Gene PTPRD in Homo sapiens

Synonym: HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA, PTPRD

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP096_AA protein Get Run
HsapP096_AA_1359-1634 phosphatase_domain Get Run
HsapP096_AA_1646-1925 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1354-1684 9.5e-174 574.1 In-house 2-333 (564) alignment 
Range on Protein: 1354-1684
Range on HMM: 2-333/564.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|||. ||..|...||||..|||..||..|..|||||||..| ..||.||||||..||||||| ||..|| .||||.||..||||||..||||||| |.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLA
||. |||||.|||.|.|.||.|||||...|||..|||..||||.| ..||| ...|||.|..||| | |. |||.||||||.||.||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
..|.|...|.|||||.||||||||||||.||||||||||||.|||||||..|...|.|||.|||||.||||||.|.|||..||||||...||.. .|||.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QIETGENVTGMELEFKRLA-SSKAHTSRFISA
..|.....||.||||.||| ... ....| .|
eveedtemtgleleFqrLatakeieleefava
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1357-1671 1.7e-135 446.2 In-house 2-318 (318) alignment 
Range on Protein: 1357-1671
Range on HMM: 2-318/318.0
IPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|.. .|..|..||... .|..|.||| ...  ...|. .|. .||| ||||||..||||.||.|. .|| .||||.|||||||||...||||.|. ||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
. |||||.||| ||..||.|..|||...|...||||.|....| ..|.| ..|||..| .|.| . .....|.|.|||...|.|||.||||... .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQ
|.|.. . ...|||.|||||||||||| ||..|..|||||.|..||... |. .| ||| ||||||||.||.|.||||...|.||| |..| . |..|..
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

IETGENVTGMELEFKRL
 ..    | |..||.||
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1677-1929 5.2e-129 426.4 In-house 36-286 (564) alignment 
Range on Protein: 1677-1929
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|...||.|....|.|||||||||||||||..|||||||||||||.||||||.||.||...||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||.||||.||.||..|||.|.....|.| .|....|   . ||| |||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH
....|||...|..|||.|.||.||.||.||||||.||.| ..| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1356-1669 1.6e-118 390.5 In-house 4-319 (319) alignment 
Range on Protein: 1356-1669
Range on HMM: 4-319/319.0
PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
.|.. ||......|... . .. .|.. .. ....|..... | ||.|||| |..|||..|| ||...|..||||.||..||||......||||. | .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN-GSSEKREVRQFQFTAWPDHGVPEHPTPFLAF
. |||||.||..| .|||.||| |. .||. .|||.   |. | . |||..  ||. | .| . | |. .  | ||| .||.|.||||.|||. |  |..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
|.|..     ...||.|||||||||||| |||.||||||.|.| ..|..  |  .|.||| |||...||.||..||||||..|.||.  ..|   ...|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QIETGENVTGMELEFK
. ...   ||.| ||.
ekvadtgetglerefq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1662-1931 6.4e-116 381.9 In-house 20-287 (318) alignment 
Range on Protein: 1662-1931
Range on HMM: 20-287/318.0
TGMELEFKRLASSKAHTSRFISaNLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
. .. |..||. |....... | . |.||.||| .||..|..||| ||.. |.||||||||..|||||..|||||.|.||.|| ||||||.|| ||...|
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdGPIS
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||.|||...|.||..|||.|| ...|...||.|.... |. ||| 
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..||||||||.| | . ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_PTPRG_pd Subfamily PTPRG 1357-1647 8e-115 379.2 In-house 1-301 (563) alignment 
Range on Protein: 1357-1647
Range on HMM: 1-301/563.0
IPILELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGS-DYVNANYIDGYRKQNAYIATQGSL
.|. |.| |.  |.|... .||.|.|..      .... |||. . || |||| |..|||.||| || . |. .. ||.||||||||.|..|.|||||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK----NGSS--EKREVRQFQFTAWPDHGVPE
..|| |||||||||..|..||.|.|.|| | |||.|||. ..|| | .|||| ..  ||.| |||. . .    ....  ....|||...| ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY
|..| | | .. .. |. .|||.|||||||||||| .||.|..|..|..|..|...| .  .|||||..||||.||||.|||||||.. ..||. | .. 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

A
.
e
0040438 (Phosphotyrosine protein) phosphatases II 1360-1671 2.2e-111 367.4 In-house 3-314 (317) alignment 
Range on Protein: 1360-1671
Range on HMM: 3-314/317.0
LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF
|.| .....|...|. ....|.| ..  .  |.....|..||.|||| ... |||||| || ..|...|||.||.|.||.......||||| ||.|..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK
|||.|||.. ..||.|.|||..|.||.||||...| |.| ..||||...||| ...||. ....|.||.|.|..|..|.|||||||..|...|.||..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGE
...... ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|..||||| .....| .|| .|. ...||... ...
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

NVTGMELEFKRL
.|...| |.|.|
dvklkekelkll
subfamily_PTPRA_pd Subfamily PTPRA 1352-1668 5.6e-111 365.6 In-house 9-330 (330) alignment 
Range on Protein: 1352-1668
Range on HMM: 9-330/330.0
ASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG
  ..|.|. .| . |.. .|.|| .| .|....     | | | .. | || |||. |.. ||.||| || .||.. |||.|| .||||.... .||.||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS----SEKREVRQFQFTAWPDHGVPE
 . ||  |||||||||.|||.||.|.|.|| . || ||||. |. |.| ..|.. |...|  | || | . . .      ..| |||| ||.||| ||| 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

HPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLY
.|   | .|..||..|.  |||.|||||||||||| |||.||.|||.| |. ||... |  .|.||  ||||. || ||. .|||    |.||. .  | 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

AYIQKLTQIETGENVTGMELEF
 ..||| .  || . .|.| ||
khlqklynkitgtdkigleeef
subfamily_PTPRK_pd Subfamily PTPRK 1354-1669 1.1e-110 364.3 In-house 1-313 (314) alignment 
Range on Protein: 1354-1669
Range on HMM: 1-313/314.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGqqftWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
|| | . .| ..|  ||....  | .||||.  |    |. .. . |. |||. ...|||.||| | .|.| | |||.||..||.|.. .|.|.||| |.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTEtHGLVQVTLLDTVELATYCVRTFALYK--NGSSEKREVRQFQFTAWPDHGVPEHPTPF
||  ||||.......|..||.|.| | .|||| .|||  ..  .| ..|.|..|  || . ||.|...|   | .|.||||||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK
|...||||. ....||..||||||| ||||.||.|| .|. |..|..||..  |  .|...  ||.||.||.||.|..|||. ||.| .|. .. |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LTQIETGENVTGMELEFK
 .....  | . .. ||.
sirldpqtnssqlkeefq
0051299 (Phosphotyrosine protein) phosphatases II 1354-1633 1.1e-107 355.1 In-house 2-286 (288) alignment 
Range on Protein: 1354-1633
Range on HMM: 2-286/288.0
HPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSL
. .|.. ||......|.||.. .. .|.| . . . ..|. ...|. |..|||| ....|||||| || ..|..||||.||.|||||......||||| |
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN----GSSEKREVRQFQFTAWPDHGVPEHP
|.|..|||||.|||.. ..||.|||.|..|.||.||||..|..|.| ..||||....|..|.|||. . ..    |..|.|.|..|..|.|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
...|.|||.|....... ||.||||||||||||.||..| .||....|..||... |  .| ||..||||..||.|...||||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 1355-1635 6.2e-107 352.0 In-house 5-287 (293) alignment 
Range on Protein: 1355-1635
Range on HMM: 5-287/293.0
PPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
 || . ....|....||...|.||.|||..   |.. . . ..|.||. |||| |...|||||| |.|... .||||.|||||.||. .. .||||| ||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHPTPFL
||. |||||.||..| ..||.|.| |. .|||..|||.   . ..| ..|||. . ||  . .|.... |  ..|.|.|||..||.||||||||.....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKTCN--PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
.|.|.|..      ...|.|||||||||||| || .| .|..|..| .|||.| |. .| .||..||||.||||||...|. .. 
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0050432 (Phosphotyrosine protein) phosphatases II 1348-1637 4.9e-106 349.8 In-house 17-303 (308) alignment 
Range on Protein: 1348-1637
Range on HMM: 17-303/308.0
SSSMASHPPIPILELADHIERlkANDNLKFSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaieGiPGSDYVNANYIDGY--RKQNA
 | ..|. ....|.|. ..|.  |.|. ....|.| .   .  .......|. ||.|||| ....|||||| |    . .||||.||.|.|||  .....
tsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprk

YIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR---GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPD
.||||| ||.|..|||||.|||.. ..||.|||.|..|.||.||||.    |....| ..||||.. .|..|.|||. | ..|..| |.|..|..|.|||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

HGVPEHPTPFLAFLRRVKTCNPPdaGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
||||..|...|.||..|....|.  ||.||||||||||||.||..| .||....|..||... |  .| ||..||||..||.|...|||| . .  
hgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0050432 (Phosphotyrosine protein) phosphatases II 1631-1929 4.5e-104 343.3 In-house 10-304 (308) alignment 
Range on Protein: 1631-1929
Range on HMM: 10-304/308.0
EAVTCGNTEVPARNLYAYIQKLTQ-IETGENVTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGvEGSDYINASFIDGY-
|......|.... .|. ....| . .|   . ...| ||..| | |     . .|.||.|| ||| ..|.||...||.|    . |||||||||..||| 
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgys

-RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
 ......||||||| .|.||||||.||.|....|||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.||||..|.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|.||..||| | | ..||. .|.|.     ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||..||.| |||.||||
ytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

GSFDH
 .. .
klklt
0051299 (Phosphotyrosine protein) phosphatases II 1636-1924 5.7e-104 342.8 In-house 1-286 (288) alignment 
Range on Protein: 1636-1924
Range on HMM: 1-286/288.0
GNTEVPARNLYAYIQKLTqietGENVTGMELEFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI
|.||.....|. ...||.      ..||.. ||..| | ...   . .|.||.|. ||| ..|.||...||.|... |||||||||||.||||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQ
|||||| .|.||||||.||.|....|||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.||||..|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||| | | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||..||.| |.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1370-1640 8.3e-104 342.0 In-house 22-297 (298) alignment 
Range on Protein: 1370-1640
Range on HMM: 22-297/298.0
KANDNLKFSQEYESIDPGQQ----FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE
|...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|.....   |||.|| ....|...||.||||. |.||. |||||..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

QRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcNPPD
. ..|.||.|.|||  ..|. .|||..|.||.| ..|.|| . | | . ||.... |. ....|||||..|| |||.||||. |  |..||.|.. .. .
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqq

AG--PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
||  |..|.|||||||.| ||.||..|||.|.|..||..  |  .|..|  .||||.||.||..| |||....|.|.
agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1662-1928 1.5e-101 334.6 In-house 23-287 (319) alignment 
Range on Protein: 1662-1928
Range on HMM: 23-287/319.0
TGMELEFKRLASSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
|..| ||| |  ...    | ||. . || |||  ||..|. ||| |... ||||||||||||||||......||||.||..|.||||||.||..| |||
tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPI
||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.| .||.|.||...||... . .|......|..|.  |.|||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPi

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
 ||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||...||.| | | ||.. ..|
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0043336 (Phosphotyrosine protein) phosphatases II 1356-1631 2e-100 331.1 In-house 1-275 (278) alignment 
Range on Protein: 1356-1631
Range on HMM: 1-275/278.0
PIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
||.. .|......|..|.. ....|.|...  . .|.....|. ||.|||| ....|||||| || ..| ..|||.||.|.|||......||||| ||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPsRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
..|||||.||... |.||.|.|.|..||||.|||| .|..|.| ..||||.. .|..|.|||. . ..|..|.|.|.......||||||||.....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|....... ||..|||||||||||.||... .||....|..||..  |  .| ||  .|||..||.|...||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1636-1931 3.8e-100 330.0 In-house 1-297 (298) alignment 
Range on Protein: 1636-1931
Range on HMM: 1-297/298.0
GNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKA--HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA
||||. |..| | .|||....  ...||..|||.|| | .   ..     |. | || |||  .|....|.|| |. . . | ||||||||...|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
.||||.|| ||.||||||..|.... .||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|.|||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
|.  .  .|.. .|.....| | . |. |.|||||||.| || .. ||||.. | |||.||.||.||..||..||||.|| | | | ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0036941 (Phosphotyrosine protein) phosphatases II 1369-1649 6.5e-99 326.2 In-house 7-293 (297) alignment 
Range on Protein: 1369-1649
Range on HMM: 7-293/297.0
LKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaiEGiPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQR
 |.... ....|.|...| . ........|. |..|||| ....|||.|| |   .. .||||.||.|.|||. ....||||| ||.|..|||||.|||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SATVVMMTKLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVE--LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP
. ..||.|.|.|. |.||.||||.   .. |.| ..||||.. .  |..|..||. ....|..|.|.|..|..| ||||||||.|...|.|...|.....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

P--DAGPMVVHCSAGVGRTGCFIVIDAMLERIK---HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYI
   . ||..|||||||||.|.||..| ||....   .|..|||.  |  .| ||. .|||..||.|...|||| . ...| .|...|. ..
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll
0046845 (Phosphotyrosine protein) phosphatases II 1377-1639 1.6e-98 324.8 In-house 2-280 (284) alignment 
Range on Protein: 1377-1639
Range on HMM: 2-280/284.0
FSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEG-IPGSDYVNANYIDGY-----RKQNAYIATQGSLPETFGDFWRMIWEQR
. .|.| .   . .   ......|. |. |||| ....|||||| |. ..| ...|||.||.|.|||     ......||||| ||.|..|||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATVVMMTKLEERSRVKCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--
. ..||.|.|.|..|.||.||||. | . |.| ..||||.. .  .|.|||. | ..| ..| |.|..|..|.|||||||..|...|.||| |.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK---TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE
|. ||.||||||||||||.||..| .||....|.   .||... |  .| ||..||||..||.|...||||.. ...| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0046845 (Phosphotyrosine protein) phosphatases II 1664-1927 2e-98 324.5 In-house 2-277 (284) alignment 
Range on Protein: 1664-1927
Range on HMM: 2-277/284.0
MELEFKRLASSKAHTS-RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDFWRMLWEHN
.| ||..| | . . .  .  |.||.|. ||| ..|.||...||.|... |  |.|||||||..|||     ...|..||||||| .|.||||||.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF
....||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.||||..|..|.||..||| | | ...|. .|..  |..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG---VVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
...||| |||||||||||.||.| ..||....||   .||....||.||.||| ||||..||.| |.|.|||| ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0040438 (Phosphotyrosine protein) phosphatases II 1660-1924 1.4e-97 322.0 In-house 16-276 (317) alignment 
Range on Protein: 1660-1924
Range on HMM: 16-276/317.0
NVTGMELEFKRLASSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI
..|... ||..| | | .   .  |.||.|| ||| ..|.||...||.|.|. |...|||||||..||.......||||||| .|.||||||.||...|.
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGP
.||||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..||||..|..|.||..|||.| . ..||. .|..  |  ...||
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggp

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||.| |.|.||||
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 1351-1638 2.4e-97 321.2 In-house 8-294 (297) alignment 
Range on Protein: 1351-1638
Range on HMM: 8-294/297.0
MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQfTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYIDGYRK-QNAYIAT
. ...|||.  |. .. ..|||.. .. .|.|..   .   .....|..||.|||| ....|||||| |. ..|  ..|||.||.|.|||.. ....|||
llesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTeTHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHP
|| ||||..|||||.|||.. ..||.|||.|..| ||.||||..|. |.| ..||||.. .|. |.|||. . .  ..| |.|..||.| |||||||...
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

TPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT
. .| ||. |....   |. ||..|||||||||||.||... |||....|..||..  |  .| ||...|||..||.|..||||| . ...|
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0047943 (Phosphotyrosine protein) phosphatases II 1656-1924 5e-97 319.9 In-house 6-272 (273) alignment 
Range on Protein: 1656-1924
Range on HMM: 6-272/273.0
ETGENVTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH
|.  ..|....||..| | |     .  |.||.|| |||  .|.||...||.|    | .||||||||..|||......||||||| .|.||||||.||.
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NSTIVVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE
|....||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.||||..|..|.||..||| | | ...|| .|.|. |
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.. ..||. |||||||||||.||.| ..|.....|| ||....||.||.||| ||||..||.| |.|.||||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1363-1633 2.1e-96 317.4 In-house 9-279 (288) alignment 
Range on Protein: 1363-1633
Range on HMM: 9-279/288.0
ADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR
 ... . .|...  ||.||.|.   ... . . ..| ||..|||| |...||. || |   |  .|.||.||.||||..|...|||||| |..| .|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT
...|... |.||.|.| |. . ||..|||. .. . .| |.|||... ||  . .|.. | |.   ...|. |.|..|||||||||  .|.|..|| ||.
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkv

CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
 |. |.||..||||||||||| ||..||.......|...|. | |. .| ||. .|||. ||.||...||. .
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0047943 (Phosphotyrosine protein) phosphatases II 1370-1632 3.4e-96 317.2 In-house 7-271 (273) alignment 
Range on Protein: 1370-1632
Range on HMM: 7-271/273.0
KANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLsaieGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS
|.... .. .|.| . . . ..|.....|. || |||| ....|||||| |    | .||||.||.|.|||......||||| ||.|..|||||.|||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ATVVMMTKLEERSRVKCDQYWPSRG---TETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP-
 ..||.|.|.|..|.||.||||. |   ..|.| ..||||.. . ..|.|||. |...|..|.|.|..|..| |||||||......| |.. |....   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
 . ||.||||||||||||.||..| .|.....|..||..  | |.| || .||||..||.|...|||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 1351-1633 8.5e-96 316.5 In-house 3-304 (307) alignment 
Range on Protein: 1351-1633
Range on HMM: 3-304/307.0
MASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYI--------DG
.  ...|..| |  .. .|..... .. .|.|.. . . |   ......|..||.|||| ....|||.|| || ..|  ..|||.||.|.        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE-THGLVQVTLLDTVELATYCVRTFALYKN-GSSEKREVRQFQF
|......||||| ||||. |||||.|||.. ..||.|.|.|. |.||.||||. |.| |.| ..||||.. .|. |.|||. .  . |..| |.|..|..
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TAWPDHGVPEHPTPFLAFLRRVKTCNPP--DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|.|||||||... ..|.|...|....    . ||..|||||||||||.||... ||.....|.|   ||..  | |.|.||  .||...||.|...||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

AV
 .
ll
0039614 (Phosphotyrosine protein) phosphatases II 1654-1927 1.2e-95 315.6 In-house 24-292 (297) alignment 
Range on Protein: 1654-1927
Range on HMM: 24-292/297.0
QIETGENVTGMELEFKRLASSKAHtsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRM
..|.  . |...|||..| | |     .  |.||.|| ||| ..|.||...||.|.|..|| ..|||||||..|||.. ....||||||| ||.||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEHNSTIVVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTK
.||...|..|||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.||||..||.|.||. ||| | | ...|. .|..  
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

EQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
.. ...||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||.| |.|.||.|  .
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1647-1924 4.3e-95 314.2 In-house 12-304 (307) alignment 
Range on Protein: 1647-1924
Range on HMM: 12-304/307.0
AYIQKLTQIETGENVTGMELEFKRLASSKAH-TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFI--------DGYRQQKAYIA
 .. .| .... ...||.. ||..| | . .    . .|.||.|| ||| ..|.||..|||.|... |  |.|||||||..        |||......||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVP
||||| || |||||||||...|..||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.||||..|..|.||..|||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

KSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||...||.| |.|.||.|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 1661-1927 6.4e-95 313.1 In-house 12-280 (297) alignment 
Range on Protein: 1661-1927
Range on HMM: 12-280/297.0
VTGMELEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
 .... ||..| . ..    .  |.||.|. |||  .|.||..|||.|    . |||||||||..|||......||||||| .|.||||||.||.|.|..
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
||||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.||||..|..|.||. ||| | . ..||| .|.|  ... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPISVHCSAGVGRTGVFITLSIVLERMR---YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF
.||. |||||||||.|.||.. ..|....   .|| |||...||.||.||| .|||..||.| |.| ||.| ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0043336 (Phosphotyrosine protein) phosphatases II 1660-1924 8.8e-95 312.6 In-house 18-277 (278) alignment 
Range on Protein: 1660-1924
Range on HMM: 18-277/278.0
NVTGMELEFKRLASSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTI
. |...|||..| | |     .  |.||.|| ||| ..|.||...||.|... |...|||||||..|||......||||||| ||.||||||.||...|.
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VVMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGP
.||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.||||.......||..||| | . ..||. .|..  |   ..||
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. |||||||||||.||.| ..||....|| ||....||.||.||| .|||..||.| |.|.||||
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1667-1923 1.7e-94 311.4 In-house 37-294 (330) alignment 
Range on Protein: 1667-1923
Range on HMM: 37-294/330.0
EFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL
||. | ... . . .  |.   || |||.|||.||. .|| |....||| ||||||||||||.... .||.|||..|| ||||||.||..|. .||||.|
efnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdgPISV
.|  .|||.|||| | .  |    |    |  . .| .|.| |..     |. .|| |||| || ||. |||  . | .... .|.|...| ..  || |
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivv

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
|||||||||| ||.|. ||||.. |..||.|..|| ||.||| ||||. ||.| |.. |||
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1357-1653 1e-93 308.8 In-house 4-303 (305) alignment 
Range on Protein: 1357-1653
Range on HMM: 4-303/305.0
IPILELADHIERLKANDNLKFSQEYESIDPGqQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF
| . .|| .|.  ..... .. ..|.|.    . . .  . |.|| |||..... .|..|. |.. |  . |||.||.|.|||.....||..|| |..| 
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

GDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYK-NGSSEKREVRQFQFTAWPDHGVPEHPTPFLA
 ||||.|.| .  |.||.||| |  . || |||| . ||   .| ..|.| .. . . |  | . . . ....|.| | |.|.| |||||||. .| .| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FLRRVKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKL
...||.     | | |..||||||||||| ||..| .|||.|.|..||... .  .| .| .|||| ||| |.|||| | .|||.|..   || | ..||
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

T
 
k
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1353-1646 2.8e-92 304.0 In-house 2-291 (315) alignment 
Range on Protein: 1353-1646
Range on HMM: 2-291/315.0
SHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSL
.| |||. .|  .. . ||. .  | |.||||  || .  . ..   || |||| |.||||.||| |  .|  |.|||||||.|||| |.. |||.|| .
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTETHGLVQVTLLDTVELATYCVRTFALYKngSSEKREVRQFQFTAWPDHGVPEHPTPFL
... .||||...|.  ...||.|.| |. . |...||| .   ..| . ||. .      |.|||..      .. ||| |...|.||| |||.. .|..
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplm

AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVpARNLY
 . |.||  .  ..|..|||||||||||| || .||.|.... |. .|.|  .| .|..|  |||. .|| ||.|||||.. ||.| . |..||
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdly
DSPc_SM00195 1666-1924 1.4e-91 301.8 In-house 4-262 (263) alignment 
Range on Protein: 1666-1924
Range on HMM: 4-262/263.0
LEFKRLASSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||..||.| |.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1666-1924 1.4e-91 301.8 In-house 4-262 (263) alignment 
Range on Protein: 1666-1924
Range on HMM: 4-262/263.0
LEFKRLASSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||..||.| |.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
DSPc_SM00195 1377-1633 4.7e-91 300.1 In-house 2-262 (263) alignment 
Range on Protein: 1377-1633
Range on HMM: 2-262/263.0
FSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT
...|.|...  . . . .... . || |||| |.. |||.|| |. .|. .||||.|||||.|..|...|||||| ||.|. |||||.||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELA-TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
. ||. . |||.|||.   |.||.| ..|.| .. .    . .||. | |.| .|.|.|.|.|...|||||||......|..|| ||...    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||||||||.|..|| .|.....||.|||   |. .| ||  ||||..||.||..|.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1377-1633 4.7e-91 300.1 In-house 2-262 (263) alignment 
Range on Protein: 1377-1633
Range on HMM: 2-262/263.0
FSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMT
...|.|...  . . . .... . || |||| |.. |||.|| |. .|. .||||.|||||.|..|...|||||| ||.|. |||||.||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELA-TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
. ||. . |||.|||.   |.||.| ..|.| .. .    . .||. | |.| .|.|.|.|.|...|||||||......|..|| ||...    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||||||||.|..|| .|.....||.|||   |. .| ||  ||||..||.||..|.||..
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 1682-1924 8.5e-91 299.2 In-house 4-246 (249) alignment 
Range on Protein: 1682-1924
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||...||.|....|...|||||||.||||......||||||| ||.|||||||||...|..||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.||||...|.||||..|||.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|....|. ||....||.||.||| .||...||.| |.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1399-1635 3.6e-90 296.6 In-house 8-244 (250) alignment 
Range on Protein: 1399-1635
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVkCDQYWPSRGTETHG
 || |||||..||.|.|||.|   .|   |||.|| ...||....|.||||| |..|. |||||..|. |.|.||.|.|.|  .. . ||||  ..|..|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK
 |.|.||.. | | | .|.. | |.  ...| |||..|..||| ||||. |  |..|..|.. ..  ...|..|.|||||||.|.||.|||.|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
.||..  .  .|..|  .|....||.|.. ..|.|...
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPRB_pd Subfamily PTPRB 1659-1924 1.6e-89 294.8 In-house 22-285 (293) alignment 
Range on Protein: 1659-1924
Range on HMM: 22-285/293.0
ENVTGMELEFKRLASSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
.. ...  |...| . . .     .|.|..|. |||  ||.||. .|| |..... .|||||||..|.||.... .||||||| ||..|||||.||..|.
dsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkss

IVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD
|.||||.| | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|.|||..|| ||. |||.. . ..||. .|....|.  ..
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|| |||||||||||.||.|  .|.... | .|||| .|  ||..|  .||||.|| | ... |..|
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1356-1653 2.2e-89 294.9 In-house 15-311 (319) alignment 
Range on Protein: 1356-1653
Range on HMM: 15-311/319.0
PIPILELADHIERLKANDNLKFSQEYESI--DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|.  .   . .   .|  |.  |.  .   . .  . ...||. || |||. |..|.|...| |  ..|. .|||.|| ...||.... |||.|| |.
dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPld

ETFGDFWRMIWEQRSATVVMMTkleersRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFL
.|  ||||||||....|.|..|      . || |||| .. ....  .| .    | | | || . | ..|   ..|...|| |  |||.|||..|....
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlm

AFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ
 ....|.  .    .  ..|||||||||||| .||.|..|.|.|.|| ||.|  |  .| ||| .||   || ||. ||||    |...|   .. ||..
rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle

KLT
.|.
els
0040439 (Phosphotyrosine protein) phosphatases II 1391-1633 5.7e-89 293.2 In-house 2-246 (249) alignment 
Range on Protein: 1391-1633
Range on HMM: 2-246/249.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP
......|..||.|||| ....|||||| || ..| ..|||.||.|||||. ....||||| ||||..|||||.||... ..||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDA
..|. ..| ..||||.. ... |.|||. |.... .|.|.|...|.| |||||||... ..|.|...|....   |. ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|||....|..||..  | |.| ||...||...||.|...|||| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1362-1633 7.3e-89 292.6 In-house 2-276 (281) alignment 
Range on Protein: 1362-1633
Range on HMM: 2-276/281.0
LADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFW
|  |...|..|||  | .|||..   |.. | . |. . |. |||| |..|||..|| ..  |    .||.|||...||.....|||||| .|... .||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRTFALyKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVK
.|.|||.  ..||.|.  | ...|| .|||    . . | |.|. . . | |||  |.| | .. |.|.|||.|...|||||||||. .. .| | . |.
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

TCNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
 .. ..   |.|.||||||||||..| .| .......| ...|.   |. .| .||.||||  || |.. |.|.|.
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0042113 (Phosphotyrosine protein) phosphatases II 1393-1631 1.8e-88 291.3 In-house 2-241 (245) alignment 
Range on Protein: 1393-1631
Range on HMM: 2-241/245.0
EHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR
....|..||.|||| ....|||.|| || ..| ..|||.||.|.||||  . .||||| ||||..|||||.||... |.||.|..||..||||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP-PDAGPMVVHCSAGVGRTGCFIVIDAMLE
.. |.| ..||||..  |..|.|||. . ..|..|.|||...... |||||||...  .| ||..|...   .. ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
....|..|...  |  .| ||  .|||..||.|...||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 1659-1926 2.4e-88 291.7 In-house 16-289 (563) alignment 
Range on Protein: 1659-1926
Range on HMM: 16-289/563.0
ENVTGMELEFKRLASSKAHT-SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS-DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN
.. .|.. ||. | |  ...     ... |.|| ||| .||..|...|| |.|. |.... |||||..||||...||.|||||||..|..|||||.||.|
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT
..|.||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ..|||...|.||..|||..    . |. .  ..
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

KEQfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
...  . ||| |||||||||||..| |. .|.... | .|..|...|..|.||. .||||.||.| . | || . |
nka..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0045098 (Phosphotyrosine protein) phosphatases II 1379-1636 2e-87 288.4 In-house 12-275 (278) alignment 
Range on Protein: 1379-1636
Range on HMM: 12-275/278.0
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLlsaiegipgsDYVNANYIDGYrkQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
. .. . .|.  ........ |..|||| ....||||||           ||.||.|||||  ....||||| ||.|. |||||.||... ..||.|.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKN----GSSEKREVRQFQFTAWPDHGVPEHP--TPFLAFLRRVKTCNP---------
|..|.||.||||..|..|.| ..||||.. .| .|..||. ..       . |.|.|...... |||||||..|  ..|| .|.... ..          
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

----PDAGPMVVHCSAGVGRTGCFIVIDAMLERIkhEKTVDIYGHVTLMRAQRNY-MVQTEDQYIFIHDALLEAVTCG
    .. ||..|||||||||||...... |||..  |..||..  |. .| ||.. .||...||.|....||| . .|
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1391-1653 2e-87 288.3 In-house 16-275 (284) alignment 
Range on Protein: 1391-1653
Range on HMM: 16-275/284.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTkleersRVKCDQYWP
. ...||. || |||. ...|.|...| |  . |. .|||.|| .| ||.... |||||| |..|  ||||||||....|.|..|      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVID
 .. ....  .| .    | . | || . | ..|   ..|..||| |  |||.|||..|.........|.  .    .  ..|||||||||||| .||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
..|.|.|.|| ||.|  |  .| ||| .||   || ||. ||||    |...|   .. ||...|.
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
Y_phosphatase Protein-tyrosine phosphatase 1400-1631 3e-87 287.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 1400-1631
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVLLsaiEGIPG-SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP--SRGTET
|| |||| ....||..|| |   .| .| |||.||||..||......||||| |..|..|||||.|.... ..||.|.|||..|.||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGLVQVTLL-DTV-ELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI
.| ..|.|  ..  . . |..|.. | |.... |||||.|...|.||||||||.|...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|..||..  |  .|.||. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1400-1631 3e-87 287.3 In-house 1-235 (235) alignment 
Range on Protein: 1400-1631
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVLLsaiEGIPG-SDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP--SRGTET
|| |||| ....||..|| |   .| .| |||.||||..||......||||| |..|..|||||.|.... ..||.|.|||..|.||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGLVQVTLL-DTV-ELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI
.| ..|.|  ..  . . |..|.. | |.... |||||.|...|.||||||||.|...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
..|..||..  |  .|.||. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0045098 (Phosphotyrosine protein) phosphatases II 1677-1925 4.3e-87 287.3 In-house 21-273 (278) alignment 
Range on Protein: 1677-1925
Range on HMM: 21-273/278.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVClqpirgvegsDYINASFIDGYrqQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
. |..  |....|. ||| ..|.||...||.          ||||||.||||  .|..||||||| .|..||||||||...|..||||.| |.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQDGP
||| . | .|  |.|  . |.... |.|| ..||.      |..||.|...... ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ISVHCSAGVGRTGVFITLSIVLERMryEGVVDIFQTVKMLRTQRPA-MVQTEDQYQFSYRAALEYLG
. |||||||||||... . ..||..  ||.||....||.||.|||  .||...||.| |...||.| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1659-1928 6.8e-87 286.4 In-house 19-287 (305) alignment 
Range on Protein: 1659-1928
Range on HMM: 19-287/305.0
ENVTGMELEFKRLASSkaHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
.. .|.| ..| |..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .| .||||...|   .
ysdkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

IVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfG
 .||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||| |.|.||||..|||..   ....| .|.|.... .
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.d

QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
.. |. ||||||||||||||...| |||.. |.|||.|. .| ||..|. |||| |||.| . |  |.. ..|
kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN9_pd Subfamily PTPN9 1649-1924 2.3e-86 284.5 In-house 3-290 (297) alignment 
Range on Protein: 1649-1924
Range on HMM: 3-290/297.0
IQKLTQIETGENVTGMELEFKRLASsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
|..| .    ..  |.  |.. . . .. . .|  ..|..|  |||  ... |..||| |. . . | ||||||.|.|||.|.||.||||||| .|..||
ieelvayvkekgkrGlskeyaeirn.epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
|||.||..  ..|| |.. |.|| || ||||   | ||..  . |  .   .. .|  | ..........||.|  |||. ||. |||.|.. ..|.. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
| ... ..            .. || ||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||..||.| | | ||| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0042113 (Phosphotyrosine protein) phosphatases II 1684-1924 4e-86 283.7 In-house 4-243 (245) alignment 
Range on Protein: 1684-1924
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||..|||.|.|. | ..|||||||..||||. . .|||||||.||.|||||||||...|..||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.|.......||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
...|. |.....||.|| ||| .|||..||.| |.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 1371-1631 5.2e-86 283.3 In-house 12-288 (297) alignment 
Range on Protein: 1371-1631
Range on HMM: 12-288/297.0
ANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA
....   |.||. |     . | ..|.| .|  ||||..|. ||..|| |. ... . |||.|||..|||....|.|||||.|..|. |||||.|||.  
ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

TVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC------
..||.|...|| |.|| ||||  .  .. .| ..|. ....|   | ||.. ...   .|.|.|  |||..|||.|||.  . .| .|. |.        
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

-------NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
        .|.  |.|||||||.|||| || .|  |.|.... |||.   | |.|.|| ...||..|| | . |.||
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1648-1923 7.7e-86 283.3 In-house 20-291 (319) alignment 
Range on Protein: 1648-1923
Range on HMM: 20-291/319.0
YIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED
| |. .. .  ...| .| ||.|..   .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .| .|
yqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntlad

FWRMLWEHNSTIVVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
||||.||.|.. .|.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | ..|| |  ||..|||...  .. .. .
fWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE-Y
|.. ...  .  .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||.| | | || .
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Ptp69D_pd Subfamily Ptp69D 1355-1652 1.2e-85 282.4 In-house 2-305 (307) alignment 
Range on Protein: 1355-1652
Range on HMM: 2-305/307.0
PPIPILELADHIERLKANDNLKFSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLP
..|.|..|.. ..  | . .  . .|||..     . . . |. . |. |||| ...|.|. || |. |.|   |||.||..| ||.... .|| |. . 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG-----SSEKREVRQFQFTAWPDHGVPEHP
.| |||||||.|| . ..||...|.| .| ||..|||   .  .| . |.| .. .   |  |.. . |..       ..|.| |...|.|.|  |||..
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAY
.  | ....|.  .  . .|.||||||||||.| |. .| .|...| |..|||.  |  .| ||| .||  .||.|.. |||.  . |.|..  ..|   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKL
|..|
ierl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1685-1931 5.9e-85 279.5 In-house 5-249 (250) alignment 
Range on Protein: 1685-1931
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|....|.|| |.. .| . ||||||||..||...||.||||||| .|.||||||..|..|. .||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|.|||..|. ||..|||.  .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
. | |||.|. .|.||..|| .|....|| | |...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
Y_phosphatase Protein-tyrosine phosphatase 1689-1922 6.4e-84 276.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 1689-1922
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
... |. ||..|.||.||.||| |||...||.| |.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1689-1922 6.4e-84 276.4 In-house 1-235 (235) alignment 
Range on Protein: 1689-1922
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
... |. ||..|.||.||.||| |||...||.| |.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Ptp69D_pd Subfamily Ptp69D 1661-1924 8e-84 276.3 In-house 21-286 (307) alignment 
Range on Protein: 1661-1924
Range on HMM: 21-286/307.0
VTGMELEFKRLASSKAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
  |.. |...| ... . |    ..   |..|||  .|.....||| |..| | | ||||||||| ||...| .|| |.|. .| .|||||..| ..|..
dfglakeyekLeareidkst.kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFg
|||..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| | |...| |..  ||.. .| ...| ||.. ...  
vmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.

qDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .|| |||||||||.|.|..|...|.... |  ||||.||| || ||. .||  .||.| ||| |.| 
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN6_pd Subfamily PTPN6 1372-1632 1e-83 275.9 In-house 23-296 (306) alignment 
Range on Protein: 1372-1632
Range on HMM: 23-296/306.0
NDNLKFSQEYESI---DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSaIEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQ
 ..  |..|.|..   .  .... ....   || |||| |.. .||.|| |.  ...|||||.|||||..    ....||||||.|..|  |||||.|..
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

RSATVVMMTKLEERSRVKCDQYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC---
 |  .||.||  ||.. || .|||.  . |..| ..|| ..  .||.| .|.. .  |. ..|.|||.|..|..|||||||..|  .|.||. |..    
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

-NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK---TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
 .  .|||.|||||||.|||| |||||..|. |....    .||.  | ..|.||. .||||.|| |.. |. . 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1655-1921 1.3e-83 275.4 In-house 14-276 (288) alignment 
Range on Protein: 1655-1921
Range on HMM: 14-276/288.0
IETGENVTGMELEFKRLASSKAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE
.   .| ||.. |.. ||. . . |    ..|. |. |||  ||.||. .|| |.    ..|.||||||.|||....|.|||||||||.| .|||.. .|
kksarnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

HNSTIVVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.... .||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ... |.|.. ||..|||.| . ..... ||. ....
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

FgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL
    ||| |||||||||||.||.|  ...... | ..|.. ||. || ||. .|||. ||.| |.. |
d..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN6_pd Subfamily PTPN6 1641-1924 1.5e-83 275.3 In-house 5-297 (306) alignment 
Range on Protein: 1641-1924
Range on HMM: 5-297/306.0
PARNLYAYIQKLTQIETGENVTGMELEFKRLASS--KAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGY--RQQKAYIA
 |...   ...|.. |.  . .|.| ||..|  .  |   ||   .. | || |||  ||.|.. ||| |.   .| |||||||..|..    ..|.|||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyia

TQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTVRQFQFTDWPEQGVP
||| | .| .|||||.|. ||...||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|.|.|..|..||..|||
tqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvp

KSGEGFIDFIGQVHKTKEQFG--QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|. . ..||. .|.. .|..   . ||| ||||||.|||| || . |.|. ....|.   .|| ..||..|.||  .||||.||.| |.|  .|.
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPRK_pd Subfamily PTPRK 1688-1922 9.8e-83 272.6 In-house 42-275 (314) alignment 
Range on Protein: 1688-1922
Range on HMM: 42-275/314.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSArYQ
 |. |||  .|..|. .|| |..| |   ||||||..||.|.. .|.|.||||| ||..||||.....|.. .||||.| | || || .||| . .  |.
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

YFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFITLSIVLERMR
 . |  .      ... | |.|. .     . |.||||||. ||. .||.| .|..... .|.|..|.  ..|.| |||||| ||||.||...|||. ..
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 |||||.|..|| ||.... ||.||.||.| | ..||
regvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1665-1923 1.8e-82 272.0 In-house 1-255 (284) alignment 
Range on Protein: 1665-1923
Range on HMM: 1-255/284.0
ELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT
| ||.|..   . ..    |||. || |||...|.... ..| |... |.|.||||||||| ||.... |||||||| .| .|||||.||.|.. .|.||
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

klremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH
      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |..||| |  ||..|||...  .. .. .|.. ...  .  .| ||
......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE-Y
||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||.| | | || .
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1356-1670 2e-80 265.0 In-house 2-314 (315) alignment 
Range on Protein: 1356-1670
Range on HMM: 2-314/315.0
PIPILELADHIErlKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|||. ..   ..  |      ||.|.  .   . .    .  ..| .|||| |.. .|..|| |  |. .| |||.|| || .. ...||||.|| |. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFaLYKNgSSEKREVRQFQFTAWPDHGVPEHPTPFLA
  |||||..... .|.||.||..|  ..|| |||| | ..    | ..|.||..   .   .| .   .. | |.| | ||||| |||.||... . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk.seesrtvtqfqftewPdkGvdkqtssllk

FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT
... ||. | ..  ...||||||||||| .| || ....||....||..  |. .||.| |.||||..| ||.||.|| .   || ..  ..  ..| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QIETGENVTGMELEFKR
    |.  . |  ||..
tsvdgsgrskmtkefet
subfamily_PTPN12_pd Subfamily PTPN12 1680-1924 6.4e-80 263.1 In-house 31-277 (290) alignment 
Range on Protein: 1680-1924
Range on HMM: 31-277/290.0
RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP
.  ... . |. |||  .|.||. .|| |. |...||||||||.|| |  ....|||.||||..| .|||||.||.| .||||. .. |.|. ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

AE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
 |  .. ... | |. ..| ..  ....| .||.    ..||.|.||..|.||..|||.| .  ...| .|....|   .| |. |||||||||||. |.
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
. .| | .. | .   .|.|. |  ||.||.|.|||..||.. |.| .|..
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1659-1930 8.1e-80 262.8 In-house 17-289 (290) alignment 
Range on Protein: 1659-1930
Range on HMM: 17-289/290.0
ENVTGMELEFKRLASSKAHTSrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN
.. .|.. .||.| |.. . .    .. . || .||  ||..|.  |. |.|| | .    .||||..|.||...|.|||||||. .|  |||...|...
kgnegfrnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG
.||.||||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |....| |.|.| |...|  .  .. .  | .. ||. . |
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

qDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
 ...| ||||..|||..||... . ..... |||.|.|| .| .|.|.| .|||..|||. ..  |.|| ||. |
.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1375-1673 1.7e-79 262.3 In-house 18-316 (515) alignment 
Range on Protein: 1375-1673
Range on HMM: 18-316/515.0
LKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
  ||.|.  .   . .    .. |.| .|||| |.. || .|| |  |.  | |||.|| || ..  ..||||.|| .. .  ||||...... .|..|.
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKLEERSRVKCDQYWPSRGTE--THGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH
|||.|  ..|| .||| . ..    | ..| |. .   .    |.. . |.     | | ||.|| |||.|||.| . .| ... ||. .   . |...|
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih

CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA
||||||||| .| || .. ..|  ..||..  || .|..| |.|||..|| ||..|.|| .   || .|   .  ..| |     |.  . |  ||. | 
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

S
|
s
0037934 (Phosphotyrosine protein) phosphatases II 1392-1631 4.3e-79 260.7 In-house 2-240 (243) alignment 
Range on Protein: 1392-1631
Range on HMM: 2-240/243.0
WEHSNLEVNKPKNRYANVIAYDHSRVLLsaiegiPGSDYVNANYIDGYRKqnaYIATQGSLPETFGD----FWRMIWEQRSATVVMMTKLEERSRVKCDQ
. ...|..|..|||| ....|||||| |      .||||.|||.|.....   .||||| ||||. |    ||||.||... ..||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsrGTETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--------NPPDAGPMVVHCSAGVG
|||  |..|.| ..||||.. .|. |.|||. |.  . . ..|.|.......|||||||..|...|.||. |...        . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERIkhekTVDIYGHVTLMRAQRNY-MVQTEDQYIFIHDALLE
|||..|... ||...    .||..  | |.|.||.. .|||..||.|...||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1357-1655 1.2e-77 256.2 In-house 5-310 (325) alignment 
Range on Protein: 1357-1655
Range on HMM: 5-310/325.0
IPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETF
| ...| .|.|. ||.|.  |..|.. . . .  . . . .  || |||. ||.|.|.||| | . .  | |||.||.|.  ..|.. ..|.|  |..| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMIWEQRSATVVMMTKLeERSRVKCDQYWPSR--GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAF
.|.||.. . |.. ||.. .| .    .| .||| .   . | | ..| |    |.. |  | . . .    | | |.|||. .|.| ||...|. ....
ndlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKT------CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAY
|. ||.      .|   ..|..||||||||||| || . ..|... .|  |||.| |  .|..|  ||.| ||||.|..|| ||. .|||.||  .. | 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLTQI
.  | . 
lsslqer
0037934 (Phosphotyrosine protein) phosphatases II 1683-1924 1.9e-77 255.4 In-house 4-242 (243) alignment 
Range on Protein: 1683-1924
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYESTRVCLqpirgvEGSDYINASFIDGYRQqkaYIATQGPLAETTED----FWRMLWEHNSTIVVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||..|.....   .||||||| ||.||    |||||||...|..||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQDGPISVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|.|...... ||..||| | | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDIFQTVKMLRTQRPA-MVQTEDQYQFSYRAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||..||.| |.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1398-1632 2.6e-77 254.2 In-house 5-239 (239) alignment 
Range on Protein: 1398-1632
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTET
 ||| ||||||...||||||.|  .   | |||.||.|.  |    .|||||||..  . ||||||.|..| . .||.| | |  . || ||||   |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsk

HGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHE
.  ..|||  |  .| | .||| . . | .|.| | |..|| |||.|||.. |  | . |..   . | | | |.||||||||||.|.|||||| . |..
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
|||||. .|  .| .| .|||| .||.||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1653-1924 2.6e-77 254.7 In-house 6-276 (281) alignment 
Range on Protein: 1653-1924
Range on HMM: 6-276/281.0
TQIETGENVTGMELEFKRLASSK-AHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRM
.. .. .. .|.  |.. ||.    .|..  ... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .. ..||.|
lkqlsqndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

LWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT
.||.. ...||.|.  | |. |||.||| .. . .|  ..|  .|| . ..|| |.||. ....|..|.|.|...| ||..|||.. . ...|  .|.|.
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

KEQFGQdGPISVHCSAGVGRTGVFITLSIVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.|.  .  |. .||||||||||..|.|  .....   .  .|. ..|. || .|  ||||  ||.| |.| |..|
tekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN12_pd Subfamily PTPN12 1388-1633 2.9e-77 254.4 In-house 28-277 (290) alignment 
Range on Protein: 1388-1633
Range on HMM: 28-277/290.0
QQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
.... |... |.|. |||| ... ||.||| || ||. .||||.|||.| |  .. .|||.|| ||.|  ||||||||..   |||. .. |  . ||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPSRGTETH--GLVQVTLLDTVELA-TYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI
|||..| |.   | ..||| .   .   . .||... ..  .|.|.|.||..|||||||||. ... |.... |.. .  .. |.||||||||||||  |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
.|| . | .|.||.   .|..  |. .| ||. .|||..|| ... |..| |
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1397-1631 6.9e-77 252.8 In-house 5-239 (239) alignment 
Range on Protein: 1397-1631
Range on HMM: 5-239/239.0
LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRgTE
  ||| ||||||...||||||.|  .   | |||.||.|.  |    .|||||||..  . ||||||.|..| . .||.| | |  . || ||||   | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.ts

THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH
 .  ..|||  |  .| | .||| . . | .|.| | |..|| |||.|||.. |  | . |..   . | | | |.||||||||||.|.|||||| . |.
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
.|||||. .|  .| .| .|||| .||.||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1357-1637 5.8e-75 246.8 In-house 2-287 (290) alignment 
Range on Protein: 1357-1637
Range on HMM: 2-287/290.0
IPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPG--SDYVNANYIDGYRKQNAYIATQGSLP
||. .......  .|. | .| ......| |. ..| .. . . ||..||.||.. ||  |. |  | | .    .|.|| ||.||.....|||||| ..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHG-VPEHPTPF
.|  |||..||..... .||.|.  |  .||| ||||...|.. | ....||.  .| .|  |.. . .. |  .|..| |.|.|.|...| |... |  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
|.. ...||   .  ...|||||..|||.. |....  ... | |  .|..  .  .| |.  .|||..|| .|.. .|..... .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN13_pd Subfamily PTPN13 1391-1634 1.5e-74 245.7 In-house 28-270 (273) alignment 
Range on Protein: 1391-1634
Range on HMM: 28-270/273.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsdYVNANYIDGYRKQ--NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQY
| | .. . || |||| ||. ||..|| |..  |     |.||..|     .    |||.|| ||||  |||.|.|||..  ..|.|.  |. .|||..|
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPSRGTETH---GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPpDAGPMVVHCSAGVGRTGCFIV
||..  ..    . ..|.||....| .. ||..|. .. |.| ||| ...|..||||||| .....| |...|.. .  ||||.|||||||.||.| .|.
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlit

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
||..|. |...| .|.   |  .| ||. .|||.|||||.. |.||...
idvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1355-1643 3.7e-74 244.5 In-house 8-294 (297) alignment 
Range on Protein: 1355-1643
Range on HMM: 8-294/297.0
PPIPILELADHIERLKANDnlKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKqnAYIATQGSLPE
 |||. ..|  ... .  |   ||.|.  .   . ..   ..  || .|.||.|.. || ||| |  ..  | |||||| .. |...   .|.||   ..
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPE--HPTPFL
|  |||.|..... .|.||.....|| . || .||. .|. | | | |.|| . |   .  |.. . |. .  .| |.|.||. |||. |..  . . .|
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

AFLRRVKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR
 ..  |.      |  |..|||.||||||| .. || .. ..|.||.|||.| |. .| .| |.|||..|| |.. |.|||. . .|...| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1688-1924 1.9e-73 242.3 In-house 42-276 (515) alignment 
Range on Protein: 1688-1924
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||.|.|| |. |     |||.|||.| ..  .|||||.|||.  ...||||.....| | ..|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||| ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
   .||.|..|. .| .|| .|||..|| | | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN3_pd Subfamily PTPN3 1391-1633 2e-73 241.8 In-house 32-275 (280) alignment 
Range on Protein: 1391-1633
Range on HMM: 32-275/280.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYID----GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD
. .....  | .|||| ....||. || |.. |     ||.||||..    .    | |||||| |..|  |||.|.|||.| ..||.| | || |||| 
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPSRGT-ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV
||||. .   ..|  .|..  . |  .|..| . | .. ..|.|.. |.|..||||||||.... || |..||...   .  |.|||||||.|||| .|.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
..  |  | ... | .   |  || ||  .|||..|| |. .|.|.. 
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1658-1931 3.4e-73 241.1 In-house 16-285 (287) alignment 
Range on Protein: 1658-1931
Range on HMM: 16-285/287.0
GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNS
 .. .| .  |. | . . .      .  . || |||| .|....  || |.     |  |||||.|||||...||.|....|...|  .||......| 
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnv

TIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGq
|..|||....|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ..|.|.|.|.|...|  .. .  .  | .  ||. . | 
taivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.

DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA
...| ||||..|||...|.   . ... . |||.|.|| .|  | |.| .||| .||.| . . |||| ||. |.
ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1361-1640 5.7e-73 240.8 In-house 6-286 (439) alignment 
Range on Protein: 1361-1640
Range on HMM: 6-286/439.0
ELADHIERLKANDNLKFSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG
|. .|.|.|. |..  |....|.|.   |  .        | ...|||| .| |.||.|| |  | |.| | |.|||||.|| ... ||||||   ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEQRSATVVMMTKLEERSRvkcdqYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS--SEKREVRQFQFTAWPDHGVPEHPTPFLAFL
||||...|....|.||.|.| |  .     |||| .   .| . |     .||  |..| | ....      .| | ||...||||. || . .  | ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||| | |...| ||. |||.  ||.||..|.|| .  |.. |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1390-1631 6.3e-73 240.2 In-house 18-266 (274) alignment 
Range on Protein: 1390-1631
Range on HMM: 18-266/274.0
FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGI-PGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
|. |. ..  .. |||| ...  ..|||||.. ..  . |.|.||||| ||.. ..||.|||| ||.|  ||||||.....  .||.|||.|. . || .
fdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPSRG----TETHGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP---PDAGPMVVHCSAGVGRT
|.| .     .|..| |...  ..||   | ||.. | .  .  .|.|  . .|.|||| .|......| ... |.. .      ..|.|||||||.|||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|||| |.  . ....|..||. . |. .| .|  ||||..|| .|| || .
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN3_pd Subfamily PTPN3 1667-1919 2.9e-72 237.9 In-house 20-270 (280) alignment 
Range on Protein: 1667-1919
Range on HMM: 20-270/280.0
EFKRLASsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirGVEGsDYINASFI----DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM
.|..|   |        |..| |  |||  .|.||..||| |.     |  |||||...    ..  . . |||||||||.|..|||.|.||..|...||
qfeqlyr.kkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
|| | | || ||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.. |.|...||..|||.. . |..|. .|.|...  |.. |. 
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRA
||||||.|||||.|.| . |  .  .  | . . |...| || ..|||..||.|   |
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1685-1925 9.8e-72 236.3 In-house 24-269 (274) alignment 
Range on Protein: 1685-1925
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .| ||.. .|||.||||||..| .|||||.........||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD-GPISVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|.|  . .||||.. .|.. . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLG
|| . ..| |.|||....|  || .|  ||||..||.. .||  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1357-1640 1.4e-70 232.5 In-house 2-285 (287) alignment 
Range on Protein: 1357-1640
Range on HMM: 2-285/287.0
IPILELADHIERLKANDNLKFSQEYESIDP-GQQF-TWEHSNLEVNKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQNAYIATQGSLPE
||. .... ... .|. |  |.. .  ..  .|.     |.  . ||.|||..... .|  ||||         ||.|| .||||....|.|.... . .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQFTAWPDHG-VPEHPTPFL
|  .||..|....  ..||.....|  . .| ||||.  . . |  ...||.    | | .|.. . ... ...|..|.|.|.|.|...| |.|. | .|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
 . ...||   .  ...|||||..|||.. |. ..  ... | | ..|..  .  .| |.  .||| .||.|| |..|| .....| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1679-1924 3.1e-70 231.5 In-house 34-277 (315) alignment 
Range on Protein: 1679-1924
Range on HMM: 34-277/315.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYW
.|  .|  . |  |||  ||.|..|.|| |. |     |||||||.| .. ..|||||.||||  . .|||||..... | .||.||..|  . || |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFIT
|     |...  . |. .      . . |.. ||  .  .|||| |||||.||..||.|    .. .| .|   ...  .. .. ||||||||||||.|.
PdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.  |..... . .||.|..||.||..|| .||||..| | | | ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1674-1928 3.9e-70 231.3 In-house 36-288 (297) alignment 
Range on Protein: 1674-1928
Range on HMM: 36-288/297.0
SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQqkAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGReK
 .| .     |.   |  |.|  ||.||.| || |. .     |||.||||. |...   .|.|| |  .| .|||.|..... ...|||... |  . |
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.k

CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK--SGEGFIDFIGQVHKTKEQFGQDgPISVHCSAGVGRT
| .||. . .. . . .|  ..  .   .| ||..||  .  . | |.|.||..||.. |..  | . ....| .|.|. .|  .  |. |||.||||||
caryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrt

GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFD
||..|.  |. ... |  ||||..||.|| .|| .|||..||.| | | ||.| | |
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1400-1631 6.1e-69 226.8 In-house 3-237 (237) alignment 
Range on Protein: 1400-1631
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVLLSAIEGipGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG-TETH
|| ||||.|..|||||||.|    .  ||||.||.|..|.    . |||.|| |  .  |||.|.|... . .||.| | |. ..|| .||||    ...
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GLVQVTLLDTVELATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNP--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIK
| . |.|    |.. | ||.. | |...  | | . |.|||.|||.|||.. . .| | ...   .|  ...|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
 .| |||| .|  .  .| |..||.|||.|||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN13_pd Subfamily PTPN13 1667-1926 1.2e-68 226.4 In-house 16-271 (273) alignment 
Range on Protein: 1667-1926
Range on HMM: 16-271/273.0
EFKRLASSKAHTSRFiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSdYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT
||| |   |.  .   ...   || |||  |..||. ||| |.     ||. |||||.|      ..  |||.|||| ||..|||.|.|| ......|.|
efkelrelkpldtce.vgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPIS
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| | ...|..||. |||.| . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|. || || ..|||.||| | |.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPN14_pd Subfamily PTPN14 1666-1924 6e-68 224.0 In-house 27-296 (300) alignment 
Range on Protein: 1666-1924
Range on HMM: 27-296/300.0
LEFKRLASSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVeGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
 |. |..  ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| |      ... ||..||||  | .|||.|.||.. ...|||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TKLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
|. .| |.||...|.| .    ...... | |      . ...| . .|.     .. |||  .|.||||..|||.  .||.... .|.  .... .   
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
    . |. |||||||||||| |.  .... .  . ..|| .....||.||  .|||  ||.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1662-1925 1.2e-67 223.4 In-house 23-289 (325) alignment 
Range on Protein: 1662-1925
Range on HMM: 23-289/325.0
TGMELEFKRLASSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVV
 |.  ||. | |  . .  .  | .| || |||. |..... .||.|.  .    |||||||..  ..... ..|.| ||..|..|.||.. . ....||
dgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv

MLTKLrEMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
.| .| . | ..| .||| |   | ..  . |  ..  ..  |. | ..| ....|..|.|.|||.  |.. ||.|    .| ..  |.. .|.      
vlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLG
  .|| ||||||||||||||.|  .|...  |  ||||. || || .||.||.| ||| . | |  |.. 
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_PTPN1_pd Subfamily PTPN1 1383-1635 3.4e-67 221.2 In-house 14-273 (290) alignment 
Range on Protein: 1383-1635
Range on HMM: 14-273/290.0
SIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERS
 |.   ..|. ....|. |...||| .|  |||||. |   .     ||.||. ..  . .  || ||| ||.| . ||.|.|||.| .|||. |. |..
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

RVKCDQYWPSRGTE-----THGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKT--CNPPDAGPMVVHCS
..|| ||||.   |      .  ..|.|. . .  .| ||.. | .  . | ||. .| .|.||| |||| |. || || .|.   .  .| || |.|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRTGCFIVIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
||.||.| |...|..| .|....    |||  ..  .| .|  ..|| ||  | . |.|| . .
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1687-1924 5.4e-67 220.6 In-house 18-264 (270) alignment 
Range on Protein: 1687-1924
Range on HMM: 18-264/270.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-
  .|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. |...||||.||...| .||.|.| | ||.|| .|||||.   
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-RYQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFI
 ....    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . .|. |||||||||||..|
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.| |... .  .. ||. . .. || .|.|.||. .||.| |.| .|| 
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN23_pd Subfamily PTPN23 1657-1923 8.7e-67 219.9 In-house 10-279 (288) alignment 
Range on Protein: 1657-1923
Range on HMM: 10-279/288.0
TGENVTGMELEFKRLASSKAHTSRFISAN-LPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQ-KAYIATQGPLAETTEDFWRMLWE
. ...|... .|| | ..... .|  |     ..  |||  .|.||...||.|.     .  |||||||. .   .   .||||.||..|  |||.|..|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

HNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK--T
  | ..|||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ..|.  |.| ||| |||.| | ...|...|..  .
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

KEQFGQDGPISVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
..|   . |. |||||||||||||    ..| |  . .|..|| | |. ||.||  |||...|..||| | ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1684-1924 1.7e-66 219.3 In-house 44-279 (315) alignment 
Range on Protein: 1684-1924
Range on HMM: 44-279/315.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAErS
|.   || ||| .||..|. .|| |  .   ..|||.||.||||| ... |||.|||.... .||||...|.. . .||||.| |  ..|. .||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

ARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLER
  |  . |  . |    .|  | . |.   . . |.| |...| ||. ||||.   ....| .|.. ...    |.| ||||||||||| ||||. ||..
viyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
.  | ..|... .. .| .|  |||. .|||| | | || .
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_CG7180_pd Subfamily CG7180 1689-1924 2.3e-65 215.2 In-house 42-290 (296) alignment 
Range on Protein: 1689-1924
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||...|.. ..|.|| |..|  || ..|||.......  ||.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQDGPISVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |.|..||.| |.  . || | ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
... . || .. |. ||.|. ||.|| .|| .|.. ..|.. |   ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1356-1678 6.2e-65 214.1 In-house 3-281 (392) alignment 
Range on Protein: 1356-1678
Range on HMM: 3-281/392.0
PIPILELADHIERLKanDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPET
|||. ..   .|. .   .  |..|.  .   . .    .. |.|..|||| |.. || .|| |  |. || |||.|| ||...  ..||||.||  . .
pipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FGDFWRMIWEQRSATVVMMTKLEERSrvkcdqywpsrgtethglvqvtlldtvelatycvrtfalyknGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
. |||||..... .|..|.|||.|                                               ..| | ||.|| |||..||.| . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI
. ||.     . |...||||||||||  | ||... . |. . ||..  || .| .| |||||..|| ||. |.|| .   || .|   .  ..|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

ETGENVTGMELEFKRLASSKAHT
  |.  . .  ||. | .|.. |
sdGdvrskqlkefrslkashtvt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1372-1647 2.7e-63 208.5 In-house 6-280 (283) alignment 
Range on Protein: 1372-1647
Range on HMM: 6-280/283.0
NDNLKFSQEYESIDPGQQFTWEHSnLEVNKPKNRYANVIAYDHSRVLLSAIEGipgsDYVNANYID---GYRKQNAYIATQGSLPETFGDFWRMIWEQRS
|.|  | . .. .   .. .  .|  . ||.|||. .....|  || | .       ||.|| .|     |.... ||..|. | .|  |||.|..... 
nnnklfrevlkrlsvpdldadias.adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKR-EVRQFQFTAWPDHGvPEHPTPFLAFLRRVKTCNP-PDA
...||.||| |  |.|| ||||.||.| .|   ||| . .   .. .. . | .|.|...   .  .|.  | . | .. .   |  . .|..       
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskk

GPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYA
||.|||||.|.|||. || . | .. .. |  ||..  |. || ||  .||| ||| ..|.. ||   ||.|.. | .|..
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_PTPRN_pd Subfamily PTPRN 1660-1922 7.5e-63 207.0 In-house 27-290 (297) alignment 
Range on Protein: 1660-1922
Range on HMM: 27-290/297.0
NVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI-DGYRQQKAYIATQGPLAETTEDFWRMLWEHNST
| . .| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.| |   .. ||||||||||.|  |||.|.||. ..
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQD
..|.||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||| || |  |||.||| |   ...|  .| |.    |. 
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grs

GPISVHCSAGVGRTGVFITLSIVLERMRyEG--VVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 || ||||.|.|||||.| . .||.|.   |   .||  |.. || ||| .|.|.||..| . |  |
cpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1660-1930 7.5e-63 207.0 In-house 13-299 (301) alignment 
Range on Protein: 1660-1930
Range on HMM: 13-299/301.0
NVTGMELEFKRLASSKAHTSRfISANlPCNKFKNRLVNIMPYESTRVCLQPIRG--VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNS
. ...| ..|.| . . ...  .. .   ||  ||  || .|.  |. |.| .   .   .|||||.||||...|..||.|||. .|  ||||..|..  
hsnkfeeqykelkegedksct.vgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TIVVMLTKLREMGREKCHQYWPAERSARY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTVRQFQFTDWPEQGVPKSGEGF
. .||.|.|.|  ..||.||||  .  ..    | |  . |...|....|...|.  |              .| .|..| |.| ||||..|| .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

IDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
.  | .| ... . |  ||. ||||..|.|.||....|| ||  . |||||.|| .| .| ..| .|.| .|| . | .  .||   . |
Lqviddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_CG7180_pd Subfamily CG7180 1397-1637 1.2e-62 206.2 In-house 39-294 (296) alignment 
Range on Protein: 1397-1637
Range on HMM: 39-294/296.0
LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWPSRGTET
 . |. |||. .|. ||. ||.|. ..|   |||.|| |.|.. |...|| |..   || ..|||..... . .||..||  . .. .. .||| .. | 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

HGLVQVTLLDTVELATYCVRTFALYKN----------GSSEKREVRQFQFTAWPD-HGVPEHPTPFLAFLRRVKTC-----NPPDAGPMVVHCSAGVGRT
.| . | .. . ..|    ||| |.|.           . |.| |..||.| |.  . ||   . .. ..|||..      . |. ||.||..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
| .. ||| || ...|. ||... |  .| .|. .|.. ..| .| | ||||| |. 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 1378-1633 4.3e-62 204.5 In-house 32-292 (297) alignment 
Range on Protein: 1378-1633
Range on HMM: 32-292/297.0
SQEYESIDP--GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI-DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
..|.|..     .. | | .. | |  |||...|..|||||| |..      |||.||  | |   .. ||||||| |..|  |||.|.||| .. .|..
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

TKLEERSRVKCDQYWPSRGTETHGLVQVTLLD-TVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC
|.||| .  .|..|||  |.|.... .| |.   .    | ||.| |    .|| | | || | .||..|||  . ..| | |.|  .    . |.||||
trleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

SAGVGRTGCFIVIDAMLERI-KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|.|.||||..|.|| .|.|. |  | .||   .  .| ||. .|.|.||. |.  |. | |
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1399-1631 2.1e-61 202.3 In-house 19-262 (270) alignment 
Range on Protein: 1399-1631
Range on HMM: 19-262/270.0
VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ-NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE--
 .|  ||||...   ..|| |. .|  . . |.||||. |. .. ..|||..| || |  .|||||||... ..||.|.|||. | ||..|||..  |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--THGLVQVTLLDTVELATYCVRTFALYKNGSseKREVRQFQFTAWPDHGVPEHPT------PFLAFLRRV-KTCNPPD-AGPMVVHCSAGVGRTGCFIV
  ..| ..|. | ..    | ..   | ..|.  .|..  |....|||||||...         |. || | ....  | |.|..|||||||||||..|.
kledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
.| ... ....| ||.   .. .| .|  .||. .|| |.. |..|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1387-1630 2.6e-61 201.9 In-house 25-274 (287) alignment 
Range on Protein: 1387-1630
Range on HMM: 25-274/287.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAiEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD
.  .|.  ..   .  |||||.|. .|..|||||| ||  ||||.||||. .|....|.||.|| .. | .||||...|.|||.|..||.  | .| || 
sstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPSRGTET-HGLVQVTLLDTVE-LATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV-----KTCNPPDAGPMVVHCSAGVGR
.||| |      |   |.|||       |.||.. | .  . | | |.|... .|||....     .. |   |      . .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
.| .. . ....| .    ||.   |  .| .|. .||.  |. .. .|| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1689-1924 2.8e-61 202.3 In-house 48-279 (439) alignment 
Range on Protein: 1689-1924
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| .|.|| ..| |||||||  |||.||||...|.... .||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||| ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|  |||   ||.|| ||  |||.  || | | | || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1664-1923 7e-61 200.5 In-house 12-276 (287) alignment 
Range on Protein: 1664-1923
Range on HMM: 12-276/287.0
MELEFKRLA-SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVM
.. |...|   |.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| |  ||||...|..|. |..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LTKLREMGREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV--HK-TKEQFGQD
.|.  | .| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| |.|... .||..... .  |.| |. .|  |   . .  . 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
||. ||...|.||.|..... ....|.   | ||. ..|  || .| |.||.  |....| |   |
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPN23_pd Subfamily PTPN23 1398-1633 2.1e-60 199.0 In-house 41-280 (288) alignment 
Range on Protein: 1398-1633
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQ-NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG--T
...  |||. ... |||.|| |         ||.|| .. .   .   .||||. |..| .|||.|..||.| ..||... ||. . |.|.|||..   |
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC----NPPDAGPMVVHCSAGVGRTGCFIVIDAML
...| ..||| .. |. |.  |.. |  ........|.  |.|.||..|||. |  .|.||  |...    . .   |.|||||||||||| | .. | .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ERIK-HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
. .. ..  .||   |  .|.|| .|||...|. |  .| |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1684-1923 2.4e-60 198.8 In-house 28-265 (283) alignment 
Range on Protein: 1684-1923
Range on HMM: 28-265/283.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFID---GYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA
|    || |||  .|.|..  || |..       |||||.||     |.|.| ||..|.|| .|  |||.|..... | .||||||.|  |.|| |||| 
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQDGPISVHCSAGVGRTGVFITLSI
. |  |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..| 
rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasa

VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
 .. .. | |||.|..||..| ||. .||| |||.. . ..|| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_PTPN1_pd Subfamily PTPN1 1676-1922 3.6e-60 198.1 In-house 19-269 (290) alignment 
Range on Protein: 1676-1922
Range on HMM: 19-269/290.0
AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH
|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||..|.. ||.|.||..|  |||| |. | .. ||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGR
|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.. .| .| ||. |||.|   |..|. .| ..     . ||  .|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.| |. .  .| ..  ..    ||| ...  || .|  ..|| || .||| | ||
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN14_pd Subfamily PTPN14 1377-1632 4.3e-60 198.2 In-house 25-295 (300) alignment 
Range on Protein: 1377-1632
Range on HMM: 25-295/300.0
FSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIpGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM
  .||| | . ..  . . ..|..|..|||. .|. |...|| ||. .    ..|.||  |      |.  ||..|| |. |  |||.|.|||  . .||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

MTKLEERSRVKCDQYWPSRG----TETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN-------
.|. ||  . |. .|.|. .    | ..|  .||   . .  ..  ... |.   |.|.|.|  .|.| |||||||| ...|| .|..|.          
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

P--PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA
.      |..|||||||||||  |. | ... ..|....||   .. .| || ..|||  || |....|.. 
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
0051429 (Phosphotyrosine protein) phosphatases II 1425-1653 1.7e-57 190.4 In-house 1-244 (272) alignment 
Range on Protein: 1425-1653
Range on HMM: 1-244/272.0
IPGSDYVNANYIDGYRK---QNAYIATQGSLPETFGDFWRMiWEQRSATVVMMTKLEERSRVKCDQYWP------------SRGTETHGLVQVTLLDTVE
.| |.|.||....|| .    .......| || |  ||||. .|..  |.|.....||| |.|||.|||            |  | ..| . |||| .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LATYCVRTFALYKN-GSSEKREVRQFQFTAWPDHGVPEHPtpFLAFLRRVKTcnppdAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVD--------
|  | .|.. |..  . .| |||.....|.|||||||...  .|..|. . .      ||..||||||..|||...... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAvTCGNTEVPARNLYAYIQKLT
... |  .|||| ..||||.||.|...||||.  .. ..|.|. | |... . 
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1372-1639 1.9e-57 189.3 In-house 12-299 (301) alignment 
Range on Protein: 1372-1639
Range on HMM: 12-299/301.0
NDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEG--IPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSA
. . ||...|.... |.. . . .  | ||. ||. |.  ||. |..|.  .   .   .|.||.|||||......||.|| . .|  ||||.||... .
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TVVMMTKLEERSRVKCDQYWPSRG--TETHGLVQVTLLDTVELATYCVRTFAL-YKNGSS--------------EKREVRQFQFTAWPDHGV-PEHPTPF
..||.|.|.|... || ||||.    .|. | ..||| ..  .  . .| ...  ..||.              . ..| |.| | ||..|| .|. |  
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

LAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE
 .    ... . .. ||.|||||..|.|.| .. ..  ||  | |  ||... .  .| ..  .|.| .||..|.|.. . ... .|.
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
0051429 (Phosphotyrosine protein) phosphatases II 1715-1926 4.1e-57 189.1 In-house 2-227 (272) alignment 
Range on Protein: 1715-1926
Range on HMM: 2-227/272.0
EGSDYINASFIDGYRQ---QKAYIATQGPLAETTEDFWRMlWEHNSTIVVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  | .||||. .|.. . .|.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPKSGegFIDFIGQVHKtkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.|.....||||  |||..   ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS
 ....|..|| |||..||||.||.| |.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1683-1924 1.3e-56 186.7 In-house 39-236 (392) alignment 
Range on Protein: 1683-1924
Range on HMM: 39-236/392.0
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGrekchqywpaer
.|. . |. |||  ||.||.|.|| |. |  .  |||.|||.|... ..|||||.||| | . .|||||....| | ..|.|||.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

saryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktKEQFGQDG-PISVHCSAGVGRTGVFITLSIVL
                              .  . ||| ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |.
..............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvv

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 . .   .||.|. |  .| .|| ||||..|| | | | || |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1689-1922 1.8e-56 186.0 In-house 3-237 (237) alignment 
Range on Protein: 1689-1922
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYESTRVCLQPIRGveGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||....|.    | |||.||||  . .|||.|.|. . ...|||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | . |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
 . ||||.. |. .  .|| ..||.||| | ... ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1688-1922 6.1e-56 184.2 In-house 6-238 (239) alignment 
Range on Protein: 1688-1922
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|.    ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.  ||||. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1688-1922 8.1e-56 183.8 In-house 7-239 (239) alignment 
Range on Protein: 1688-1922
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|.    ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
.  ||||. || .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0041856 (Phosphotyrosine protein) phosphatases II 1400-1640 4.1e-55 181.5 In-house 1-178 (182) alignment 
Range on Protein: 1400-1640
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRvllsaiegipGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTkleersrvkCDQYWPsrgtethgl
|..|||| ... |||||          ..||.|||...|..... .||||| |..|. ||.||..|..  |.|..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

vqvtlldtvelatycvrtfalykngSSEKREVRQFQFTAWPDHGVPEhPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVIDAMLERikhekTV
                         . ..|.. |.... |||||||. .  .|.|...|.     . || .|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEV
...  | |.| .|. ||.|..||.|...|||| . ...|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
0041856 (Phosphotyrosine protein) phosphatases II 1689-1924 5.6e-53 174.5 In-house 1-171 (182) alignment 
Range on Protein: 1689-1924
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYESTRvclqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| .|..||.|||.|.. |..|.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTVRQFQFTDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 |.....||..| .|| ||.|..||.| ..|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
0036282 (Phosphotyrosine protein) phosphatases II 1716-1915 4.2e-52 171.6 In-house 1-161 (174) alignment 
Range on Protein: 1716-1915
Range on HMM: 1-161/174.0
GSDYINASFIDGYRQQKAYIATQGPLAettedFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||..|...  . .||.|||||     ||.||.|...|.||||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTVRQFQFTDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRyEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..||....|..||.||| ||||..||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
0036282 (Phosphotyrosine protein) phosphatases II 1427-1627 1.4e-51 169.9 In-house 1-164 (174) alignment 
Range on Protein: 1427-1627
Range on HMM: 1-164/174.0
GSDYVNANYIDGYRKQNAYIATQGSLPetfgdFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSrgtethglvqvtlldtvelatycvrtfalykNGSS
|||| ||...|...  . .||.|| |.     ||.|..|... ||||.....|. ..|| .|||.                               . ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKREVRQFQFTAWPDHGVPEHPTpFLAFLRRVKTCNPP-DAGPMVVHCSAGVGRTGCFIVIDAMLERIKhEKTVDIYGHVTLMRAQRNYMVQTEDQYIFI
..|.. |.... |||||||. .. .| |...|...    . ||..|||||||||||...... || ... |..||.. .|  .| || .||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy
0049772 (Phosphotyrosine protein) phosphatases II 1654-1924 3.7e-48 160.2 In-house 11-280 (314) alignment 
Range on Protein: 1654-1924
Range on HMM: 11-280/314.0
QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYEsTRVCLqPIRGVEGSDYINASFIDGYrqqKAYIATQGPLAETTEDF-----
.. . .......|...|.  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .| .||     
ellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepv

-----WRML--WEHNSTIVVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTV
     |||   ...|. ..||                     |..| . |      ...|.. . ..                    .... ..  .|..
lyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlg

RQFQFTDWPEQGVPkSGEGFIDFIGQVHKTkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERMryeGVvDIFQTVKMLRTQRP-----AMVQTEDQYQF
 ..  ...|  ..| . | | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. ......| .||      .... .||.|
ikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyef

SYRAALEYL
 ..| ||||
ilealleyl
0043147 (Phosphotyrosine protein) phosphatases II 1426-1626 3.8e-47 155.5 In-house 3-154 (172) alignment 
Range on Protein: 1426-1626
Range on HMM: 3-154/172.0
PGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLeersrvkcdqywpsrgtethglvqvtlldtvelatycvrtfalYKNGS
.||||.||.|.|.|.. . .||||| |..|. |||||..|.   ..|..|.|                                           .....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SEKREVRQFQFTAWPDHGVPeHPTPFLAFLRRVKT-CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLerikheKTVDIYGHVTLMRAQRNYMVQTEDQYIF
 ..|.. |.... ||||||| ..  .| ||. ... ..  . ||..|||||||||||...... ||      . ....  | |.|..|...||...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IH
..
ly
0043147 (Phosphotyrosine protein) phosphatases II 1715-1917 1.1e-46 154.0 In-house 3-154 (172) alignment 
Range on Protein: 1715-1917
Range on HMM: 3-154/172.0
EGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||..|.|.  . .||||||| .|..||||||.|.. |..|.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTVRQFQFTDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQDGPISVHCSAGVGRTGVFITLSIVLERMryegvvDIFQTVKMLRTQRPAMVQTEDQYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FSY
| |
fly
0046846 (Phosphotyrosine protein) phosphatases II 1708-1925 2.5e-46 152.9 In-house 3-174 (176) alignment 
Range on Protein: 1708-1925
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFIDGYRqqkaYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||..|.|.|    .||||||| .|..||..||.|.. |.||.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtvrQFQFTDWPEQGVPKSgEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFITLSivleRMRYEGVVDIFQTVKMLRTQRP-AM
              |.....||. ||| . | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDQYQFSYRAALEYLG
|||..||.| |...|..|.
vqtpeQyrflyefellllk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1675-1922 3.9e-46 152.3 In-house 19-293 (297) alignment 
Range on Protein: 1675-1922
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE
.|..  | ||. .    |||  .|. ...||| |.  |.. ..||||| ..      ..  || .|||| .| .|||....|..  ..||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| ||  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   ...|| ||. .||| .|... | |.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_ptpA1_pd Subfamily ptpA1 1376-1595 7e-46 151.8 In-house 26-258 (418) alignment 
Range on Protein: 1376-1595
Range on HMM: 26-258/418.0
KFSQEYESIDPGQqfTWEhSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGY-RKQnaYIATQGSLPETFGDFWRMIWEQRSATVVMM
.|    ||. | .  | |  . . |  ||||.|..  .|.|| |  |.   ||||.|||||||   ||  .|.||| ||.|  |||||.||.|   .||.
efrlleesvgpse..tse.gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivml

TKLEERSRVKCDQYWPS-----------RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--
..  |  |.|||.|||             | |  |   | |.. ..     . |  .      | |.. |.|.  |||| .|.|  ||  .|. .     
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

--NPP--DAGPMVVHCSAGVGRTGCFIVIDAMLERIKH
   |      |..||||||||||| |     |.... |
qiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
0046846 (Phosphotyrosine protein) phosphatases II 1426-1630 8.6e-46 151.2 In-house 10-170 (176) alignment 
Range on Protein: 1426-1630
Range on HMM: 10-170/176.0
PGSDYVNANYIDGYRkqnaYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSrgTETHGLvqvtlldtvelatycvrtfalykngs
...||.|||.|.|.|    .|||||.||.|. ||..|..|..  .||..|.. | .|.||..|||    |..|.                          
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

sekrevrQFQFTAWPDHGVPEHpTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDamleRIKHEKTVDIYGHVTLMRAQRN-YMVQTEDQYIF
       |.... |||||||.. . .| .|. ....   . || .||||||.||||......     ...|| ....  . |.|.||  ..|||..|| |
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

IHDALL
.....|
lyefel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1386-1631 3.6e-45 148.8 In-house 42-281 (290) alignment 
Range on Protein: 1386-1631
Range on HMM: 42-281/290.0
PGQQFtwEHSNLEVNK--PKNRYANVIAYDHSRVLLSaiEGIPGsDYVNANYIDGYRkqNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV
|.|..  | . .. |    |||| .|.  | .||.|.  .| .| ||| |||..| .    .| |||.| .|  |.|||. ... |..||. .| |  . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPSRGTETHGLVQVTLLDTV---ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCnppdAGPMVVHCSAGVGRT
||.||.| .  |.  . ..|.| .    . |    .|... .  |  .  .. ..  .|||. |.     .|  || ...     .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
| |. |.. |. . . | .|. . |  .|  |   || . ||. . ..||.
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1377-1631 1e-44 147.6 In-house 8-257 (267) alignment 
Range on Protein: 1377-1631
Range on HMM: 8-257/267.0
FSQEYESIDPGQQFTW--EHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
. .|.| |.   . .     |  | |. .||. ... ||..|| |.  |     .|.|| |..||...||.|.||..|  | .||. .| .|. ...|..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKLEERsrvKCDQYWPSRGTETHGLVQVTLLDTVE--LATYCVRTFAL-YKNGSSekREVRQFQFTAWPdhgVPEHPTPFLAFLRRVKTCNPPD--AGPM
||  .    .  ..|| .  ...   ..|.  ..|     | . |. | .|| |.  ..|  . .  |    .     |.|  |  . . |  .    |.
tkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa..hnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPl

VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
||.||.||||.| |.|||..|||.|.| ..||.  .  .| ||  .|.| ..||.||. | |
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0049260 (Phosphotyrosine protein) phosphatases II 1435-1627 2.4e-44 146.0 In-house 1-144 (152) alignment 
Range on Protein: 1435-1627
Range on HMM: 1-144/152.0
YIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWpsrgtethglvqvtlldtvelatycvrtfalykngssekrevrQF
.||||......||||| .|.|. |||||..|.   |.||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLerikheKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
... |||||||...  .| .|. .. ..  . || .|||||||||||...... ||      . |...  | |.|..|...|....|..|...
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 1390-1635 1.5e-43 145.1 In-house 36-282 (314) alignment 
Range on Protein: 1390-1635
Range on HMM: 36-282/314.0
FTWEHSNLEVNKPKNRYANVIAYDhSRVLLsAIEGIPGSDYVNANYIDGYrkqNAYIATQGSLPETFGDF----------WRMI--WEQRSATVVM----
.|.  ..|..|. |||| ... .| .|| |   ... |||| ||.|.||.   ...||||| |..|. ||          |||.  ..... ..||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTKLEERSrvkcDQYWPSRGTETHglvqvtlldtvelatycvrtfA-------LykngsseKREVRQFQFTAWPDHGVPeHPT
                  ..| ..     .......  . .                             .       .|.. ..  . .||...|  . 
vladelsrLdaAlgKtpllildgng....neptaadlellk.....................eelydpelf.......erlgikylripvpDgsap.lle

PFLAFLRRVKTCnpPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHeKTVDIYGHVTLMRAqRN---YMVQTEDQYIFIHDALLEAVTC
 |..||. ....  .. || .|||.||.||||.|.|.. .. . .     ... .| |.|   |    .... .||.||..||||..  
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1396-1631 2.4e-43 143.3 In-house 37-275 (307) alignment 
Range on Protein: 1396-1631
Range on HMM: 37-275/307.0
NLEVNKPKNRYANVIAYDHSRVLLSaIEGIpGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTE
 .. |  |||| .| . |..|...  ..|.  |||. |||.    | . .|..|| | .|  .|| |. ...  .|.|. |. | ...||.||||    .
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

THGL------VQVTLLDTVELA--TYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVID
.         . |. | . .||    ..   .|  . ... | ....|.. |||.|||.     . .|  |.     |  |.||||||||||.|  . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivais

AMLER-IKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
 . .. |. .   |.   |  .|.||.| .||| ||...|  |||
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0049260 (Phosphotyrosine protein) phosphatases II 1724-1917 4.6e-43 141.8 In-house 1-143 (152) alignment 
Range on Protein: 1724-1917
Range on HMM: 1-143/152.0
FIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtvrQF
|||||......||||||. .|..||||||.|.. |..||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQDGPISVHCSAGVGRTGVFITLSIVLermryeGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY
... ||  |||.. . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|...|..|| .|....|..| |
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1667-1923 4.8e-43 142.1 In-house 11-258 (267) alignment 
Range on Protein: 1667-1923
Range on HMM: 11-258/267.0
E---FKRLASSKAHTSRFISANlpcNKFKNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
|    |.... ..  | .|. .   |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  |  ||. .. ... ...|.|
efelikkisdtsstisqsiaek...nqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYI--LREFKVtdaRDGQSRTVRQFQFTDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqDGP
||    . .. ...|| .  .. .|| ..|.   | .  .|     |.|.   ..  .. |  . .  |  .   |    .  ..| . | . . | . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrP

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
. |.||.||||.| |...   |||.. |||.|||. .. .| ||...|.| ..| . ..   ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1661-1924 2.8e-42 139.8 In-house 15-277 (307) alignment 
Range on Protein: 1661-1924
Range on HMM: 15-277/307.0
VTGMELEFKRLASSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVeGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
|. .  ||. ||  . ..       . .|  |||  ..   . .|. .. . |.  |||| | ..    . | .|..|||| .|  .|| |  ...   |
vqalvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktke
.|| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..|||....|...||..|||.   . |...  |.    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

qfGQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  ..  |. |||||||||.|  ...|.| ..| . .   |. . |. ||.||.  .||| || . .|  |||.
..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0051082 (Phosphotyrosine protein) phosphatases II 1716-1920 7.5e-40 131.3 In-house 2-149 (151) alignment 
Range on Protein: 1716-1920
Range on HMM: 2-149/151.0
GSDYINASFIDGYrqqkaYIATQGPlaetTEDFWRMLWEHNSTIVVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . .|.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryegvVDIFQTVKMLRTQRPAMVQTEDQYQF
  ..|......|||..|.| | . ...|. .. .      ..||. ||||||.||||... | ..|..      |.........| .|| .||...|..|
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

SYRAA
 ..| 
qlfal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1380-1631 9.2e-40 131.1 In-house 35-287 (305) alignment 
Range on Protein: 1380-1631
Range on HMM: 35-287/305.0
EYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipGSDYVNANYIDGY-RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
 |   |  |.        .... ||||..| . |.| |.|.       |||. |||.      .. .|..|| | .|  .|| |. ...   .||. |  
kytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktv

ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVR-------TFALYKnGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVV
|  ..|| ||||    | . |    ... |  .    |       .. |     ..|  ||..|.| ||| |||      | .|  ..  .     |.||
elgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivv

HCSAGVGRTGCFIVIDAMLERIKHEKTVD-IYGHVTLMRAQRNYMVQTEDQYIFIHDALLE
|||||.||||  . |. .||.|  .| .  .   |  .| || . .|.. ||.|||  .|.
hcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1379-1643 1.7e-39 130.2 In-house 31-299 (310) alignment 
Range on Protein: 1379-1643
Range on HMM: 31-299/310.0
QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSaIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE
..|  .|  |. .  .   . .  ||||..|.  | ||| |  |.     ||. |||.     ....| .|| |  |  ||||||...|. ..... |  
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvg

ERSRVKCDQYWPSRG-TETHGLVQVTLLD----TVELATYCVrTFA----LYKNGSS--EKREVRQFQFTAWPDHGVPEHPTPFLAflRRVKTCNppDAG
|  | ||  |||| | |||.| ..|| |       |.   .| ||        .  .  ..  |   ..  ||| |||.     .   .|. .      |
eegrpkcvgywpslgvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqv..rhg

PMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLeAVTCGNTEVPAR
| |||||||..|... . ..  ...... . ||.   .| .. .|   .||| ||..|.   . . . |.|||  .
pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaek
subfamily_ptpA1_pd Subfamily ptpA1 1682-1884 8.7e-39 128.4 In-house 40-256 (418) alignment 
Range on Protein: 1682-1884
Range on HMM: 40-256/418.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRqQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAE
   .   |  |||  ||.| . ||| |. |.  |||||||| .|||    | .|.||||| .|  |||||.||    |.|||..  |  | || .||| .
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

RSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF----GQDGPISVHCS
     |. .       .  |     .. |   ||        . .|..| . |.|.  ||.. .|   . | ...  . . ..|      .. || ||||
igg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRTGVFITLSIVLERM
||||||| | |  |.....
agvgrtgtfctavimmkkl
0044763 (Phosphotyrosine protein) phosphatases II 1700-1917 1.4e-38 127.7 In-house 1-164 (178) alignment 
Range on Protein: 1700-1917
Range on HMM: 1-164/178.0
PYESTRVCLQPIRGVEGSDYINASFIDGYrqqkAYIATQGPlaettEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||.|...     |.....|     .|....|.|.. | .|.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtvRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryeGVvDIFQTVKML
                      |.... .|  ||| . | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... ....
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDQYQFSY
| .|| .|....|... |
rerRp.ivpnpgqlrqLy
0044763 (Phosphotyrosine protein) phosphatases II 1412-1630 2.3e-38 127.0 In-house 2-168 (178) alignment 
Range on Protein: 1412-1630
Range on HMM: 2-168/178.0
YDHSRVLLSAIEGIPGSDYVNANYIDGYrkqnAYIATQGSlpetfGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTethglvqvtlldtvela
.|..||||| .||...||| ||..|...     |......      |......|.   ..|..|.  |. ..|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tycvrtfalykngssekrevRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERikhekTVDIYGHVTLMRAQ
                     |.... .||||||. .  ||.|.. .... ... || .|||||||||.|...... |...      ....  . |.|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYIFIHDALL
|. .|....|. ....  |
Rp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1682-1923 6.5e-38 125.0 In-house 30-268 (281) alignment 
Range on Protein: 1682-1923
Range on HMM: 30-268/281.0
ISANLPCNKFKNRLVNIMPYESTRVCLQP-IRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA
   | | |. ||| .||   . .|| |.  .   . .||| | .|     .. || ||||  ||  |||||.|. |.| .||| .. |  |||| .|.| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSIV
.  .  |.  .    |    .  |   ..  . .|..| . .. . .||.  ||.| | ..  . ...       .  |  .||||||||.| .... | 
nahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveia

LERMRY-EGVVDIFQTVKMLR-TQRPAMVQTEDQYQFSYRAALEY
|. ..    . || | |  || | | | ||| .|| . ..  |..
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1394-1631 7e-38 124.9 In-house 31-267 (281) alignment 
Range on Protein: 1394-1631
Range on HMM: 31-267/281.0
HSNLEVNKPKNRYANVIAYDHSRVLLSA-IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR
  |  ||. ||||.|. . | ||| |   .     .||. ||||     .  || |||   ||  |||||||.. ....||. .. |  | || .|.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

GtetHGLVQVTLLDT-VEL--ATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCnppdAGPMVVHCSAGVGRTGCFIVIDAM
    |  .|.  |    |       . |  |      | | . .. .  |||  |||    .|  ||....     . | |.||||||||.| .. ..  
a...hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveia

LERIKHEKT-VDIYGHVTLMRA-QRNYMVQTEDQYIFIHDALLE
|. |.   |  ||   |. .|   |   ||| .||..|   ||.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0051082 (Phosphotyrosine protein) phosphatases II 1427-1630 1e-37 124.4 In-house 2-150 (151) alignment 
Range on Protein: 1427-1630
Range on HMM: 2-150/151.0
GSDYVNANYIDGYrkqnaYIATQGSLPetfgDFWRMIWEQRSATVVMMTKLEERSrvKCDQYWPSRGtethglvqvtlldtvelatycvrtfalykngss
 ||| |..|..|.     .....| |.    ||.....|.   |.|.....|||   .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnpPDAGPMVVHCSAGVGRTGCFIVIDAMLERikhektVDIYGHVTLMRAQRNYMVQTEDQYIFIH
  .||...... |||.|.|...  .|.||. .     .. ||..||||||.||||...... ||..      |...  .  .|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DALL
 |||
fall
PTPc_DSPc_SM00012 1819-1922 1.2e-37 123.7 In-house 1-105 (105) alignment 
Range on Protein: 1819-1922
Range on HMM: 1-105/105.0
TVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSY
||.....|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . |||||.||.||.||| |||||.||.| |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAALE
|| ||
ralle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1396-1633 1.4e-37 124.2 In-house 31-270 (285) alignment 
Range on Protein: 1396-1633
Range on HMM: 31-270/285.0
NLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGY-RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT
  | |   ||||.| . . .||.|   .     ||. |...    . |..||.||| ||||. |||.||.... | |.|.  | |    ||  |.| .  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

ET--HGLVQVTLLDTVELATYC----VRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDA
|    |  ..|| .  | |         |    .. |||   . . |   |||.  ||   |.. . . ||  || .  |..||||||||||  |. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidy

MLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
   ||  .  ...   |  ||| |   ||.  |..|..  |.| .
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf
PTPc_DSPc_SM00012 1531-1631 2.9e-36 119.2 In-house 2-105 (105) alignment 
Range on Protein: 1531-1631
Range on HMM: 2-105/105.0
VRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDA--GPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHD
|.....|.||||||||.....| .|| ||...   .  .|.||||||||||||.|...| .|.....| |.|||.  |  .| ||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1691-1924 3.7e-36 119.3 In-house 58-283 (290) alignment 
Range on Protein: 1691-1924
Range on HMM: 58-283/290.0
FKNRLVNIMPYESTRVCLQpiRGVEGsDYINASFIDGYRqqKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|..|. |.|||. ... . .||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |..|   ..  .  . |.       ||. ||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .|. ..|. ||  | . || . ||    .. |.. 
keldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1401-1631 2.6e-35 116.6 In-house 49-285 (305) alignment 
Range on Protein: 1401-1631
Range on HMM: 49-285/305.0
KPKNRYANVIAYDHSRVLLsaiEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH---
. |||| .|   |. || |   ||    .|. |||.    . . .| ||  | .|  ||| | ....  .. |. .| |.   || .|..|.  ..    
agknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---GLVQVTLLDTVEL-----ATYCVRTFALYKNGS-SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKtcnpPDAGPMVVHCSAGVGRTGCFIVIDA
     ..| .  .|.|     |   |.   |  .|. ...| | .. .  ||| |||   .  | .| . .    |  ||.|||||||.||||  .... 
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmley

MLERIKHEKTVDIYGHV-TLMRAQRNYMVQTEDQYIFIHDALLE
.|...   . ..   ..   .| |||  .||..||.|.|. .|.
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1689-1924 6.2e-34 112.0 In-house 55-289 (305) alignment 
Range on Protein: 1689-1924
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGY-RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   . . | |.       |||| | ..      .| .|..|||| .| ..|| |. ...   .||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqfGQDGPISVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. .||..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||..  .  .  . . || || ||   .|.. || | .|  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1720-1913 1.9e-33 110.5 In-house 78-270 (301) alignment 
Range on Protein: 1720-1913
Range on HMM: 78-270/301.0
INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | .|.   . . .||||||| .|.|||| ||  ..   .|||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY
 ..|||  .|...|...|||||     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||. | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1400-1554 2e-33 110.5 In-house 33-189 (297) alignment 
Range on Protein: 1400-1554
Range on HMM: 33-189/297.0
NKPKNRYANVIAYDHSRVLLSaiEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT--E
   |||| ...|.| .|| |    .|...||.||.|.      ..  || .|| | .|  |||....||   ..||..||.|  | ||  ||||      
slrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

THGLVQVTLLDT--VELATYCVRTFALYKNgsSEKREVRQFQFTAWPDHGVPEHPTPFLAF
. | | |  | .   |  .  .  . |.    ||.| ||  || .|||||||        |
kagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_CG42327_pd Subfamily CG42327 1400-1560 1.2e-32 107.9 In-house 28-192 (319) alignment 
Range on Protein: 1400-1560
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRK-QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR----GT
 |.|.|..||.   ..|| |  |   . . |..|.|. ||.. .| |||.| || ..  ||||..|||.| ..| .|.| |    .| .|.|..    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFtAWPDHGVPEHPTPFLAFLRRVKT
...| ..||| .      | . |. | .   .| ||.  . .  |.. .|| ......| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1673-1924 1e-31 105.1 In-house 27-271 (288) alignment 
Range on Protein: 1673-1924
Range on HMM: 27-271/288.0
SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE
 |  ..|  |  .   |  ..|  |.   . ||| |.     .   ||.|  .   . ..  | .| ||  | | .|.|| | .   .|||..| | |.|
dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCHQYWPAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVG
|  .|.| .   .||.. .  .   ...  . ...   .   . |. .  |..  . .|...|||..   .. ..  .         . || ||.|||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvG

RTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
||| .|   |.|| .| .  . | . .. || .|   .||| || . .|  ||.|
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1400-1635 3.7e-31 103.2 In-house 43-273 (288) alignment 
Range on Protein: 1400-1635
Range on HMM: 43-273/288.0
NKPKNRYANVIAYDHSRVLLSaiegIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGL
|  ..|| |.   | .|| ||         |..|| .   . ..  | .|  |  | . .|.|. |.    .||...| |. . | ..|.||.  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

V---QVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVVHCSAGVGRTGCFIVIDAMLERIKHE
    .|.  . ...    . .    ..   ||  |..  .  |.|.||||   ..| .| ..|...     |.|||.|||||||| .|.|  .|| .. .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrld

KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTC
  . |   .. .|..|   .||| ||...|  .|| .  
dflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1689-1924 4.3e-31 102.9 In-house 35-270 (285) alignment 
Range on Protein: 1689-1924
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYESTRVCLQPirgvEGSDYINASFID-GYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| ||  |||.|... . . |.||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  |.  .  ..... |. .|. |   ||.  |. | |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1689-1924 3.4e-30 99.8 In-house 48-287 (305) alignment 
Range on Protein: 1689-1924
Range on HMM: 48-287/305.0
NKFKNRLVNIMPYESTRVCLQPirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQY
.. |||  ..   .  || |..       .|| | ..    . | .| || || .|  ||| | ....   . || .| | | .||..|....     ..
eagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

F------VVDPMAEYNMP------QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFIT
       .|   .  ..         . .   | .   ...| | .. . |||..||| .    .... .   .|      ||| ||||||.||||  . 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvm

LSIVLERMRYEGVVD-IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
|  .|...    ...   . .. .| ||   .||..|| | ..  |.|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_CG42327_pd Subfamily CG42327 1687-1851 1.3e-28 94.6 In-house 26-194 (319) alignment 
Range on Protein: 1687-1851
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK-AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| ... ||||..|| .| ..| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFtDWPEQGVPKSGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .|| . . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
0048076 (Phosphotyrosine protein) phosphatases II 1503-1630 1.4e-28 94.8 In-house 18-140 (145) alignment 
Range on Protein: 1503-1630
Range on HMM: 18-140/145.0
TLLDTVELATYCVRT-FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDAMLErikheKTVDI
| ||  .|. . ..| . |  . . ..|.. |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.     . |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

YGHVTLMRAQRNYMVQTEDQYIFIHDALL
.  . |.|.|| ..|....|..|.....|
eealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1396-1624 6.4e-28 92.4 In-house 46-272 (301) alignment 
Range on Protein: 1396-1624
Range on HMM: 46-272/301.0
NLEVNKPKNRYANVIAYDHSRV-LLSAIEGIPgsdyVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT
.  ..| |.|| .|    .. | ...  . .|    . ||.|.   . . .||||| |..|  ||| |.      ..||...  |.   ||..| |.. .
yaylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

ETHGL--VQVTLLDTVELAT--YCVRTFALYK-NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNppdaGPMVVHCSAGVGRTGCFIVIDAM
|.  .   .... ..  .       ||. .    |  . | |  .|.. |.|.|||.  .    ..  ||  .     |.|||||||.||. .||  . .
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteyl

LERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIF
  ... ..|...   .  .| .|   |||. |  .
areveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1520-1655 2.4e-27 90.3 In-house 81-216 (440) alignment 
Range on Protein: 1520-1655
Range on HMM: 81-216/440.0
LYKNGsSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN-PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT
 | ||  | | ..|... .|||.|||.   | | ... |. ..     ||..||||||.||||  |..|..|   |.   .||.  .  || .|  ||||
sying.iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

EDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQI
 .|| |.|.|.||.. ||.| .   ..   ....   
peqyafvheavlegllcgdtliledditerveqiqwp
0048179 (Phosphotyrosine protein) phosphatases II 1513-1627 2.6e-27 90.7 In-house 31-139 (144) alignment 
Range on Protein: 1513-1627
Range on HMM: 31-139/144.0
YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDaGPMVVHCSAGVGRTGCFIVIDAMLerikHEKtVDIYGHVTLMRAQR
..| ...      ...||. |.... |||||||.... .|.||. .... ... ||..|||||||||||...... |.    ... ....  . |.|..|
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

NYMVQTEDQYIFIHD
 ..|....|..|...
pgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1729-1918 4.1e-27 89.6 In-house 2-198 (199) alignment 
Range on Protein: 1729-1918
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQ
. |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.| |.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1730-1918 5.3e-27 89.3 In-house 2-197 (198) alignment 
Range on Protein: 1730-1918
Range on HMM: 2-197/198.0
QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQF
 |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.| |.
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1401-1634 9.1e-27 88.6 In-house 44-277 (312) alignment 
Range on Protein: 1401-1634
Range on HMM: 44-277/312.0
KPKNRYANVIAYDHSRVLLSAIEGIpgsdYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR----GTET
|  ||| |.  .|  |  |.  | .    |. ||..    | . ...||| | .|   ||..     |....... . | .  || .|          | 
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

HGlVQVTLLDTVELATY-----CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVIDAMLE
|  |       .|.          | . .  . . ..  . ..|...|||||.|.     | .|  ||     |  |.. |||||||||| ...|..|. 
hr.vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmia

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
 ..| .  ..     |.| .|   |..  ||..   ..|| . 
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_egg_pd Subfamily egg 1391-1630 3e-26 86.8 In-house 31-267 (307) alignment 
Range on Protein: 1391-1630
Range on HMM: 31-267/307.0
TWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrVKCDQYWP
. ...  . |. | |   |   | ||| |   .|    |.. ||...|    | .| .|  | .|  |||||.....   .||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

SRGTETH----GLVQVTLLDTVELATYCVRTFALYKNG-SSEKREVRQFQftaWPDHGVPEHPTPFlAFLRRVKTCnppdAGPMVVHCSAGVGRTGCFIV
   ...     | .... |.  . |    |   |   |   |.| .  .|   .  . . .  .|.   ||...      . |.||..  || ...... 
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvyspl.rvlrklrnl....skpvvvqdilGvskaatlva

IDAMLER-IKHEK-TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
|.  |   ..       .   | ..| .|.. |..  .|.|..  .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1688-1920 8.9e-26 85.2 In-house 51-286 (310) alignment 
Range on Protein: 1688-1920
Range on HMM: 51-286/310.0
CNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARY
 .  |||  ...  ...|| |. |      ||| | ..     ....| .||||  |  |||||...  .  ...| |  | || ||  |||.   .  |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

QYFVVDPMAEYNMpQYILREFKVTDA-----RDGQS-----RTVRQFQFTDWPEQGVPKSGegfIDFIGQVHKTkeQfGQDGPISVHCSAGVGRTGVFIT
    |  ..|    .. . .. ||        | |        |   .. .||..|||         . |   .  |  . ||  ||||||..|..| ..
gcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvva

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
| . .....    ||. . .  |. .|   .||| || .  |  
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_egg_pd Subfamily egg 1661-1921 3.6e-25 83.3 In-house 13-267 (307) alignment 
Range on Protein: 1661-1921
Range on HMM: 13-267/307.0
VTGMELEFKRLASSKAHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIV
| ..|  .. |  |  . |   .|.   |. | |   .   .|.|| |.  ||    |.| |  ..|      .| .| || .| .|||||... .   .
vqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtvRQFQFTDWPEQGVPKSGEGFIDFigQVHKTKEQFG
||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .|.. .  .  .| .   .  
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnls

QdgPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL
.  |. |..  || ........ | |  .    .    . ..|..|| .|.  |..  .| | ||  |
k..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048076 (Phosphotyrosine protein) phosphatases II 1803-1923 1.3e-24 82.0 In-house 36-142 (145) alignment 
Range on Protein: 1803-1923
Range on HMM: 36-142/145.0
IlrefkvTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQ
.      |. ... .|.. |.....||  ||| . | ...|. ....  ..   .||. |||||||||||...    ..  |...| |.........|.|
l......tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsq

RPAMVQTEDQYQFSYRAALEY
|| .|....|..| |.. ||.
rpgavpnpgqlrflyefelel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1692-1930 1.2e-23 78.3 In-house 46-282 (312) alignment 
Range on Protein: 1692-1930
Range on HMM: 46-282/312.0
KNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| .|.  ||..     || ...|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| | .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHY
.|.    .. ..  .|| .|   |..  || .. |. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1691-1780 1.5e-23 78.1 In-house 49-152 (350) alignment 
Range on Protein: 1691-1780
Range on HMM: 49-152/350.0
FKNRLVNIMPYESTRVCLQ----P----IRGVEGSDYINASFIDGY----RQQKA--YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ
 ||| .||.||| .|| |.    .       ....|||||...       ...    |||||.|| .| .||.... . . .....||.. |...|||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPA
||. 
YWqe
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1569-1636 2e-23 76.5 In-house 1-68 (69) alignment 
Range on Protein: 1569-1636
Range on HMM: 1-68/69.0
MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG
||||||.| |||| || |   . ||| || |||.  |  ||  |  ||  | .|||||||| ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1816-1925 5.2e-23 76.1 In-house 87-195 (440) alignment 
Range on Protein: 1816-1925
Range on HMM: 87-195/440.0
QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|||  .. .| .|| |||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

SYRAALEYLG
 . | || | 
vheavlegll
0048179 (Phosphotyrosine protein) phosphatases II 1805-1915 1.8e-22 75.0 In-house 48-136 (144) alignment 
Range on Protein: 1805-1915
Range on HMM: 48-136/144.0
RefkvtdardgqsrtVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEGvVDIFQTVKMLRTQRP
               . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||||.....     .|...| ..........|..||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQTEDQYQF
 .|....|..|
gavpnpgqlrf
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1570-1636 2.6e-22 73.0 In-house 1-67 (69) alignment 
Range on Protein: 1570-1636
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCG
|||||.| |||| || |   . ||| || |||.  |  ||  |  ||  |..|.|||||| ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1402-1497 3.1e-22 73.8 In-house 49-158 (350) alignment 
Range on Protein: 1402-1497
Range on HMM: 49-158/350.0
PKNRYANVIAYDHSRVLLS-------AI-EGIPGSDYVNANYIDGY---RKQN---AYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQ
 |||| |.. |.|||| |        |.   . ..||.||||.       ..|    |||||. ||.|. ||...| .     ....|.. |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSRGTETH
||.  . . .
YWqegsyddi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1442-1631 6.6e-22 72.8 In-house 34-219 (255) alignment 
Range on Protein: 1442-1631
Range on HMM: 34-219/255.0
QNAYIAtqgslpeTFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQFTAW
.| |.        |   |...|  ... .|||.. ..| ...||..|.|    |   | .|..  |   |   .||  .  . .   . ..|. .... |
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW

PDHGVPEHPTPFLAFLRRVKtcnppDAGPMVVHCSAGVGRTGCFIVIDA----MLERIKHEKTVDIY--GHVTLMRAQRNYMVQTEDQYIFIHDALLE
...  || .   |  |. |.     |. ..|||||.|.||.  |....     |.  ..  .||..     .. .| .|.  ..|  |  |    .|.
ieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1441-1626 1.5e-21 71.5 In-house 3-197 (199) alignment 
Range on Protein: 1441-1626
Range on HMM: 3-197/199.0
KQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQF
 |  ||||| .| ||. |||.|.||  |  .||.   .    .    |||.   ||  .| . ||    .  . |.. .. | .| ..    ||. ..||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPEHPtPFLAF---LRRV-KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIH
|.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1442-1626 2.1e-21 71.0 In-house 3-196 (198) alignment 
Range on Protein: 1442-1626
Range on HMM: 3-196/198.0
QNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSS--EKREVRQFQFT
|  ||||| .| ||. |||.|.||  |  .||.   .    .    |||.   ||  .| . ||    .  . |.. .. | .| ..    ||. ..|||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPEHPtPFLAF---LRRV-KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIH
.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
fn3 Fibronectin type III domain 922-1006 1.5e-19 63.1 Pfam-A 3-85 (85) alignment 
Range on Protein: 922-1006
Range on HMM: 3-85/85.0
PQNLHSEGTTSTSVQLSWQPPVlaERNGIITKYTLLYRDINIPLlPMEQLIVPADT-TMTLTGLKPDTTYDVKVRAHTSKGPGPYS
|.||. ...||||..|||.||   ...| ||.|.. ||. . .  .  .  ||..| ..|||||||.|.| ..|.|.. .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1661-1923 1.8e-19 64.3 In-house 25-284 (302) alignment 
Range on Protein: 1661-1923
Range on HMM: 25-284/302.0
VTGMELEFKRLASSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETT---EDFWRMLWEHNS
 . .. |||.... |... .        |  ||.  ..  ..|..| |.     |  .|.||| ..    ..  | .| |  ...   |.|||| .... 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

TIVVMLTKLREMGReKCHQYWP--AERSARYQYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKE
. ||.| .  |. .   ....|  ..    |. . |     |.   .    .. .    .| | .|      .| |... ||..    |  . .|   ..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fak

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
.   | .. .    |.|| |.|.|| ...|..  .  . | ..|| .|.|||..|.. .|| . |.|.| |
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1454-1625 2.7e-19 63.7 In-house 102-280 (302) alignment 
Range on Protein: 1454-1625
Range on HMM: 102-280/302.0
ETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVT--LLDT-VELATYC-VRTFALY-------KNGSSEKREVRQFQFTAWPDH
.|   .| .| . . | || .... |    || .|.  .  ..  . . |   ..   .|. .   ..| ||       |  .  |. |  ..|.|||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPEHPTPFLAFLRrvkTCNPPDAgPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFI
| |... . |  |.    |.      ..||||||||||| .. |   ..  ...|. |.   |. .|. |   ||.|.| |..
Gapkeaytaldilk...fcesykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
fn3 Fibronectin type III domain 612-699 4.2e-19 61.6 Pfam-A 2-85 (85) alignment 
Range on Protein: 612-699
Range on HMM: 2-85/85.0
PPQDISCTSPSSTSILVSWQPPPveKQNGIITEYSIKYTAVDGEDDKPHEIlgIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES
.|...|... .|||. .||.||.  ...| || |...|  ..|.... .    .|..|| . |..|.  |||...|.|....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeft..vprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1399-1633 1.7e-18 61.3 In-house 46-279 (303) alignment 
Range on Protein: 1399-1633
Range on HMM: 46-279/303.0
VNKPKNRYANVIAYDHSRVLLSAiegipgSDYVNANYIDGYRKQNAyIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT---E
 |  |||...||  |||.| ||       | |. |.|..   ...| | ||  |. |  |||.|| ||.   |...    |  ..  |  .|        
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

THGLVQVTLLDTVELATYCVRTFALYKNGSsEKREVRQFQFTAWPDHGVPEHPTP-FLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAM-LE
 .  ..|  .  |||.   |       ||.  |  .   .. |||   .| . .| |.  . ....   .  |. | |    .|.||.| | ....  | 
eersirvgefkrvelgdgwvlkvlsvsngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
  . . ..|.   .  .|  | . ||   |. ...  | | |
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1744-1924 4.3e-18 60.3 In-house 40-221 (255) alignment 
Range on Protein: 1744-1924
Range on HMM: 40-221/255.0
TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFI
| . |....   ... ||||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .||. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
  .  |...|       .. ||||.|.||.  |.   .|  .|    .    . .|  . .. || .|.. ..|  |  ||    |...
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
fn3 Fibronectin type III domain 518-595 6.4e-18 57.9 Pfam-A 2-83 (85) alignment 
Range on Protein: 518-595
Range on HMM: 2-83/85.0
QPLNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEHGE-EQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQGLGA
.| |..... ..||. |||.||.  ...| .||. |.. ..|| ....|... | |. |.||||.. | ||..|.. .| | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1726-1913 6.8e-18 59.1 In-house 84-277 (302) alignment 
Range on Protein: 1726-1913
Range on HMM: 84-277/302.0
DGYRQQKAYI-ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  .|.| .| .. ..| .||| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIgqvhKTKEQFGQDgpISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY
. . .||  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|.| 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
fn3 Fibronectin type III domain 325-405 7.2e-18 57.7 Pfam-A 2-85 (85) alignment 
Range on Protein: 325-405
Range on HMM: 2-85/85.0
PPGTPVVTESTATSITLTWDSG--NPEPVSYYIIQHKPKNSEE--LYKEIDGVATtRYSVAGLSPYSDYEFRVVAVNNIGRGPPS
.|. . |.| |.||.||.|.    . .|...| .. ..|...|    . ... .| .. . || |...||||| |||. | ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 714-812 9.5e-18 57.3 Pfam-A 2-85 (85) alignment 
Range on Protein: 714-812
Range on HMM: 2-85/85.0
PPRKVEVEAVNSTSVKVSWRSPVpnKQHGQIRGYQVHYVRMENGEpkgqpmlkdvmlaDAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS
.|. . |..|.|||. .||  |   ...|.| ||.|.|  ...||             . ..   . |.. ....||.| |.|...|.|....| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_hpo-7_pd Subfamily hpo-7 1442-1634 1.7e-17 58.2 In-house 37-228 (263) alignment 
Range on Protein: 1442-1634
Range on HMM: 37-228/263.0
QNAYIAtqgsLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGS--SEKREVRQFQFTAW
.| |.     | .|   |...|  ... .|||..  .| ...||..|.|    |   | .|..  |       ..|  | .. .   . ..|...... |
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgW

PDHGVPEHPTPFLAFLRRVKtcnppDAGPMVVHCSAGVGRTGCFIVIDA----MLERIKHEKTVDIY--GHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
...  || .   |  |. ..     .  ..|||||.|.||.  | |..     |.  ..  .||..     .. .| .|.  ..|  |  |    .|. |
iekndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

T
 
l
fn3 Fibronectin type III domain 419-504 7.3e-17 54.5 Pfam-A 1-85 (85) alignment 
Range on Protein: 419-504
Range on HMM: 1-85/85.0
SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHvnNWMKHNVADSQ-ITTIGNLVPQKTYSVKVLAFTSIGDGPLS
|||......  .||.. ..|..|....|.|.||.| | .. ...   |   .|  ..   |. .| | ..|...| | .  | || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
I-set Immunoglobulin I-set domain 24-115 8.9e-17 52.7 Pfam-A 1-90 (90) alignment 
Range on Protein: 24-115
Range on HMM: 1-90/90.0
PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDgSGSVLRIQPLrTPRDEAIYECVASNNVGEISVSTRLTV
|.||... |..   |  ... |...|.| |.. | |.|.......   ..... . . |.|.   ...|| .|.|.|.|..|. . ...|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnv.evsDeGkYtckatnsagkaeakaeLkV
subfamily_CG42327_pd Subfamily CG42327 1856-1923 1.2e-16 55.3 In-house 246-314 (319) alignment 
Range on Protein: 1856-1923
Range on HMM: 246-314/319.0
QDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
. ||. |||| ||||||. |.  | ....      ||| |.|  .| .|   |.| .||.| |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1357-1450 7.4e-16 52.1 In-house 5-95 (95) alignment 
Range on Protein: 1357-1450
Range on HMM: 5-95/95.0
IPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgipGSDYVNANYIDGYRKQNAYIATQG
| .  .  |.  ...| . .| .|. ||      ..     | | ||||. |.. || .|| |..      |||.|| ..||| ..|.|||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1692-1916 8.4e-16 52.9 In-house 22-251 (290) alignment 
Range on Protein: 1692-1916
Range on HMM: 22-251/290.0
KNRLVNIMpYESTRVCLQPIRGVEGSDYINASFIDgYRQQKAYIATQGPLAET-------TEDFWRMLWEHNSTIVVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |....        |.|| |  . ... |||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  ||   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFS
.    .   .| | . . .|.|| ||  ..... .. | 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1526-1630 9e-16 52.5 In-house 212-341 (350) alignment 
Range on Protein: 1526-1630
Range on HMM: 212-341/350.0
SEKREVRQFQFTAWPDHGVPEHPTPFLAFLR----------RVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE------RI----K----HEKTVD-
|.  .| |.|.  |.| ..  .|  .|  |             .  .   . |..||||||||||| .. .| .|.       .    .      || | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IYGHVTLMRAQRNYMVQTEDQYIFIHDALL
|   |  .| ||  |||. ||.|||..|||
isiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1683-1781 1.8e-15 51.2 In-house 90-181 (244) alignment 
Range on Protein: 1683-1781
Range on HMM: 90-181/244.0
SANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrekCHQYWPAE
 |  | | .|||    .|..  || |   .|  |  ||||||.    .   || || |||.|. |||.|. |    ..|.|  . |       .|||  
dafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1395-1630 2.2e-15 50.9 In-house 46-282 (302) alignment 
Range on Protein: 1395-1630
Range on HMM: 46-282/302.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEgipgSDYVNANYIDGYRKQNAYIATQGSLPET---FGDFWRMIWEQRSATVVMMTKLEERSRvKCDQYWP-
.    |  ||.  .| ..|. .| |.| .     .||||  ..    ..  | .|    ..     .||||..... ..||.. . || ..   ....| 
kafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk

-SRGTETHGLVQVTLLDtVELATYCVRTF--ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVID
 |   ...| . |     || |   .  .   .  .| |.   .    .| |... ||.. .   .    | . . .   ..|.    |.|| | |..  
ksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltla

AMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL
. .|.....| . |   |. .|.||  .|.. .||.... |||
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1862-1923 3.1e-15 50.3 In-house 2-63 (69) alignment 
Range on Protein: 1862-1923
Range on HMM: 2-63/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  |..| | . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1861-1923 3.3e-15 50.2 In-house 2-64 (69) alignment 
Range on Protein: 1861-1923
Range on HMM: 2-64/69.0
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
 ||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  | .| | . |  | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_hpo-7_pd Subfamily hpo-7 1736-1923 3.6e-15 50.6 In-house 42-226 (263) alignment 
Range on Protein: 1736-1923
Range on HMM: 42-226/263.0
AtqgpLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGV
     | .| . |....   ... ||||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .||...... |.|.  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKSGEGFIDFIGQVHKTKEqfgqdgpISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEY
|.  .  .  .  . . |.       . ||||.|.||.  |    .|  .|    .    . .|  . .. || .|.. ..|  |  ||    |..
pelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_CG42327_pd Subfamily CG42327 1565-1629 3.7e-15 50.4 In-house 246-311 (319) alignment 
Range on Protein: 1565-1629
Range on HMM: 246-311/319.0
DAGPMVVHCSAGVGRTGCFIVIDAMLERIKHE-KTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL
. ||.||||| ||||||  |  |  ......  ..|||   |  .| .|   |.| .|| ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1820-1923 3.7e-15 50.5 In-house 217-343 (350) alignment 
Range on Protein: 1820-1923
Range on HMM: 217-343/350.0
VRQFQFTDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE-------------RMRY-EGVVD-IFQTV
| |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.             .. .   . | |...|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KMLRTQRPAMVQTEDQYQFSYRAALEY
. || ||  |||. ||. | | |.| |
nelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1401-1628 1.2e-14 49.1 In-house 20-254 (290) alignment 
Range on Protein: 1401-1628
Range on HMM: 20-254/290.0
KPKNRYANVIAyDHSRVLLSAIEGIPGSDYVNANYIDgYRKQNAYIATQGSLP-------ETFGDFWRMIWEQRSATVVMMTKLEERSRV----KCDQYW
. ..|... ..  ..|| |        .||. ||..  . .  . |.||  .         |  .|| |. . ..  |||. . ||.|.      | .| 
emdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PSRGTE--THGLVQVTLLDTVELATYCVRTFALyKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKtCNppdAGPMVVHCSAGVGRTGCFIVID
| .  |  . . ..|   . ..     .|.  . | .  |.  |   ..  | .  |.|..  .|. .. || ..     |..|||  |. |  ..  |.
pesvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaii

AMLERIK-HEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA
     |   .. | .   .  .| ||. ..... .. |.  .
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag
I-set Immunoglobulin I-set domain 127-216 1.3e-14 45.8 Pfam-A 2-82 (90) alignment 
Range on Protein: 127-216
Range on HMM: 2-82/90.0
TIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDflpvD----TsnnNGRIKQLRSEsiggtpIRGALQIEQSEESDQGKYECVATNSAGTR
...  ..  .|.   .... | ..|.|.|...|.||    .    .   . |.|   .|       .  | |.. |.||.|||.|.||||||..
kftqklkdvevseGesvelectveGepepsvsWakd....gselks...sqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1564-1633 3.2e-14 47.5 In-house 226-295 (297) alignment 
Range on Protein: 1564-1633
Range on HMM: 226-295/297.0
PDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV
|   ...|||||||||.|  .  |..|.......  |.   .. .| ||  .||| .|. ...|| |. .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1688-1920 9.1e-14 45.7 In-house 46-275 (303) alignment 
Range on Protein: 1688-1920
Range on HMM: 46-275/303.0
CNKFKNRLVNIMPYESTRVCLQpirgveGSDYINASFIDGYRQQKAyIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA-RY
 |  |||.|...  . ..| |        | || ||...   ..|| | || ||. |. |||.|. | .   |..|    |. .   .  .| ..   ..
knmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

Q--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRTV-RQFQFTDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE
.  .  |  . . .. .     .||    .|. ..     .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .     
eersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RMR-YEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA
 .   .  .|. . ....|  |   ||   |. . |   
slhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1667-1739 1.2e-13 45.0 In-house 28-95 (95) alignment 
Range on Protein: 1667-1739
Range on HMM: 28-95/95.0
EFKR--LASSKAHTSRFISANLPcnkfKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGYRQQKAYIATQG
|||   ..|  ..|     ||.|    |||..||.||..|||.|   |    |||||| |.||| ....|||.||
efksismtsgapytvgsseanip....knrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 1406-1559 5.5e-13 43.0 In-house 57-208 (332) alignment 
Range on Protein: 1406-1559
Range on HMM: 57-208/332.0
YANVIAYDHSRVLLSAIEGIPgSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRG--TETHGLVQVT
  ... ||.  | |..    .   |.||  ..     . || |  .  .    ||.|. ||.| ..|.. .  |    | |.|.| ..     .| ..|.
vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

LLDTVELATYCVRTFALYKnGsSEKREVRQFQFTAWPDHGVPEHpTPFLAFLRRVK
  . |. . . .| . | | |  |  .|  ...  | .  .|     |||. . .|
rkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpky.edflalrkvmk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1402-1497 7.1e-13 42.6 In-house 50-161 (349) alignment 
Range on Protein: 1402-1497
Range on HMM: 50-161/349.0
PKNRYANVIAYDHSRVLLSA--------------IEGIPGSDYVNANYIDGY--RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKC
 |||| ... |.|||| |                 ..    ||.||||.       .. |||||  || |  ||...|  ..   |. ... .| |  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPSRGTETH
|.||     . .
diywqelsysni
subfamily_eak_pd Subfamily eak 1692-1843 8.3e-13 42.4 In-house 55-203 (332) alignment 
Range on Protein: 1692-1843
Range on HMM: 55-203/332.0
KNrLVNIMPYESTRVCLQPIRgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. | .|  .|.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSgEGFIDF
|    |. . . ||.  ..   .  ..  |  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1356-1438 9.2e-13 42.3 In-house 5-85 (440) alignment 
Range on Protein: 1356-1438
Range on HMM: 5-85/440.0
PIPILELADHIERLKanDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG
|| . ..||...  .      | .|.  .  | .   . ..|  || |||| |..|||||||.|  ..|.| |||.|| ||.|
piivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1400-1522 1.8e-12 41.4 In-house 34-157 (332) alignment 
Range on Protein: 1400-1522
Range on HMM: 34-157/332.0
NKPKNRYANVIAYDHSRVLLSAIEGIpgSDYVNANYIDGYRKQNAYIATQGSLPE-TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG
|   ||   . ..||||| |.  .|    |. ||...||| |..||| .|  . . |   ||||. |.. . ....  ..|. . |.      || |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

LVQV--TLLDTVELATYCVRTFALYK
| ..    |. .|| .  .| |   |
lhefgaksleecelkakicrkfwpek
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1692-1779 1.3e-11 38.4 In-house 51-154 (349) alignment 
Range on Protein: 1692-1779
Range on HMM: 51-154/349.0
KNRLVNIMPYESTRVCL----QPIRGVEGS----------DYINASFIDG--YRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| ..    .  .| ||||| ||  | .||....   .  .|. |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1707-1832 7e-11 36.5 In-house 11-125 (130) alignment 
Range on Protein: 1707-1832
Range on HMM: 11-125/130.0
ClqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILR
         | .||||||.    . . |. || |||.|. |||.|. |    ..|.|  . |       .|||       |.  ..  ... .  ..|  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdefknika

EF-KVTDARDGQSRTVRQFQFTDWPEQG
.. .. .      ...  || ..|| .|
snleiesdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1689-1773 1.2e-10 35.4 In-house 34-117 (332) alignment 
Range on Protein: 1689-1773
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYESTRVCLQPIRGVEgsDYINASFIDGYRQQKAYIATQGPLAETTED-FWRMLWEHNSTIVVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. |.. ......  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1437-1517 1.4e-10 35.1 In-house 230-308 (440) alignment 
Range on Protein: 1437-1517
Range on HMM: 230-308/440.0
DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSrvkCDQYWPSRG-TETHGLVQVTLLDTVELATYCVRT
.|| |.||.||||  |  |  ||||.. . | .|..|. .|....   |  |||    . | |   |    . ..    |||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1726-1805 2.9e-10 34.1 In-house 230-307 (440) alignment 
Range on Protein: 1726-1805
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  |  ||||.. ... . ..|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr
Ig_2 Immunoglobulin domain 133-223 3.7e-10 31.7 Pfam-A 8-78 (80) alignment 
Range on Protein: 133-223
Range on HMM: 8-78/80.0
QlKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNgrikqlrsesiggtpirgaLQIEQSEESDQGKYECVATNSAGTRYSAPANL
.  ||.   . |. |.|.|||.|...| ||  ....| |.                   | | . ...|.|.|.|.|.|| |   | . ..
p.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna...................lfipnvsaedsGtYtCrasnsegskqsnsvev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1852-1924 4.3e-10 33.4 In-house 260-344 (349) alignment 
Range on Protein: 1852-1924
Range on HMM: 260-344/349.0
EQFGQDGPISVHCSAGVGRTGVFITLSIVLE----------RMRYEGVV--DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL
 .  |  .. |||||| |||||..|| ..|.          .. .. .    |. .|  || || .|||   |. . | | |.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1668-1728 7.8e-10 32.6 In-house 28-86 (440) alignment 
Range on Protein: 1668-1728
Range on HMM: 28-86/440.0
FKRLASSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGY
.  | |. .. |    |.|| || |||  ||. |. .|| |. ..||  |||||||.|.| 
wsllpsglsqpsd..iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1529-1631 7.9e-10 32.6 In-house 218-342 (349) alignment 
Range on Protein: 1529-1631
Range on HMM: 218-342/349.0
REVRQFQFTAWPDHGVPEHPTPFLAFLRrVKT-----------CNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE----------RIKH-EKTVD-IYGHV
 |. |.|.  |.| ..   |  .|  |  ||             .  .  ...|||||| |||| .. .| .|.          .||   .. | |.  |
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

TLMRAQRNYMVQTEDQYIFIHDALLE
  .| ||  |||   |.|.|..|||.
nelrkqrismvqnlaqfiaiyealLk
fn3 Fibronectin type III domain 830-906 1.2e-09 31.3 Pfam-A 7-84 (85) alignment 
Range on Protein: 830-906
Range on HMM: 7-84/85.0
VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPlTTLEFSEKEDH--FTATDIHKGASYVFRLSARNKVGFGEE
 .  .. ... ..| || |  ||..||....  |. .   . ||. ....  .| |..  |..|.||. |.|..| |.|
svsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
I-set Immunoglobulin I-set domain 236-319 4.6e-09 28.0 Pfam-A 1-90 (90) alignment 
Range on Protein: 236-319
Range on HMM: 1-90/90.0
PRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNV----LELNDVRQ--SANYTCVAMSTLGVIEAIAQITV
|.|...... |.. | ||...| . |.| | |.|. . ..|...... .  .     |....|..  . .|||.|   .|  || |...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1679-1763 4.9e-09 30.2 In-house 27-116 (347) alignment 
Range on Protein: 1679-1763
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-----SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVML
|.| |..   .  |||  .    ..||| | | .   .       ||||| |     .| || || || .|  |||.|.   . | || .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
Ig_2 Immunoglobulin domain 38-115 6.7e-09 27.7 Pfam-A 14-80 (80) alignment 
Range on Protein: 38-115
Range on HMM: 14-80/80.0
GGVASFICQATGDPRPKIVWNKKGKKVSNQRFEviefddgsgsvlRIQPLRTPRDEAIYECVASN-NVGEISVSTRLTV
|    . |||.|.| ||. | |.|...|... .             ..|. .. |  .|.|.||| . .. | |...||
genvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_PTPDC1_pd Subfamily PTPDC1 1848-1915 6.8e-09 30.4 In-house 105-167 (182) alignment 
Range on Protein: 1848-1915
Range on HMM: 105-167/182.0
HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVlermrYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .| ..
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvel
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1682-1782 7.1e-09 28.8 In-house 20-88 (169) alignment 
Range on Protein: 1682-1782
Range on HMM: 20-88/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWEHNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpek

R
 
e
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1682-1781 9.3e-09 28.3 In-house 19-86 (169) alignment 
Range on Protein: 1682-1781
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWEHNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek
0038934 (Phosphotyrosine protein) phosphatases II 1828-1918 9.8e-09 30.6 In-house 85-171 (194) alignment 
Range on Protein: 1828-1918
Range on HMM: 85-171/194.0
W--PEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLE-RMryegvvDIFQTVKMLRTQRPAMVQTEDQYQFSYR
.  |..|.. | |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .  . ....|  || .... |...  ..
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1395-1474 2.9e-08 27.6 In-house 32-116 (347) alignment 
Range on Protein: 1395-1474
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEG-----IPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM
.. | .  |||  .|   | .||.||  .       .   |.|| .|     .. || ||  ||.|  |||.|.   . . || .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_eak_pd Subfamily eak 1553-1637 3e-08 27.4 In-house 225-309 (332) alignment 
Range on Protein: 1553-1637
Range on HMM: 225-309/332.0
AFLRRVKTcNPPDAGPmVVHCSAGVGRTGCFIVIDAMLERIKHEKT--VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGN
..|.. .   ||   | .. .. |  |.| |.||| ... |   |.    .   .  .. .|.. | .. |. ||....|. .   |
stlkkyih.tppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1385-1440 3.9e-08 27.2 In-house 24-78 (244) alignment 
Range on Protein: 1385-1440
Range on HMM: 24-78/244.0
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEgIPGSDYVNANYIDGYR
|  ..|    . | .|  |||| |.. .|..||.||. .   ||||.|||||.| .
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1422-1543 5.7e-08 27.1 In-house 7-125 (130) alignment 
Range on Protein: 1422-1543
Range on HMM: 7-125/130.0
IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrvkcDQYWPSRGT-E-THGLVQVTLLDTVELATYCVRTFA
.. ..| .|.||...    . . |. ||  | .|  |||.|. |.    .|..  .||      |.|||     |     . ||| |  |        . 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

LYKNGSSEKREVRQFQFTAWPDHG
  ..    .. .  || . ||  |
iesdlneshqaltmfqisnwpsdg
0038934 (Phosphotyrosine protein) phosphatases II 1536-1609 1.9e-07 26.4 In-house 84-156 (194) alignment 
Range on Protein: 1536-1609
Range on HMM: 84-156/194.0
FTAWPDHGVPEHPTPFLAFLRRVKTCNPPDA-GPMVVHCSAGVGRTGCFIVIDAMLeRiKHEKTVDIYGHVTLMR
   .||.|..      | ||. |.. .  |. |  .||| ||.||||....   .  |  . .  . ..... .|
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.r.lgmsaeeAialfrekR
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1395-1492 2.7e-07 23.7 In-house 22-87 (169) alignment 
Range on Protein: 1395-1492
Range on HMM: 22-87/169.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAnyidgyrkqnayiatqgslpetfgdfwRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR
..| .|. ||| |  .|  | || |  .    ||||.||                           |||||  .. .|..   ...     ...|| .
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek
Ig_3 Immunoglobulin domain 131-211 3e-07 22.6 Pfam-A 7-75 (75) alignment 
Range on Protein: 131-211
Range on HMM: 7-75/75.0
GPQLKVVERTRtATMLCAASGNP-DPEITWFkdflpvdtsnnnGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATN
 |.  |.. .   |  | | |.|  | |.|                 . .. | |  .. . | |.   ..| | |.|||.|
spsptvtsggn.vtLtCsaeggpppptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1395-1492 3.6e-07 23.2 In-house 21-86 (169) alignment 
Range on Protein: 1395-1492
Range on HMM: 21-86/169.0
SNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNAnyidgyrkqnayiatqgslpetfgdfwRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR
..| .|. ||| |  .|  | || |  .    ||||.||                           |||||  .. .|..   ...     ...|| .
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek
subfamily_PTPDC1_pd Subfamily PTPDC1 1521-1627 5.6e-07 24.2 In-house 73-170 (182) alignment 
Range on Protein: 1521-1627
Range on HMM: 73-170/182.0
YKNGSSEKREVRQFQFtAWPDHGVPEhPTPFLAFLRRVKTCnpPDAGPMVVHCSAGVGRTGCFIVIDAMlerikHEKTVDIYGHVTLMRAQRNYMVQTED
|.  .  ....  ..| .|.|.||.   .  |   . |. .   . | . ||| || ||||  |    .     . | ..    ..|.|..|   .|| .
Ydlealmeqgiyvynf.gwkDygvas.leriLdivkvvafa..lqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtre

QYIFIHD
|  ....
qvelvke
subfamily_PRL_pd Subfamily PRL 1847-1908 1.5e-06 22.4 In-house 80-135 (151) alignment 
Range on Protein: 1847-1908
Range on HMM: 80-135/151.0
VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEgvvdifQTVKMLRTQRPAMVQ
. |.| .   .  ..||| ||.||. |...|... . |.||      ..|...|..| . . 
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkye......davefirekrrgain
Ig_3 Immunoglobulin domain 26-102 1.7e-06 20.2 Pfam-A 4-75 (75) alignment 
Range on Protein: 26-102
Range on HMM: 4-75/75.0
FTRTPVDQTGVSGGvASFICQATGDP-RPKIVWNkkgkKVSNQRFEVIEFDDGSGSVLRIQPLRtPRDEAIYECVASN
 . .|   . ..|.  .. |.|.| |  |.| |     .  .. ..  |  ..|.|.| | .   . |   |.|||||
isvspsptvtsggn.vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvt.sedsGtYtCvasN
Ig_3 Immunoglobulin domain 235-305 2.4e-06 19.6 Pfam-A 1-74 (75) alignment 
Range on Protein: 235-305
Range on HMM: 1-74/75.0
PPRFSIPPTNHEIMPGGsVNITCVAVGSP-MPYVKWM-LGAEDLTPEDDMPIGRNVLELN--DVRQSANYTCVAM
.|  |..| ....  |. |..|| |.|.|  | . |.  .   | . ..  .. ..| .   .  .| .||||| 
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas
subfamily_CDC14_pd Subfamily CDC14 1857-1912 4.2e-06 20.8 In-house 263-313 (328) alignment 
Range on Protein: 1857-1912
Range on HMM: 263-313/328.0
DGPISVHCSAGVGRTGVFITLSIVlERMRyegvVDIFQTVKMLRTQRPAMVQTEDQ
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  |
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1443-1544 4.8e-06 20.4 In-house 137-235 (244) alignment 
Range on Protein: 1443-1544
Range on HMM: 137-235/244.0
NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERsrvkcDQYWPSR-GTETH-GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWP
  || ||  | .|  |||.|. |.    .|..  .||      |.|||     | .   . ||| |  |.       . .  .    .. .  || . ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV
  | 
sdgt
Ig_2 Immunoglobulin domain 242-310 5.1e-06 18.4 Pfam-A 6-71 (80) alignment 
Range on Protein: 242-310
Range on HMM: 6-71/80.0
PTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEddmpigRN--VLELNDVRQSANYTCVAMS-TLGV
... ..  | .|..|| | | | | |.| .. | |..       .|   . .  . .| .|||.|    .. 
apptvvtegenvtLtCqapgnptpkvqwykdgeelsqs......qnalfipnvsaedsGtYtCrasnsegsk
PTPc_motif_SM00404 1814-1909 7e-06 21.0 In-house 43-127 (140) alignment 
Range on Protein: 1814-1909
Range on HMM: 43-127/140.0
DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQT
  ..... | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||.. ... . ..... .||.. ..
ensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrq.lslaeayefvkerRpiispn