAEPKELISM--------------IQVVK---QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE
 |..|| |   |. .|    .|.. ..|  .              . .|.     .  .  |   .. ....||.||  |  ..|.      .|.    .
yrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk

EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI
 . |.  ... ||. |. .| |.||...|||..
ripdvaailsilreqrarlvqtleqfellydav
0051082 (Phosphotyrosine protein) phosphatases II 1015-1224 1.6e-28 94.6 In-house 3-148 (151) alignment 
Range on Protein: 1015-1224
Range on HMM: 3-148/151.0
SKYINASFIMSYwkpevMIAAQGPLKetigDFWQMIFQRKVKVIVMLTELKHGDqeICAQYWGE-Gkqtygdievdlkdtdksstytlrvfelrhskrkd
|.|||.|.. ..     ... .|||     ||.... . ..|.||.|..... .   |..|. | |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknssegnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESaeteevVDIFQVVKALRKARPGMVS
 ..|.......|.. .||  ........... .             .|. |.|.||. |   ||...||. .|.       |....... .|. |||.| 
.ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

TFEQYQFLYDV
...|..|.. .
pnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 1023-1223 1.9e-28 94.5 In-house 2-144 (152) alignment 
Range on Protein: 1023-1223
Range on HMM: 2-144/152.0
IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWgegkqtygdievdlkdtdksstytlrvfelrhskrkdsrtvyQYQY
|  |..|  .||.|||. .|. |||.|. . ....|||||||   . . |.||.                                          ||..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylh

TNWSVEQLPAEPKELISMIQVVKQKlpqK----NssegnkhhkstPLLIHCRDGSQQTGIFCALLNLLesaeteEVVDIFQVVKALRKARPGMVSTFEQY
..|     |  .  |. .......    .    .           | |.||. |   || ..|.. .|        |.....|. .|..|||.| ...|.
lpwpDhgvpdlsqlllflllfiekl...aldkgg...........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgql

QFLYD
.|||.
rflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1032-1224 9.5e-26 85.2 In-house 7-199 (199) alignment 
Range on Protein: 1032-1224
Range on HMM: 7-199/199.0
MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS--KRKDSRTVYQYQYTNWS
.||.| ||.||. |||||...     |||. . ..  .   . ||     |   || . |  |     . ||. .. |  .      .| . .||.| | 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

VEQLPAepKELISMIQVVkqklpQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE--EVVDIFQVVKALRKARPGMVSTFEQYQFLYDV
    |     |.  . |       .. |   .  | .|...|| ||   ||.| ||   . | |     |||.|.| | ||.|| |..|....|.|.|.|
ekttpn..valfvgfvva.....srevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1032-1224 9.5e-26 85.2 In-house 6-198 (198) alignment 
Range on Protein: 1032-1224
Range on HMM: 6-198/198.0
MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS--KRKDSRTVYQYQYTNWS
.||.| ||.||. |||||...     |||. . ..  .   . ||     |   || . |  |     . ||. .. |  .      .| . .||.| | 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

VEQLPAepKELISMIQVVkqklpQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE--EVVDIFQVVKALRKARPGMVSTFEQYQFLYDV
    |     |.  . |       .. |   .  | .|...|| ||   ||.| ||   . | |     |||.|.| | ||.|| |..|....|.|.|.|
ekttpn..valfvgfvva.....srevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 715-905 2.9e-25 83.4 In-house 85-280 (302) alignment 
Range on Protein: 715-905
Range on HMM: 85-280/302.0
GFKEPRKYI-AAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKI-------NQHKRCPDYIIQKLNIVNKKEK-
| .. .|       |. .|.. .| .| . . ...| ..   |.. .|||||.    .|.  ||   ||        ..     .. . ...| |.| | 
Gtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk

ATGREVTHIQFTSWPDHGVPEDPHLLLKLRRrvnaFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI
.. . |  ..|..||||| |....  |.. .    | . .   ..|||||||||||| . |   ..    ..  |.   |. .|. |   || | | | .
kvkktvdilafsawpdhGapkeaytaldilk....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_CG42327_pd Subfamily CG42327 1010-1148 3.8e-25 83.2 In-house 51-194 (319) alignment 
Range on Protein: 1010-1148
Range on HMM: 51-194/319.0
DSEEPSKYINASFIMSYWK-PEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-----GEGKQTYGDIEVDLKDTDKSSTYTLRV
 ... ..|..||..  | . |   |||| .|...  |||....... .||| ||.|     . ||.|.     ......|||| | ||. .    | .  
gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaist

FELRHSKRKDSRTVYQYQYtNWSVEQLPAEPKELISMIQVVKQKL
. |.. ... || .  | | .|   ..|||.. ||.|.  |.. |
lllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 967-1098 9.6e-25 82.0 In-house 46-170 (350) alignment 
Range on Protein: 967-1098
Range on HMM: 46-170/350.0
ENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHdSDESSDddsdseepskYINASFIMSY-----WKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVM
|  .||| .|..||. .|| ||. |. |.  .| | ...|          ||||...         .|.   ||.|.||..|. ||...|.. |||||..
elfaknrYknilPYehsrvkLkkslkssdakkh.slstnD..........YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

LTELKHGDQEICAQYWGEGkqTYGDIEVDLKDTDKSST
||..   . | | .|| ||  .| || | |... .. .
ltsdvelnlekcyrYWqeg..sydditvklaskwenim
0048076 (Phosphotyrosine protein) phosphatases II 765-912 2.1e-24 81.3 In-house 2-142 (145) alignment 
Range on Protein: 765-912
Range on HMM: 2-142/145.0
YWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFfSGPIVVHCSAGVGRTGTYI
||||.  .   .|.. . ..    .   |   ||. . .|  . |.........|||||||... |||.. . .... .   ||..||||||||||||..
ywpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlv

GIDAMLEgleaeNKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
... ||.     ..|...  . ..|.||  .|. . |.. ..... |.
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1024-1226 7.1e-24 78.9 In-house 230-435 (440) alignment 
Range on Protein: 1024-1226
Range on HMM: 230-435/440.0
MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKhgdQEICAQYWGEG--KQTYGDIEVDLKDTDKSSTYTLRVFELRHSKrkDSRTVYQYQ
  | | . .||.| ||  |. |||... . ..  |.|| .|.   .  |. ||       |.| . |  | ...     .| .||.. .  .   . |..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln...dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

YTNWSV----EQLPAEPKELISMIQVVK--QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTF
   |      . . .. . . ...|..   .|   . |.|  .     |.|.||  | ...|.||...| ||  . .  .|.|| .. || .|| .| |.
vqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

EQYQFLYDVIA
 .| . | ...
tdyllcykllt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 679-770 8.1e-24 79.0 In-house 49-154 (350) alignment 
Range on Protein: 679-770
Range on HMM: 49-154/350.0
NKNRYVDILPYDYNRVELS-------EI-NGDAGSNYINASYIDGF-----KEPR-KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAE
 ||||..||||. .||.|         .     ...||||.|.         .|  ||||.|.|  .|||||...| . | .||...|   | |..|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSME
||.  .
YWqegs
0048179 (Phosphotyrosine protein) phosphatases II 806-907 4.2e-23 77.1 In-house 44-139 (144) alignment 
Range on Protein: 806-907
Range on HMM: 44-139/144.0
ATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNfFSGPIVVHCSAGVGRTGTYIGIDAMLegleaENKVDVYGYVVKLRRQRCLMVQVEAQYILI
  .||........|||||||....|||.. . .... .  .||..||||||||||||.. .. |.     .......  .  .|..|. .|. . |.. .
fleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

HQ
..
le
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 692-906 5.2e-22 73.3 In-house 33-252 (290) alignment 
Range on Protein: 692-906
Range on HMM: 33-252/290.0
NRVELSEINGDAGSNYINASYIDgFKEPRKYIAAQGPRDE-------TVDDFWRMIWEQKATVIVMVTRCEEGNRN----KCAEYWPSMEEGTRAFGDVV
.|| | .      ..|| |...  . .  . |. | |. .       |. .|| |. . |.. .||.   || ..|     ||.| |  ...   |... 
trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VKINQHKRCPDYIIQKLNIVNKKEKatGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFsnffSGPIVVHCSAGVGRTGTYIGIDAMLEGLE-AENKV
||  .     | .. .| .   .|.     ||| .. .| .  |.||. .||.| . |.|       |..|||  |. |  .   |.     .   ...|
vkCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

DVYGYVVKLRRQRCLMVQVEAQYILIH
 .   . .||.|| |... . ..  . 
kledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 726-869 6.7e-22 72.8 In-house 39-171 (255) alignment 
Range on Protein: 726-869
Range on HMM: 39-171/255.0
QgprdeTVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQhkRCPDYIIQKLNIVNKKE-KATGREVTHIQFTSWPDHGV
      ||| |...|  .|..|.||..  .| ...|| .|.|   .. . . || |   .     | ... |.|. .   |   ..|.| ... |...  
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PEDPHLLLKLRRRVNAfsnffSGPIVVHCSAGVGRTGTYIGIDAM
||... .|.. . |       | ..|||||.|.||. ... .. .
Pelareilnilkvvrd.....sksvvvhCstGiGrsaafvlaelv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 946-1225 1.5e-21 71.3 In-house 15-265 (281) alignment 
Range on Protein: 946-1225
Range on HMM: 15-265/281.0
AEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELemSKEsehdsdESSDddsdseepskYINASFIMSYWKPEVMIAAQGPLKETIGD
 ||  ||         . ||  |. ||| .|.   |  || || ..   ..      .|.|          || | .| | .     | .||| |||  |
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkm..pnk......nstd..........yihanyirspflkrgyiltqgpkketrad

FWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT---YGDIEVDLKdtDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKeliSMIQ
||.||.| .   |||| ..   ..| ||.|.    .    .  . |. .  | .   .|    |  |   ..| . .. . .|   |.|   .    |..
fwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsye..dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpesse...vmlk

VVKqKLpqknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE-EVVDIFQVVKALRK-ARPGMVSTFEQYQFLYDVI
... |.          . .||| .|||  |  ..| . |.   |.|  .   . || |.|  ||   |   | |..|| ... |.
ilr.ki..........rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1014-1226 3.9e-21 70.0 In-house 80-280 (290) alignment 
Range on Protein: 1014-1226
Range on HMM: 80-280/290.0
PSKYINASFIMSYwKPeVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK---QTYGDIEVDL-KDTDKSSTYTLRVFELRHS
.  |. | ..    |. ..| .||.||.|. |.|.|. | || .|||| ||    .  |.||. | .    |.|.| |   ...|| .   .... .|. 
dGdyvhanyvkGl.ka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk

KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknssegnkhhKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP
.   .  .. ..   |    ..     |. .......               | |. .||  |  .|| | |.   |.       .|. ..|.|||..| 
dsGkehklkhlkikswpdksvalstlallrtlrilrk..............asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrl

GMVSTFEQYQFLYDVIA
. |    ||  | ... 
nsvqvdiqylalveill
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 808-949 4.3e-21 69.8 In-house 88-230 (440) alignment 
Range on Protein: 808-949
Range on HMM: 88-230/440.0
GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS-NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIH
 | . . .. .|||.|||.    .||. . ||    .  .||..||||||.||||  | .|..|   .  ...|.. ..  .| .|  |||.  || ..|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQ
.|..|    |.| .   ..   .....  .| .. |||. ||.
eavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_ptpA1_pd Subfamily ptpA1 961-1184 5.5e-21 69.8 In-house 40-251 (418) alignment 
Range on Protein: 961-1184
Range on HMM: 40-251/418.0
HIGNQEENKSKNRNSNVIPYDYNRVPLKHeleMskesehdsdessDDdsdsEEPSKYINASFIMSYWkPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVM
  |... | |||| .|..| .. || ||.   .            .|    .| | |||| .|   . |. .|..|||| .|| |||.|... ....|||
segdkkhntsknrytnilpvnhtrvqlkk...i............qd....kegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivm

LTELKHGDQEICAQYW------------GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKL
|.      .  | .||            |.|.. .|   |.| .  .     .   ..| .   ..| . ||||  |   ..|   . .  ... . .. 
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

PQKNSSEgnkhHKSTPLLIHCRDGSQQTGIFCALLN
 |   |      .  |...||  |  .|| ||. . 
nqiipss....drnvpiivhcsagvgrtgtfctavi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 967-1097 5.8e-21 69.2 In-house 47-172 (349) alignment 
Range on Protein: 967-1097
Range on HMM: 47-172/349.0
ENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSdddsdSEEPSKYINASFI-MSYWKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTEL
|  .||| ....||.. || ||. |. || ...   ||      |  . .|||| .. ..  ..|   || | ||  |. ||...|   .||... |.. 
elfaknrykdilPyehsrvklkkslksskvikastsesd.....sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

KHGDQEICAQYWGEGkqTYGDIEVDLKDTDKSS
|  . | | .|| |.  .| .|.| |... . .
kelslekcdiywqel..sysnitvklqnsslyi
0044763 (Phosphotyrosine protein) phosphatases II 1012-1225 7.2e-21 70.1 In-house 15-167 (178) alignment 
Range on Protein: 1012-1225
Range on HMM: 15-167/178.0
EEPSKYINASFIMSYwkpeVMIAAQGPlketiGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQtygdievdlkdtdksstytlrvfelrhskr
.| | |||||.|. .    . .....|      |..... . ....||.||| ... .. | .|| |.                                
lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............................

kdsrtvYQYQYTNWSVEQLPAEPKELISMIQVVKQKLpqknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLESaeteEVvDIFQVVKALRKARPgM
      .||......    |  .. .  ... ... |          . |  | |.||. |   .| ..|.  ...      . ....... .|..|| .
......iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VSTFEQYQFLYDVI
| ...|...||.. 
vpnpgqlrqLyefe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 967-1226 1.2e-20 68.7 In-house 42-268 (288) alignment 
Range on Protein: 967-1226
Range on HMM: 42-268/288.0
ENKSKNRNSNVIPYDYNRVPLKhelemskesehdsdessdddsdsEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH
.| ...|  |.   |. || |.                       ..|  ||.|  . |   .. .| || ||. ||. .|.|...  |. ||||.||  
anptrdryenlprcditrvkls.......................ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

GDQEICAQYWGEGKQ---TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRT-VYQYQYTNWSVEQLPAEPKELISMIQVVkqklpqknssegNKHHKs
  .|  |.|.   .     .| .  . |.  .    ...|  || ||  . .  | .  . .|  . .| . .  . ...|.            ....| 
kGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl............kslqk.

tPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
 |...|.. |. .|| .   |  |||.  .. . | .... ||. |   . |  || ... .. 
.PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1015-1227 9.3e-20 65.8 In-house 67-275 (307) alignment 
Range on Protein: 1015-1227
Range on HMM: 67-275/307.0
SKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG--EG-KQTYGD----IEVDLKDTDKSS--TYTLRVFE
| || | ..    ||  .|.|||||..|. .|| |. | ||. ..|| ..    .  | |||   || |...|.    | |.   ..| .     . | .
sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvtt

LRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKqklpqknsseGNkhhkSTPLLIHCRDGSQQTGIFCALLNLLES-AETEEVVDIFQVVKAL
|.    ..|||. ..|..||  .  |      | ... |.          ..      |...||  |  ..|   |.  . .   . ..  |. ..|. |
lkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..........yd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveel

RKARPGMVSTFEQYQFLYDVIAS
|. |.  . |  || .|. |. .
rsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1018-1219 9.8e-20 65.5 In-house 78-271 (301) alignment 
Range on Protein: 1018-1219
Range on HMM: 78-271/301.0
INASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDI---EVDLKDTDK--SSTYTLRVFELRHS-KR
| | .| .  .|. .||.|||||.|  ||| |. | .|. ||||..     .|.|..|     .   ||   .. .|....  .   . | .|.. | ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknsSEgnKhhkstPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM
 ..|||  |||..|. ...|    ||  ....||.       ||  |     |...|| .|  ..  | .   |    |..  ... . .| ||. |   
fatrtvthyqysewtdrgvPkshaelfdlmelvkk.......se..k.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwng

VSTFEQYQ
| | .|  
vqtnsqly
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 668-831 1.1e-19 65.0 In-house 87-242 (244) alignment 
Range on Protein: 668-831
Range on HMM: 87-242/244.0
PIKEARKPFNQNKNRYVDILPYDYNRVELSeiNGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNrnkcaEYWP
 .|.| .| |  |||    ||.|.||| ||  .|  |  |||||..  .    .|| .| |  .|  |||.|. |..  |.|..   || .     ||||
vmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywp

SMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKaTGREVTHIQFTSWPDHGVPEDPHLL
  |       |. | . .     .    .|.|    .. . . .| .| . ||  |   . |..
dseplewyeeditvtltdrdefknikasnleiesdmne.shqaltmfqisnwpsdgttpndhfi
subfamily_hpo-7_pd Subfamily hpo-7 731-868 1.1e-19 65.3 In-house 45-176 (263) alignment 
Range on Protein: 731-868
Range on HMM: 45-176/263.0
ETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRcpDYIIQKLNIVNKKE-KATGREVTHIQFTSWPDHGVPEDPH
.|.| |...|  .|..|.||..  .| ...|| .|.|   .. . . .| |   . .   | ... |....  . | . ..|.| ... |...  ||...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

LLLKLRRRVNAfsnffSGPIVVHCSAGVGRTGTYIGIDA
  |.. . .       | ..|||||.|.||.  .  .. 
eilnilkvarn.....skslvvhcstGiGrsaafsvaEl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1010-1226 1.1e-19 65.2 In-house 75-286 (305) alignment 
Range on Protein: 1010-1226
Range on HMM: 75-286/305.0
DSEEPSKYINASFIMSYWKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW----GEGKQTYGDIEVD----LKDTDKSSTYT
|   ||.|| | ..     ||  .|.||||| .|| .|| |. |.||. ||||       .  |||||    || ..  . | |.     |  .. .   
dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiq

LRVFELRHSKRkDSRTVYQYQYTNWSVEQLPaePKELISMIQVvkqklpqkNSSEGNKhhksTPLLIHCRDGSQQTGIFCALLNLLES-AETEEVVDIFQ
. ...| .|   .. .| . |.|.|    .|  |  | |.  .         .  | |     |...||  |  .||   |.  .||  ||  ..  . .
itllnltysgd.qkmsvrhlqwtewpdrgvp..pckltslell........sairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpe

VVKALRKARPGMVSTFEQYQFLYDVIA
.|||||  |   . .  || |.. |. 
lvkalrdqrafsiqndvqylfihrvml
subfamily_egg_pd Subfamily egg 965-1240 4.9e-19 63.1 In-house 37-281 (307) alignment 
Range on Protein: 965-1240
Range on HMM: 37-281/307.0
QEENKSKNRNSNVIPYDYNRVPLKHELEMSKEsehdsdessdddsdseepsKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTEL
...|. | |.  |   |. || |. .  .  .                    .| |  .      . .| || |||.|  |||.|.|| .|. |||||  
sdnnlekarskrvhckdssrvklelrrGqyld...................dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr

KHGdqEICAQYWGEGKQ----T-YGDIEVDLKDTDKSSTYTLRVFELRHSKRK-DSRTVYQYQytnWSVEQLpaepKELISMIQVVKQKlpqknssegnk
|.   | |  ||   ..    |  | ....  . |. .   .|| .|.    . . | .  .|   . |...     .. | ..|...            
kes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnns....sdvysplrvlrkl...........

HHKSTPLLIHCRDGSQQTGIF----CALLNLLESAETEEVvdIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN
 . |.| .... .|  ... .     |||.||    |  .  . . |. ||. |.  |..  .| |.| ...  .    | .|. .
rnlskpvvvqdilGvskaatlvaieiallsllrGpitksl..vlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1016-1238 1.4e-18 61.9 In-house 60-278 (285) alignment 
Range on Protein: 1016-1238
Range on HMM: 60-278/285.0
KYINASFIMSYWK-PEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK---QTYGDIEVDLKDTDKSSTYTL--RVFELRHS
 || ||..    |     |..|||| ||. |||.||.| |.  ..||  |  |  | || |. |       .|  |. | .  . .        . .  .
dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvint

KRKDSRTVYQY-QYTNWSVEQLP-AEPKELISMIQVVKQKLPqknssegnkhhKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA
.   |  .|       |  .||   . . .| . . ||.  |           | .|. .||  |  .|  |  .         .  ......|. .|  
edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...........kekpicvhcsagvgrtatfvgidyatirimenpniemldivremram

RPGMVSTFEQYQFLYDVIAsTYPAQNGQVKK
|   | .. |. ||| |.   |   .| |..
rfqavqshmqflflyvvlm.eyfigegvver
subfamily_eak_pd Subfamily eak 670-914 2.7e-18 60.4 In-house 45-306 (332) alignment 
Range on Protein: 670-914
Range on HMM: 45-306/332.0
KEARKPFNQNKNrYVDILPYDYNRVELSEINGDAgSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSM
.|...  . |.|  |.|.|||.. |.|.    .    ||||| ..  .  |||| .  .... |  ||.|. |||.  ||..    | . .|   |.|  
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

EEGTRAFGDVVVKINQHkrCPDYIIQKLNIVNKKEKATgREVTHIQFTSWPDHGVPEDPHL--LLKL----------RRRVNAFSNFFSG--------PI
      || . |.  ..      |..  ... .|   |  .| | ..  | .  .|    .  | |             . . .| ..            
treelkfGildverkef..vkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap

VVHCSAGVGRTGTYIGIDAMLEGLEA--ENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQ
.. .. |  |.|... || ... ...  .|   |  ...| . .|   | |. |. .|......| .
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1016-1234 4.6e-18 60.4 In-house 47-263 (290) alignment 
Range on Protein: 1016-1234
Range on HMM: 47-263/290.0
KYINASFImSYWKPEVMIAAQGPLKET-------IGDFWQMIFQRKVKVIVMLTELKHGDQE----ICAQYWGEGKQ---TYGDIEVDLKDTDKSSTYTL
 || |... .. .   .|. | |....       | .|| |. | ||| .||| | .  ...     ||.|  |      ......|  |.  |      
dyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RVFELRHSKRKDsRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknssegnkhhKSTPLLIHCRDGSQQTGIFCA-LLNLLESAETEEVVDIFQV
|  .... ....  ||  ... .|.  . . ..| |.|.|| ||.              . || ..|| ||  .  .. |  |     |||.. | . .|
Relvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvka..............sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

VKALRKARPGMVSTFEQYQFLYDVIAsTYPAQNG
.||||| |  .... ... |   .|   .  . .
lkalrkqralaitsalelafvdagiv.llaievl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 647-911 1.5e-17 58.1 In-house 18-277 (303) alignment 
Range on Protein: 647-911
Range on HMM: 18-277/303.0
ADEGRLFLAEFQsipRVFSKFPIKEARKPF--NQNKNRYVDILPYDYNRVELSEingdagSNYINASYIDgFKEPRKYIAAQGPRDETVDDFWRMIWEQK
 ..  .   ||.   .| | .| . ... |  | .|||.||..  |. .|.||.      | || |||.. ..  .| | .| |   |  |||.|| |||
dedaniavnefe...kvvsylppsvsknqfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqk

ATVIVMVTRCEEGNRNKCAEYWPSMEEgTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKeKATGREVTHIQ-FTSWPDHGVPED--PHLLLKLRRRVNAF
  .....    | ..      .|  ..    | . .... . ||       .|...    . . .   |.. . .||   .| |  |... .. .    .
vkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvl

SNFF-SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEN-KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE
 ..  | | |    .|.||.||.  ...    | .|.  .|.   . ..|  |   ||  .|. ...  | |
rkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1011-1233 6e-17 56.0 In-house 71-288 (302) alignment 
Range on Protein: 1011-1233
Range on HMM: 71-288/302.0
SEEPSKYINASFIMSYWKPEVMIAAQGPLKETI---GDFWQMIFQRKVKVIVMLTELKHGDQ---EICAQYWgEGKQTYGDIEVDLKDTDKSSTYT-LRV
..|| .|.||| .      . .| || | ...     .||.|.||.|.. .|.|   .  ..   |.  .   .  ..||.. |  .  .|..  .   |
eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkks.gdykeygkmfvNnrkVekaeeektryv

FELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVkqklpQKNSSEGNKHhkstpLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA
 |.      .|  .  |  ||| ... | .  |||  .. |      .........     ..|    |.   |.| .|   .|. .... . | ..||.
iEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.....fakkikaden.....tvivSknGaGRagafltlavaveklqkgkepnikeivks

LRKARPGMVSTFEQYQFLYdVIASTYPAQN
.|. || .| ...|| .|| ... .|  ..
iRsqRpravdslkQyvsly.ialllyikkk
PTP_N Protein tyrosine phosphatase N terminal 7-34 6.8e-17 47.2 Pfam-A 1-28 (28) alignment 
Range on Protein: 7-34
Range on HMM: 1-28/28.0
LKLLAFGFAFLDTEVFVTGQSPTPSPTG
||||||||||||..|||||||.|||..|
LkllafGFafLdpdvfvtgqsqtpsasG
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 677-912 1.5e-16 54.7 In-house 51-284 (302) alignment 
Range on Protein: 677-912
Range on HMM: 51-284/302.0
NQNKNRYVDILPYDYNRVELSEingdAGSNYINASYIDGFKEPRKYIAAQGPRDETV---DDFWRMIWEQKATVIVMVTRCEEGNRnKCAEYWPSMEEGT
| .||.  |.  .| |.| |..    .  .|.||| ..  .  |. | || |  ...   ..||||....| . .|.. . || ..    |..|   .  
nlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

RAFGDVVVKINQHKRCPDYI-IQKLNIVNK-KEKATGREVTHIqfTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE
  .|.. | . . ..  .      . .. .    .   .|...  | |... ||.    | |    | | .   . ..|.    |.|| |. .   . .|
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY
 |...... .   | ..| ||. .|.   ||. .. ||. |
klqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 849-916 2.6e-16 53.7 In-house 1-68 (69) alignment 
Range on Protein: 849-916
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFG
.|||||.| |||||.| |   .  . .|  ||..  |  .|. | .||  | .||.|| ||||  ..|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1026-1233 3.6e-16 54.0 In-house 39-226 (255) alignment 
Range on Protein: 1026-1233
Range on HMM: 39-226/255.0
YwkpevmiaaqgplkeTIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDtdKSSTYTLRVFEL--RHSKRKDSRTVYQY
                |.  |.|.| | | .|.|||....  ..| | .|.    ..|. . |..|   .   |.   ||  |.    ...|  .||  |
l...............tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhy

QYTNWSVEQLPAEPKELISMIQVVKqklpqknssegnkhhKSTPLLIHCRDGSQQTGIFCA-------LLNLLESAETEEvVDIFQVVKALRKARPGMVS
.|. |  .. | ...|.  ...||.               .| ....||  |  ..  |         ..  |. .|| | .|  .... ||. |.. . 
sykGWieknaPelareilnilkvvr...............dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetve.ldylslleelrskrkraih

TFEQYQF-LYDVIASTYPAQN
|  |  | .. |.   .|...
tPlqlafsilmvldlvfpkge
0048076 (Phosphotyrosine protein) phosphatases II 1102-1225 1.2e-15 52.9 In-house 32-139 (145) alignment 
Range on Protein: 1102-1225
Range on HMM: 32-139/145.0
RVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQknssegnkhhkSTPLLIHCRDGSQQTGIFCALLNLLEsaetEEvVDIFQVV
.|. | . ..  .|...||.|..|   . |  .. |..... ... |..             | |.||. |   || ..|.  .|.    .  |......
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KALRKARPGMVSTFEQYQFLYDVI
. .|..|||.| ...|..|||...
elvrsqrpgavpnpgqlrflyefe
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 850-916 2.1e-15 50.8 In-house 1-67 (69) alignment 
Range on Protein: 850-916
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFG
|||||.| |||||.| |   .  . .|  ||..  |  .|. | .||  | .|..||.||||  ..|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 810-914 2.2e-15 51.2 In-house 216-345 (350) alignment 
Range on Protein: 810-914
Range on HMM: 216-345/350.0
EVTHIQFTSWPDHGVPEDPHLLLKLRR----------RVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEG---L----EAENKVDVY--------GY
.| ..|.  |.| ..  .|. .|.               . . |  | ||.||||||||||||.. .| .|.    |    .  .|.||           
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VVKLRRQRCLMVQVEAQYILIHQALVEYNQ
| .||.||  |||   |.| |..||  |..
vnelrkqrismvqnldqfifiYeallfyfa
subfamily_CG42327_pd Subfamily CG42327 846-915 1.4e-14 48.5 In-house 247-317 (319) alignment 
Range on Protein: 846-915
Range on HMM: 247-317/319.0
SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAE-NKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF
 ||.||||| ||||||. |  |  .. ||   . ||.   |  .||.|.  |.   || .|.. | || ..
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1116-1226 2.6e-14 47.7 In-house 216-341 (350) alignment 
Range on Protein: 1116-1226
Range on HMM: 216-341/350.0
TVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLE-----SAETEE---------VVD-IFQV
 ||| |. ||    |  .|........| .. . . .. .  .  .|.|.|.||  |  .||....|  ||.     .  |.|         . | |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKALRKARPGMVSTFEQYQFLYDVIA
|. ||| |  || . .|. |.|. . 
vnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1037-1225 2.9e-14 47.2 In-house 98-284 (302) alignment 
Range on Protein: 1037-1225
Range on HMM: 98-284/302.0
GPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE---GKQTYG-------DIEVDLKD-TDKSsTYTLRVFELRHSKR--KDSRTVYQYQYT
 | |.|.  .| .| | .| ..| |.... .... ||.|. .   |. ..|       ... ||.. |||  ...|   |.. .|.  |  .||   ...
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkk.sfklytveiknekkkkkvkktvdilafs

NWSVEQLPAEPKELISMIQVVkqklpqknssEGNKhhksTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYD
 |     |.|..  . ...            |  |    . .|.||  |  .|| . |.   ..   ...| |. ..|. .|. | | | . .|  .|  
awpdhGapkeaytaldilkfc..........esyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

VI
..
cv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 679-768 3.5e-14 46.9 In-house 50-155 (349) alignment 
Range on Protein: 679-768
Range on HMM: 50-155/349.0
NKNRYVDILPYDYNRVELSE--------------INGDAGSNYINASYID--GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKC
 |||| |||||.. || | .               ..    .|||| |.    ..  .|||| | |   |||||...|  ..  ... ..  .| . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

AEYWPS
  ||  
diywqe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1015-1221 4e-14 46.9 In-house 79-282 (310) alignment 
Range on Protein: 1015-1221
Range on HMM: 79-282/310.0
SKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGE--GKQTYGDIEVDlkDTDKSSTyTLRVFELRHSKRK
  || | .. . .  . .| .||||. || |||.|||| . . |..|    .  .  |  ||      .||| | |   .  .||   . . .|  .   
edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvt..nlsesse.efeicnlavtfvp

DSRTVYQ----YQYTNWSVEQLPAEPKELISMIQvvKQKLPQKNSSEgnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKAR
|   | .     .    |. . |  |   .   .   . .||.  ..     .  | ..||  | ..... .||   .. ..  . ||. .|.  |.| |
dnvpvdeqpanlkelrvslikwpnwpdrgvpdek..chtvpqrllaq....vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr

PGMVSTFEQYQFL
   . |  || ..
aiciqtelqylii
0048179 (Phosphotyrosine protein) phosphatases II 1110-1223 5.2e-14 47.7 In-house 42-139 (144) alignment 
Range on Protein: 1110-1223
Range on HMM: 42-139/144.0
KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKlpqknssegnkHHKSTPLLIHCRDGSQQTGIFCALLNLLesaeTEEvVDIFQVVKALRKARP
.    |...||....|   . |  .. |..... ...            . .. | |.||. |   || ..|.  ..    ..  ........ .|..||
pefleregiqylhlpwpDhgvpdllellleflefieea...........leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

GMVSTFEQYQFLYD
|.| ...|..||..
gavpnpgqlrfLle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1013-1227 1.5e-13 45.2 In-house 71-285 (305) alignment 
Range on Protein: 1013-1227
Range on HMM: 71-285/305.0
EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDI-EVDLKDTDK---SSTYTL-------
 | .|| | .. .  .|. .| .| ||..|  ||| | .| ||. | || .|.    . |..|.   ..   .. | . | . |   |.|. .       
wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

---RVFELrHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIqvvKQKLPQKnsseGnkhhkstPLLIHCRDGSQQTGIFCALLNLLESAETEEVV-DI
    |. .     ...| | .| . .|    .||    .. ..   ..  | |    |       |. .||  |  .||    |  .|.   . ... | 
vtetvlvi.egpgekarkvthyhwidwpdrgvpaadlailell...ekarpsk....g.......pivvhcsagigrtgsvvmleyildqllagqiiedt

FQVVKALRKARPGMVSTFEQYQFLYDVIAS
 .... .|. |   . | .|| |...||  
dkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1016-1256 2e-13 44.7 In-house 68-300 (312) alignment 
Range on Protein: 1016-1256
Range on HMM: 68-300/312.0
KYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG--------EGKQTYG----DIEVDLKDTDKSSTYTLRV
 || | |.    ||| ....||||..|.  |||. .      |..|. . .   | ||.|          | .. |     .||.  |  || .   |.|
fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkv

felRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQklpqknssegnkHHKstPLLIHCRDGSQQTGIFCAL---LNLLESAETEEVVDIFQV
         .   . .||.. |    .|        ..  ||.             .|  |.. ||  |  .|| .. .   .  |     ..| |.| .
...vvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk............dkk..pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl

vkaLRKARPGMVSTFEQYQFLYDVIAStYPAQNGQVKKNNHQedKIEFDNEVDKVK
   ||| |   | .| || .   ..   .   .|  |.|...    .| .   |.|
...lrkdrarsvrvfpqyvyalrcvle.flyskglykrneqe..wtkfketyakik
subfamily_hpo-7_pd Subfamily hpo-7 1024-1220 1e-12 42.6 In-house 42-218 (263) alignment 
Range on Protein: 1024-1220
Range on HMM: 42-218/263.0
MsywkpevmiaaqgpLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG---EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQY
.              | .||  |.|.| | | .|.|||.. .  ..| | .|.    ..|| . ...|   .. .      ...    ...|  .|| .|
l..............lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhy

QYTNWSVEQLPAEPKELISMIQVVKQKLP-QKNSSEGNKHHKStpllihcrdGSQQTGIFCALLNLLESAETEEvVDIFQVVKALRKARPGMVSTFEQYQ
.|. |  .. | ...| . ...|...  .     |.|     .          | .  ..  ..  |. ..| | .|  .... ||. |.. . |  |  
sykgWiekndpelareilnilkvarnskslvvhcstGiGrsaa.........fsvaElvyqkmirsldttstve.ldylsLleelrssrkraihtPmqLa

F
|
f
PTP_N Protein tyrosine phosphatase N terminal 35-62 1.7e-12 33.1 Pfam-A 1-28 (28) alignment 
Range on Protein: 35-62
Range on HMM: 1-28/28.0
LTTAKMPSVPLSSDPLPTHTTAFSPAST
|.........|..|...|.......||.
LkllafGFafLdpdvfvtgqsqtpsasG
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1116-1225 1.5e-11 38.3 In-house 219-340 (349) alignment 
Range on Protein: 1116-1225
Range on HMM: 219-340/349.0
TVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLE--SAETEEVVD----------IFQVVKA
 ..| |. ||    |  .|. ..  ..| .. . ....    .  ....||.||  |  .||... |  ||.  .  ..| .           |. .|  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRKARPGMVSTFEQYQFLYDVI
||| |  ||  . |. ..|. .
lrkqrismvqnlaqfiaiyeal
subfamily_eak_pd Subfamily eak 1011-1237 1.6e-11 38.2 In-house 74-313 (332) alignment 
Range on Protein: 1011-1237
Range on HMM: 74-313/332.0
SEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK---QTYGDIEVDLKDTDKSSTYTLRVFELR
  ..  ||||| .      .  | .  . .. .  ||||....|   ||.| |    . |   .|. .       .| ..|. |.  | . .  | .||.
qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels

HSkrKDSRTVYQYQYTNWSVEQLPAEpKELISMIQVVKQK----L--PQKN--SSEGNKHHKSTP---LLIHCRDGSQQTGIFCA---LLNLLESAETeE
     ..  |. |..  |.  .||   ...... .|.|.     |  ....  ||  .|.... |    .| .  || ..|.|     |..|...  . .
kG..nethrvlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkk.n

VVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVK
.  . ...   .. |   | .  |. |.|...      .| ...
lysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1014-1253 2.2e-11 37.9 In-house 68-302 (303) alignment 
Range on Protein: 1014-1253
Range on HMM: 68-302/303.0
PSKYINASFIMSYWKpEVMIAAQGPLKETIGDFWQMIFQRKVKVIV-MLTEL---KHGDQEICAQYWGEGKQTYGDIEV-DLKDTDKSSTYTLRVFELRH
 | || ||..    .    | .| ||  |  |||||| ..|||... .||.    | | . .  .     |     | | ..|  . .  ..|.|  .  
dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn

SKRKDSrtVYQYQYTNWSVEQLPAEPKElismiQVVKQKLpQKNsSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE-EVVDIFQVVKALRKA
 . |    .. ..| .|  ...|..        ..|||   | . |   |. .||| .     |  ..| |. .     |  .|   .|. .... .|. 
gdyksf..lhvhhykawphnsipsdgsp.....kfvkqiw.qlq.svlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrng

RPGMVSTFEQYQFLYDVIASTYpAQNGQVKKNNHQEDKIEFDNEVD
|   |  . |. ..| ..|     .|| .|    .. . | |.| |
rlhavqnlsqfsvvytllaehv.ldngicklaipkkpndekdkekd
subfamily_CG42327_pd Subfamily CG42327 1153-1226 2.2e-11 38.0 In-house 238-312 (319) alignment 
Range on Protein: 1153-1226
Range on HMM: 238-312/319.0
SSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE-EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
||   ....  || .|| ||  .||.  |    ..| |.  . ||| |.|  .|. |   | | |||.|.| |. 
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 687-824 2.3e-11 38.1 In-house 3-126 (130) alignment 
Range on Protein: 687-824
Range on HMM: 3-126/130.0
LPYDYNRVElseingdaGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNrnkcaEYWPSMEEGTRAFGDVVVKINQH
|.....|..        | .|||||..      ..|. .| |  .|  |||.|. |.   |.|..   || .     ||||  |       |..| . ..
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

KRCpDYI-IQKLNIVNKKeKATGREVTHIQFTSWPDHGV
.   ..|  ..|.| ..  . . . .| .| . ||  | 
def.knikasnleiesdl.neshqaltmfqisnwpsdgt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 967-1127 3e-11 37.4 In-house 95-232 (244) alignment 
Range on Protein: 967-1127
Range on HMM: 95-232/244.0
ENKSKNRNSNVIPYDYNRVPLkhelemSKESEHdsdessdddsdseepSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH
.|  |||..  .|.|.|||||      || |                   ||||||.    .    | .| || .|  |||.|...|.|.|.|.|  .. 
nnswknregaglpfdfnrvpl......skgsmg...............ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee

GDqeicaQYWGEGK--QTY-GDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSV
 |     .|| . .  . |  || | | | |.        .|.     .  ...  .| .||  
ed.....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 631-727 4.2e-11 36.9 In-house 3-95 (95) alignment 
Range on Protein: 631-727
Range on HMM: 3-95/95.0
EPIHADILLETYKRKIADEGRLFLAEFQSIPrVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEingDAGSNYINASYIDGFKEPRKYIAAQG
 |||  ..        ..  . |  ||.||. . |  |        |  |||...|.|||  || |.       |.|||| ..||.     ||||||
kpihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 810-913 6.4e-11 36.2 In-house 219-344 (349) alignment 
Range on Protein: 810-913
Range on HMM: 219-344/349.0
EVTHIQFTSWPDHGVPEDPHLLLKL----------RRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL----EAENKVDVYG--------YVVK
|.  .|.  |.| ..  .|  .|.               . . .  . ...|||||| ||||... .| .|. |    .  ||...           | .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRRQRCLMVQVEAQYILIHQALVEYN
||.||  |||  ||.| |..||..| 
lrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 677-762 9.1e-11 35.8 In-house 34-118 (332) alignment 
Range on Protein: 677-762
Range on HMM: 34-118/332.0
NQNKNRYVDILPYDYNRVELSEINGDagSNYINASYIDGFKEPRKYIAAQGPR-DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKC
| . ||   .  .|..||||.  .|    .. |||..||. .   || || |  | |   ||||. |.| ..|...   .| .. |.
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1167-1226 9.1e-11 36.0 In-house 2-61 (69) alignment 
Range on Protein: 1167-1226
Range on HMM: 2-61/69.0
IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
.||  |. .|| | |..  .    .| .||||  |. .|| || ||   ..| |..| ..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1166-1226 1e-10 35.9 In-house 2-62 (69) alignment 
Range on Protein: 1166-1226
Range on HMM: 2-62/69.0
LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIA
..||  |. .|| | |..  .    .| .||||  |. .|| || ||    .| |..| ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 650-717 1.8e-10 34.8 In-house 21-87 (440) alignment 
Range on Protein: 650-717
Range on HMM: 21-87/440.0
GRLFLAEFQSIPRVFSKfPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFK
 | |  |.  .|  .|. | . |  | |. |||| .|| ||..|| | |..|   |.|||||||.| .
srafedewsllpsglsq.psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 848-909 5.6e-10 33.6 In-house 230-291 (297) alignment 
Range on Protein: 848-909
Range on HMM: 230-291/297.0
PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL
...|||||||||.|  .  |..|. |  .   ||   . .|| ||  .||   |. |...| 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 964-1248 1.7e-09 30.8 In-house 46-327 (346) alignment 
Range on Protein: 964-1248
Range on HMM: 46-327/346.0
NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSD----SEEPSKYINASFIMSYWKPeVMIAAQGPLKE---TIGDFWQMIFQRKVK
. | || .||..    || ||| |..      .    |  .  | |          . .   |..  ..   .| || |  |    . ||| ||.| ...
dfeankvrnregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfeh.klivaqlpqmenesfvedfwymiyqeqih

VIVMLT---ELKHGDQEICAQYWGeGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPaePKELiSMIQVVKQKLPQKNs
.. ..     ||     .  .  | | |  | . .. . .| |        |.      ||  .  .... |   | |  || |  .|....| | .|. 
lvylmvpddklkntttslfndeng.gyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqp..pktl.piikmihqflsekq.

segnkhHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAsTYPAQNGQVKKNNHQEDKIEF
       ... . .    |. ..  |   |  ..  .     .|....|.... ||| | .| ||  .| ..   | |.    ||.  . |   |
......vqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf.dyiarkrggkkapvnkdinrf
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 676-771 6.1e-09 29.0 In-house 26-89 (169) alignment 
Range on Protein: 676-771
Range on HMM: 26-89/169.0
FNQNKNRYVDILPYDYNRVELSEINGDAGSNYINAsyidgfkeprkyiaaqgprdetvddfwRMIWEQKATVIVMVTRCEEGNrnkcaEYWPSMEE
 |. |||    |   . ||.|  .  | ||.||||                           |||||  |.|||..  ... |     ..||  |.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpeked
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 676-771 9.2e-09 28.3 In-house 25-88 (169) alignment 
Range on Protein: 676-771
Range on HMM: 25-88/169.0
FNQNKNRYVDILPYDYNRVELSEINGDAGSNYINAsyidgfkeprkyiaaqgprdetvddfwRMIWEQKATVIVMVTRCEEGNrnkcaEYWPSMEE
 |. |||    |   . ||.|  .  | ||.||||                           |||||  |.|||..  ... |     ..||  |.
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpeked
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 669-753 1.1e-08 29.1 In-house 31-118 (347) alignment 
Range on Protein: 669-753
Range on HMM: 31-118/347.0
IKEARKpfNQNKNRYVDILPYDYNRVELSEIN-----GDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR
 .|  |  . .|||  |    |  || ||  .      |   .|||||.|   .  ..|| .| |  .|| |||.|.   | | .| .  
svewek..slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
fn3 Fibronectin type III domain 395-462 2e-08 27.4 Pfam-A 3-76 (85) alignment 
Range on Protein: 395-462
Range on HMM: 3-76/85.0
PQIIFCRSEAAHQGVITWNPP---QRSFHNFTLCYIKETEKD---CLNLDKNLIKYDLQNLKPYTKYVLSLHAY
|. . ...  ... ...|.||   .. . .... | .... .     .....   . |..|||.|.|.....|.
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 965-1064 2.4e-08 27.9 In-house 34-119 (347) alignment 
Range on Protein: 965-1064
Range on HMM: 34-119/347.0
QEENKSKNRNSNVIPYDYNRVPLKheLEMSKESehdsdesSDDdsdseEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTEL
 | . ||||  .|   |  || |    | || |         |     ..  ||||| |      . .| .| || .|. |||.|..  ||  .| . | 
wekslsknrskdvklidatrvvls..pekskns.......rad.....dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1015-1127 2.6e-08 28.3 In-house 13-123 (130) alignment 
Range on Protein: 1015-1127
Range on HMM: 13-123/130.0
SKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDqeicaQYWGEGKQTY---GDIEVDLKDTDKSSTYTLRVFELRHSKR
 .||||||.    .    . .| || .|  |||.|...| | |.|.|  ..  |     .|| . .       || | | | |..       .|  .   
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdln

KDSRTVYQYQYTNWSV
.  ...  .| .||  
eshqaltmfqisnwps
fn3 Fibronectin type III domain 486-564 9.6e-08 25.3 Pfam-A 1-83 (85) alignment 
Range on Protein: 486-564
Range on HMM: 1-83/85.0
SQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTL--VRNESHKNC--DFRVKDLQYSTDYTFKAYFHNGDYPGE
|.. |..|| ....|....  ||.|..|| ..| .|..  ..    .. . ..    . ...|. .|.|.|. . .||.. |.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
0038934 (Phosphotyrosine protein) phosphatases II 804-865 1.3e-07 27.0 In-house 73-134 (194) alignment 
Range on Protein: 804-865
Range on HMM: 73-134/194.0
EKATGREVTHIQFTsWPDHGVPEDPHLLLKLRRRVNAF-SNFFSGPIVVHCSAGVGRTGTYIG
|. ... ......  .||.|.. .  .||.  . |. | ..  .| ..||| ||.||||| ..
eefekagieylklp.fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 714-781 1.4e-07 25.3 In-house 230-293 (440) alignment 
Range on Protein: 714-781
Range on HMM: 230-293/440.0
DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCeegNRNKCAEYWPSMEeGTRAFGDVVV
.|.     .||.| | | || ||||.. . . . |.|. .    | . |. |||     . .||   |
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt.rsvtfgpftv
PTEN_1 818-862 3.4e-06 22.0 In-house 101-146 (196) alignment 
Range on Protein: 818-862
Range on HMM: 101-146/196.0
SWPDHGVPEDPHLLLKLRRRVNAFSNFF-SGPIVVHCSAGVGRTGT
...|||.|   .|.  ...  .. ..    . ..||| ||.||.||
pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt
subfamily_PTPDC1_pd Subfamily PTPDC1 802-906 5.6e-06 20.9 In-house 74-169 (182) alignment 
Range on Protein: 802-906
Range on HMM: 74-169/182.0
KKEKATGREVTHIQFtSWPDHGVPEDPHlLLKLRrRVNAFSnFFSGPIVVHCSAGVGRTGTYIGIDAMLegleaENKVDVYGYVVKLRRQRCLMVQVEAQ
..|. . ..... .| .|.|.||.   . .| .  .| ||.    | . ||| || ||||  |    .       ....    . ..| .|   .|   |
dlealmeqgiyvynf.gwkDygvasler.iLdiv.kvvafa.lqegkvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreq

YILIH
  |..
velvk
subfamily_CDC14_pd Subfamily CDC14 843-869 9.2e-06 19.7 In-house 260-286 (328) alignment 
Range on Protein: 843-869
Range on HMM: 260-286/328.0
NFFSGPIVVHCSAGVGRTGTYIGIDAM
.  .| |.||| ||.||||| |.   |
ekaeGaiavhCkaGLGrtGtLiacylm