Gene PTPRF in Homo sapiens

Synonym: BNAH2, LAR, RP5-1029K14.1, PTPRF

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP097_AA protein Get Run
HsapP097_AA_1349-1624 phosphatase_domain Get Run
HsapP097_AA_1636-1915 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1344-1674 2e-169 559.9 In-house 2-333 (564) alignment
Range on Protein: 1344-1674
Range on HMM: 2-333/564.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
..|||...|.. ...||||..|||..||..|..|||||||..| ..||.||||||..|||||||.|....|..|||||||..||||||..|||||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILA
||. |||||||||...|.||.|.||||..|||..|||..||||.| ..||| ...|||.|..||| |.|. |||.|| |||.|..||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
..|.|.|.|. ||||.||||||||||||.||||||||||.|.|||||||..|...|.|||.|||||.||.|||||.||| .||.|||...||..|.||| 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QVPPGESVTAMELEFKLLA-SSKAHTSRFISA
.| .....| .||||. || ... ....| .|
eveedtemtgleleFqrLatakeieleefava

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1347-1660 2.3e-131 432.6 In-house 2-317 (318) alignment
Range on Protein: 1347-1660
Range on HMM: 2-317/318.0
IPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|.. ||.....||...  |..|.||| ...  ...|. .|. .||| ||||||..||||.|| |. ..|..||||||||||||||...||||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
. ||||||||| .|..||.|..||....|...||| .|... | ..|.| ..|||..|..|.| .......|.|. ||... .|||.|||| .. .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKACN-PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ
|.|.. . . .|||.|||||||||||| ||..|..|||.|.|..||... |. .|.||| ||||||||.||...|||| ..|.||| |..| ..|..| .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

VPPGESVTAMELEFKL
. |    | |..||. 
qdpesgttemdaefqr

subfamily_PTPRD_pd Subfamily PTPRD 1667-1919 8.4e-127 419.1 In-house 36-286 (564) alignment
Range on Protein: 1667-1919
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|. .||.|....|.||||||||||.||||..||||||||||||..||||||.||.||..|||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||..|||.||.||..|||.......|.| .|....|   . |||.|||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH
....|||...|..||..|.||.||.||.||||||.||. ...| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1346-1659 1.5e-116 384.0 In-house 4-319 (319) alignment
Range on Protein: 1346-1659
Range on HMM: 4-319/319.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
.|.. .|......|...   .. .|.. .. ....|..... | ||.|||| |..|||..||.|...|||.|||||||..||||......||||.|| .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAF
. ||||||||... .|||.|.| || .||. .|||    |. | . |||..  ||. | .| . |.| |.  | ||. .||...||||.|||. | .|..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
|.|..      ..||.|||||||||||| |||.||||||.|.| ..|..  |  .| ||| |||...|| ||.||||||...|.||.  ..|   ...| 
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QVPPGESVTAMELEFK
.  ..   | .| ||.
ekvadtgetglerefq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1652-1921 9.1e-114 374.8 In-house 20-287 (318) alignment
Range on Protein: 1652-1921
Range on HMM: 20-287/318.0
TAMELEFKLLASSKAHTSRFISaNLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
. .. |.. |. |....... | . |.||.||| .||..|. ||| ||.. |.||||||||...||||..|||||.|.||.|  ||||||.|| ||..||
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdGPIT
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||..||...|.||..|||. | ...|...||.|.... |. |||.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..||||||||...| . ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

subfamily_PTPRA_pd Subfamily PTPRA 1339-1658 9e-112 368.2 In-house 6-330 (330) alignment
Range on Protein: 1339-1658
Range on HMM: 6-330/330.0
SSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIA
|. . ..|.|. .| ..|.. .|.|  .| .|....     | | | .. | || |||. |.. ||.|||||. ..||. |||||| .||||.... .||
sgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSS----EKRELRQFQFMAWPDHG
.|||. ||. |||||.|||..||.||.| |.|. . || ||||  |. | | |.|.. |...|  |||| | ... . .    ..| .||| | .||| |
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

VPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPAR
||  |  .| .|..||..|.  |||.|||||||||||| |||.||.|||.| |. ||... |  .| ||  ||||. ||.||...|||    | ||. . 
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs

NLYAHIQKLGQVPPGESVTAMELEF
 |  |.||| .  .| . ...| ||
slekhlqklynkitgtdkigleeef

0040438 (Phosphotyrosine protein) phosphatases II 1349-1661 1.4e-111 368.0 In-house 2-314 (317) alignment
Range on Protein: 1349-1661
Range on HMM: 2-314/317.0
ITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGD
..|| . ...|...|  ....|.| ..  .  |.. ..|..||.|||| ... ||||||.|....|...||||||.|.||.......||||||||.|..|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV
||||||||.. ..||.|.|||..|.||.|||| ..| |.| ..||||...||| .|.||. . ..|.||.|....|....|||||||..|...|.||..|
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPG
..... . ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|...||||  ....| .|| .|. ...|| .....
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

ESVTAMELEFKLL
..|. .| |.|||
ddvklkekelkll

subfamily_PTPRG_pd Subfamily PTPRG 1347-1635 1.6e-111 368.3 In-house 1-299 (563) alignment
Range on Protein: 1347-1635
Range on HMM: 1-299/563.0
IPITDLADNIERLKANDGLKFSQEYESID---PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGS-DYINANYIDGYRKQNAYIATQGPL
.|. ..|  .  |.|..  .||.|.|..      .... | |. . || |||| |..|||.||| |... |. .. |||||||||||.|..|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK----SGSS--EKRELRQFQFMAWPDHGVPE
..|. |||||.|||..|..||.| |.|. | |||.|||. ..||.| .|||| ..  ||.|||||. ...     ...  .... ||...  ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
...| | | .. .| |. .|||.|||||||||||| .||.|..|.....|..|...| .  .|.|||..||||.||.|.|.||||| . ..||. | ..
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

subfamily_PTPRK_pd Subfamily PTPRK 1344-1645 7.2e-110 361.7 In-house 1-299 (314) alignment
Range on Protein: 1344-1645
Range on HMM: 1-299/314.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGqqftWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
|| | . || ..|  ||...|  | .||||.  |    |. .. . |. |||. ...|||.|||.|..||| | ||||||..||.|.. .|.|.|||||.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTEtCGLIQVTLLDTVELATYTVRTFALHK--SGSSEKRELRQFQFMAWPDHGVPEYPTPI
||. ||||.|.....|..||.| | |..|||| .|||  ..   | |.|.|..|  || . ||.|...|   | .|.||.|||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK
|...||||. .. .||..||||||| ||||.||.|| .|. ...|..||..  |  .||..  ||.||.||.||....|||. ||.| .|. .. |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LGQV
  ..
sirl

0051299 (Phosphotyrosine protein) phosphatases II 1344-1623 1.9e-108 357.6 In-house 2-286 (288) alignment
Range on Protein: 1344-1623
Range on HMM: 2-286/288.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL
. .|....|.. ...|.||.  .. .|.| . . . ..|.  ..|. |..|||| ....||||||.|...|||.|||||||.|||||......|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS----GSSEKRELRQFQFMAWPDHGVPEYP
|.|..|||||||||.. ..||.|.|.|..|.||.|||| .|..|.| |.||||....|..|||||. . .     |..|.|. ..|....|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
...|.|||.|. ... . ||.||||||||||||.||..| .||....|..||... |  .|.||..||||..||.|..|||||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRB_pd Subfamily PTPRB 1345-1624 1.2e-107 354.3 In-house 5-286 (293) alignment
Range on Protein: 1345-1624
Range on HMM: 5-286/293.0
PPIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
 || ...... ....||.. |.||.|||..   |.. . . ..|.||. |||| |...|||||| |..... .||||||||||.||. .. .||||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR-GTETCGLIQVTLLDTVELATYTVRTFALHKsgSSEKRELRQFQFMAWPDHGVPEYPTPIL
||. ||||||||... ..||.|.| || .|||..||||   . . | |.|||. . ||  ...|.....|  ..|.|..||..|..|||||||| ....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKACN--PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT
.|.|.|.       ...|.|||||||||||| || .| .|.....| .|||.| |. .|..||..||||.||.|||...|.  .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

0050432 (Phosphotyrosine protein) phosphatases II 1333-1627 1.4e-106 351.6 In-house 12-303 (308) alignment
Range on Protein: 1333-1627
Range on HMM: 12-303/308.0
PSCPNTSSMRDHPPIPITDLADNIERlkANDGLKFSQEYESIDPGQQ-FTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGvPGSDYINANYIDGY--
. . .|| .  . .... ||.  .|.  |.|  ....|.| .   .  .... ..|. ||.|||| ....||||||.|    . .|||||||.|.|||  
llfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR---GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQF
......||||||||.|..|||||||||.. ..||.|.|.|..|.||.||||     |....| ..||||.. .|..|||||. | ..|..| |....|..
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

MAWPDHGVPEYPTPILAFLRRVKACNplDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
..|||||||..|...|.||..|. ..  . ||.||||||||||||.||..| .||....|..||... |  .|.||..||||..||.|...|||| . . 
tnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

H
 
l

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1359-1630 3.2e-104 343.4 In-house 21-297 (298) alignment
Range on Protein: 1359-1630
Range on HMM: 21-297/298.0
LKANDGLKFSQEYESIDPGQQ----FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVW
 |...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|...|.   |||||| ....|...||.||||.||.||. ||||||.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAcNPL
|.  .|.||.| |||. ..|. .||| .|.|| | |.|.|| . | | ..||.....|. ....||.||..|. |||.||||. | .|..||.|.| .. 
eedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

DAG--PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
.||  |..|.|||||||.| ||.||..|||.|.|..||..  |  .| .|  .||||.|||||.|| ||| ... .|.
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1650-1918 2.9e-101 333.7 In-house 21-287 (319) alignment
Range on Protein: 1650-1918
Range on HMM: 21-287/319.0
SVTAMELEFKLLASSKAHtsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. | .| |||||  ...    | ||. . || |||  ||..|. ||| |... ||||||||||||.|||......||||.||.. .||||||.||..| |
getllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

IVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDG
.|||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.. .||.|.||...||... . .|......|..|.  |.|
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsg

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
||.||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||...||...| | ||.. ..|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0051299 (Phosphotyrosine protein) phosphatases II 1626-1914 3.4e-101 333.7 In-house 1-286 (288) alignment
Range on Protein: 1626-1914
Range on HMM: 1-286/288.0
GHTEVPARNLYAHIQKLGqvppGESVTAMELEFKLLASSKAHtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYI
|.||.....|. ...||       ..| .. ||. | | ...   . .|.||.|. ||| ..|.||. .||.|... |||||||||||..|||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQ
|||||| ...||||||.||.|...||||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.|||...|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||| . | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||..||...|.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 1346-1621 1.9e-100 331.2 In-house 1-275 (278) alignment
Range on Protein: 1346-1621
Range on HMM: 1-275/278.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
||.. ||.. ...|..|.  ....|.|...  . .|.. ..|. ||.|||| ....||||||.|....|...||||||.|.|||......||||||||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPaRGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
..||||||||... |.||.|.|.|..||||.|||| .|..|.| ..||||.. .|..|||||. ... |..|.|. .......|||||||| ....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|. ... . ||..|||||||||||.||... .||....|..||..  |  .|.||  .|||..||.|..|||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 1367-1629 2.4e-100 330.8 In-house 2-280 (284) alignment
Range on Protein: 1367-1629
Range on HMM: 2-280/284.0
FSQEYESIDPGQQF---TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYIDGY-----RKQNAYIATQGPLPETMGDFWRMVWEQR
. .|.| .   . .   ... ..|. |. |||| ....||||||.|.|.||  ..||||||.|.|||     ......||||||||.|..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TATVVMMTRLEEKSRVKCDQYWPARG-TETCGLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP--
. ..||.|.|.|..|.||.||||  | . |.| ..||||.. .  .|||||. | . | ..| |....|....|||||||..|...|.||| |. ...  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEK---TVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTE
 . ||.||||||||||||.||..| .||....|.   .||... |  .|.||..||||..||.|..|||||.. ...| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

0050432 (Phosphotyrosine protein) phosphatases II 1649-1919 2.9e-100 330.9 In-house 39-304 (308) alignment
Range on Protein: 1649-1919
Range on HMM: 39-304/308.0
ESVTAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGvEGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHN
 . . .| ||. | | |     . .|.||.|| ||| ..|.||. .||.|    . |||||||||. |||  ......||||||| ...||||||.||.|
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

STIIVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeq
...||||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.|||...|..|.||..|||   | ..||. .|.|.   
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

fgQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH
  ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||..||...|||.|||| .. .
..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 1360-1638 1.4e-99 328.4 In-house 8-292 (297) alignment
Range on Protein: 1360-1638
Range on HMM: 8-292/297.0
KANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT
|...  ....|.|...| . ..... ..|. |..|||| ....|||.||.|    . .|||||||.|.|||. ....||||||||.|..|||||||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

ATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVE--LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL
 ..||.|.|.|. |.||.||||    .. |.| ..||||.. .  |..||.||. . . |..|.|....|... ||||||||.|...|.|...|. ...|
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--DAGPMVVHCSAGVGRTGCFIVIDAMLERMK---HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
  . ||..|||||||||.|.||..| ||....   .|..|||.  |  .|.||. .|||..||.|..|||||   .. | .|...|. .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll

0039614 (Phosphotyrosine protein) phosphatases II 1338-1627 6.4e-99 326.4 In-house 5-293 (297) alignment
Range on Protein: 1338-1627
Range on HMM: 5-293/297.0
TSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQfTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYIDGYRK-QNAY
.... ...|||.. |.  . ..|||.  .. .|.|..   .   .. ..|..||.|||| ....||||||.|...||| ..||||||.|.|||.. ....
rdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

IATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTeTCGLIQVTLLDTVELATYTVRTFALHKsgSSEKRELRQFQFMAWPDHGVP
||||||||||..|||||||||.. ..||.|.|.|..| ||.|||| .|. |.| ..||||.. .|. |||||. . .  ..| |....||.. |||||||
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvp

EYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGH
.... .| ||. |. ..    . ||..|||||||||||.||... |||....|..||..  |  .|.||...|||..||.|...||||   ...
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0047943 (Phosphotyrosine protein) phosphatases II 1361-1621 3.9e-97 320.2 In-house 8-270 (273) alignment
Range on Protein: 1361-1621
Range on HMM: 8-270/273.0
ANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILtsidGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTA
...  .. .|.| . . . ..|.. ..|. || |||| ....||||||.|    | .|||||||.|.|||......||||||||.|..|||||||||.. 
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TVVMMTRLEEKSRVKCDQYWPARG---TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--
..||.|.|.|..|.||.||||  |   ..|.| ..||||.. . ..|||||. | ..|..|.|. ..|... |||||||......| |.. |. ..    
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
. ||.||||||||||||.||..| .|.....|..||..  |  .|||| .||||..||.|..|||||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0045450 (Phosphotyrosine protein) phosphatases II 1341-1621 6.4e-97 320.2 In-house 3-302 (307) alignment
Range on Protein: 1341-1621
Range on HMM: 3-302/307.0
MRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQF---TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGV-PGSDYINANYI--------DG
.  ...|....|   . .|....  .. .|.|.. . . |   ... ..|..||.|||| ....|||.||.|.|.||  ..||||||.|.        ||
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE-TCGLIQVTLLDTVELATYTVRTFALHKS-GSSEKRELRQFQF
|......||||||||||. |||||.|||.. ..||.|.|.|. |.||.||||  |.| |.| ..||||.. .|. |||||. .. . |..| |....|..
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

MAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .|||||||... ..|.|...|....    . ||..|||||||||||.||... ||.....|.|   ||..  |  .|.||  .||...||.|..|||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle





subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1354-1623 1.5e-96 317.8 In-house 10-279 (288) alignment
Range on Protein: 1354-1623
Range on HMM: 10-279/288.0
DNIERLKANDGLKFSQEYESI-DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRM
... . .|..   ||.||.|.   ... . . ..| ||..|||| |...||. || |.  . ..|.|||||.||||..|...||||||||..|..|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQRTATVVMMTRLEEKSRVKCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC
|.|..| |.||.| | |. . ||..|||. .. .  | ..|||... ||  ...|.. |.|.   ...|. |.|..|||||||||  .|.|..|| ||  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkva

NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
|. |.||..||||||||||| ||..||.......|...|. | |. .| ||. .|||. ||.||.|.||. .
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1626-1921 2.3e-96 317.6 In-house 1-297 (298) alignment
Range on Protein: 1626-1921
Range on HMM: 1-297/298.0
GHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKA--HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKA
| ||. |..| |..||| .| . ...| ..|||. | | .   ..     |. | || |||  .|.... .|| |. . . | |||||||||..|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGV
.||||.|| |..||||||..|.... |||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|..||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
|.. .  .|.. .|.....| | . |..|.|||||||.| || .. ||||.. | |||.||.||.||..||..||||.||  .| | ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0046845 (Phosphotyrosine protein) phosphatases II 1654-1917 5.5e-96 316.5 In-house 2-277 (284) alignment
Range on Protein: 1654-1917
Range on HMM: 2-277/284.0
MELEFKLLASSKAHTS-RFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFLDGY-----RQQKAYIATQGPLAESTEDFWRMLWEHN
.| ||. | | . . .  .  |.||.|. ||| ..|.||. .||.|... |  |.|||||||..|||     ...|..||||||| ...||||||.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF
...|||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.|||...|..|.||..||| . | ...|. .|..  |..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEG---VVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
...||| |||||||||||.||.| ..||....||   .||....|| ||.||| ||||..||...|.|.|||| ..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0040438 (Phosphotyrosine protein) phosphatases II 1652-1914 2.1e-95 314.9 In-house 18-276 (317) alignment
Range on Protein: 1652-1914
Range on HMM: 18-276/317.0
TAMELEFKLLASSKAHtsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
||.. ||. | | | .   .  |.||.|| ||| ..|.||. .||.|.|. |...|||||||. ||.......||||||| ...||||||.||...|.||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPIT
|||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..|||...|..|.||..|||.. . ..||. .|..  |  ...||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||. .|.|.||||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1346-1642 8.6e-95 312.4 In-house 3-302 (305) alignment
Range on Protein: 1346-1642
Range on HMM: 3-302/305.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGqQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
.| . |||  |.  ....  .. ..|.|.    . . .  . |.|| |||..... .|..|.|||  . .. ||||||.|.|||.....||..||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE--TCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPIL
. ||||...| .. |.||.|.| |  . || |||| . ||    | ..|.| .. . . |. | . . . ....|.| . |.|.  |||||||...| .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFLRRVKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQK
 ...||.     | | |..||||||||||| ||..| .|||.|.|..||... .  .||.| .|||| |||||.|.|| |  |||.|..   || |...|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

L
|
l

0047943 (Phosphotyrosine protein) phosphatases II 1650-1914 1.3e-94 311.9 In-house 10-272 (273) alignment
Range on Protein: 1650-1914
Range on HMM: 10-272/273.0
SVTAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
..| ...||.|| | |     .  |.||.|| |||  .|.||. .||.|    | .||||||||..|||......||||||| ...||||||.||.|...
gltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ
|||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.|||...|..|.||..||| . | ...|| .|.|. |.. .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.||. |||||||||||.||.| ..|.....|| ||....|| ||.||| ||||..||...|.|.||||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 1657-1913 1.6e-94 311.5 In-house 37-294 (330) alignment
Range on Protein: 1657-1913
Range on HMM: 37-294/330.0
EFKLLASSKAHtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | ... . . .  |.   || |||.|||.||. .|| |....||| ||||||||.|||.... .||.|||..|. ||||||.||..|. |||||.|
efnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

REMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdgPITV
.|  .|||.|||| | .  |    |    |  . .| .|.| |..     |. .|| .||| || ||. ||| .. | .... .|.|...| ..  ||.|
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivv

HCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
|||||||||| ||.|. ||||.. |..||.|..|| ||.||| ||||. ||...|.. |||
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

0039614 (Phosphotyrosine protein) phosphatases II 1650-1917 1.4e-93 308.9 In-house 30-292 (297) alignment
Range on Protein: 1650-1917
Range on HMM: 30-292/297.0
SVTAMELEFKLLASSKAHtsrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNS
| | ..|||. | | |     .  |.||.|| ||| ..|.||. .||.|.|..|| ..|||||||..|||.. ....||||||| |..||||||.||...
sktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

TIIVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
|.||||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.|||...||.|.||. ||| . | ...|. .|..  .. ...
tvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||..||. .|.|.||.|  .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

DSPc_SM00195 1367-1622 5.3e-93 306.5 In-house 2-261 (263) alignment
Range on Protein: 1367-1622
Range on HMM: 2-261/263.0
FSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
...|.|...  . . . .... . || |||| |.. |||.||.|..... .||||||||||.|..|...|||||||||.|. ||||||||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELA-TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
. ||. . |||.|||    |.|| | |.|.| .. .    ...||. | | | .|.|...|.|. .|||||||. ....|..|| || ..    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||||||.|..|| .|.....||.|||   |. .|.||  ||||..|| ||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 1367-1622 5.3e-93 306.5 In-house 2-261 (263) alignment
Range on Protein: 1367-1622
Range on HMM: 2-261/263.0
FSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
...|.|...  . . . .... . || |||| |.. |||.||.|..... .||||||||||.|..|...|||||||||.|. ||||||||... ..||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELA-TYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
. ||. . |||.|||    |.|| | |.|.| .. .    ...||. | | | .|.|...|.|. .|||||||. ....|..|| || ..    ||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||||||.|..|| .|.....||.|||   |. .|.||  ||||..|| ||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0043336 (Phosphotyrosine protein) phosphatases II 1650-1914 6.4e-93 306.5 In-house 18-277 (278) alignment
Range on Protein: 1650-1914
Range on HMM: 18-277/278.0
SVTAMELEFKLLASSKAhtSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. |...|||. | | |     .  |.||.|| ||| ..|.||. .||.|... |...|||||||..|||......||||||| |..||||||.||...|.
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGP
|||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.|||........||..||| . . ..||. .|..  |   ..||
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngp

ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
. |||||||||||.||.| ..||....|| ||....||.||.||| .|||..||. .|.|.||||
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 1652-1917 1e-92 305.9 In-house 13-280 (297) alignment
Range on Protein: 1652-1917
Range on HMM: 13-280/297.0
TAMELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLqpirGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
. .. ||. | . ..    .  |.||.|. |||  .|.||. |||.|    . |||||||||..|||......||||||| ...||||||.||.|.|.||
alllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
|||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.|||...|..|.||. ||| . . ..||| .|.|  ... ..
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

GPITVHCSAGVGRTGVFITLSIVLERMR---YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF
||. |||||||||.|.||.. ..|....   .|| ||....||.||.||| .|||..||. .|.| ||.| ..
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0045450 (Phosphotyrosine protein) phosphatases II 1646-1914 2.5e-92 305.2 In-house 21-304 (307) alignment
Range on Protein: 1646-1914
Range on HMM: 21-304/307.0
PPGESVTAMELEFKLLASSKAH-TSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV-EGSDYINASFL--------DGYRQQKAYIATQGPLAEST
 . ...| .. ||. | | . .    . .|.||.|| ||| ..|.||. |||.|... |  |.|||||||.         |||......||||||| |. 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

EDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDF
|||||||||...|.|||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.|||...|..|.||..|||.. | ..||
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

IGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||...||. .|.|.||.|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1389-1625 4.9e-92 302.6 In-house 8-244 (250) alignment
Range on Protein: 1389-1625
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVkCDQYWPARGTETCG
 || |||||..||.|.|||.| . .|   |||||| ...||....|.|||||||..|. ||||||.|. ..|.||.| |.|. .. . ||||. ..|. |
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL-DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEK
 ..|.||.. | | ||.|.. | |   ...| .||..|..||| ||||. | .|..|..|.| ..  ...|..|.|||||||.|.||.|||.|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
.||..  .  .| .|  .|....||||..|..|.| ..
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1366-1642 5.2e-92 303.5 In-house 35-310 (319) alignment
Range on Protein: 1366-1642
Range on HMM: 35-310/319.0
KFSQEYESI--DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVM
|.  |.  .   . .  . . .||. || |||. |..|.|...| |  ..|. .|||||| ...||.... |||.||||..|. |||||.||....|.|.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

MTrleeksRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD--AGPMV
.|      . || |||| .. .. .  .| .    | | |.|| . | . .   ..|...|| |. |||.|||.||.... ....|.  .       ..|
lt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKL
||||||||||| .||.|..|.|||.|| ||.|  |  .| ||| .||   || ||. ||||    ||..|   .. |....|
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1344-1638 8e-92 302.5 In-house 3-293 (315) alignment
Range on Protein: 1344-1638
Range on HMM: 3-293/315.0
HPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
| |||. .|   . . ||.    | |.||||  || .  . ..   || |||| |.||||.||| |  ..  |.|||.|||.|||| |.. |||.|||..
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARgTETCGLIQVTLLDTVELATYTVRTFalHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILA
....||||.|.|.  ...||.| | |. . |...||| .   . | | ||. .      |||||.       .. ||. |... .||| |||.| .|.. 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmn

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVpARNLYAH
. |.||  .  ..|..|||||||||||| || .||.|.... |. .|.|  .| .|..|  |||. .|| ||..||||.  || | . |..|| .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdlylq

0040439 (Phosphotyrosine protein) phosphatases II 1381-1621 1.4e-90 298.5 In-house 2-244 (249) alignment
Range on Protein: 1381-1621
Range on HMM: 2-244/249.0
TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP
... ..|..||.|||| ....||||||.|....|...||||||.|||||. ....||||||||||..|||||.||..  ..||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDA
 .|. ..| ..||||.. ... |||||. |.... .|.|. ...|.  |||||||... ..|.|...|. ..    . ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
|||....|..||..  |  .||||...||...||.|..|||||
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1382-1642 2.2e-90 298.0 In-house 17-274 (284) alignment
Range on Protein: 1382-1642
Range on HMM: 17-274/284.0
WENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTrleeksRVKCDQYWPA
 . .||. || |||. ...|.|...| |  ..|. .|||||| .| ||.... ||||||||..|. |||||.||....|.|..|      . || |||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

RGTETCGLIQVTLLDTVELATYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD--AGPMVVHCSAGVGRTGCFIVIDA
.. .. .  .| .    | . |.|| . | . .   ..|..||| |. |||.|||.||.........|.  .       ..|||||||||||| .||.|.
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKL
.|.|||.|| ||.|  |  .| ||| .||   || ||. ||||    ||..|   .. |....|
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel

0040439 (Phosphotyrosine protein) phosphatases II 1672-1914 7.3e-90 296.1 In-house 4-246 (249) alignment
Range on Protein: 1672-1914
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||. .||.|....|...|||||||..|||......||||||| |..|||||||||...|.|||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.|||....|.||||..|||.. | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|....|. ||....||.||.||| .||...||. .|.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

DSPc_SM00195 1657-1914 4.4e-89 293.7 In-house 5-262 (263) alignment
Range on Protein: 1657-1914
Range on HMM: 5-262/263.0
EFKLLASSKAHTsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | .|. .. .. .|. . || |||  ||.||. ||| |... . ||||||||....|....|.|||||||| .  |||||| ||....||||||. 
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

REMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDGPITVH
 | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|...|.|...||..|||.. . ..... .|.|.|..   .||| ||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVh

CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||.|.|..|.|.... |  ||.|..|| ||.||| ||||..||. .|.|.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1657-1914 4.4e-89 293.7 In-house 5-262 (263) alignment
Range on Protein: 1657-1914
Range on HMM: 5-262/263.0
EFKLLASSKAHTsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
||. | .|. .. .. .|. . || |||  ||.||. ||| |... . ||||||||....|....|.|||||||| .  |||||| ||....||||||. 
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

REMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDGPITVH
 | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|...|.|...||..|||.. . ..... .|.|.|..   .||| ||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVh

CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||||.|.|..|.|.... |  ||.|..|| ||.||| ||||..||. .|.|.|||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

Y_phosphatase Protein-tyrosine phosphatase 1390-1621 6.3e-89 292.8 Pfam-A 1-235 (235) alignment
Range on Protein: 1390-1621
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILtsiDGVPG-SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP--ARGTET
|| |||| ....||..|| |   .| .| ||||||||..||......|||||||..|..|||||||.... ..||.|.||||.|.||.||||   ....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGLIQVTLL-DTV-ELATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM
.| |.|.|  ..  . . ||.|.. |.|.... ||||..|... .|||||||| |...| ..|.|.  .  . ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|..||..  |  .|.||. |||...||.|...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1390-1621 6.3e-89 292.8 In-house 1-235 (235) alignment
Range on Protein: 1390-1621
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILtsiDGVPG-SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP--ARGTET
|| |||| ....||..|| |   .| .| ||||||||..||......|||||||..|..|||||||.... ..||.|.||||.|.||.||||   ....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CGLIQVTLL-DTV-ELATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM
.| |.|.|  ..  . . ||.|.. |.|.... ||||..|... .|||||||| |...| ..|.|.  .  . ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|..||..  |  .|.||. |||...||.|...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Ptp69D_pd Subfamily Ptp69D 1345-1642 9.3e-89 292.6 In-house 2-305 (307) alignment
Range on Protein: 1345-1642
Range on HMM: 2-305/307.0
PPIPITDLADNIERLKANDGLKFSQEYESID-PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLP
..|.| ||.....  | .    . .|||..     . . ..|. . |. |||| ...|.|. ||.|. | |   ||||||..| ||.... .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSG-----SSEKRELRQFQFMAWPDHGVPEYP
.|.||||||..||   ..||.. |.||.| ||..|||   .   | | |.| .. .   |. |.. . | .       ..|.. |.....|.|  ||| .
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
. .| ....|.  . |. .|.||||||||||.| |. .| .|...| |..|||.  |  .||||| .||  .||||.. |||.  . |.|..  ..|  .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKL
|..|
ierl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1353-1622 2.5e-88 290.9 In-house 3-275 (281) alignment
Range on Protein: 1353-1622
Range on HMM: 3-275/281.0
ADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWR
  ....|..||   | .|||..   |.. | . |. . |. |||| |..|||..|| .|  .    .||||||...||.....|||||||.|... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQRTATVVMMTRLEEKSRVKCDQYWPARG-TETCGLIQVTLLDTVELATYTVRTFALhKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKA
|||||.  ..||.||  |....|| .|||    . . | ..|. . . | |||  |.| | .  |.|.||..|....||||||||. .. .| | . |. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

CNPLDA-GPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
..  .   |.|.||||||||||..| .| .......| ...|.   |. .| .||.||||  || |.. |.|.|
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

0042113 (Phosphotyrosine protein) phosphatases II 1383-1621 2.6e-88 290.8 In-house 2-241 (245) alignment
Range on Protein: 1383-1621
Range on HMM: 2-241/245.0
ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR
. ..|..||.|||| ....|||.||.|....| ..||||||.|.||||  . .|||||||||| .|||||.||..  |.||.|..||..||||.|||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLE
.. |.| ..||||..  |..|||||. ... |..|.|| ...... |||||||...  .| ||..|. .    . ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
....|..|...  |  .||||  .|||..||.|..|||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 1369-1624 2.8e-88 291.1 In-house 12-273 (278) alignment
Range on Protein: 1369-1624
Range on HMM: 12-273/278.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVIltsidgvpgsDYINANYIDGYrkQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLE
. .. . .|.  ........ |..|||| ....||||||.          |||||.|||||  ....||||||||.|. |||||.||... ..||.|.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS----GSSEKRELRQFQFMAWPDHGVPEYP--TPILAFLRRVKACNPL--------
|..|.||.|||| .|..|.| ..||||.. .| .||.||. ..       . |.|........ |||||||..|  ...| .|....... |        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----DAGPMVVHCSAGVGRTGCFIVIDAMLERMkhEKTVDIYGHVTCMRSQRNY-MVQTEDQYVFIHEALLEAAT
     . ||..|||||||||||...... |||..  |..||..  |. .||||.. .||...||.|..|.|||   
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPRB_pd Subfamily PTPRB 1657-1914 1.9e-87 288.0 In-house 30-285 (293) alignment
Range on Protein: 1657-1914
Range on HMM: 30-285/293.0
EFKLLASSKaHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKL
|.. | . . ..    .|.|..|. |||  ||.||. .|| |..... .|||||||....||.... .||||||| |...|||||.||..|.||||||.|
eyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

REMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCS
 | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|..||..|| ||. |||.. . ..||. .|....|.  ...||.||||
vekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCs

AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|||||||.||.|  .|.... | .||.| .|  ||..|  .||||.||   ... |..|
aGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_PTPN9_pd Subfamily PTPN9 1367-1623 2.2e-87 287.9 In-house 18-290 (297) alignment
Range on Protein: 1367-1623
Range on HMM: 18-290/297.0
FSQEYESIDP-GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMT
 |.||. |     . | ..|.| .|  ||||..|. ||..|| |...|. . |||||||..|||....|.|||||||..|. |||||||||.. ..||.|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

RLEEKSRVKCDQYWP--ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC------------
|..|. |.|| ||||     ..  | ..|. ....|   |.||.. ....  .|.|..  |||..|||.|||.  . .| .|. |.              
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdew

-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
  ...  |.|||||||.|||| || .|  |.|.... |||.   |  .|.|| ...||..||.| . |.|| |
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1651-1918 6.9e-86 283.1 In-house 21-287 (305) alignment
Range on Protein: 1651-1918
Range on HMM: 21-287/305.0
VTAMELEFKLLASSkaHTSRFISANlPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
 ...| ..|.|..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .  .||||...|   . |
dkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQD
||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||. |.|.||||..|||..   ....| .|.|.... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
 |..||||||||||||||...| |||.. |.|||.|. .|.||..|. |||| |||. .. |  |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

0045098 (Phosphotyrosine protein) phosphatases II 1654-1915 1.2e-85 282.5 In-house 11-273 (278) alignment
Range on Protein: 1654-1915
Range on HMM: 11-273/278.0
MELEFKLLASSKahtSRFISANLPCNKFKNRLVNIMPYELTRVClqpirgvegsDYINASFLDGYrqQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.| ||.|| ..    |..  |....|. ||| ..|.||. .||.          ||||||..|||  .|..||||||| . ..||||||||...|.||||
lefefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivml

TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTIRQFQFTDWPEQGVPKTG--EGFIDFIGQVHKTKE-----
|.| |.|||||.|||| . | .|  |.|  . |.... |.|| ..||.      |..||........ ||. ||| .     |.... ....  .     
telvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

------QFGQDGPITVHCSAGVGRTGVFITLSIVLERMryEGVVDMFQTVKTLRTQRPA-MVQTEDQYQLCYRAALEYLG
      .....||. |||||||||||... . ..||..  ||.||....||.||.|||  .||...||. .|...||.| 
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0042113 (Phosphotyrosine protein) phosphatases II 1674-1914 1.8e-84 278.2 In-house 4-243 (245) alignment
Range on Protein: 1674-1914
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||. |||.|.|. | ..|||||||. ||||. . .|||||||.|..|||||||||...|.|||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.........||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
...|. |.....|| || ||| .|||..||. .|.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPRG_pd Subfamily PTPRG 1652-1916 1.9e-84 278.9 In-house 19-289 (563) alignment
Range on Protein: 1652-1916
Range on HMM: 19-289/563.0
TAMELEFK-LLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGS-DYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. .. ||. |   .....    ... |.|| ||| .||..|. .|| |.|. |.... |||||...|||...||.|||||||.. ..|||||.||.|..|
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQ
|||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ...||...|.||..|||.     . |. .  .....
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

fgQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
  . |||.|||||||||||..| |. .|.... | .|..|...|..|.||. .||||.||.  . | || . |
..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_PTPN9_pd Subfamily PTPN9 1665-1914 7e-84 276.4 In-house 28-290 (297) alignment
Range on Protein: 1665-1914
Range on HMM: 28-290/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC
.. . .|  ..|..|  |||  ... |. ||| |. . . | ||||||.|.|||.|.||.||||||| . ..|||||.||..  .||| |.. |.|| ||
epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkc

HQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFG-----------QDGPIT
 ||||   | ||..  . |  .   .. .|  | ..........||..  |||. ||. |||.... ..|.. .| ... ..            .. || 
gqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||..||..|| | ||| 
vhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1675-1921 1.3e-83 275.1 In-house 5-249 (250) alignment
Range on Protein: 1675-1921
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|.... .|| |.. .| . |||||||||.||...||.||||||| ...||||||..|..|. |||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|..||..|. ||..|||.. .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
. | |||.|. .|.||..|| .|....||  .|...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_PTPN6_pd Subfamily PTPN6 1365-1620 1.8e-83 275.0 In-house 26-294 (306) alignment
Range on Protein: 1365-1620
Range on HMM: 26-294/306.0
LKFSQEYESI---DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTsIDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTA
  |..|.|..   .  .... ....   || |||| |.. .||.||||.  ..||||||||||||..    ....|||||| |..|. |||||||.. . 
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TVVMMTRLEEKSRVKCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC----NP
 .||.|.  |... || .|||.  . |. | |.|| ..  .||.|..|.. . .|. ..|.||..|..| .|||||||. |  .|.||. |..     . 
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE---KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
 .|||.|||||||.|||| |||||..|. ....     .||.  |  .|.||. .||||.|| |...|. 
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1649-1913 1.3e-82 272.7 In-house 31-291 (319) alignment
Range on Protein: 1649-1913
Range on HMM: 31-291/319.0
ESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNST
. .| .| ||. ..   .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .. .|||||.||.|..
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IIVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD
 ||.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | |.|| |  ||..|||. .  .. .. .|.. ...  . 
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE-Y
 .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||...| | || .
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

Y_phosphatase Protein-tyrosine phosphatase 1679-1912 8e-82 269.5 Pfam-A 1-235 (235) alignment
Range on Protein: 1679-1912
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYELTRVCLqpiRGVEG-SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||. ||| |   .| || ||||||....||...|..||||||| .. ||||||.|......|||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|...|...|.||..|||.. ....|.| .|.|.|    ..||..|||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
... |. ||..|.||.||.||| |||...||. .|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1679-1912 8e-82 269.5 In-house 1-235 (235) alignment
Range on Protein: 1679-1912
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYELTRVCLqpiRGVEG-SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||. ||| |   .| || ||||||....||...|..||||||| .. ||||||.|......|||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|...|...|.||..|||.. ....|.| .|.|.|    ..||..|||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
... |. ||..|.||.||.||| |||...||. .|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_PTPRK_pd Subfamily PTPRK 1678-1912 1.9e-81 268.3 In-house 42-275 (314) alignment
Range on Protein: 1678-1912
Range on HMM: 42-275/314.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSArYQ
 |. |||  .|..|. .|| |..| |   ||||||...|.|.. .|.|.||||| | ..||||.....|.. |||||.| | || || .||| . .  |.
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

YFVVDPMAEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRTGVFITLSIVLERMR
 . |  .      ... | |.|. .  |  . |..|||||. ||. .||.  .|..... .|.|..|.  ..|.| |||||| ||||.||...|||. ..
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 |||||.|..|||||.... ||.||.||...| ..||
regvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1650-1911 2.1e-81 268.1 In-house 19-276 (288) alignment
Range on Protein: 1650-1911
Range on HMM: 19-276/288.0
SVTAMELEFKLLASSKAHTSRfISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTI
. | .. |.. ||. . . |    ..|. |. |||  ||.||. .|| |.    ..|.||||||..||....|.|||||||||.. .|||.. .|.... 
nrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDG
|||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ..| |.|.. ||..|||.  . ..... ||. ....    |
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tg

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
||.|||||||||||.||.|  ...... | ..|.. ||. || ||. .|||. ||. .|.. |
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPN12_pd Subfamily PTPN12 1378-1622 4.9e-81 266.8 In-house 28-276 (290) alignment
Range on Protein: 1378-1622
Range on HMM: 28-276/290.0
QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
.... |... |.|. |||| ... ||.||| |. |....||||||||.| |  .. .|||.|||||.|. |||||.||...  |||. |. |  . ||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPARGTETC--GLIQVTLLDTVELA-TYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFI
||| .| |..  | ..||| .   .   ...||......  .|.|...||...||||||||. ....|.... |.  .  .. |.||||||||||||  |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.|| . | .|.||.   .|..  |. .| ||. .|||..||.....|..| 
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Ptp69D_pd Subfamily Ptp69D 1654-1914 6.5e-81 266.8 In-house 24-286 (307) alignment
Range on Protein: 1654-1914
Range on HMM: 24-286/307.0
MELEFKLLASSKAHTSRfISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.. |.. | ... . |    ..   |..|||  .|.... ||| |..| | | ||||||||. ||...| .|| |.|. .  .|||||..| ..|.||||
lakeyekLeareidkst.kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFgqDG
..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| . |...| |..  ||.. .| ...| ||.. ...    .
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rs

PITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||.|||||||||.|.|..|...|.... |  ||.|.||| || ||. .||  .||. .||| |.| 
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

0037934 (Phosphotyrosine protein) phosphatases II 1382-1621 8e-81 266.4 In-house 2-240 (243) alignment
Range on Protein: 1382-1621
Range on HMM: 2-240/243.0
WENSNLEVNKPKNRYANVIAYDHSRVILtsidgvPGSDYINANYIDGYRKqnaYIATQGPLPETMGD----FWRMVWEQRTATVVMMTRLEEKSRVKCDQ
.  ..|..|..|||| ....||||||.|      .||||||||.|.....   .||||||||||  |    ||||.||... ..||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWParGTETCGLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC--------NPLDAGPMVVHCSAGVG
|||  |..|.| ..||||.. .|. |||||. |   . . ..|. .......|||||||. |...|.||. |...        .  . ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERMkhekTVDIYGHVTCMRSQRNY-MVQTEDQYVFIHEALLE
|||..|... ||...    .||..  |  .|.||.. .|||..||.|..|||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1346-1659 1.1e-80 265.8 In-house 2-313 (315) alignment
Range on Protein: 1346-1659
Range on HMM: 2-313/315.0
PIPITDLADNIErlKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|||....   ..  |      ||.|.  .   . .    .  ..| .|||| |.. .|..||.|  ||  | |||||| || .. ...||||.||||. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

MGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE--TCGLIQVTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPTPILA
. ||||||......|.||.| ..|  ..|| |||| | ..    | |.|.||..   .  ..| . . ||   |.| . ||||  |||.||..  . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks..eesrtvtqfqftewPdkGvdkqtssllk

FLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG
... ||| |  .  ...||||||||||| .| || .....|....||..  |. .|..| |.||||..| ||..|.||      | ..  ..  |.| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QVPPGESVTAMELEFK
    |.  . |  ||.
tsvdgsgrskmtkefe

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1656-1913 2.4e-80 265.1 In-house 2-255 (284) alignment
Range on Protein: 1656-1913
Range on HMM: 2-255/284.0
LEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTk
 ||. ..   . ..    |||. || |||...|.... ..| |... |.|.||||||||. ||.... |||||||| .. .|||||.||.|.. ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

lremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHC
     ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |.|||| |  ||..|||. .  .. .. .|.. ...  .  .| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE-Y
|||||||||.|.| ..|.||. |  ||....|. || ||. .||   ||...| | || .
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1365-1663 1.3e-79 262.7 In-house 18-316 (515) alignment
Range on Protein: 1365-1663
Range on HMM: 18-316/515.0
LKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
  ||.|.  .   . .    .. |.| .|||| |.. || .||.|  |.  | |||.|| || ..  ..||||.|||.. .. ||||.|......|..|.
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TRLEEKSRVKCDQYWPARGTET--CGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH
|.|.|  ..|| .||| . ...   | |.| |. .   .  . |.. . |.     | . ||.|  |||.|||.  . .| ... ||| .   . |...|
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih

CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLA
||||||||| .| || .. ..|  ..||..  || .| .| |.|||..|| ||..|.||      | .|   .  |.| |     |.  . |  ||. | 
csaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

S
|
s

subfamily_PTPN6_pd Subfamily PTPN6 1652-1914 3.4e-79 261.0 In-house 26-297 (306) alignment
Range on Protein: 1652-1914
Range on HMM: 26-297/306.0
TAMELEFKLLASS-KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNST
. .| ||. |  . . ..     .. | || |||  ||.|.. ||| |.   .| |||||||.....    ..|.|||||| | .  .|||||.|. ||.
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

IIVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFG-
.|||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|...|..|..||..||||  . ..||. .|.. .|..  
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

-QDGPITVHCSAGVGRTGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 . ||| ||||||.|||| || . |.|. ....|.   .|. ..||..|.||  .||||.||.. |.|  .|.
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1347-1658 6.6e-79 260.4 In-house 5-323 (325) alignment
Range on Protein: 1347-1658
Range on HMM: 5-323/325.0
IPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETM
| . .| ...|. ||.|   |..|.. . . .  . . . .  || |||. ||.|.|.|||.| . .  | ||||||.|.  ..|.. ..|.| ||..|.
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMVWEQRtATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAF
.|.||.| . | ..||...   ..   .| .||| .   . | | ..| |    |.. |  | . . .    | | ..|||...|.| ||...|. ....
ndlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKAC------NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
|. |||       |   ..|..||||||||||| || . ..|... .|  |||.| |  .| .|  ||.| |||..|.||| ||  .| |.||  .. |.
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLGQVPPGESVTAMELEF
.  | .  |      .| ||
lsslqernpltqklniekef

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1388-1622 1.7e-78 258.1 In-house 5-239 (239) alignment
Range on Protein: 1388-1622
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET
 ||| ||||||...||||||.|  .   | ||||||.|.  |    .||||||| .  . ||||||.|..| . .||.| | |  . || ||||   .. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

CGLiQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE
| | .|||  |  .| | .||| . . | .|.| . |..|  |||.|||.| | .| . |..   .   | | |.||||||||||.|.|||||| . |..
cnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
|||||. .| ..| .| .|||| .|||||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1386-1621 4.4e-78 256.7 In-house 4-239 (239) alignment
Range on Protein: 1386-1621
Range on HMM: 4-239/239.0
NLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGT
.  ||| ||||||...||||||.|  .   | ||||||.|.  |    .||||||| .  . ||||||.|..| . .||.| | |  . || ||||   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

ETCGLiQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMK
. | | .|||  |  .| | .||| . . | .|.| . |..|  |||.|||.| | .| . |..   .   | | |.||||||||||.|.|||||| . |
kycnl.rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
..|||||. .| ..| .| .|||| .|||||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN12_pd Subfamily PTPN12 1673-1914 1e-77 255.9 In-house 34-277 (290) alignment
Range on Protein: 1673-1914
Range on HMM: 34-277/290.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE-
... . |. |||  .|.||. .|| |. |...||||||||.|. |  ....|||.||||..  .|||||.||.| .|.||. .. |.|. ||..||| | 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

-RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSI
 .. ... | |. ..| ..  ....| .||.    ..||...||..|.||..|||.. .  ...| .|....|   .| |. |||||||||||. |.. .
eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidy

VLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| | .. | .   .|.|. | .||.||.|.|||..||.| |.| .|..
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1655-1920 3.7e-77 254.0 In-house 23-289 (290) alignment
Range on Protein: 1655-1920
Range on HMM: 23-289/290.0
ELEFKLLASSKAHTSrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM
. .|| | |.. . .    .. . || .||  ||..|.  |. |.|| | .    .||||....||...|.|||||||. .   |||...|....|||||
rnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPIT
||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |..... |.|.| |...|  .  .. .  | .. ||. . | ...| 
ltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
||||..|||..||... . ..... |||.|.|| .|..|.|.| .|||..|||. ..  |.|| ||. |
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_PTPN13_pd Subfamily PTPN13 1383-1622 8e-77 253.2 In-house 30-268 (273) alignment
Range on Protein: 1383-1622
Range on HMM: 30-268/273.0
ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsdYINANYIDGYRKQ--NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP
| .. . || |||| ||. ||..||.| .  |     ||||..|     .    |||.|||||||. |||.|||||..  ..|.|   || .|||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

ARGTETCG---LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPlDAGPMVVHCSAGVGRTGCFIVID
 .  ..      ..|.||....| ...||..|...| |.| ||. ...|..|||||||  ....| |...|.  .  ||||.|||||||.||.| .|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
..|. ....| .|.   | ..| ||. .|||.|||.|...|.||.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

0037934 (Phosphotyrosine protein) phosphatases II 1673-1914 1.9e-76 252.1 In-house 4-242 (243) alignment
Range on Protein: 1673-1914
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYELTRVCLqpirgvEGSDYINASFLDGYRQqkaYIATQGPLAESTED----FWRMLWEHNSTIIVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||.. .....   .||||||| |..||    |||||||...|.|||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQ------FGQDGPITVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|........ ||..||| . | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDMFQTVKTLRTQRPA-MVQTEDQYQLCYRAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||..||. .|.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1673-1914 2.7e-75 248.1 In-house 35-276 (281) alignment
Range on Protein: 1673-1914
Range on HMM: 35-276/281.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER
... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .| ..||.|.||.. ..|||.|.  | |. |||.||| ..
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQdGPITVHCSAGVGRTGVFITLSIVL
 . .|  ..|  .|| . ..|| |.||. ....|..|...|...| ||..|||.| . ...|  .|.|..|.  .  |. .||||||||||..|.|  ..
selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

ERMR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
...   .  .|. ..|. || .|  ||||  ||.  |.| |..|
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1342-1633 8e-75 246.7 In-house 5-294 (297) alignment
Range on Protein: 1342-1633
Range on HMM: 5-294/297.0
RDHPPIPITDLADNIERLKANDglKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKqnAYIATQGP
..  |||..|.|  ... .  |   ||.|.  .   . ..   ..  || .|.||.|.. || |||.| ...  | |||.|| .. |...   .|.|| |
kerrpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPE--YPT
 ..|. |||.||......|.||.. ..|. . || .||. .|. | | . |.|| . |   .  |.. . |. .  .| ..|.||. |||. |..    .
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

PILAFLRRVKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPAR
 .| ..  |.      |  |..|||.||||||| .. || .. ..|.||.|||.| |. .| .| |.|||..|| |...|.|||  . .|...| 
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1380-1621 4.7e-74 243.9 In-house 18-266 (274) alignment
Range on Protein: 1380-1621
Range on HMM: 18-266/274.0
FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG-SDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
|. |. ..  .. |||| ...  ..|||.|.| ..    |.||||||| ||.. ..||.|||||||.|. |||||......  .||.|.|.|. . || .
fdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPARG----TETCGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACN---PLDAGPMVVHCSAGVGRT
|.| .     .|. | ....  ..||   |.||.. |... .  .|..  . . .|||| .|. ....| ... |.  .      ..|.|||||||.|||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
|||| |.  . ....|..||. . |. .| .|  ||||..|| .||.|| .
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1347-1625 9.4e-74 242.9 In-house 2-285 (290) alignment
Range on Protein: 1347-1625
Range on HMM: 2-285/290.0
IPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG--SDYINANYIDGYRKQNAYIATQGPLP
||. .... ..  .|.   .| ......| |. ..| .  . . ||..||.||.. ||  |..|  | | .    .|||| ||.||.....|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHG-VPEYPTPI
.|. |||...|..... .||.|   |. .||| ||||...|.. | ....||.  .| .|. |.. .... |  .|... |.|. .|...| |... | .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
|.. ...|       ...|||||..|||.. |....  ....| |  .|..  .  .|.|.  .|||..|| .|.. .|.. ..
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN3_pd Subfamily PTPN3 1381-1623 2.1e-73 241.7 In-house 32-275 (280) alignment
Range on Protein: 1381-1623
Range on HMM: 32-275/280.0
TWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYID----GYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
. .....  | .|||| ....||. ||.|.. .     |||||||..    .    | ||||||||..|. |||.|||||.. ..||.| | |. |||| 
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPARGT-ETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
||||  .   . | ..|..  . |  .| .| . |... ..|.|.. |.|..||||||||. .. .| |..||...   .  |.|||||||.|||| .|.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
..  |  . ... | .   |  || ||  .|||..|| |. ||.|.. 
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1351-1630 4e-73 241.3 In-house 6-286 (439) alignment
Range on Protein: 1351-1630
Range on HMM: 6-286/439.0
DLADNIERLKANDGLKFSQEYESIDP---GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMG
.. . .|.|. |.   |....|.|.      .        | ...|||| .| |.||.||.|  | ||| | |||||||.|| ... |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQRTATVVMMTRLEEKSRvkcdqYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQFMAWPDHGVPEYPTPILAFL
||||.|.|..|.|.||.| | |  .     |||. .    | | |     .||  |..| | . .    .  .| . ||...||||. ||   . .| ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKACNP-LDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||| | |. .| ||. |||.  |||||..|.||    | . |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1678-1914 3.3e-71 235.0 In-house 42-276 (515) alignment
Range on Protein: 1678-1914
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||. .|| |. |     |||.|||.. ..  .|||||.|||.  |..||||.....| | |.|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||. ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   .||.|..|. .| .|| .|||..|| . | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1390-1621 4.4e-71 233.9 In-house 3-237 (237) alignment
Range on Protein: 1390-1621
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVILTSIDGVpgSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARG-TETC
|| ||||.|..|||||||.|    .   ||||||.|..|.    . |||.||||  .  |||.|||... . .||.| | |. ..|| .|||     .. 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GLIQVTLLDTVELATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGRTGCFIVIDAMLERMK
| . |.|    |.. ||||.. | | ..  | | . |.|| .|||.|||.. . .| | ...   .|   ..|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .| |||| .| ..  .| |..||.|||||||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1658-1921 7.8e-71 233.4 In-house 26-285 (287) alignment
Range on Protein: 1658-1921
Range on HMM: 26-285/287.0
FKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR
|..| . . .      .  . || |||| .|....  || |.     |  |||||.|.|||...||.|....|...   .||......| |.||||....
ftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSA
|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ....|.|.|.|...|  .. .  .  | .  ||. . | ...| ||||.
endeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsivvhCsd

GVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA
.|||...|.   . ... . |||.|.|| .|  | |.| .||| .||.  . . |||| ||. |.
tvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1675-1915 3e-70 231.5 In-house 24-269 (274) alignment
Range on Protein: 1675-1915
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-SDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .. ||.. .|||.||||||..  .|||||........|||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|..  . .||||.. .|.  . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
|| . ..| |.|||....|  || .|  ||||..||.| .||  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_PTPN3_pd Subfamily PTPN3 1667-1907 3.4e-70 231.2 In-house 29-268 (280) alignment
Range on Protein: 1667-1907
Range on HMM: 29-268/280.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpirGVEGsDYINASFLD----GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE
       |..| |  |||  .|.||. ||| |.     |  |||||....    .  . . |||||||||....|||.|.||..|..||||| | | || 
pglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv

KCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRT
||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.| |.|...||..|||.  . |..|. .|.|...  |.. |. ||||||.|||
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvvvhCsaGigrt

GVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
||.|.| . |  .  .  | . . |.|.| || ..|||..||..  
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC

subfamily_PTPN1_pd Subfamily PTPN1 1377-1628 1.8e-69 228.7 In-house 19-276 (290) alignment
Range on Protein: 1377-1628
Range on HMM: 19-276/290.0
GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
 ..|. ....|. |...||| .|  |||||..| . |     |||||. ..  . .  || ||||||.|.. ||.|||||.. .|||. .. ||...|| 
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPARGTETCG-----LIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL--DAGPMVVHCSAGVGR
||||    | .       ..|.|. . .  .||||.. |..  . | ||. .| ...||| |||| |.  | || .|. .  |  | || |.|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGCFIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHT
.| |...|..| ......    |||  ..  .|..|  ..|| ||  | . |.|| | . ..
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1388-1630 9.3e-69 226.6 In-house 45-285 (287) alignment
Range on Protein: 1388-1630
Range on HMM: 45-285/287.0
EVNKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETC
. ||.|||..... .|  ||.|         ||||| .||||....|.|....|. .|. .||.......  ..||.....|. . .| ||||   . . 
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

GLIQVTLLDTVELATYTVRTFALHKSG-SSEKRELRQFQFMAWPDHG-VPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH
|  ...||.    | |..|.. ..... ...|....|.|. .|...| |.|. | .| . ...|.      ...|||||..|||.. |. ..  ... | 
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt

EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
| ..|..  .  .| |.  .||| .|| || ...||  ....| .
eGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1669-1914 1.6e-68 225.9 In-house 34-277 (315) alignment
Range on Protein: 1669-1914
Range on HMM: 34-277/315.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW
.|  .|  . |  |||  ||.|.. .|| |. |     |||||||.. .. ..|||||.||||  | .|||||..... | |||.||..|  . || |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRTGVFIT
|     |...  . |. .      . . |.. ||  .  .|||. |||||.||..||.|    .. .| .|   ...  .. .. ||||||||||||.|.
PdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.  |..... . .||.|..||.||..|| .||||..| . | | ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1656-1915 3e-68 225.3 In-house 27-289 (325) alignment
Range on Protein: 1656-1915
Range on HMM: 27-289/325.0
LEFKLLASSKAHTsrFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
 ||.|| |  . .  .  | .| || |||. |..... .||.|.  .    |||||||.|  ..... ..|.| ||.....|.||.. . .....|.| .
hefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

LrEMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ----DGP
| . | ..| .||| |   | ..  . |  ..  ..  |. | ..| ....|..|...|||.  |.. ||.|    .| ..  |.. .|.        .|
l.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

ITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG
| ||||||||||||||.|  .|...  |  ||.|. || || .||.||.| ||| |.| |  |.. 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1667-1918 3.9e-67 221.5 In-house 39-288 (297) alignment
Range on Protein: 1667-1918
Range on HMM: 39-288/297.0
HTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQqkAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGReKCHQ
 .     |.   |  |.|  ||.||.  || |. .     |||.||||. |...   .|.|| |  .. .|||.|..... ..||||... |  . || .
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPK--TGEGFIDFIGQVHKTKEQFGQDgPITVHCSAGVGRTGVF
||. . .. . . .|  ..  .   .| ||..||  .  . | ..|.||..||.. |..  . . ....| .|.|. .|  .  |. |||.||||||||.
yWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvl

ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFD
.|.  |. ... |  ||.|..|| || .|| .|||..||.. | | ||.| | |
ltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_PTPN13_pd Subfamily PTPN13 1657-1916 1.3e-66 219.7 In-house 16-271 (273) alignment
Range on Protein: 1657-1916
Range on HMM: 16-271/273.0
EFKLLASSKAHTSRFiSANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSdYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLT
||| |   |.  .   ...   || |||  |..||. ||| |.     ||. |||||..      ..  |||.|||| |...|||.|.|| ....|.|.|
efkelrelkpldtce.vgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPIT
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| . ...|..||. |||.. . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|..|| || ..|||.||| ..|.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1679-1914 1.8e-66 218.9 In-house 20-264 (270) alignment
Range on Protein: 1679-1914
Range on HMM: 20-264/270.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQ-QKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--R
.|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. ....||||.||...| |||.|.| | ||.|| .|||||.    .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

YQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTIRQFQFTDWPEQGVPKTGE------GFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL
...    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . .|. |||||||||||..|.|
ledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 |... .  .. ||. . .. || .|.|.||. .||.. |.| .|| 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1387-1638 3.3e-66 218.0 In-house 30-281 (283) alignment
Range on Protein: 1387-1638
Range on HMM: 30-281/283.0
LEVNKPKNRYANVIAYDHSRVILTSIDGvpgsDYINANYID---GYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARG
 . ||.|||. .....|  || | |       ||||| .|     |.... ||..|.|| .|. |||.||.... ...||.|.| |  |.|| |||| ||
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE-LRQFQFMAWPDHGvPEYPTPILAFLRRVKAC-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLE
.|  |   ||| . .   ..... . |....|...   |  .|.  | . | .. .   |  . .|..  .    ||.|||||.|.|||. || . | ..
sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH
 .. |  ||..  |. || ||  .||| ||| ..||. || | || |.. | .|.. 
daltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1346-1667 1.7e-65 216.0 In-house 3-280 (392) alignment
Range on Protein: 1346-1667
Range on HMM: 3-280/392.0
PIPITDLADNIERLKanDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPET
|||....   .|. .      |..|.  .   . .    .. |.|..|||| |.. || .||.|  || .| |||.|| ||...  ..||||.||| . .
pipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MGDFWRMVWEQRTATVVMMTRLEEKSrvkcdqywpargtetcgliqvtlldtvelatytvrtfalhksGSSEKRELRQFQFMAWPDHGVPEYPTPILAFL
. ||||||......|..|.|.|.|                                               ..|   ||.|  |||..||.. . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQV
. |||     . |...||||||||||  | ||... . |. . ||..  || .| .| |||||..|| ||. |.||      | .|   .  |.|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

PPGESVTAMELEFKLLASSKAH
  |.  . .  ||. | .|.. 
sdGdvrskqlkefrslkashtv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1677-1914 5.1e-65 214.5 In-house 47-279 (315) alignment
Range on Protein: 1677-1914
Range on HMM: 47-279/315.0
PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAErSARY
  || ||| .||..|. .|| |  .   ..|||.||.|.||| ... |||.|||...| .||||...|.. . |||||.| |  ..|. .||| .    |
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviy

QYFVVDPMAEYNMPQYILREFKVTDarDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |  . |    .|  | . |.   . . |.. |...| ||. ||||    ....| .|.. ...    |.| ||||||||||| ||||. ||...  
Gkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaea

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
| ..|... .. .| .|  |||. .|||. | | || .
enaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_PTPN23_pd Subfamily PTPN23 1650-1913 1.1e-64 213.0 In-house 13-279 (288) alignment
Range on Protein: 1650-1913
Range on HMM: 13-279/288.0
SVTAMELEFKLLASSKAHTSRFISAN-LPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQ-KAYIATQGPLAESTEDFWRMLWEHNS
 .||.. .||.| ..... .|  |     ..  |||  .|.||. .||.|.     .  |||||||. .   .   .||||.||...  |||.|..|  |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHK--TKEQ
 .||||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ....  |.| ||| |||.. | ...|...|..  ...|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

FGQDGPITVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
   . |. |||||||||||||    ..| |  . .|..|. | |..||.||  |||...|.. .| | ||.
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1390-1622 1.4e-64 212.7 In-house 20-263 (270) alignment
Range on Protein: 1390-1622
Range on HMM: 20-263/270.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQ-NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE---
.|  ||||...   ..||.| ...  . . ||||||. |. .. ..|||..|||| |. .||||.||... ..||.| |||| | ||..||||.  |   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-TCGLIQVTLLDTVELATYTVRTFALHKSGSseKRELRQFQFMAWPDHGVPEYPT------PILAFLRRV-KACNPLDA-GPMVVHCSAGVGRTGCFIVI
 . | |.|. | ..    | ..   |...|.  .|.|  |.. .|||||||. .        .|. || | . .. ||  .|..|||||||||||..|..
ledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
| ... ....| ||.   .. .| .|  .||. .|| |...|..| 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_PTPN14_pd Subfamily PTPN14 1657-1914 5.8e-64 211.0 In-house 28-296 (300) alignment
Range on Protein: 1657-1914
Range on HMM: 28-296/300.0
EFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVeGSDYINASFLDGY--RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLT
|.  ..  ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| .      ... ||..||||    .|||.|.||.. ..|||||
eyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQ----
. .| |.||...|.| .    ...... | |      . ...| . .|.     .. ||.  .|.||||..|||.  .||.... .|.  .... .    
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   . |. |||||||||||| |.  .... .  . ..|. .....||.||  .|||  ||.  |.. ..||
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_PTPRN_pd Subfamily PTPRN 1380-1621 1.3e-63 209.5 In-house 46-290 (297) alignment
Range on Protein: 1380-1621
Range on HMM: 46-290/297.0
FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYI-DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQY
 | | .. | |  |||...|..|||||| |..      ||||||  | |   .. |||||||||..|. |||.||||| .. .|..|||||..  .|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPARGTETCGLIQVTLLD-TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID
||  |.|. .. .| |.   .    | ||.| |    .|| | . || |..||..|||  . ..| | |.|  .    . |.|||||.|.||||..|.||
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

AMLERMK-HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 .|.|..   | .||   .  .| ||. .|.|.||. |.  |. |
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_CG7180_pd Subfamily CG7180 1679-1914 1.8e-63 208.9 In-house 42-290 (296) alignment
Range on Protein: 1679-1914
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||.. |.. ..|.|| |..|  |. ..|||.......  .|.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF---GQDGPITVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |....||.| |.  . ||   ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
... . || .. |. ||.|. ||||| .|| .|.. ..|. .|   ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1377-1620 3.7e-62 204.7 In-house 25-274 (287) alignment
Range on Protein: 1377-1620
Range on HMM: 25-274/287.0
GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILtSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCD
.  .|. ...   .  |||||.|. .|..||.| | .|  |||||||||. .|....|.||.|||.. |..||||.|.|.|.|.|..|||  |..| || 
sstatfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPARGTE-TCGLIQVTLLDTVEL-ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV-----KACNPLDAGPMVVHCSAGVGR
.||| |      |   |.|||   .   |.||.. | .  . | | ..|.....|||....     .. |   |      | .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
.| .. . ....|..    ||.   |  .| .|. .||.  |. .. ||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_CG7180_pd Subfamily CG7180 1390-1627 8.1e-62 203.5 In-house 42-294 (296) alignment
Range on Protein: 1390-1627
Range on HMM: 42-294/296.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWPARGTETCGL
|. |||. .|. ||. ||.|...||   |||||| |.|.. |...|| |..|  ||...|||.|... . .||..|.  . .. .. .||| .. |  | 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

IQVTLLDTVELATYTVRTFALHKS----------GSSEKRELRQFQFMAWPD-HGVPEYPTPILAFLRRVKACNP-L----DAGPMVVHCSAGVGRTGCF
| | .. . ..|  . ||| | |            . |.| ...||.  |.  . ||   . .. ..|||.          . ||.||..| |..|.| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

IVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGH
. ||| || ...|. ||... |  .| .|. .|.. ..| .| . ||||  |. 
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1677-1920 8.9e-61 200.2 In-house 38-299 (301) alignment
Range on Protein: 1677-1920
Range on HMM: 38-299/301.0
PCNKFKNRLVNIMPYELTRVCLQPIRG--VEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA
  ||  ||  || .|.  |. |.| .   .   .|||||..|||...|..||.|||. .   ||||..|..  . |||.|.|.|  ..||.||||  .  
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

RY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAG
..    | |  . |...|....|...|.  |              .| .|... |.| ||||..|| .     .  | .| ... . |  ||. ||||..
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSdt

VGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
|.|.||....|| ||  . |||||.|| .|..| ..| .|.| .||   | .  .||   . |
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_PTPN23_pd Subfamily PTPN23 1388-1623 1.9e-60 199.2 In-house 41-280 (288) alignment
Range on Protein: 1388-1623
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQ-NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET
...  |||. ... |||.|| |         ||||| .. .   .   .||||.||..|..|||.||.||.. ..||..  ||. . |.|.|||..  ||
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

--CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD----AGPMVVHCSAGVGRTGCFIVIDAM-
   | ..||| .. |. |.  |.. |.  .........  |...||..|||. |  .|.||  |...          |.|||||||||||| | .. |  
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
 |  |..  .||   |  .| || .|||...|. |  || ||||
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPN14_pd Subfamily PTPN14 1368-1620 2e-60 199.4 In-house 26-293 (300) alignment
Range on Protein: 1368-1620
Range on HMM: 26-293/300.0
SQEYESIDPGQQ-FTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVpGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
 .||| | . ..  . . ..|..|..|||. .|. |...|| |..      ..||||  |      |.  ||..||||. |. |||.||||| .. .||.
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TRLEEKSRVKCDQYWPARG----TETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACN-----PL-
|. ||. . |. .|.|  .    | . |  .||   . .  ... ... |.   |.|.|..  .|.. |||||||| ... | .|..|..          
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

---DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
      |..|||||||||||  |. | ... ..|....||   .. .| || ..|||  || |....|.
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

subfamily_PTPRN_pd Subfamily PTPRN 1654-1912 2.9e-60 198.5 In-house 31-290 (297) alignment
Range on Protein: 1654-1912
Range on HMM: 31-290/297.0
MELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFL-DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVM
.| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.. |   .. ||||||||||..  |||.|.||. ...||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPIT
||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||. || |  |||.||| .   ...|  .| |.    |.  || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCSAGVGRTGVFITLSIVLERMRyEG--VVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
||||.|.|||||.| . .||.|.   |   .|.  |.. || ||| .|.|.||..... |  |
vhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1678-1913 8.4e-60 197.0 In-house 32-265 (283) alignment
Range on Protein: 1678-1913
Range on HMM: 32-265/283.0
CNKFKNRLVNIMPYELTRVCLQPIRGvegsDYINASFLD---GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA
 || |||  .|.|..  || |..       |||||.|.     |.|.| ||..|.|| .   |||.|..... | |||||||.|  |.|| |||| . | 
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSR-TIRQFQFTDWPEQGVPKTGEGFIDFiGQVhKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
 |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..|  .. 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasasvkd

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
.. | |||.|..|| .| ||. .||| |||.| . ..|| 
altesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1679-1914 1.5e-59 196.6 In-house 48-279 (439) alignment
Range on Protein: 1679-1914
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| ...|| ..| |||||||  |.|.||||...|.... |||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||. ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
|  ||.   || || ||  |||.  || . | | || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1660-1913 3.4e-59 195.0 In-house 19-276 (287) alignment
Range on Protein: 1660-1913
Range on HMM: 19-276/287.0
LLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREM
|   |.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| .  ||||...|..|. ....|.  | 
lkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtrevee

GREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV--HK-TKEQFGQDGPITVHC
.| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| ..|... .||..... |  |.| |. .|  |   . .  . ||. ||.
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
..|.||.|..... ....|.   | ||. ..|  || .| |.||.  |..| | |   |
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

0051429 (Phosphotyrosine protein) phosphatases II 1415-1642 4.4e-58 192.3 In-house 1-243 (272) alignment
Range on Protein: 1415-1642
Range on HMM: 1-243/272.0
VPGSDYINANYIDGYRK---QNAYIATQGPLPETMGDFWRMvWEQRTATVVMMTRLEEKSRVKCDQYWP------------ARGTETCGLIQVTLLDTVE
.| |.||||....|| .    .......|||| |  ||||. .|..  |.|.....||. |.|||.|||            .  | . | . |||| .. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LATYTVRTFALHKS-GSSEKRELRQFQFMAWPDHGVPEYPtpILAFLRRVKAcnpldAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVD--------
|  |..|.. |..  . .| ||........|||||||. .  .|..|. . .      ||..||||||..|||...... .|... .|  ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAaTCGHTEVPARNLYAHIQKL
... |  .|.|| ..||||.||.|..|||||.  .....|.|. | |... .
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1363-1625 3e-57 188.6 In-house 13-295 (301) alignment
Range on Protein: 1363-1625
Range on HMM: 13-295/301.0
DGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG--VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT
   ||...|.... |.. . . .  | ||. ||. |.  ||. |.||.      .   .||||.|||||......||.|||. .|. ||||..|......
hsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

VVMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL---------------HKSGSSEKRELRQFQFMAWPDHGV-PEYPTPIL
.||.| |.|... || ||||     .|. | ..||| ..  .  ...| ...               ... . . ... |.|   ||..|| .|. | . 
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

AFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATC
.    ... .  . ||.|||||..|.|.| .. ..  ||  | |  ||... .  .| ..  .|.| .||..|.... .  ..
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1679-1912 5.1e-57 187.8 In-house 3-237 (237) alignment
Range on Protein: 1679-1912
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYELTRVCLQPIRGveGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||..|.|.    | |||.||||  | .|||.|.|. . ..||||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | | |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 . |||... |...  .|| ..||.||| . ... ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN1_pd Subfamily PTPN1 1666-1912 2.3e-56 185.6 In-house 19-269 (290) alignment
Range on Protein: 1666-1912
Range on HMM: 19-269/290.0
AHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGvegsDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH
|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||.. .. ||.|.||..|  .||| |. | .. ||.
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGR
|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.| .| .| ||. |||..   |..|. .| ..     . ||  .|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGVFITLSIVLERMRYEGV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.| |. .  .| ..  ..    ||. ...  || .|  ..|| || .. | | ||
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

0051429 (Phosphotyrosine protein) phosphatases II 1705-1916 2.7e-56 186.5 In-house 2-227 (272) alignment
Range on Protein: 1705-1916
Range on HMM: 2-227/272.0
EGSDYINASFLDGYRQ---QKAYIATQGPLAESTEDFWRMlWEHNSTIIVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  . .||||. .|.. . ||.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTIRQFQFTDWPEQGVPKTGegFIDFIGQVHKtkeqfgqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.......||||  |||.    ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
 ....|. || |||..||||.||. .|.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1678-1912 9.4e-56 183.6 In-house 6-238 (239) alignment
Range on Protein: 1678-1912
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||.|  |    |||||||| .. |. |||||.|.    .||||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.  ||.|. ||..| .|| |||| .|| . . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1678-1912 1.2e-55 183.2 In-house 7-239 (239) alignment
Range on Protein: 1678-1912
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYR-QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||.|  |    |||||||| .. |. |||||.|.    .||||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | . |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
.  ||.|. ||..| .|| |||| .|| . . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1673-1914 2.1e-55 182.7 In-house 39-236 (392) alignment
Range on Protein: 1673-1914
Range on HMM: 39-236/392.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGrekchqywpaer
.|. . |. |||  ||.||. .|| |. |  .  |||.|||..... ..|||||.||| | | .|||||....| | |.|.|||.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

saryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhktKEQFGQDG-PITVHCSAGVGRTGVFITLSIVL
                              .  . ||. ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |.
..............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsvv

ERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 . .   .||.|. |  .| .|| ||||..|| . | | || |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

0041856 (Phosphotyrosine protein) phosphatases II 1390-1630 3.7e-55 181.6 In-house 1-178 (182) alignment
Range on Protein: 1390-1630
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRviltsidgvpGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTrleeksrvkCDQYWPargtetcgl
|..|||| ... |||||          ..||||||...|..... .|||||||..|. ||.||..|..  |.|..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iqvtlldtvelatytvrtfalhksgSSEKRELRQFQFMAWPDHGVPEyPTPILAFLRRVKAcnplDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhekTV
                         . ..|.  |.... |||||||. .  .|.|...|..    . || .|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV
...  |  .||.|. ||.|..||.|.. ||||   .. |..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp

0036282 (Phosphotyrosine protein) phosphatases II 1417-1617 2.4e-52 172.4 In-house 1-164 (174) alignment
Range on Protein: 1417-1617
Range on HMM: 1-164/174.0
GSDYINANYIDGYRKQNAYIATQGPLPetmgdFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPArgtetcgliqvtlldtvelatytvrtfalhkSGSS
|||||||...|...  . .||.||||.     ||.|..|..  ||||.....|. ..|| .|||                                  ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKRELRQFQFMAWPDHGVPEYPTpILAFLRRVKACNPL-DAGPMVVHCSAGVGRTGCFIVIDAMLERMKhEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
..|.  |.... |||||||. .. .| |...|. .    . ||..|||||||||||...... || ... |..||.. .|  .|.|| .||||..|| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HE
..
yy

0036282 (Phosphotyrosine protein) phosphatases II 1706-1908 2.6e-52 172.3 In-house 1-164 (174) alignment
Range on Protein: 1706-1908
Range on HMM: 1-164/174.0
GSDYINASFLDGYRQQKAYIATQGPLAestedFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||.||...  . .||.|||||     ||.||.|...|..|||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTIRQFQFTDWPEQGVPKTGEgFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERMRyEGVVDMFQTVKTLRTQRPAMVQTEDQYQL
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..|| ...|..||.||| ||||..||. 
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYR
.| 
lyy

0041856 (Phosphotyrosine protein) phosphatases II 1679-1914 5.4e-52 171.3 In-house 1-171 (182) alignment
Range on Protein: 1679-1914
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYELTRvclqpirgveGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| ....||.|||.|.. |.||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTIRQFQFTDWPEQGVPKtGEGFIDFIGQVHKtkeqfgQDGPITVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
 |.....||..| .|| ||.|..||.....|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1376-1622 3e-49 162.2 In-house 42-282 (290) alignment
Range on Protein: 1376-1622
Range on HMM: 42-282/290.0
PGQQFtwENSNLEVNK--PKNRYANVIAYDHSRVILTsiDGVPGsDYINANYIDGYRkqNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRV
|.|..  | . .. |    |||| .|.  | .||||   || .| ||. |||..| .    .| |||.| .|. |.|||| ....|..||.  | |. . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPARGTETCGLIQVTLLD---TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRT
||.||.| .  |.  . ..|.|    . . |    .|... .  |  .  |. .. ..|||. |.     .|  || ..      .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
| |. |.. |. . . | .|. . |  .|  |   || . ||. . |.||. 
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

0043147 (Phosphotyrosine protein) phosphatases II 1416-1617 1.6e-47 156.8 In-house 3-155 (172) alignment
Range on Protein: 1416-1617
Range on HMM: 3-155/172.0
PGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLeeksrvkcdqywpargtetcgliqvtlldtvelatytvrtfalHKSGS
.|||||||.|.|.|.. . .|||||||..|. |||||..|.   ..|..|.|                                            . ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SEKRELRQFQFMAWPDHGVPeYPTPILAFLRRVKA-CNPLDAGPMVVHCSAGVGRTGCFIVIDAMLermkheKTVDIYGHVTCMRSQRNYMVQTEDQYVF
 ..|.  |.... |||||||  .  .| ||. ..  ..  . ||..|||||||||||...... ||      . ....  |  .|..|...||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IHE
...
lyy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1386-1623 5.2e-47 155.3 In-house 37-277 (307) alignment
Range on Protein: 1386-1623
Range on HMM: 37-277/307.0
NLEVNKPKNRYANVIAYDHSRVILTsIDGVpGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE
 .. |  |||| .| . |..|.... .||.  |||| |||.    | . .|..|||| .|. .|| |. ...  .|.|. .. | ...||.||||.   .
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

T------CGLIQVTLLDTVELAT--YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFlrrVKACNpLDAGPMVVHCSAGVGRTGCFIVID
.         | |. | . .||     .   .|.   ... | ....|.  |||.|||.     . .   ..| .  |  |.||||||||||.|  . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl...leavr.ydtnpvvvhcsaGvGrsGtivais

AMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
 . ..| . .   |.   |  .||||.| .||| ||...|  |||  
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0049772 (Phosphotyrosine protein) phosphatases II 1662-1914 7.5e-47 155.9 In-house 29-280 (314) alignment
Range on Protein: 1662-1914
Range on HMM: 29-280/314.0
ASSKAHTSRFISANLPCNKFKNRLVNIMPYElTRVCLqPIRGVEGSDYINASFLDGYrqqKAYIATQGPLAESTEDF----------WRML--WEHNSTI
  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .  .||          |||   ...|. .
slsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTIRQFQFTDWPEQGVPkTGE
|||                     |..| . |      ...|.. . ..                    .... ..  .|.. ..  ...|  ..| . |
ivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvpDgsap.lle

GFIDFIGQVHKTkeqfGQDGPITVHCSAGVGRTGVFITLSIVLERMryeGVvDMFQTVKTLRTQRP-----AMVQTEDQYQLCYRAALEYL
 | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. .... .| .||      .... .||. ...| ||||
dfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1384-1623 1.7e-46 153.4 In-house 27-259 (267) alignment
Range on Protein: 1384-1623
Range on HMM: 27-259/267.0
NSNLEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvKCDQYWPARG
 |  | |. .||. ... ||..||||   .     .|||| |..||...||.|.||.||  |..||. .. .|. ...|..|.  .    .  ..|| . 
qsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkm

TETCGLIQVTLLDTVE--LATYTVRTFALHKSGSSEkRELRQFQFMAWPdhgVPEYPTPILAFLRRVKACNPLDAG--PMVVHCSAGVGRTGCFIVIDAM
 ..    ..|.  ..|     | . |. |.    |  ...  . .  |    .     | |  |  . | | |. |  |.||.||.||||.| |.|||..
gqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsq

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAA
|||.|.| ..||.  .  .||||  .|.| ..|..||| | | |
leraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

0046846 (Phosphotyrosine protein) phosphatases II 1412-1620 1.8e-46 153.4 In-house 6-170 (176) alignment
Range on Protein: 1412-1620
Range on HMM: 6-170/176.0
IDGVPGSDYINANYIDGYRkqnaYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCgliqvtlldtvelatytvrtfalh
.   ...||||||.|.|.|    .||||||||.|. ||..|..|..  .||..| . |..|.||..|||   .. .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

ksgssekrelrQFQFMAWPDHGVPEYpTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDamleRMKHEKTVDIYGHVTCMRSQRN-YMVQTED
           |.... |||||||.. . .| .|. .. .   . || .||||||.||||......     ...|| ....  .  .|.||  ..|||..
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYVFIHEALL
|| |..|..|
Qyrflyefel

subfamily_ptpA1_pd Subfamily ptpA1 1385-1585 2.7e-46 153.2 In-house 42-258 (418) alignment
Range on Protein: 1385-1585
Range on HMM: 42-258/418.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGY-RKQnaYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA--
 . . |  ||||.|..  .|.|| |  |.   ||||||||||||   ||  .|.||||||.|. ||||||||.|   .||..|  |. |.|||.|||   
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

---------RGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC----NPL--DAGPMVVHCSAG
          | |  |   | |.. ..     . |  .. .   | |.. |.|.  |||| .|..  |.  .|. .        |      |..||||||
ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGCFIVIDAMLERMKH
||||| |     |.... |
vgrtgtfctavimmkkldh

0043147 (Phosphotyrosine protein) phosphatases II 1705-1907 5.7e-46 151.7 In-house 3-154 (172) alignment
Range on Protein: 1705-1907
Range on HMM: 3-154/172.0
EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||.||.|.  . .||||||| . ..||||||.|.. |.||.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTIRQFQFTDWPEQGVPkTGEGFIDFIGQVHKTKeQFGQDGPITVHCSAGVGRTGVFITLSIVLERMryegvvDMFQTVKTLRTQRPAMVQTEDQYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

LCY
..|
fly

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1665-1912 2e-45 149.9 In-house 19-293 (297) alignment
Range on Protein: 1665-1912
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQpiRGVEGSDYINASFLDG--YRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE
.|..  | ||. .    |||  .|. .. ||| |.  |.. ..||||| ..      ..  || .|||| .. .|||....|..  .|||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTIRQFQFTDWPEQGVPKTGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| .|  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   .. || ||. .||| .|..|.| |.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

0046846 (Phosphotyrosine protein) phosphatases II 1698-1915 2.1e-45 150.0 In-house 3-174 (176) alignment
Range on Protein: 1698-1915
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFLDGYRqqkaYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||....|.|    .||||||| ....||..||.|.. |..|.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtirQFQFTDWPEQGVPKTgEGFIDFIGQVHKTKEQfgqDGPITVHCSAGVGRTGVFITLSivleRMRYEGVVDMFQTVKTLRTQRP-AM
              |.....||. |||   | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDQYQLCYRAALEYLG
|||..||. .|...|..|.
vqtpeQyrflyefellllk

0049772 (Phosphotyrosine protein) phosphatases II 1380-1624 2.4e-44 147.7 In-house 36-281 (314) alignment
Range on Protein: 1380-1624
Range on HMM: 36-281/314.0
FTWENSNLEVNKPKNRYANVIAYDhSRVILtSIDGVPGSDYINANYIDGYrkqNAYIATQGPLPETMGDF----------WRMV--WEQRTATVVM----
.|.  ..|..|. |||| ... .| .|||| .  .| |||||||.|.||.   ...|||||||..|. ||          ||||  ..... ..||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTRLEEKSrvkcDQYWPARGTETCgliqvtlldtvelatytvrtfalHKS--GSSEKRELRQFQFMAWPDHGVPeYPTPILAF
                  ..| ..     .....|.  . .                            ..  .|.  ..  . .||...|  .  ...|
vladelsrLdaAlgKtpllildgng....neptaadlellk.......................eelydpelferlgikylripvpDgsap.lledfdef

LRRVKACnpLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHeKTVDIYGHVTCMRSqRN---YMVQTEDQYVFIHEALLEAAT
|. ....   . || .|||.||.||||.|.|.. .. ...     ... .|  .|.  |    .... .||.||.|||||.  
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylk

0049260 (Phosphotyrosine protein) phosphatases II 1425-1617 3.1e-44 145.6 In-house 1-144 (152) alignment
Range on Protein: 1425-1617
Range on HMM: 1-144/152.0
YIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWpargtetcgliqvtlldtvelatytvrtfalhksgssekrelrQF
.||||......||||||.|.|. |||||..|.   |.||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLermkheKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
... |||||||. .  .| .|. .. ..  . || .|||||||||||...... ||      . |...  |  .|..|...|....|. |..|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1651-1914 2.1e-43 143.5 In-house 15-277 (307) alignment
Range on Protein: 1651-1914
Range on HMM: 15-277/307.0
VTAMELEFKLLASSKAHTsrFISANLPCNKFKNRLVNIMPYELTRVCLQpIRGVeGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
|.|.  ||. ||  . ..       . .|  |||  ..   . .|. .. . |.  |||| | .|    . | .|..|||| ..  .|| |  ...   .
vqalvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHktke
.|| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..||||...|...||..|||..  . |...  |.    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

qfGQDGPITVHCSAGVGRTGVFITLSIVLERM-RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  ..  |. |||||||||.|  ...|.| ..| . .   || . |. ||.||.  .||| ||   .|  |||.
..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0049260 (Phosphotyrosine protein) phosphatases II 1714-1907 2.4e-42 139.5 In-house 1-143 (152) alignment
Range on Protein: 1714-1907
Range on HMM: 1-143/152.0
FLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtirQF
|.|||......||||||. ....||||||.|.. |.|||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKTGEGFIDFIGQVHKTkeQFGQDGPITVHCSAGVGRTGVFITLSIVLermryeGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
... ||  |||.  . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|. .|..|| .|....|....|
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1653-1913 1.1e-41 137.6 In-house 7-258 (267) alignment
Range on Protein: 1653-1913
Range on HMM: 7-258/267.0
AMELEFKLLASSKAHTSRfISANLP-CNKFKNRLVNIMPYELTRVCLQpirGVEgSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
 .| ||.|.      .|. ||  ..  |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  .  ||. .. ... ..||
eiekefelikkisdtsst.isqsiaeknqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQY--ILREFKVtdaRDGQSRTIRQFQFTDWPEQGVPKTgeGFIDFIGQVHKTKEQFGqD
.|||    . .. ...|| .  .. .|| ..|.   | .  .|  |  |.|.   ..  .. .  . .  |  .   |    .  ..| . | . . | .
lltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.n

GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
 |. |.||.||||.| |...   |||.. |||.|.|. .. .| ||...|.| ..|  ...   ||
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1369-1631 4.7e-41 135.3 In-house 31-297 (310) alignment
Range on Protein: 1369-1631
Range on HMM: 31-297/310.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTsIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLE
..|  .|  |. .      . .  ||||..|.  | ||| |. ||     ||| |||.     ....| .||||  |. |||||....|. ..... .  
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvg

EKSRVKCDQYWPARG-TETCGLIQVTLL----DTVELATYTVrTFALHKSG----SSEKRELR--QFQFMAWPDHGVPEYPTPILafLRRVKACnpLDAG
|. | ||  |||. | ||| | |.|| |    .  |.   .| ||   .       .. .|||    ..  ||| |||.     .   .|. |   .  |
eegrpkcvgywpslgvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaq..vrhg

PMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAtCGHTEVP
| |||||||..|... . ..  ...... . ||.   .| .. .|   .||| ||..|.   .  |  |.||| 
pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa.rgeteva

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1369-1621 7.6e-41 134.7 In-house 34-287 (305) alignment
Range on Protein: 1369-1621
Range on HMM: 34-287/305.0
QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILtsiDGVPGSDYINANYIDGY-RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRL
  |   |  |.    |   .... ||||..| . |.| | |   |  . |||| |||.      .. .|..|||| .|. .|| || ...   .||. . 
akytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlckt

EEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT-------YTVRTFALHKSGSsEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMV
 |  ..|| |||||   |   |    ... |  .          . .. |  ||. .|  .|..|.  ||| |||      | .|  ..  .     |.|
velgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgd.qkmsvrhlqwtewpdrgvppckltslellsairgsk....vpiv

VHCSAGVGRTGCFIVIDAMLERMKHEKTVD-IYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
||||||.||||  . |. .||..  .| .  .   | ..| || . .|.. ||.|||  .|.
vhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1384-1622 1.9e-40 133.3 In-house 31-268 (281) alignment
Range on Protein: 1384-1622
Range on HMM: 31-268/281.0
NSNLEVNKPKNRYANVIAYDHSRVILTS-IDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPaR
  |  ||. ||||.|. . | ||| |   .     .||| ||||     .  || ||||  ||  |||||.|.. |...||. .. |  | || .|.| |
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp.r

GTETCGLIQvTLLDTVEL--ATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRTGCFIVIDAML
 .  |  ..  |  . |      .. |  |  |   | | . .. .  |||  |||    .|  ||...|     . | |.||||||||.| .. ..  |
nahcclqfd.klsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveial

ERMKHEK-TVDIYGHVTCMRS-QRNYMVQTEDQYVFIHEALLEA
. ..      ||   |. .|   |   ||| .||..| . ||. 
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0051082 (Phosphotyrosine protein) phosphatases II 1706-1910 3.4e-39 129.2 In-house 2-149 (151) alignment
Range on Protein: 1706-1910
Range on HMM: 2-149/151.0
GSDYINASFLDGYrqqkaYIATQGPlaesTEDFWRMLWEHNSTIIVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . ||.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKtkeqfGQDGPITVHCSAGVGRTGVFITLSIVLERmryegvVDMFQTVKTLRTQRPAMVQTEDQYQL
  .........|||..|.| . . ...|. .. .      ..||. ||||||.||||... | ..|..      |....... .| .|| .||...|...
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYRAA
...| 
qlfal

subfamily_ptpA1_pd Subfamily ptpA1 1654-1874 6.1e-39 128.9 In-house 23-256 (418) alignment
Range on Protein: 1654-1874
Range on HMM: 23-256/418.0
MELEFKLLASSKAhTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRqQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
.. ||.||  |    |     .   |  |||  ||.| . ||| |. |.  |||||||| ..||    | .|.||||| ..  |||||.||    |||||
ikeefrlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivml

TKLREMGREKCHQYWPAERSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTK
..  |  | || .||| .     |. .       .  |     .. |   ||        . .|..| | |.|.  ||.. .|   . | ...  . . .
sresencrikcdrywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

EQF----GQDGPITVHCSAGVGRTGVFITLSIVLERM
.|      .. || ||||||||||| | |  |.....
nqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

0044763 (Phosphotyrosine protein) phosphatases II 1690-1913 1.9e-38 127.2 In-house 1-170 (178) alignment
Range on Protein: 1690-1913
Range on HMM: 1-170/178.0
PYELTRVCLQPIRGVEGSDYINASFLDGYrqqkAYIATQGPlaestEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||. ...     |.....|     .|....|.|.. | ||.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtiRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRTGVFITLSIVLERmryeGVvDMFQTVKTL
                      |.... .|  |||   | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... .. .
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDQYQLCYRAALEY
| .|| .|....|.. .|. .|..
rerRp.ivpnpgqlrqLyefelrl

0044763 (Phosphotyrosine protein) phosphatases II 1402-1619 2.6e-38 126.8 In-house 2-167 (178) alignment
Range on Protein: 1402-1619
Range on HMM: 2-167/178.0
YDHSRVILTSIDGVPGSDYINANYIDGYrkqnAYIATQGPlpetmGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTetcgliqvtlldtvela
.|..||.|... |...||||||..|...     |.....|      |......|.   ..|..|   |  ..|||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tytvrtfalhksgssekrelRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhekTVDIYGHVTCMRSQ
                     |.... .||||||. .  .|.|.. .... . . || .|||||||||.|...... |...      ....  .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYVFIHEAL
|. .|....|. ...|  
Rp.ivpnpgqlrqLyefe

0051082 (Phosphotyrosine protein) phosphatases II 1417-1620 3.8e-38 125.8 In-house 2-150 (151) alignment
Range on Protein: 1417-1620
Range on HMM: 2-150/151.0
GSDYINANYIDGYrkqnaYIATQGPLPetmgDFWRMVWEQRTATVVMMTRLEEKSrvKCDQYWPARGtetcgliqvtlldtvelatytvrtfalhksgss
 |||||..|..|.     .....|||.    ||.....|.   |.|... .||    .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAcnpLDAGPMVVHCSAGVGRTGCFIVIDAMLERmkhektVDIYGHVTCMRSQRNYMVQTEDQYVFIH
  .|....... |||.|.|...  .|.||. . .    . ||..||||||.||||...... ||..      |...  .  .|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EALL
 |||
fall

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1387-1622 4.7e-38 125.8 In-house 32-269 (285) alignment
Range on Protein: 1387-1622
Range on HMM: 32-269/285.0
LEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGY-RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE
 | |   ||||.| . . .||.|   |     ||| |...    . |..||.||||||||. |||.|..... | |.|.  | |    ||  |.| .  |
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

T--CGLIQVTLLDTVELATY----TVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAgPMVVHCSAGVGRTGCFIVIDAM
    |  ..|| .  | |         |    .  |||   . . |   |||.  ||   |.. . . ||  || .  |..||||||||||  |. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidya

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
  |.  .  ...   |  ||. |   ||.  |..|..  |.| 
tirimenpniemldivremramrfqavqshmqflflyvvlmey

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1673-1913 1e-37 124.3 In-house 31-268 (281) alignment
Range on Protein: 1673-1913
Range on HMM: 31-268/281.0
SANLPCNKFKNRLVNIMPYELTRVCLQP-IRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAE
  | | |. ||| .||   ...|| |.  .   . .||| | ..     .. || ||||  |.  |||||.|. |.| |||| .. |  |||| .|.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKtkeqfgQDGPITVHCSAGVGRTGVFITLSIVL
  .  |.  .    |    .  |   ..  . .|..| | .. . .||.  ||.. | ..  . ...       .  |  .||||||||.| .... | |
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveial

ERMRYE-GVVDMFQTVKTLR-TQRPAMVQTEDQYQLCYRAALEY
. ..    . |. | |  || | | | ||| .|| | ..  |..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1390-1621 1.6e-37 123.9 In-house 48-285 (305) alignment
Range on Protein: 1390-1621
Range on HMM: 48-285/305.0
NKPKNRYANVIAYDHSRVILtsiDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCG-
.. |||| .|   |. || |   .|    .|| |||.    . . .| || || .|  ||| | ....  .. |.  | ||   || .|....  ..   
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

-----LIQVTLLDTVEL-----ATYTVRTFALHKSGS-SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACnpldAGPMVVHCSAGVGRTGCFIVID
      |.| .  .|.|     |  .|.   |   |. ...|   .. .. ||| |||   . || .| . ..      ||.|||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvmle

AMLERMKHEKTVDIYGH-VTCMRSQRNYMVQTEDQYVFIHEALLE
 .|...   . ..   . .  .| |||  .||..||.|.|. .|.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

PTPc_DSPc_SM00012 1809-1912 8.7e-37 120.9 In-house 1-105 (105) alignment
Range on Protein: 1809-1912
Range on HMM: 1-105/105.0
TIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
|......|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . ||.||.|| ||.||| |||||.||. .|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAALE
|| ||
ralle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1681-1916 6.7e-36 118.4 In-house 58-285 (290) alignment
Range on Protein: 1681-1916
Range on HMM: 58-285/290.0
FKNRLVNIMPYELTRVCLQpiRGVEGsDYINASFLDGYRqqKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|.... |.|||. ... . |||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTkeqfgqDGPITVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |...   ..  .  . |.       ||..||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGS
  .|. ..|..||  | . || . || .  .. |..  .
keldlldlvralrnsrlnsvqvdiqylalveilldlGkd

PTPc_DSPc_SM00012 1521-1621 6.8e-36 118.0 In-house 2-105 (105) alignment
Range on Protein: 1521-1621
Range on HMM: 2-105/105.0
LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA--GPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
........||||||||....|| .|| || ..   .  .|.||||||||||||.|...| .|.....| |.|||.  |  .|.||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1390-1551 2.3e-34 113.6 In-house 33-196 (297) alignment
Range on Protein: 1390-1551
Range on HMM: 33-196/297.0
NKPKNRYANVIAYDHSRVILTsiDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTE
   |||| ...|.| .|| |    .....|||||.|.      ..  || .|||| .|. |||..|.||   ..||...|.|  | ||  |||    .  
slrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

TCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC
..| . |  | ..     .|    |.    ||.| .|  ||..|||||||     .  |  .| .|
kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

subfamily_CG42327_pd Subfamily CG42327 1390-1550 5.8e-34 112.2 In-house 28-192 (319) alignment
Range on Protein: 1390-1550
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRK-QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR----GT
 |.|.|..||.   ..||.| .|   . . |..|.|. ||.. .| |||.| .| ..  ||||.||||.. ..| .| | |.   .| .|.|..    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFmAWPDHGVPEYPTPILAFLRRVKA
.. | |.||| .      | . |. |..   .| |||  . .  |.. .||  .....| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1679-1914 1.7e-33 110.5 In-house 55-289 (305) alignment
Range on Protein: 1679-1914
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYELTRVCLQPIRgveGSDYINASFLDGY-RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   ... | |.       |||| | ..      .| .|..|||| .. ..|| |. ...   |||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHktkeqfGQDGPITVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. ..|..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
||..  .  .  | . ||.|| ||   .|.. ||   .|  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1390-1637 8.8e-33 108.6 In-house 43-284 (288) alignment
Range on Protein: 1390-1637
Range on HMM: 43-284/288.0
NKPKNRYANVIAYDHSRVILTsidgVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGL
|  ..|| |.   | .|| |.         ||.|| .   . ..  | .| ||  |.. .|.|. |.    .||...| || . | ..|.| .  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

IQV---TLLDTVELAtYTVRTFALHKSGSSEKRE-LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMVVHCSAGVGRTGCFIVIDAMLERMKH
 ..   .  . ...   .|.   |. |   |..  ...  .  |.|.||||   . | .| ..|...     |.|||.|||||||| .|.|  .|| .. 
grlctvvkkkradid.klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCgHTEVPARNLYA
.  . |   .. .| .|   .||| ||...|  .||     .  .. |....
ddflgirsllaklreerfkaiqtemqylyvhrcvleelll.kkykvlredfv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1710-1903 2.3e-32 106.9 In-house 78-270 (301) alignment
Range on Protein: 1710-1903
Range on HMM: 78-270/301.0
INASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | ...   . . .||||||| ...|||| ||  ..   ||||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgqdgPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY
 ..||.  .|...|...||||.     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||. | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1384-1614 5.5e-31 102.4 In-house 44-272 (301) alignment
Range on Protein: 1384-1614
Range on HMM: 44-272/301.0
NSNLEVNKPKNRYANVIAYDHSRViLTSIDGV--PgsdyINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA
.|.  ..| |.|| .|    .. |     ||   |    | ||.|.   . . .|||||||..|. ||| |.      ..||...  ||   ||..| | 
esyaylpkdkhryptvPckPstav.evivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

RGTETCGL--IQVTLLDTVELA--TYTVRTFALHK-SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNpldaGPMVVHCSAGVGRTGCFIVI
. .|.  .   .... ..  .     . ||. ..  .|  . | .  .|.. |.|.|||.  . .  ..  ||  .     |.|||||||.||. .||  
kisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigt

DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF
. .  ... ..|...   .  .| .|   |||. |  .
eylareveadptieltealkhlrehrwngvqtnsqlyw

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1679-1914 4.4e-30 99.6 In-house 35-270 (285) alignment
Range on Protein: 1679-1914
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYELTRVCLQPirgvEGSDYINASFLD-GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| |.  |||.|... . . ..||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  |.  .  ..|.. |. .|. |   ||.  |. . |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1669-1914 2.6e-29 97.2 In-house 33-271 (288) alignment
Range on Protein: 1669-1914
Range on HMM: 33-271/288.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW
|  |  .   |  ..|  |.   ..||| |.     .   ||.|  .   . ..  | .| ||    | .|.|| | .   ||||..| | |.||  .|.
sidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf

PAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKTGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRTGVFI
| .   .||.. .  .   ...  . ...   .   . |. .  ...  . .|...|||.    .. ..  .         . || ||.|||||||| .|
PsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtli

TLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
   |.|| .| .  . . . .. || .|   .||| ||   .|  ||.|
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1680-1914 8.3e-29 95.3 In-house 49-287 (305) alignment
Range on Protein: 1680-1914
Range on HMM: 49-287/305.0
KFKNRLVNIMPYELTRVCLQPirgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYF
. |||  ..   .  || |..       .|| | ..    . | .| || || ..  ||| | ....   | || .| | | .||..|....     .. 
agknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

------VVDPMAEYNMP------QYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRTGVFITL
      .|   .  ..         . .   | .   ...| . .. . |||..||| .    .... .   .|      |||.||||||.||||  . |
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvml

SIVLERMRYEGVVDM-FQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
  .|...    ...   . .. .| ||   .||..|| . ..  |.|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1517-1642 3e-28 93.3 In-house 87-213 (440) alignment
Range on Protein: 1517-1642
Range on HMM: 87-213/440.0
EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKAC-NPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
| | |.|... .|||.|||..  |.| ... |. . .    ||..||||||.||||  |..|..|   |.   .||.  . .||..|  |||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEALLEAATCGHTEVPARNLYAHIQKL
|||.||.  || | .   ..  .....
heavlegllcgdtliledditerveqi

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1391-1622 4e-28 93.0 In-house 44-275 (312) alignment
Range on Protein: 1391-1622
Range on HMM: 44-275/312.0
KPKNRYANVIAYDHSRVILTSIDGVpgsdYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--------
|  ||| |.  .|  |  |.  .      || ||..    | . ...||||| .|   ||...    ........ . | .  || .|            
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

---GTETCGLIQVTLLDtVELATYTVRTFALHKSGSSEKreLRQFQFMAWPDHGVPEYPTPILAFLRRVKAcnplDAGPMVVHCSAGVGRTGCFIVIDAM
    || |  |..      .  |. |    .. .|   |  | ..|. .|||||.|.     | .|  ||     |  |.. |||||||||| ...|..|
hrvyteycteieiggks.kdkithrvlkvvvkatgqesk..lnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesm

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.  ..| .  ..      .| .|   |..  |||.   ..|| 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_egg_pd Subfamily egg 1384-1619 4.1e-28 92.9 In-house 34-266 (307) alignment
Range on Protein: 1384-1619
Range on HMM: 34-266/307.0
NSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrVKCDQYWPARG
..  . |. | |   |   | ||| |    |    |.| ||...|    | .| .| || .|. ||||||....   .||.|   |    .|. |||   
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

TETC----GLIQVTLLDTVELATYTVRTFALHKS-GSSEKRELRQFQFmAWPDHGVPEYPTPILAFLRRVkacnpldAGPMVVHCSAGVGRTGCFIVIDA
...     | .... |.  . |    |   |.   |  |.| |  .|   .   .   .|  .|  ||..       . |.||..  || ...... |. 
sdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.......skpvvvqdilGvskaatlvaiei

MLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL
 |  .    .    .   |  .| .|.. |..  .|.|..  .
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv

subfamily_CG42327_pd Subfamily CG42327 1677-1841 1.6e-27 91.1 In-house 26-194 (319) alignment
Range on Protein: 1677-1841
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQK-AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| .|. ||||..|| .| .|| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFtDWPEQGVPKTGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .||   . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl

0048076 (Phosphotyrosine protein) phosphatases II 1493-1620 3.3e-27 90.3 In-house 18-140 (145) alignment
Range on Protein: 1493-1620
Range on HMM: 18-140/145.0
TLLDTVELATYTVRT-FALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDAMLErmkhEKtVDI
| ||  .|. . ..| . |    . ..|.  |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.    .. |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsl

YGHVTCMRSQRNYMVQTEDQYVFIHEALL
.  .  .|||| ..|....|. |..|..|
eealelvrsqrpgavpnpgqlrflyefel

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1719-1908 3.5e-27 89.9 In-house 2-198 (199) alignment
Range on Protein: 1719-1908
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTIRQFQ
. |. ||||| || |.  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKTG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM--RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYR
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.. |.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1720-1908 4.5e-27 89.5 In-house 2-197 (198) alignment
Range on Protein: 1720-1908
Range on HMM: 2-197/198.0
QQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTIRQFQF
 |. ||||| || |.  |||.|.||  |  |||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| | ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKTG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVLERM--RYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYR
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . ..|.. |.
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

0048179 (Phosphotyrosine protein) phosphatases II 1500-1617 1.9e-26 87.9 In-house 28-139 (144) alignment
Range on Protein: 1500-1617
Range on HMM: 28-139/144.0
LATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDaGPMVVHCSAGVGRTGCFIVIDAMLermkHEKtVDIYGHVTCMR
|  .|| ... .    ...||  |.... |||||||.... .|.||. .... . . ||..|||||||||||...... |.    ... ....  .  .|
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvr

SQRNYMVQTEDQYVFIHE
|.| ..|....|. |..|
srrpgavpnpgqlrfLle

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1679-1911 6.6e-25 82.3 In-house 52-287 (310) alignment
Range on Protein: 1679-1911
Range on HMM: 52-287/310.0
NKFKNRLVNIMPYELTRVCLQpIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQ
.  |||  ...  . .|| |. |      ||| | ..     ....| .||||  .  |||||...  .  |..| |  | || ||  |||.   .  | 
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

YFVVDPMAEYNMpQYILREFKVTDA-----RDGQSRTIR-----QFQFTDWPEQGVPKTGegfIDFIGQVHKTkeQfGQDGPITVHCSAGVGRTGVFITL
   |  ..|    .. . .. ||        | |   ..       .. .||..|||         . |   .  |  . ||  ||||||..|..| ..|
cirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvval

SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
 . .....    ||. . .  |. .|   .||| || .  |  .
klkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1392-1485 1.5e-24 81.4 In-house 49-156 (350) alignment
Range on Protein: 1392-1485
Range on HMM: 49-156/350.0
PKNRYANVIAYDHSRVILT----SID----GVPGSDYINANYIDGY---RKQN---AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ
 |||| |.. |.||||.|     | |     . ..|||||||.       ..|    |||||.|||.|. ||.... .     ....| . |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPARGTE
||.  . .
YWqegsyd

0048076 (Phosphotyrosine protein) phosphatases II 1794-1913 2.4e-24 81.0 In-house 36-142 (145) alignment
Range on Protein: 1794-1913
Range on HMM: 36-142/145.0
LrefkvTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQfgqDGPITVHCSAGVGRTGVFItlsiVLERMRYEGvVDMFQTVKTLRTQR
|     |. ... .|.. |.....||  |||   | ...|. ....  ..   .||. |||||||||||...    ..  |...| |....... .|.||
l.....tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqr

PAMVQTEDQYQLCYRAALEY
| .|....|.. .|.. ||.
pgavpnpgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1681-1770 1e-22 75.3 In-house 49-152 (350) alignment
Range on Protein: 1681-1770
Range on HMM: 49-152/350.0
FKNRLVNIMPYELTRVCLQ----P----IRGVEGSDYINASFLDGY----RQQKA--YIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQ
 ||| .||.||| .|| |.    .       ....|||||..|       ...    |||||.|| .  .||.... . . ..|..||.. |...|||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPA
||. 
YWqe

subfamily_egg_pd Subfamily egg 1651-1911 1.2e-22 75.0 In-house 13-267 (307) alignment
Range on Protein: 1651-1911
Range on HMM: 13-267/307.0
VTAMELEFKLLASSKAHTSRFISANlPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
|  .|  ...|  |  . |   .|.   |. | |   .   . .|| |.  ||    |.| |  ..|      .| .| || .. .|||||... .   |
vqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyi

VMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtiRQFQFTDWPEQGVPKTGEGFIDFigQVHKTKEQFg
||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .... .  .  .| .   .  
vmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnl.

qDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVV--DMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL
   |. |..  || ........ | |  .    ..   . ..|. || .|.  |..  .| . ||  |
.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1806-1915 1.7e-22 74.4 In-house 87-195 (440) alignment
Range on Protein: 1806-1915
Range on HMM: 87-195/440.0
QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQL
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|.|  ....| .|| |||| .|| .
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYRAALEYLG
 . | || | 
vheavlegll

0048179 (Phosphotyrosine protein) phosphatases II 1796-1908 2e-22 74.9 In-house 48-139 (144) alignment
Range on Protein: 1796-1908
Range on HMM: 48-139/144.0
EfkvtdardgqsrtIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRTGVFITLSivleRMRYEGvVDMFQTVKTLRTQRPA
|             . |.....||  |||   | ...|.  ...  |   ..||. |||||||||||.....     .|...| ........ .|..|| 
e.............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpg

MVQTEDQYQLCYR
.|....|.. ...
avpnpgqlrfLle

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1431-1616 2.7e-22 74.1 In-house 33-214 (255) alignment
Range on Protein: 1431-1616
Range on HMM: 33-214/255.0
KQNAYIAtqgplpeTMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS--SEKRELRQFQFMA
..| |.        |.  |....  ..| .|||.. ..|....||..|.|    |   | .|..  |   |   .||  .    .   . .... ...  
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPEYPTPILAFLRRVKacnplDAGPMVVHCSAGVGRTGCFIVIDAMLE----RMKHEKTVDI--YGHVTCMRSQRNYMVQTEDQYVFIH
|...  || .  ||  |. |.     |. ..|||||.|.||.  |.... .       ..  .||..     .. .||.|.  ..|  |  |  
WieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1431-1616 5.9e-22 72.8 In-house 3-197 (199) alignment
Range on Protein: 1431-1616
Range on HMM: 3-197/199.0
KQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQF
 |  ||||| || ||| |||.||||  .  .||.   . .  .    |||.   ||   | . ||    .  . ||. .. | ..       ||. ..||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MAWPDHGVPEYPT---PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIH
 .| ..  |.       ..|     |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1432-1616 1.3e-21 71.7 In-house 3-196 (198) alignment
Range on Protein: 1432-1616
Range on HMM: 3-196/198.0
QNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPAR--GTETCGLIQVTLLDTVELATYTVRTFALHKSG--SSEKRELRQFQFM
|  ||||| || ||. |||.||||  .  .||.   . .  .    |||.   ||   | . ||    .  . ||. .. | ..       ||. ..|| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPEYPT---PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT--VDIYGHVTCMRSQRNYMVQTEDQYVFIH
.| ..  |.       ..|     |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1559-1626 2.1e-21 70.1 In-house 1-68 (69) alignment
Range on Protein: 1559-1626
Range on HMM: 1-68/69.0
MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
||||||.| |||| || |   . |.| || |||.  |  ||  |  ||  | .|.|||.|| ||   |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1682-1920 2.1e-21 70.9 In-house 46-282 (312) alignment
Range on Protein: 1682-1920
Range on HMM: 46-282/312.0
KNRLVNIMPYELTRVCLQpirGVEgSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| ...  ||..     || |..|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEqfgqdgPITVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| . .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHY
.|.    .. ..   || .|   |..  ||  . |. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1560-1626 2.2e-20 66.8 In-house 1-67 (69) alignment
Range on Protein: 1560-1626
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCG
|||||.| |||| || |   . |.| || |||.  |  ||  |  ||  |..|.|||.|| ||   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1389-1621 4.3e-19 63.2 In-house 46-277 (303) alignment
Range on Protein: 1389-1621
Range on HMM: 46-277/303.0
VNKPKNRYANVIAYDHSRVILTSidgvpgSDYINANYIDGYRKQNAyIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTE---
 |  |||...||  |||.| |.       | || |.|..   ...| | || ||. |  |||.|. ||.   |...    |  ..  |  .|        
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

TCGLIQVTLLDTVELATYTVRTfALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPI-LAFLRRVKAC--NPLDAGPMVVHCSAGVGRTGCFIVIDAM-LE
    |.|  .  |||.   |    |  |  . |  |   .. |||   .|   .|  .  . ....   .  |. | |    .|.||.| | ....  | 
eersirvgefkrvelgdgwvlk.vlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

RMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
  . . ..|.   .  .|  | . ||   |. ...  | |
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1438-1615 5.7e-19 62.7 In-house 96-280 (302) alignment
Range on Protein: 1438-1615
Range on HMM: 96-280/302.0
TQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL--LDT-VELATYT------VRTFAL--HKSGSSEKRELRQFQF
   |  .|.  .| .. . ..| || .. . |.   || .|.  .  ..  . . |.  ..   .|. .|      . |  .  .|  .  |. .  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

MAWPDHGVPEYPTPILAFLrrvKACNPLDAGpMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI
 |||||| |. . . |  |   | |.      ..||||||||||| .. |   ..  ...|. |.   |. .|. |   ||.|.| ...
sawpdhGapkeaytaldil...kfcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

I-set Immunoglobulin I-set domain 33-124 6.4e-19 59.5 Pfam-A 1-90 (90) alignment
Range on Protein: 33-124
Range on HMM: 1-90/90.0
PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDgAGSVLRIQPLRVqRDEAIYECTATNSLGEINTSAKLSV
|.| . ..|..   |  ... |...|||.|...|.|.|....|..   ..... | . |.|.  .| .|| .|.|.||||.|. ...|.|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnvev.sDeGkYtckatnsagkaeakaeLkV

subfamily_hpo-7_pd Subfamily hpo-7 1431-1616 5e-18 60.0 In-house 36-220 (263) alignment
Range on Protein: 1431-1616
Range on HMM: 36-220/263.0
KQNAYIAtqgpLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS--SEKRELRQFQFMA
..| |.     | .|.  |....  ..| .|||..  .|....||..|.|    |   | .|..  |       ..|  | .  .   . ........  
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WPDHGVPEYPTPILAFLRRVKACNpldagPMVVHCSAGVGRTGCFIVIDAM----LERMKHEKTVDI--YGHVTCMRSQRNYMVQTEDQYVFIH
|...  || .  ||  |. ..        ..|||||.|.||.  | |.. .    .  ..  .||..     .. .||.|.  ..|  |  |  
Wiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

fn3 Fibronectin type III domain 325-405 1.3e-17 56.9 Pfam-A 2-85 (85) alignment
Range on Protein: 325-405
Range on HMM: 2-85/85.0
PPIDLVVTETTATSVTLTWDSG--NSEPVTYYGIQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPS
.| .| |.|.|.||.||.|.    ...|.|.| ..|| .|.... .|..  .|| .. . || | .|| ||| |||  | ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1682-1913 1.6e-17 57.9 In-house 54-284 (302) alignment
Range on Protein: 1682-1913
Range on HMM: 54-284/302.0
KNRLVNIMPYELTRVCLQpirgVEGSDYINASFLDGYRQQKAYIATQGPLAEST---EDFWRMLWEHNSTIIVMLTKLREMGReKCHQYWP--AERSARY
||.  ..  .. ..| |.     |  .|.||| ..    ..  | .| |  .|.   |.|||| .... . .|.| .  |. .   ....|  ..    |
knqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

QYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTI--RQFQFTDWPEQGVPKTGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
. . |     |.   .    .. .    .| | ..      .| |... ||.     |  . .|   ...   | .. .    |.|| |.|.|| ...|.
gkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavavek

MRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
.  .  . . ..||..|.|||..|.. .||   |.|.| |
lqkgkepnikeivksiRsqRpravdslkQyvslyiallly

fn3 Fibronectin type III domain 923-1004 2.4e-17 56.0 Pfam-A 3-85 (85) alignment
Range on Protein: 923-1004
Range on HMM: 3-85/85.0
PQNLHVTGLTTSTTELAWDPPVlaERNGRIISYTVVFRDINSQQ-ELQN-ITTDT-RFTLTGLKPDTTYDIKVRAWTSKGSGPLS
|.||.|.. |... .| |.||   ...| | .|.| .|. .... . .  .. .| ..|||||||.|.| ..|.| . .| || |
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 613-700 4.4e-17 55.2 Pfam-A 2-85 (85) alignment
Range on Protein: 613-700
Range on HMM: 2-85/85.0
PPQKVMCVSMGSTTVRVSWVPPPadSRNGVITQYSVAYEAVDGEDrgRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES
.|. . . ...||....|| ||.  ...| || |.| |. ..|..   ..   ..| ..|  | ||.  |||...|.|....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1716-1903 5.9e-17 56.1 In-house 84-277 (302) alignment
Range on Protein: 1716-1903
Range on HMM: 84-277/302.0
DGYRQQKAYI-ATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  ...| .| .. ..| .|.| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIgqvhKTKEQFGQDgpITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQY
. . .|.  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|.| 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql





subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1734-1900 9.3e-17 55.9 In-house 40-207 (255) alignment
Range on Protein: 1734-1900
Range on HMM: 40-207/255.0
STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTIRQFQFTDWPEQGVPKTGEGFI
. . |....   ... .|||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .|.. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPITVHCSAGVGRTGVFITLSIVLERMR------YEGVVDMFQTVKTLRTQRPAMVQTE
  .  |...|       .. ||||.|.||.  |.   .|  .|         . .|  . .. || .|.. ..| 
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1387-1620 1.3e-16 55.0 In-house 48-282 (302) alignment
Range on Protein: 1387-1620
Range on HMM: 48-282/302.0
LEVNKPKNRYANVIAYDHSRVILTSIDgvpgSDYINANYIDGYRKQNAYIATQGPLPETM---GDFWRMVWEQRTATVVMMTRLEEKSRvKCDQYWP--A
   |  ||.  .| ..|. .|.|.        .|.||  ..    ..  | .| |  ..     .|||||.... ..||.. . || ..   ....|  .
fkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

RGTETCGLIQVTLLDtVELATYTVRTFAL--HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAM
   .. | . |     || |  ..  ...     | |.        .  |... ||.  . . .    | | .     ..|.    |.|| | |..  . 
gdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALL
.|.....| . |   |. .||||  .|.. .|||... |||
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall

fn3 Fibronectin type III domain 518-596 2.6e-16 52.7 Pfam-A 2-83 (85) alignment
Range on Protein: 518-596
Range on HMM: 2-83/85.0
QPADFQAEVESDTRIQLSWLLPP--QERIIMYELVYWAAEDED-QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGV
.| .....  ..| ..|||  |.  .. |  ||. |. .....  ... .  .|.|.||..|||.| |.|...|... | | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1346-1440 3.4e-16 53.2 In-house 4-95 (95) alignment
Range on Protein: 1346-1440
Range on HMM: 4-95/95.0
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDgvpGSDYINANYIDGYRKQNAYIATQG
|| .. .   .  ...|   .| .|. ||      ..     | | ||||. |.. || .||.||.      |||||| ..||| ..|.|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1388-1618 5.4e-16 53.6 In-house 17-254 (290) alignment
Range on Protein: 1388-1618
Range on HMM: 17-254/290.0
EVNKPKNRYANVIAyDHSRVILTSIDGVPGSDYINANYIDgYRKQNAYIATQGPLPET-------MGDFWRMVWEQRTATVVMMTRLEEKSRV----KCD
. .. ..|... ..  ..||.|        .||| ||..  . .  . |.|| |. ..       . .|| |. . .   |||.   ||||.      | 
kkhemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

QYWPARGTET--CGLIQVTLLDTVELATYTVRTFALhKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKaCNpldAGPMVVHCSAGVGRTGCFI
.| | .  |    . ..|   . ..     .|.  . | .  |.  .   ..  | .  |.| .  .|. .. || ..     |..|||  |. |  .. 
kYvpesvgeelkfkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAala

VIDAMLERMK-HEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA
 |.     .   .. | .   .  .|.||. ..... .. |.  .
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdag

fn3 Fibronectin type III domain 715-813 8e-16 51.1 Pfam-A 2-85 (85) alignment
Range on Protein: 715-813
Range on HMM: 2-85/85.0
PPRKVEVEPLNSTAVHVYWKLPVpsKQHGQIRGYQVTYVRLENGEprglpiiqdvmlaEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARS
.|. . |.. .|| ... |. |   ...|.| ||.|.|   ..||             | ...  ..  .. |..||.| |.|...|.|....| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_CG42327_pd Subfamily CG42327 1846-1913 8.1e-16 52.6 In-house 246-314 (319) alignment
Range on Protein: 1846-1913
Range on HMM: 246-314/319.0
QDGPITVHCSAGVGRTGVFITLSIVLERMRYE-GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
. ||..|||| ||||||. |.  | ....      ||. |.|  .| .|   |.| .||.. |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_CG42327_pd Subfamily CG42327 1555-1621 9.3e-16 52.4 In-house 246-313 (319) alignment
Range on Protein: 1555-1621
Range on HMM: 246-313/319.0
DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE-KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
. ||.||||| ||||||  |  |  ......  ..|||   |  .| .|   |.| .|| ||.  | |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1392-1480 2e-15 50.9 In-house 50-154 (349) alignment
Range on Protein: 1392-1480
Range on HMM: 50-154/349.0
PKNRYANVIAYDHSRVILT--------------SIDGVPGSDYINANYIDGY--RKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKC
 |||| ... |.||||.|                 |.    |||||||.       .. ||||| ||| |. ||....  ..   |. ..  .|.|  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWP
|.|| 
diywq

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1516-1620 3.5e-15 50.6 In-house 212-341 (350) alignment
Range on Protein: 1516-1620
Range on HMM: 212-341/350.0
SEKRELRQFQFMAWPDHGVPEYPTPILAFLR-------RVKACNPL---DAGPMVVHCSAGVGRTGCFIVIDAMLE----------RMKH----EKTVD-
|.  .. |.|.  |.| ..   |  ||  |           | . |    . |..||||||||||| .. .| .|.          ....     || | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

IYGHVTCMRSQRNYMVQTEDQYVFIHEALL
|   |  .|.||  |||. ||..||.||||
isiivnelrkqrismvqnldqfifiYeall

fn3 Fibronectin type III domain 419-504 3.6e-15 49.0 Pfam-A 1-85 (85) alignment
Range on Protein: 419-504
Range on HMM: 1-85/85.0
SPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPpnAWHKHNTDAGL-LTTVGSLLPGITYSLRVLAFTAVGDGPPS
|.|......  ..... ..|.||....| . ||.| | ...     .|.  ....     |.  | || .|..|| | ...| ||.|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1810-1913 3.9e-15 50.4 In-house 217-343 (350) alignment
Range on Protein: 1810-1913
Range on HMM: 217-343/350.0
IRQFQFTDWPEQGVPKTGEGFIDFIG--------QVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLE----------RMR----YEGVVD-MFQTV
. |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.          ..|       . | ....|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KTLRTQRPAMVQTEDQYQLCYRAALEY
. || ||  |||. ||.  .| |.| |
nelrkqrismvqnldqfifiYeallfy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1672-1771 5.5e-15 49.6 In-house 89-181 (244) alignment
Range on Protein: 1672-1771
Range on HMM: 89-181/244.0
ISANLPCNKFKNRLVNIMPYELTRVCLQpiRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrekCHQYWPAE
  |  | | .|||    .|... || |   .|  |  ||||||.    .   || || |||... |||.|. |    ..|.|  . |       .|||  
kdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds





subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1390-1513 7.3e-15 49.3 In-house 34-158 (332) alignment
Range on Protein: 1390-1513
Range on HMM: 34-158/332.0
NKPKNRYANVIAYDHSRVILTSIDGVpgSDYINANYIDGYRKQNAYIATQGPLPE-TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCG
|   ||   . ..||||| |.  ||    |. ||...||| |..||| .| |. . |   ||||| |.. . ....  ..|| . |.      || |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

LIQV--TLLDTVELATYTVRTFALHKS
| ..    |. .|| .  .| |   |.
lhefgaksleecelkakicrkfwpekr

I-set Immunoglobulin I-set domain 135-216 7.9e-15 46.4 Pfam-A 1-82 (90) alignment
Range on Protein: 135-216
Range on HMM: 1-82/90.0
PSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPatsNGRIKQLRSG---ALQIESSEESDQGKYECVATNSAGTR
|...  ..  .|..  .... | . |.|.|..||.||  .. .   . |.|   ..    | |.. |.||.|||.|.||||||..
pkftqklkdvevseGesvelectveGepepsvsWakdgselks...sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagka

subfamily_eak_pd Subfamily eak 1394-1549 3.7e-14 46.9 In-house 56-208 (332) alignment
Range on Protein: 1394-1549
Range on HMM: 56-208/332.0
NrYANVIAYDHSRVILTSIDGVPgSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGT--ETCGLIQ
|   ... ||.  | |||    .   ||||  ..     . || |  .  . .  ||.|| ||.. ..|..    |.   | |.|.| ..      | ..
n.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTLLDTVELATYTVRTFALHKSgsSEKRELRQFQFMAWPDHGVPEYPtPILAFLRRVK
|.  . |. . . .| . |.|    |  ..  ...  | .  .| |    ||. . .|
verkefvkrniletrllelskG..nethrvlhykvfGwtettlpkye.dflalrkvmk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1682-1904 3.9e-14 47.5 In-house 22-249 (290) alignment
Range on Protein: 1682-1904
Range on HMM: 22-249/290.0
KNRLVNIMpYELTRVCLQPIRGVEGSDYINASFLDgYRQQKAYIATQGPLAES-------TEDFWRMLWEHNSTIIVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |...         |.|| |  . ... .||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  |.   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQ
.    .   .| | . . .|.|| ||  ..... .. 
lgyQkiaetsgsvkledvlkalrkqralaitsalela

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1547-1621 4.9e-14 46.9 In-house 220-293 (297) alignment
Range on Protein: 1547-1621
Range on HMM: 220-293/297.0
RVKACNPLDAgPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
 ..|  | .| ...|||||||||.|  .  |..|.......  |.   .. .|.||  .||| .|. ....| |.
slraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

fn3 Fibronectin type III domain 836-906 6.2e-14 45.1 Pfam-A 12-83 (85) alignment
Range on Protein: 836-906
Range on HMM: 12-83/85.0
AMNTALLQWHPPKELPGELLGYRLQYCRADEAR-PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGE
  ... |.| |||.  |.. ||...|. ... . .....  .. ...|.|||  ||.| ||..| |.|| |.
tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1852-1913 8.7e-14 45.6 In-house 2-63 (69) alignment
Range on Protein: 1852-1913
Range on HMM: 2-63/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY
||||.| |||| ||.. . . |.. | .||.|  |. .|  || ||  |..| . . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1851-1912 9.4e-14 45.6 In-house 2-63 (69) alignment
Range on Protein: 1851-1912
Range on HMM: 2-63/69.0
TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
 ||||.| |||| ||.. . . |.. | .||.|  |. .|  || ||  | .| . . |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_hpo-7_pd Subfamily hpo-7 1731-1899 1e-13 45.8 In-house 43-212 (263) alignment
Range on Protein: 1731-1899
Range on HMM: 43-212/263.0
LAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTIRQFQFTDWPEQGVPKTGE
| .  . |....   ... .|||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .|....... |.|.  |.  .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

GFIDFIGQVHKTKEqfgqdgpITVHCSAGVGRTGVFITLSIVLERMR------YEGVVDMFQTVKTLRTQRPAMVQT
  .  .  . . |.       . ||||.|.||.  |    .|  .|         . .|  . .. || .|.. ..|
eilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1346-1428 2.1e-13 44.4 In-house 5-85 (440) alignment
Range on Protein: 1346-1428
Range on HMM: 5-85/440.0
PIPITDLADNIERLKAndGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDG
|| ..|.|| ..  .      | .|.  .  | .   . ..|  || |||| |..|||||||.|  . ||| |||||| ||.|
piivadfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1427-1508 6.2e-13 42.9 In-house 230-309 (440) alignment
Range on Protein: 1427-1508
Range on HMM: 230-309/440.0
DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSrvkCDQYWPARGT-ETCGLIQVTLLDTVELATYTVRTF
.|| |.||.|||| ||  |. ||||.| . | .|..|. .|..|.   |  |||      | | . |    . ..    |||.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1657-1729 6.3e-13 42.7 In-house 28-95 (95) alignment
Range on Protein: 1657-1729
Range on HMM: 28-95/95.0
EFKLL--ASSKAHTSRFISANLPcnkfKNRLVNIMPYELTRVCLQPIRgveGSDYINASFLDGYRQQKAYIATQG
||| .  .|  ..|     ||.|    |||..||.||. |||.|   |    |||||| |.||| ....|||.||
efksismtsgapytvgsseanip....knrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_eak_pd Subfamily eak 1682-1833 9.1e-13 42.3 In-house 55-203 (332) alignment
Range on Protein: 1682-1833
Range on HMM: 55-203/332.0
KNrLVNIMPYELTRVCLQPIRgVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. | .|  ||.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTgEGFIDF
|    |. . . ||.  ..   .  ..  .  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1679-1910 1.7e-12 41.6 In-house 47-275 (303) alignment
Range on Protein: 1679-1910
Range on HMM: 47-275/303.0
NKFKNRLVNIMPYELTRVCLQpirgveGSDYINASFLDGYRQQKAyIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA-RYQ
|  |||.|...  . ..| |        | || ||.|.   ..|| | || ||. .. |||.|. | .   ...|    |. .   .  .| ..   ...
nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRT-IRQFQFTDWPEQGVPKTG-EGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLER
  .  |  . . .. .     .||    .|. .. .   .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .      
ersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

MR-YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA
.   .  .|. . ....|  |   ||   |. . |   
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll

I-set Immunoglobulin I-set domain 236-319 2.1e-11 35.4 Pfam-A 1-90 (90) alignment
Range on Protein: 236-319
Range on HMM: 1-90/90.0
PRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNV----LELSNVVRS--ANYTCVAISSLGMIEATAQVTV
|.|.......||. | ||.|.| . | | | |.|. . .||...... |  .     |..||| .|   .|||.|  |.|  ||.|...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1682-1769 4.3e-11 36.7 In-house 51-154 (349) alignment
Range on Protein: 1682-1769
Range on HMM: 51-154/349.0
KNRLVNIMPYELTRVCL----QPIRGVEGS----------DYINASFLDG--YRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| .|    .  .| ||||| ||  . .||....   .  ... |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1385-1464 7.1e-11 36.2 In-house 32-116 (347) alignment
Range on Protein: 1385-1464
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDG-----VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMM
.. | .  |||  .|   | .||.|.  .       .   |||| .|     .. || || |||.|. |||.||   . . || .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1690-1822 1.6e-10 35.4 In-house 4-125 (130) alignment
Range on Protein: 1690-1822
Range on HMM: 4-125/130.0
PYELTRVClqpirgveGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYN
..|..|.         | .||||||.    . . |. || |||... |||.|. |    ..|.|  . |       .|||       |.  ..  ... .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrd

MPQYILREF-KVTDARDGQSRTIRQFQFTDWPEQG
  ..|  .. .. .      ...  || ..|| .|
efknikasnleiesdlneshqaltmfqisnwpsdg

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1679-1763 1.9e-10 34.7 In-house 34-117 (332) alignment
Range on Protein: 1679-1763
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYELTRVCLQPIRGVEgsDYINASFLDGYRQQKAYIATQGPLAESTED-FWRMLWEHNSTIIVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. |.. ..|...  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1843-1914 2.7e-10 34.1 In-house 261-344 (349) alignment
Range on Protein: 1843-1914
Range on HMM: 261-344/349.0
QFGQDGPITVHCSAGVGRTGVFITLSIVLE--R--------MRYEGVV-D-MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL
.  |  .. |||||| |||||..|| ..|.           . .. .  | .. .| .|| || .|||   |.  .| | |.|.
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1653-1718 3.8e-10 33.7 In-house 23-86 (440) alignment
Range on Protein: 1653-1718
Range on HMM: 23-86/440.0
AMELEFKLLASSKAHTSRFisANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGY
|.| |. || |. .. |    |.|| || |||  ||. |. .|| |. ..||  |||||||...| 
afedewsllpsglsqpsdi..aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1716-1795 5.7e-10 33.1 In-house 230-307 (440) alignment
Range on Protein: 1716-1795
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  .  ||||.. ... . |.|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1375-1430 1.6e-09 31.8 In-house 24-78 (244) alignment
Range on Protein: 1375-1430
Range on HMM: 24-78/244.0
DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDgVPGSDYINANYIDGYR
|  ..|   |. | .|  |||| |.. .|..||||.|     ||||||||||.| .
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsq

subfamily_PTPDC1_pd Subfamily PTPDC1 1838-1907 2e-09 32.1 In-house 105-169 (182) alignment
Range on Protein: 1838-1907
Range on HMM: 105-169/182.0
HKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVlermrYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .| .|. 
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvk

Ig_2 Immunoglobulin domain 142-223 2.1e-09 29.3 Pfam-A 8-78 (80) alignment
Range on Protein: 142-223
Range on HMM: 8-78/80.0
QlKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNgrikqlrsgaLQIESSEESDQGKYECVATNSAGTRYSAPANL
.  ||..  . |. |.| |||.|...| ||  .... ...          | | . ...|.|.|.|.|.|| |   | . ..
p.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna..........lfipnvsaedsGtYtCrasnsegskqsnsvev

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1518-1621 2.2e-09 31.1 In-house 217-342 (349) alignment
Range on Protein: 1518-1621
Range on HMM: 217-342/349.0
KRELRQFQFMAWPDHGVPEYPTPILAFLRrVK--------ACNPL---DAGPMVVHCSAGVGRTGCFIVIDAMLE--RMKHE---------KTVD-IYGH
  || |.|.  |.| ..   |  ||  |  ||        | . |   .  ...|||||| |||| .. .| .|.   . ..         .. | |.  
PyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VTCMRSQRNYMVQTEDQYVFIHEALLE
|  .| ||  |||   |...|.||||.
vnelrkqrismvqnlaqfiaiyealLk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1412-1533 2.8e-09 31.4 In-house 7-125 (130) alignment
Range on Protein: 1412-1533
Range on HMM: 7-125/130.0
IDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvkcDQYWPARGTET--CGLIQVTLLDTVELATYTVRTFA
.. ..| .||||...    . . |. || || .|  |||.|. |.    .|..  .||.     |.|||           | ||| |  |        . 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

LHKSGSSEKRELRQFQFMAWPDHG
 ..     .. |  ||   ||  |
iesdlneshqaltmfqisnwpsdg

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1673-1772 5.6e-09 29.1 In-house 21-88 (169) alignment
Range on Protein: 1673-1772
Range on HMM: 21-88/169.0
SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAsfldgyrqqkayiatqgplaestedfwRMLWEHNSTIIVMLTKLremgrEKCHQYWPAER
 |.| ||. |||    .    ||| || .    |||||||                           ||.|| |...||.|        .   ..||   
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpeke





0038934 (Phosphotyrosine protein) phosphatases II 1818-1909 5.9e-09 31.3 In-house 85-172 (194) alignment
Range on Protein: 1818-1909
Range on HMM: 85-172/194.0
W--PEQGVPKTGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRTGVFITLSIVL-ERMryegvvDMFQTVKTLRTQRPAMVQTEDQYQLCYRA
.  |..|.. . |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .. . ....|  || .... |...  .. 
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallkr

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1672-1771 6.4e-09 28.9 In-house 19-86 (169) alignment
Range on Protein: 1672-1771
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINAsfldgyrqqkayiatqgplaestedfwRMLWEHNSTIIVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |...||.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek





subfamily_PTPDC1_pd Subfamily PTPDC1 1524-1617 4.5e-08 27.7 In-house 85-170 (182) alignment
Range on Protein: 1524-1617
Range on HMM: 85-170/182.0
FQFMAWPDHGVPEYpTPILAFLRRVKacNPLDAGPMVVHCSAGVGRTGCFIVIDAMlermkHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHE
.  ..|.|.||.   . ||   . |.    |. | . ||| || ||||  |    .     . | ..    .. .||.|   .|| .|  ...|
vynfgwkDygvasl.eriLdivkvva..falqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvke

0038934 (Phosphotyrosine protein) phosphatases II 1527-1610 7.1e-08 27.8 In-house 85-164 (194) alignment
Range on Protein: 1527-1610
Range on HMM: 85-164/194.0
MAWPDHGVPEYPTPILAFLRRVKACNPLDA-GPMVVHCSAGVGRTGCFIVIDAMLeRMKHeKTVDIYGHVTCMRsqrNYMVQTED
. .||.|..     .| ||. |.  .  |. |  .||| ||.||||....   .  |..  .  . ..... .|   . .... |
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.rlgm.saeeAialfrekR...pgaipnqd

Ig_2 Immunoglobulin domain 49-124 7.5e-08 24.3 Pfam-A 16-80 (80) alignment
Range on Protein: 49-124
Range on HMM: 16-80/80.0
VASFVCQATGEPKPRITWMKKGKKVSSQRFEviefddgagsvlRIQPLRVQRDEAIYECTATN-SLGEINTSAKLSV
   . |||.| |.|...| |.|...|... .             ..|.    |  .|.|.|.| .... ..| .. |
nvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv

Ig_2 Immunoglobulin domain 240-319 8.9e-08 24.1 Pfam-A 4-80 (80) alignment
Range on Protein: 240-319
Range on HMM: 4-80/80.0
IPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTkedempVGRN--VLELSNVVRSANYTCVAIS-SLGMIEATAQVTV
. .....|  | .|.||| | | | | |.|  . |||.       ..|   . . ..  | .|||.|   ....   . .|||
lsapptvvtegenvtLtCqapgnptpkvqwykdgeels......qsqnalfipnvsaedsGtYtCrasnsegskqsnsvevtv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1433-1534 1.1e-07 25.7 In-house 137-235 (244) alignment
Range on Protein: 1433-1534
Range on HMM: 137-235/244.0
NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKsrvkcDQYWPARGT-ET-CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWP
  || || || .|  |||.|. |.    .|..  .||.     |.|||     |     | ||| |  |.       . .       .. |  ||   ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV
  | 
sdgt

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1385-1481 1.6e-07 24.4 In-house 22-86 (169) alignment
Range on Protein: 1385-1481
Range on HMM: 22-86/169.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAnyidgyrkqnayiatqgplpetmgdfwRMVWEQRTATVVMMTRLEEKSrvkcdQYWPA
..| .|. ||| |  .|  | || |  .    |||||||                           ||.||  .. .|..   ..|      ..|| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn.....nfwpe

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1669-1753 2.5e-07 24.5 In-house 27-116 (347) alignment
Range on Protein: 1669-1753
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-----SDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVML
|.| |..   .  |||  .    . ||| | | .   .       ||||| .     .| || || || ..  |||.|.   . | .| .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1385-1481 2.6e-07 23.6 In-house 21-85 (169) alignment
Range on Protein: 1385-1481
Range on HMM: 21-85/169.0
SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINAnyidgyrkqnayiatqgplpetmgdfwRMVWEQRTATVVMMTRLEEKSrvkcdQYWPA
..| .|. ||| |  .|  | || |  .    |||||||                           ||.||  .. .|..   ..|      ..|| 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn.....nfwpe

subfamily_eak_pd Subfamily eak 1544-1622 3.5e-07 23.9 In-house 226-304 (332) alignment
Range on Protein: 1544-1622
Range on HMM: 226-304/332.0
FLRRVKACNPLDAgPmVVHCSAGVGRTGCFIVIDAMLeRMKHEKTVDIY---GHVTCMRSQRNYMVQTEDQYVFIHEALLEA
.|.. .   |  | | .. .. |  |.| |.||| .. |.  .|  . |     .  ..|.|.. | .. |. ||.|..|. 
tlkkyihtppsfa.p.iiqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

Ig_3 Immunoglobulin domain 148-211 1.5e-06 20.4 Pfam-A 17-75 (75) alignment
Range on Protein: 148-211
Range on HMM: 17-75/75.0
KartATMLCAAGGNP-DPEISWFkdfLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATN
.    |  | | |.|  | |||       .|  .. ...   .. | |.|  ..| | |.|||.|
n...vtLtCsaeggpppptisWy...ietppelqgsegssssestLtissvtsedsGtYtCvasN

subfamily_PRL_pd Subfamily PRL 1839-1885 2.5e-06 21.6 In-house 82-128 (151) alignment
Range on Protein: 1839-1885
Range on HMM: 82-128/151.0
KTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQT
|.| .   .  ..||| ||.||. |...|... . |.||  |.. ..
kekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefire

Ig_3 Immunoglobulin domain 38-111 4.6e-06 18.8 Pfam-A 6-75 (75) alignment
Range on Protein: 38-111
Range on HMM: 6-75/75.0
VPEDQTGLSGGVASFVCQATGEP-KPRITWMkkgkKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAiYECTATN
|.  .|  |||  .. |.|.| | .|.|.|.    .  .. ..  |  .. .|.| | .   . .   |.|.|.|
vspsptvtsggnvtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvtsedsGt.YtCvasN

PTPc_motif_SM00404 1803-1899 5.6e-06 21.3 In-house 42-127 (140) alignment
Range on Protein: 1803-1899
Range on HMM: 42-127/140.0
RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRTGVFItlsiVLERMRYEGVvDMFQTVKTLRTQRPAMVQT
.  ....| | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||... .. . .. .. .||.. ..
kensgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrql.slaeayefvkerRpiispn

Ig_3 Immunoglobulin domain 236-304 5.9e-06 18.4 Pfam-A 2-73 (75) alignment
Range on Protein: 236-304
Range on HMM: 2-73/75.0
PRFSIPPSSQEVMPGGsVNLTCVAVGAP-MPYVKWM-MGAEELTKEDEMPVGRNVLELSNVV--RSANYTCVA
|  |..||. ..  |. |.||| |.| |  | . |.  .  || . .    . ..| .|.|    | .|||||
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCva

subfamily_CDC14_pd Subfamily CDC14 1847-1905 6.9e-06 20.1 In-house 263-316 (328) alignment
Range on Protein: 1847-1905
Range on HMM: 263-316/328.0
DGPITVHCSAGVGRTGVFITLSIVlERMRyegvVDMFQTVKTLRTQRPAMVQTEDQYQL
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  |  |
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqqkfl