Gene PTPRF in Homo sapiens

Synonym: BNAH2, LAR, RP5-1029K14.1, PTPRF

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP097_AA protein Get Run
HsapP097_AA_1349-1624 phosphatase_domain Get Run
HsapP097_AA_1636-1915 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1344-1674 2e-169 559.9 In-house 2-333 (564) alignment 
Range on Protein: 1344-1674
Range on HMM: 2-333/564.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
..|||...|.. ...||||..|||..||..|..|||||||..| ..||.||||||..|||||||.|....|..|||||||..||||||..|||||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILA
||. |||||||||...|.||.|.||||..|||..|||..||||.| ..||| ...|||.|..||| |.|. |||.|| |||.|..||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
..|.|.|.|. ||||.||||||||||||.||||||||||.|.|||||||..|...|.|||.|||||.||.|||||.||| .||.|||...||..|.||| 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QVPPGESVTAMELEFKLLA-SSKAHTSRFISA
.| .....| .||||. || ... ....| .|
eveedtemtgleleFqrLatakeieleefava
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1347-1660 2.3e-131 432.6 In-house 2-317 (318) alignment 
Range on Protein: 1347-1660
Range on HMM: 2-317/318.0
IPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|.. ||.....||...  |..|.||| ...  ...|. .|. .||| ||||||..||||.|| |. ..|..||||||||||||||...||||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
. ||||||||| .|..||.|..||....|...||| .|... | ..|.| ..|||..|..|.| .......|.|. ||... .|||.|||| .. .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKACN-PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ
|.|.. . . .|||.|||||||||||| ||..|..|||.|.|..||... |. .|.||| ||||||||.||...|||| ..|.||| |..| ..|..| .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

VPPGESVTAMELEFKL
. |    | |..||. 
qdpesgttemdaefqr
subfamily_PTPRD_pd Subfamily PTPRD 1667-1919 8.4e-127 419.1 In-house 36-286 (564) alignment 
Range on Protein: 1667-1919
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|. .||.|....|.||||||||||.||||..||||||||||||..||||||.||.||..|||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||..|||.||.||..|||.......|.| .|....|   . |||.|||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH
....|||...|..||..|.||.||.||.||||||.||. ...| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1346-1659 1.5e-116 384.0 In-house 4-319 (319) alignment 
Range on Protein: 1346-1659
Range on HMM: 4-319/319.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
.|.. .|......|...   .. .|.. .. ....|..... | ||.|||| |..|||..||.|...|||.|||||||..||||......||||.|| .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAF
. ||||||||... .|||.|.| || .||. .|||    |. | . |||..  ||. | .| . |.| |.  | ||. .||...||||.|||. | .|..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
|.|..      ..||.|||||||||||| |||.||||||.|.| ..|..  |  .| ||| |||...|| ||.||||||...|.||.  ..|   ...| 
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QVPPGESVTAMELEFK
.  ..   | .| ||.
ekvadtgetglerefq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1652-1921 9.1e-114 374.8 In-house 20-287 (318) alignment 
Range on Protein: 1652-1921
Range on HMM: 20-287/318.0
TAMELEFKLLASSKAHTSRFISaNLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
. .. |.. |. |....... | . |.||.||| .||..|. ||| ||.. |.||||||||...||||..|||||.|.||.|  ||||||.|| ||..||
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdGPIT
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||..||...|.||..|||. | ...|...||.|.... |. |||.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..||||||||...| . ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_PTPRA_pd Subfamily PTPRA 1339-1658 9e-112 368.2 In-house 6-330 (330) alignment 
Range on Protein: 1339-1658
Range on HMM: 6-330/330.0
SSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA
|. . ..|.|. .| ..|.. .|.|  .| .|....     | | | .. | || |||. |.. ||.|||||. ..||. |||||| .||||.... .||
sgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSS----EKRELRQFQFMAWPDHG
.|||. ||. |||||.|||..||.||.| |.|. . || ||||  |. | | |.|.. |...|  |||| | ... . .    ..| .||| | .||| |
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

VPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPAR
||  |  .| .|..||..|.  |||.|||||||||||| |||.||.|||.| |. ||... |  .| ||  ||||. ||.||...|||    | ||. . 
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs

NLYAHIQKLGQVPPGESVTAMELEF
 |  |.||| .  .| . ...| ||
slekhlqklynkitgtdkigleeef
0040438 (Phosphotyrosine protein) phosphatases II 1349-1661 1.4e-111 368.0 In-house 2-314 (317) alignment 
Range on Protein: 1349-1661
Range on HMM: 2-314/317.0
ITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGD
..|| . ...|...|  ....|.| ..  .  |.. ..|..||.|||| ... ||||||.|....|...||||||.|.||.......||||||||.|..|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV
||||||||.. ..||.|.|||..|.||.|||| ..| |.| ..||||...||| .|.||. . ..|.||.|....|....|||||||..|...|.||..|
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPG
..... . ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|...||||  ....| .|| .|. ...|| .....
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

ESVTAMELEFKLL
..|. .| |.|||
ddvklkekelkll
subfamily_PTPRG_pd Subfamily PTPRG 1347-1635 1.6e-111 368.3 In-house 1-299 (563) alignment 
Range on Protein: 1347-1635
Range on HMM: 1-299/563.0
IPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGS-DYINANYIDGYRKQNAYIATQGPL
.|. ..|  .  |.|..  .||.|.|..      .... | |. . || |||| |..|||.||| |... |. .. |||||||||||.|..|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK----SGSS--EKRELRQFQFMAWPDHGVPE
..|. |||||.|||..|..||.| |.|. | |||.|||. ..||.| .|||| ..  ||.|||||. ...     ...  .... ||...  ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
...| | | .. .| |. .|||.|||||||||||| .||.|..|.....|..|...| .  .|.|||..||||.||.|.|.||||| . ..||. | ..
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
subfamily_PTPRK_pd Subfamily PTPRK 1344-1645 7.2e-110 361.7 In-house 1-299 (314) alignment 
Range on Protein: 1344-1645
Range on HMM: 1-299/314.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGqqftWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
|| | . || ..|  ||...|  | .||||.  |    |. .. . |. |||. ...|||.|||.|..||| | ||||||..||.|.. .|.|.|||||.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTEtCGLIQVTLLDTVELATYTVRTFALHK--SGSSEKRELRQFQFMAWPDHGVPEYPTPI
||. ||||.|.....|..||.| | |..|||| .|||  ..   | |.|.|..|  || . ||.|...|   | .|.||.|||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK
|...||||. .. .||..||||||| ||||.||.|| .|. ...|..||..  |  .||..  ||.||.||.||....|||. ||.| .|. .. |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LGQV
  ..
sirl
0051299 (Phosphotyrosine protein) phosphatases II 1344-1623 1.9e-108 357.6 In-house 2-286 (288) alignment 
Range on Protein: 1344-1623
Range on HMM: 2-286/288.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL
. .|....|.. ...|.||.  .. .|.| . . . ..|.  ..|. |..|||| ....||||||.|...|||.|||||||.|||||......|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS----GSSEKRELRQFQFMAWPDHGVPEYP
|.|..|||||||||.. ..||.|.|.|..|.||.|||| .|..|.| |.||||....|..|||||. . .     |..|.|. ..|....|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
...|.|||.|. ... . ||.||||||||||||.||..| .||....|..||... |  .|.||..||||..||.|..|||||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 1345-1624 1.2e-107 354.3 In-house 5-286 (293) alignment 
Range on Protein: 1345-1624
Range on HMM: 5-286/293.0
PPIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
 || ...... ....||.. |.||.|||..   |.. . . ..|.||. |||| |...|||||| |..... .||||||||||.||. .. .||||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR-GTETCGLIQVTLLDTVELATYTVRTFALHKsgSSEKRELRQFQFMAWPDHGVPEYPTPIL
||. ||||||||... ..||.|.| || .|||..||||   . . | |.|||. . ||  ...|.....|  ..|.|..||..|..|||||||| ....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKACN--PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT
.|.|.|.       ...|.|||||||||||| || .| .|.....| .|||.| |. .|..||..||||.||.|||...|.  .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0050432 (Phosphotyrosine protein) phosphatases II 1333-1627 1.4e-106 351.6 In-house 12-303 (308) alignment 
Range on Protein: 1333-1627
Range on HMM: 12-303/308.0
PSCPNTSSMRDHPPIPITDLADNIERlkANDGLKFSQEYESIDPGQQ-FTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGvPGSDYINANYIDGY--
. . .|| .  . .... ||.  .|.  |.|  ....|.| .   .  .... ..|. ||.|||| ....||||||.|    . .|||||||.|.|||  
llfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR---GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF
......||||||||.|..|||||||||.. ..||.|.|.|..|.||.||||     |....| ..||||.. .|..|||||. | ..|..| |....|..
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

MAWPDHGVPEYPTPILAFLRRVKACNplDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
..|||||||..|...|.||..|. ..  . ||.||||||||||||.||..| .||....|..||... |  .|.||..||||..||.|...|||| . . 
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

H
 
l
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1359-1630 3.2e-104 343.4 In-house 21-297 (298) alignment 
Range on Protein: 1359-1630
Range on HMM: 21-297/298.0
LKANDGLKFSQEYESIDPGQQ----FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVW
 |...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|...|.   |||||| ....|...||.||||.||.||. ||||||.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAcNPL
|.  .|.||.| |||. ..|. .||| .|.|| | |.|.|| . | | ..||.....|. ....||.||..|. |||.||||. | .|..||.|.| .. 
eedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

DAG--PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
.||  |..|.|||||||.| ||.||..|||.|.|..||..  |  .| .|  .||||.|||||.|| ||| ... .|.
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1650-1918 2.9e-101 333.7 In-house 21-287 (319) alignment 
Range on Protein: 1650-1918
Range on HMM: 21-287/319.0
SVTAMELEFKLLASSKAHtsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. | .| |||||  ...    | ||. . || |||  ||..|. ||| |... ||||||||||||.|||......||||.||.. .||||||.||..| |
getllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

IVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDG
.|||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.. .||.|.||...||... . .|......|..|.  |.|
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsg

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
||.||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||...||...| | ||.. ..|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0051299 (Phosphotyrosine protein) phosphatases II 1626-1914 3.4e-101 333.7 In-house 1-286 (288) alignment 
Range on Protein: 1626-1914
Range on HMM: 1-286/288.0
GHTEVPARNLYAHIQKLGqvppGESVTAMELEFKLLASSKAHtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYI
|.||.....|. ...||       ..| .. ||. | | ...   . .|.||.|. ||| ..|.||. .||.|... |||||||||||..|||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQ
|||||| ...||||||.||.|...||||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.|||...|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||| . | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||..||...|.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1346-1621 1.9e-100 331.2 In-house 1-275 (278) alignment 
Range on Protein: 1346-1621
Range on HMM: 1-275/278.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
||.. ||.. ...|..|.  ....|.|...  . .|.. ..|. ||.|||| ....||||||.|....|...||||||.|.|||......||||||||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPaRGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
..||||||||... |.||.|.|.|..||||.|||| .|..|.| ..||||.. .|..|||||. ... |..|.|. .......|||||||| ....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|. ... . ||..|||||||||||.||... .||....|..||..  |  .|.||  .|||..||.|..|||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 1367-1629 2.4e-100 330.8 In-house 2-280 (284) alignment 
Range on Protein: 1367-1629
Range on HMM: 2-280/284.0
FSQEYESIDPGQQF---TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYIDGY-----RKQNAYIATQGPLPETMGDFWRMVWEQR
. .|.| .   . .   ... ..|. |. |||| ....||||||.|.|.||  ..||||||.|.|||     ......||||||||.|..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TATVVMMTRLEEKSRVKCDQYWPARG-TETCGLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP--
. ..||.|.|.|..|.||.||||  | . |.| ..||||.. .  .|||||. | . | ..| |....|....|||||||..|...|.||| |. ...  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEK---TVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTE
 . ||.||||||||||||.||..| .||....|.   .||... |  .|.||..||||..||.|..|||||.. ...| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0050432 (Phosphotyrosine protein) phosphatases II 1649-1919 2.9e-100 330.9 In-house 39-304 (308) alignment 
Range on Protein: 1649-1919
Range on HMM: 39-304/308.0
ESVTAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGvEGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHN
 . . .| ||. | | |     . .|.||.|| ||| ..|.||. .||.|    . |||||||||. |||  ......||||||| ...||||||.||.|
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

STIIVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeq
...||||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.|||...|..|.||..|||   | ..||. .|.|.   
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

fgQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH
  ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||..||...|||.|||| .. .
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 1360-1638 1.4e-99 328.4 In-house 8-292 (297) alignment 
Range on Protein: 1360-1638
Range on HMM: 8-292/297.0
KANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT
|...  ....|.|...| . ..... ..|. |..|||| ....|||.||.|    . .|||||||.|.|||. ....||||||||.|..|||||||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

ATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVE--LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL
 ..||.|.|.|. |.||.||||    .. |.| ..||||.. .  |..||.||. . . |..|.|....|... ||||||||.|...|.|...|. ...|
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--DAGPMVVHCSAGVGRTGCFIVIDAMLERMK---HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
  . ||..|||||||||.|.||..| ||....   .|..|||.  |  .|.||. .|||..||.|..|||||   .. | .|...|. .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
0039614 (Phosphotyrosine protein) phosphatases II 1338-1627 6.4e-99 326.4 In-house 5-293 (297) alignment 
Range on Protein: 1338-1627
Range on HMM: 5-293/297.0
TSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQfTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYIDGYRK-QNAY
.... ...|||.. |.  . ..|||.  .. .|.|..   .   .. ..|..||.|||| ....||||||.|...||| ..||||||.|.|||.. ....
rdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

IATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTeTCGLIQVTLLDTVELATYTVRTFALHKsgSSEKRELRQFQFMAWPDHGVP
||||||||||..|||||||||.. ..||.|.|.|..| ||.|||| .|. |.| ..||||.. .|. |||||. . .  ..| |....||.. |||||||
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvp

EYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGH
.... .| ||. |. ..    . ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|...||||   ...
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 1361-1621 3.9e-97 320.2 In-house 8-270 (273) alignment 
Range on Protein: 1361-1621
Range on HMM: 8-270/273.0
ANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTA
...  .. .|.| . . . ..|.. ..|. || |||| ....||||||.|    | .|||||||.|.|||......||||||||.|..|||||||||.. 
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TVVMMTRLEEKSRVKCDQYWPARG---TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--
..||.|.|.|..|.||.||||  |   ..|.| ..||||.. . ..|||||. | ..|..|.|. ..|... |||||||......| |.. |. ..    
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
. ||.||||||||||||.||..| .|.....|..||..  |  .|||| .||||..||.|..|||||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 1341-1621 6.4e-97 320.2 In-house 3-302 (307) alignment 
Range on Protein: 1341-1621
Range on HMM: 3-302/307.0
MRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQF---TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYI--------DG
.  ...|....|   . .|....  .. .|.|.. . . |   ... ..|..||.|||| ....|||.||.|.|.||  ..||||||.|.        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKS-GSSEKRELRQFQF
|......||||||||||. |||||.|||.. ..||.|.|.|. |.||.||||  |.| |.| ..||||.. .|. |||||. .. . |..| |....|..
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

MAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .|||||||... ..|.|...|....    . ||..|||||||||||.||... ||.....|.|   ||..  |  .|.||  .||...||.|..|||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1354-1623 1.5e-96 317.8 In-house 10-279 (288) alignment 
Range on Protein: 1354-1623
Range on HMM: 10-279/288.0
DNIERLKANDGLKFSQEYESI-DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM
... . .|..   ||.||.|.   ... . . ..| ||..|||| |...||. || |.  . ..|.|||||.||||..|...||||||||..|..|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQRTATVVMMTRLEEKSRVKCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC
|.|..| |.||.| | |. . ||..|||. .. .  | ..|||... ||  ...|.. |.|.   ...|. |.|..|||||||||  .|.|..|| ||  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkva

NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
|. |.||..||||||||||| ||..||.......|...|. | |. .| ||. .|||. ||.||.|.||. .
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1626-1921 2.3e-96 317.6 In-house 1-297 (298) alignment 
Range on Protein: 1626-1921
Range on HMM: 1-297/298.0
GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKA--HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKA
| ||. |..| |..||| .| . ...| ..|||. | | .   ..     |. | || |||  .|.... .|| |. . . | |||||||||..|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGV
.||||.|| |..||||||..|.... |||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|..||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
|.. .  .|.. .|.....| | . |..|.|||||||.| || .. ||||.. | |||.||.||.||..||..||||.||  .| | ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0046845 (Phosphotyrosine protein) phosphatases II 1654-1917 5.5e-96 316.5 In-house 2-277 (284) alignment 
Range on Protein: 1654-1917
Range on HMM: 2-277/284.0
MELEFKLLASSKAHTS-RFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFLDGY-----RQQKAYIATQGPLAESTEDFWRMLWEHN
.| ||. | | . . .  .  |.||.|. ||| ..|.||. .||.|... |  |.|||||||..|||     ...|..||||||| ...||||||.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF
...|||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.|||...|..|.||..||| . | ...|. .|..  |..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEG---VVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
...||| |||||||||||.||.| ..||....||   .||....|| ||.||| ||||..||...|.|.|||| ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0040438 (Phosphotyrosine protein) phosphatases II 1652-1914 2.1e-95 314.9 In-house 18-276 (317) alignment 
Range on Protein: 1652-1914
Range on HMM: 18-276/317.0
TAMELEFKLLASSKAHtsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
||.. ||. | | | .   .  |.||.|| ||| ..|.||. .||.|.|. |...|||||||. ||.......||||||| ...||||||.||...|.||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPIT
|||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..|||...|..|.||..|||.. . ..||. .|..  |  ...||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||. .|.|.||||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1346-1642 8.6e-95 312.4 In-house 3-302 (305) alignment 
Range on Protein: 1346-1642
Range on HMM: 3-302/305.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGqQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
.| . |||  |.  ....  .. ..|.|.    . . .  . |.|| |||..... .|..|.|||  . .. ||||||.|.|||.....||..||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE--TCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPIL
. ||||...| .. |.||.|.| |  . || |||| . ||    | ..|.| .. . . |. | . . . ....|.| . |.|.  |||||||...| .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFLRRVKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK
 ...||.     | | |..||||||||||| ||..| .|||.|.|..||... .  .||.| .|||| |||||.|.|| |  |||.|..   || |...|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

L
|
l
0047943 (Phosphotyrosine protein) phosphatases II 1650-1914 1.3e-94 311.9 In-house 10-272 (273) alignment 
Range on Protein: 1650-1914
Range on HMM: 10-272/273.0
SVTAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
..| ...||.|| | |     .  |.||.|| |||  .|.||. .||.|    | .||||||||..|||......||||||| ...||||||.||.|...
gltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ
|||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.|||...|..|.||..||| . | ...|| .|.|. |.. .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.||. |||||||||||.||.| ..|.....|| ||....|| ||.||| ||||..||...|.|.||||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1657-1913 1.6e-94 311.5 In-house 37-294 (330) alignment 
Range on Protein: 1657-1913
Range on HMM: 37-294/330.0
EFKLLASSKAHtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | ... . . .  |.   || |||.|||.||. .|| |....||| ||||||||.|||.... .||.|||..|. ||||||.||..|. |||||.|
efnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdgPITV
.|  .|||.|||| | .  |    |    |  . .| .|.| |..     |. .|| .||| || ||. ||| .. | .... .|.|...| ..  ||.|
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivv

HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
|||||||||| ||.|. ||||.. |..||.|..|| ||.||| ||||. ||...|.. |||
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0039614 (Phosphotyrosine protein) phosphatases II 1650-1917 1.4e-93 308.9 In-house 30-292 (297) alignment 
Range on Protein: 1650-1917
Range on HMM: 30-292/297.0
SVTAMELEFKLLASSKAHtsrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNS
| | ..|||. | | |     .  |.||.|| ||| ..|.||. .||.|.|..|| ..|||||||..|||.. ....||||||| |..||||||.||...
sktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

TIIVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
|.||||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.|||...||.|.||. ||| . | ...|. .|..  .. ...
tvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||. .|.|.||.|  .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 1367-1622 5.3e-93 306.5 In-house 2-261 (263) alignment 
Range on Protein: 1367-1622
Range on HMM: 2-261/263.0
FSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
...|.|...  . . . .... . || |||| |.. |||.||.|..... .||||||||||.|..|...|||||||||.|. ||||||||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELA-TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
. ||. . |||.|||    |.|| | |.|.| .. .    ...||. | | | .|.|...|.|. .|||||||. ....|..|| || ..    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||||||.|..|| .|.....||.|||   |. .|.||  ||||..|| ||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1367-1622 5.3e-93 306.5 In-house 2-261 (263) alignment 
Range on Protein: 1367-1622
Range on HMM: 2-261/263.0
FSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
...|.|...  . . . .... . || |||| |.. |||.||.|..... .||||||||||.|..|...|||||||||.|. ||||||||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELA-TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
. ||. . |||.|||    |.|| | |.|.| .. .    ...||. | | | .|.|...|.|. .|||||||. ....|..|| || ..    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||||||.|..|| .|.....||.|||   |. .|.||  ||||..|| ||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0043336 (Phosphotyrosine protein) phosphatases II 1650-1914 6.4e-93 306.5 In-house 18-277 (278) alignment 
Range on Protein: 1650-1914
Range on HMM: 18-277/278.0
SVTAMELEFKLLASSKAhtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. |...|||. | | |     .  |.||.|| ||| ..|.||. .||.|... |...|||||||..|||......||||||| |..||||||.||...|.
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGP
|||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.|||........||..||| . . ..||. .|..  |   ..||
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
. |||||||||||.||.| ..||....|| ||....||.||.||| .|||..||. .|.|.||||
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1652-1917 1e-92 305.9 In-house 13-280 (297) alignment 
Range on Protein: 1652-1917
Range on HMM: 13-280/297.0
TAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
. .. ||. | . ..    .  |.||.|. |||  .|.||. |||.|    . |||||||||..|||......||||||| ...||||||.||.|.|.||
alllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
|||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.|||...|..|.||. ||| . . ..||| .|.|  ... ..
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

GPITVHCSAGVGRTGVFITLSIVLERMR---YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
||. |||||||||.|.||.. ..|....   .|| ||....||.||.||| .|||..||. .|.| ||.| ..
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0045450 (Phosphotyrosine protein) phosphatases II 1646-1914 2.5e-92 305.2 In-house 21-304 (307) alignment 
Range on Protein: 1646-1914
Range on HMM: 21-304/307.0
PPGESVTAMELEFKLLASSKAH-TSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFL--------DGYRQQKAYIATQGPLAEST
 . ...| .. ||. | | . .    . .|.||.|| ||| ..|.||. |||.|... |  |.|||||||.         |||......||||||| |. 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

EDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDF
|||||||||...|.|||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.|||...|..|.||..|||.. | ..||
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

IGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||...||. .|.|.||.|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1389-1625 4.9e-92 302.6 In-house 8-244 (250) alignment 
Range on Protein: 1389-1625
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVkCDQYWPARGTETCG
 || |||||..||.|.|||.| . .|   |||||| ...||....|.|||||||..|. ||||||.|. ..|.||.| |.|. .. . ||||. ..|. |
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL-DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEK
 ..|.||.. | | ||.|.. | |   ...| .||..|..||| ||||. | .|..|..|.| ..  ...|..|.|||||||.|.||.|||.|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
.||..  .  .| .|  .|....||||..|..|.| ..
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1366-1642 5.2e-92 303.5 In-house 35-310 (319) alignment 
Range on Protein: 1366-1642
Range on HMM: 35-310/319.0
KFSQEYESI--DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVM
|.  |.  .   . .  . . .||. || |||. |..|.|...| |  ..|. .|||||| ...||.... |||.||||..|. |||||.||....|.|.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

MTrleeksRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD--AGPMV
.|      . || |||| .. .. .  .| .    | | |.|| . | . .   ..|...|| |. |||.|||.||.... ....|.  .       ..|
lt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKL
||||||||||| .||.|..|.|||.|| ||.|  |  .| ||| .||   || ||. ||||    ||..|   .. |....|
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1344-1638 8e-92 302.5 In-house 3-293 (315) alignment 
Range on Protein: 1344-1638
Range on HMM: 3-293/315.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
| |||. .|   . . ||.    | |.||||  || .  . ..   || |||| |.||||.||| |  ..  |.|||.|||.|||| |.. |||.|||..
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARgTETCGLIQVTLLDTVELATYTVRTFalHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILA
....||||.|.|.  ...||.| | |. . |...||| .   . | | ||. .      |||||.       .. ||. |... .||| |||.| .|.. 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmn

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVpARNLYAH
. |.||  .  ..|..|||||||||||| || .||.|.... |. .|.|  .| .|..|  |||. .|| ||..||||.  || | . |..|| .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdlylq
0040439 (Phosphotyrosine protein) phosphatases II 1381-1621 1.4e-90 298.5 In-house 2-244 (249) alignment 
Range on Protein: 1381-1621
Range on HMM: 2-244/249.0
TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP
... ..|..||.|||| ....||||||.|....|...||||||.|||||. ....||||||||||..|||||.||..  ..||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDA
 .|. ..| ..||||.. ... |||||. |.... .|.|. ...|.  |||||||... ..|.|...|. ..    . ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
|||....|..||..  |  .||||...||...||.|..|||||
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1382-1642 2.2e-90 298.0 In-house 17-274 (284) alignment 
Range on Protein: 1382-1642
Range on HMM: 17-274/284.0
WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTrleeksRVKCDQYWPA
 . .||. || |||. ...|.|...| |  ..|. .|||||| .| ||.... ||||||||..|. |||||.||....|.|..|      . || |||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

RGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD--AGPMVVHCSAGVGRTGCFIVIDA
.. .. .  .| .    | . |.|| . | . .   ..|..||| |. |||.|||.||.........|.  .       ..|||||||||||| .||.|.
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKL
.|.|||.|| ||.|  |  .| ||| .||   || ||. ||||    ||..|   .. |....|
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0040439 (Phosphotyrosine protein) phosphatases II 1672-1914 7.3e-90 296.1 In-house 4-246 (249) alignment 
Range on Protein: 1672-1914
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||. .||.|....|...|||||||..|||......||||||| |..|||||||||...|.|||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.|||....|.||||..|||.. | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|....|. ||....||.||.||| .||...||. .|.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 1657-1914 4.4e-89 293.7 In-house 5-262 (263) alignment 
Range on Protein: 1657-1914
Range on HMM: 5-262/263.0
EFKLLASSKAHTsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | .|. .. .. .|. . || |||  ||.||. ||| |... . ||||||||....|....|.|||||||| .  |||||| ||....||||||. 
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

REMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDGPITVH
 | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|...|.|...||..|||.. . ..... .|.|.|..   .||| ||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVh

CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||.|.|..|.|.... |  ||.|..|| ||.||| ||||..||. .|.|.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1657-1914 4.4e-89 293.7 In-house 5-262 (263) alignment 
Range on Protein: 1657-1914
Range on HMM: 5-262/263.0
EFKLLASSKAHTsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | .|. .. .. .|. . || |||  ||.||. ||| |... . ||||||||....|....|.|||||||| .  |||||| ||....||||||. 
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

REMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDGPITVH
 | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|...|.|...||..|||.. . ..... .|.|.|..   .||| ||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVh

CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||.|.|..|.|.... |  ||.|..|| ||.||| ||||..||. .|.|.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 1390-1621 6.3e-89 292.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 1390-1621
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILtsiDGVPG-SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP--ARGTET
|| |||| ....||..|| |   .| .| ||||||||..||......|||||||..|..|||||||.... ..||.|.||||.|.||.||||   ....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGLIQVTLL-DTV-ELATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM
.| |.|.|  ..  . . ||.|.. |.|.... ||||..|... .|||||||| |...| ..|.|.  .  . ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|..||..  |  .|.||. |||...||.|...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1390-1621 6.3e-89 292.8 In-house 1-235 (235) alignment 
Range on Protein: 1390-1621
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILtsiDGVPG-SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP--ARGTET
|| |||| ....||..|| |   .| .| ||||||||..||......|||||||..|..|||||||.... ..||.|.||||.|.||.||||   ....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGLIQVTLL-DTV-ELATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM
.| |.|.|  ..  . . ||.|.. |.|.... ||||..|... .|||||||| |...| ..|.|.  .  . ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|..||..  |  .|.||. |||...||.|...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Ptp69D_pd Subfamily Ptp69D 1345-1642 9.3e-89 292.6 In-house 2-305 (307) alignment 
Range on Protein: 1345-1642
Range on HMM: 2-305/307.0
PPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
..|.| ||.....  | .    . .|||..     . . ..|. . |. |||| ...|.|. ||.|. | |   ||||||..| ||.... .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSG-----SSEKRELRQFQFMAWPDHGVPEYP
.|.||||||..||   ..||.. |.||.| ||..|||   .   | | |.| .. .   |. |.. . | .       ..|.. |.....|.|  ||| .
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
. .| ....|.  . |. .|.||||||||||.| |. .| .|...| |..|||.  |  .||||| .||  .||||.. |||.  . |.|..  ..|  .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKL
|..|
ierl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1353-1622 2.5e-88 290.9 In-house 3-275 (281) alignment 
Range on Protein: 1353-1622
Range on HMM: 3-275/281.0
ADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWR
  ....|..||   | .|||..   |.. | . |. . |. |||| |..|||..|| .|  .    .||||||...||.....|||||||.|... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQRTATVVMMTRLEEKSRVKCDQYWPARG-TETCGLIQVTLLDTVELATYTVRTFALhKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA
|||||.  ..||.||  |....|| .|||    . . | ..|. . . | |||  |.| | .  |.|.||..|....||||||||. .. .| | . |. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

CNPLDA-GPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
..  .   |.|.||||||||||..| .| .......| ...|.   |. .| .||.||||  || |.. |.|.|
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
0042113 (Phosphotyrosine protein) phosphatases II 1383-1621 2.6e-88 290.8 In-house 2-241 (245) alignment 
Range on Protein: 1383-1621
Range on HMM: 2-241/245.0
ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR
. ..|..||.|||| ....|||.||.|....| ..||||||.|.||||  . .|||||||||| .|||||.||..  |.||.|..||..||||.|||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLE
.. |.| ..||||..  |..|||||. ... |..|.|| ...... |||||||...  .| ||..|. .    . ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
....|..|...  |  .||||  .|||..||.|..|||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1369-1624 2.8e-88 291.1 In-house 12-273 (278) alignment 
Range on Protein: 1369-1624
Range on HMM: 12-273/278.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVIltsidgvpgsDYINANYIDGYrkQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLE
. .. . .|.  ........ |..|||| ....||||||.          |||||.|||||  ....||||||||.|. |||||.||... ..||.|.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS----GSSEKRELRQFQFMAWPDHGVPEYP--TPILAFLRRVKACNPL--------
|..|.||.|||| .|..|.| ..||||.. .| .||.||. ..       . |.|........ |||||||..|  ...| .|....... |        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----DAGPMVVHCSAGVGRTGCFIVIDAMLERMkhEKTVDIYGHVTCMRSQRNY-MVQTEDQYVFIHEALLEAAT
     . ||..|||||||||||...... |||..  |..||..  |. .||||.. .||...||.|..|.|||   
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRB_pd Subfamily PTPRB 1657-1914 1.9e-87 288.0 In-house 30-285 (293) alignment 
Range on Protein: 1657-1914
Range on HMM: 30-285/293.0
EFKLLASSKaHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
|.. | . . ..    .|.|..|. |||  ||.||. .|| |..... .|||||||....||.... .||||||| |...|||||.||..|.||||||.|
eyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

REMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCS
 | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|..||..|| ||. |||.. . ..||. .|....|.  ...||.||||
vekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCs

AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||.||.|  .|.... | .||.| .|  ||..|  .||||.||   ... |..|
aGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN9_pd Subfamily PTPN9 1367-1623 2.2e-87 287.9 In-house 18-290 (297) alignment 
Range on Protein: 1367-1623
Range on HMM: 18-290/297.0
FSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
 |.||. |     . | ..|.| .|  ||||..|. ||..|| |...|. . |||||||..|||....|.|||||||..|. |||||||||.. ..||.|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

RLEEKSRVKCDQYWP--ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC------------
|..|. |.|| ||||     ..  | ..|. ....|   |.||.. ....  .|.|..  |||..|||.|||.  . .| .|. |.              
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdew

-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
  ...  |.|||||||.|||| || .|  |.|.... |||.   |  .|.|| ...||..||.| . |.|| |
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1651-1918 6.9e-86 283.1 In-house 21-287 (305) alignment 
Range on Protein: 1651-1918
Range on HMM: 21-287/305.0
VTAMELEFKLLASSkaHTSRFISANlPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
 ...| ..|.|..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .  .||||...|   . |
dkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQD
||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||. |.|.||||..|||..   ....| .|.|.... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
 |..||||||||||||||...| |||.. |.|||.|. .|.||..|. |||| |||. .. |  |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0045098 (Phosphotyrosine protein) phosphatases II 1654-1915 1.2e-85 282.5 In-house 11-273 (278) alignment 
Range on Protein: 1654-1915
Range on HMM: 11-273/278.0
MELEFKLLASSKahtSRFISANLPCNKFKNRLVNIMPYELTRVClqpirgvegsDYINASFLDGYrqQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.| ||.|| ..    |..  |....|. ||| ..|.||. .||.          ||||||..|||  .|..||||||| . ..||||||||...|.||||
lefefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivml

TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKTG--EGFIDFIGQVHKTKE-----
|.| |.|||||.|||| . | .|  |.|  . |.... |.|| ..||.      |..||........ ||. ||| .     |.... ....  .     
telvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

------QFGQDGPITVHCSAGVGRTGVFITLSIVLERMryEGVVDMFQTVKTLRTQRPA-MVQTEDQYQLCYRAALEYLG
      .....||. |||||||||||... . ..||..  ||.||....||.||.|||  .||...||. .|...||.| 
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 1674-1914 1.8e-84 278.2 In-house 4-243 (245) alignment 
Range on Protein: 1674-1914
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||. |||.|.|. | ..|||||||. ||||. . .|||||||.|..|||||||||...|.|||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.........||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
...|. |.....|| || ||| .|||..||. .|.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRG_pd Subfamily PTPRG 1652-1916 1.9e-84 278.9 In-house 19-289 (563) alignment 
Range on Protein: 1652-1916
Range on HMM: 19-289/563.0
TAMELEFK-LLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGS-DYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. .. ||. |   .....    ... |.|| ||| .||..|. .|| |.|. |.... |||||...|||...||.|||||||.. ..|||||.||.|..|
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQ
|||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ...||...|.||..|||.     . |. .  .....
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

fgQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
  . |||.|||||||||||..| |. .|.... | .|..|...|..|.||. .||||.||.  . | || . |
..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN9_pd Subfamily PTPN9 1665-1914 7e-84 276.4 In-house 28-290 (297) alignment 
Range on Protein: 1665-1914
Range on HMM: 28-290/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC
.. . .|  ..|..|  |||  ... |. ||| |. . . | ||||||.|.|||.|.||.||||||| . ..|||||.||..  .||| |.. |.|| ||
epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkc

HQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFG-----------QDGPIT
 ||||   | ||..  . |  .   .. .|  | ..........||..  |||. ||. |||.... ..|.. .| ... ..            .. || 
gqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||..||..|| | ||| 
vhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1675-1921 1.3e-83 275.1 In-house 5-249 (250) alignment 
Range on Protein: 1675-1921
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|.... .|| |.. .| . |||||||||.||...||.||||||| ...||||||..|..|. |||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|..||..|. ||..|||.. .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
. | |||.|. .|.||..|| .|....||  .|...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_PTPN6_pd Subfamily PTPN6 1365-1620 1.8e-83 275.0 In-house 26-294 (306) alignment 
Range on Protein: 1365-1620
Range on HMM: 26-294/306.0
LKFSQEYESI---DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTsIDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTA
  |..|.|..   .  .... ....   || |||| |.. .||.||||.  ..||||||||||||..    ....|||||| |..|. |||||||.. . 
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TVVMMTRLEEKSRVKCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC----NP
 .||.|.  |... || .|||.  . |. | |.|| ..  .||.|..|.. . .|. ..|.||..|..| .|||||||. |  .|.||. |..     . 
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE---KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
 .|||.|||||||.|||| |||||..|. ....     .||.  |  .|.||. .||||.|| |...|. 
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1649-1913 1.3e-82 272.7 In-house 31-291 (319) alignment 
Range on Protein: 1649-1913
Range on HMM: 31-291/319.0
ESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST
. .| .| ||. ..   .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .. .|||||.||.|..
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IIVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
 ||.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | |.|| |  ||..|||. .  .. .. .|.. ...  . 
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE-Y
 .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||...| | || .
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
Y_phosphatase Protein-tyrosine phosphatase 1679-1912 8e-82 269.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 1679-1912
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYELTRVCLqpiRGVEG-SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||. ||| |   .| || ||||||....||...|..||||||| .. ||||||.|......|||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|...|...|.||..|||.. ....|.| .|.|.|    ..||..|||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
... |. ||..|.||.||.||| |||...||. .|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1679-1912 8e-82 269.5 In-house 1-235 (235) alignment 
Range on Protein: 1679-1912
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYELTRVCLqpiRGVEG-SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||. ||| |   .| || ||||||....||...|..||||||| .. ||||||.|......|||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|...|...|.||..|||.. ....|.| .|.|.|    ..||..|||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
... |. ||..|.||.||.||| |||...||. .|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRK_pd Subfamily PTPRK 1678-1912 1.9e-81 268.3 In-house 42-275 (314) alignment 
Range on Protein: 1678-1912
Range on HMM: 42-275/314.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSArYQ
 |. |||  .|..|. .|| |..| |   ||||||...|.|.. .|.|.||||| | ..||||.....|.. |||||.| | || || .||| . .  |.
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

YFVVDPMAEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRTGVFITLSIVLERMR
 . |  .      ... | |.|. .  |  . |..|||||. ||. .||.  .|..... .|.|..|.  ..|.| |||||| ||||.||...|||. ..
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 |||||.|..|||||.... ||.||.||...| ..||
regvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1650-1911 2.1e-81 268.1 In-house 19-276 (288) alignment 
Range on Protein: 1650-1911
Range on HMM: 19-276/288.0
SVTAMELEFKLLASSKAHTSRfISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. | .. |.. ||. . . |    ..|. |. |||  ||.||. .|| |.    ..|.||||||..||....|.|||||||||.. .|||.. .|.... 
nrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDG
|||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ..| |.|.. ||..|||.  . ..... ||. ....    |
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tg

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
||.|||||||||||.||.|  ...... | ..|.. ||. || ||. .|||. ||. .|.. |
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN12_pd Subfamily PTPN12 1378-1622 4.9e-81 266.8 In-house 28-276 (290) alignment 
Range on Protein: 1378-1622
Range on HMM: 28-276/290.0
QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
.... |... |.|. |||| ... ||.||| |. |....||||||||.| |  .. .|||.|||||.|. |||||.||...  |||. |. |  . ||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPARGTETC--GLIQVTLLDTVELA-TYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFI
||| .| |..  | ..||| .   .   ...||......  .|.|...||...||||||||. ....|.... |.  .  .. |.||||||||||||  |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.|| . | .|.||.   .|..  |. .| ||. .|||..||.....|..| 
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Ptp69D_pd Subfamily Ptp69D 1654-1914 6.5e-81 266.8 In-house 24-286 (307) alignment 
Range on Protein: 1654-1914
Range on HMM: 24-286/307.0
MELEFKLLASSKAHTSRfISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.. |.. | ... . |    ..   |..|||  .|.... ||| |..| | | ||||||||. ||...| .|| |.|. .  .|||||..| ..|.||||
lakeyekLeareidkst.kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDG
..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| . |...| |..  ||.. .| ...| ||.. ...    .
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rs

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||.|||||||||.|.|..|...|.... |  ||.|.||| || ||. .||  .||. .||| |.| 
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
0037934 (Phosphotyrosine protein) phosphatases II 1382-1621 8e-81 266.4 In-house 2-240 (243) alignment 
Range on Protein: 1382-1621
Range on HMM: 2-240/243.0
WENSNLEVNKPKNRYANVIAYDHSRVILtsidgvPGSDYINANYIDGYRKqnaYIATQGPLPETMGD----FWRMVWEQRTATVVMMTRLEEKSRVKCDQ
.  ..|..|..|||| ....||||||.|      .||||||||.|.....   .||||||||||  |    ||||.||... ..||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWParGTETCGLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--------NPLDAGPMVVHCSAGVG
|||  |..|.| ..||||.. .|. |||||. |   . . ..|. .......|||||||. |...|.||. |...        .  . ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERMkhekTVDIYGHVTCMRSQRNY-MVQTEDQYVFIHEALLE
|||..|... ||...    .||..  |  .|.||.. .|||..||.|..|||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1346-1659 1.1e-80 265.8 In-house 2-313 (315) alignment 
Range on Protein: 1346-1659
Range on HMM: 2-313/315.0
PIPITDLADNIErlKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|||....   ..  |      ||.|.  .   . .    .  ..| .|||| |.. .|..||.|  ||  | |||||| || .. ...||||.||||. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE--TCGLIQVTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILA
. ||||||......|.||.| ..|  ..|| |||| | ..    | |.|.||..   .  ..| . . ||   |.| . ||||  |||.||..  . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllk

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
... ||| |  .  ...||||||||||| .| || .....|....||..  |. .|..| |.||||..| ||..|.||      | ..  ..  |.| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QVPPGESVTAMELEFK
    |.  . |  ||.
tsvdgsgrskmtkefe
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1656-1913 2.4e-80 265.1 In-house 2-255 (284) alignment 
Range on Protein: 1656-1913
Range on HMM: 2-255/284.0
LEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTk
 ||. ..   . ..    |||. || |||...|.... ..| |... |.|.||||||||. ||.... |||||||| .. .|||||.||.|.. ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

lremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHC
     ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |.|||| |  ||..|||. .  .. .. .|.. ...  .  .| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE-Y
|||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||...| | || .
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1365-1663 1.3e-79 262.7 In-house 18-316 (515) alignment 
Range on Protein: 1365-1663
Range on HMM: 18-316/515.0
LKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
  ||.|.  .   . .    .. |.| .|||| |.. || .||.|  |.  | |||.|| || ..  ..||||.|||.. .. ||||.|......|..|.
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TRLEEKSRVKCDQYWPARGTET--CGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
|.|.|  ..|| .||| . ...   | |.| |. .   .  . |.. . |.     | . ||.|  |||.|||.  . .| ... ||| .   . |...|
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLA
||||||||| .| || .. ..|  ..||..  || .| .| |.|||..|| ||..|.||      | .|   .  |.| |     |.  . |  ||. | 
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

S
|
s
subfamily_PTPN6_pd Subfamily PTPN6 1652-1914 3.4e-79 261.0 In-house 26-297 (306) alignment 
Range on Protein: 1652-1914
Range on HMM: 26-297/306.0
TAMELEFKLLASS-KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNST
. .| ||. |  . . ..     .. | || |||  ||.|.. ||| |.   .| |||||||.....    ..|.|||||| | .  .|||||.|. ||.
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

IIVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFG-
.|||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|...|..|..||..||||  . ..||. .|.. .|..  
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

-QDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 . ||| ||||||.|||| || . |.|. ....|.   .|. ..||..|.||  .||||.||.. |.|  .|.
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1347-1658 6.6e-79 260.4 In-house 5-323 (325) alignment 
Range on Protein: 1347-1658
Range on HMM: 5-323/325.0
IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETM
| . .| ...|. ||.|   |..|.. . . .  . . . .  || |||. ||.|.|.|||.| . .  | ||||||.|.  ..|.. ..|.| ||..|.
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMVWEQRtATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAF
.|.||.| . | ..||...   ..   .| .||| .   . | | ..| |    |.. |  | . . .    | | ..|||...|.| ||...|. ....
ndlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKAC------NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
|. |||       |   ..|..||||||||||| || . ..|... .|  |||.| |  .| .|  ||.| |||..|.||| ||  .| |.||  .. |.
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLGQVPPGESVTAMELEF
.  | .  |      .| ||
lsslqernpltqklniekef
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1388-1622 1.7e-78 258.1 In-house 5-239 (239) alignment 
Range on Protein: 1388-1622
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET
 ||| ||||||...||||||.|  .   | ||||||.|.  |    .||||||| .  . ||||||.|..| . .||.| | |  . || ||||   .. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

CGLiQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE
| | .|||  |  .| | .||| . . | .|.| . |..|  |||.|||.| | .| . |..   .   | | |.||||||||||.|.|||||| . |..
cnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||. .| ..| .| .|||| .|||||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1386-1621 4.4e-78 256.7 In-house 4-239 (239) alignment 
Range on Protein: 1386-1621
Range on HMM: 4-239/239.0
NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGT
.  ||| ||||||...||||||.|  .   | ||||||.|.  |    .||||||| .  . ||||||.|..| . .||.| | |  . || ||||   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

ETCGLiQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK
. | | .|||  |  .| | .||| . . | .|.| . |..|  |||.|||.| | .| . |..   .   | | |.||||||||||.|.|||||| . |
kycnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|||||. .| ..| .| .|||| .|||||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN12_pd Subfamily PTPN12 1673-1914 1e-77 255.9 In-house 34-277 (290) alignment 
Range on Protein: 1673-1914
Range on HMM: 34-277/290.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE-
... . |. |||  .|.||. .|| |. |...||||||||.|. |  ....|||.||||..  .|||||.||.| .|.||. .. |.|. ||..||| | 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

-RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSI
 .. ... | |. ..| ..  ....| .||.    ..||...||..|.||..|||.. .  ...| .|....|   .| |. |||||||||||. |.. .
eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidy

VLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| | .. | .   .|.|. | .||.||.|.|||..||.| |.| .|..
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1655-1920 3.7e-77 254.0 In-house 23-289 (290) alignment 
Range on Protein: 1655-1920
Range on HMM: 23-289/290.0
ELEFKLLASSKAHTSrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM
. .|| | |.. . .    .. . || .||  ||..|.  |. |.|| | .    .||||....||...|.|||||||. .   |||...|....|||||
rnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPIT
||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |..... |.|.| |...|  .  .. .  | .. ||. . | ...| 
ltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
||||..|||..||... . ..... |||.|.|| .|..|.|.| .|||..|||. ..  |.|| ||. |
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN13_pd Subfamily PTPN13 1383-1622 8e-77 253.2 In-house 30-268 (273) alignment 
Range on Protein: 1383-1622
Range on HMM: 30-268/273.0
ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsdYINANYIDGYRKQ--NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP
| .. . || |||| ||. ||..||.| .  |     ||||..|     .    |||.|||||||. |||.|||||..  ..|.|   || .|||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

ARGTETCG---LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPlDAGPMVVHCSAGVGRTGCFIVID
 .  ..      ..|.||....| ...||..|...| |.| ||. ...|..|||||||  ....| |...|.  .  ||||.|||||||.||.| .|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
..|. ....| .|.   | ..| ||. .|||.|||.|...|.||.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
0037934 (Phosphotyrosine protein) phosphatases II 1673-1914 1.9e-76 252.1 In-house 4-242 (243) alignment 
Range on Protein: 1673-1914
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYELTRVCLqpirgvEGSDYINASFLDGYRQqkaYIATQGPLAESTED----FWRMLWEHNSTIIVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||.. .....   .||||||| |..||    |||||||...|.|||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQ------FGQDGPITVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|........ ||..||| . | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDMFQTVKTLRTQRPA-MVQTEDQYQLCYRAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||..||. .|.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1673-1914 2.7e-75 248.1 In-house 35-276 (281) alignment 
Range on Protein: 1673-1914
Range on HMM: 35-276/281.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER
... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .| ..||.|.||.. ..|||.|.  | |. |||.||| ..
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdGPITVHCSAGVGRTGVFITLSIVL
 . .|  ..|  .|| . ..|| |.||. ....|..|...|...| ||..|||.| . ...|  .|.|..|.  .  |. .||||||||||..|.|  ..
selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

ERMR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
...   .  .|. ..|. || .|  ||||  ||.  |.| |..|
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1342-1633 8e-75 246.7 In-house 5-294 (297) alignment 
Range on Protein: 1342-1633
Range on HMM: 5-294/297.0
RDHPPIPITDLADNIERLKANDglKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKqnAYIATQGP
..  |||..|.|  ... .  |   ||.|.  .   . ..   ..  || .|.||.|.. || |||.| ...  | |||.|| .. |...   .|.|| |
kerrpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPE--YPT
 ..|. |||.||......|.||.. ..|. . || .||. .|. | | . |.|| . |   .  |.. . |. .  .| ..|.||. |||. |..    .
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

PILAFLRRVKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPAR
 .| ..  |.      |  |..|||.||||||| .. || .. ..|.||.|||.| |. .| .| |.|||..|| |...|.|||  . .|...| 
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1380-1621 4.7e-74 243.9 In-house 18-266 (274) alignment 
Range on Protein: 1380-1621
Range on HMM: 18-266/274.0
FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG-SDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
|. |. ..  .. |||| ...  ..|||.|.| ..    |.||||||| ||.. ..||.|||||||.|. |||||......  .||.|.|.|. . || .
fdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPARG----TETCGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACN---PLDAGPMVVHCSAGVGRT
|.| .     .|. | ....  ..||   |.||.. |... .  .|..  . . .|||| .|. ....| ... |.  .      ..|.|||||||.|||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
|||| |.  . ....|..||. . |. .| .|  ||||..|| .||.|| .
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1347-1625 9.4e-74 242.9 In-house 2-285 (290) alignment 
Range on Protein: 1347-1625
Range on HMM: 2-285/290.0
IPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLP
||. .... ..  .|.   .| ......| |. ..| .  . . ||..||.||.. ||  |..|  | | .    .|||| ||.||.....|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHG-VPEYPTPI
.|. |||...|..... .||.|   |. .||| ||||...|.. | ....||.  .| .|. |.. .... |  .|... |.|. .|...| |... | .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
|.. ...|       ...|||||..|||.. |....  ....| |  .|..  .  .|.|.  .|||..|| .|.. .|.. ..
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN3_pd Subfamily PTPN3 1381-1623 2.1e-73 241.7 In-house 32-275 (280) alignment 
Range on Protein: 1381-1623
Range on HMM: 32-275/280.0
TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYID----GYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
. .....  | .|||| ....||. ||.|.. .     |||||||..    .    | ||||||||..|. |||.|||||.. ..||.| | |. |||| 
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPARGT-ETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
||||  .   . | ..|..  . |  .| .| . |... ..|.|.. |.|..||||||||. .. .| |..||...   .  |.|||||||.|||| .|.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
..  |  . ... | .   |  || ||  .|||..|| |. ||.|.. 
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1351-1630 4e-73 241.3 In-house 6-286 (439) alignment 
Range on Protein: 1351-1630
Range on HMM: 6-286/439.0
DLADNIERLKANDGLKFSQEYESIDP---GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMG
.. . .|.|. |.   |....|.|.      .        | ...|||| .| |.||.||.|  | ||| | |||||||.|| ... |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQRTATVVMMTRLEEKSRvkcdqYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQFMAWPDHGVPEYPTPILAFL
||||.|.|..|.|.||.| | |  .     |||. .    | | |     .||  |..| | . .    .  .| . ||...||||. ||   . .| ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||| | |. .| ||. |||.  |||||..|.||    | . |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1678-1914 3.3e-71 235.0 In-house 42-276 (515) alignment 
Range on Protein: 1678-1914
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||. .|| |. |     |||.|||.. ..  .|||||.|||.  |..||||.....| | |.|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||. ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   .||.|..|. .| .|| .|||..|| . | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1390-1621 4.4e-71 233.9 In-house 3-237 (237) alignment 
Range on Protein: 1390-1621
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVILTSIDGVpgSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARG-TETC
|| ||||.|..|||||||.|    .   ||||||.|..|.    . |||.||||  .  |||.|||... . .||.| | |. ..|| .|||     .. 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GLIQVTLLDTVELATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMK
| . |.|    |.. ||||.. | | ..  | | . |.|| .|||.|||.. . .| | ...   .|   ..|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .| |||| .| ..  .| |..||.|||||||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1658-1921 7.8e-71 233.4 In-house 26-285 (287) alignment 
Range on Protein: 1658-1921
Range on HMM: 26-285/287.0
FKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR
|..| . . .      .  . || |||| .|....  || |.     |  |||||.|.|||...||.|....|...   .||......| |.||||....
ftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSA
|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ....|.|.|.|...|  .. .  .  | .  ||. . | ...| ||||.
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsivvhCsd

GVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
.|||...|.   . ... . |||.|.|| .|  | |.| .||| .||.  . . |||| ||. |.
tvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1675-1915 3e-70 231.5 In-house 24-269 (274) alignment 
Range on Protein: 1675-1915
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-SDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .. ||.. .|||.||||||..  .|||||........|||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|..  . .||||.. .|.  . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
|| . ..| |.|||....|  || .|  ||||..||.| .||  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 1667-1907 3.4e-70 231.2 In-house 29-268 (280) alignment 
Range on Protein: 1667-1907
Range on HMM: 29-268/280.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpirGVEGsDYINASFLD----GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE
       |..| |  |||  .|.||. ||| |.     |  |||||....    .  . . |||||||||....|||.|.||..|..||||| | | || 
pglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRT
||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.| |.|...||..|||.  . |..|. .|.|...  |.. |. ||||||.|||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvvvhCsaGigrt

GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
||.|.| . |  .  .  | . . |.|.| || ..|||..||..  
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC
subfamily_PTPN1_pd Subfamily PTPN1 1377-1628 1.8e-69 228.7 In-house 19-276 (290) alignment 
Range on Protein: 1377-1628
Range on HMM: 19-276/290.0
GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
 ..|. ....|. |...||| .|  |||||..| . |     |||||. ..  . .  || ||||||.|.. ||.|||||.. .|||. .. ||...|| 
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPARGTETCG-----LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGR
||||    | .       ..|.|. . .  .||||.. |..  . | ||. .| ...||| |||| |.  | || .|. .  |  | || |.|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHT
.| |...|..| ......    |||  ..  .|..|  ..|| ||  | . |.|| | . ..
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1388-1630 9.3e-69 226.6 In-house 45-285 (287) alignment 
Range on Protein: 1388-1630
Range on HMM: 45-285/287.0
EVNKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETC
. ||.|||..... .|  ||.|         ||||| .||||....|.|....|. .|. .||.......  ..||.....|. . .| ||||   . . 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

GLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHG-VPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH
|  ...||.    | |..|.. ..... ...|....|.|. .|...| |.|. | .| . ...|.      ...|||||..|||.. |. ..  ... | 
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt

EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
| ..|..  .  .| |.  .||| .|| || ...||  ....| .
eGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1669-1914 1.6e-68 225.9 In-house 34-277 (315) alignment 
Range on Protein: 1669-1914
Range on HMM: 34-277/315.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW
.|  .|  . |  |||  ||.|.. .|| |. |     |||||||.. .. ..|||||.||||  | .|||||..... | |||.||..|  . || |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRTGVFIT
|     |...  . |. .      . . |.. ||  .  .|||. |||||.||..||.|    .. .| .|   ...  .. .. ||||||||||||.|.
PdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.  |..... . .||.|..||.||..|| .||||..| . | | ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1656-1915 3e-68 225.3 In-house 27-289 (325) alignment 
Range on Protein: 1656-1915
Range on HMM: 27-289/325.0
LEFKLLASSKAHTsrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
 ||.|| |  . .  .  | .| || |||. |..... .||.|.  .    |||||||.|  ..... ..|.| ||.....|.||.. . .....|.| .
hefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

LrEMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ----DGP
| . | ..| .||| |   | ..  . |  ..  ..  |. | ..| ....|..|...|||.  |.. ||.|    .| ..  |.. .|.        .|
l.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
| ||||||||||||||.|  .|...  |  ||.|. || || .||.||.| ||| |.| |  |.. 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1667-1918 3.9e-67 221.5 In-house 39-288 (297) alignment 
Range on Protein: 1667-1918
Range on HMM: 39-288/297.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQqkAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGReKCHQ
 .     |.   |  |.|  ||.||.  || |. .     |||.||||. |...   .|.|| |  .. .|||.|..... ..||||... |  . || .
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK--TGEGFIDFIGQVHKTKEQFGQDgPITVHCSAGVGRTGVF
||. . .. . . .|  ..  .   .| ||..||  .  . | ..|.||..||.. |..  . . ....| .|.|. .|  .  |. |||.||||||||.
yWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvl

ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
.|.  |. ... |  ||.|..|| || .|| .|||..||.. | | ||.| | |
ltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_PTPN13_pd Subfamily PTPN13 1657-1916 1.3e-66 219.7 In-house 16-271 (273) alignment 
Range on Protein: 1657-1916
Range on HMM: 16-271/273.0
EFKLLASSKAHTSRFiSANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSdYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLT
||| |   |.  .   ...   || |||  |..||. ||| |.     ||. |||||..      ..  |||.|||| |...|||.|.|| ....|.|.|
efkelrelkpldtce.vgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPIT
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| . ...|..||. |||.. . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|..|| || ..|||.||| ..|.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1679-1914 1.8e-66 218.9 In-house 20-264 (270) alignment 
Range on Protein: 1679-1914
Range on HMM: 20-264/270.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--R
.|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. ....||||.||...| |||.|.| | ||.|| .|||||.    .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

YQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKTGE------GFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL
...    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . .|. |||||||||||..|.|
ledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 |... .  .. ||. . .. || .|.|.||. .||.. |.| .|| 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1387-1638 3.3e-66 218.0 In-house 30-281 (283) alignment 
Range on Protein: 1387-1638
Range on HMM: 30-281/283.0
LEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYID---GYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARG
 . ||.|||. .....|  || | |       ||||| .|     |.... ||..|.|| .|. |||.||.... ...||.|.| |  |.|| |||| ||
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE-LRQFQFMAWPDHGvPEYPTPILAFLRRVKAC-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLE
.|  |   ||| . .   ..... . |....|...   |  .|.  | . | .. .   |  . .|..  .    ||.|||||.|.|||. || . | ..
sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
 .. |  ||..  |. || ||  .||| ||| ..||. || | || |.. | .|.. 
daltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1346-1667 1.7e-65 216.0 In-house 3-280 (392) alignment 
Range on Protein: 1346-1667
Range on HMM: 3-280/392.0
PIPITDLADNIERLKanDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|||....   .|. .      |..|.  .   . .    .. |.|..|||| |.. || .||.|  || .| |||.|| ||...  ..||||.||| . .
pipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MGDFWRMVWEQRTATVVMMTRLEEKSrvkcdqywpargtetcgliqvtlldtvelatytvrtfalhksGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
. ||||||......|..|.|.|.|                                               ..|   ||.|  |||..||.. . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV
. |||     . |...||||||||||  | ||... . |. . ||..  || .| .| |||||..|| ||. |.||      | .|   .  |.|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

PPGESVTAMELEFKLLASSKAH
  |.  . .  ||. | .|.. 
sdGdvrskqlkefrslkashtv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1677-1914 5.1e-65 214.5 In-house 47-279 (315) alignment 
Range on Protein: 1677-1914
Range on HMM: 47-279/315.0
PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAErSARY
  || ||| .||..|. .|| |  .   ..|||.||.|.||| ... |||.|||...| .||||...|.. . |||||.| |  ..|. .||| .    |
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviy

QYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |  . |    .|  | . |.   . . |.. |...| ||. ||||    ....| .|.. ...    |.| ||||||||||| ||||. ||...  
Gkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaea

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| ..|... .. .| .|  |||. .|||. | | || .
enaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPN23_pd Subfamily PTPN23 1650-1913 1.1e-64 213.0 In-house 13-279 (288) alignment 
Range on Protein: 1650-1913
Range on HMM: 13-279/288.0
SVTAMELEFKLLASSKAHTSRFISAN-LPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQ-KAYIATQGPLAESTEDFWRMLWEHNS
 .||.. .||.| ..... .|  |     ..  |||  .|.||. .||.|.     .  |||||||. .   .   .||||.||...  |||.|..|  |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHK--TKEQ
 .||||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ....  |.| ||| |||.. | ...|...|..  ...|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

FGQDGPITVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
   . |. |||||||||||||    ..| |  . .|..|. | |..||.||  |||...|.. .| | ||.
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1390-1622 1.4e-64 212.7 In-house 20-263 (270) alignment 
Range on Protein: 1390-1622
Range on HMM: 20-263/270.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQ-NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE---
.|  ||||...   ..||.| ...  . . ||||||. |. .. ..|||..|||| |. .||||.||... ..||.| |||| | ||..||||.  |   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-TCGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPT------PILAFLRRV-KACNPLDA-GPMVVHCSAGVGRTGCFIVI
 . | |.|. | ..    | ..   |...|.  .|.|  |.. .|||||||. .        .|. || | . .. ||  .|..|||||||||||..|..
ledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
| ... ....| ||.   .. .| .|  .||. .|| |...|..| 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPN14_pd Subfamily PTPN14 1657-1914 5.8e-64 211.0 In-house 28-296 (300) alignment 
Range on Protein: 1657-1914
Range on HMM: 28-296/300.0
EFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVeGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLT
|.  ..  ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| .      ... ||..||||    .|||.|.||.. ..|||||
eyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ----
. .| |.||...|.| .    ...... | |      . ...| . .|.     .. ||.  .|.||||..|||.  .||.... .|.  .... .    
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   . |. |||||||||||| |.  .... .  . ..|. .....||.||  .|||  ||.  |.. ..||
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPRN_pd Subfamily PTPRN 1380-1621 1.3e-63 209.5 In-house 46-290 (297) alignment 
Range on Protein: 1380-1621
Range on HMM: 46-290/297.0
FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYI-DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQY
 | | .. | |  |||...|..|||||| |..      ||||||  | |   .. |||||||||..|. |||.||||| .. .|..|||||..  .|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPARGTETCGLIQVTLLD-TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID
||  |.|. .. .| |.   .    | ||.| |    .|| | . || |..||..|||  . ..| | |.|  .    . |.|||||.|.||||..|.||
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

AMLERMK-HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .|.|..   | .||   .  .| ||. .|.|.||. |.  |. |
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_CG7180_pd Subfamily CG7180 1679-1914 1.8e-63 208.9 In-house 42-290 (296) alignment 
Range on Protein: 1679-1914
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||.. |.. ..|.|| |..|  |. ..|||.......  .|.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF---GQDGPITVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |....||.| |.  . ||   ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
... . || .. |. ||.|. ||||| .|| .|.. ..|. .|   ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1377-1620 3.7e-62 204.7 In-house 25-274 (287) alignment 
Range on Protein: 1377-1620
Range on HMM: 25-274/287.0
GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILtSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
.  .|. ...   .  |||||.|. .|..||.| | .|  |||||||||. .|....|.||.|||.. |..||||.|.|.|.|.|..|||  |..| || 
sstatfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPARGTE-TCGLIQVTLLDTVEL-ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV-----KACNPLDAGPMVVHCSAGVGR
.||| |      |   |.|||   .   |.||.. | .  . | | ..|.....|||....     .. |   |      | .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
.| .. . ....|..    ||.   |  .| .|. .||.  |. .. ||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_CG7180_pd Subfamily CG7180 1390-1627 8.1e-62 203.5 In-house 42-294 (296) alignment 
Range on Protein: 1390-1627
Range on HMM: 42-294/296.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTETCGL
|. |||. .|. ||. ||.|...||   |||||| |.|.. |...|| |..|  ||...|||.|... . .||..|.  . .. .. .||| .. |  | 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

IQVTLLDTVELATYTVRTFALHKS----------GSSEKRELRQFQFMAWPD-HGVPEYPTPILAFLRRVKACNP-L----DAGPMVVHCSAGVGRTGCF
| | .. . ..|  . ||| | |            . |.| ...||.  |.  . ||   . .. ..|||.          . ||.||..| |..|.| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

IVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGH
. ||| || ...|. ||... |  .| .|. .|.. ..| .| . ||||  |. 
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1677-1920 8.9e-61 200.2 In-house 38-299 (301) alignment 
Range on Protein: 1677-1920
Range on HMM: 38-299/301.0
PCNKFKNRLVNIMPYELTRVCLQPIRG--VEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA
  ||  ||  || .|.  |. |.| .   .   .|||||..|||...|..||.|||. .   ||||..|..  . |||.|.|.|  ..||.||||  .  
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

RY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAG
..    | |  . |...|....|...|.  |              .| .|... |.| ||||..|| .     .  | .| ... . |  ||. ||||..
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdt

VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
|.|.||....|| ||  . |||||.|| .|..| ..| .|.| .||   | .  .||   . |
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN23_pd Subfamily PTPN23 1388-1623 1.9e-60 199.2 In-house 41-280 (288) alignment 
Range on Protein: 1388-1623
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQ-NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET
...  |||. ... |||.|| |         ||||| .. .   .   .||||.||..|..|||.||.||.. ..||..  ||. . |.|.|||..  ||
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

--CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD----AGPMVVHCSAGVGRTGCFIVIDAM-
   | ..||| .. |. |.  |.. |.  .........  |...||..|||. |  .|.||  |...          |.|||||||||||| | .. |  
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
 |  |..  .||   |  .| || .|||...|. |  || ||||
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN14_pd Subfamily PTPN14 1368-1620 2e-60 199.4 In-house 26-293 (300) alignment 
Range on Protein: 1368-1620
Range on HMM: 26-293/300.0
SQEYESIDPGQQ-FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVpGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
 .||| | . ..  . . ..|..|..|||. .|. |...|| |..      ..||||  |      |.  ||..||||. |. |||.||||| .. .||.
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TRLEEKSRVKCDQYWPARG----TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACN-----PL-
|. ||. . |. .|.|  .    | . |  .||   . .  ... ... |.   |.|.|..  .|.. |||||||| ... | .|..|..          
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

---DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
      |..|||||||||||  |. | ... ..|....||   .. .| || ..|||  || |....|.
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPRN_pd Subfamily PTPRN 1654-1912 2.9e-60 198.5 In-house 31-290 (297) alignment 
Range on Protein: 1654-1912
Range on HMM: 31-290/297.0
MELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFL-DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM
.| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.. |   .. ||||||||||..  |||.|.||. ...||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPIT
||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||. || |  |||.||| .   ...|  .| |.    |.  || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCSAGVGRTGVFITLSIVLERMRyEG--VVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
||||.|.|||||.| . .||.|.   |   .|.  |.. || ||| .|.|.||..... |  |
vhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1678-1913 8.4e-60 197.0 In-house 32-265 (283) alignment 
Range on Protein: 1678-1913
Range on HMM: 32-265/283.0
CNKFKNRLVNIMPYELTRVCLQPIRGvegsDYINASFLD---GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA
 || |||  .|.|..  || |..       |||||.|.     |.|.| ||..|.|| .   |||.|..... | |||||||.|  |.|| |||| . | 
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSR-TIRQFQFTDWPEQGVPKTGEGFIDFiGQVhKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
 |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..|  .. 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasasvkd

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
.. | |||.|..|| .| ||. .||| |||.| . ..|| 
altesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1679-1914 1.5e-59 196.6 In-house 48-279 (439) alignment 
Range on Protein: 1679-1914
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| ...|| ..| |||||||  |.|.||||...|.... |||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||. ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|  ||.   || || ||  |||.  || . | | || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1660-1913 3.4e-59 195.0 In-house 19-276 (287) alignment 
Range on Protein: 1660-1913
Range on HMM: 19-276/287.0
LLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREM
|   |.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| .  ||||...|..|. ....|.  | 
lkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtrevee

GREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV--HK-TKEQFGQDGPITVHC
.| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| ..|... .||..... |  |.| |. .|  |   . .  . ||. ||.
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
..|.||.|..... ....|.   | ||. ..|  || .| |.||.  |..| | |   |
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
0051429 (Phosphotyrosine protein) phosphatases II 1415-1642 4.4e-58 192.3 In-house 1-243 (272) alignment 
Range on Protein: 1415-1642
Range on HMM: 1-243/272.0
VPGSDYINANYIDGYRK---QNAYIATQGPLPETMGDFWRMvWEQRTATVVMMTRLEEKSRVKCDQYWP------------ARGTETCGLIQVTLLDTVE
.| |.||||....|| .    .......|||| |  ||||. .|..  |.|.....||. |.|||.|||            .  | . | . |||| .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LATYTVRTFALHKS-GSSEKRELRQFQFMAWPDHGVPEYPtpILAFLRRVKAcnpldAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVD--------
|  |..|.. |..  . .| ||........|||||||. .  .|..|. . .      ||..||||||..|||...... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAaTCGHTEVPARNLYAHIQKL
... |  .|.|| ..||||.||.|..|||||.  .....|.|. | |... .
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1363-1625 3e-57 188.6 In-house 13-295 (301) alignment 
Range on Protein: 1363-1625
Range on HMM: 13-295/301.0
DGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG--VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT
   ||...|.... |.. . . .  | ||. ||. |.  ||. |.||.      .   .||||.|||||......||.|||. .|. ||||..|......
hsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

VVMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL---------------HKSGSSEKRELRQFQFMAWPDHGV-PEYPTPIL
.||.| |.|... || ||||     .|. | ..||| ..  .  ...| ...               ... . . ... |.|   ||..|| .|. | . 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

AFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
.    ... .  . ||.|||||..|.|.| .. ..  ||  | |  ||... .  .| ..  .|.| .||..|.... .  ..
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1679-1912 5.1e-57 187.8 In-house 3-237 (237) alignment 
Range on Protein: 1679-1912
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYELTRVCLQPIRGveGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||..|.|.    | |||.||||  | .|||.|.|. . ..||||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | | |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 . |||... |...  .|| ..||.||| . ... ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN1_pd Subfamily PTPN1 1666-1912 2.3e-56 185.6 In-house 19-269 (290) alignment 
Range on Protein: 1666-1912
Range on HMM: 19-269/290.0
AHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGvegsDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH
|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||.. .. ||.|.||..|  .||| |. | .. ||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGR
|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.| .| .| ||. |||..   |..|. .| ..     . ||  .|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.| |. .  .| ..  ..    ||. ...  || .|  ..|| || .. | | ||
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051429 (Phosphotyrosine protein) phosphatases II 1705-1916 2.7e-56 186.5 In-house 2-227 (272) alignment 
Range on Protein: 1705-1916
Range on HMM: 2-227/272.0
EGSDYINASFLDGYRQ---QKAYIATQGPLAESTEDFWRMlWEHNSTIIVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  . .||||. .|.. . ||.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPKTGegFIDFIGQVHKtkeqfgqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.......||||  |||.    ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
 ....|. || |||..||||.||. .|.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1678-1912 9.4e-56 183.6 In-house 6-238 (239) alignment 
Range on Protein: 1678-1912
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||.|  |    |||||||| .. |. |||||.|.    .||||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.  ||.|. ||..| .|| |||| .|| . . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1678-1912 1.2e-55 183.2 In-house 7-239 (239) alignment 
Range on Protein: 1678-1912
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||.|  |    |||||||| .. |. |||||.|.    .||||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.  ||.|. ||..| .|| |||| .|| . . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1673-1914 2.1e-55 182.7 In-house 39-236 (392) alignment 
Range on Protein: 1673-1914
Range on HMM: 39-236/392.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGrekchqywpaer
.|. . |. |||  ||.||. .|| |. |  .  |||.|||..... ..|||||.||| | | .|||||....| | |.|.|||.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

saryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhktKEQFGQDG-PITVHCSAGVGRTGVFITLSIVL
                              .  . ||. ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |.
..............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvv

ERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 . .   .||.|. |  .| .|| ||||..|| . | | || |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 1390-1630 3.7e-55 181.6 In-house 1-178 (182) alignment 
Range on Protein: 1390-1630
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRviltsidgvpGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTrleeksrvkCDQYWPargtetcgl
|..|||| ... |||||          ..||||||...|..... .|||||||..|. ||.||..|..  |.|..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iqvtlldtvelatytvrtfalhksgSSEKRELRQFQFMAWPDHGVPEyPTPILAFLRRVKAcnplDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhekTV
                         . ..|.  |.... |||||||. .  .|.|...|..    . || .|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
...  |  .||.|. ||.|..||.|.. ||||   .. |..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
0036282 (Phosphotyrosine protein) phosphatases II 1417-1617 2.4e-52 172.4 In-house 1-164 (174) alignment 
Range on Protein: 1417-1617
Range on HMM: 1-164/174.0
GSDYINANYIDGYRKQNAYIATQGPLPetmgdFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPArgtetcgliqvtlldtvelatytvrtfalhkSGSS
|||||||...|...  . .||.||||.     ||.|..|..  ||||.....|. ..|| .|||                                  ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKRELRQFQFMAWPDHGVPEYPTpILAFLRRVKACNPL-DAGPMVVHCSAGVGRTGCFIVIDAMLERMKhEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
..|.  |.... |||||||. .. .| |...|. .    . ||..|||||||||||...... || ... |..||.. .|  .|.|| .||||..|| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HE
..
yy
0036282 (Phosphotyrosine protein) phosphatases II 1706-1908 2.6e-52 172.3 In-house 1-164 (174) alignment 
Range on Protein: 1706-1908
Range on HMM: 1-164/174.0
GSDYINASFLDGYRQQKAYIATQGPLAestedFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||.||...  . .||.|||||     ||.||.|...|..|||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTIRQFQFTDWPEQGVPKTGEgFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERMRyEGVVDMFQTVKTLRTQRPAMVQTEDQYQL
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..|| ...|..||.||| ||||..||. 
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYR
.| 
lyy
0041856 (Phosphotyrosine protein) phosphatases II 1679-1914 5.4e-52 171.3 In-house 1-171 (182) alignment 
Range on Protein: 1679-1914
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYELTRvclqpirgveGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| ....||.|||.|.. |.||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTIRQFQFTDWPEQGVPKtGEGFIDFIGQVHKtkeqfgQDGPITVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 |.....||..| .|| ||.|..||.....|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1376-1622 3e-49 162.2 In-house 42-282 (290) alignment 
Range on Protein: 1376-1622
Range on HMM: 42-282/290.0
PGQQFtwENSNLEVNK--PKNRYANVIAYDHSRVILTsiDGVPGsDYINANYIDGYRkqNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRV
|.|..  | . .. |    |||| .|.  | .||||   || .| ||. |||..| .    .| |||.| .|. |.|||| ....|..||.  | |. . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPARGTETCGLIQVTLLD---TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRT
||.||.| .  |.  . ..|.|    . . |    .|... .  |  .  |. .. ..|||. |.     .|  || ..      .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
| |. |.. |. . . | .|. . |  .|  |   || . ||. . |.||. 
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0043147 (Phosphotyrosine protein) phosphatases II 1416-1617 1.6e-47 156.8 In-house 3-155 (172) alignment 
Range on Protein: 1416-1617
Range on HMM: 3-155/172.0
PGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLeeksrvkcdqywpargtetcgliqvtlldtvelatytvrtfalHKSGS
.|||||||.|.|.|.. . .|||||||..|. |||||..|.   ..|..|.|                                            . ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SEKRELRQFQFMAWPDHGVPeYPTPILAFLRRVKA-CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLermkheKTVDIYGHVTCMRSQRNYMVQTEDQYVF
 ..|.  |.... |||||||  .  .| ||. ..  ..  . ||..|||||||||||...... ||      . ....  |  .|..|...||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IHE
...
lyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1386-1623 5.2e-47 155.3 In-house 37-277 (307) alignment 
Range on Protein: 1386-1623
Range on HMM: 37-277/307.0
NLEVNKPKNRYANVIAYDHSRVILTsIDGVpGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE
 .. |  |||| .| . |..|.... .||.  |||| |||.    | . .|..|||| .|. .|| |. ...  .|.|. .. | ...||.||||.   .
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

T------CGLIQVTLLDTVELAT--YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFlrrVKACNpLDAGPMVVHCSAGVGRTGCFIVID
.         | |. | . .||     .   .|.   ... | ....|.  |||.|||.     . .   ..| .  |  |.||||||||||.|  . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGvGrsGtivais

AMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
 . ..| . .   |.   |  .||||.| .||| ||...|  |||  
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0049772 (Phosphotyrosine protein) phosphatases II 1662-1914 7.5e-47 155.9 In-house 29-280 (314) alignment 
Range on Protein: 1662-1914
Range on HMM: 29-280/314.0
ASSKAHTSRFISANLPCNKFKNRLVNIMPYElTRVCLqPIRGVEGSDYINASFLDGYrqqKAYIATQGPLAESTEDF----------WRML--WEHNSTI
  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .  .||          |||   ...|. .
slsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTIRQFQFTDWPEQGVPkTGE
|||                     |..| . |      ...|.. . ..                    .... ..  .|.. ..  ...|  ..| . |
ivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvpDgsap.lle

GFIDFIGQVHKTkeqfGQDGPITVHCSAGVGRTGVFITLSIVLERMryeGVvDMFQTVKTLRTQRP-----AMVQTEDQYQLCYRAALEYL
 | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. .... .| .||      .... .||. ...| ||||
dfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1384-1623 1.7e-46 153.4 In-house 27-259 (267) alignment 
Range on Protein: 1384-1623
Range on HMM: 27-259/267.0
NSNLEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvKCDQYWPARG
 |  | |. .||. ... ||..||||   .     .|||| |..||...||.|.||.||  |..||. .. .|. ...|..|.  .    .  ..|| . 
qsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkm

TETCGLIQVTLLDTVE--LATYTVRTFALHKSGSSEkRELRQFQFMAWPdhgVPEYPTPILAFLRRVKACNPLDAG--PMVVHCSAGVGRTGCFIVIDAM
 ..    ..|.  ..|     | . |. |.    |  ...  . .  |    .     | |  |  . | | |. |  |.||.||.||||.| |.|||..
gqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsq

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
|||.|.| ..||.  .  .||||  .|.| ..|..||| | | |
leraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
0046846 (Phosphotyrosine protein) phosphatases II 1412-1620 1.8e-46 153.4 In-house 6-170 (176) alignment 
Range on Protein: 1412-1620
Range on HMM: 6-170/176.0
IDGVPGSDYINANYIDGYRkqnaYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCgliqvtlldtvelatytvrtfalh
.   ...||||||.|.|.|    .||||||||.|. ||..|..|..  .||..| . |..|.||..|||   .. .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

ksgssekrelrQFQFMAWPDHGVPEYpTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDamleRMKHEKTVDIYGHVTCMRSQRN-YMVQTED
           |.... |||||||.. . .| .|. .. .   . || .||||||.||||......     ...|| ....  .  .|.||  ..|||..
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYVFIHEALL
|| |..|..|
Qyrflyefel
subfamily_ptpA1_pd Subfamily ptpA1 1385-1585 2.7e-46 153.2 In-house 42-258 (418) alignment 
Range on Protein: 1385-1585
Range on HMM: 42-258/418.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGY-RKQnaYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA--
 . . |  ||||.|..  .|.|| |  |.   ||||||||||||   ||  .|.||||||.|. ||||||||.|   .||..|  |. |.|||.|||   
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

---------RGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC----NPL--DAGPMVVHCSAG
          | |  |   | |.. ..     . |  .. .   | |.. |.|.  |||| .|..  |.  .|. .        |      |..||||||
ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGCFIVIDAMLERMKH
||||| |     |.... |
vgrtgtfctavimmkkldh
0043147 (Phosphotyrosine protein) phosphatases II 1705-1907 5.7e-46 151.7 In-house 3-154 (172) alignment 
Range on Protein: 1705-1907
Range on HMM: 3-154/172.0
EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||.||.|.  . .||||||| . ..||||||.|.. |.||.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTIRQFQFTDWPEQGVPkTGEGFIDFIGQVHKTKeQFGQDGPITVHCSAGVGRTGVFITLSIVLERMryegvvDMFQTVKTLRTQRPAMVQTEDQYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

LCY
..|
fly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1665-1912 2e-45 149.9 In-house 19-293 (297) alignment 
Range on Protein: 1665-1912
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpiRGVEGSDYINASFLDG--YRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE
.|..  | ||. .    |||  .|. .. ||| |.  |.. ..||||| ..      ..  || .|||| .. .|||....|..  .|||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKTGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| .|  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   .. || ||. .||| .|..|.| |.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0046846 (Phosphotyrosine protein) phosphatases II 1698-1915 2.1e-45 150.0 In-house 3-174 (176) alignment 
Range on Protein: 1698-1915
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFLDGYRqqkaYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||....|.|    .||||||| ....||..||.|.. |..|.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtirQFQFTDWPEQGVPKTgEGFIDFIGQVHKTKEQfgqDGPITVHCSAGVGRTGVFITLSivleRMRYEGVVDMFQTVKTLRTQRP-AM
              |.....||. |||   | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDQYQLCYRAALEYLG
|||..||. .|...|..|.
vqtpeQyrflyefellllk
0049772 (Phosphotyrosine protein) phosphatases II 1380-1624 2.4e-44 147.7 In-house 36-281 (314) alignment 
Range on Protein: 1380-1624
Range on HMM: 36-281/314.0
FTWENSNLEVNKPKNRYANVIAYDhSRVILtSIDGVPGSDYINANYIDGYrkqNAYIATQGPLPETMGDF----------WRMV--WEQRTATVVM----
.|.  ..|..|. |||| ... .| .|||| .  .| |||||||.|.||.   ...|||||||..|. ||          ||||  ..... ..||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTRLEEKSrvkcDQYWPARGTETCgliqvtlldtvelatytvrtfalHKS--GSSEKRELRQFQFMAWPDHGVPeYPTPILAF
                  ..| ..     .....|.  . .                            ..  .|.  ..  . .||...|  .  ...|
vladelsrLdaAlgKtpllildgng....neptaadlellk.......................eelydpelferlgikylripvpDgsap.lledfdef

LRRVKACnpLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHeKTVDIYGHVTCMRSqRN---YMVQTEDQYVFIHEALLEAAT
|. ....   . || .|||.||.||||.|.|.. .. ...     ... .|  .|.  |    .... .||.||.|||||.  
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylk
0049260 (Phosphotyrosine protein) phosphatases II 1425-1617 3.1e-44 145.6 In-house 1-144 (152) alignment 
Range on Protein: 1425-1617
Range on HMM: 1-144/152.0
YIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWpargtetcgliqvtlldtvelatytvrtfalhksgssekrelrQF
.||||......||||||.|.|. |||||..|.   |.||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLermkheKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
... |||||||. .  .| .|. .. ..  . || .|||||||||||...... ||      . |...  |  .|..|...|....|. |..|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1651-1914 2.1e-43 143.5 In-house 15-277 (307) alignment 
Range on Protein: 1651-1914
Range on HMM: 15-277/307.0
VTAMELEFKLLASSKAHTsrFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVeGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
|.|.  ||. ||  . ..       . .|  |||  ..   . .|. .. . |.  |||| | .|    . | .|..|||| ..  .|| |  ...   .
vqalvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHktke
.|| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..||||...|...||..|||..  . |...  |.    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

qfGQDGPITVHCSAGVGRTGVFITLSIVLERM-RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  ..  |. |||||||||.|  ...|.| ..| . .   || . |. ||.||.  .||| ||   .|  |||.
..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0049260 (Phosphotyrosine protein) phosphatases II 1714-1907 2.4e-42 139.5 In-house 1-143 (152) alignment 
Range on Protein: 1714-1907
Range on HMM: 1-143/152.0
FLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtirQF
|.|||......||||||. ....||||||.|.. |.|||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKTGEGFIDFIGQVHKTkeQFGQDGPITVHCSAGVGRTGVFITLSIVLermryeGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
... ||  |||.  . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|. .|..|| .|....|....|
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1653-1913 1.1e-41 137.6 In-house 7-258 (267) alignment 
Range on Protein: 1653-1913
Range on HMM: 7-258/267.0
AMELEFKLLASSKAHTSRfISANLP-CNKFKNRLVNIMPYELTRVCLQpirGVEgSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
 .| ||.|.      .|. ||  ..  |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  .  ||. .. ... ..||
eiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQY--ILREFKVtdaRDGQSRTIRQFQFTDWPEQGVPKTgeGFIDFIGQVHKTKEQFGqD
.|||    . .. ...|| .  .. .|| ..|.   | .  .|  |  |.|.   ..  .. .  . .  |  .   |    .  ..| . | . . | .
lltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.n

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
 |. |.||.||||.| |...   |||.. |||.|.|. .. .| ||...|.| ..|  ...   ||
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1369-1631 4.7e-41 135.3 In-house 31-297 (310) alignment 
Range on Protein: 1369-1631
Range on HMM: 31-297/310.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTsIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLE
..|  .|  |. .      . .  ||||..|.  | ||| |. ||     ||| |||.     ....| .||||  |. |||||....|. ..... .  
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvg

EKSRVKCDQYWPARG-TETCGLIQVTLL----DTVELATYTVrTFALHKSG----SSEKRELR--QFQFMAWPDHGVPEYPTPILafLRRVKACnpLDAG
|. | ||  |||. | ||| | |.|| |    .  |.   .| ||   .       .. .|||    ..  ||| |||.     .   .|. |   .  |
eegrpkcvgywpslgvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaq..vrhg

PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAtCGHTEVP
| |||||||..|... . ..  ...... . ||.   .| .. .|   .||| ||..|.   .  |  |.||| 
pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa.rgeteva
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1369-1621 7.6e-41 134.7 In-house 34-287 (305) alignment 
Range on Protein: 1369-1621
Range on HMM: 34-287/305.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILtsiDGVPGSDYINANYIDGY-RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRL
  |   |  |.    |   .... ||||..| . |.| | |   |  . |||| |||.      .. .|..|||| .|. .|| || ...   .||. . 
akytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlckt

EEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT-------YTVRTFALHKSGSsEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMV
 |  ..|| |||||   |   |    ... |  .          . .. |  ||. .|  .|..|.  ||| |||      | .|  ..  .     |.|
velgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgd.qkmsvrhlqwtewpdrgvppckltslellsairgsk....vpiv

VHCSAGVGRTGCFIVIDAMLERMKHEKTVD-IYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
||||||.||||  . |. .||..  .| .  .   | ..| || . .|.. ||.|||  .|.
vhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1384-1622 1.9e-40 133.3 In-house 31-268 (281) alignment 
Range on Protein: 1384-1622
Range on HMM: 31-268/281.0
NSNLEVNKPKNRYANVIAYDHSRVILTS-IDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPaR
  |  ||. ||||.|. . | ||| |   .     .||| ||||     .  || ||||  ||  |||||.|.. |...||. .. |  | || .|.| |
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp.r

GTETCGLIQvTLLDTVEL--ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRTGCFIVIDAML
 .  |  ..  |  . |      .. |  |  |   | | . .. .  |||  |||    .|  ||...|     . | |.||||||||.| .. ..  |
nahcclqfd.klsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveial

ERMKHEK-TVDIYGHVTCMRS-QRNYMVQTEDQYVFIHEALLEA
. ..      ||   |. .|   |   ||| .||..| . ||. 
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0051082 (Phosphotyrosine protein) phosphatases II 1706-1910 3.4e-39 129.2 In-house 2-149 (151) alignment 
Range on Protein: 1706-1910
Range on HMM: 2-149/151.0
GSDYINASFLDGYrqqkaYIATQGPlaesTEDFWRMLWEHNSTIIVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . ||.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKtkeqfGQDGPITVHCSAGVGRTGVFITLSIVLERmryegvVDMFQTVKTLRTQRPAMVQTEDQYQL
  .........|||..|.| . . ...|. .. .      ..||. ||||||.||||... | ..|..      |....... .| .|| .||...|...
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYRAA
...| 
qlfal
subfamily_ptpA1_pd Subfamily ptpA1 1654-1874 6.1e-39 128.9 In-house 23-256 (418) alignment 
Range on Protein: 1654-1874
Range on HMM: 23-256/418.0
MELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRqQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.. ||.||  |    |     .   |  |||  ||.| . ||| |. |.  |||||||| ..||    | .|.||||| ..  |||||.||    |||||
ikeefrlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivml

TKLREMGREKCHQYWPAERSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTK
..  |  | || .||| .     |. .       .  |     .. |   ||        . .|..| | |.|.  ||.. .|   . | ...  . . .
sresencrikcdrywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

EQF----GQDGPITVHCSAGVGRTGVFITLSIVLERM
.|      .. || ||||||||||| | |  |.....
nqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
0044763 (Phosphotyrosine protein) phosphatases II 1690-1913 1.9e-38 127.2 In-house 1-170 (178) alignment 
Range on Protein: 1690-1913
Range on HMM: 1-170/178.0
PYELTRVCLQPIRGVEGSDYINASFLDGYrqqkAYIATQGPlaestEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||. ...     |.....|     .|....|.|.. | ||.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtiRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSIVLERmryeGVvDMFQTVKTL
                      |.... .|  |||   | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... .. .
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDQYQLCYRAALEY
| .|| .|....|.. .|. .|..
rerRp.ivpnpgqlrqLyefelrl
0044763 (Phosphotyrosine protein) phosphatases II 1402-1619 2.6e-38 126.8 In-house 2-167 (178) alignment 
Range on Protein: 1402-1619
Range on HMM: 2-167/178.0
YDHSRVILTSIDGVPGSDYINANYIDGYrkqnAYIATQGPlpetmGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTetcgliqvtlldtvela
.|..||.|... |...||||||..|...     |.....|      |......|.   ..|..|   |  ..|||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tytvrtfalhksgssekrelRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhekTVDIYGHVTCMRSQ
                     |.... .||||||. .  .|.|.. .... . . || .|||||||||.|...... |...      ....  .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYVFIHEAL
|. .|....|. ...|  
Rp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 1417-1620 3.8e-38 125.8 In-house 2-150 (151) alignment 
Range on Protein: 1417-1620
Range on HMM: 2-150/151.0
GSDYINANYIDGYrkqnaYIATQGPLPetmgDFWRMVWEQRTATVVMMTRLEEKSrvKCDQYWPARGtetcgliqvtlldtvelatytvrtfalhksgss
 |||||..|..|.     .....|||.    ||.....|.   |.|... .||    .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAcnpLDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhektVDIYGHVTCMRSQRNYMVQTEDQYVFIH
  .|....... |||.|.|...  .|.||. . .    . ||..||||||.||||...... ||..      |...  .  .|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EALL
 |||
fall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1387-1622 4.7e-38 125.8 In-house 32-269 (285) alignment 
Range on Protein: 1387-1622
Range on HMM: 32-269/285.0
LEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGY-RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE
 | |   ||||.| . . .||.|   |     ||| |...    . |..||.||||||||. |||.|..... | |.|.  | |    ||  |.| .  |
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

T--CGLIQVTLLDTVELATY----TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAgPMVVHCSAGVGRTGCFIVIDAM
    |  ..|| .  | |         |    .  |||   . . |   |||.  ||   |.. . . ||  || .  |..||||||||||  |. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidya

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
  |.  .  ...   |  ||. |   ||.  |..|..  |.| 
tirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1673-1913 1e-37 124.3 In-house 31-268 (281) alignment 
Range on Protein: 1673-1913
Range on HMM: 31-268/281.0
SANLPCNKFKNRLVNIMPYELTRVCLQP-IRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE
  | | |. ||| .||   ...|| |.  .   . .||| | ..     .. || ||||  |.  |||||.|. |.| |||| .. |  |||| .|.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKtkeqfgQDGPITVHCSAGVGRTGVFITLSIVL
  .  |.  .    |    .  |   ..  . .|..| | .. . .||.  ||.. | ..  . ...       .  |  .||||||||.| .... | |
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveial

ERMRYE-GVVDMFQTVKTLR-TQRPAMVQTEDQYQLCYRAALEY
. ..    . |. | |  || | | | ||| .|| | ..  |..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1390-1621 1.6e-37 123.9 In-house 48-285 (305) alignment 
Range on Protein: 1390-1621
Range on HMM: 48-285/305.0
NKPKNRYANVIAYDHSRVILtsiDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCG-
.. |||| .|   |. || |   .|    .|| |||.    . . .| || || .|  ||| | ....  .. |.  | ||   || .|....  ..   
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

-----LIQVTLLDTVEL-----ATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRTGCFIVID
      |.| .  .|.|     |  .|.   |   |. ...|   .. .. ||| |||   . || .| . ..      ||.|||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvmle

AMLERMKHEKTVDIYGH-VTCMRSQRNYMVQTEDQYVFIHEALLE
 .|...   . ..   . .  .| |||  .||..||.|.|. .|.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
PTPc_DSPc_SM00012 1809-1912 8.7e-37 120.9 In-house 1-105 (105) alignment 
Range on Protein: 1809-1912
Range on HMM: 1-105/105.0
TIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
|......|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . ||.||.|| ||.||| |||||.||. .|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAALE
|| ||
ralle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1681-1916 6.7e-36 118.4 In-house 58-285 (290) alignment 
Range on Protein: 1681-1916
Range on HMM: 58-285/290.0
FKNRLVNIMPYELTRVCLQpiRGVEGsDYINASFLDGYRqqKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|.... |.|||. ... . |||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTkeqfgqDGPITVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |...   ..  .  . |.       ||..||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
  .|. ..|..||  | . || . || .  .. |..  .
keldlldlvralrnsrlnsvqvdiqylalveilldlGkd
PTPc_DSPc_SM00012 1521-1621 6.8e-36 118.0 In-house 2-105 (105) alignment 
Range on Protein: 1521-1621
Range on HMM: 2-105/105.0
LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA--GPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
........||||||||....|| .|| || ..   .  .|.||||||||||||.|...| .|.....| |.|||.  |  .|.||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1390-1551 2.3e-34 113.6 In-house 33-196 (297) alignment 
Range on Protein: 1390-1551
Range on HMM: 33-196/297.0
NKPKNRYANVIAYDHSRVILTsiDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTE
   |||| ...|.| .|| |    .....|||||.|.      ..  || .|||| .|. |||..|.||   ..||...|.|  | ||  |||    .  
slrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

TCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC
..| . |  | ..     .|    |.    ||.| .|  ||..|||||||     .  |  .| .|
kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_CG42327_pd Subfamily CG42327 1390-1550 5.8e-34 112.2 In-house 28-192 (319) alignment 
Range on Protein: 1390-1550
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR----GT
 |.|.|..||.   ..||.| .|   . . |..|.|. ||.. .| |||.| .| ..  ||||.||||.. ..| .| | |.   .| .|.|..    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFmAWPDHGVPEYPTPILAFLRRVKA
.. | |.||| .      | . |. |..   .| |||  . .  |.. .||  .....| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1679-1914 1.7e-33 110.5 In-house 55-289 (305) alignment 
Range on Protein: 1679-1914
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYELTRVCLQPIRgveGSDYINASFLDGY-RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   ... | |.       |||| | ..      .| .|..|||| .. ..|| |. ...   |||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHktkeqfGQDGPITVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. ..|..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||..  .  .  | . ||.|| ||   .|.. ||   .|  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1390-1637 8.8e-33 108.6 In-house 43-284 (288) alignment 
Range on Protein: 1390-1637
Range on HMM: 43-284/288.0
NKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGL
|  ..|| |.   | .|| |.         ||.|| .   . ..  | .| ||  |.. .|.|. |.    .||...| || . | ..|.| .  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

IQV---TLLDTVELAtYTVRTFALHKSGSSEKRE-LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMVVHCSAGVGRTGCFIVIDAMLERMKH
 ..   .  . ...   .|.   |. |   |..  ...  .  |.|.||||   . | .| ..|...     |.|||.|||||||| .|.|  .|| .. 
grlctvvkkkradid.klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCgHTEVPARNLYA
.  . |   .. .| .|   .||| ||...|  .||     .  .. |....
ddflgirsllaklreerfkaiqtemqylyvhrcvleelll.kkykvlredfv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1710-1903 2.3e-32 106.9 In-house 78-270 (301) alignment 
Range on Protein: 1710-1903
Range on HMM: 78-270/301.0
INASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | ...   . . .||||||| ...|||| ||  ..   ||||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgqdgPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY
 ..||.  .|...|...||||.     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||. | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1384-1614 5.5e-31 102.4 In-house 44-272 (301) alignment 
Range on Protein: 1384-1614
Range on HMM: 44-272/301.0
NSNLEVNKPKNRYANVIAYDHSRViLTSIDGV--PgsdyINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA
.|.  ..| |.|| .|    .. |     ||   |    | ||.|.   . . .|||||||..|. ||| |.      ..||...  ||   ||..| | 
esyaylpkdkhryptvPckPstav.evivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

RGTETCGL--IQVTLLDTVELA--TYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMVVHCSAGVGRTGCFIVI
. .|.  .   .... ..  .     . ||. ..  .|  . | .  .|.. |.|.|||.  . .  ..  ||  .     |.|||||||.||. .||  
kisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigt

DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF
. .  ... ..|...   .  .| .|   |||. |  .
eylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1679-1914 4.4e-30 99.6 In-house 35-270 (285) alignment 
Range on Protein: 1679-1914
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYELTRVCLQPirgvEGSDYINASFLD-GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| |.  |||.|... . . ..||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  |.  .  ..|.. |. .|. |   ||.  |. . |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1669-1914 2.6e-29 97.2 In-house 33-271 (288) alignment 
Range on Protein: 1669-1914
Range on HMM: 33-271/288.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW
|  |  .   |  ..|  |.   ..||| |.     .   ||.|  .   . ..  | .| ||    | .|.|| | .   ||||..| | |.||  .|.
sidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf

PAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKTGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRTGVFI
| .   .||.. .  .   ...  . ...   .   . |. .  ...  . .|...|||.    .. ..  .         . || ||.|||||||| .|
PsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtli

TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   |.|| .| .  . . . .. || .|   .||| ||   .|  ||.|
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1680-1914 8.3e-29 95.3 In-house 49-287 (305) alignment 
Range on Protein: 1680-1914
Range on HMM: 49-287/305.0
KFKNRLVNIMPYELTRVCLQPirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYF
. |||  ..   .  || |..       .|| | ..    . | .| || || ..  ||| | ....   | || .| | | .||..|....     .. 
agknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

------VVDPMAEYNMP------QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRTGVFITL
      .|   .  ..         . .   | .   ...| . .. . |||..||| .    .... .   .|      |||.||||||.||||  . |
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvml

SIVLERMRYEGVVDM-FQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  .|...    ...   . .. .| ||   .||..|| . ..  |.|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1517-1642 3e-28 93.3 In-house 87-213 (440) alignment 
Range on Protein: 1517-1642
Range on HMM: 87-213/440.0
EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
| | |.|... .|||.|||..  |.| ... |. . .    ||..||||||.||||  |..|..|   |.   .||.  . .||..|  |||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEALLEAATCGHTEVPARNLYAHIQKL
|||.||.  || | .   ..  .....
heavlegllcgdtliledditerveqi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1391-1622 4e-28 93.0 In-house 44-275 (312) alignment 
Range on Protein: 1391-1622
Range on HMM: 44-275/312.0
KPKNRYANVIAYDHSRVILTSIDGVpgsdYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--------
|  ||| |.  .|  |  |.  .      || ||..    | . ...||||| .|   ||...    ........ . | .  || .|            
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

---GTETCGLIQVTLLDtVELATYTVRTFALHKSGSSEKreLRQFQFMAWPDHGVPEYPTPILAFLRRVKAcnplDAGPMVVHCSAGVGRTGCFIVIDAM
    || |  |..      .  |. |    .. .|   |  | ..|. .|||||.|.     | .|  ||     |  |.. |||||||||| ...|..|
hrvyteycteieiggks.kdkithrvlkvvvkatgqesk..lnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesm

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.  ..| .  ..      .| .|   |..  |||.   ..|| 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_egg_pd Subfamily egg 1384-1619 4.1e-28 92.9 In-house 34-266 (307) alignment 
Range on Protein: 1384-1619
Range on HMM: 34-266/307.0
NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrVKCDQYWPARG
..  . |. | |   |   | ||| |    |    |.| ||...|    | .| .| || .|. ||||||....   .||.|   |    .|. |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

TETC----GLIQVTLLDTVELATYTVRTFALHKS-GSSEKRELRQFQFmAWPDHGVPEYPTPILAFLRRVkacnpldAGPMVVHCSAGVGRTGCFIVIDA
...     | .... |.  . |    |   |.   |  |.| |  .|   .   .   .|  .|  ||..       . |.||..  || ...... |. 
sdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.......skpvvvqdilGvskaatlvaiei

MLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL
 |  .    .    .   |  .| .|.. |..  .|.|..  .
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_CG42327_pd Subfamily CG42327 1677-1841 1.6e-27 91.1 In-house 26-194 (319) alignment 
Range on Protein: 1677-1841
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQK-AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| .|. ||||..|| .| .|| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFtDWPEQGVPKTGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .||   . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
0048076 (Phosphotyrosine protein) phosphatases II 1493-1620 3.3e-27 90.3 In-house 18-140 (145) alignment 
Range on Protein: 1493-1620
Range on HMM: 18-140/145.0
TLLDTVELATYTVRT-FALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDAMLErmkhEKtVDI
| ||  .|. . ..| . |    . ..|.  |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.    .. |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsl

YGHVTCMRSQRNYMVQTEDQYVFIHEALL
.  .  .|||| ..|....|. |..|..|
eealelvrsqrpgavpnpgqlrflyefel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1719-1908 3.5e-27 89.9 In-house 2-198 (199) alignment 
Range on Protein: 1719-1908
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTIRQFQ
. |. ||||| || |.  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKTG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM--RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYR
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.. |.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1720-1908 4.5e-27 89.5 In-house 2-197 (198) alignment 
Range on Protein: 1720-1908
Range on HMM: 2-197/198.0
QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTIRQFQF
 |. ||||| || |.  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKTG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM--RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYR
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.. |.
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 1500-1617 1.9e-26 87.9 In-house 28-139 (144) alignment 
Range on Protein: 1500-1617
Range on HMM: 28-139/144.0
LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDAMLermkHEKtVDIYGHVTCMR
|  .|| ... .    ...||  |.... |||||||.... .|.||. .... . . ||..|||||||||||...... |.    ... ....  .  .|
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvr

SQRNYMVQTEDQYVFIHE
|.| ..|....|. |..|
srrpgavpnpgqlrfLle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1679-1911 6.6e-25 82.3 In-house 52-287 (310) alignment 
Range on Protein: 1679-1911
Range on HMM: 52-287/310.0
NKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQ
.  |||  ...  . .|| |. |      ||| | ..     ....| .||||  .  |||||...  .  |..| |  | || ||  |||.   .  | 
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

YFVVDPMAEYNMpQYILREFKVTDA-----RDGQSRTIR-----QFQFTDWPEQGVPKTGegfIDFIGQVHKTkeQfGQDGPITVHCSAGVGRTGVFITL
   |  ..|    .. . .. ||        | |   ..       .. .||..|||         . |   .  |  . ||  ||||||..|..| ..|
cirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvval

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
 . .....    ||. . .  |. .|   .||| || .  |  .
klkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1392-1485 1.5e-24 81.4 In-house 49-156 (350) alignment 
Range on Protein: 1392-1485
Range on HMM: 49-156/350.0
PKNRYANVIAYDHSRVILT----SID----GVPGSDYINANYIDGY---RKQN---AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
 |||| |.. |.||||.|     | |     . ..|||||||.       ..|    |||||.|||.|. ||.... .     ....| . |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPARGTE
||.  . .
YWqegsyd
0048076 (Phosphotyrosine protein) phosphatases II 1794-1913 2.4e-24 81.0 In-house 36-142 (145) alignment 
Range on Protein: 1794-1913
Range on HMM: 36-142/145.0
LrefkvTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgqDGPITVHCSAGVGRTGVFItlsiVLERMRYEGvVDMFQTVKTLRTQR
|     |. ... .|.. |.....||  |||   | ...|. ....  ..   .||. |||||||||||...    ..  |...| |....... .|.||
l.....tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqr

PAMVQTEDQYQLCYRAALEY
| .|....|.. .|.. ||.
pgavpnpgqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1681-1770 1e-22 75.3 In-house 49-152 (350) alignment 
Range on Protein: 1681-1770
Range on HMM: 49-152/350.0
FKNRLVNIMPYELTRVCLQ----P----IRGVEGSDYINASFLDGY----RQQKA--YIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ
 ||| .||.||| .|| |.    .       ....|||||..|       ...    |||||.|| .  .||.... . . ..|..||.. |...|||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPA
||. 
YWqe
subfamily_egg_pd Subfamily egg 1651-1911 1.2e-22 75.0 In-house 13-267 (307) alignment 
Range on Protein: 1651-1911
Range on HMM: 13-267/307.0
VTAMELEFKLLASSKAHTSRFISANlPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
|  .|  ...|  |  . |   .|.   |. | |   .   . .|| |.  ||    |.| |  ..|      .| .| || .. .|||||... .   |
vqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtiRQFQFTDWPEQGVPKTGEGFIDFigQVHKTKEQFg
||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .... .  .  .| .   .  
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnl.

qDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVV--DMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
   |. |..  || ........ | |  .    ..   . ..|. || .|.  |..  .| . ||  |
.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1806-1915 1.7e-22 74.4 In-house 87-195 (440) alignment 
Range on Protein: 1806-1915
Range on HMM: 87-195/440.0
QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQL
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|.|  ....| .|| |||| .|| .
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYRAALEYLG
 . | || | 
vheavlegll
0048179 (Phosphotyrosine protein) phosphatases II 1796-1908 2e-22 74.9 In-house 48-139 (144) alignment 
Range on Protein: 1796-1908
Range on HMM: 48-139/144.0
EfkvtdardgqsrtIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRTGVFITLSivleRMRYEGvVDMFQTVKTLRTQRPA
|             . |.....||  |||   | ...|.  ...  |   ..||. |||||||||||.....     .|...| ........ .|..|| 
e.............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpg

MVQTEDQYQLCYR
.|....|.. ...
avpnpgqlrfLle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1431-1616 2.7e-22 74.1 In-house 33-214 (255) alignment 
Range on Protein: 1431-1616
Range on HMM: 33-214/255.0
KQNAYIAtqgplpeTMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS--SEKRELRQFQFMA
..| |.        |.  |....  ..| .|||.. ..|....||..|.|    |   | .|..  |   |   .||  .    .   . .... ...  
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPEYPTPILAFLRRVKacnplDAGPMVVHCSAGVGRTGCFIVIDAMLE----RMKHEKTVDI--YGHVTCMRSQRNYMVQTEDQYVFIH
|...  || .  ||  |. |.     |. ..|||||.|.||.  |.... .       ..  .||..     .. .||.|.  ..|  |  |  
WieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1431-1616 5.9e-22 72.8 In-house 3-197 (199) alignment 
Range on Protein: 1431-1616
Range on HMM: 3-197/199.0
KQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQF
 |  ||||| || ||| |||.||||  .  .||.   . .  .    |||.   ||   | . ||    .  . ||. .. | ..       ||. ..||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MAWPDHGVPEYPT---PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIH
 .| ..  |.       ..|     |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1432-1616 1.3e-21 71.7 In-house 3-196 (198) alignment 
Range on Protein: 1432-1616
Range on HMM: 3-196/198.0
QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQFM
|  ||||| || ||. |||.||||  .  .||.   . .  .    |||.   ||   | . ||    .  . ||. .. | ..       ||. ..|| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPEYPT---PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIH
.| ..  |.       ..|     |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1559-1626 2.1e-21 70.1 In-house 1-68 (69) alignment 
Range on Protein: 1559-1626
Range on HMM: 1-68/69.0
MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
||||||.| |||| || |   . |.| || |||.  |  ||  |  ||  | .|.|||.|| ||   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1682-1920 2.1e-21 70.9 In-house 46-282 (312) alignment 
Range on Protein: 1682-1920
Range on HMM: 46-282/312.0
KNRLVNIMPYELTRVCLQpirGVEgSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| ...  ||..     || |..|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgqdgPITVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| . .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
.|.    .. ..   || .|   |..  ||  . |. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1560-1626 2.2e-20 66.8 In-house 1-67 (69) alignment 
Range on Protein: 1560-1626
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
|||||.| |||| || |   . |.| || |||.  |  ||  |  ||  |..|.|||.|| ||   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1389-1621 4.3e-19 63.2 In-house 46-277 (303) alignment 
Range on Protein: 1389-1621
Range on HMM: 46-277/303.0
VNKPKNRYANVIAYDHSRVILTSidgvpgSDYINANYIDGYRKQNAyIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE---
 |  |||...||  |||.| |.       | || |.|..   ...| | || ||. |  |||.|. ||.   |...    |  ..  |  .|        
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

TCGLIQVTLLDTVELATYTVRTfALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPI-LAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFIVIDAM-LE
    |.|  .  |||.   |    |  |  . |  |   .. |||   .|   .|  .  . ....   .  |. | |    .|.||.| | ....  | 
eersirvgefkrvelgdgwvlk.vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
  . . ..|.   .  .|  | . ||   |. ...  | |
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1438-1615 5.7e-19 62.7 In-house 96-280 (302) alignment 
Range on Protein: 1438-1615
Range on HMM: 96-280/302.0
TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL--LDT-VELATYT------VRTFAL--HKSGSSEKRELRQFQF
   |  .|.  .| .. . ..| || .. . |.   || .|.  .  ..  . . |.  ..   .|. .|      . |  .  .|  .  |. .  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

MAWPDHGVPEYPTPILAFLrrvKACNPLDAGpMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
 |||||| |. . . |  |   | |.      ..||||||||||| .. |   ..  ...|. |.   |. .|. |   ||.|.| ...
sawpdhGapkeaytaldil...kfcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
I-set Immunoglobulin I-set domain 33-124 6.4e-19 59.5 Pfam-A 1-90 (90) alignment 
Range on Protein: 33-124
Range on HMM: 1-90/90.0
PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDgAGSVLRIQPLRVqRDEAIYECTATNSLGEINTSAKLSV
|.| . ..|..   |  ... |...|||.|...|.|.|....|..   ..... | . |.|.  .| .|| .|.|.||||.|. ...|.|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnvev.sDeGkYtckatnsagkaeakaeLkV
subfamily_hpo-7_pd Subfamily hpo-7 1431-1616 5e-18 60.0 In-house 36-220 (263) alignment 
Range on Protein: 1431-1616
Range on HMM: 36-220/263.0
KQNAYIAtqgpLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS--SEKRELRQFQFMA
..| |.     | .|.  |....  ..| .|||..  .|....||..|.|    |   | .|..  |       ..|  | .  .   . ........  
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPDHGVPEYPTPILAFLRRVKACNpldagPMVVHCSAGVGRTGCFIVIDAM----LERMKHEKTVDI--YGHVTCMRSQRNYMVQTEDQYVFIH
|...  || .  ||  |. ..        ..|||||.|.||.  | |.. .    .  ..  .||..     .. .||.|.  ..|  |  |  
Wiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
fn3 Fibronectin type III domain 325-405 1.3e-17 56.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 325-405
Range on HMM: 2-85/85.0
PPIDLVVTETTATSVTLTWDSG--NSEPVTYYGIQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPS
.| .| |.|.|.||.||.|.    ...|.|.| ..|| .|.... .|..  .|| .. . || | .|| ||| |||  | ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1682-1913 1.6e-17 57.9 In-house 54-284 (302) alignment 
Range on Protein: 1682-1913
Range on HMM: 54-284/302.0
KNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAEST---EDFWRMLWEHNSTIIVMLTKLREMGReKCHQYWP--AERSARY
||.  ..  .. ..| |.     |  .|.||| ..    ..  | .| |  .|.   |.|||| .... . .|.| .  |. .   ....|  ..    |
knqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

QYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
. . |     |.   .    .. .    .| | ..      .| |... ||.     |  . .|   ...   | .. .    |.|| |.|.|| ...|.
gkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavavek

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
.  .  . . ..||..|.|||..|.. .||   |.|.| |
lqkgkepnikeivksiRsqRpravdslkQyvslyiallly
fn3 Fibronectin type III domain 923-1004 2.4e-17 56.0 Pfam-A 3-85 (85) alignment 
Range on Protein: 923-1004
Range on HMM: 3-85/85.0
PQNLHVTGLTTSTTELAWDPPVlaERNGRIISYTVVFRDINSQQ-ELQN-ITTDT-RFTLTGLKPDTTYDIKVRAWTSKGSGPLS
|.||.|.. |... .| |.||   ...| | .|.| .|. .... . .  .. .| ..|||||||.|.| ..|.| . .| || |
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 613-700 4.4e-17 55.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 613-700
Range on HMM: 2-85/85.0
PPQKVMCVSMGSTTVRVSWVPPPadSRNGVITQYSVAYEAVDGEDrgRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES
.|. . . ...||....|| ||.  ...| || |.| |. ..|..   ..   ..| ..|  | ||.  |||...|.|....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1716-1903 5.9e-17 56.1 In-house 84-277 (302) alignment 
Range on Protein: 1716-1903
Range on HMM: 84-277/302.0
DGYRQQKAYI-ATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  ...| .| .. ..| .|.| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIgqvhKTKEQFGQDgpITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY
. . .|.  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|.| 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1734-1900 9.3e-17 55.9 In-house 40-207 (255) alignment 
Range on Protein: 1734-1900
Range on HMM: 40-207/255.0
STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTIRQFQFTDWPEQGVPKTGEGFI
. . |....   ... .|||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .|.. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPITVHCSAGVGRTGVFITLSIVLERMR------YEGVVDMFQTVKTLRTQRPAMVQTE
  .  |...|       .. ||||.|.||.  |.   .|  .|         . .|  . .. || .|.. ..| 
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1387-1620 1.3e-16 55.0 In-house 48-282 (302) alignment 
Range on Protein: 1387-1620
Range on HMM: 48-282/302.0
LEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGYRKQNAYIATQGPLPETM---GDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWP--A
   |  ||.  .| ..|. .|.|.        .|.||  ..    ..  | .| |  ..     .|||||.... ..||.. . || ..   ....|  .
fkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

RGTETCGLIQVTLLDtVELATYTVRTFAL--HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAM
   .. | . |     || |  ..  ...     | |.        .  |... ||.  . . .    | | .     ..|.    |.|| | |..  . 
gdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
.|.....| . |   |. .||||  .|.. .|||... |||
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall
fn3 Fibronectin type III domain 518-596 2.6e-16 52.7 Pfam-A 2-83 (85) alignment 
Range on Protein: 518-596
Range on HMM: 2-83/85.0
QPADFQAEVESDTRIQLSWLLPP--QERIIMYELVYWAAEDED-QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGV
.| .....  ..| ..|||  |.  .. |  ||. |. .....  ... .  .|.|.||..|||.| |.|...|... | | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1346-1440 3.4e-16 53.2 In-house 4-95 (95) alignment 
Range on Protein: 1346-1440
Range on HMM: 4-95/95.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDgvpGSDYINANYIDGYRKQNAYIATQG
|| .. .   .  ...|   .| .|. ||      ..     | | ||||. |.. || .||.||.      |||||| ..||| ..|.|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1388-1618 5.4e-16 53.6 In-house 17-254 (290) alignment 
Range on Protein: 1388-1618
Range on HMM: 17-254/290.0
EVNKPKNRYANVIAyDHSRVILTSIDGVPGSDYINANYIDgYRKQNAYIATQGPLPET-------MGDFWRMVWEQRTATVVMMTRLEEKSRV----KCD
. .. ..|... ..  ..||.|        .||| ||..  . .  . |.|| |. ..       . .|| |. . .   |||.   ||||.      | 
kkhemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

QYWPARGTET--CGLIQVTLLDTVELATYTVRTFALhKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKaCNpldAGPMVVHCSAGVGRTGCFI
.| | .  |    . ..|   . ..     .|.  . | .  |.  .   ..  | .  |.| .  .|. .. || ..     |..|||  |. |  .. 
kYvpesvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAala

VIDAMLERMK-HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA
 |.     .   .. | .   .  .|.||. ..... .. |.  .
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag
fn3 Fibronectin type III domain 715-813 8e-16 51.1 Pfam-A 2-85 (85) alignment 
Range on Protein: 715-813
Range on HMM: 2-85/85.0
PPRKVEVEPLNSTAVHVYWKLPVpsKQHGQIRGYQVTYVRLENGEprglpiiqdvmlaEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARS
.|. . |.. .|| ... |. |   ...|.| ||.|.|   ..||             | ...  ..  .. |..||.| |.|...|.|....| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_CG42327_pd Subfamily CG42327 1846-1913 8.1e-16 52.6 In-house 246-314 (319) alignment 
Range on Protein: 1846-1913
Range on HMM: 246-314/319.0
QDGPITVHCSAGVGRTGVFITLSIVLERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
. ||..|||| ||||||. |.  | ....      ||. |.|  .| .|   |.| .||.. |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_CG42327_pd Subfamily CG42327 1555-1621 9.3e-16 52.4 In-house 246-313 (319) alignment 
Range on Protein: 1555-1621
Range on HMM: 246-313/319.0
DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
. ||.||||| ||||||  |  |  ......  ..|||   |  .| .|   |.| .|| ||.  | |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1392-1480 2e-15 50.9 In-house 50-154 (349) alignment 
Range on Protein: 1392-1480
Range on HMM: 50-154/349.0
PKNRYANVIAYDHSRVILT--------------SIDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKC
 |||| ... |.||||.|                 |.    |||||||.       .. ||||| ||| |. ||....  ..   |. ..  .|.|  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWP
|.|| 
diywq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1516-1620 3.5e-15 50.6 In-house 212-341 (350) alignment 
Range on Protein: 1516-1620
Range on HMM: 212-341/350.0
SEKRELRQFQFMAWPDHGVPEYPTPILAFLR-------RVKACNPL---DAGPMVVHCSAGVGRTGCFIVIDAMLE----------RMKH----EKTVD-
|.  .. |.|.  |.| ..   |  ||  |           | . |    . |..||||||||||| .. .| .|.          ....     || | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IYGHVTCMRSQRNYMVQTEDQYVFIHEALL
|   |  .|.||  |||. ||..||.||||
isiivnelrkqrismvqnldqfifiYeall
fn3 Fibronectin type III domain 419-504 3.6e-15 49.0 Pfam-A 1-85 (85) alignment 
Range on Protein: 419-504
Range on HMM: 1-85/85.0
SPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPpnAWHKHNTDAGL-LTTVGSLLPGITYSLRVLAFTAVGDGPPS
|.|......  ..... ..|.||....| . ||.| | ...     .|.  ....     |.  | || .|..|| | ...| ||.|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1810-1913 3.9e-15 50.4 In-house 217-343 (350) alignment 
Range on Protein: 1810-1913
Range on HMM: 217-343/350.0
IRQFQFTDWPEQGVPKTGEGFIDFIG--------QVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE----------RMR----YEGVVD-MFQTV
. |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.          ..|       . | ....|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KTLRTQRPAMVQTEDQYQLCYRAALEY
. || ||  |||. ||.  .| |.| |
nelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1672-1771 5.5e-15 49.6 In-house 89-181 (244) alignment 
Range on Protein: 1672-1771
Range on HMM: 89-181/244.0
ISANLPCNKFKNRLVNIMPYELTRVCLQpiRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrekCHQYWPAE
  |  | | .|||    .|... || |   .|  |  ||||||.    .   || || |||... |||.|. |    ..|.|  . |       .|||  
kdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1390-1513 7.3e-15 49.3 In-house 34-158 (332) alignment 
Range on Protein: 1390-1513
Range on HMM: 34-158/332.0
NKPKNRYANVIAYDHSRVILTSIDGVpgSDYINANYIDGYRKQNAYIATQGPLPE-TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCG
|   ||   . ..||||| |.  ||    |. ||...||| |..||| .| |. . |   ||||| |.. . ....  ..|| . |.      || |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

LIQV--TLLDTVELATYTVRTFALHKS
| ..    |. .|| .  .| |   |.
lhefgaksleecelkakicrkfwpekr
I-set Immunoglobulin I-set domain 135-216 7.9e-15 46.4 Pfam-A 1-82 (90) alignment 
Range on Protein: 135-216
Range on HMM: 1-82/90.0
PSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPatsNGRIKQLRSG---ALQIESSEESDQGKYECVATNSAGTR
|...  ..  .|..  .... | . |.|.|..||.||  .. .   . |.|   ..    | |.. |.||.|||.|.||||||..
pkftqklkdvevseGesvelectveGepepsvsWakdgselks...sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagka
subfamily_eak_pd Subfamily eak 1394-1549 3.7e-14 46.9 In-house 56-208 (332) alignment 
Range on Protein: 1394-1549
Range on HMM: 56-208/332.0
NrYANVIAYDHSRVILTSIDGVPgSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGT--ETCGLIQ
|   ... ||.  | |||    .   ||||  ..     . || |  .  . .  ||.|| ||.. ..|..    |.   | |.|.| ..      | ..
n.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPtPILAFLRRVK
|.  . |. . . .| . |.|    |  ..  ...  | .  .| |    ||. . .|
verkefvkrniletrllelskG..nethrvlhykvfGwtettlpkye.dflalrkvmk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1682-1904 3.9e-14 47.5 In-house 22-249 (290) alignment 
Range on Protein: 1682-1904
Range on HMM: 22-249/290.0
KNRLVNIMpYELTRVCLQPIRGVEGSDYINASFLDgYRQQKAYIATQGPLAES-------TEDFWRMLWEHNSTIIVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |...         |.|| |  . ... .||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  |.   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQ
.    .   .| | . . .|.|| ||  ..... .. 
lgyQkiaetsgsvkledvlkalrkqralaitsalela
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1547-1621 4.9e-14 46.9 In-house 220-293 (297) alignment 
Range on Protein: 1547-1621
Range on HMM: 220-293/297.0
RVKACNPLDAgPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 ..|  | .| ...|||||||||.|  .  |..|.......  |.   .. .|.||  .||| .|. ....| |.
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
fn3 Fibronectin type III domain 836-906 6.2e-14 45.1 Pfam-A 12-83 (85) alignment 
Range on Protein: 836-906
Range on HMM: 12-83/85.0
AMNTALLQWHPPKELPGELLGYRLQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGE
  ... |.| |||.  |.. ||...|. ... . .....  .. ...|.|||  ||.| ||..| |.|| |.
tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1852-1913 8.7e-14 45.6 In-house 2-63 (69) alignment 
Range on Protein: 1852-1913
Range on HMM: 2-63/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
||||.| |||| ||.. . . |.. | .||.|  |. .|  || ||  |..| . . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1851-1912 9.4e-14 45.6 In-house 2-63 (69) alignment 
Range on Protein: 1851-1912
Range on HMM: 2-63/69.0
TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 ||||.| |||| ||.. . . |.. | .||.|  |. .|  || ||  | .| . . |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_hpo-7_pd Subfamily hpo-7 1731-1899 1e-13 45.8 In-house 43-212 (263) alignment 
Range on Protein: 1731-1899
Range on HMM: 43-212/263.0
LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTIRQFQFTDWPEQGVPKTGE
| .  . |....   ... .|||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .|....... |.|.  |.  .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

GFIDFIGQVHKTKEqfgqdgpITVHCSAGVGRTGVFITLSIVLERMR------YEGVVDMFQTVKTLRTQRPAMVQT
  .  .  . . |.       . ||||.|.||.  |    .|  .|         . .|  . .. || .|.. ..|
eilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1346-1428 2.1e-13 44.4 In-house 5-85 (440) alignment 
Range on Protein: 1346-1428
Range on HMM: 5-85/440.0
PIPITDLADNIERLKAndGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDG
|| ..|.|| ..  .      | .|.  .  | .   . ..|  || |||| |..|||||||.|  . ||| |||||| ||.|
piivadfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1427-1508 6.2e-13 42.9 In-house 230-309 (440) alignment 
Range on Protein: 1427-1508
Range on HMM: 230-309/440.0
DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSrvkCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTF
.|| |.||.|||| ||  |. ||||.| . | .|..|. .|..|.   |  |||      | | . |    . ..    |||.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1657-1729 6.3e-13 42.7 In-house 28-95 (95) alignment 
Range on Protein: 1657-1729
Range on HMM: 28-95/95.0
EFKLL--ASSKAHTSRFISANLPcnkfKNRLVNIMPYELTRVCLQPIRgveGSDYINASFLDGYRQQKAYIATQG
||| .  .|  ..|     ||.|    |||..||.||. |||.|   |    |||||| |.||| ....|||.||
efksismtsgapytvgsseanip....knrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_eak_pd Subfamily eak 1682-1833 9.1e-13 42.3 In-house 55-203 (332) alignment 
Range on Protein: 1682-1833
Range on HMM: 55-203/332.0
KNrLVNIMPYELTRVCLQPIRgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. | .|  ||.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTgEGFIDF
|    |. . . ||.  ..   .  ..  .  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1679-1910 1.7e-12 41.6 In-house 47-275 (303) alignment 
Range on Protein: 1679-1910
Range on HMM: 47-275/303.0
NKFKNRLVNIMPYELTRVCLQpirgveGSDYINASFLDGYRQQKAyIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA-RYQ
|  |||.|...  . ..| |        | || ||.|.   ..|| | || ||. .. |||.|. | .   ...|    |. .   .  .| ..   ...
nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKTG-EGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
  .  |  . . .. .     .||    .|. .. .   .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .      
ersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

MR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA
.   .  .|. . ....|  |   ||   |. . |   
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll
I-set Immunoglobulin I-set domain 236-319 2.1e-11 35.4 Pfam-A 1-90 (90) alignment 
Range on Protein: 236-319
Range on HMM: 1-90/90.0
PRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNV----LELSNVVRS--ANYTCVAISSLGMIEATAQVTV
|.|.......||. | ||.|.| . | | | |.|. . .||...... |  .     |..||| .|   .|||.|  |.|  ||.|...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1682-1769 4.3e-11 36.7 In-house 51-154 (349) alignment 
Range on Protein: 1682-1769
Range on HMM: 51-154/349.0
KNRLVNIMPYELTRVCL----QPIRGVEGS----------DYINASFLDG--YRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| .|    .  .| ||||| ||  . .||....   .  ... |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1385-1464 7.1e-11 36.2 In-house 32-116 (347) alignment 
Range on Protein: 1385-1464
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDG-----VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
.. | .  |||  .|   | .||.|.  .       .   |||| .|     .. || || |||.|. |||.||   . . || .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1690-1822 1.6e-10 35.4 In-house 4-125 (130) alignment 
Range on Protein: 1690-1822
Range on HMM: 4-125/130.0
PYELTRVClqpirgveGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYN
..|..|.         | .||||||.    . . |. || |||... |||.|. |    ..|.|  . |       .|||       |.  ..  ... .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

MPQYILREF-KVTDARDGQSRTIRQFQFTDWPEQG
  ..|  .. .. .      ...  || ..|| .|
efknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1679-1763 1.9e-10 34.7 In-house 34-117 (332) alignment 
Range on Protein: 1679-1763
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYELTRVCLQPIRGVEgsDYINASFLDGYRQQKAYIATQGPLAESTED-FWRMLWEHNSTIIVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. |.. ..|...  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1843-1914 2.7e-10 34.1 In-house 261-344 (349) alignment 
Range on Protein: 1843-1914
Range on HMM: 261-344/349.0
QFGQDGPITVHCSAGVGRTGVFITLSIVLE--R--------MRYEGVV-D-MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.  |  .. |||||| |||||..|| ..|.           . .. .  | .. .| .|| || .|||   |.  .| | |.|.
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1653-1718 3.8e-10 33.7 In-house 23-86 (440) alignment 
Range on Protein: 1653-1718
Range on HMM: 23-86/440.0
AMELEFKLLASSKAHTSRFisANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGY
|.| |. || |. .. |    |.|| || |||  ||. |. .|| |. ..||  |||||||...| 
afedewsllpsglsqpsdi..aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1716-1795 5.7e-10 33.1 In-house 230-307 (440) alignment 
Range on Protein: 1716-1795
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  .  ||||.. ... . |.|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1375-1430 1.6e-09 31.8 In-house 24-78 (244) alignment 
Range on Protein: 1375-1430
Range on HMM: 24-78/244.0
DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDgVPGSDYINANYIDGYR
|  ..|   |. | .|  |||| |.. .|..||||.|     ||||||||||.| .
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq
subfamily_PTPDC1_pd Subfamily PTPDC1 1838-1907 2e-09 32.1 In-house 105-169 (182) alignment 
Range on Protein: 1838-1907
Range on HMM: 105-169/182.0
HKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVlermrYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .| .|. 
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvk
Ig_2 Immunoglobulin domain 142-223 2.1e-09 29.3 Pfam-A 8-78 (80) alignment 
Range on Protein: 142-223
Range on HMM: 8-78/80.0
QlKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNgrikqlrsgaLQIESSEESDQGKYECVATNSAGTRYSAPANL
.  ||..  . |. |.| |||.|...| ||  .... ...          | | . ...|.|.|.|.|.|| |   | . ..
p.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna..........lfipnvsaedsGtYtCrasnsegskqsnsvev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1518-1621 2.2e-09 31.1 In-house 217-342 (349) alignment 
Range on Protein: 1518-1621
Range on HMM: 217-342/349.0
KRELRQFQFMAWPDHGVPEYPTPILAFLRrVK--------ACNPL---DAGPMVVHCSAGVGRTGCFIVIDAMLE--RMKHE---------KTVD-IYGH
  || |.|.  |.| ..   |  ||  |  ||        | . |   .  ...|||||| |||| .. .| .|.   . ..         .. | |.  
PyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VTCMRSQRNYMVQTEDQYVFIHEALLE
|  .| ||  |||   |...|.||||.
vnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1412-1533 2.8e-09 31.4 In-house 7-125 (130) alignment 
Range on Protein: 1412-1533
Range on HMM: 7-125/130.0
IDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvkcDQYWPARGTET--CGLIQVTLLDTVELATYTVRTFA
.. ..| .||||...    . . |. || || .|  |||.|. |.    .|..  .||.     |.|||           | ||| |  |        . 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

LHKSGSSEKRELRQFQFMAWPDHG
 ..     .. |  ||   ||  |
iesdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1673-1772 5.6e-09 29.1 In-house 21-88 (169) alignment 
Range on Protein: 1673-1772
Range on HMM: 21-88/169.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAsfldgyrqqkayiatqgplaestedfwRMLWEHNSTIIVMLTKLremgrEKCHQYWPAER
 |.| ||. |||    .    ||| || .    |||||||                           ||.|| |...||.|        .   ..||   
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpeke
0038934 (Phosphotyrosine protein) phosphatases II 1818-1909 5.9e-09 31.3 In-house 85-172 (194) alignment 
Range on Protein: 1818-1909
Range on HMM: 85-172/194.0
W--PEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVL-ERMryegvvDMFQTVKTLRTQRPAMVQTEDQYQLCYRA
.  |..|.. . |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .. . ....|  || .... |...  .. 
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallkr
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1672-1771 6.4e-09 28.9 In-house 19-86 (169) alignment 
Range on Protein: 1672-1771
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAsfldgyrqqkayiatqgplaestedfwRMLWEHNSTIIVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |...||.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek
subfamily_PTPDC1_pd Subfamily PTPDC1 1524-1617 4.5e-08 27.7 In-house 85-170 (182) alignment 
Range on Protein: 1524-1617
Range on HMM: 85-170/182.0
FQFMAWPDHGVPEYpTPILAFLRRVKacNPLDAGPMVVHCSAGVGRTGCFIVIDAMlermkHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
.  ..|.|.||.   . ||   . |.    |. | . ||| || ||||  |    .     . | ..    .. .||.|   .|| .|  ...|
vynfgwkDygvasl.eriLdivkvva..falqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 1527-1610 7.1e-08 27.8 In-house 85-164 (194) alignment 
Range on Protein: 1527-1610
Range on HMM: 85-164/194.0
MAWPDHGVPEYPTPILAFLRRVKACNPLDA-GPMVVHCSAGVGRTGCFIVIDAMLeRMKHeKTVDIYGHVTCMRsqrNYMVQTED
. .||.|..     .| ||. |.  .  |. |  .||| ||.||||....   .  |..  .  . ..... .|   . .... |
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.rlgm.saeeAialfrekR...pgaipnqd
Ig_2 Immunoglobulin domain 49-124 7.5e-08 24.3 Pfam-A 16-80 (80) alignment 
Range on Protein: 49-124
Range on HMM: 16-80/80.0
VASFVCQATGEPKPRITWMKKGKKVSSQRFEviefddgagsvlRIQPLRVQRDEAIYECTATN-SLGEINTSAKLSV
   . |||.| |.|...| |.|...|... .             ..|.    |  .|.|.|.| .... ..| .. |
nvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv
Ig_2 Immunoglobulin domain 240-319 8.9e-08 24.1 Pfam-A 4-80 (80) alignment 
Range on Protein: 240-319
Range on HMM: 4-80/80.0
IPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTkedempVGRN--VLELSNVVRSANYTCVAIS-SLGMIEATAQVTV
. .....|  | .|.||| | | | | |.|  . |||.       ..|   . . ..  | .|||.|   ....   . .|||
lsapptvvtegenvtLtCqapgnptpkvqwykdgeels......qsqnalfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1433-1534 1.1e-07 25.7 In-house 137-235 (244) alignment 
Range on Protein: 1433-1534
Range on HMM: 137-235/244.0
NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvkcDQYWPARGT-ET-CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWP
  || || || .|  |||.|. |.    .|..  .||.     |.|||     |     | ||| |  |.       . .       .. |  ||   ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV
  | 
sdgt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1385-1481 1.6e-07 24.4 In-house 22-86 (169) alignment 
Range on Protein: 1385-1481
Range on HMM: 22-86/169.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAnyidgyrkqnayiatqgplpetmgdfwRMVWEQRTATVVMMTRLEEKSrvkcdQYWPA
..| .|. ||| |  .|  | || |  .    |||||||                           ||.||  .. .|..   ..|      ..|| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1669-1753 2.5e-07 24.5 In-house 27-116 (347) alignment 
Range on Protein: 1669-1753
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-----SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
|.| |..   .  |||  .    . ||| | | .   .       ||||| .     .| || || || ..  |||.|.   . | .| .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1385-1481 2.6e-07 23.6 In-house 21-85 (169) alignment 
Range on Protein: 1385-1481
Range on HMM: 21-85/169.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAnyidgyrkqnayiatqgplpetmgdfwRMVWEQRTATVVMMTRLEEKSrvkcdQYWPA
..| .|. ||| |  .|  | || |  .    |||||||                           ||.||  .. .|..   ..|      ..|| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpe
subfamily_eak_pd Subfamily eak 1544-1622 3.5e-07 23.9 In-house 226-304 (332) alignment 
Range on Protein: 1544-1622
Range on HMM: 226-304/332.0
FLRRVKACNPLDAgPmVVHCSAGVGRTGCFIVIDAMLeRMKHEKTVDIY---GHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.|.. .   |  | | .. .. |  |.| |.||| .. |.  .|  . |     .  ..|.|.. | .. |. ||.|..|. 
tlkkyihtppsfa.p.iiqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
Ig_3 Immunoglobulin domain 148-211 1.5e-06 20.4 Pfam-A 17-75 (75) alignment 
Range on Protein: 148-211
Range on HMM: 17-75/75.0
KartATMLCAAGGNP-DPEISWFkdfLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATN
.    |  | | |.|  | |||       .|  .. ...   .. | |.|  ..| | |.|||.|
n...vtLtCsaeggpppptisWy...ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_PRL_pd Subfamily PRL 1839-1885 2.5e-06 21.6 In-house 82-128 (151) alignment 
Range on Protein: 1839-1885
Range on HMM: 82-128/151.0
KTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT
|.| .   .  ..||| ||.||. |...|... . |.||  |.. ..
kekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefire
Ig_3 Immunoglobulin domain 38-111 4.6e-06 18.8 Pfam-A 6-75 (75) alignment 
Range on Protein: 38-111
Range on HMM: 6-75/75.0
VPEDQTGLSGGVASFVCQATGEP-KPRITWMkkgkKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAiYECTATN
|.  .|  |||  .. |.|.| | .|.|.|.    .  .. ..  |  .. .|.| | .   . .   |.|.|.|
vspsptvtsggnvtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvtsedsGt.YtCvasN
PTPc_motif_SM00404 1803-1899 5.6e-06 21.3 In-house 42-127 (140) alignment 
Range on Protein: 1803-1899
Range on HMM: 42-127/140.0
RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRTGVFItlsiVLERMRYEGVvDMFQTVKTLRTQRPAMVQT
.  ....| | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||... .. . .. .. .||.. ..
kensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrql.slaeayefvkerRpiispn
Ig_3 Immunoglobulin domain 236-304 5.9e-06 18.4 Pfam-A 2-73 (75) alignment 
Range on Protein: 236-304
Range on HMM: 2-73/75.0
PRFSIPPSSQEVMPGGsVNLTCVAVGAP-MPYVKWM-MGAEELTKEDEMPVGRNVLELSNVV--RSANYTCVA
|  |..||. ..  |. |.||| |.| |  | . |.  .  || . .    . ..| .|.|    | .|||||
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCva
subfamily_CDC14_pd Subfamily CDC14 1847-1905 6.9e-06 20.1 In-house 263-316 (328) alignment 
Range on Protein: 1847-1905
Range on HMM: 263-316/328.0
DGPITVHCSAGVGRTGVFITLSIVlERMRyegvVDMFQTVKTLRTQRPAMVQTEDQYQL
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  |  |
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqqkfl