Gene PTPRD in Homo sapiens

Synonym: HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA, PTPRD

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP096_AA protein Get Run
HsapP096_AA_1359-1634 phosphatase_domain Get Run
HsapP096_AA_1646-1925 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1354-1684 9.5e-174 574.1 In-house 2-333 (564) alignment
Range on Protein: 1354-1684
Range on HMM: 2-333/564.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|||. ||..|...||||..|||..||..|..|||||||..| ..||.||||||..||||||| ||..|| .||||.||..||||||..||||||| |.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLA
||. |||||.|||.|.|.||.|||||...|||..|||..||||.| ..||| ...|||.|..||| | |. |||.||||||.||.||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
..|.|...|.|||||.||||||||||||.||||||||||||.|||||||..|...|.|||.|||||.||||||.|.|||..||||||...||.. .|||.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QIETGENVTGMELEFKRLA-SSKAHTSRFISA
..|.....||.||||.||| ... ....| .|
eveedtemtgleleFqrLatakeieleefava

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1357-1671 1.7e-135 446.2 In-house 2-318 (318) alignment
Range on Protein: 1357-1671
Range on HMM: 2-318/318.0
IPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|.. .|..|..||... .|..|.||| ...  ...|. .|. .||| ||||||..||||.||.|. .|| .||||.|||||||||...||||.|. ||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
. |||||.||| ||..||.|..|||...|...||||.|....| ..|.| ..|||..| .|.| . .....|.|.|||...|.|||.||||... .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQ
|.|.. . ...|||.|||||||||||| ||..|..|||||.|..||... |. .| ||| ||||||||.||.|.||||...|.||| |..| . |..|..
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

IETGENVTGMELEFKRL
 ..    | |..||.||
qdpesgttemdaefqrl

subfamily_PTPRD_pd Subfamily PTPRD 1677-1929 5.2e-129 426.4 In-house 36-286 (564) alignment
Range on Protein: 1677-1929
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|...||.|....|.|||||||||||||||..|||||||||||||.||||||.||.||...||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||.||||.||.||..|||.|.....|.| .|....|   . ||| |||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH
....|||...|..|||.|.||.||.||.||||||.||.| ..| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1356-1669 1.6e-118 390.5 In-house 4-319 (319) alignment
Range on Protein: 1356-1669
Range on HMM: 4-319/319.0
PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
.|.. ||......|... . .. .|.. .. ....|..... | ||.|||| |..|||..|| ||...|..||||.||..||||......||||. | .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN-GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF
. |||||.||..| .|||.||| |. .||. .|||.   |. | . |||..  ||. | .| . | |. .  | ||| .||.|.||||.|||. |  |..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
|.|..     ...||.|||||||||||| |||.||||||.|.| ..|..  |  .|.||| |||...||.||..||||||..|.||.  ..|   ...|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QIETGENVTGMELEFK
. ...   ||.| ||.
ekvadtgetglerefq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1662-1931 6.4e-116 381.9 In-house 20-287 (318) alignment
Range on Protein: 1662-1931
Range on HMM: 20-287/318.0
TGMELEFKRLASSKAHTSRFISaNLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
. .. |..||. |....... | . |.||.||| .||..|..||| ||.. |.||||||||..|||||..|||||.|.||.|| ||||||.|| ||...|
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdGPIS
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||.|||...|.||..|||.|| ...|...||.|.... |. ||| 
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..||||||||.| | . ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

subfamily_PTPRG_pd Subfamily PTPRG 1357-1647 8e-115 379.2 In-house 1-301 (563) alignment
Range on Protein: 1357-1647
Range on HMM: 1-301/563.0
IPILELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGS-DYVNANYIDGYRKQNAYIATQGSL
.|. |.| |.  |.|... .||.|.|..      .... |||. . || |||| |..|||.||| || . |. .. ||.||||||||.|..|.|||||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK----NGSS--EKREVRQFQFTAWPDHGVPE
..|| |||||||||..|..||.|.|.|| | |||.|||. ..|| | .|||| ..  ||.| |||. . .    ....  ....|||...| ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY
|..| | | .. .. |. .|||.|||||||||||| .||.|..|..|..|..|...| .  .|||||..||||.||||.|||||||.. ..||. | .. 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

A
.
e

0040438 (Phosphotyrosine protein) phosphatases II 1360-1671 2.2e-111 367.4 In-house 3-314 (317) alignment
Range on Protein: 1360-1671
Range on HMM: 3-314/317.0
LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF
|.| .....|...|. ....|.| ..  .  |.....|..||.|||| ... |||||| || ..|...|||.||.|.||.......||||| ||.|..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK
|||.|||.. ..||.|.|||..|.||.||||...| |.| ..||||...||| ...||. ....|.||.|.|..|..|.|||||||..|...|.||..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGE
...... ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|..||||| .....| .|| .|. ...||... ...
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

NVTGMELEFKRL
.|...| |.|.|
dvklkekelkll

subfamily_PTPRA_pd Subfamily PTPRA 1352-1668 5.6e-111 365.6 In-house 9-330 (330) alignment
Range on Protein: 1352-1668
Range on HMM: 9-330/330.0
ASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG
  ..|.|. .| . |.. .|.|| .| .|....     | | | .. | || |||. |.. ||.||| || .||.. |||.|| .||||.... .||.||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS----SEKREVRQFQFTAWPDHGVPE
 . ||  |||||||||.|||.||.|.|.|| . || ||||. |. |.| ..|.. |...|  | || | . . .      ..| |||| ||.||| ||| 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

HPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY
.|   | .|..||..|.  |||.|||||||||||| |||.||.|||.| |. ||... |  .|.||  ||||. || ||. .|||    |.||. .  | 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

AYIQKLTQIETGENVTGMELEF
 ..||| .  || . .|.| ||
khlqklynkitgtdkigleeef

subfamily_PTPRK_pd Subfamily PTPRK 1354-1669 1.1e-110 364.3 In-house 1-313 (314) alignment
Range on Protein: 1354-1669
Range on HMM: 1-313/314.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGqqftWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
|| | . .| ..|  ||....  | .||||.  |    |. .. . |. |||. ...|||.||| | .|.| | |||.||..||.|.. .|.|.||| |.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTEtHGLVQVTLLDTVELATYCVRTFALYK--NGSSEKREVRQFQFTAWPDHGVPEHPTPF
||  ||||.......|..||.|.| | .|||| .|||  ..  .| ..|.|..|  || . ||.|...|   | .|.||||||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK
|...||||. ....||..||||||| ||||.||.|| .|. |..|..||..  |  .|...  ||.||.||.||.|..|||. ||.| .|. .. |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LTQIETGENVTGMELEFK
 .....  | . .. ||.
sirldpqtnssqlkeefq

0051299 (Phosphotyrosine protein) phosphatases II 1354-1633 1.1e-107 355.1 In-house 2-286 (288) alignment
Range on Protein: 1354-1633
Range on HMM: 2-286/288.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSL
. .|.. ||......|.||.. .. .|.| . . . ..|. ...|. |..|||| ....|||||| || ..|..||||.||.|||||......||||| |
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN----GSSEKREVRQFQFTAWPDHGVPEHP
|.|..|||||.|||.. ..||.|||.|..|.||.||||..|..|.| ..||||....|..|.|||. . ..    |..|.|.|..|..|.|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
...|.|||.|....... ||.||||||||||||.||..| .||....|..||... |  .| ||..||||..||.|...||||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRB_pd Subfamily PTPRB 1355-1635 6.2e-107 352.0 In-house 5-287 (293) alignment
Range on Protein: 1355-1635
Range on HMM: 5-287/293.0
PPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
 || . ....|....||...|.||.|||..   |.. . . ..|.||. |||| |...|||||| |.|... .||||.|||||.||. .. .||||| ||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHPTPFL
||. |||||.||..| ..||.|.| |. .|||..|||.   . ..| ..|||. . ||  . .|.... |  ..|.|.|||..||.||||||||.....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKTCN--PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
.|.|.|..      ...|.|||||||||||| || .| .|..|..| .|||.| |. .| .||..||||.||||||...|. .. 
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0050432 (Phosphotyrosine protein) phosphatases II 1348-1637 4.9e-106 349.8 In-house 17-303 (308) alignment
Range on Protein: 1348-1637
Range on HMM: 17-303/308.0
SSSMASHPPIPILELADHIERlkANDNLKFSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaieGiPGSDYVNANYIDGY--RKQNA
 | ..|. ....|.|. ..|.  |.|. ....|.| .   .  .......|. ||.|||| ....|||||| |    . .||||.||.|.|||  .....
tsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprk

YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR---GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD
.||||| ||.|..|||||.|||.. ..||.|||.|..|.||.||||.    |....| ..||||.. .|..|.|||. | ..|..| |.|..|..|.|||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

HGVPEHPTPFLAFLRRVKTCNPPdaGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
||||..|...|.||..|....|.  ||.||||||||||||.||..| .||....|..||... |  .| ||..||||..||.|...|||| . .  
hgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0050432 (Phosphotyrosine protein) phosphatases II 1631-1929 4.5e-104 343.3 In-house 10-304 (308) alignment
Range on Protein: 1631-1929
Range on HMM: 10-304/308.0
EAVTCGNTEVPARNLYAYIQKLTQ-IETGENVTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGvEGSDYINASFIDGY-
|......|.... .|. ....| . .|   . ...| ||..| | |     . .|.||.|| ||| ..|.||...||.|    . |||||||||..||| 
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgys

-RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
 ......||||||| .|.||||||.||.|....|||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.||||..|.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|.||..||| | | ..||. .|.|.     ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||..||.| |||.||||
ytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

GSFDH
 .. .
klklt

0051299 (Phosphotyrosine protein) phosphatases II 1636-1924 5.7e-104 342.8 In-house 1-286 (288) alignment
Range on Protein: 1636-1924
Range on HMM: 1-286/288.0
GNTEVPARNLYAYIQKLTqietGENVTGMELEFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI
|.||.....|. ...||.      ..||.. ||..| | ...   . .|.||.|. ||| ..|.||...||.|... |||||||||||.||||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQ
|||||| .|.||||||.||.|....|||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.||||..|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||| | | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||..||.| |.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1370-1640 8.3e-104 342.0 In-house 22-297 (298) alignment
Range on Protein: 1370-1640
Range on HMM: 22-297/298.0
KANDNLKFSQEYESIDPGQQ----FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE
|...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|.....   |||.|| ....|...||.||||. |.||. |||||..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

QRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcNPPD
. ..|.||.|.|||  ..|. .|||..|.||.| ..|.|| . | | . ||.... |. ....|||||..|| |||.||||. |  |..||.|.. .. .
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqq

AG--PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
||  |..|.|||||||.| ||.||..|||.|.|..||..  |  .|..|  .||||.||.||..| |||....|.|.
agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1662-1928 1.5e-101 334.6 In-house 23-287 (319) alignment
Range on Protein: 1662-1928
Range on HMM: 23-287/319.0
TGMELEFKRLASSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
|..| ||| |  ...    | ||. . || |||  ||..|. ||| |... ||||||||||||||||......||||.||..|.||||||.||..| |||
tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPI
||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.| .||.|.||...||... . .|......|..|.  |.|||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPi

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
 ||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||...||.| | | ||.. ..|
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0043336 (Phosphotyrosine protein) phosphatases II 1356-1631 2e-100 331.1 In-house 1-275 (278) alignment
Range on Protein: 1356-1631
Range on HMM: 1-275/278.0
PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
||.. .|......|..|.. ....|.|...  . .|.....|. ||.|||| ....|||||| || ..| ..|||.||.|.|||......||||| ||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPsRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
..|||||.||... |.||.|.|.|..||||.|||| .|..|.| ..||||.. .|..|.|||. . ..|..|.|.|.......||||||||.....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|....... ||..|||||||||||.||... .||....|..||..  |  .| ||  .|||..||.|...||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1636-1931 3.8e-100 330.0 In-house 1-297 (298) alignment
Range on Protein: 1636-1931
Range on HMM: 1-297/298.0
GNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKA--HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA
||||. |..| | .|||....  ...||..|||.|| | .   ..     |. | || |||  .|....|.|| |. . . | ||||||||...|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
.||||.|| ||.||||||..|.... .||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|.|||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
|.  .  .|.. .|.....| | . |. |.|||||||.| || .. ||||.. | |||.||.||.||..||..||||.|| | | | ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0036941 (Phosphotyrosine protein) phosphatases II 1369-1649 6.5e-99 326.2 In-house 7-293 (297) alignment
Range on Protein: 1369-1649
Range on HMM: 7-293/297.0
LKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaiEGiPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR
 |.... ....|.|...| . ........|. |..|||| ....|||.|| |   .. .||||.||.|.|||. ....||||| ||.|..|||||.|||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SATVVMMTKLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVE--LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP
. ..||.|.|.|. |.||.||||.   .. |.| ..||||.. .  |..|..||. ....|..|.|.|..|..| ||||||||.|...|.|...|.....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

P--DAGPMVVHCSAGVGRTGCFIVIDAMLERIK---HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYI
   . ||..|||||||||.|.||..| ||....   .|..|||.  |  .| ||. .|||..||.|...|||| . ...| .|...|. ..
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll

0046845 (Phosphotyrosine protein) phosphatases II 1377-1639 1.6e-98 324.8 In-house 2-280 (284) alignment
Range on Protein: 1377-1639
Range on HMM: 2-280/284.0
FSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYIATQGSLPETFGDFWRMIWEQR
. .|.| .   . .   ......|. |. |||| ....|||||| |. ..| ...|||.||.|.|||     ......||||| ||.|..|||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATVVMMTKLEERSRVKCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--
. ..||.|.|.|..|.||.||||. | . |.| ..||||.. .  .|.|||. | ..| ..| |.|..|..|.|||||||..|...|.||| |.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK---TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE
|. ||.||||||||||||.||..| .||....|.   .||... |  .| ||..||||..||.|...||||.. ...| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

0046845 (Phosphotyrosine protein) phosphatases II 1664-1927 2e-98 324.5 In-house 2-277 (284) alignment
Range on Protein: 1664-1927
Range on HMM: 2-277/284.0
MELEFKRLASSKAHTS-RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDFWRMLWEHN
.| ||..| | . . .  .  |.||.|. ||| ..|.||...||.|... |  |.|||||||..|||     ...|..||||||| .|.||||||.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF
....||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.||||..|..|.||..||| | | ...|. .|..  |..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG---VVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
...||| |||||||||||.||.| ..||....||   .||....||.||.||| ||||..||.| |.|.|||| ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0040438 (Phosphotyrosine protein) phosphatases II 1660-1924 1.4e-97 322.0 In-house 16-276 (317) alignment
Range on Protein: 1660-1924
Range on HMM: 16-276/317.0
NVTGMELEFKRLASSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI
..|... ||..| | | .   .  |.||.|| ||| ..|.||...||.|.|. |...|||||||..||.......||||||| .|.||||||.||...|.
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGP
.||||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..||||..|..|.||..|||.| . ..||. .|..  |  ...||
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggp

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||.| |.|.||||
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0039614 (Phosphotyrosine protein) phosphatases II 1351-1638 2.4e-97 321.2 In-house 8-294 (297) alignment
Range on Protein: 1351-1638
Range on HMM: 8-294/297.0
MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQfTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYIDGYRK-QNAYIAT
. ...|||.  |. .. ..|||.. .. .|.|..   .   .....|..||.|||| ....|||||| |. ..|  ..|||.||.|.|||.. ....|||
llesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTeTHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHP
|| ||||..|||||.|||.. ..||.|||.|..| ||.||||..|. |.| ..||||.. .|. |.|||. . .  ..| |.|..||.| |||||||...
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

TPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT
. .| ||. |....   |. ||..|||||||||||.||... |||....|..||..  |  .| ||...|||..||.|..||||| . ...|
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt

0047943 (Phosphotyrosine protein) phosphatases II 1656-1924 5e-97 319.9 In-house 6-272 (273) alignment
Range on Protein: 1656-1924
Range on HMM: 6-272/273.0
ETGENVTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH
|.  ..|....||..| | |     .  |.||.|| |||  .|.||...||.|    | .||||||||..|||......||||||| .|.||||||.||.
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSTIVVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE
|....||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.||||..|..|.||..||| | | ...|| .|.|. |
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.. ..||. |||||||||||.||.| ..|.....|| ||....||.||.||| ||||..||.| |.|.||||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1363-1633 2.1e-96 317.4 In-house 9-279 (288) alignment
Range on Protein: 1363-1633
Range on HMM: 9-279/288.0
ADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR
 ... . .|...  ||.||.|.   ... . . ..| ||..|||| |...||. || |   |  .|.||.||.||||..|...|||||| |..| .|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
...|... |.||.|.| |. . ||..|||. .. . .| |.|||... ||  . .|.. | |.   ...|. |.|..|||||||||  .|.|..|| ||.
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkv

CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
 |. |.||..||||||||||| ||..||.......|...|. | |. .| ||. .|||. ||.||...||. .
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

0047943 (Phosphotyrosine protein) phosphatases II 1370-1632 3.4e-96 317.2 In-house 7-271 (273) alignment
Range on Protein: 1370-1632
Range on HMM: 7-271/273.0
KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaieGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS
|.... .. .|.| . . . ..|.....|. || |||| ....|||||| |    | .||||.||.|.|||......||||| ||.|..|||||.|||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ATVVMMTKLEERSRVKCDQYWPSRG---TETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP-
 ..||.|.|.|..|.||.||||. |   ..|.| ..||||.. . ..|.|||. |...|..|.|.|..|..| |||||||......| |.. |....   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
 . ||.||||||||||||.||..| .|.....|..||..  | |.| || .||||..||.|...|||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 1351-1633 8.5e-96 316.5 In-house 3-304 (307) alignment
Range on Protein: 1351-1633
Range on HMM: 3-304/307.0
MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYI--------DG
.  ...|..| |  .. .|..... .. .|.|.. . . |   ......|..||.|||| ....|||.|| || ..|  ..|||.||.|.        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKN-GSSEKREVRQFQF
|......||||| ||||. |||||.|||.. ..||.|.|.|. |.||.||||. |.| |.| ..||||.. .|. |.|||. .  . |..| |.|..|..
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TAWPDHGVPEHPTPFLAFLRRVKTCNPP--DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|.|||||||... ..|.|...|....    . ||..|||||||||||.||... ||.....|.|   ||..  | |.|.||  .||...||.|...||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

AV
 .
ll

0039614 (Phosphotyrosine protein) phosphatases II 1654-1927 1.2e-95 315.6 In-house 24-292 (297) alignment
Range on Protein: 1654-1927
Range on HMM: 24-292/297.0
QIETGENVTGMELEFKRLASSKAHtsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRM
..|.  . |...|||..| | |     .  |.||.|| ||| ..|.||...||.|.|..|| ..|||||||..|||.. ....||||||| ||.||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEHNSTIVVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK
.||...|..|||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.||||..||.|.||. ||| | | ...|. .|..  
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
.. ...||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||.| |.|.||.|  .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0045450 (Phosphotyrosine protein) phosphatases II 1647-1924 4.3e-95 314.2 In-house 12-304 (307) alignment
Range on Protein: 1647-1924
Range on HMM: 12-304/307.0
AYIQKLTQIETGENVTGMELEFKRLASSKAH-TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFI--------DGYRQQKAYIA
 .. .| .... ...||.. ||..| | . .    . .|.||.|| ||| ..|.||..|||.|... |  |.|||||||..        |||......||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVP
||||| || |||||||||...|..||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.||||..|..|.||..|||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

KSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||...||.| |.|.||.|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0036941 (Phosphotyrosine protein) phosphatases II 1661-1927 6.4e-95 313.1 In-house 12-280 (297) alignment
Range on Protein: 1661-1927
Range on HMM: 12-280/297.0
VTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
 .... ||..| . ..    .  |.||.|. |||  .|.||..|||.|    . |||||||||..|||......||||||| .|.||||||.||.|.|..
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
||||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.||||..|..|.||. ||| | . ..||| .|.|  ... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPISVHCSAGVGRTGVFITLSIVLERMR---YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
.||. |||||||||.|.||.. ..|....   .|| |||...||.||.||| .|||..||.| |.| ||.| ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0043336 (Phosphotyrosine protein) phosphatases II 1660-1924 8.8e-95 312.6 In-house 18-277 (278) alignment
Range on Protein: 1660-1924
Range on HMM: 18-277/278.0
NVTGMELEFKRLASSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI
. |...|||..| | |     .  |.||.|| ||| ..|.||...||.|... |...|||||||..|||......||||||| ||.||||||.||...|.
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VVMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGP
.||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.||||.......||..||| | . ..||. .|..  |   ..||
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. |||||||||||.||.| ..||....|| ||....||.||.||| .|||..||.| |.|.||||
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 1667-1923 1.7e-94 311.4 In-house 37-294 (330) alignment
Range on Protein: 1667-1923
Range on HMM: 37-294/330.0
EFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL
||. | ... . . .  |.   || |||.|||.||. .|| |....||| ||||||||||||.... .||.|||..|| ||||||.||..|. .||||.|
efnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdgPISV
.|  .|||.|||| | .  |    |    |  . .| .|.| |..     |. .|| |||| || ||. |||  . | .... .|.|...| ..  || |
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivv

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
|||||||||| ||.|. ||||.. |..||.|..|| ||.||| ||||. ||.| |.. |||
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1357-1653 1e-93 308.8 In-house 4-303 (305) alignment
Range on Protein: 1357-1653
Range on HMM: 4-303/305.0
IPILELADHIERLKANDNLKFSQEYESIDPGqQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF
| . .|| .|.  ..... .. ..|.|.    . . .  . |.|| |||..... .|..|. |.. |  . |||.||.|.|||.....||..|| |..| 
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYK-NGSSEKREVRQFQFTAWPDHGVPEHPTPFLA
 ||||.|.| .  |.||.||| |  . || |||| . ||   .| ..|.| .. . . |  | . . . ....|.| | |.|.| |||||||. .| .| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FLRRVKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKL
...||.     | | |..||||||||||| ||..| .|||.|.|..||... .  .| .| .|||| ||| |.|||| | .|||.|..   || | ..||
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

T
 
k

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1353-1646 2.8e-92 304.0 In-house 2-291 (315) alignment
Range on Protein: 1353-1646
Range on HMM: 2-291/315.0
SHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSL
.| |||. .|  .. . ||. .  | |.||||  || .  . ..   || |||| |.||||.||| |  .|  |.|||||||.|||| |.. |||.|| .
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTETHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHPTPFL
... .||||...|.  ...||.|.| |. . |...||| .   ..| . ||. .      |.|||..      .. ||| |...|.||| |||.. .|..
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplm

AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVpARNLY
 . |.||  .  ..|..|||||||||||| || .||.|.... |. .|.|  .| .|..|  |||. .|| ||.|||||.. ||.| . |..||
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdly

DSPc_SM00195 1666-1924 1.4e-91 301.8 In-house 4-262 (263) alignment
Range on Protein: 1666-1924
Range on HMM: 4-262/263.0
LEFKRLASSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||..||.| |.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1666-1924 1.4e-91 301.8 In-house 4-262 (263) alignment
Range on Protein: 1666-1924
Range on HMM: 4-262/263.0
LEFKRLASSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||..||.| |.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

DSPc_SM00195 1377-1633 4.7e-91 300.1 In-house 2-262 (263) alignment
Range on Protein: 1377-1633
Range on HMM: 2-262/263.0
FSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT
...|.|...  . . . .... . || |||| |.. |||.|| |. .|. .||||.|||||.|..|...|||||| ||.|. |||||.||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELA-TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
. ||. . |||.|||.   |.||.| ..|.| .. .    . .||. | |.| .|.|.|.|.|...|||||||......|..|| ||...    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||||||||.|..|| .|.....||.|||   |. .| ||  ||||..||.||..|.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1377-1633 4.7e-91 300.1 In-house 2-262 (263) alignment
Range on Protein: 1377-1633
Range on HMM: 2-262/263.0
FSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT
...|.|...  . . . .... . || |||| |.. |||.|| |. .|. .||||.|||||.|..|...|||||| ||.|. |||||.||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELA-TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
. ||. . |||.|||.   |.||.| ..|.| .. .    . .||. | |.| .|.|.|.|.|...|||||||......|..|| ||...    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||||||||.|..|| .|.....||.|||   |. .| ||  ||||..||.||..|.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0040439 (Phosphotyrosine protein) phosphatases II 1682-1924 8.5e-91 299.2 In-house 4-246 (249) alignment
Range on Protein: 1682-1924
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||...||.|....|...|||||||.||||......||||||| ||.|||||||||...|..||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.||||...|.||||..|||.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|....|. ||....||.||.||| .||...||.| |.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1399-1635 3.6e-90 296.6 In-house 8-244 (250) alignment
Range on Protein: 1399-1635
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVkCDQYWPSRGTETHG
 || |||||..||.|.|||.|   .|   |||.|| ...||....|.||||| |..|. |||||..|. |.|.||.|.|.|  .. . ||||  ..|..|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK
 |.|.||.. | | | .|.. | |.  ...| |||..|..||| ||||. |  |..|..|.. ..  ...|..|.|||||||.|.||.|||.|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
.||..  .  .|..|  .|....||.|.. ..|.|...
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPRB_pd Subfamily PTPRB 1659-1924 1.6e-89 294.8 In-house 22-285 (293) alignment
Range on Protein: 1659-1924
Range on HMM: 22-285/293.0
ENVTGMELEFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
.. ...  |...| . . .     .|.|..|. |||  ||.||. .|| |..... .|||||||..|.||.... .||||||| ||..|||||.||..|.
dsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkss

IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD
|.||||.| | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|.|||..|| ||. |||.. . ..||. .|....|.  ..
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|| |||||||||||.||.|  .|.... | .|||| .|  ||..|  .||||.|| | ... |..|
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1356-1653 2.2e-89 294.9 In-house 15-311 (319) alignment
Range on Protein: 1356-1653
Range on HMM: 15-311/319.0
PIPILELADHIERLKANDNLKFSQEYESI--DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|.  .   . .   .|  |.  |.  .   . .  . ...||. || |||. |..|.|...| |  ..|. .|||.|| ...||.... |||.|| |.
dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPld

ETFGDFWRMIWEQRSATVVMMTkleersRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFL
.|  ||||||||....|.|..|      . || |||| .. ....  .| .    | | | || . | ..|   ..|...|| |  |||.|||..|....
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlm

AFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ
 ....|.  .    .  ..|||||||||||| .||.|..|.|.|.|| ||.|  |  .| ||| .||   || ||. ||||    |...|   .. ||..
rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle

KLT
.|.
els

0040439 (Phosphotyrosine protein) phosphatases II 1391-1633 5.7e-89 293.2 In-house 2-246 (249) alignment
Range on Protein: 1391-1633
Range on HMM: 2-246/249.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP
......|..||.|||| ....|||||| || ..| ..|||.||.|||||. ....||||| ||||..|||||.||... ..||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDA
..|. ..| ..||||.. ... |.|||. |.... .|.|.|...|.| |||||||... ..|.|...|....   |. ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||....|..||..  | |.| ||...||...||.|...|||| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1362-1633 7.3e-89 292.6 In-house 2-276 (281) alignment
Range on Protein: 1362-1633
Range on HMM: 2-276/281.0
LADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
|  |...|..|||  | .|||..   |.. | . |. . |. |||| |..|||..|| ..  |    .||.|||...||.....|||||| .|... .||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRTFALyKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK
.|.|||.  ..||.|.  | ...|| .|||    . . | |.|. . . | |||  |.| | .. |.|.|||.|...|||||||||. .. .| | . |.
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

TCNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
 .. ..   |.|.||||||||||..| .| .......| ...|.   |. .| .||.||||  || |.. |.|.|.
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0042113 (Phosphotyrosine protein) phosphatases II 1393-1631 1.8e-88 291.3 In-house 2-241 (245) alignment
Range on Protein: 1393-1631
Range on HMM: 2-241/245.0
EHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR
....|..||.|||| ....|||.|| || ..| ..|||.||.|.||||  . .||||| ||||..|||||.||... |.||.|..||..||||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP-PDAGPMVVHCSAGVGRTGCFIVIDAMLE
.. |.| ..||||..  |..|.|||. . ..|..|.|||...... |||||||...  .| ||..|...   .. ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
....|..|...  |  .| ||  .|||..||.|...||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 1659-1926 2.4e-88 291.7 In-house 16-289 (563) alignment
Range on Protein: 1659-1926
Range on HMM: 16-289/563.0
ENVTGMELEFKRLASSKAHT-SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS-DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN
.. .|.. ||. | |  ...     ... |.|| ||| .||..|...|| |.|. |.... |||||..||||...||.|||||||..|..|||||.||.|
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT
..|.||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ..|||...|.||..|||..    . |. .  ..
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

KEQfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
...  . ||| |||||||||||..| |. .|.... | .|..|...|..|.||. .||||.||.| . | || . |
nka..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

0045098 (Phosphotyrosine protein) phosphatases II 1379-1636 2e-87 288.4 In-house 12-275 (278) alignment
Range on Protein: 1379-1636
Range on HMM: 12-275/278.0
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLlsaiegipgsDYVNANYIDGYrkQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
. .. . .|.  ........ |..|||| ....||||||           ||.||.|||||  ....||||| ||.|. |||||.||... ..||.|.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN----GSSEKREVRQFQFTAWPDHGVPEHP--TPFLAFLRRVKTCNP---------
|..|.||.||||..|..|.| ..||||.. .| .|..||. ..       . |.|.|...... |||||||..|  ..|| .|.... ..          
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

----PDAGPMVVHCSAGVGRTGCFIVIDAMLERIkhEKTVDIYGHVTLMRAQRNY-MVQTEDQYIFIHDALLEAVTCG
    .. ||..|||||||||||...... |||..  |..||..  |. .| ||.. .||...||.|....||| . .|
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1391-1653 2e-87 288.3 In-house 16-275 (284) alignment
Range on Protein: 1391-1653
Range on HMM: 16-275/284.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTkleersRVKCDQYWP
. ...||. || |||. ...|.|...| |  . |. .|||.|| .| ||.... |||||| |..|  ||||||||....|.|..|      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVID
 .. ....  .| .    | . | || . | ..|   ..|..||| |  |||.|||..|.........|.  .    .  ..|||||||||||| .||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
..|.|.|.|| ||.|  |  .| ||| .||   || ||. ||||    |...|   .. ||...|.
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

Y_phosphatase Protein-tyrosine phosphatase 1400-1631 3e-87 287.3 Pfam-A 1-235 (235) alignment
Range on Protein: 1400-1631
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVLLsaiEGIPG-SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP--SRGTET
|| |||| ....||..|| |   .| .| |||.||||..||......||||| |..|..|||||.|.... ..||.|.|||..|.||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGLVQVTLL-DTV-ELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI
.| ..|.|  ..  . . |..|.. | |.... |||||.|...|.||||||||.|...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|..||..  |  .|.||. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1400-1631 3e-87 287.3 In-house 1-235 (235) alignment
Range on Protein: 1400-1631
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVLLsaiEGIPG-SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP--SRGTET
|| |||| ....||..|| |   .| .| |||.||||..||......||||| |..|..|||||.|.... ..||.|.|||..|.||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGLVQVTLL-DTV-ELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI
.| ..|.|  ..  . . |..|.. | |.... |||||.|...|.||||||||.|...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|..||..  |  .|.||. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0045098 (Phosphotyrosine protein) phosphatases II 1677-1925 4.3e-87 287.3 In-house 21-273 (278) alignment
Range on Protein: 1677-1925
Range on HMM: 21-273/278.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVClqpirgvegsDYINASFIDGYrqQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
. |..  |....|. ||| ..|.||...||.          ||||||.||||  .|..||||||| .|..||||||||...|..||||.| |.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQDGP
||| . | .|  |.|  . |.... |.|| ..||.      |..||.|...... ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ISVHCSAGVGRTGVFITLSIVLERMryEGVVDIFQTVKMLRTQRPA-MVQTEDQYQFSYRAALEYLG
. |||||||||||... . ..||..  ||.||....||.||.|||  .||...||.| |...||.| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1659-1928 6.8e-87 286.4 In-house 19-287 (305) alignment
Range on Protein: 1659-1928
Range on HMM: 19-287/305.0
ENVTGMELEFKRLASSkaHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
.. .|.| ..| |..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .| .||||...|   .
ysdkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

IVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfG
 .||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||| |.|.||||..|||..   ....| .|.|.... .
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.d

QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
.. |. ||||||||||||||...| |||.. |.|||.|. .| ||..|. |||| |||.| . |  |.. ..|
kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_PTPN9_pd Subfamily PTPN9 1649-1924 2.3e-86 284.5 In-house 3-290 (297) alignment
Range on Protein: 1649-1924
Range on HMM: 3-290/297.0
IQKLTQIETGENVTGMELEFKRLASsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
|..| .    ..  |.  |.. . . .. . .|  ..|..|  |||  ... |..||| |. . . | ||||||.|.|||.|.||.||||||| .|..||
ieelvayvkekgkrGlskeyaeirn.epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
|||.||..  ..|| |.. |.|| || ||||   | ||..  . |  .   .. .|  | ..........||.|  |||. ||. |||.|.. ..|.. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
| ... ..            .. || ||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||..||.| | | ||| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

0042113 (Phosphotyrosine protein) phosphatases II 1684-1924 4e-86 283.7 In-house 4-243 (245) alignment
Range on Protein: 1684-1924
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||..|||.|.|. | ..|||||||..||||. . .|||||||.||.|||||||||...|..||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.|.......||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
...|. |.....||.|| ||| .|||..||.| |.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN9_pd Subfamily PTPN9 1371-1631 5.2e-86 283.3 In-house 12-288 (297) alignment
Range on Protein: 1371-1631
Range on HMM: 12-288/297.0
ANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA
....   |.||. |     . | ..|.| .|  ||||..|. ||..|| |. ... . |||.|||..|||....|.|||||.|..|. |||||.|||.  
ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

TVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC------
..||.|...|| |.|| ||||  .  .. .| ..|. ....|   | ||.. ...   .|.|.|  |||..|||.|||.  . .| .|. |.        
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

-------NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
        .|.  |.|||||||.|||| || .|  |.|.... |||.   | |.|.|| ...||..|| | . |.||
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1648-1923 7.7e-86 283.3 In-house 20-291 (319) alignment
Range on Protein: 1648-1923
Range on HMM: 20-291/319.0
YIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
| |. .. .  ...| .| ||.|..   .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .| .|
yqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntlad

FWRMLWEHNSTIVVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
||||.||.|.. .|.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | ..|| |  ||..|||...  .. .. .
fWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE-Y
|.. ...  .  .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||.| | | || .
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Ptp69D_pd Subfamily Ptp69D 1355-1652 1.2e-85 282.4 In-house 2-305 (307) alignment
Range on Protein: 1355-1652
Range on HMM: 2-305/307.0
PPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|.|..|.. ..  | . .  . .|||..     . . . |. . |. |||| ...|.|. || |. |.|   |||.||..| ||.... .|| |. . 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG-----SSEKREVRQFQFTAWPDHGVPEHP
.| |||||||.|| . ..||...|.| .| ||..|||   .  .| . |.| .. .   |  |.. . |..       ..|.| |...|.|.|  |||..
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAY
.  | ....|.  .  . .|.||||||||||.| |. .| .|...| |..|||.  |  .| ||| .||  .||.|.. |||.  . |.|..  ..|   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKL
|..|
ierl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1685-1931 5.9e-85 279.5 In-house 5-249 (250) alignment
Range on Protein: 1685-1931
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|....|.|| |.. .| . ||||||||..||...||.||||||| .|.||||||..|..|. .||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|.|||..|. ||..|||.  .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
. | |||.|. .|.||..|| .|....|| | |...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

Y_phosphatase Protein-tyrosine phosphatase 1689-1922 6.4e-84 276.4 Pfam-A 1-235 (235) alignment
Range on Protein: 1689-1922
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
... |. ||..|.||.||.||| |||...||.| |.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1689-1922 6.4e-84 276.4 In-house 1-235 (235) alignment
Range on Protein: 1689-1922
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
... |. ||..|.||.||.||| |||...||.| |.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Ptp69D_pd Subfamily Ptp69D 1661-1924 8e-84 276.3 In-house 21-286 (307) alignment
Range on Protein: 1661-1924
Range on HMM: 21-286/307.0
VTGMELEFKRLASSKAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
  |.. |...| ... . |    ..   |..|||  .|.....||| |..| | | ||||||||| ||...| .|| |.|. .| .|||||..| ..|..
dfglakeyekLeareidkst.kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFg
|||..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| | |...| |..  ||.. .| ...| ||.. ...  
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

qDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .|| |||||||||.|.|..|...|.... |  ||||.||| || ||. .||  .||.| ||| |.| 
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_PTPN6_pd Subfamily PTPN6 1372-1632 1e-83 275.9 In-house 23-296 (306) alignment
Range on Protein: 1372-1632
Range on HMM: 23-296/306.0
NDNLKFSQEYESI---DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSaIEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQ
 ..  |..|.|..   .  .... ....   || |||| |.. .||.|| |.  ...|||||.|||||..    ....||||||.|..|  |||||.|..
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

RSATVVMMTKLEERSRVKCDQYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC---
 |  .||.||  ||.. || .|||.  . |..| ..|| ..  .||.| .|.. .  |. ..|.|||.|..|..|||||||..|  .|.||. |..    
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

-NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK---TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
 .  .|||.|||||||.|||| |||||..|. |....    .||.  | ..|.||. .||||.|| |.. |. . 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1655-1921 1.3e-83 275.4 In-house 14-276 (288) alignment
Range on Protein: 1655-1921
Range on HMM: 14-276/288.0
IETGENVTGMELEFKRLASSKAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE
.   .| ||.. |.. ||. . . |    ..|. |. |||  ||.||. .|| |.    ..|.||||||.|||....|.|||||||||.| .|||.. .|
kksarnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

HNSTIVVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.... .||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ... |.|.. ||..|||.| . ..... ||. ....
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

FgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL
    ||| |||||||||||.||.|  ...... | ..|.. ||. || ||. .|||. ||.| |.. |
d..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPN6_pd Subfamily PTPN6 1641-1924 1.5e-83 275.3 In-house 5-297 (306) alignment
Range on Protein: 1641-1924
Range on HMM: 5-297/306.0
PARNLYAYIQKLTQIETGENVTGMELEFKRLASS--KAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGY--RQQKAYIA
 |...   ...|.. |.  . .|.| ||..|  .  |   ||   .. | || |||  ||.|.. ||| |.   .| |||||||..|..    ..|.|||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyia

TQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTVRQFQFTDWPEQGVP
||| | .| .|||||.|. ||...||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|.|.|..|..||..|||
tqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

KSGEGFIDFIGQVHKTKEQFG--QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|. . ..||. .|.. .|..   . ||| ||||||.|||| || . |.|. ....|.   .|| ..||..|.||  .||||.||.| |.|  .|.
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_PTPRK_pd Subfamily PTPRK 1688-1922 9.8e-83 272.6 In-house 42-275 (314) alignment
Range on Protein: 1688-1922
Range on HMM: 42-275/314.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSArYQ
 |. |||  .|..|. .|| |..| |   ||||||..||.|.. .|.|.||||| ||..||||.....|.. .||||.| | || || .||| . .  |.
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

YFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFITLSIVLERMR
 . |  .      ... | |.|. .     . |.||||||. ||. .||.| .|..... .|.|..|.  ..|.| |||||| ||||.||...|||. ..
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 |||||.|..|| ||.... ||.||.||.| | ..||
regvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1665-1923 1.8e-82 272.0 In-house 1-255 (284) alignment
Range on Protein: 1665-1923
Range on HMM: 1-255/284.0
ELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT
| ||.|..   . ..    |||. || |||...|.... ..| |... |.|.||||||||| ||.... |||||||| .| .|||||.||.|.. .|.||
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

klremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH
      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |..||| |  ||..|||...  .. .. .|.. ...  .  .| ||
......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE-Y
||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||.| | | || .
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1356-1670 2e-80 265.0 In-house 2-314 (315) alignment
Range on Protein: 1356-1670
Range on HMM: 2-314/315.0
PIPILELADHIErlKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|||. ..   ..  |      ||.|.  .   . .    .  ..| .|||| |.. .|..|| |  |. .| |||.|| || .. ...||||.|| |. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFaLYKNgSSEKREVRQFQFTAWPDHGVPEHPTPFLA
  |||||..... .|.||.||..|  ..|| |||| | ..    | ..|.||..   .   .| .   .. | |.| | ||||| |||.||... . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk.seesrtvtqfqftewPdkGvdkqtssllk

FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
... ||. | ..  ...||||||||||| .| || ....||....||..  |. .||.| |.||||..| ||.||.|| .   || ..  ..  ..| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QIETGENVTGMELEFKR
    |.  . |  ||..
tsvdgsgrskmtkefet

subfamily_PTPN12_pd Subfamily PTPN12 1680-1924 6.4e-80 263.1 In-house 31-277 (290) alignment
Range on Protein: 1680-1924
Range on HMM: 31-277/290.0
RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP
.  ... . |. |||  .|.||. .|| |. |...||||||||.|| |  ....|||.||||..| .|||||.||.| .||||. .. |.|. ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

AE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
 |  .. ... | |. ..| ..  ....| .||.    ..||.|.||..|.||..|||.| .  ...| .|....|   .| |. |||||||||||. |.
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. .| | .. | .   .|.|. |  ||.||.|.|||..||.. |.| .|..
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1659-1930 8.1e-80 262.8 In-house 17-289 (290) alignment
Range on Protein: 1659-1930
Range on HMM: 17-289/290.0
ENVTGMELEFKRLASSKAHTSrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN
.. .|.. .||.| |.. . .    .. . || .||  ||..|.  |. |.|| | .    .||||..|.||...|.|||||||. .|  |||...|...
kgnegfrnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG
.||.||||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |....| |.|.| |...|  .  .. .  | .. ||. . |
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

qDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
 ...| ||||..|||..||... . ..... |||.|.|| .| .|.|.| .|||..|||. ..  |.|| ||. |
.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1375-1673 1.7e-79 262.3 In-house 18-316 (515) alignment
Range on Protein: 1375-1673
Range on HMM: 18-316/515.0
LKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
  ||.|.  .   . .    .. |.| .|||| |.. || .|| |  |.  | |||.|| || ..  ..||||.|| .. .  ||||...... .|..|.
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
|||.|  ..|| .||| . ..    | ..| |. .   .    |.. . |.     | | ||.|| |||.|||.| . .| ... ||. .   . |...|
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA
||||||||| .| || .. ..|  ..||..  || .|..| |.|||..|| ||..|.|| .   || .|   .  ..| |     |.  . |  ||. | 
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

S
|
s

0037934 (Phosphotyrosine protein) phosphatases II 1392-1631 4.3e-79 260.7 In-house 2-240 (243) alignment
Range on Protein: 1392-1631
Range on HMM: 2-240/243.0
WEHSNLEVNKPKNRYANVIAYDHSRVLLsaiegiPGSDYVNANYIDGYRKqnaYIATQGSLPETFGD----FWRMIWEQRSATVVMMTKLEERSRVKCDQ
. ...|..|..|||| ....|||||| |      .||||.|||.|.....   .||||| ||||. |    ||||.||... ..||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsrGTETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--------NPPDAGPMVVHCSAGVG
|||  |..|.| ..||||.. .|. |.|||. |.  . . ..|.|.......|||||||..|...|.||. |...        . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERIkhekTVDIYGHVTLMRAQRNY-MVQTEDQYIFIHDALLE
|||..|... ||...    .||..  | |.|.||.. .|||..||.|...||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1357-1655 1.2e-77 256.2 In-house 5-310 (325) alignment
Range on Protein: 1357-1655
Range on HMM: 5-310/325.0
IPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF
| ...| .|.|. ||.|.  |..|.. . . .  . . . .  || |||. ||.|.|.||| | . .  | |||.||.|.  ..|.. ..|.|  |..| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMIWEQRSATVVMMTKLeERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF
.|.||.. . |.. ||.. .| .    .| .||| .   . | | ..| |    |.. |  | . . .    | | |.|||. .|.| ||...|. ....
ndlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKT------CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAY
|. ||.      .|   ..|..||||||||||| || . ..|... .|  |||.| |  .|..|  ||.| ||||.|..|| ||. .|||.||  .. | 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLTQI
.  | . 
lsslqer

0037934 (Phosphotyrosine protein) phosphatases II 1683-1924 1.9e-77 255.4 In-house 4-242 (243) alignment
Range on Protein: 1683-1924
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYESTRVCLqpirgvEGSDYINASFIDGYRQqkaYIATQGPLAETTED----FWRMLWEHNSTIVVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||..|.....   .||||||| ||.||    |||||||...|..||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQDGPISVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|.|...... ||..||| | | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDIFQTVKMLRTQRPA-MVQTEDQYQFSYRAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||..||.| |.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1398-1632 2.6e-77 254.2 In-house 5-239 (239) alignment
Range on Protein: 1398-1632
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTET
 ||| ||||||...||||||.|  .   | |||.||.|.  |    .|||||||..  . ||||||.|..| . .||.| | |  . || ||||   |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsk

HGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHE
.  ..|||  |  .| | .||| . . | .|.| | |..|| |||.|||.. |  | . |..   . | | | |.||||||||||.|.|||||| . |..
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
|||||. .|  .| .| .|||| .||.||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1653-1924 2.6e-77 254.7 In-house 6-276 (281) alignment
Range on Protein: 1653-1924
Range on HMM: 6-276/281.0
TQIETGENVTGMELEFKRLASSK-AHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM
.. .. .. .|.  |.. ||.    .|..  ... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .. ..||.|
lkqlsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

LWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT
.||.. ...||.|.  | |. |||.||| .. . .|  ..|  .|| . ..|| |.||. ....|..|.|.|...| ||..|||.. . ...|  .|.|.
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

KEQFGQdGPISVHCSAGVGRTGVFITLSIVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|.  .  |. .||||||||||..|.|  .....   .  .|. ..|. || .|  ||||  ||.| |.| |..|
tekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_PTPN12_pd Subfamily PTPN12 1388-1633 2.9e-77 254.4 In-house 28-277 (290) alignment
Range on Protein: 1388-1633
Range on HMM: 28-277/290.0
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
.... |... |.|. |||| ... ||.||| || ||. .||||.|||.| |  .. .|||.|| ||.|  ||||||||..   |||. .. |  . ||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPSRGTETH--GLVQVTLLDTVELA-TYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI
|||..| |.   | ..||| .   .   . .||... ..  .|.|.|.||..|||||||||. ... |.... |.. .  .. |.||||||||||||  |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
.|| . | .|.||.   .|..  |. .| ||. .|||..|| ... |..| |
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1397-1631 6.9e-77 252.8 In-house 5-239 (239) alignment
Range on Protein: 1397-1631
Range on HMM: 5-239/239.0
LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTE
  ||| ||||||...||||||.|  .   | |||.||.|.  |    .|||||||..  . ||||||.|..| . .||.| | |  . || ||||   | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH
 .  ..|||  |  .| | .||| . . | .|.| | |..|| |||.|||.. |  | . |..   . | | | |.||||||||||.|.|||||| . |.
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
.|||||. .|  .| .| .|||| .||.||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1357-1637 5.8e-75 246.8 In-house 2-287 (290) alignment
Range on Protein: 1357-1637
Range on HMM: 2-287/290.0
IPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAYIATQGSLP
||. .......  .|. | .| ......| |. ..| .. . . ||..||.||.. ||  |. |  | | .    .|.|| ||.||.....|||||| ..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHG-VPEHPTPF
.|  |||..||..... .||.|.  |  .||| ||||...|.. | ....||.  .| .|  |.. . .. |  .|..| |.|.|.|...| |... |  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
|.. ...||   .  ...|||||..|||.. |....  ... | |  .|..  .  .| |.  .|||..|| .|.. .|..... .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_PTPN13_pd Subfamily PTPN13 1391-1634 1.5e-74 245.7 In-house 28-270 (273) alignment
Range on Protein: 1391-1634
Range on HMM: 28-270/273.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsdYVNANYIDGYRKQ--NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQY
| | .. . || |||| ||. ||..|| |..  |     |.||..|     .    |||.|| ||||  |||.|.|||..  ..|.|.  |. .|||..|
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPSRGTETH---GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPpDAGPMVVHCSAGVGRTGCFIV
||..  ..    . ..|.||....| .. ||..|. .. |.| ||| ...|..||||||| .....| |...|.. .  ||||.|||||||.||.| .|.
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
||..|. |...| .|.   |  .| ||. .|||.|||||.. |.||...
idvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1355-1643 3.7e-74 244.5 In-house 8-294 (297) alignment
Range on Protein: 1355-1643
Range on HMM: 8-294/297.0
PPIPILELADHIERLKANDnlKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKqnAYIATQGSLPE
 |||. ..|  ... .  |   ||.|.  .   . ..   ..  || .|.||.|.. || ||| |  ..  | |||||| .. |...   .|.||   ..
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPE--HPTPFL
|  |||.|..... .|.||.....|| . || .||. .|. | | | |.|| . |   .  |.. . |. .  .| |.|.||. |||. |..  . . .|
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

AFLRRVKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR
 ..  |.      |  |..|||.||||||| .. || .. ..|.||.|||.| |. .| .| |.|||..|| |.. |.|||. . .|...| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1688-1924 1.9e-73 242.3 In-house 42-276 (515) alignment
Range on Protein: 1688-1924
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||.|.|| |. |     |||.|||.| ..  .|||||.|||.  ...||||.....| | ..|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||| ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
   .||.|..|. .| .|| .|||..|| | | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_PTPN3_pd Subfamily PTPN3 1391-1633 2e-73 241.8 In-house 32-275 (280) alignment
Range on Protein: 1391-1633
Range on HMM: 32-275/280.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYID----GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD
. .....  | .|||| ....||. || |.. |     ||.||||..    .    | |||||| |..|  |||.|.|||.| ..||.| | || |||| 
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV
||||. .   ..|  .|..  . |  .|..| . | .. ..|.|.. |.|..||||||||.... || |..||...   .  |.|||||||.|||| .|.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
..  |  | ... | .   |  || ||  .|||..|| |. .|.|.. 
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1658-1931 3.4e-73 241.1 In-house 16-285 (287) alignment
Range on Protein: 1658-1931
Range on HMM: 16-285/287.0
GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNS
 .. .| .  |. | . . .      .  . || |||| .|....  || |.     |  |||||.|||||...||.|....|...|  .||......| 
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

TIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGq
|..|||....|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ..|.|.|.|.|...|  .. .  .  | .  ||. . | 
taivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.

DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
...| ||||..|||...|.   . ... . |||.|.|| .|  | |.| .||| .||.| . . |||| ||. |.
ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1361-1640 5.7e-73 240.8 In-house 6-286 (439) alignment
Range on Protein: 1361-1640
Range on HMM: 6-286/439.0
ELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG
|. .|.|.|. |..  |....|.|.   |  .        | ...|||| .| |.||.|| |  | |.| | |.|||||.|| ... ||||||   ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEQRSATVVMMTKLEERSRvkcdqYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS--SEKREVRQFQFTAWPDHGVPEHPTPFLAFL
||||...|....|.||.|.| |  .     |||| .   .| . |     .||  |..| | ....      .| | ||...||||. || . .  | ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||| | |...| ||. |||.  ||.||..|.|| .  |.. |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1390-1631 6.3e-73 240.2 In-house 18-266 (274) alignment
Range on Protein: 1390-1631
Range on HMM: 18-266/274.0
FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
|. |. ..  .. |||| ...  ..|||||.. ..  . |.|.||||| ||.. ..||.|||| ||.|  ||||||.....  .||.|||.|. . || .
fdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPSRG----TETHGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP---PDAGPMVVHCSAGVGRT
|.| .     .|..| |...  ..||   | ||.. | .  .  .|.|  . .|.|||| .|......| ... |.. .      ..|.|||||||.|||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|||| |.  . ....|..||. . |. .| .|  ||||..|| .|| || .
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_PTPN3_pd Subfamily PTPN3 1667-1919 2.9e-72 237.9 In-house 20-270 (280) alignment
Range on Protein: 1667-1919
Range on HMM: 20-270/280.0
EFKRLASsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirGVEGsDYINASFI----DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM
.|..|   |        |..| |  |||  .|.||..||| |.     |  |||||...    ..  . . |||||||||.|..|||.|.||..|...||
qfeqlyr.kkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
|| | | || ||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.. |.|...||..|||.. . |..|. .|.|...  |.. |. 
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRA
||||||.|||||.|.| . |  .  .  | . . |...| || ..|||..||.|   |
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1685-1925 9.8e-72 236.3 In-house 24-269 (274) alignment
Range on Protein: 1685-1925
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .| ||.. .|||.||||||..| .|||||.........||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD-GPISVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|.|  . .||||.. .|.. . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLG
|| . ..| |.|||....|  || .|  ||||..||.. .||  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1357-1640 1.4e-70 232.5 In-house 2-285 (287) alignment
Range on Protein: 1357-1640
Range on HMM: 2-285/287.0
IPILELADHIERLKANDNLKFSQEYESIDP-GQQF-TWEHSNLEVNKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQNAYIATQGSLPE
||. .... ... .|. |  |.. .  ..  .|.     |.  . ||.|||..... .|  ||||         ||.|| .||||....|.|.... . .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHG-VPEHPTPFL
|  .||..|....  ..||.....|  . .| ||||.  . . |  ...||.    | | .|.. . ... ...|..|.|.|.|.|...| |.|. | .|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
 . ...||   .  ...|||||..|||.. |. ..  ... | | ..|..  .  .| |.  .||| .||.|| |..|| .....| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1679-1924 3.1e-70 231.5 In-house 34-277 (315) alignment
Range on Protein: 1679-1924
Range on HMM: 34-277/315.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYW
.|  .|  . |  |||  ||.|..|.|| |. |     |||||||.| .. ..|||||.||||  . .|||||..... | .||.||..|  . || |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFIT
|     |...  . |. .      . . |.. ||  .  .|||| |||||.||..||.|    .. .| .|   ...  .. .. ||||||||||||.|.
PdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.  |..... . .||.|..||.||..|| .||||..| | | | ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1674-1928 3.9e-70 231.3 In-house 36-288 (297) alignment
Range on Protein: 1674-1928
Range on HMM: 36-288/297.0
SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQqkAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGReK
 .| .     |.   |  |.|  ||.||.| || |. .     |||.||||. |...   .|.|| |  .| .|||.|..... ...|||... |  . |
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.k

CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK--SGEGFIDFIGQVHKTKEQFGQDgPISVHCSAGVGRT
| .||. . .. . . .|  ..  .   .| ||..||  .  . | |.|.||..||.. |..  | . ....| .|.|. .|  .  |. |||.||||||
caryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrt

GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
||..|.  |. ... |  ||||..||.|| .|| .|||..||.| | | ||.| | |
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1400-1631 6.1e-69 226.8 In-house 3-237 (237) alignment
Range on Protein: 1400-1631
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVLLSAIEGipGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG-TETH
|| ||||.|..|||||||.|    .  ||||.||.|..|.    . |||.|| |  .  |||.|.|... . .||.| | |. ..|| .||||    ...
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIK
| . |.|    |.. | ||.. | |...  | | . |.|||.|||.|||.. . .| | ...   .|  ...|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
 .| |||| .|  .  .| |..||.|||.|||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN13_pd Subfamily PTPN13 1667-1926 1.2e-68 226.4 In-house 16-271 (273) alignment
Range on Protein: 1667-1926
Range on HMM: 16-271/273.0
EFKRLASSKAHTSRFiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSdYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT
||| |   |.  .   ...   || |||  |..||. ||| |.     ||. |||||.|      ..  |||.|||| ||..|||.|.|| ......|.|
efkelrelkpldtce.vgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPIS
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| | ...|..||. |||.| . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|. || || ..|||.||| | |.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_PTPN14_pd Subfamily PTPN14 1666-1924 6e-68 224.0 In-house 27-296 (300) alignment
Range on Protein: 1666-1924
Range on HMM: 27-296/300.0
LEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVeGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
 |. |..  ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| |      ... ||..||||  | .|||.|.||.. ...|||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TKLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
|. .| |.||...|.| .    ...... | |      . ...| . .|.     .. |||  .|.||||..|||.  .||.... .|.  .... .   
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
    . |. |||||||||||| |.  .... .  . ..|| .....||.||  .|||  ||.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1662-1925 1.2e-67 223.4 In-house 23-289 (325) alignment
Range on Protein: 1662-1925
Range on HMM: 23-289/325.0
TGMELEFKRLASSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
 |.  ||. | |  . .  .  | .| || |||. |..... .||.|.  .    |||||||..  ..... ..|.| ||..|..|.||.. . ....||
dgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv

MLTKLrEMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
.| .| . | ..| .||| |   | ..  . |  ..  ..  |. | ..| ....|..|.|.|||.  |.. ||.|    .| ..  |.. .|.      
vlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLG
  .|| ||||||||||||||.|  .|...  |  ||||. || || .||.||.| ||| . | |  |.. 
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym

subfamily_PTPN1_pd Subfamily PTPN1 1383-1635 3.4e-67 221.2 In-house 14-273 (290) alignment
Range on Protein: 1383-1635
Range on HMM: 14-273/290.0
SIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERS
 |.   ..|. ....|. |...||| .|  |||||. |   .     ||.||. ..  . .  || ||| ||.| . ||.|.|||.| .|||. |. |..
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

RVKCDQYWPSRGTE-----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT--CNPPDAGPMVVHCS
..|| ||||.   |      .  ..|.|. . .  .| ||.. | .  . | ||. .| .|.||| |||| |. || || .|.   .  .| || |.|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
||.||.| |...|..| .|....    |||  ..  .| .|  ..|| ||  | . |.|| . .
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1687-1924 5.4e-67 220.6 In-house 18-264 (270) alignment
Range on Protein: 1687-1924
Range on HMM: 18-264/270.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-
  .|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. |...||||.||...| .||.|.| | ||.|| .|||||.   
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-RYQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFI
 ....    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . .|. |||||||||||..|
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.| |... .  .. ||. . .. || .|.|.||. .||.| |.| .|| 
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPN23_pd Subfamily PTPN23 1657-1923 8.7e-67 219.9 In-house 10-279 (288) alignment
Range on Protein: 1657-1923
Range on HMM: 10-279/288.0
TGENVTGMELEFKRLASSKAHTSRFISAN-LPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQ-KAYIATQGPLAETTEDFWRMLWE
. ...|... .|| | ..... .|  |     ..  |||  .|.||...||.|.     .  |||||||. .   .   .||||.||..|  |||.|..|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

HNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK--T
  | ..|||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ..|.  |.| ||| |||.| | ...|...|..  .
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

KEQFGQDGPISVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
..|   . |. |||||||||||||    ..| |  . .|..|| | |. ||.||  |||...|..||| | ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1684-1924 1.7e-66 219.3 In-house 44-279 (315) alignment
Range on Protein: 1684-1924
Range on HMM: 44-279/315.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAErS
|.   || ||| .||..|. .|| |  .   ..|||.||.||||| ... |||.|||.... .||||...|.. . .||||.| |  ..|. .||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

ARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLER
  |  . |  . |    .|  | . |.   . . |.| |...| ||. ||||.   ....| .|.. ...    |.| ||||||||||| ||||. ||..
viyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.  | ..|... .. .| .|  |||. .|||| | | || .
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_CG7180_pd Subfamily CG7180 1689-1924 2.3e-65 215.2 In-house 42-290 (296) alignment
Range on Protein: 1689-1924
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||...|.. ..|.|| |..|  || ..|||.......  ||.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQDGPISVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |.|..||.| |.  . || | ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
... . || .. |. ||.|. ||.|| .|| .|.. ..|.. |   ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1356-1678 6.2e-65 214.1 In-house 3-281 (392) alignment
Range on Protein: 1356-1678
Range on HMM: 3-281/392.0
PIPILELADHIERLKanDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|||. ..   .|. .   .  |..|.  .   . .    .. |.|..|||| |.. || .|| |  |. || |||.|| ||...  ..||||.||  . .
pipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FGDFWRMIWEQRSATVVMMTKLEERSrvkcdqywpsrgtethglvqvtlldtvelatycvrtfalyknGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
. |||||..... .|..|.|||.|                                               ..| | ||.|| |||..||.| . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI
. ||.     . |...||||||||||  | ||... . |. . ||..  || .| .| |||||..|| ||. |.|| .   || .|   .  ..|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

ETGENVTGMELEFKRLASSKAHT
  |.  . .  ||. | .|.. |
sdGdvrskqlkefrslkashtvt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1372-1647 2.7e-63 208.5 In-house 6-280 (283) alignment
Range on Protein: 1372-1647
Range on HMM: 6-280/283.0
NDNLKFSQEYESIDPGQQFTWEHSnLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYID---GYRKQNAYIATQGSLPETFGDFWRMIWEQRS
|.|  | . .. .   .. .  .|  . ||.|||. .....|  || | .       ||.|| .|     |.... ||..|. | .|  |||.|..... 
nnnklfrevlkrlsvpdldadias.adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKR-EVRQFQFTAWPDHGvPEHPTPFLAFLRRVKTCNP-PDA
...||.||| |  |.|| ||||.||.| .|   ||| . .   .. .. . | .|.|...   .  .|.  | . | .. .   |  . .|..       
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskk

GPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA
||.|||||.|.|||. || . | .. .. |  ||..  |. || ||  .||| ||| ..|.. ||   ||.|.. | .|..
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs

subfamily_PTPRN_pd Subfamily PTPRN 1660-1922 7.5e-63 207.0 In-house 27-290 (297) alignment
Range on Protein: 1660-1922
Range on HMM: 27-290/297.0
NVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI-DGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
| . .| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.| |   .. ||||||||||.|  |||.|.||. ..
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQD
..|.||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||| || |  |||.||| |   ...|  .| |.    |. 
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grs

GPISVHCSAGVGRTGVFITLSIVLERMRyEG--VVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 || ||||.|.|||||.| . .||.|.   |   .||  |.. || ||| .|.|.||..| . |  |
cpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1660-1930 7.5e-63 207.0 In-house 13-299 (301) alignment
Range on Protein: 1660-1930
Range on HMM: 13-299/301.0
NVTGMELEFKRLASSKAHTSRfISANlPCNKFKNRLVNIMPYESTRVCLQPIRG--VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNS
. ...| ..|.| . . ...  .. .   ||  ||  || .|.  |. |.| .   .   .|||||.||||...|..||.|||. .|  ||||..|..  
hsnkfeeqykelkegedksct.vgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TIVVMLTKLREMGREKCHQYWPAERSARY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTVRQFQFTDWPEQGVPKSGEGF
. .||.|.|.|  ..||.||||  .  ..    | |  . |...|....|...|.  |              .| .|..| |.| ||||..|| .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

IDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
.  | .| ... . |  ||. ||||..|.|.||....|| ||  . |||||.|| .| .| ..| .|.| .|| . | .  .||   . |
Lqviddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_CG7180_pd Subfamily CG7180 1397-1637 1.2e-62 206.2 In-house 39-294 (296) alignment
Range on Protein: 1397-1637
Range on HMM: 39-294/296.0
LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTET
 . |. |||. .|. ||. ||.|. ..|   |||.|| |.|.. |...|| |..   || ..|||..... . .||..||  . .. .. .||| .. | 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

HGLVQVTLLDTVELATYCVRTFALYKN----------GSSEKREVRQFQFTAWPD-HGVPEHPTPFLAFLRRVKTC-----NPPDAGPMVVHCSAGVGRT
.| . | .. . ..|    ||| |.|.           . |.| |..||.| |.  . ||   . .. ..|||..      . |. ||.||..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
| .. ||| || ...|. ||... |  .| .|. .|.. ..| .| | ||||| |. 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_PTPRN_pd Subfamily PTPRN 1378-1633 4.3e-62 204.5 In-house 32-292 (297) alignment
Range on Protein: 1378-1633
Range on HMM: 32-292/297.0
SQEYESIDP--GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI-DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
..|.|..     .. | | .. | |  |||...|..|||||| |..      |||.||  | |   .. ||||||| |..|  |||.|.||| .. .|..
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

TKLEERSRVKCDQYWPSRGTETHGLVQVTLLD-TVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC
|.||| .  .|..|||  |.|.... .| |.   .    | ||.| |    .|| | | || | .||..|||  . ..| | |.|  .    . |.||||
trleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

SAGVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|.|.||||..|.|| .|.|. |  | .||   .  .| ||. .|.|.||. |.  |. | |
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1399-1631 2.1e-61 202.3 In-house 19-262 (270) alignment
Range on Protein: 1399-1631
Range on HMM: 19-262/270.0
VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ-NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--
 .|  ||||...   ..|| |. .|  . . |.||||. |. .. ..|||..| || |  .|||||||... ..||.|.|||. | ||..|||..  |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--THGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPT------PFLAFLRRV-KTCNPPD-AGPMVVHCSAGVGRTGCFIV
  ..| ..|. | ..    | ..   | ..|.  .|..  |....|||||||...         |. || | ....  | |.|..|||||||||||..|.
kledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
.| ... ....| ||.   .. .| .|  .||. .|| |.. |..|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1387-1630 2.6e-61 201.9 In-house 25-274 (287) alignment
Range on Protein: 1387-1630
Range on HMM: 25-274/287.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAiEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD
.  .|.  ..   .  |||||.|. .|..|||||| ||  ||||.||||. .|....|.||.|| .. | .||||...|.|||.|..||.  | .| || 
sstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPSRGTET-HGLVQVTLLDTVE-LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV-----KTCNPPDAGPMVVHCSAGVGR
.||| |      |   |.|||       |.||.. | .  . | | |.|... .|||....     .. |   |      . .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
.| .. . ....| .    ||.   |  .| .|. .||.  |. .. .|| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1689-1924 2.8e-61 202.3 In-house 48-279 (439) alignment
Range on Protein: 1689-1924
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| .|.|| ..| |||||||  |||.||||...|.... .||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||| ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|  |||   ||.|| ||  |||.  || | | | || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1664-1923 7e-61 200.5 In-house 12-276 (287) alignment
Range on Protein: 1664-1923
Range on HMM: 12-276/287.0
MELEFKRLA-SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM
.. |...|   |.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| |  ||||...|..|. |..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LTKLREMGREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV--HK-TKEQFGQD
.|.  | .| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| |.|... .||..... .  |.| |. .|  |   . .  . 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
||. ||...|.||.|..... ....|.   | ||. ..|  || .| |.||.  |....| |   |
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_PTPN23_pd Subfamily PTPN23 1398-1633 2.1e-60 199.0 In-house 41-280 (288) alignment
Range on Protein: 1398-1633
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQ-NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG--T
...  |||. ... |||.|| |         ||.|| .. .   .   .||||. |..| .|||.|..||.| ..||... ||. . |.|.|||..   |
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC----NPPDAGPMVVHCSAGVGRTGCFIVIDAML
...| ..||| .. |. |.  |.. |  ........|.  |.|.||..|||. |  .|.||  |...    . .   |.|||||||||||| | .. | .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ERIK-HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
. .. ..  .||   |  .|.|| .|||...|. |  .| |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1684-1923 2.4e-60 198.8 In-house 28-265 (283) alignment
Range on Protein: 1684-1923
Range on HMM: 28-265/283.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFID---GYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA
|    || |||  .|.|..  || |..       |||||.||     |.|.| ||..|.|| .|  |||.|..... | .||||||.|  |.|| |||| 
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQDGPISVHCSAGVGRTGVFITLSI
. |  |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..| 
rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasa

VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
 .. .. | |||.|..||..| ||. .||| |||.. . ..|| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_PTPN1_pd Subfamily PTPN1 1676-1922 3.6e-60 198.1 In-house 19-269 (290) alignment
Range on Protein: 1676-1922
Range on HMM: 19-269/290.0
AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH
|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||..|.. ||.|.||..|  |||| |. | .. ||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR
|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.. .| .| ||. |||.|   |..|. .| ..     . ||  .|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.| |. .  .| ..  ..    ||| ...  || .|  ..|| || .||| | ||
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN14_pd Subfamily PTPN14 1377-1632 4.3e-60 198.2 In-house 25-295 (300) alignment
Range on Protein: 1377-1632
Range on HMM: 25-295/300.0
FSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIpGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM
  .||| | . ..  . . ..|..|..|||. .|. |...|| ||. .    ..|.||  |      |.  ||..|| |. |  |||.|.|||  . .||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

MTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN-------
.|. ||  . |. .|.|. .    | ..|  .||   . .  ..  ... |.   |.|.|.|  .|.| |||||||| ...|| .|..|.          
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

P--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
.      |..|||||||||||  |. | ... ..|....||   .. .| || ..|||  || |....|.. 
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

0051429 (Phosphotyrosine protein) phosphatases II 1425-1653 1.7e-57 190.4 In-house 1-244 (272) alignment
Range on Protein: 1425-1653
Range on HMM: 1-244/272.0
IPGSDYVNANYIDGYRK---QNAYIATQGSLPETFGDFWRMiWEQRSATVVMMTKLEERSRVKCDQYWP------------SRGTETHGLVQVTLLDTVE
.| |.|.||....|| .    .......| || |  ||||. .|..  |.|.....||| |.|||.|||            |  | ..| . |||| .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LATYCVRTFALYKN-GSSEKREVRQFQFTAWPDHGVPEHPtpFLAFLRRVKTcnppdAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVD--------
|  | .|.. |..  . .| |||.....|.|||||||...  .|..|. . .      ||..||||||..|||...... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAvTCGNTEVPARNLYAYIQKLT
... |  .|||| ..||||.||.|...||||.  .. ..|.|. | |... . 
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1372-1639 1.9e-57 189.3 In-house 12-299 (301) alignment
Range on Protein: 1372-1639
Range on HMM: 12-299/301.0
NDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEG--IPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA
. . ||...|.... |.. . . .  | ||. ||. |.  ||. |..|.  .   .   .|.||.|||||......||.|| . .|  ||||.||... .
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TVVMMTKLEERSRVKCDQYWPSRG--TETHGLVQVTLLDTVELATYCVRTFAL-YKNGSS--------------EKREVRQFQFTAWPDHGV-PEHPTPF
..||.|.|.|... || ||||.    .|. | ..||| ..  .  . .| ...  ..||.              . ..| |.| | ||..|| .|. |  
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE
 .    ... . .. ||.|||||..|.|.| .. ..  ||  | |  ||... .  .| ..  .|.| .||..|.|.. . ... .|.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

0051429 (Phosphotyrosine protein) phosphatases II 1715-1926 4.1e-57 189.1 In-house 2-227 (272) alignment
Range on Protein: 1715-1926
Range on HMM: 2-227/272.0
EGSDYINASFIDGYRQ---QKAYIATQGPLAETTEDFWRMlWEHNSTIVVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  | .||||. .|.. . .|.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPKSGegFIDFIGQVHKtkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.|.....||||  |||..   ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
 ....|..|| |||..||||.||.| |.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1683-1924 1.3e-56 186.7 In-house 39-236 (392) alignment
Range on Protein: 1683-1924
Range on HMM: 39-236/392.0
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGrekchqywpaer
.|. . |. |||  ||.||.|.|| |. |  .  |||.|||.|... ..|||||.||| | . .|||||....| | ..|.|||.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

saryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktKEQFGQDG-PISVHCSAGVGRTGVFITLSIVL
                              .  . ||| ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |.
..............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvv

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 . .   .||.|. |  .| .|| ||||..|| | | | || |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1689-1922 1.8e-56 186.0 In-house 3-237 (237) alignment
Range on Protein: 1689-1922
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYESTRVCLQPIRGveGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||....|.    | |||.||||  . .|||.|.|. . ...|||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | . |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 . ||||.. |. .  .|| ..||.||| | ... ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1688-1922 6.1e-56 184.2 In-house 6-238 (239) alignment
Range on Protein: 1688-1922
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|.    ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.  ||||. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1688-1922 8.1e-56 183.8 In-house 7-239 (239) alignment
Range on Protein: 1688-1922
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|.    ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.  ||||. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

0041856 (Phosphotyrosine protein) phosphatases II 1400-1640 4.1e-55 181.5 In-house 1-178 (182) alignment
Range on Protein: 1400-1640
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRvllsaiegipGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTkleersrvkCDQYWPsrgtethgl
|..|||| ... |||||          ..||.|||...|..... .||||| |..|. ||.||..|..  |.|..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

vqvtlldtvelatycvrtfalykngSSEKREVRQFQFTAWPDHGVPEhPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVIDAMLERikhekTV
                         . ..|.. |.... |||||||. .  .|.|...|.     . || .|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
...  | |.| .|. ||.|..||.|...|||| . ...|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp

0041856 (Phosphotyrosine protein) phosphatases II 1689-1924 5.6e-53 174.5 In-house 1-171 (182) alignment
Range on Protein: 1689-1924
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYESTRvclqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| .|..||.|||.|.. |..|.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTVRQFQFTDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 |.....||..| .|| ||.|..||.| ..|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell

0036282 (Phosphotyrosine protein) phosphatases II 1716-1915 4.2e-52 171.6 In-house 1-161 (174) alignment
Range on Protein: 1716-1915
Range on HMM: 1-161/174.0
GSDYINASFIDGYRQQKAYIATQGPLAettedFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||..|...  . .||.|||||     ||.||.|...|.||||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTVRQFQFTDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRyEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..||....|..||.||| ||||..||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf





0036282 (Phosphotyrosine protein) phosphatases II 1427-1627 1.4e-51 169.9 In-house 1-164 (174) alignment
Range on Protein: 1427-1627
Range on HMM: 1-164/174.0
GSDYVNANYIDGYRKQNAYIATQGSLPetfgdFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSrgtethglvqvtlldtvelatycvrtfalykNGSS
|||| ||...|...  . .||.|| |.     ||.|..|... ||||.....|. ..|| .|||.                               . ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKREVRQFQFTAWPDHGVPEHPTpFLAFLRRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKhEKTVDIYGHVTLMRAQRNYMVQTEDQYIFI
..|.. |.... |||||||. .. .| |...|...    . ||..|||||||||||...... || ... |..||.. .|  .| || .||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy

0049772 (Phosphotyrosine protein) phosphatases II 1654-1924 3.7e-48 160.2 In-house 11-280 (314) alignment
Range on Protein: 1654-1924
Range on HMM: 11-280/314.0
QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYEsTRVCLqPIRGVEGSDYINASFIDGYrqqKAYIATQGPLAETTEDF-----
.. . .......|...|.  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .| .||     
ellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepv

-----WRML--WEHNSTIVVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTV
     |||   ...|. ..||                     |..| . |      ...|.. . ..                    .... ..  .|..
lyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlg

RQFQFTDWPEQGVPkSGEGFIDFIGQVHKTkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERMryeGVvDIFQTVKMLRTQRP-----AMVQTEDQYQF
 ..  ...|  ..| . | | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. ......| .||      .... .||.|
ikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyef

SYRAALEYL
 ..| ||||
ilealleyl

0043147 (Phosphotyrosine protein) phosphatases II 1426-1626 3.8e-47 155.5 In-house 3-154 (172) alignment
Range on Protein: 1426-1626
Range on HMM: 3-154/172.0
PGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLeersrvkcdqywpsrgtethglvqvtlldtvelatycvrtfalYKNGS
.||||.||.|.|.|.. . .||||| |..|. |||||..|.   ..|..|.|                                           .....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SEKREVRQFQFTAWPDHGVPeHPTPFLAFLRRVKT-CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLerikheKTVDIYGHVTLMRAQRNYMVQTEDQYIF
 ..|.. |.... ||||||| ..  .| ||. ... ..  . ||..|||||||||||...... ||      . ....  | |.|..|...||...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IH
..
ly

0043147 (Phosphotyrosine protein) phosphatases II 1715-1917 1.1e-46 154.0 In-house 3-154 (172) alignment
Range on Protein: 1715-1917
Range on HMM: 3-154/172.0
EGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||..|.|.  . .||||||| .|..||||||.|.. |..|.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTVRQFQFTDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQDGPISVHCSAGVGRTGVFITLSIVLERMryegvvDIFQTVKMLRTQRPAMVQTEDQYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FSY
| |
fly

0046846 (Phosphotyrosine protein) phosphatases II 1708-1925 2.5e-46 152.9 In-house 3-174 (176) alignment
Range on Protein: 1708-1925
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFIDGYRqqkaYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||..|.|.|    .||||||| .|..||..||.|.. |.||.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtvrQFQFTDWPEQGVPKSgEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFITLSivleRMRYEGVVDIFQTVKMLRTQRP-AM
              |.....||. ||| . | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDQYQFSYRAALEYLG
|||..||.| |...|..|.
vqtpeQyrflyefellllk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1675-1922 3.9e-46 152.3 In-house 19-293 (297) alignment
Range on Protein: 1675-1922
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE
.|..  | ||. .    |||  .|. ...||| |.  |.. ..||||| ..      ..  || .|||| .| .|||....|..  ..||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| ||  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   ...|| ||. .||| .|... | |.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_ptpA1_pd Subfamily ptpA1 1376-1595 7e-46 151.8 In-house 26-258 (418) alignment
Range on Protein: 1376-1595
Range on HMM: 26-258/418.0
KFSQEYESIDPGQqfTWEhSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGY-RKQnaYIATQGSLPETFGDFWRMIWEQRSATVVMM
.|    ||. | .  | |  . . |  ||||.|..  .|.|| |  |.   ||||.|||||||   ||  .|.||| ||.|  |||||.||.|   .||.
efrlleesvgpse..tse.gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivml

TKLEERSRVKCDQYWPS-----------RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--
..  |  |.|||.|||             | |  |   | |.. ..     . |  .      | |.. |.|.  |||| .|.|  ||  .|. .     
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

--NPP--DAGPMVVHCSAGVGRTGCFIVIDAMLERIKH
   |      |..||||||||||| |     |.... |
qiipssdrnvpiivhcsagvgrtgtfctavimmkkldh

0046846 (Phosphotyrosine protein) phosphatases II 1426-1630 8.6e-46 151.2 In-house 10-170 (176) alignment
Range on Protein: 1426-1630
Range on HMM: 10-170/176.0
PGSDYVNANYIDGYRkqnaYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSrgTETHGLvqvtlldtvelatycvrtfalykngs
...||.|||.|.|.|    .|||||.||.|. ||..|..|..  .||..|.. | .|.||..|||    |..|.                          
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

sekrevrQFQFTAWPDHGVPEHpTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDamleRIKHEKTVDIYGHVTLMRAQRN-YMVQTEDQYIF
       |.... |||||||.. . .| .|. ....   . || .||||||.||||......     ...|| ....  . |.|.||  ..|||..|| |
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

IHDALL
.....|
lyefel

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1386-1631 3.6e-45 148.8 In-house 42-281 (290) alignment
Range on Protein: 1386-1631
Range on HMM: 42-281/290.0
PGQQFtwEHSNLEVNK--PKNRYANVIAYDHSRVLLSaiEGIPGsDYVNANYIDGYRkqNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV
|.|..  | . .. |    |||| .|.  | .||.|.  .| .| ||| |||..| .    .| |||.| .|  |.|||. ... |..||. .| |  . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPSRGTETHGLVQVTLLDTV---ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCnppdAGPMVVHCSAGVGRT
||.||.| .  |.  . ..|.| .    . |    .|... .  |  .  .. ..  .|||. |.     .|  || ...     .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
| |. |.. |. . . | .|. . |  .|  |   || . ||. . ..||.
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1377-1631 1e-44 147.6 In-house 8-257 (267) alignment
Range on Protein: 1377-1631
Range on HMM: 8-257/267.0
FSQEYESIDPGQQFTW--EHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
. .|.| |.   . .     |  | |. .||. ... ||..|| |.  |     .|.|| |..||...||.|.||..|  | .||. .| .|. ...|..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKLEERsrvKCDQYWPSRGTETHGLVQVTLLDTVE--LATYCVRTFAL-YKNGSSekREVRQFQFTAWPdhgVPEHPTPFLAFLRRVKTCNPPD--AGPM
||  .    .  ..|| .  ...   ..|.  ..|     | . |. | .|| |.  ..|  . .  |    .     |.|  |  . . |  .    |.
tkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa..hnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPl

VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
||.||.||||.| |.|||..|||.|.| ..||.  .  .| ||  .|.| ..||.||. | |
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

0049260 (Phosphotyrosine protein) phosphatases II 1435-1627 2.4e-44 146.0 In-house 1-144 (152) alignment
Range on Protein: 1435-1627
Range on HMM: 1-144/152.0
YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWpsrgtethglvqvtlldtvelatycvrtfalykngssekrevrQF
.||||......||||| .|.|. |||||..|.   |.||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLerikheKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
... |||||||...  .| .|. .. ..  . || .|||||||||||...... ||      . |...  | |.|..|...|....|..|...
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0049772 (Phosphotyrosine protein) phosphatases II 1390-1635 1.5e-43 145.1 In-house 36-282 (314) alignment
Range on Protein: 1390-1635
Range on HMM: 36-282/314.0
FTWEHSNLEVNKPKNRYANVIAYDhSRVLLsAIEGIPGSDYVNANYIDGYrkqNAYIATQGSLPETFGDF----------WRMI--WEQRSATVVM----
.|.  ..|..|. |||| ... .| .|| |   ... |||| ||.|.||.   ...||||| |..|. ||          |||.  ..... ..||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTKLEERSrvkcDQYWPSRGTETHglvqvtlldtvelatycvrtfA-------LykngsseKREVRQFQFTAWPDHGVPeHPT
                  ..| ..     .......  . .                             .       .|.. ..  . .||...|  . 
vladelsrLdaAlgKtpllildgng....neptaadlellk.....................eelydpelf.......erlgikylripvpDgsap.lle

PFLAFLRRVKTCnpPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHeKTVDIYGHVTLMRAqRN---YMVQTEDQYIFIHDALLEAVTC
 |..||. ....  .. || .|||.||.||||.|.|.. .. . .     ... .| |.|   |    .... .||.||..||||..  
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylkf

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1396-1631 2.4e-43 143.3 In-house 37-275 (307) alignment
Range on Protein: 1396-1631
Range on HMM: 37-275/307.0
NLEVNKPKNRYANVIAYDHSRVLLSaIEGIpGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE
 .. |  |||| .| . |..|...  ..|.  |||. |||.    | . .|..|| | .|  .|| |. ...  .|.|. |. | ...||.||||    .
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

THGL------VQVTLLDTVELA--TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVID
.         . |. | . .||    ..   .|  . ... | ....|.. |||.|||.     . .|  |.     |  |.||||||||||.|  . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivais

AMLER-IKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
 . .. |. .   |.   |  .|.||.| .||| ||...|  |||
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

0049260 (Phosphotyrosine protein) phosphatases II 1724-1917 4.6e-43 141.8 In-house 1-143 (152) alignment
Range on Protein: 1724-1917
Range on HMM: 1-143/152.0
FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtvrQF
|||||......||||||. .|..||||||.|.. |..||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQDGPISVHCSAGVGRTGVFITLSIVLermryeGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY
... ||  |||.. . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|...|..|| .|....|..| |
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1667-1923 4.8e-43 142.1 In-house 11-258 (267) alignment
Range on Protein: 1667-1923
Range on HMM: 11-258/267.0
E---FKRLASSKAHTSRFISANlpcNKFKNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
|    |.... ..  | .|. .   |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  |  ||. .. ... ...|.|
efelikkisdtsstisqsiaek...nqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYI--LREFKVtdaRDGQSRTVRQFQFTDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqDGP
||    . .. ...|| .  .. .|| ..|.   | .  .|     |.|.   ..  .. |  . .  |  .   |    .  ..| . | . . | . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrP

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
. |.||.||||.| |...   |||.. |||.|||. .. .| ||...|.| ..| . ..   ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1661-1924 2.8e-42 139.8 In-house 15-277 (307) alignment
Range on Protein: 1661-1924
Range on HMM: 15-277/307.0
VTGMELEFKRLASSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVeGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
|. .  ||. ||  . ..       . .|  |||  ..   . .|. .. . |.  |||| | ..    . | .|..|||| .|  .|| |  ...   |
vqalvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktke
.|| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..|||....|...||..|||.   . |...  |.    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

qfGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  ..  |. |||||||||.|  ...|.| ..| . .   |. . |. ||.||.  .||| || . .|  |||.
..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0051082 (Phosphotyrosine protein) phosphatases II 1716-1920 7.5e-40 131.3 In-house 2-149 (151) alignment
Range on Protein: 1716-1920
Range on HMM: 2-149/151.0
GSDYINASFIDGYrqqkaYIATQGPlaetTEDFWRMLWEHNSTIVVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . .|.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryegvVDIFQTVKMLRTQRPAMVQTEDQYQF
  ..|......|||..|.| | . ...|. .. .      ..||. ||||||.||||... | ..|..      |.........| .|| .||...|..|
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

SYRAA
 ..| 
qlfal

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1380-1631 9.2e-40 131.1 In-house 35-287 (305) alignment
Range on Protein: 1380-1631
Range on HMM: 35-287/305.0
EYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipGSDYVNANYIDGY-RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
 |   |  |.        .... ||||..| . |.| |.|.       |||. |||.      .. .|..|| | .|  .|| |. ...   .||. |  
kytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktv

ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVR-------TFALYKnGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVV
|  ..|| ||||    | . |    ... |  .    |       .. |     ..|  ||..|.| ||| |||      | .|  ..  .     |.||
elgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivv

HCSAGVGRTGCFIVIDAMLERIKHEKTVD-IYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|||||.||||  . |. .||.|  .| .  .   |  .| || . .|.. ||.|||  .|.
hcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1379-1643 1.7e-39 130.2 In-house 31-299 (310) alignment
Range on Protein: 1379-1643
Range on HMM: 31-299/310.0
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSaIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
..|  .|  |. .  .   . .  ||||..|.  | ||| |  |.     ||. |||.     ....| .|| |  |  ||||||...|. ..... |  
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvg

ERSRVKCDQYWPSRG-TETHGLVQVTLLD----TVELATYCVrTFA----LYKNGSS--EKREVRQFQFTAWPDHGVPEHPTPFLAflRRVKTCNppDAG
|  | ||  |||| | |||.| ..|| |       |.   .| ||        .  .  ..  |   ..  ||| |||.     .   .|. .      |
eegrpkcvgywpslgvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqv..rhg

PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLeAVTCGNTEVPAR
| |||||||..|... . ..  ...... . ||.   .| .. .|   .||| ||..|.   . . . |.|||  .
pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaek

subfamily_ptpA1_pd Subfamily ptpA1 1682-1884 8.7e-39 128.4 In-house 40-256 (418) alignment
Range on Protein: 1682-1884
Range on HMM: 40-256/418.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRqQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE
   .   |  |||  ||.| . ||| |. |.  |||||||| .|||    | .|.||||| .|  |||||.||    |.|||..  |  | || .||| .
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

RSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF----GQDGPISVHCS
     |. .       .  |     .. |   ||        . .|..| . |.|.  ||.. .|   . | ...  . . ..|      .. || ||||
igg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRTGVFITLSIVLERM
||||||| | |  |.....
agvgrtgtfctavimmkkl

0044763 (Phosphotyrosine protein) phosphatases II 1700-1917 1.4e-38 127.7 In-house 1-164 (178) alignment
Range on Protein: 1700-1917
Range on HMM: 1-164/178.0
PYESTRVCLQPIRGVEGSDYINASFIDGYrqqkAYIATQGPlaettEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||.|...     |.....|     .|....|.|.. | .|.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtvRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryeGVvDIFQTVKML
                      |.... .|  ||| . | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... ....
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDQYQFSY
| .|| .|....|... |
rerRp.ivpnpgqlrqLy

0044763 (Phosphotyrosine protein) phosphatases II 1412-1630 2.3e-38 127.0 In-house 2-168 (178) alignment
Range on Protein: 1412-1630
Range on HMM: 2-168/178.0
YDHSRVLLSAIEGIPGSDYVNANYIDGYrkqnAYIATQGSlpetfGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTethglvqvtlldtvela
.|..||||| .||...||| ||..|...     |......      |......|.   ..|..|.  |. ..|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tycvrtfalykngssekrevRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERikhekTVDIYGHVTLMRAQ
                     |.... .||||||. .  ||.|.. .... ... || .|||||||||.|...... |...      ....  . |.|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYIFIHDALL
|. .|....|. ....  |
Rp.ivpnpgqlrqLyefel

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1682-1923 6.5e-38 125.0 In-house 30-268 (281) alignment
Range on Protein: 1682-1923
Range on HMM: 30-268/281.0
ISANLPCNKFKNRLVNIMPYESTRVCLQP-IRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA
   | | |. ||| .||   . .|| |.  .   . .||| | .|     .. || ||||  ||  |||||.|. |.| .||| .. |  |||| .|.| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSIV
.  .  |.  .    |    .  |   ..  . .|..| . .. . .||.  ||.| | ..  . ...       .  |  .||||||||.| .... | 
nahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveia

LERMRY-EGVVDIFQTVKMLR-TQRPAMVQTEDQYQFSYRAALEY
|. ..    . || | |  || | | | ||| .|| . ..  |..
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1394-1631 7e-38 124.9 In-house 31-267 (281) alignment
Range on Protein: 1394-1631
Range on HMM: 31-267/281.0
HSNLEVNKPKNRYANVIAYDHSRVLLSA-IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR
  |  ||. ||||.|. . | ||| |   .     .||. ||||     .  || |||   ||  |||||||.. ....||. .. |  | || .|.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

GtetHGLVQVTLLDT-VEL--ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCnppdAGPMVVHCSAGVGRTGCFIVIDAM
    |  .|.  |    |       . |  |      | | . .. .  |||  |||    .|  ||....     . | |.||||||||.| .. ..  
a...hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveia

LERIKHEKT-VDIYGHVTLMRA-QRNYMVQTEDQYIFIHDALLE
|. |.   |  ||   |. .|   |   ||| .||..|   ||.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

0051082 (Phosphotyrosine protein) phosphatases II 1427-1630 1e-37 124.4 In-house 2-150 (151) alignment
Range on Protein: 1427-1630
Range on HMM: 2-150/151.0
GSDYVNANYIDGYrkqnaYIATQGSLPetfgDFWRMIWEQRSATVVMMTKLEERSrvKCDQYWPSRGtethglvqvtlldtvelatycvrtfalykngss
 ||| |..|..|.     .....| |.    ||.....|.   |.|.....|||   .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnpPDAGPMVVHCSAGVGRTGCFIVIDAMLERikhektVDIYGHVTLMRAQRNYMVQTEDQYIFIH
  .||...... |||.|.|...  .|.||. .     .. ||..||||||.||||...... ||..      |...  .  .|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DALL
 |||
fall

PTPc_DSPc_SM00012 1819-1922 1.2e-37 123.7 In-house 1-105 (105) alignment
Range on Protein: 1819-1922
Range on HMM: 1-105/105.0
TVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSY
||.....|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . |||||.||.||.||| |||||.||.| |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAALE
|| ||
ralle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1396-1633 1.4e-37 124.2 In-house 31-270 (285) alignment
Range on Protein: 1396-1633
Range on HMM: 31-270/285.0
NLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGY-RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT
  | |   ||||.| . . .||.|   .     ||. |...    . |..||.||| ||||. |||.||.... | |.|.  | |    ||  |.| .  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

ET--HGLVQVTLLDTVELATYC----VRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDA
|    |  ..|| .  | |         |    .. |||   . . |   |||.  ||   |.. . . ||  || .  |..||||||||||  |. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidy

MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
   ||  .  ...   |  ||| |   ||.  |..|..  |.| .
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf

PTPc_DSPc_SM00012 1531-1631 2.9e-36 119.2 In-house 2-105 (105) alignment
Range on Protein: 1531-1631
Range on HMM: 2-105/105.0
VRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDA--GPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
|.....|.||||||||.....| .|| ||...   .  .|.||||||||||||.|...| .|.....| |.|||.  |  .| ||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1691-1924 3.7e-36 119.3 In-house 58-283 (290) alignment
Range on Protein: 1691-1924
Range on HMM: 58-283/290.0
FKNRLVNIMPYESTRVCLQpiRGVEGsDYINASFIDGYRqqKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|..|. |.|||. ... . .||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |..|   ..  .  . |.       ||. ||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .|. ..|. ||  | . || . ||    .. |.. 
keldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1401-1631 2.6e-35 116.6 In-house 49-285 (305) alignment
Range on Protein: 1401-1631
Range on HMM: 49-285/305.0
KPKNRYANVIAYDHSRVLLsaiEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH---
. |||| .|   |. || |   ||    .|. |||.    . . .| ||  | .|  ||| | ....  .. |. .| |.   || .|..|.  ..    
agknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---GLVQVTLLDTVEL-----ATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKtcnpPDAGPMVVHCSAGVGRTGCFIVIDA
     ..| .  .|.|     |   |.   |  .|. ...| | .. .  ||| |||   .  | .| . .    |  ||.|||||||.||||  .... 
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmley

MLERIKHEKTVDIYGHV-TLMRAQRNYMVQTEDQYIFIHDALLE
.|...   . ..   ..   .| |||  .||..||.|.|. .|.
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1689-1924 6.2e-34 112.0 In-house 55-289 (305) alignment
Range on Protein: 1689-1924
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGY-RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   . . | |.       |||| | ..      .| .|..|||| .| ..|| |. ...   .||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqfGQDGPISVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. .||..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||..  .  .  . . || || ||   .|.. || | .|  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1720-1913 1.9e-33 110.5 In-house 78-270 (301) alignment
Range on Protein: 1720-1913
Range on HMM: 78-270/301.0
INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | .|.   . . .||||||| .|.|||| ||  ..   .|||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY
 ..|||  .|...|...|||||     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||. | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1400-1554 2e-33 110.5 In-house 33-189 (297) alignment
Range on Protein: 1400-1554
Range on HMM: 33-189/297.0
NKPKNRYANVIAYDHSRVLLSaiEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT--E
   |||| ...|.| .|| |    .|...||.||.|.      ..  || .|| | .|  |||....||   ..||..||.|  | ||  ||||      
slrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

THGLVQVTLLDT--VELATYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAF
. | | |  | .   |  .  .  . |.    ||.| ||  || .|||||||        |
kagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf

subfamily_CG42327_pd Subfamily CG42327 1400-1560 1.2e-32 107.9 In-house 28-192 (319) alignment
Range on Protein: 1400-1560
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR----GT
 |.|.|..||.   ..|| |  |   . . |..|.|. ||.. .| |||.| || ..  ||||..|||.| ..| .|.| |    .| .|.|..    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFtAWPDHGVPEHPTPFLAFLRRVKT
...| ..||| .      | . |. | .   .| ||.  . .  |.. .|| ......| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1673-1924 1e-31 105.1 In-house 27-271 (288) alignment
Range on Protein: 1673-1924
Range on HMM: 27-271/288.0
SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE
 |  ..|  |  .   |  ..|  |.   . ||| |.     .   ||.|  .   . ..  | .| ||  | | .|.|| | .   .|||..| | |.|
dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCHQYWPAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVG
|  .|.| .   .||.. .  .   ...  . ...   .   . |. .  |..  . .|...|||..   .. ..  .         . || ||.|||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvG

RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||| .|   |.|| .| .  . | . .. || .|   .||| || . .|  ||.|
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1400-1635 3.7e-31 103.2 In-house 43-273 (288) alignment
Range on Protein: 1400-1635
Range on HMM: 43-273/288.0
NKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGL
|  ..|| |.   | .|| ||         |..|| .   . ..  | .|  |  | . .|.|. |.    .||...| |. . | ..|.||.  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

V---QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVVHCSAGVGRTGCFIVIDAMLERIKHE
    .|.  . ...    . .    ..   ||  |..  .  |.|.||||   ..| .| ..|...     |.|||.|||||||| .|.|  .|| .. .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrld

KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
  . |   .. .|..|   .||| ||...|  .|| .  
dflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1689-1924 4.3e-31 102.9 In-house 35-270 (285) alignment
Range on Protein: 1689-1924
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYESTRVCLQPirgvEGSDYINASFID-GYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| ||  |||.|... . . |.||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  |.  .  ..... |. .|. |   ||.  |. | |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1689-1924 3.4e-30 99.8 In-house 48-287 (305) alignment
Range on Protein: 1689-1924
Range on HMM: 48-287/305.0
NKFKNRLVNIMPYESTRVCLQPirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQY
.. |||  ..   .  || |..       .|| | ..    . | .| || || .|  ||| | ....   . || .| | | .||..|....     ..
eagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

F------VVDPMAEYNMP------QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFIT
       .|   .  ..         . .   | .   ...| | .. . |||..||| .    .... .   .|      ||| ||||||.||||  . 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvm

LSIVLERMRYEGVVD-IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|  .|...    ...   . .. .| ||   .||..|| | ..  |.|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_CG42327_pd Subfamily CG42327 1687-1851 1.3e-28 94.6 In-house 26-194 (319) alignment
Range on Protein: 1687-1851
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK-AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| ... ||||..|| .| ..| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFtDWPEQGVPKSGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .|| . . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl

0048076 (Phosphotyrosine protein) phosphatases II 1503-1630 1.4e-28 94.8 In-house 18-140 (145) alignment
Range on Protein: 1503-1630
Range on HMM: 18-140/145.0
TLLDTVELATYCVRT-FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDAMLErikheKTVDI
| ||  .|. . ..| . |  . . ..|.. |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.     . |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

YGHVTLMRAQRNYMVQTEDQYIFIHDALL
.  . |.|.|| ..|....|..|.....|
eealelvrsqrpgavpnpgqlrflyefel

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1396-1624 6.4e-28 92.4 In-house 46-272 (301) alignment
Range on Protein: 1396-1624
Range on HMM: 46-272/301.0
NLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPgsdyVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT
.  ..| |.|| .|    .. | ...  . .|    . ||.|.   . . .||||| |..|  ||| |.      ..||...  |.   ||..| |.. .
yaylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

ETHGL--VQVTLLDTVELAT--YCVRTFALYK-NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVVHCSAGVGRTGCFIVIDAM
|.  .   .... ..  .       ||. .    |  . | |  .|.. |.|.|||.  .    ..  ||  .     |.|||||||.||. .||  . .
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteyl

LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
  ... ..|...   .  .| .|   |||. |  .
areveadptieltealkhlrehrwngvqtnsqlyw

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1520-1655 2.4e-27 90.3 In-house 81-216 (440) alignment
Range on Protein: 1520-1655
Range on HMM: 81-216/440.0
LYKNGsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT
 | ||  | | ..|... .|||.|||.   | | ... |. ..     ||..||||||.||||  |..|..|   |.   .||.  .  || .|  ||||
sying.iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI
 .|| |.|.|.||.. ||.| .   ..   ....   
peqyafvheavlegllcgdtliledditerveqiqwp

0048179 (Phosphotyrosine protein) phosphatases II 1513-1627 2.6e-27 90.7 In-house 31-139 (144) alignment
Range on Protein: 1513-1627
Range on HMM: 31-139/144.0
YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDAMLerikHEKtVDIYGHVTLMRAQR
..| ...      ...||. |.... |||||||.... .|.||. .... ... ||..|||||||||||...... |.    ... ....  . |.|..|
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

NYMVQTEDQYIFIHD
 ..|....|..|...
pgavpnpgqlrfLle

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1729-1918 4.1e-27 89.6 In-house 2-198 (199) alignment
Range on Protein: 1729-1918
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQ
. |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.| |.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1730-1918 5.3e-27 89.3 In-house 2-197 (198) alignment
Range on Protein: 1730-1918
Range on HMM: 2-197/198.0
QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQF
 |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.| |.
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1401-1634 9.1e-27 88.6 In-house 44-277 (312) alignment
Range on Protein: 1401-1634
Range on HMM: 44-277/312.0
KPKNRYANVIAYDHSRVLLSAIEGIpgsdYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR----GTET
|  ||| |.  .|  |  |.  | .    |. ||..    | . ...||| | .|   ||..     |....... . | .  || .|          | 
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

HGlVQVTLLDTVELATY-----CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVIDAMLE
|  |       .|.          | . .  . . ..  . ..|...|||||.|.     | .|  ||     |  |.. |||||||||| ...|..|. 
hr.vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmia

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
 ..| .  ..     |.| .|   |..  ||..   ..|| . 
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_egg_pd Subfamily egg 1391-1630 3e-26 86.8 In-house 31-267 (307) alignment
Range on Protein: 1391-1630
Range on HMM: 31-267/307.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrVKCDQYWP
. ...  . |. | |   |   | ||| |   .|    |.. ||...|    | .| .|  | .|  |||||.....   .||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

SRGTETH----GLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQftaWPDHGVPEHPTPFlAFLRRVKTCnppdAGPMVVHCSAGVGRTGCFIV
   ...     | .... |.  . |    |   |   |   |.| .  .|   .  . . .  .|.   ||...      . |.||..  || ...... 
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvyspl.rvlrklrnl....skpvvvqdilGvskaatlva

IDAMLER-IKHEK-TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
|.  |   ..       .   | ..| .|.. |..  .|.|..  .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1688-1920 8.9e-26 85.2 In-house 51-286 (310) alignment
Range on Protein: 1688-1920
Range on HMM: 51-286/310.0
CNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARY
 .  |||  ...  ...|| |. |      ||| | ..     ....| .||||  |  |||||...  .  ...| |  | || ||  |||.   .  |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

QYFVVDPMAEYNMpQYILREFKVTDA-----RDGQS-----RTVRQFQFTDWPEQGVPKSGegfIDFIGQVHKTkeQfGQDGPISVHCSAGVGRTGVFIT
    |  ..|    .. . .. ||        | |        |   .. .||..|||         . |   .  |  . ||  ||||||..|..| ..
gcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvva

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
| . .....    ||. . .  |. .|   .||| || .  |  
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_egg_pd Subfamily egg 1661-1921 3.6e-25 83.3 In-house 13-267 (307) alignment
Range on Protein: 1661-1921
Range on HMM: 13-267/307.0
VTGMELEFKRLASSKAHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
| ..|  .. |  |  . |   .|.   |. | |   .   .|.|| |.  ||    |.| |  ..|      .| .| || .| .|||||... .   .
vqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtvRQFQFTDWPEQGVPKSGEGFIDFigQVHKTKEQFG
||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .|.. .  .  .| .   .  
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnls

QdgPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL
.  |. |..  || ........ | |  .    .    . ..|..|| .|.  |..  .| | ||  |
k..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

0048076 (Phosphotyrosine protein) phosphatases II 1803-1923 1.3e-24 82.0 In-house 36-142 (145) alignment
Range on Protein: 1803-1923
Range on HMM: 36-142/145.0
IlrefkvTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQ
.      |. ... .|.. |.....||  ||| . | ...|. ....  ..   .||. |||||||||||...    ..  |...| |.........|.|
l......tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsq

RPAMVQTEDQYQFSYRAALEY
|| .|....|..| |.. ||.
rpgavpnpgqlrflyefelel

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1692-1930 1.2e-23 78.3 In-house 46-282 (312) alignment
Range on Protein: 1692-1930
Range on HMM: 46-282/312.0
KNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| .|.  ||..     || ...|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| | .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
.|.    .. ..  .|| .|   |..  || .. |. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1691-1780 1.5e-23 78.1 In-house 49-152 (350) alignment
Range on Protein: 1691-1780
Range on HMM: 49-152/350.0
FKNRLVNIMPYESTRVCLQ----P----IRGVEGSDYINASFIDGY----RQQKA--YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
 ||| .||.||| .|| |.    .       ....|||||...       ...    |||||.|| .| .||.... . . .....||.. |...|||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPA
||. 
YWqe

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1569-1636 2e-23 76.5 In-house 1-68 (69) alignment
Range on Protein: 1569-1636
Range on HMM: 1-68/69.0
MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG
||||||.| |||| || |   . ||| || |||.  |  ||  |  ||  | .|||||||| ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1816-1925 5.2e-23 76.1 In-house 87-195 (440) alignment
Range on Protein: 1816-1925
Range on HMM: 87-195/440.0
QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|||  .. .| .|| |||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

SYRAALEYLG
 . | || | 
vheavlegll

0048179 (Phosphotyrosine protein) phosphatases II 1805-1915 1.8e-22 75.0 In-house 48-136 (144) alignment
Range on Protein: 1805-1915
Range on HMM: 48-136/144.0
RefkvtdardgqsrtVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEGvVDIFQTVKMLRTQRP
               . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||||.....     .|...| ..........|..||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQTEDQYQF
 .|....|..|
gavpnpgqlrf

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1570-1636 2.6e-22 73.0 In-house 1-67 (69) alignment
Range on Protein: 1570-1636
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG
|||||.| |||| || |   . ||| || |||.  |  ||  |  ||  |..|.|||||| ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1402-1497 3.1e-22 73.8 In-house 49-158 (350) alignment
Range on Protein: 1402-1497
Range on HMM: 49-158/350.0
PKNRYANVIAYDHSRVLLS-------AI-EGIPGSDYVNANYIDGY---RKQN---AYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
 |||| |.. |.|||| |        |.   . ..||.||||.       ..|    |||||. ||.|. ||...| .     ....|.. |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSRGTETH
||.  . . .
YWqegsyddi

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1442-1631 6.6e-22 72.8 In-house 34-219 (255) alignment
Range on Protein: 1442-1631
Range on HMM: 34-219/255.0
QNAYIAtqgslpeTFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQFTAW
.| |.        |   |...|  ... .|||.. ..| ...||..|.|    |   | .|..  |   |   .||  .  . .   . ..|. .... |
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW

PDHGVPEHPTPFLAFLRRVKtcnppDAGPMVVHCSAGVGRTGCFIVIDA----MLERIKHEKTVDIY--GHVTLMRAQRNYMVQTEDQYIFIHDALLE
...  || .   |  |. |.     |. ..|||||.|.||.  |....     |.  ..  .||..     .. .| .|.  ..|  |  |    .|.
ieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1441-1626 1.5e-21 71.5 In-house 3-197 (199) alignment
Range on Protein: 1441-1626
Range on HMM: 3-197/199.0
KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQF
 |  ||||| .| ||. |||.|.||  |  .||.   .    .    |||.   ||  .| . ||    .  . |.. .. | .| ..    ||. ..||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPEHPtPFLAF---LRRV-KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIH
|.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1442-1626 2.1e-21 71.0 In-house 3-196 (198) alignment
Range on Protein: 1442-1626
Range on HMM: 3-196/198.0
QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQFT
|  ||||| .| ||. |||.|.||  |  .||.   .    .    |||.   ||  .| . ||    .  . |.. .. | .| ..    ||. ..|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPEHPtPFLAF---LRRV-KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIH
.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

fn3 Fibronectin type III domain 922-1006 1.5e-19 63.1 Pfam-A 3-85 (85) alignment
Range on Protein: 922-1006
Range on HMM: 3-85/85.0
PQNLHSEGTTSTSVQLSWQPPVlaERNGIITKYTLLYRDINIPLlPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSKGPGPYS
|.||. ...||||..|||.||   ...| ||.|.. ||. . .  .  .  ||..| ..|||||||.|.| ..|.|.. .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1661-1923 1.8e-19 64.3 In-house 25-284 (302) alignment
Range on Protein: 1661-1923
Range on HMM: 25-284/302.0
VTGMELEFKRLASSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETT---EDFWRMLWEHNS
 . .. |||.... |... .        |  ||.  ..  ..|..| |.     |  .|.||| ..    ..  | .| |  ...   |.|||| .... 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

TIVVMLTKLREMGReKCHQYWP--AERSARYQYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKE
. ||.| .  |. .   ....|  ..    |. . |     |.   .    .. .    .| | .|      .| |... ||..    |  . .|   ..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fak

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
.   | .. .    |.|| |.|.|| ...|..  .  . | ..|| .|.|||..|.. .|| . |.|.| |
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1454-1625 2.7e-19 63.7 In-house 102-280 (302) alignment
Range on Protein: 1454-1625
Range on HMM: 102-280/302.0
ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVT--LLDT-VELATYC-VRTFALY-------KNGSSEKREVRQFQFTAWPDH
.|   .| .| . . | || .... |    || .|.  .  ..  . . |   ..   .|. .   ..| ||       |  .  |. |  ..|.|||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPEHPTPFLAFLRrvkTCNPPDAgPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFI
| |... . |  |.    |.      ..||||||||||| .. |   ..  ...|. |.   |. .|. |   ||.|.| |..
Gapkeaytaldilk...fcesykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

fn3 Fibronectin type III domain 612-699 4.2e-19 61.6 Pfam-A 2-85 (85) alignment
Range on Protein: 612-699
Range on HMM: 2-85/85.0
PPQDISCTSPSSTSILVSWQPPPveKQNGIITEYSIKYTAVDGEDDKPHEIlgIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES
.|...|... .|||. .||.||.  ...| || |...|  ..|.... .    .|..|| . |..|.  |||...|.|....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeft..vprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1399-1633 1.7e-18 61.3 In-house 46-279 (303) alignment
Range on Protein: 1399-1633
Range on HMM: 46-279/303.0
VNKPKNRYANVIAYDHSRVLLSAiegipgSDYVNANYIDGYRKQNAyIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT---E
 |  |||...||  |||.| ||       | |. |.|..   ...| | ||  |. |  |||.|| ||.   |...    |  ..  |  .|        
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

THGLVQVTLLDTVELATYCVRTFALYKNGSsEKREVRQFQFTAWPDHGVPEHPTP-FLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAM-LE
 .  ..|  .  |||.   |       ||.  |  .   .. |||   .| . .| |.  . ....   .  |. | |    .|.||.| | ....  | 
eersirvgefkrvelgdgwvlkvlsvsngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
  . . ..|.   .  .|  | . ||   |. ...  | | |
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1744-1924 4.3e-18 60.3 In-house 40-221 (255) alignment
Range on Protein: 1744-1924
Range on HMM: 40-221/255.0
TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFI
| . |....   ... ||||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .||. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .  |...|       .. ||||.|.||.  |.   .|  .|    .    . .|  . .. || .|.. ..|  |  ||    |...
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

fn3 Fibronectin type III domain 518-595 6.4e-18 57.9 Pfam-A 2-83 (85) alignment
Range on Protein: 518-595
Range on HMM: 2-83/85.0
QPLNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEHGE-EQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGA
.| |..... ..||. |||.||.  ...| .||. |.. ..|| ....|... | |. |.||||.. | ||..|.. .| | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1726-1913 6.8e-18 59.1 In-house 84-277 (302) alignment
Range on Protein: 1726-1913
Range on HMM: 84-277/302.0
DGYRQQKAYI-ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  .|.| .| .. ..| .||| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIgqvhKTKEQFGQDgpISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY
. . .||  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|.| 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql





fn3 Fibronectin type III domain 325-405 7.2e-18 57.7 Pfam-A 2-85 (85) alignment
Range on Protein: 325-405
Range on HMM: 2-85/85.0
PPGTPVVTESTATSITLTWDSG--NPEPVSYYIIQHKPKNSEE--LYKEIDGVATtRYSVAGLSPYSDYEFRVVAVNNIGRGPPS
.|. . |.| |.||.||.|.    . .|...| .. ..|...|    . ... .| .. . || |...||||| |||. | ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 714-812 9.5e-18 57.3 Pfam-A 2-85 (85) alignment
Range on Protein: 714-812
Range on HMM: 2-85/85.0
PPRKVEVEAVNSTSVKVSWRSPVpnKQHGQIRGYQVHYVRMENGEpkgqpmlkdvmlaDAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS
.|. . |..|.|||. .||  |   ...|.| ||.|.|  ...||             . ..   . |.. ....||.| |.|...|.|....| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_hpo-7_pd Subfamily hpo-7 1442-1634 1.7e-17 58.2 In-house 37-228 (263) alignment
Range on Protein: 1442-1634
Range on HMM: 37-228/263.0
QNAYIAtqgsLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS--SEKREVRQFQFTAW
.| |.     | .|   |...|  ... .|||..  .| ...||..|.|    |   | .|..  |       ..|  | .. .   . ..|...... |
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgW

PDHGVPEHPTPFLAFLRRVKtcnppDAGPMVVHCSAGVGRTGCFIVIDA----MLERIKHEKTVDIY--GHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
...  || .   |  |. ..     .  ..|||||.|.||.  | |..     |.  ..  .||..     .. .| .|.  ..|  |  |    .|. |
iekndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

T
 
l

fn3 Fibronectin type III domain 419-504 7.3e-17 54.5 Pfam-A 1-85 (85) alignment
Range on Protein: 419-504
Range on HMM: 1-85/85.0
SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHvnNWMKHNVADSQ-ITTIGNLVPQKTYSVKVLAFTSIGDGPLS
|||......  .||.. ..|..|....|.|.||.| | .. ...   |   .|  ..   |. .| | ..|...| | .  | || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

I-set Immunoglobulin I-set domain 24-115 8.9e-17 52.7 Pfam-A 1-90 (90) alignment
Range on Protein: 24-115
Range on HMM: 1-90/90.0
PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDgSGSVLRIQPLrTPRDEAIYECVASNNVGEISVSTRLTV
|.||... |..   |  ... |...|.| |.. | |.|.......   ..... . . |.|.   ...|| .|.|.|.|..|. . ...|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnv.evsDeGkYtckatnsagkaeakaeLkV

subfamily_CG42327_pd Subfamily CG42327 1856-1923 1.2e-16 55.3 In-house 246-314 (319) alignment
Range on Protein: 1856-1923
Range on HMM: 246-314/319.0
QDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
. ||. |||| ||||||. |.  | ....      ||| |.|  .| .|   |.| .||.| |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1357-1450 7.4e-16 52.1 In-house 5-95 (95) alignment
Range on Protein: 1357-1450
Range on HMM: 5-95/95.0
IPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipGSDYVNANYIDGYRKQNAYIATQG
| .  .  |.  ...| . .| .|. ||      ..     | | ||||. |.. || .|| |..      |||.|| ..||| ..|.|||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1692-1916 8.4e-16 52.9 In-house 22-251 (290) alignment
Range on Protein: 1692-1916
Range on HMM: 22-251/290.0
KNRLVNIMpYESTRVCLQPIRGVEGSDYINASFIDgYRQQKAYIATQGPLAET-------TEDFWRMLWEHNSTIVVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |....        |.|| |  . ... |||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  ||   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFS
.    .   .| | . . .|.|| ||  ..... .. | 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1526-1630 9e-16 52.5 In-house 212-341 (350) alignment
Range on Protein: 1526-1630
Range on HMM: 212-341/350.0
SEKREVRQFQFTAWPDHGVPEHPTPFLAFLR----------RVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE------RI----K----HEKTVD-
|.  .| |.|.  |.| ..  .|  .|  |             .  .   . |..||||||||||| .. .| .|.       .    .      || | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IYGHVTLMRAQRNYMVQTEDQYIFIHDALL
|   |  .| ||  |||. ||.|||..|||
isiivnelrkqrismvqnldqfifiYeall

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1683-1781 1.8e-15 51.2 In-house 90-181 (244) alignment
Range on Protein: 1683-1781
Range on HMM: 90-181/244.0
SANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrekCHQYWPAE
 |  | | .|||    .|..  || |   .|  |  ||||||.    .   || || |||.|. |||.|. |    ..|.|  . |       .|||  
dafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1395-1630 2.2e-15 50.9 In-house 46-282 (302) alignment
Range on Protein: 1395-1630
Range on HMM: 46-282/302.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGYRKQNAYIATQGSLPET---FGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWP-
.    |  ||.  .| ..|. .| |.| .     .||||  ..    ..  | .|    ..     .||||..... ..||.. . || ..   ....| 
kafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk

-SRGTETHGLVQVTLLDtVELATYCVRTF--ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID
 |   ...| . |     || |   .  .   .  .| |.   .    .| |... ||.. .   .    | . . .   ..|.    |.|| | |..  
ksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltla

AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
. .|.....| . |   |. .|.||  .|.. .||.... |||
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1862-1923 3.1e-15 50.3 In-house 2-63 (69) alignment
Range on Protein: 1862-1923
Range on HMM: 2-63/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  |..| | . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1861-1923 3.3e-15 50.2 In-house 2-64 (69) alignment
Range on Protein: 1861-1923
Range on HMM: 2-64/69.0
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
 ||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  | .| | . |  | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_hpo-7_pd Subfamily hpo-7 1736-1923 3.6e-15 50.6 In-house 42-226 (263) alignment
Range on Protein: 1736-1923
Range on HMM: 42-226/263.0
AtqgpLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGV
     | .| . |....   ... ||||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .||...... |.|.  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKSGEGFIDFIGQVHKTKEqfgqdgpISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
|.  .  .  .  . . |.       . ||||.|.||.  |    .|  .|    .    . .|  . .. || .|.. ..|  |  ||    |..
pelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf

subfamily_CG42327_pd Subfamily CG42327 1565-1629 3.7e-15 50.4 In-house 246-311 (319) alignment
Range on Protein: 1565-1629
Range on HMM: 246-311/319.0
DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL
. ||.||||| ||||||  |  |  ......  ..|||   |  .| .|   |.| .|| ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1820-1923 3.7e-15 50.5 In-house 217-343 (350) alignment
Range on Protein: 1820-1923
Range on HMM: 217-343/350.0
VRQFQFTDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE-------------RMRY-EGVVD-IFQTV
| |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.             .. .   . | |...|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KMLRTQRPAMVQTEDQYQFSYRAALEY
. || ||  |||. ||. | | |.| |
nelrkqrismvqnldqfifiYeallfy

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1401-1628 1.2e-14 49.1 In-house 20-254 (290) alignment
Range on Protein: 1401-1628
Range on HMM: 20-254/290.0
KPKNRYANVIAyDHSRVLLSAIEGIPGSDYVNANYIDgYRKQNAYIATQGSLP-------ETFGDFWRMIWEQRSATVVMMTKLEERSRV----KCDQYW
. ..|... ..  ..|| |        .||. ||..  . .  . |.||  .         |  .|| |. . ..  |||. . ||.|.      | .| 
emdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PSRGTE--THGLVQVTLLDTVELATYCVRTFALyKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKtCNppdAGPMVVHCSAGVGRTGCFIVID
| .  |  . . ..|   . ..     .|.  . | .  |.  |   ..  | .  |.|..  .|. .. || ..     |..|||  |. |  ..  |.
pesvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaii

AMLERIK-HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA
     |   .. | .   .  .| ||. ..... .. |.  .
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag

I-set Immunoglobulin I-set domain 127-216 1.3e-14 45.8 Pfam-A 2-82 (90) alignment
Range on Protein: 127-216
Range on HMM: 2-82/90.0
TIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDflpvD----TsnnNGRIKQLRSEsiggtpIRGALQIEQSEESDQGKYECVATNSAGTR
...  ..  .|.   .... | ..|.|.|...|.||    .    .   . |.|   .|       .  | |.. |.||.|||.|.||||||..
kftqklkdvevseGesvelectveGepepsvsWakd....gselks...sqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagka

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1564-1633 3.2e-14 47.5 In-house 226-295 (297) alignment
Range on Protein: 1564-1633
Range on HMM: 226-295/297.0
PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|   ...|||||||||.|  .  |..|.......  |.   .. .| ||  .||| .|. ...|| |. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1688-1920 9.1e-14 45.7 In-house 46-275 (303) alignment
Range on Protein: 1688-1920
Range on HMM: 46-275/303.0
CNKFKNRLVNIMPYESTRVCLQpirgveGSDYINASFIDGYRQQKAyIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-RY
 |  |||.|...  . ..| |        | || ||...   ..|| | || ||. |. |||.|. | .   |..|    |. .   .  .| ..   ..
knmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

Q--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRTV-RQFQFTDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE
.  .  |  . . .. .     .||    .|. ..     .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .     
eersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
 .   .  .|. . ....|  |   ||   |. . |   
slhseqasldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1667-1739 1.2e-13 45.0 In-house 28-95 (95) alignment
Range on Protein: 1667-1739
Range on HMM: 28-95/95.0
EFKR--LASSKAHTSRFISANLPcnkfKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGYRQQKAYIATQG
|||   ..|  ..|     ||.|    |||..||.||..|||.|   |    |||||| |.||| ....|||.||
efksismtsgapytvgsseanip....knrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_eak_pd Subfamily eak 1406-1559 5.5e-13 43.0 In-house 57-208 (332) alignment
Range on Protein: 1406-1559
Range on HMM: 57-208/332.0
YANVIAYDHSRVLLSAIEGIPgSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG--TETHGLVQVT
  ... ||.  | |..    .   |.||  ..     . || |  .  .    ||.|. ||.| ..|.. .  |    | |.|.| ..     .| ..|.
vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

LLDTVELATYCVRTFALYKnGsSEKREVRQFQFTAWPDHGVPEHpTPFLAFLRRVK
  . |. . . .| . | | |  |  .|  ...  | .  .|     |||. . .|
rkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpky.edflalrkvmk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1402-1497 7.1e-13 42.6 In-house 50-161 (349) alignment
Range on Protein: 1402-1497
Range on HMM: 50-161/349.0
PKNRYANVIAYDHSRVLLSA--------------IEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC
 |||| ... |.|||| |                 ..    ||.||||.       .. |||||  || |  ||...|  ..   |. ... .| |  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPSRGTETH
|.||     . .
diywqelsysni

subfamily_eak_pd Subfamily eak 1692-1843 8.3e-13 42.4 In-house 55-203 (332) alignment
Range on Protein: 1692-1843
Range on HMM: 55-203/332.0
KNrLVNIMPYESTRVCLQPIRgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. | .|  .|.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSgEGFIDF
|    |. . . ||.  ..   .  ..  |  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1356-1438 9.2e-13 42.3 In-house 5-85 (440) alignment
Range on Protein: 1356-1438
Range on HMM: 5-85/440.0
PIPILELADHIERLKanDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG
|| . ..||...  .      | .|.  .  | .   . ..|  || |||| |..|||||||.|  ..|.| |||.|| ||.|
piivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1400-1522 1.8e-12 41.4 In-house 34-157 (332) alignment
Range on Protein: 1400-1522
Range on HMM: 34-157/332.0
NKPKNRYANVIAYDHSRVLLSAIEGIpgSDYVNANYIDGYRKQNAYIATQGSLPE-TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG
|   ||   . ..||||| |.  .|    |. ||...||| |..||| .|  . . |   ||||. |.. . ....  ..|. . |.      || |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

LVQV--TLLDTVELATYCVRTFALYK
| ..    |. .|| .  .| |   |
lhefgaksleecelkakicrkfwpek

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1692-1779 1.3e-11 38.4 In-house 51-154 (349) alignment
Range on Protein: 1692-1779
Range on HMM: 51-154/349.0
KNRLVNIMPYESTRVCL----QPIRGVEGS----------DYINASFIDG--YRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| ..    .  .| ||||| ||  | .||....   .  .|. |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1707-1832 7e-11 36.5 In-house 11-125 (130) alignment
Range on Protein: 1707-1832
Range on HMM: 11-125/130.0
ClqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILR
         | .||||||.    . . |. || |||.|. |||.|. |    ..|.|  . |       .|||       |.  ..  ... .  ..|  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdefknika

EF-KVTDARDGQSRTVRQFQFTDWPEQG
.. .. .      ...  || ..|| .|
snleiesdlneshqaltmfqisnwpsdg

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1689-1773 1.2e-10 35.4 In-house 34-117 (332) alignment
Range on Protein: 1689-1773
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYESTRVCLQPIRGVEgsDYINASFIDGYRQQKAYIATQGPLAETTED-FWRMLWEHNSTIVVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. |.. ......  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1437-1517 1.4e-10 35.1 In-house 230-308 (440) alignment
Range on Protein: 1437-1517
Range on HMM: 230-308/440.0
DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSrvkCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRT
.|| |.||.||||  |  |  ||||.. . | .|..|. .|....   |  |||    . | |   |    . ..    |||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1726-1805 2.9e-10 34.1 In-house 230-307 (440) alignment
Range on Protein: 1726-1805
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  |  ||||.. ... . ..|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr

Ig_2 Immunoglobulin domain 133-223 3.7e-10 31.7 Pfam-A 8-78 (80) alignment
Range on Protein: 133-223
Range on HMM: 8-78/80.0
QlKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNgrikqlrsesiggtpirgaLQIEQSEESDQGKYECVATNSAGTRYSAPANL
.  ||.   . |. |.|.|||.|...| ||  ....| |.                   | | . ...|.|.|.|.|.|| |   | . ..
p.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna...................lfipnvsaedsGtYtCrasnsegskqsnsvev

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1852-1924 4.3e-10 33.4 In-house 260-344 (349) alignment
Range on Protein: 1852-1924
Range on HMM: 260-344/349.0
EQFGQDGPISVHCSAGVGRTGVFITLSIVLE----------RMRYEGVV--DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 .  |  .. |||||| |||||..|| ..|.          .. .. .    |. .|  || || .|||   |. . | | |.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1668-1728 7.8e-10 32.6 In-house 28-86 (440) alignment
Range on Protein: 1668-1728
Range on HMM: 28-86/440.0
FKRLASSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGY
.  | |. .. |    |.|| || |||  ||. |. .|| |. ..||  |||||||.|.| 
wsllpsglsqpsd..iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1529-1631 7.9e-10 32.6 In-house 218-342 (349) alignment
Range on Protein: 1529-1631
Range on HMM: 218-342/349.0
REVRQFQFTAWPDHGVPEHPTPFLAFLRrVKT-----------CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE----------RIKH-EKTVD-IYGHV
 |. |.|.  |.| ..   |  .|  |  ||             .  .  ...|||||| |||| .. .| .|.          .||   .. | |.  |
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

TLMRAQRNYMVQTEDQYIFIHDALLE
  .| ||  |||   |.|.|..|||.
nelrkqrismvqnlaqfiaiyealLk

fn3 Fibronectin type III domain 830-906 1.2e-09 31.3 Pfam-A 7-84 (85) alignment
Range on Protein: 830-906
Range on HMM: 7-84/85.0
VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPlTTLEFSEKEDH--FTATDIHKGASYVFRLSARNKVGFGEE
 .  .. ... ..| || |  ||..||....  |. .   . ||. ....  .| |..  |..|.||. |.|..| |.|
svsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

I-set Immunoglobulin I-set domain 236-319 4.6e-09 28.0 Pfam-A 1-90 (90) alignment
Range on Protein: 236-319
Range on HMM: 1-90/90.0
PRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNV----LELNDVRQ--SANYTCVAMSTLGVIEAIAQITV
|.|...... |.. | ||...| . |.| | |.|. . ..|...... .  .     |....|..  . .|||.|   .|  || |...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1679-1763 4.9e-09 30.2 In-house 27-116 (347) alignment
Range on Protein: 1679-1763
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-----SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
|.| |..   .  |||  .    ..||| | | .   .       ||||| |     .| || || || .|  |||.|.   . | || .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

Ig_2 Immunoglobulin domain 38-115 6.7e-09 27.7 Pfam-A 14-80 (80) alignment
Range on Protein: 38-115
Range on HMM: 14-80/80.0
GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEviefddgsgsvlRIQPLRTPRDEAIYECVASN-NVGEISVSTRLTV
|    . |||.|.| ||. | |.|...|... .             ..|. .. |  .|.|.||| . .. | |...||
genvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv

subfamily_PTPDC1_pd Subfamily PTPDC1 1848-1915 6.8e-09 30.4 In-house 105-167 (182) alignment
Range on Protein: 1848-1915
Range on HMM: 105-167/182.0
HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVlermrYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .| ..
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvel

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1682-1782 7.1e-09 28.8 In-house 20-88 (169) alignment
Range on Protein: 1682-1782
Range on HMM: 20-88/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWEHNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpek

R
 
e

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1682-1781 9.3e-09 28.3 In-house 19-86 (169) alignment
Range on Protein: 1682-1781
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWEHNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek





0038934 (Phosphotyrosine protein) phosphatases II 1828-1918 9.8e-09 30.6 In-house 85-171 (194) alignment
Range on Protein: 1828-1918
Range on HMM: 85-171/194.0
W--PEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLE-RMryegvvDIFQTVKMLRTQRPAMVQTEDQYQFSYR
.  |..|.. | |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .  . ....|  || .... |...  ..
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1395-1474 2.9e-08 27.6 In-house 32-116 (347) alignment
Range on Protein: 1395-1474
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEG-----IPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
.. | .  |||  .|   | .||.||  .       .   |.|| .|     .. || ||  ||.|  |||.|.   . . || .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_eak_pd Subfamily eak 1553-1637 3e-08 27.4 In-house 225-309 (332) alignment
Range on Protein: 1553-1637
Range on HMM: 225-309/332.0
AFLRRVKTcNPPDAGPmVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
..|.. .   ||   | .. .. |  |.| |.||| ... |   |.    .   .  .. .|.. | .. |. ||....|. .   |
stlkkyih.tppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1385-1440 3.9e-08 27.2 In-house 24-78 (244) alignment
Range on Protein: 1385-1440
Range on HMM: 24-78/244.0
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgIPGSDYVNANYIDGYR
|  ..|    . | .|  |||| |.. .|..||.||. .   ||||.|||||.| .
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1422-1543 5.7e-08 27.1 In-house 7-125 (130) alignment
Range on Protein: 1422-1543
Range on HMM: 7-125/130.0
IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrvkcDQYWPSRGT-E-THGLVQVTLLDTVELATYCVRTFA
.. ..| .|.||...    . . |. ||  | .|  |||.|. |.    .|..  .||      |.|||     |     . ||| |  |        . 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

LYKNGSSEKREVRQFQFTAWPDHG
  ..    .. .  || . ||  |
iesdlneshqaltmfqisnwpsdg

0038934 (Phosphotyrosine protein) phosphatases II 1536-1609 1.9e-07 26.4 In-house 84-156 (194) alignment
Range on Protein: 1536-1609
Range on HMM: 84-156/194.0
FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLeRiKHEKTVDIYGHVTLMR
   .||.|..      | ||. |.. .  |. |  .||| ||.||||....   .  |  . .  . ..... .|
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.r.lgmsaeeAialfrekR

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1395-1492 2.7e-07 23.7 In-house 22-87 (169) alignment
Range on Protein: 1395-1492
Range on HMM: 22-87/169.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAnyidgyrkqnayiatqgslpetfgdfwRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR
..| .|. ||| |  .|  | || |  .    ||||.||                           |||||  .. .|..   ...     ...|| .
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek

Ig_3 Immunoglobulin domain 131-211 3e-07 22.6 Pfam-A 7-75 (75) alignment
Range on Protein: 131-211
Range on HMM: 7-75/75.0
GPQLKVVERTRtATMLCAASGNP-DPEITWFkdflpvdtsnnnGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN
 |.  |.. .   |  | | |.|  | |.|                 . .. | |  .. . | |.   ..| | |.|||.|
spsptvtsggn.vtLtCsaeggpppptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvasN

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1395-1492 3.6e-07 23.2 In-house 21-86 (169) alignment
Range on Protein: 1395-1492
Range on HMM: 21-86/169.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAnyidgyrkqnayiatqgslpetfgdfwRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR
..| .|. ||| |  .|  | || |  .    ||||.||                           |||||  .. .|..   ...     ...|| .
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek

subfamily_PTPDC1_pd Subfamily PTPDC1 1521-1627 5.6e-07 24.2 In-house 73-170 (182) alignment
Range on Protein: 1521-1627
Range on HMM: 73-170/182.0
YKNGSSEKREVRQFQFtAWPDHGVPEhPTPFLAFLRRVKTCnpPDAGPMVVHCSAGVGRTGCFIVIDAMlerikHEKTVDIYGHVTLMRAQRNYMVQTED
|.  .  ....  ..| .|.|.||.   .  |   . |. .   . | . ||| || ||||  |    .     . | ..    ..|.|..|   .|| .
Ydlealmeqgiyvynf.gwkDygvas.leriLdivkvvafa..lqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtre

QYIFIHD
|  ....
qvelvke

subfamily_PRL_pd Subfamily PRL 1847-1908 1.5e-06 22.4 In-house 80-135 (151) alignment
Range on Protein: 1847-1908
Range on HMM: 80-135/151.0
VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEgvvdifQTVKMLRTQRPAMVQ
. |.| .   .  ..||| ||.||. |...|... . |.||      ..|...|..| . . 
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkye......davefirekrrgain

Ig_3 Immunoglobulin domain 26-102 1.7e-06 20.2 Pfam-A 4-75 (75) alignment
Range on Protein: 26-102
Range on HMM: 4-75/75.0
FTRTPVDQTGVSGGvASFICQATGDP-RPKIVWNkkgkKVSNQRFEVIEFDDGSGSVLRIQPLRtPRDEAIYECVASN
 . .|   . ..|.  .. |.|.| |  |.| |     .  .. ..  |  ..|.|.| | .   . |   |.|||||
isvspsptvtsggn.vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvt.sedsGtYtCvasN

Ig_3 Immunoglobulin domain 235-305 2.4e-06 19.6 Pfam-A 1-74 (75) alignment
Range on Protein: 235-305
Range on HMM: 1-74/75.0
PPRFSIPPTNHEIMPGGsVNITCVAVGSP-MPYVKWM-LGAEDLTPEDDMPIGRNVLELN--DVRQSANYTCVAM
.|  |..| ....  |. |..|| |.|.|  | . |.  .   | . ..  .. ..| .   .  .| .||||| 
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas

subfamily_CDC14_pd Subfamily CDC14 1857-1912 4.2e-06 20.8 In-house 263-313 (328) alignment
Range on Protein: 1857-1912
Range on HMM: 263-313/328.0
DGPISVHCSAGVGRTGVFITLSIVlERMRyegvVDIFQTVKMLRTQRPAMVQTEDQ
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  |
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1443-1544 4.8e-06 20.4 In-house 137-235 (244) alignment
Range on Protein: 1443-1544
Range on HMM: 137-235/244.0
NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR-GTETH-GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWP
  || ||  | .|  |||.|. |.    .|..  .||      |.|||     | .   . ||| |  |.       . .  .    .. .  || . ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV
  | 
sdgt

Ig_2 Immunoglobulin domain 242-310 5.1e-06 18.4 Pfam-A 6-71 (80) alignment
Range on Protein: 242-310
Range on HMM: 6-71/80.0
PTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEddmpigRN--VLELNDVRQSANYTCVAMS-TLGV
... ..  | .|..|| | | | | |.| .. | |..       .|   . .  . .| .|||.|    .. 
apptvvtegenvtLtCqapgnptpkvqwykdgeelsqs......qnalfipnvsaedsGtYtCrasnsegsk

PTPc_motif_SM00404 1814-1909 7e-06 21.0 In-house 43-127 (140) alignment
Range on Protein: 1814-1909
Range on HMM: 43-127/140.0
DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQT
  ..... | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||.. ... . ..... .||.. ..
ensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrq.lslaeayefvkerRpiispn