Gene PTPRS in Homo sapiens

Synonym: PTPSIGMA, PTPRS

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP098_AA protein Get Run
HsapP098_AA_1375-1650 phosphatase_domain Get Run
HsapP098_AA_1662-1941 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1370-1696 3.3e-172 569.0 In-house 2-329 (564) alignment
Range on Protein: 1370-1696
Range on HMM: 2-329/564.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
..|||.|...||...||||..||...||..|..|||||||..| ..||.||||||..|||||||.|...||  |||||||...|||| ..|||||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLA
||. |||||||||.|.||||.|.||||.. ||..|||..|||||| ..||| .. |||....|||.|.|. |||.||||||.||.||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
..|.|...|.||||||||||||||||||.|||||||||||| |||||.|..|...|.|||.|||||.||.|||||.|||. ||||||....|.. .||||
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QVEPGEHVTGMELEFKRLANSK-AHTSR
.||.....||.||||.|||..|  ....
eveedtemtgleleFqrLatakeielee

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1373-1687 9.5e-135 443.7 In-house 2-318 (318) alignment
Range on Protein: 1373-1687
Range on HMM: 2-318/318.0
IPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|.. |...| .||... .|.||.||| ...  ...|. .|. .||| ||||||..||||.|| ||..|| .|||||||||.|||| ..||||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
. ||||||||| ||.|||.|..||....|...|||..|...|| ..|.| ...||... .|.|........|.|.|||...|.|||.|||| .. .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQ
|.|.. . ...|||||||||||||||| ||..|..||||| |..|||.. |. .|.||| |||||||| ||...||||. .|.||| |. | . |..| .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

VEPGEHVTGMELEFKRL
..|    | |..||.||
qdpesgttemdaefqrl

subfamily_PTPRD_pd Subfamily PTPRD 1693-1945 1.6e-128 424.8 In-house 36-286 (564) alignment
Range on Protein: 1693-1945
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|...||.|....|.|||||||||||||||..|||||||||||||.||||||.||.||...||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||.||||.||.||..|||.|.....|.| .|....|   . ||| |||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH
....|||...|..|||.|.||.||.||.||||||. |.|...| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1372-1685 1.5e-118 390.5 In-house 4-319 (319) alignment
Range on Protein: 1372-1685
Range on HMM: 4-319/319.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
.|......|....|... . .| .|.. .. ....|..... | ||.|||| |..|||..||.|....|. |||||||...|||. ....||||.|| .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAF
. ||||||||..| ..||.|.| || ..|. .|||.   |.|| . |||..  ||. . .| ..|.|.    | ||| .||.|.||||.|||. |  |..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
|.|..     ...||||||||||||||| |||.||||||.| | ..||.  |  .| ||| |||...||.||.||||||| .|.||.  . |   ...||
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QVEPGEHVTGMELEFK
. ...   ||.| ||.
ekvadtgetglerefq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1678-1947 1.3e-116 384.1 In-house 20-287 (318) alignment
Range on Protein: 1678-1947
Range on HMM: 20-287/318.0
TGMELEFKRLANSKAHTSRFISaNLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
. .. |..||. |....... | . |.||.||| .||..|..||| ||.. |.||||||||..|||||..|||||.|.||.|| ||||||.|| ||...|
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdGPIS
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||.|||...|.||..|||.|| ...|...||.|.... |. ||| 
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..|||||| |.|.|.. ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

0040438 (Phosphotyrosine protein) phosphatases II 1376-1688 1.8e-113 374.2 In-house 3-315 (317) alignment
Range on Protein: 1376-1688
Range on HMM: 3-315/317.0
ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF
 |. .. ..|...|  .|..|.| ..  .  |.....|..||.|||| ... ||||||.|.|..|...||||||.||||.......||||||||.|..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVK
|||||||.. .|||.|.|||..|.||.||||...| ||| ..||||...||| ...||. . ..|.||.|.|..|..|.|||||||..|...|.||..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGE
...... ||..|||||||||||.||... |||... |..|||.  |  .|.||...|||..|| |...|||| . ...| .|| .|. ...|| .. ...
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

HVTGMELEFKRLA
 |...| |.|.| 
dvklkekelklll

subfamily_PTPRG_pd Subfamily PTPRG 1373-1662 2.2e-112 371.1 In-house 1-300 (563) alignment
Range on Protein: 1373-1662
Range on HMM: 1-300/563.0
IPIADMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGS-DYINANYVDGYRCQNAYIATQGPL
.|. ..|.|   |.|..  ..|.|.|..      .... |||. . || |||| |..|||.||| |.|. |. .. |||||||.|||. ..|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK----NGSS--EKREVRQFQFTAWPDHGVPE
..|| |||||.|||..|.|||.| |.|. | |||.|||. ..|||| .|||| ..  ||.  |||.....    ....  ....|||...| ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY
...| | | .. .. |. .|||||||||||||||| .||.|..|..|. |..|.|.| .  .|.|||..||||.|| |.|.|||||.  ..||. |  . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve





0051299 (Phosphotyrosine protein) phosphatases II 1370-1648 3.4e-110 363.2 In-house 2-285 (288) alignment
Range on Protein: 1370-1648
Range on HMM: 2-285/288.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
. .|.. ..... ..|.||.  .| .|.| . . . ..|. ...|. |..|||| ....||||||.|....|. |||||||.|.|||......|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN----GSSEKREVRQFQFTAWPDHGVPEYP
|.|..|||||||||.. .|||.|.|.|..|.||.||||..|..||| |.||||.. .|....|||. . ..    |..|.|.|..|..|.|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
...|.|||.|....... ||.||||||||||||.||..| .||... |..|||.. |  .|.||..||||..|| |..|||||.
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_PTPRK_pd Subfamily PTPRK 1370-1683 2.4e-109 360.0 In-house 1-311 (314) alignment
Range on Protein: 1370-1683
Range on HMM: 1-311/314.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGqqftWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
|| | .||. ..   ||....  . .||||.  |    |. .. . |. |||. ...|||.|||.|..|.|   ||||||...|.|.  .|.|.|||||.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTEtYGFIQVTLLDTIELATFCVRTFSLHK--NGSSEKREVRQFQFTAWPDHGVPEYPTPF
||  ||||.|.....|.|||.| | |..|.|| .|||. ..  || |.|.|..|  || . ||.|...|   | .|.||||||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK
|...||||. ....||.|||||||| ||||.||.|| .|. |. |..|||.  |  .||..  ||.||.|| ||....|||. ||.| .|.  . |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LAQVEPGEHVTGMELE
  ...|    . .. |
sirldpqtnssqlkee

subfamily_PTPRA_pd Subfamily PTPRA 1370-1684 2.9e-109 359.9 In-house 11-330 (330) alignment
Range on Protein: 1370-1684
Range on HMM: 11-330/330.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
..|.|. .. |  .. .|.|. .. .|....     | | | .. | || |||. |.. ||.|||||...||.  |||||| ..|||. .. .||.|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS----SEKREVRQFQFTAWPDHGVPEYP
 ||  |||||.|||.||||||.| |.|. . || ||||. |. ||| |.|.. |. .|  . || | ... .      ..| |||| ||.||| |||  |
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
   | .|..||..|.  |||||||||||||||| |||.||.|||.| |. |||.. |  .| ||  ||||. || ||...|||    |.||. . ||  .
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

IQKLAQVEPGEHVTGMELEF
.||| .  .| . .|.| ||
lqklynkitgtdkigleeef

0050432 (Phosphotyrosine protein) phosphatases II 1367-1651 2.3e-107 354.2 In-house 20-301 (308) alignment
Range on Protein: 1367-1651
Range on HMM: 20-301/308.0
MLSHPPIPIADMAEHTERlkANDSLKLSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVILqpieGiMGSDYINANYVDGY--RCQNAYIA
. |. .... |.... |.  |.|. .|..|.| .   .  .......|. ||.|||| ....||||||.|    .  |||||||.|||||  ......||
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIa

TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR---GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
||||||.|..|||||||||.. .|||.|.|.|..|.||.||||.    |...|| ..||||.. .|....|||. | ..|..| |.|..|..|.||||||
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

PEYPTPFLAFLRRVKTCNPPdaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
|..|...|.||..|....|.  |||||||||||||||.||..| .||... |..|||.. |  .|.||..||||..|| |...|||| . .
Ppspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

subfamily_PTPRB_pd Subfamily PTPRB 1371-1649 4.7e-107 352.4 In-house 5-285 (293) alignment
Range on Protein: 1371-1649
Range on HMM: 5-285/293.0
PPIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
 || . ...|| ...||.. |..|.|||..   |.. . . ..|.||. |||| |...|||||| |.....  |||||||||..||.... .||||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHGVPEYPTPFL
||. ||||||||..| .|||.|.| || ..||..|||.   . .|| |.|||. . ||  . .|.....|  ..|.|.|||..||.|||||||| ....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.|.|.|..      ...|||||||||||||| || .| .|..|. | .||..| |. .|..||..||||.|| |||...|. .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1377-1656 4.4e-105 346.2 In-house 13-297 (298) alignment
Range on Protein: 1377-1656
Range on HMM: 13-297/298.0
DMAEHTERLKANDSLKLSQEYESIDPGQQ----FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETF
 . . ..  |...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|. ...   |||||| ....|. .||.||||.||.||.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLR
 ||||||.|. ..||||.| |||. ..|. .|||..|.|||| |.|.|| . | | . ||.. ..|. ....|||||..|| |||.||||. |  |..||
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

RVKTcNPPDAG--PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
.|.. .. .||  |..|.|||||||.| ||.||..|||.| |..|||.  |  .| .|  .||||.||.||.|| |||. ..|.|.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0050432 (Phosphotyrosine protein) phosphatases II 1647-1945 1e-103 342.1 In-house 10-304 (308) alignment
Range on Protein: 1647-1945
Range on HMM: 10-304/308.0
EAVGCGNTEVPARSLYAYIQKLAQ-VEPGEHVTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGvEGSDYINASFIDGY-
|.. ...|.... ||. ....|.. .|.    ...| ||..| . |     . .|.||.|| ||| ..|.||...||.|    . |||||||||..||| 
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgys

-RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
 ......||||||| .|.||||||.||.|....|||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.||||..|.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.|.||..||| | | ..||. .|.|.     ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||.. |.|.|.|.||||
ytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

GSFDH
 .. .
klklt

0051299 (Phosphotyrosine protein) phosphatases II 1652-1940 2e-103 341.1 In-house 1-286 (288) alignment
Range on Protein: 1652-1940
Range on HMM: 1-286/288.0
GNTEVPARSLYAYIQKLAqvepGEHVTGMELEFKRLANSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI
|.||.....|. ...||       ..||.. ||..| . ...   . .|.||.|. ||| ..|.||...||.|... |||||||||||.||||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQ
|||||| .|.||||||.||.|....|||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.||||..|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||| | | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||.. |.|.|.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 1372-1647 9.3e-103 338.7 In-house 1-275 (278) alignment
Range on Protein: 1372-1647
Range on HMM: 1-275/278.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
||.. |.... ..|..|.  .|..|.|...  . .|.....|. ||.|||| ....||||||.|....| ..||||||.|||||......||||||||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPnRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
..||||||||... ||||.|.|.|..|.||.|||| .|..||| ..||||....|....|||. ....|..|.|.|.......|||||||| ....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
..|....... ||..|||||||||||.||... .||... |..||..  |  .|.||  .|||..|| |..|||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 1362-1654 1.4e-101 335.1 In-house 3-294 (297) alignment
Range on Protein: 1362-1654
Range on HMM: 3-294/297.0
FHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQfTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGI-MGSDYINANYVDGYRC-QN
. ....|...|||.  .. .  ..|||.. .| .|.|..   .   .....|..||.|||| ....||||||.|.|..|  ..||||||.|||||.. ..
plrdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTeTYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHG
..||||||||||..|||||||||.. .|||.|.|.|..| ||.||||..|. ||| ..||||....|. ..|||... .  ..| |.|..||.| |||||
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhg

VPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
||.... .| ||. |....   |. ||..|||||||||||.||... |||... |..|||.  |  .|.||...|||..|| |...|||| . ...|
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1652-1947 2e-101 334.2 In-house 1-297 (298) alignment
Range on Protein: 1652-1947
Range on HMM: 1-297/298.0
GNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKA--HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA
||||. |..| | .||||.|.. ...||..|||.|| . .   ..     |. | || |||  .|....|.|| |. . . | ||||||||...|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
.||||.|| ||.||||||..|.... .||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|.|||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
|.  .  .|.. .|.....| | . |. |.|||||||.| || .. ||||.. | |||.||.||.||..||..||||..| |.|.| ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1678-1944 3.8e-101 333.3 In-house 23-287 (319) alignment
Range on Protein: 1678-1944
Range on HMM: 23-287/319.0
TGMELEFKRLANSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
|..| ||| | ....    | ||. . || |||  ||..|. ||| |... ||||||||||||||||......||||.||..|.||||||.||..| |||
tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPI
||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.| .||.|.||...||... . .|......|..|.  |.|||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPi

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
 ||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||... |.|.|.| ||.. ..|
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0036941 (Phosphotyrosine protein) phosphatases II 1385-1663 4e-101 333.5 In-house 7-291 (297) alignment
Range on Protein: 1385-1663
Range on HMM: 7-291/297.0
LKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILqpiEGiMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR
 |.... .|..|.|...| . ........|. |..|||| ....|||.||.|   ..  |||||||.|||||......||||||||.|..|||||||||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SATIVMMTRLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIE--LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP
. .|||.|.|.|. |.||.||||.   .. ||| ..||||.. .  |.....||. . ..|..|.|.|..|..| ||||||||.|...|.|...|.....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

P--DAGPIVVHCSAGVGRTGCFIVIDAMLERIK---PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYA
   . ||..|||||||||.|.||..| ||....    |..||..  |  .|.||. .|||..|| |..||||| . ...| .|...|. 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl

0046845 (Phosphotyrosine protein) phosphatases II 1393-1654 4e-101 333.4 In-house 2-279 (284) alignment
Range on Protein: 1393-1654
Range on HMM: 2-279/284.0
LSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG-IMGSDYINANYVDGY-----RCQNAYIATQGPLPETFGDFWRMVWEQR
| .|.| .   . .   ......|. |. |||| ....||||||.|....| . .||||||.|||||     ......||||||||.|..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATIVMMTRLEEKSRIKCDQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--
. .|||.|.|.|..|.||.||||. | . ||| ..||||.. .  ...|||..| ..| ..| |.|..|..|.|||||||..|...|.||| |.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK---TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
|. |||||||||||||||.||..| .||... |.   .|||.. |  .|.||..||||..|| |..|||||.. ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0047943 (Phosphotyrosine protein) phosphatases II 1386-1648 1.9e-98 324.6 In-house 7-271 (273) alignment
Range on Protein: 1386-1648
Range on HMM: 7-271/273.0
KANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILqpieGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS
|.... .| .|.| . . . ..|.....|. || |||| ....||||||.|    |  |||||||.|||||......||||||||.|..|||||||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ATIVMMTRLEEKSRIKCDQYWPNRG---TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPP-
 .|||.|.|.|..|.||.||||. |   ..||| ..||||.. . ....|||. | ..|..|.|.|..|..| |||||||......| |.. |....   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 . ||.||||||||||||.||..| .|.... |..|||.  | |.|||| .||||..|| |..||||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0046845 (Phosphotyrosine protein) phosphatases II 1679-1943 2.3e-98 324.3 In-house 1-277 (284) alignment
Range on Protein: 1679-1943
Range on HMM: 1-277/284.0
GMELEFKRLANSKAHTS-RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDFWRMLWEN
|.| ||..| . . . .  .  |.||.|. ||| ..|.||...||.|... |  |.|||||||..|||     ...|..||||||| .|.||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
|....||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.||||..|..|.||..||| | | ...|. .|..  |.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG---VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
....||| |||||||||||.||.| ..||....||   .||....||.||.||| ||||.. |.|.|.|.|||| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0045450 (Phosphotyrosine protein) phosphatases II 1370-1648 8e-98 323.2 In-house 6-303 (307) alignment
Range on Protein: 1370-1648
Range on HMM: 6-303/307.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGI-MGSDYINANYV--------DGYRC
...|.. ..  .  .|....  .| .|.|.. . . |   ......|..||.|||| ....|||.||.|....|   .||||||.||        |||..
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKN-GSSEKREVRQFQFTAW
....||||||||||. |||||.|||.. .|||.|.|.|. |.||.||||. |.| ||| ..||||.. .|. ..|||. .. . |..| |.|..|..|.|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

PDHGVPEYPTPFLAFLRRVKTCNPP--DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
||||||... ..|.|...|....    . ||..|||||||||||.||... ||.... |.|   ||..  | |.|.||  .||...|| |..||||| 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0040438 (Phosphotyrosine protein) phosphatases II 1678-1940 1.8e-97 321.7 In-house 18-276 (317) alignment
Range on Protein: 1678-1940
Range on HMM: 18-276/317.0
TGMELEFKRLANSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
|... ||..| . | .   .  |.||.|| ||| ..|.||...||.|.|. |...|||||||..||.......||||||| .|.||||||.||...|..|
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
|||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..||||..|..|.||..|||.| . ..||. .|..  |  ...||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||||||||||.||.. ..||....|| ||....||.|| ||| .|||.. |.|.|.|.||||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0047943 (Phosphotyrosine protein) phosphatases II 1674-1940 9.2e-97 319.0 In-house 8-272 (273) alignment
Range on Protein: 1674-1940
Range on HMM: 8-272/273.0
GEHVTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS
  ..|....||..| . |     .  |.||.|| |||  .|.||...||.|    | .||||||||..|||......||||||| .|.||||||.||.|.
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TIVVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF
...||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.||||..|..|.||..||| | | ...|| .|.|. |..
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ..||. |||||||||||.||.| ..|.....|| ||....||.||.||| ||||.. |.|.|.|.||||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1379-1648 3.8e-96 316.5 In-house 9-278 (288) alignment
Range on Protein: 1379-1648
Range on HMM: 9-278/288.0
AEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWR
 ... . .|..   .|.||.|.   ... . . ..| ||..|||| |...||. || |.  |   |.|||||.|.||.. ...||||||||..| .|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-ETYGFIQVTLLDTIELATFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT
.|.|... ||||.| | |. . ||..|||. .. . || ..|||... ||  | .|.. |.|.   ...|. |.|..|||||||||  .|.|..|| ||.
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkv

CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 |. |.|||.||||||||||| ||..||...... |...|| | |. .| ||. .|||. || ||.|.||. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

0039614 (Phosphotyrosine protein) phosphatases II 1671-1943 1.5e-95 315.3 In-house 25-292 (297) alignment
Range on Protein: 1671-1943
Range on HMM: 25-292/297.0
VEPGEHVTGMELEFKRLANSKAHtsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRML
.|.    |...|||..| . |     .  |.||.|| ||| ..|.||...||.|.|..|| ..|||||||..|||.. ....||||||| ||.||||||.
lekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WENNSTIVVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE
||...|..|||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.||||..||.|.||. ||| | | ...|. .|..  .
weqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
. ...||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||.. |.|.|.|.||.|  .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0045450 (Phosphotyrosine protein) phosphatases II 1664-1940 4.3e-95 314.2 In-house 13-304 (307) alignment
Range on Protein: 1664-1940
Range on HMM: 13-304/307.0
YIQKLAQVEPGEHVTGMELEFKRLANSKAH-TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFI--------DGYRQQKAYIAT
.. .| .... ...||.. ||..| . . .    . .|.||.|| ||| ..|.||..|||.|... |  |.|||||||..        |||......|||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPK
|||| || |||||||||...|..||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.||||..|..|.||..|||.
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||... |.|.|.|.||.|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0036941 (Phosphotyrosine protein) phosphatases II 1677-1943 7.5e-95 312.9 In-house 12-280 (297) alignment
Range on Protein: 1677-1943
Range on HMM: 12-280/297.0
VTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 .... ||..| . ..    .  |.||.|. |||  .|.||..|||.|    . |||||||||..|||......||||||| .|.||||||.||.|.|..
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
||||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.||||..|..|.||. ||| | . ..||| .|.|  ... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPISVHCSAGVGRTGVFITLSIVLERMR---YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
.||. |||||||||.|.||.. ..|....   .|| |||...||.||.||| .|||.. |.|.|.| ||.| ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0043336 (Phosphotyrosine protein) phosphatases II 1677-1940 9.5e-95 312.5 In-house 19-277 (278) alignment
Range on Protein: 1677-1940
Range on HMM: 19-277/278.0
VTGMELEFKRLANSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 |...|||..| . |     .  |.||.|| ||| ..|.||...||.|... |...|||||||..|||......||||||| ||.||||||.||...|..
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPI
||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.||||.......||..||| | . ..||. .|..  |   ..||.
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpv

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 |||||||||||.||.| ..||....|| ||....||.||.||| .|||.. |.|.|.|.||||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

DSPc_SM00195 1393-1648 1.5e-94 311.5 In-house 2-261 (263) alignment
Range on Protein: 1393-1648
Range on HMM: 2-261/263.0
LSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|..|.|...  . . . .... . || |||| |.. |||.||.|...|.  |||||||||..|......|||||||||.|. ||||||||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIELA-TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
. ||. ..|||.|||.   |.||.| |.|.| ....    . .||..| |.| .|.|.|.|.|...|||||||. ....|..|| ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|||||||||.|..|| .|.... ||.||.   |. .|.||  ||||..||.||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 1393-1648 1.5e-94 311.5 In-house 2-261 (263) alignment
Range on Protein: 1393-1648
Range on HMM: 2-261/263.0
LSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|..|.|...  . . . .... . || |||| |.. |||.||.|...|.  |||||||||..|......|||||||||.|. ||||||||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIELA-TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
. ||. ..|||.|||.   |.||.| |.|.| ....    . .||..| |.| .|.|.|.|.|...|||||||. ....|..|| ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|||||||||.|..|| .|.... ||.||.   |. .|.||  ||||..||.||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_PTPRA_pd Subfamily PTPRA 1695-1939 1.6e-94 311.5 In-house 48-294 (330) alignment
Range on Protein: 1695-1939
Range on HMM: 48-294/330.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW
. .  |.   || |||.|||.||. .|| |....||| ||||||||||||.... .||.|||..|| ||||||.|| .|. .||||.|.|  .|||.|||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdgPISVHCSAGVGRTGVF
| | .  |    |    |  . .| .|.| |..     |. .|| |||| || ||. |||  . | .... .|.|...| ..  || ||||||||||| |
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtf

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
|.|. ||||.. |..||.|..|| ||.||| ||||.  |.|.|.. |||
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1372-1669 2.9e-94 310.6 In-house 3-303 (305) alignment
Range on Protein: 1372-1669
Range on HMM: 3-303/305.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGqQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
.| ..|.|.. .  ..... .| ..|.|.    . . .  . |.|| |||..... .|..|.||.. |    ||||||.|||||. ...||..||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFSLHK-NGSSEKREVRQFQFTAWPDHGVPEYPTPFL
  ||||...| .  ||||.|.| |  . || ||||.. ||   .| ..|.| .. . . .  | ... . ....|.| | |.|.| |||||||...| .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFLRRVKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK
 ...||.     | | |..||||||||||| ||..| .|||.| |..|||.. .  .||.| .|||| ||| |.|.|| | . ||.|..    | | ..|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LA
| 
lk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1369-1662 3.4e-93 307.0 In-house 2-291 (315) alignment
Range on Protein: 1369-1662
Range on HMM: 2-291/315.0
SHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
.| |||. ..  .  . ||.    . |.||||  || .  . ..   || |||| |.||||.||| |  .|   .|||.|||..|||  .. |||.|||.
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRgTETYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHGVPEYPTPFL
... .||||.|.|.  ..|||.| | |. . |...|||..   .|| | ||. .      ..|||.|      .. ||| |...|.||| |||.| .|..
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplm

AFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVpARSLY
 . |.||  .  ..|.||||||||||||| || .||.|.... |. .|||  .| .|..|  |||. .|| ||..||||.. ||.| . |. ||
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdly

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1415-1651 1.3e-92 304.6 In-house 8-244 (250) alignment
Range on Protein: 1415-1651
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIkCDQYWPNRGTETYG
 || |||||..||.|.|||.|.. .|   |||||| ...||. ..|.|||||||..|. ||||||.|. |.||||.| |.|. .  . ||||  ..|.||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK
 ..|.||.. | | . .|.. | |.  ...| |||..|..||| ||||. |  |..|..|.. ..  ...|..|.|||||||.|.||.|||.|||.| ||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
.|||.  .  .| .|  .|....||.|..|..|.|. .
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1371-1669 4.4e-92 303.8 In-house 14-311 (319) alignment
Range on Protein: 1371-1669
Range on HMM: 14-311/319.0
PPIPIADmAEHTERLKAND-SLKLSQEYESI--DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP
|..|.    . . . ...|   ||  |.  .   . .  . ...||. || |||. |..|.|...| |....|. .|||||| .|.||. .. |||.|||
pdfpayy.qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGP

LPETFGDFWRMVWEQRSATIVMMTrleeksRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTP
|..|  |||||.||....|||..|      . || ||||... ....  .| .    | | . || . | ..|   ..|...|| |  |||.|||.||..
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

FLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
.. ....|.  .    .  .||||||||||||| .||.|..|.|.| || ||||  |  .| ||| .||   || ||. ||||    |...|    . ||
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

IQKLA
...|.
leels

0040439 (Phosphotyrosine protein) phosphatases II 1407-1649 6.7e-92 302.8 In-house 2-246 (249) alignment
Range on Protein: 1407-1649
Range on HMM: 2-246/249.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP
......|..||.|||| ....||||||.|....|  .||||||.|.|||......||||||||||..|||||.||... .|||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDA
..|. .|| ..||||...... ..|||. |.... .|.|.|...|.| |||||||... ..|.|...|....   |. ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||... |..||..  | |.||||...||...|| |..||||| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

DSPc_SM00195 1682-1940 6.8e-92 302.9 In-house 4-262 (263) alignment
Range on Protein: 1682-1940
Range on HMM: 4-262/263.0
LEFKRLANSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||...|.|.|.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1682-1940 6.8e-92 302.9 In-house 4-262 (263) alignment
Range on Protein: 1682-1940
Range on HMM: 4-262/263.0
LEFKRLANSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||...|.|.|.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0042113 (Phosphotyrosine protein) phosphatases II 1409-1647 2.3e-91 300.8 In-house 2-241 (245) alignment
Range on Protein: 1409-1647
Range on HMM: 2-241/245.0
EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR
....|..||.|||| ....|||.||.|.|..| ..||||||.||||||. . .||||||||||..|||||.||... ||||.|..||..|.||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP-PDAGPIVVHCSAGVGRTGCFIVIDAMLE
.. ||| ..||||..  |....|||......|..|.|||...... |||||||...  .| ||..|...   .. ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
... |..|...  |  .||||  .|||..|| |..|||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1379-1649 7.9e-91 299.0 In-house 3-276 (281) alignment
Range on Protein: 1379-1649
Range on HMM: 3-276/281.0
AEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWR
 .|...|..||.  . .|||..   |.. | . |. . |. |||| |..|||..|| ..| |  . .||||||.|.||. ...|||||||.|... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLhKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT
|||||.  .|||.||  |....|| .|||.   . .|| ..|. . . | ||.  |.|.| .. |.|.|||.|...|||||||||. .. .| | . |. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

CNPPDA-GPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.. ..   |.|.||||||||||..| .| ...... | ...||   |. .| .||.||||  ||.|.. |.|.|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0045098 (Phosphotyrosine protein) phosphatases II 1394-1652 1e-90 299.1 In-house 11-275 (278) alignment
Range on Protein: 1394-1652
Range on HMM: 11-275/278.0
SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIlqpiegimgsDYINANYVDGYrcQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL
.. .. . .|.  ........ |..|||| ....||||||.          |||||.|.|||  ....||||||||.|. |||||.||... .|||.|.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN----GSSEKREVRQFQFTAWPDHGVPEYP--TPFLAFLRRVKTCNP--------
.|..|.||.||||..|..||| ..||||.. .| ....||. ..       . |.|.|...... |||||||..|  ..|| .|.... ..         
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----PDAGPIVVHCSAGVGRTGCFIVIDAMLERIkpEKTVDVYGHVTLMRSQRNY-MVQTEDQYSFIHEALLEAVGCG
     .. ||..|||||||||||...... |||..  |..||..  |. .||||.. .||...|| |..|.||| . .|
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

0040439 (Phosphotyrosine protein) phosphatases II 1698-1940 1e-90 299.0 In-house 4-246 (249) alignment
Range on Protein: 1698-1940
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||...||.|....|...|||||||.||||......||||||| ||.|||||||||...|..||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.||||...|.||||..|||.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|....|. ||....||.||.||| .||... |.|.|.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1407-1669 9.9e-90 295.9 In-house 16-275 (284) alignment
Range on Protein: 1407-1669
Range on HMM: 16-275/284.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTrleeksRIKCDQYWP
. ...||. || |||. ...|.|...| |... |. .|||||| .. ||. .. ||||||||..|  |||||.||....|||..|      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVID
... ....  .| .    | . . || . | ..|   ..|..||| |  |||.|||.||.........|.  .    .  .||||||||||||| .||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

AMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
..|.|.| || ||||  |  .| ||| .||   || ||. ||||    |...|    . ||...|.
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

subfamily_PTPRB_pd Subfamily PTPRB 1679-1940 2.3e-89 294.3 In-house 26-285 (293) alignment
Range on Protein: 1679-1940
Range on HMM: 26-285/293.0
GMELEFKRLANSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
..  |...| . . .     .|.|..|. |||  ||.||. .|| |..... .|||||||..|.||.... .||||||| ||..|||||.||..|.|.||
rfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS
||.| | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|.|||..|| ||. |||.. . ..||. .|....|.  ...|| 
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||||||||||.||.|  .|.... | .|||| .|  ||..|  .||||..| | .|. |..|
vhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

Y_phosphatase Protein-tyrosine phosphatase 1416-1647 1.2e-88 291.9 Pfam-A 1-235 (235) alignment
Range on Protein: 1416-1647
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILqpiEGIMG-SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTET
|| |||| ....||..|| |   .|  | |||||||||.||. ....|||||||..|..|||||||.... .|||.|.||||.| ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTI-ELATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI
|| |.|.|  ..  . . ...|...|.|.... |||||.|...|.|||||||| |...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
. |..|||.  |  .|.||. |||...|| |...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1416-1647 1.2e-88 291.9 In-house 1-235 (235) alignment
Range on Protein: 1416-1647
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILqpiEGIMG-SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTET
|| |||| ....||..|| |   .|  | |||||||||.||. ....|||||||..|..|||||||.... .|||.|.||||.| ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTI-ELATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI
|| |.|.|  ..  . . ...|...|.|.... |||||.|...|.|||||||| |...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
. |..|||.  |  .|.||. |||...|| |...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Ptp69D_pd Subfamily Ptp69D 1371-1669 1e-87 289.1 In-house 2-306 (307) alignment
Range on Protein: 1371-1669
Range on HMM: 2-306/307.0
PPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
..|.| |..|  .  | .    | .|||..     . . . |. . |. |||| ...|.|. ||.|..|.|   ||||||... ||. .. .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-----SSEKREVRQFQFTAWPDHGVPEYP
.| ||||||..|| . .|||.. |.||.| ||..|||.  .  || | |.| .. .   .  |.... |..       ..|.| |...|.|.|  ||| .
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
.  | ....|.  .  . .||||||||||||.| |. .| .|...| |..||..  |  .||||| .||  .||.|.. |||.    |.|..  ..|   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKLA
|..|.
ierlc

subfamily_PTPRG_pd Subfamily PTPRG 1678-1942 1.6e-87 289.0 In-house 19-289 (563) alignment
Range on Protein: 1678-1942
Range on HMM: 19-289/563.0
TGMELEFKRLANSKAHT-SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS-DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
.|.. ||. | .  ...     ... |.|| ||| .||..|...|| |.|. |.... |||||..||||...||.|||||||..|..|||||.||.|..|
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ..|||...|.||..|||..    . |. .  .....
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

fgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
  . ||| |||||||||||..| |. .|.... | .|..|...|..|.||. .||||..|.| ..| || . |
..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_PTPN9_pd Subfamily PTPN9 1665-1940 2.5e-87 287.7 In-house 3-290 (297) alignment
Range on Protein: 1665-1940
Range on HMM: 3-290/297.0
IQKLAQVEPGEHVTGMELEFKRLANSkAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
|..| .    ..  |.  |.. . |  . . .|  ..|..|  |||  ... |..||| |. . . | ||||||.|.|||.|.||.||||||| .|..||
ieelvayvkekgkrGlskeyaeirne.pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
|||.||..  ..|| |.. |.|| || ||||   | ||..  . |  .   .. .|  | ..........||.|  |||. ||. |||.|.. ..|.. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
| ... ..            .. || ||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||.. |.|||.| ||| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1677-1944 5.2e-87 286.8 In-house 21-287 (305) alignment
Range on Protein: 1677-1944
Range on HMM: 21-287/305.0
VTGMELEFKRLANSkaHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 .|.| ..| |..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .| .||||...|   . .
dkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQD
||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||| |.|.||||..|||..   ....| .|.|.... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
 |. ||||||||||||||...| |||.. |.|||.|. .| ||..|. |||| |.|.|...|  |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

0045098 (Phosphotyrosine protein) phosphatases II 1693-1941 1.6e-86 285.4 In-house 21-273 (278) alignment
Range on Protein: 1693-1941
Range on HMM: 21-273/278.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVClqpirgvegsDYINASFIDGYrqQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
. |..  |....|. ||| ..|.||...||.          ||||||.||||  .|..||||||| .|..||||||||...|..||||.| |.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQDGP
||| . | .|  |.|  . |.... |.|| ..||.      |..||.|...... ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ISVHCSAGVGRTGVFITLSIVLERMryEGVVDIFQTVKMLRTQRPA-MVQTEDEYQFCYQAALEYLG
. |||||||||||... . ..||..  ||.||....||.||.|||  .||... |.|.|...||.| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN9_pd Subfamily PTPN9 1385-1647 3.1e-86 284.1 In-house 10-288 (297) alignment
Range on Protein: 1385-1647
Range on HMM: 10-288/297.0
LKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR
.|...   ||.||. |     . | ..|.| .|  ||||..|. ||..|| |. ...   |||||||.||||. ..|.|||||||..|. |||||||||.
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

SATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----
  .|||.||..|. |.|| ||||  .  .. .|...|. ... |   . ||.. ...   .|.|.|  |||..|||.|||.  . .| .|. |.      
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala

---------NPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
          .|.  |||||||||.|||| || .|  |.|.. . ||||   | |.|.|| ...||..|| | . |.||
vkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0042113 (Phosphotyrosine protein) phosphatases II 1700-1940 4.1e-86 283.6 In-house 4-243 (245) alignment
Range on Protein: 1700-1940
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||..|||.|.|. | ..|||||||..||||. . .|||||||.||.|||||||||...|..||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.|.......||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
...|. |.....||.|| ||| .|||.. |.|.|.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1701-1947 1.7e-85 281.3 In-house 5-249 (250) alignment
Range on Protein: 1701-1947
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|....|.|| |.. .| . ||||||||..||...||.||||||| .|.||||||..|..|. .||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|.|||..|. ||..|||.  .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
. | |||.|. .|.||..|| .|.... | |.|...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1675-1939 3e-85 281.4 In-house 31-291 (319) alignment
Range on Protein: 1675-1939
Range on HMM: 31-291/319.0
EHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
...| .| ||.|...  .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .| .|||||.|| |..
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IVVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD
 .|.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | ..|| |  ||..|||...  .. .. .|.. ...  . 
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE-Y
 .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   .|.|.| | || .
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

Y_phosphatase Protein-tyrosine phosphatase 1705-1938 3.7e-84 277.2 Pfam-A 1-235 (235) alignment
Range on Protein: 1705-1938
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
... |. ||..|.||.||.||| |||....|.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1705-1938 3.7e-84 277.2 In-house 1-235 (235) alignment
Range on Protein: 1705-1938
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
... |. ||..|.||.||.||| |||....|.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1676-1937 1.1e-83 275.7 In-house 19-276 (288) alignment
Range on Protein: 1676-1937
Range on HMM: 19-276/288.0
HVTGMELEFKRLANSKAHTSRFIsANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
  ||.. |.. ||. . . |  . ..|. |. |||  ||.||. .|| |.    ..|.||||||.|||....|.|||||||||.| .|||.. .||... 
nrtgfseeynsLaalektksvta.grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

VVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDG
.||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ... |.|.. ||..|||.| . ..... ||. ....    |
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tg

PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
|| |||||||||||.||.|  ...... | ..|.. ||. || ||. .|||.  |.|.|.. |
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPRK_pd Subfamily PTPRK 1697-1938 2e-83 274.8 In-house 35-275 (314) alignment
Range on Protein: 1697-1938
Range on HMM: 35-275/314.0
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA
. .|.   |. |||  .|..|. .|| |..| |   ||||||..||.|.. .|.|.||||| ||..||||.....|.. .||||.| | || || .||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

ERSArYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFITLS
. .  |. . |  .      ... | |.|. .     . |.||||||. ||. .||.| .|..... .|.|..|.  ..|.| |||||| ||||.||...
dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaid

IVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
|||. .. |||||.|..|| ||.... ||.||. |.|.|...||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Ptp69D_pd Subfamily Ptp69D 1678-1940 2.4e-83 274.8 In-house 22-286 (307) alignment
Range on Protein: 1678-1940
Range on HMM: 22-286/307.0
TGMELEFKRLANSKAHTSRFiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
 |.. |...| ... . |    ..   |..|||  .|.....||| |..| | | ||||||||| ||...| .|| |.|. .| .|||||..| ..|..|
fglakeyekLeareidkstk.vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgq
||..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| | |...| |..  ||.. .| ...| ||.. ...   
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .|| |||||||||.|.|..|...|.... |  ||||.||| || ||. .||  . |.|.|.| |.| 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1681-1939 5.1e-83 273.8 In-house 1-255 (284) alignment
Range on Protein: 1681-1939
Range on HMM: 1-255/284.0
ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT
| ||.|...  . ..    |||. || |||...|.... ..| |... |.|.||||||||| ||.... |||||||| .| .|||||.|| |.. .|.||
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

klremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH
      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |..||| |  ||..|||...  .. .. .|.. ...  .  .| ||
......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE-Y
||||||||||.|.| ..|.||. |  ||....|. || ||. .||   .|.|.| | || .
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

subfamily_PTPN6_pd Subfamily PTPN6 1661-1940 5.3e-83 273.5 In-house 9-297 (306) alignment
Range on Protein: 1661-1940
Range on HMM: 9-297/306.0
LYAYIQKLAQVEPGEHVTGMELEFKRLANS--KAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGY--RQQKAYIATQGP
.   ...| . |   . .|.| ||..| ..  |   ||   .. | || |||  ||.|.. ||| |.   .| |||||||..|..    ..|.|||||| 
ieqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgc

LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGE
| .| .|||||.|..||...||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|.|.|..|..||..||||. .
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

GFIDFIGQVHKTKEQFG--QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ..||. .|.. .|..   . ||| ||||||.|||| || . |.|. ....|.   .|| ..||..|.||  .||||. |.| |.|  .|.
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_PTPN6_pd Subfamily PTPN6 1389-1647 9.7e-83 272.7 In-house 24-295 (306) alignment
Range on Protein: 1389-1647
Range on HMM: 24-295/306.0
DSLKLSQEYESI---DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPETFGDFWRMVWEQR
.   ...|.|..   .  .... ....   || |||| |.. .||.||||.  ....|||||||||...     ...|||||| |..|  |||||||.. 
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SATIVMMTRLEEKSRIKCDQYWPNRGT-ETYGFIQVTLLDTIELATFCVRTFSL-HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----
|  |||.|.  |... || .|||.  . |.|| |.|| ..  .||.. .|..|. .|. ..|.|||.|..|..|||||||. |  .|.||. |..     
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

NPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE---KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.  .|||||||||||.|||| |||||..|. |. .     .|..  | ..|.||. .||||.|| |...|. .
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

0037934 (Phosphotyrosine protein) phosphatases II 1408-1647 4.2e-81 267.3 In-house 2-240 (243) alignment
Range on Protein: 1408-1647
Range on HMM: 2-240/243.0
WEHSNLEVNKPKNRYANVIAYDHSRVILqpiEGimgSDYINANYVDGYRcqNaYIATQGPLPETFGD----FWRMVWEQRSATIVMMTRLEEKSRIKCDQ
. ...|..|..|||| ....||||||.|   ||   |||||||......  . .||||||||||. |    ||||.||... .|||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnrGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--------NPPDAGPIVVHCSAGVG
|||  |..||| ..||||.. .|. ..|||..|   . . ..|.|.......|||||||. |...|.||. |...        . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERIkpekTVDVYGHVTLMRSQRNY-MVQTEDQYSFIHEALLE
|||..|... ||...    .||..  | |.|.||.. .|||..|| |..|||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1372-1686 7.5e-81 266.4 In-house 2-314 (315) alignment
Range on Protein: 1372-1686
Range on HMM: 2-314/315.0
PIPIADMAEHTErlKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|||.|..    .  |   .  .|.|.  .   . .    .  ..| .|||| |.. .|..||.|. |. .  |||||| |. .. ...||||.||||. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFsLHKNgSSEKREVRQFQFTAWPDHGVPEYPTPFLA
  ||||||.... .||||.| ..|  .||| ||||.| ..   .| |.|.||..   .   .| .   .. | |.| | ||||| |||.||..  . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk.seesrtvtqfqftewPdkGvdkqtssllk

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
... ||. | ..  ...||||||||||| .| || ....|| ...|||.  |. .|..| |.||||..|.||..|.|| .   || ..   .  ..| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QVEPGEHVTGMELEFKR
    |.  . |  ||..
tsvdgsgrskmtkefet

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1372-1688 1e-79 263.0 In-house 1-315 (515) alignment
Range on Protein: 1372-1688
Range on HMM: 1-315/515.0
PIPIADMAEHTErlKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|.|.|..    .  |..    .|.|.  .   . .    .. |.| .|||| |.. || .||.|. |.    |||.|| |. .. ...||||.|||.. .
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPTPFLA
  ||||.|.... .||.|.|.|.|  .||| .|||.. ..   .| |.| |. .   .    |.. . |.     | | ||.|| |||.|||.  . .| 
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllk

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
... ||. .   . |...|||||||||| .| || .. ..|  ..|||.  || .| .| |.|||..||.||..|.|| .   || .|   .  ..| | 
likevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

QVEPGEHVTGMELEFKRLA
    |.  . |  ||. | 
ssgdgrgrskmtkefqtlk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1678-1946 1.3e-79 262.1 In-house 20-289 (290) alignment
Range on Protein: 1678-1946
Range on HMM: 20-289/290.0
TGMELEFKRLANSKAHTSrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
.|.. .||.| ... . .    .. . || .||  ||..|.  |. |.|| | .    .||||..|.||...|.|||||||. .|  |||...|....||
egfrnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvti

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDG
.||||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |....| |.|.| |...|  .  .. .  | .. ||. . | ..
ivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.nt

PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
.| ||||..|||..||... . ..... |||.|.|| .| .|.|.| .|||...||. .|  |.|| ||. |
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_PTPN12_pd Subfamily PTPN12 1392-1649 9.2e-79 259.3 In-house 16-277 (290) alignment
Range on Protein: 1392-1649
Range on HMM: 16-277/290.0
KLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|| .. |     .... |... |.|. |||| ... ||.||| |. ||.  ||||||||.. |   . .|||.|||||.|  |||||.||..   .||. 
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC

RLEEKSRIKCDQYWPNRGTET--YGFIQVTLLDTIELA-TFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
|. |  ..||..|||..| |.  .| ..||| .   .   | .||. ....  .|.|.|.||..|||||||||. ... |.... |.. .  .. |.|||
revelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh

CSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||||||||  |.|| . | .| ||.   .||.  |. .| ||. .|||..||.....|..| |
CsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_PTPN12_pd Subfamily PTPN12 1696-1940 2.9e-78 257.7 In-house 31-277 (290) alignment
Range on Protein: 1696-1940
Range on HMM: 31-277/290.0
RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP
.  ... . |. |||  .|.||. .|| |. |...||||||||.|| |  ....|||.||||..| .|||||.|| | .||||. .. |.|. ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

AE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
 |  .. ... | |. ..| ..  ....| .||.    ..||.|.||..|.||..|||.| .  ...| .|....|   .| |. |||||||||||. |.
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
. .| | .. | .   .|.|. |  ||.||.|.|||.. |.. |.| .|..
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

0037934 (Phosphotyrosine protein) phosphatases II 1699-1940 2.1e-77 255.2 In-house 4-242 (243) alignment
Range on Protein: 1699-1940
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYESTRVCLqpirgvEGSDYINASFIDGYRQqkaYIATQGPLAETTED----FWRMLWENNSTIVVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||..|.....   .||||||| ||.||    |||||||...|..||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQDGPISVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|.|...... ||..||| | | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDIFQTVKMLRTQRPA-MVQTEDEYQFCYQAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||.. |.|.|.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1373-1684 3.8e-77 254.6 In-house 5-323 (325) alignment
Range on Protein: 1373-1684
Range on HMM: 5-323/325.0
IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETF
| . .. || |. ||.|   ...|.. . . .  . . . .  || |||. ||.|.|.|||.|.  .    ||||||.|.  .. .. ..|.| ||..| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMVWEQRSATIVMMTRLEEKsRIKCDQYWPNR--GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF
.|.||.| . |.. .|..  |...   .| .|||..   . |.| ..| |    |.. .  | . . .    | | |.|||. .|.| ||...|. ....
ndlWrlvldWrcsvvvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKT------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
|. ||.      .|   ..||.||||||||||| || . ..|...  |  ||..| |  .| .|  ||.| |||..|.||| ||. .|||.||  |. | 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLAQVEPGEHVTGMELEF
.  | . .|  .   .| ||
lsslqernpltqklniekef

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1414-1648 8.4e-77 252.5 In-house 5-239 (239) alignment
Range on Protein: 1414-1648
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrGTET
 ||| ||||||...||||||.|. .     ||||||.|.  |    .||||||| .  . ||||||.|..| . |||.| | |  . || ||||.  |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsk

YGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE
|  ..|||  |  .| . .||| . . | .|.| | |..|| |||.|||.| |  | . |..   . | | | |.||||||||||.|.|||||| . | .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
||||.. .|  .| .| .|||| .|| ||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1413-1647 2.2e-76 251.1 In-house 5-239 (239) alignment
Range on Protein: 1413-1647
Range on HMM: 5-239/239.0
LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrGTE
  ||| ||||||...||||||.|. .     ||||||.|.  |    .||||||| .  . ||||||.|..| . |||.| | |  . || ||||.  | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.sts

TYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKP
 |  ..|||  |  .| . .||| . . | .|.| | |..|| |||.|||.| |  | . |..   . | | | |.||||||||||.|.|||||| . | 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.||||.. .|  .| .| .|||| .|| ||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1675-1940 3.3e-76 251.1 In-house 12-276 (281) alignment
Range on Protein: 1675-1940
Range on HMM: 12-276/281.0
EHVTGMELEFKRLANSK-AHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS
.. .|.  |.. ||.    .|..  ... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .. ..||.|.||.. 
ndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

TIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
...||.|.  | |. |||.||| .. . .|  ..|  .|| . ..|| |.||. ....|..|.|.|...| ||..|||.. . ...|  .|.|..|.  .
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

dGPISVHCSAGVGRTGVFITLSIVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
  |. .||||||||||..|.|  .....   .  .|. ..|. || .|  ||||   |.| |.| |..|
.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1373-1651 1.5e-75 248.8 In-house 2-285 (290) alignment
Range on Protein: 1373-1651
Range on HMM: 2-285/290.0
IPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLP
||. ...|...  .|.   .  ......| |. ..| .. . . ||..||.||.. ||  |..|.|| |      .|||| |..||. ...|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS-SEKREVRQFQFTAWPDHG-VPEYPTPF
.|  |||...|..... |||.|   |. . || ||||...|..|| ....||.  .| ..  |....... |  .|..| |.|.|.|...| |... |  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
|.. ...||   .  ..||||||..|||.. |....  ... | |  .||.  .  .|.|.  .|||..|| .|.. .|... .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1371-1659 2.1e-75 248.6 In-house 8-294 (297) alignment
Range on Protein: 1371-1659
Range on HMM: 8-294/297.0
PPIPIADMAEHTERLKANDslKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCqnAYIATQGPLPE
 |||..|.|   .. .  |    |.|.  .   . ..   ..  || .|.||.|.. || |||.|. ..    |||.|| .| |..    .|.|| | ..
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPE--YPTPFL
|  |||.||.... .||||.. ..|. . || .||...|. |.| . |.|| . |   |  |.... |. .  .| |.|.||. |||. |..    . .|
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

AFLRRVKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR
 ..  |.      |  |..|||.||||||| .. || .. ..| ||.||..| |. .| .| |.|||..||.|...|.|||. . .|...| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_PTPN3_pd Subfamily PTPN3 1406-1648 2.1e-75 248.2 In-house 31-274 (280) alignment
Range on Protein: 1406-1648
Range on HMM: 31-274/280.0
FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgiMgsDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC
 . .....  | .|||| ....||. ||.|.  |     ||||||||.    .    | ||||||||..|  |||.|||||.| .|||.| | |. |.||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI
 ||||. . . .|| ..|..  . |  ....| . |... ..|.|.. |.|..||||||||. .. || |..||...   .  |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
...  |  |  .. | .   |  || ||  .|||..|| |. ||.|..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN13_pd Subfamily PTPN13 1409-1649 3.1e-75 247.9 In-house 30-269 (273) alignment
Range on Protein: 1409-1649
Range on HMM: 30-269/273.0
EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGimgsdYINANYVDGYRCQN--AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP
| .. . || |||| ||. ||..||.|.   |     ||||...     ..   |||.|||||||  |||.|||||..  |.|.|   || ..||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

NRGTE---TYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPpDAGPIVVHCSAGVGRTGCFIVID
..  .    .. ..|.||.. .| .| ||.. .... |.| ||| ...|..|||||||  ....| |...|.. .  ||||||||||||.||.| .|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
..|. |. .| .||   |  .| ||. .|||.||| |...|.||..
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1704-1940 7.3e-74 243.7 In-house 42-276 (515) alignment
Range on Protein: 1704-1940
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||.|.|| |. |     |||.|||.| ..  .|||||.|||.  ...||||.....| | ..|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||| ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
   .||.|..|. .| .|| .|||...| | |.| ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1392-1647 1.7e-73 242.1 In-house 6-266 (274) alignment
Range on Protein: 1392-1647
Range on HMM: 6-266/274.0
KLSQEYESIdPgQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVM
.| .|. .. |   |. |. ..  .. |||| ...  ..|||.|.. ..    |.||||||. ||.  ..||.|||||||.|  |||||......  |||
dlekeflel.P.lnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP---PDA
.|.|.|. . || .|.|..     .|.|| ....  ...|   . ||...|..  .  .|.|  . .|.|||| .|. ....| ... |.. .      .
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.|.|||||||.||||||| |.  . ... |..||| . |. .| .|  ||||..|| .||.|| .
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1679-1947 2.9e-73 241.4 In-house 21-285 (287) alignment
Range on Protein: 1679-1947
Range on HMM: 21-285/287.0
GMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
| .  |. | . . .      .  . || |||| .|....  || |.     |  |||||.|||||...||.|....|...|  .||......| |..||
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivm

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPIS
|....|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ..|.|.|.|.|...|  .. .  .  | .  ||. . | ...| 
lcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
||||..|||...|.   . ... . |||.|.|| .|  | |.| .||| ..|.| ... |||| ||. |.
vhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_PTPN3_pd Subfamily PTPN3 1684-1937 1e-71 236.1 In-house 21-272 (280) alignment
Range on Protein: 1684-1937
Range on HMM: 21-272/280.0
FKRLANsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirGVEGsDYINASFI----DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|..|   |        |..| |  |||  .|.||..||| |.     |  |||||...    ..  . . |||||||||.|..|||.|.||..|...|||
feqlyr.kkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISV
| | | || ||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.. |.|...||..|||.. . |..|. .|.|...  |.. |. |
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvvv

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
|||||.|||||.|.| . |  .  .  | . . |...| || ..|||.. |.|  .| |
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1673-1940 1.6e-71 235.8 In-house 14-277 (315) alignment
Range on Protein: 1673-1940
Range on HMM: 14-277/315.0
PGEHVTGMELEFKRLANSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENN
   |.. .  ||. | . ..  .|  .|  . |  |||  ||.|..|.|| |. |     |||||||.| .. ..|||||.||||  . .|||||.....
knrhtalfseefhdlpdPdi..yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqek

STIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQf
 | .||.||..|  . || ||||     |...  . |. .      . . |.. ||  .  .|||| |||||.||..||.|    .. .| .|   ... 
vttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk.

gQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .. .. ||||||||||||.|..  |..... . .||.|..||.||..|| .||||.|| | |.| ||.|
.kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1377-1656 2.2e-71 235.6 In-house 6-286 (439) alignment
Range on Protein: 1377-1656
Range on HMM: 6-286/439.0
DMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFG
.. || |.|. |.   .....|.|.   |  .        | ...|||| .| |.||.||.|| | |.  | ||||||..||  .. |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQRSATIVMMTRLEEKSRikcdqYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG--SSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
||||.|.|....||||.| | |  .     |||  .   || | |     |||  ...| | . ..   .  .| | ||...||||. ||   .  | ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||. | |...| ||. |||.  || ||..|.|| .  |.. |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1413-1656 6.8e-71 233.6 In-house 44-285 (287) alignment
Range on Protein: 1413-1656
Range on HMM: 44-285/287.0
LEVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET
 . ||.|||..... .|  ||.|.        ||||| ..|||. ..|.|....|. .|  .||.......  .|||.....|. . .| ||||.  . .
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHG-VPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIK
.|  ...||.    | . .|.. ..... ...|..|.|.|.|.|...| |.|. | .| . ...||   .  ..||||||..|||.. |. ..  ... |
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
 | ..||.  .  .| |.  .||| .|| || ...|| . ...| .
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1701-1941 9.9e-71 233.0 In-house 24-269 (274) alignment
Range on Protein: 1701-1941
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .| ||.. .|||.||||||..| .|||||.........||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD-GPISVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|.|  . .||||.. .|.. . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG
|| . ..| |.|||....|  || .|  ||||.. |.. ..|  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1674-1944 3.3e-70 231.6 In-house 22-288 (297) alignment
Range on Protein: 1674-1944
Range on HMM: 22-288/297.0
GEHVTGMELEFKRLANSKahTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQqkAYIATQGPLAETTEDFWRMLWENNS
. |.. .. ||. | ...  .     |.   |  |.|  ||.||.| || |. .     |||.||||. |...   .|.|| |  .| .|||.|..... 
nrhtdvfseeflclpean..iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqv

TIVVMLTKLREMGReKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK--SGEGFIDFIGQVHKTKEQFG
...|||... |  . || .||. . .. . . .|  ..  .   .| ||..||  .  . | |.|.||..||.. |..  | . ....| .|.|. .|  
stivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna

QDgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
.  |. |||.||||||||..|.  |. ... |  ||||..||.|| .|| .|||...|.| |.| ||.| | |
eg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1416-1647 6.6e-70 230.0 In-house 3-237 (237) alignment
Range on Protein: 1416-1647
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVILQPIEGimGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG-TETY
|| ||||.|..|||||||.|.   .  |||||||.|..|.    . |||.||||  .  |||.|||... . |||.| | |. ..|| .|||.    ..|
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GFIQVTLLDTIELATFCVRTFSLHKNGS-SEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIK
| . |.|    |.. . ||.. | |...  | | . |.|||.|||.|||.. . .| | ...   .|  ...|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
 .| ||.| .|  .  .| |..||.||| |||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN1_pd Subfamily PTPN1 1403-1649 1.1e-69 229.4 In-house 19-271 (290) alignment
Range on Protein: 1403-1649
Range on HMM: 19-271/290.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGimgsDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD
 ..|. ....|. |...||| .|  |||||..|.  .     |||||. |.  . .  || ||||||.| . ||.|||||.| ..||. .. ||..||| 
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPNRGT-ETYG----FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT--CNPPDAGPIVVHCSAGVGR
||||.    ..       ..|.|. . .  .. ||.. |..  . | ||. .| .|.||| |||| |. || || .|.   .  .| || |.|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.| |...|..| .|. ..    ||.  ..  .|..|  ..|| ||  | . |.|| .
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

subfamily_PTPN13_pd Subfamily PTPN13 1683-1942 2e-69 228.9 In-house 16-271 (273) alignment
Range on Protein: 1683-1942
Range on HMM: 16-271/273.0
EFKRLANSKAHTSRFIsANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSdYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT
||| | . |.  .  . ..   || |||  |..||. ||| |.     ||. |||||.|      ..  |||.|||| ||..|||.|.|| ......|.|
efkelrelkpldtcev.gkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPIS
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| | ...|..||. |||.| . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|. || || ..|||.| | |.|.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_PTPN14_pd Subfamily PTPN14 1682-1940 1.6e-67 222.6 In-house 27-296 (300) alignment
Range on Protein: 1682-1940
Range on HMM: 27-296/300.0
LEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVeGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
 |. |... ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| |      ... ||..||||  | .|||.|.||.. ...|||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TKLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
|. .| |.||...|.| .    ...... | |      . ...| . .|.     .. |||  .|.||||..|||.  .||.... .|.  .... .   
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
    . |. |||||||||||| |.  .... .  . ..|| .....||.||  .|||   |.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_PTPN23_pd Subfamily PTPN23 1674-1939 2e-67 222.0 In-house 11-279 (288) alignment
Range on Protein: 1674-1939
Range on HMM: 11-279/288.0
GEHVTGMELEFKRLANSKAHTSRFISAN-LPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQ-KAYIATQGPLAETTEDFWRMLWEN
 . .|... .|| | ..... .|  |     ..  |||  .|.||...||.|.     .  |||||||. .   .   .||||.||..|  |||.|..|.
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

NSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK--TK
 | ..|||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ..|.  |.| ||| |||.| | ...|...|..  ..
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

EQFGQDGPISVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
.|   . |. |||||||||||||    ..| |  . .|..|| | |. ||.||  |||......|.|.| ||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1695-1941 2.2e-67 222.5 In-house 38-289 (325) alignment
Range on Protein: 1695-1941
Range on HMM: 38-289/325.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLrEMGREKCHQYW
  .  | .| || |||. |..... .||.|.  .    |||||||..  ..... ..|.| ||..|..|.||.. . ....||.| .| . | ..| .||
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavyw

PAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ----DGPISVHCSAGVGRTG
| |   | ..  . |  ..  ..  |. | ..| ....|..|.|.|||.  |.. ||.|    .| ..  |.. .|.        .|| |||||||||||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG
|||.|  .|...  |  ||||. || || .||.||.| |.| ..|.|  |.. 
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1685-1940 1.9e-66 218.8 In-house 2-264 (270) alignment
Range on Protein: 1685-1940
Range on HMM: 2-264/270.0
KRLANSKAHTSRFisANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR
|.| . ....| .   .   .|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. |...||||.||...| .||.|.| 
keldkeetsesdl..peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EMGREKCHQYWPAERSA--RYQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQD
| ||.|| .|||||.    ....    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . 
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.|. |||||||||||..|.| |... .  .. ||. . .. || .|.|.||. ..|.| |.| .|| 
ePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_CG7180_pd Subfamily CG7180 1705-1940 3.3e-66 218.0 In-house 42-290 (296) alignment
Range on Protein: 1705-1940
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||...|.. ..|.|| |..|  || ..|||.......  ||.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQDGPISVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |.|..||.| |.  . || | ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
... . || .. |. ||.|. ||.|| .|| .|.. .||...|.  ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1700-1940 3.4e-66 218.3 In-house 44-279 (315) alignment
Range on Protein: 1700-1940
Range on HMM: 44-279/315.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAErS
|.   || ||| .||..|. .|| |  .   ..|||.||.||||| ... |||.|||.... .||||...|.. . .||||.| |  ..|. .||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

ARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLER
  |  . |  . |    .|  | . |.   . . |.| |...| ||. ||||.   ....| .|.. ...    |.| ||||||||||| ||||. ||..
viyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.  | ..|... .. .| .|  |||. ..||| |.| || .
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1414-1663 4.1e-66 217.7 In-house 31-280 (283) alignment
Range on Protein: 1414-1663
Range on HMM: 31-280/283.0
EVNKPKNRYANVIAYDHSRVILQPIEGimgsDYINANYVD---GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
. ||.|||. .....|  || |..       ||||| ..     |. .. ||..|.|| .|  |||.||.... ..|||.|.| |  |||| ||||.||.
denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKR-EVRQFQFTAWPDHGvPEYPTPFLAFLRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLER
| ||   ||| .     .| .. . |..|.|...   .  .|.  | . | .. .   |  . .|..       ||||||||.|.|||. || . | .. 
edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkd

IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYA
.. |  |||.  |. || ||  .||| ||| ..||. ||   ||.|.. |  |..
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs

subfamily_CG7180_pd Subfamily CG7180 1415-1653 1.5e-64 212.5 In-house 41-294 (296) alignment
Range on Protein: 1415-1653
Range on HMM: 41-294/296.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTETYG
 |. |||. .|. ||. ||.|. ..|   |||||| |||..  ...|| |..|  || ..|||.|... . ..|..|.  . .. .. .||||.. | ||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyg

FIQVTLLDTIELATFCVRTFSLHKN----------GSSEKREVRQFQFTAWPD-HGVPEYPTPFLAFLRRVKTC-----NPPDAGPIVVHCSAGVGRTGC
 | | .. . ..| .  ||| | |.           . |.| |..||.| |.  . ||   . .. ..|||..      . |. ||.||..| |..|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGN
.. ||| || .. |. |||.. |  .| .|. .|.. ..| .| . ||||| |. 
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1372-1693 1.6e-64 212.7 In-house 3-280 (392) alignment
Range on Protein: 1372-1693
Range on HMM: 3-280/392.0
PIPIADMAEHTERlkANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|||.|..    |.     |  ...|.  .   . .    .. |.|..|||| |.. || .||.|. |. |  |||.|| |.... ...||||.||| . .
pipvaqfpafvek..nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FGDFWRMVWEQRSATIVMMTRLEEKSrikcdqywpnrgtetygfiqvtlldtielatfcvrtfslhknGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
. ||||||.... .||.|.|.|.|                                               ..| | ||.|| |||..||.. . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQV
. ||.     . |...||||||||||  | ||... . |  . |||.  || .| .| |||||..||.||. |.|| .   || .|   .  ..|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

EPGEHVTGMELEFKRLANSKAH
  |.  . .  ||. |  |.. 
sdGdvrskqlkefrslkashtv

subfamily_PTPRN_pd Subfamily PTPRN 1392-1649 3.4e-64 211.4 In-house 30-292 (297) alignment
Range on Protein: 1392-1649
Range on HMM: 30-292/297.0
KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYV-DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV
.|..|.|..     .. | | .. | |  |||...|..|||||| |.       ||||||  . |    . |||||||||..|  |||.||||| .. ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV
..|||||..  .|..|||. |.|.|.. .| |. . |    . ||.| |    .|| | | || | .||..|||  . ..| | |.|  .    . ||||
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||.|.||||..|.|| .|.|. |  | .|.   .  .| ||. .|.|.||. |.  |. | |
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1415-1647 2.7e-63 208.5 In-house 19-262 (270) alignment
Range on Protein: 1415-1647
Range on HMM: 19-262/270.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ-NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--
 .|  ||||...   ..||.|...|    . ||||||| |.  . ..|||..|||| |  .||||.||... .|||.| |||| | ||..|||..  |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--TYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPT------PFLAFLRRV-KTCNPPD-AGPIVVHCSAGVGRTGCFIV
  ..|.|.|. | .     . ..   |...|.  .|..  |....|||||||. .         |. || | ....  | |.|..|||||||||||..|.
kledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.| ... .. .| |||   .. .| .|  .||. .|| |...|..|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_PTPN23_pd Subfamily PTPN23 1414-1649 3.4e-63 208.2 In-house 41-280 (288) alignment
Range on Protein: 1414-1649
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQ-NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG--T
...  |||. ... |||.|| |.        ||||| .| .   .   .||||.||..| .|||.||.||.| .|||..  ||. . |.|.|||..   |
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----NPPDAGPIVVHCSAGVGRTGCFIVIDAML
...| ..||| .. |. |.  |...|. ........|.  |.|.||..|||. |  .|.||  |...    . .   |.|||||||||||| | .. | .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ERIKPEK-TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
. .. ..  .|.   |  .| || .|||...|. |  || |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1403-1646 7.5e-63 207.0 In-house 25-274 (287) alignment
Range on Protein: 1403-1646
Range on HMM: 25-274/287.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD
.  .|.  ..   .  |||||.|. .|..||.|   || .|||||||||| .|. ..|.||.|||.. | .||||.|.|.|||....|||  |..| || 
sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPNRGTE-TYGFIQVTLLD-TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV-----KTCNPPDAGPIVVHCSAGVGR
.|||.|      |   |.||| .|    ..||.. | .  . | | |.|... .|||....     .. |   |      . .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
.| .. . ....| .    |||   |  .| .|. .||.  |. .. ||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1675-1946 8.5e-63 206.8 In-house 12-299 (301) alignment
Range on Protein: 1675-1946
Range on HMM: 12-299/301.0
EHVTGMELEFKRLANSKAHTSRfISANlPCNKFKNRLVNIMPYESTRVCLQPIRG--VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENN
 | ...| ..|.| . . ...  .. .   ||  ||  || .|.  |. |.| .   .   .|||||.||||...|..||.|||. .|  ||||..|.. 
khsnkfeeqykelkegedksct.vgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

STIVVMLTKLREMGREKCHQYWPAERSARY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTVRQFQFTDWPEQGVPKSGEG
 . .||.|.|.|  ..||.||||  .  ..    | |  . |...|....|...|.  |              .| .|..| |.| ||||..|| .    
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

FIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
 .  | .| ... . |  ||. ||||..|.|.||....|| ||  . |||||.|| .| .| ..| .|.| . | . |..  .||   . |
vLqviddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_PTPN14_pd Subfamily PTPN14 1392-1647 8.5e-62 203.8 In-house 24-294 (300) alignment
Range on Protein: 1392-1647
Range on HMM: 24-294/300.0
KLSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGImGSDYINANYVDGYR--CQNAYIATQGPLPETFGDFWRMVWEQRSATIV
|. .||| | . ..  . . ..|..|..|||. .|. |...|| |.| .    ..||||  .       .  ||..||||. |  |||.|||||  . ||
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MMTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN------
|.|. ||. . |. .|.|. .    | ..|  .||   . .  ..  ... |.   |.|.|.|  .|.| |||||||| ...|| .|..|.         
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

-P--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
 .      |..|||||||||||  |. | ... .. ....|.   .. .| || ..|||  || |....|..
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPRN_pd Subfamily PTPRN 1680-1938 1.1e-61 203.1 In-house 31-290 (297) alignment
Range on Protein: 1680-1938
Range on HMM: 31-290/297.0
MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI-DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
.| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.| |   .. ||||||||||.|  |||.|.||. ....|.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||| || |  |||.||| |   ...|  .| |.    |.  || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCSAGVGRTGVFITLSIVLERMRyEG--VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
||||.|.|||||.| . .||.|.   |   .||  |.. || ||| .|.|.|...|...|  |
vhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1705-1940 8.5e-61 200.7 In-house 48-279 (439) alignment
Range on Protein: 1705-1940
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| .|.|| ..| |||||||  |||.||||...|.... .||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||| ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|  |||   ||.|| ||  |||.  .| | |.| || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1385-1654 4.3e-60 198.0 In-house 9-298 (301) alignment
Range on Protein: 1385-1654
Range on HMM: 9-298/301.0
LKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ
  |. | |....|.... |.. . . .  | ||. ||. |.  ||. |.||.| .   ..  .||||.|.|||. ....||.|||. .|  ||||..|..
vaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

RSATIVMMTRLEEKSRIKCDQYWPNRG--TETYGFIQVTLLDTIELATFCVRTFSLH-KNGSS--------------EKREVRQFQFTAWPDHGV-PEYP
. ..|||.| |.|... || |||||    .|..|...||| ..  .  | .| .... ..||.              . ..| |.| | ||..|| .|. 
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
|   .    ... . .. ||.|||||..|.|.| .. ..  ||  | |  |||.. .  .| ..  .|.| .||..|.... . . . .|
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1700-1939 7.6e-60 197.2 In-house 28-265 (283) alignment
Range on Protein: 1700-1939
Range on HMM: 28-265/283.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFID---GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA
|    || |||  .|.|..  || |..       |||||.||     |.|.| ||..|.|| .|  |||.|..... | .||||||.|  |.|| |||| 
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQDGPISVHCSAGVGRTGVFITLSI
. |  |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..| 
rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasa

VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
 .. .. | |||.|..||..| ||. .||| | |.. ....|| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1680-1939 3.3e-59 195.0 In-house 12-276 (287) alignment
Range on Protein: 1680-1939
Range on HMM: 12-276/287.0
MELEFKRLA-NSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
.. |...|  .|.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| |  ||||...|..|. |..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LTKLREMGREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV--HK-TKEQFGQD
.|.  | .| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| |.|... .||..... .  |.| |. .|  |   . .  . 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
||. ||...|.||.|..... ....|.   | ||. ..|  || .| |.||.   ... |.|   |
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_PTPN1_pd Subfamily PTPN1 1691-1938 3.3e-59 195.0 In-house 18-269 (290) alignment
Range on Protein: 1691-1938
Range on HMM: 18-269/290.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC
.|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||..|.. ||.|.||..|  |||| |. | .. ||
easdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

HQYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG
.|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.. .| .| ||. |||.|   |..|. .| ..     . ||  .|||||.|
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
|.| |. .  .| ..  ..    ||| ...  || .|  ..|| |  .| |.| ||
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

0051429 (Phosphotyrosine protein) phosphatases II 1444-1669 1.8e-57 190.3 In-house 4-244 (272) alignment
Range on Protein: 1444-1669
Range on HMM: 4-244/272.0
SDYINANYVDGYRC---QNAYIATQGPLPETFGDFWRMvWEQRSATIVMMTRLEEKSRIKCDQYWP------------NRGTETYGFIQVTLLDTIELAT
|.||||..|.||      .......|||| |  ||||. .|..  |||.....||. | |||.|||               | .||.. |||| .. |  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FCVRTFSLHKN-GSSEKREVRQFQFTAWPDHGVPEYPtpFLAFLRRVKTcnppdAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD--------VYG
. .|.. |..  . .| |||.....|.|||||||. .  .|..|. . .      ||..||||||..|||...... .|...  |  ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

HVTLMRSQRNYMVQTEDQYSFIHEALLEAvGCGNTEVPARSLYAYIQKLA
 |  .|.|| ..||||.|| |..|||||.  .. ..|.|. | |... . 
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1705-1938 1e-56 186.9 In-house 3-237 (237) alignment
Range on Protein: 1705-1938
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYESTRVCLQPIRGveGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||....|.    | |||.||||  . .|||.|.|... ...|||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | . |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
 . ||||.. |. .  .|| ..||.|.| | .|. ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0051429 (Phosphotyrosine protein) phosphatases II 1731-1942 1.3e-56 187.5 In-house 2-227 (272) alignment
Range on Protein: 1731-1942
Range on HMM: 2-227/272.0
EGSDYINASFIDGYRQ---QKAYIATQGPLAETTEDFWRMlWENNSTIVVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  | .||||. .|.. . .|.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPKSGegFIDFIGQVHKtkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.|.....||||  |||..   ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
 ....|..|| |||..||||. |.|.|.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1698-1940 1.5e-56 186.5 In-house 38-236 (392) alignment
Range on Protein: 1698-1940
Range on HMM: 38-236/392.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGrekchqywpae
 .|. . |. |||  ||.||.|.|| |. |  .  |||.|||.|... ..|||||.||| | . .|||||....| | ..|.|||.|             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

rsaryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktKEQFGQDG-PISVHCSAGVGRTGVFITLSIV
                               .  . ||| ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |
...............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsv

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
. . .   .||.|. |  .| .|| ||||...| | | | || |
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

0041856 (Phosphotyrosine protein) phosphatases II 1416-1656 1.7e-56 186.0 In-house 1-178 (182) alignment
Range on Protein: 1416-1656
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRvilqpiegimGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTrleeksrikCDQYWPnrgtetygf
|..|||| ... |||||          ..||||||...|.. .. .|||||||..|. ||.||..|..  |||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iqvtlldtielatfcvrtfslhkngSSEKREVRQFQFTAWPDHGVPEyPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVIDAMLERikpekTV
                         . ..|.. |.... |||||||. .  .|.|...|.     . ||..|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
...  | |.||.|. ||.|..|| |.. |||| . ...|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1704-1938 1.3e-55 183.1 In-house 6-238 (239) alignment
Range on Protein: 1704-1938
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|..   ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
.  ||||. || .| .|| |||| ..| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1704-1938 1.8e-55 182.7 In-house 7-239 (239) alignment
Range on Protein: 1704-1938
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|..   ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
.  ||||. || .| .|| |||| ..| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle

0036282 (Phosphotyrosine protein) phosphatases II 1443-1643 1e-53 176.9 In-house 1-164 (174) alignment
Range on Protein: 1443-1643
Range on HMM: 1-164/174.0
GSDYINANYVDGYRCQNAYIATQGPLPetfgdFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgtetygfiqvtlldtielatfcvrtfslhkNGSS
|||||||...|.... . .||.||||.     ||.|..|... |.||.....|. . || .|||                                . ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKREVRQFQFTAWPDHGVPEYPTpFLAFLRRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKpEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
..|.. |.... |||||||. .. .| |...|...    . ||..|||||||||||...... || ... |..||.. .|  .|.|| .||||..|| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HE
..
yy

0036282 (Phosphotyrosine protein) phosphatases II 1732-1934 1.5e-52 173.1 In-house 1-164 (174) alignment
Range on Protein: 1732-1934
Range on HMM: 1-164/174.0
GSDYINASFIDGYRQQKAYIATQGPLAettedFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||..|...  . .||.|||||     ||.||.|...|.||||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTVRQFQFTDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRyEGVVDIFQTVKMLRTQRPAMVQTEDEYQF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..||....|..||.||| ||||.. |.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYQ
.|.
lyy

0041856 (Phosphotyrosine protein) phosphatases II 1705-1940 2.1e-52 172.7 In-house 1-171 (182) alignment
Range on Protein: 1705-1940
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYESTRvclqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| .|..||.|||.|.. |..|.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTVRQFQFTDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 |.....||..| .|| ||.|.. |.|...|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell

0043147 (Phosphotyrosine protein) phosphatases II 1443-1643 7.2e-49 161.1 In-house 4-155 (172) alignment
Range on Protein: 1443-1643
Range on HMM: 4-155/172.0
GSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLeeksrikcdqywpnrgtetygfiqvtlldtielatfcvrtfslHKNGSS
|||||||.|.|.|.. . .|||||||..|. |||||..|.   .||..|.|                                            .... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

EKREVRQFQFTAWPDHGVPeYPTPFLAFLRRVKT-CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLerikpeKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
..|.. |.... |||||||  .  .| ||. ... ..  . ||..|||||||||||...... ||      . ....  | |.|..|...||...|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

HE
..
yy

0049772 (Phosphotyrosine protein) phosphatases II 1679-1941 2.7e-48 160.7 In-house 20-281 (314) alignment
Range on Protein: 1679-1941
Range on HMM: 20-281/314.0
GMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEsTRVCLqPIRGVEGSDYINASFIDGYrqqKAYIATQGPLAETTEDF----------WRML
...|...|.  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .| .||          ||| 
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WENNSTIVVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTVRQFQFTDWP
  ...|. ..||                     |..| . |      ...|.. . ..                    .... ..  .|.. ..  ...|
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvp

EQGVPkSGEGFIDFIGQVHKTkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERMryeGVvDIFQTVKMLRTQRP-----AMVQTEDEYQFCYQAALEYL
  ..| . | | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. ......| .||      .... ..|.|...| ||||
Dgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

G
 
k

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1402-1647 8.2e-48 157.5 In-house 42-281 (290) alignment
Range on Protein: 1402-1647
Range on HMM: 42-281/290.0
PGQQFtwEHSNLEVNK--PKNRYANVIAYDHSRVILQpiEGIMGsDYINANYVDGYRcqNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI
|.|..  | . .. |    |||| .|.  | .||||.  .|  | ||. ||||.| .    .| |||.| .|  |.|||| ... |.|||.  | |. . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPNRGTETYGFIQVTLLDTIE---LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCnppdAGPIVVHCSAGVGRT
||.||.|..  |.  | ..|.| . |    |    .|.|. .  |  .  .. ..  .|||. |.     .|  || ...     .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
| |. |.. |. .   | .|. . |  .|  |   || . ||  . |.||.
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_ptpA1_pd Subfamily ptpA1 1412-1608 9.7e-48 157.9 In-house 43-255 (418) alignment
Range on Protein: 1412-1608
Range on HMM: 43-255/418.0
NLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCqNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR---
. . |  ||||.|..  .|.|| |. |.   |||||||||.||    . .|.||||||.|  ||||||||.|   |||..|  |. |||||.|||..   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

--------GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----NP--PDAGPIVVHCSAGVG
        | | .|   | |.. |.     . |  ..     | |.. |.|.  |||| .|..  ||  .|. .        |      ||.||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGCFIVIDAMLER
||| |     |...
rtgtfctavimmkk

0046846 (Phosphotyrosine protein) phosphatases II 1435-1647 3.7e-47 155.6 In-house 3-171 (176) alignment
Range on Protein: 1435-1647
Range on HMM: 3-171/176.0
LQPIEGIMGSDYINANYVDGYRcqnaYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgTETYGFiqvtlldtielatfcvrtf
|...   ...||||||...|.|    .||||||||.|. ||..|..|..  ..|..| . |..|.||..|||    |..|.                   
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi...................

slhkngssekrevrQFQFTAWPDHGVPEYpTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLErikpEKTVDVYGHVTLMRSQRN-YMVQ
              |.... |||||||.. . .| .|. ....   . ||..||||||.||||...... .      || ..|.  . |.|.||  ..||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TEDQYSFIHEALLE
|..|| |..|..|.
tpeQyrflyefell

0049772 (Phosphotyrosine protein) phosphatases II 1406-1649 4.5e-47 156.6 In-house 36-280 (314) alignment
Range on Protein: 1406-1649
Range on HMM: 36-280/314.0
FTWEHSNLEVNKPKNRYANVIAYDhSRVILqPIEGIMGSDYINANYVDGYrcqNAYIATQGPLPETFGDF----------WRMV--WEQRSATIVM----
.|.  ..|..|. |||| ... .| .|||| | ... |||||||.||||.   ...|||||||..|. ||          ||||  ..... .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTRLEEKSrikcdqywP--------NRGtetygfiqvtlldtielatfcvrtfSLHKNGSSEKREVRQFQFTAWPDHGVPeYP
                  ..| ..         .        .                           . . ...  .|.. ..  . .||...|  .
vladelsrLdaAlgKtpllildgng........neptaadlellk.........................eelydpelferlgikylripvpDgsap.ll

TPFLAFLRRVKTCnpPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKpektVDVYGHVTLMRSQRN-----YMVQTEDQYSFIHEALLEAV
  |..||. ....  .. ||..|||.||.||||.|.|.. .. . .    |..   .  .|..|       .... .|| ||.|||||..
edfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1691-1938 6e-47 154.9 In-house 19-293 (297) alignment
Range on Protein: 1691-1938
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE
.|..  | ||. .    |||  .|. ...||| |.  |.. ..||||| ..      ..  || .|||| .| .|||....|..  ..||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| ||  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   ...|| ||. .||| ......|.|.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

0043147 (Phosphotyrosine protein) phosphatases II 1731-1935 7.9e-46 151.2 In-house 3-156 (172) alignment
Range on Protein: 1731-1935
Range on HMM: 3-156/172.0
EGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||..|.|.  . .||||||| .|..||||||.|.. |..|.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTVRQFQFTDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQDGPISVHCSAGVGRTGVFITLSIVLERMryegvvDIFQTVKMLRTQRPAMVQTEDEYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||... |.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FCYQA
|.|. 
flyyf

0046846 (Phosphotyrosine protein) phosphatases II 1724-1941 1.3e-45 150.6 In-house 3-174 (176) alignment
Range on Protein: 1724-1941
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFIDGYRqqkaYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||..|.|.|    .||||||| .|..||..||.|.. |.||.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtvrQFQFTDWPEQGVPKSgEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFITLSivleRMRYEGVVDIFQTVKMLRTQRP-AM
              |.....||. ||| . | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDEYQFCYQAALEYLG
|||.. |.|.|...|..|.
vqtpeQyrflyefellllk

0049260 (Phosphotyrosine protein) phosphatases II 1451-1643 2e-45 149.5 In-house 1-144 (152) alignment
Range on Protein: 1451-1643
Range on HMM: 1-144/152.0
YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWpnrgtetygfiqvtlldtielatfcvrtfslhkngssekrevrQF
..|||. ....||||||.|.|. |||||..|.   ||||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLerikpeKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
... |||||||. .  .| .|. .. ..  . ||..|||||||||||...... ||      . |...  | |.|..|...|....|. |..|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1411-1647 2.1e-45 150.1 In-house 36-275 (307) alignment
Range on Protein: 1411-1647
Range on HMM: 36-275/307.0
SNLEVNKPKNRYANVIAYDHSRVILQpIEGImGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
  .. |  |||| .| . |..|.... ..|.  |||| |||.      . .|..|||| .|  .|| |. ...  ...|. .. | ..|||.||||    
eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

ETYGF------IQVTLLDTIELA--TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVI
..  |      | |. | . .||    ..   .|. . ... | ....|.. |||.|||.     . .|  |.     |  |.||||||||||.|  . |
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivai

DAMLER-IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
  . .. |. .   |.   |  .||||.| .||| || ..|  |||
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1411-1647 2.9e-44 146.1 In-house 28-257 (267) alignment
Range on Protein: 1411-1647
Range on HMM: 28-257/267.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEgimgSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsRIkcDQYWPNRGT
|  | |. .||. ... ||..||||.  |     .|||| ||.||. .||.|.||.||  | .||. .. .|. ..||..|.  .   |   ..|| .  
siaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmg

ETYGFIQVTLLDTIE--LATFCVRTFSLHKNGSSeKREVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNppDAGPIVVHCSAGVGRTGCFIVIDAMLE
..  . ..|.  ..|     . . |. |. .  |  ..|  . .  |        |  |... | . .  |     |.||.||.||||.| |.|||..||
qakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqle

RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
|.| | ..|..  .  .||||  .|.| ..| .||| | |
raktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1683-1939 3.9e-43 142.4 In-house 11-258 (267) alignment
Range on Protein: 1683-1939
Range on HMM: 11-258/267.0
E---FKRLANSKAHTSRFISANlpcNKFKNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|    |.... ..  | .|. .   |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  |  ||. .. ... ...|.|
efelikkisdtsstisqsiaek...nqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYI--LREFKVtdaRDGQSRTVRQFQFTDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqDGP
||    . .. ...|| .  .. .|| ..|.   | .  .|     |.|.   ..  .. |  . .  |  .   |    .  ..| . | . . | . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrP

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
. |.||.||||.| |...   |||.. |||.|||. .. .| ||...|.| ..| ....   ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0049260 (Phosphotyrosine protein) phosphatases II 1740-1934 2.6e-42 139.4 In-house 1-144 (152) alignment
Range on Protein: 1740-1934
Range on HMM: 1-144/152.0
FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtvrQF
|||||......||||||. .|..||||||.|.. |..||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQDGPISVHCSAGVGRTGVFITLSIVLermryeGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
... ||  |||.. . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|...|..|| .|.... ..|.|.
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1679-1940 2.8e-41 136.5 In-house 17-277 (307) alignment
Range on Protein: 1679-1940
Range on HMM: 17-277/307.0
GMELEFKRLANSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVeGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
 .  ||. ||. . ..       . .|  |||  ..   . .|. .. . |.  |||| | ..    . | .|..|||| .|  .|| |  ...   |.|
alvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqf
| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..|||....|...||..|||.   . |...  |.      
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......

GQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
..  |. |||||||||.|  ...|.| ..| . .   |. . |. ||.||.  .||| .| . ..  |||.
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1393-1660 5.7e-41 135.1 In-house 29-300 (310) alignment
Range on Protein: 1393-1660
Range on HMM: 29-300/310.0
LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR
| ..|  .|  |. .  .   . .  ||||..|.  | ||| |. |.     ||| ||||     ....| .||||  |  |||||....|. .|... .
lvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

LEEKSRIKCDQYWPNRG-TETYGFIQVTLL----DTIELATFCV----RTFSLHKN-GSSEKREVRQFQFTAWPDHGVPEYPTPFLAflRRVKTcnPPDA
  |. | ||  |||  | ||||| |.|| |    . .|.  ..|        . ..    ..  |   ..  ||| |||.     .   .|. .      
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrlla..qvrh

GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLeAVGCGNTEVPARS
|| |||||||..|... . ..  .....  . ||.   .| .. .|   .||| || .|.   . .   |.|||  . 
gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaeki

0044763 (Phosphotyrosine protein) phosphatases II 1428-1647 4.2e-40 132.6 In-house 2-169 (178) alignment
Range on Protein: 1428-1647
Range on HMM: 2-169/178.0
YDHSRVILQPIEGIMGSDYINANYVDGYrcqnAYIATQGPlpetfGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTetygfiqvtlldtiela
.|..||.|...||. .||||||......     |.....|      |......|.   .||..|   |  ..|||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tfcvrtfslhkngssekrevRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERikpekTVDVYGHVTLMRSQ
                     |.... .||||||. .  ||.|.. .... ... ||..|||||||||.|...... |...      ....  . |.|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYSFIHEALLE
|. .|....|. ...|  |.
Rp.ivpnpgqlrqLyefelr

subfamily_ptpA1_pd Subfamily ptpA1 1693-1900 9.8e-40 131.5 In-house 35-256 (418) alignment
Range on Protein: 1693-1900
Range on HMM: 35-256/418.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRqQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
  |     .   |  |||  ||.| . ||| |. |.  |||||||| .|||    | .|.||||| .|  |||||.|||   |.|||..  |  | || .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPAERSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF----GQDGPI
||| .     |. .       .  |     .. |   ||        . .|..| . |.|.  ||.. .|   . | ...  . . ..|      .. ||
ywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

SVHCSAGVGRTGVFITLSIVLERM
 ||||||||||| | |  |.....
ivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1402-1647 1.1e-39 130.9 In-house 41-287 (305) alignment
Range on Protein: 1402-1647
Range on HMM: 41-287/305.0
PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgimGSDYINANYVDGYR-CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
  |.        .... ||||..| . |.| | |.       |||| ||||      .. .|..|||| .|  .|| || ...   |||. .  |  ..|
mtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

CDQYWPNRGTETYGFIQVTLLDTIELA-------TFCVRTFSLHKNGsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGV
| ||||    |   .    ... .  .          . .. |  .| ..|  ||..|.| ||| |||      | .|  ..  .     |||||||||.
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagi

GRTGCFIVIDAMLERIKPEKTVDV-YGHVTLMRSQRNYMVQTEDQYSFIHEALLE
||||  . |. .||.|  .| .      |  .| || . .|.. || |||  .|.
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

0051082 (Phosphotyrosine protein) phosphatases II 1732-1936 1.3e-39 130.5 In-house 2-149 (151) alignment
Range on Protein: 1732-1936
Range on HMM: 2-149/151.0
GSDYINASFIDGYrqqkaYIATQGPlaetTEDFWRMLWENNSTIVVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . .|.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryegvVDIFQTVKMLRTQRPAMVQTEDEYQF
  ..|......|||..|.| | . ...|. .. .      ..||. ||||||.||||... | ..|..      |.........| .|| .||......|
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYQAA
...| 
qlfal

0051082 (Phosphotyrosine protein) phosphatases II 1443-1646 3e-39 129.3 In-house 2-150 (151) alignment
Range on Protein: 1443-1646
Range on HMM: 2-150/151.0
GSDYINANYVDGYrcqnaYIATQGPLPetfgDFWRMVWEQRSATIVMMTRLEEKSriKCDQYWPNRGtetygfiqvtlldtielatfcvrtfslhkngss
 |||||..||.|.     .....|||.    ||.....|.   |||... .||    .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnpPDAGPIVVHCSAGVGRTGCFIVIDAMLERikpektVDVYGHVTLMRSQRNYMVQTEDQYSFIH
  .||...... |||.|.|...  .|.||. .     .. ||..||||||.||||...... ||..      |...  .  .|..| ..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EALL
 |||
fall

0044763 (Phosphotyrosine protein) phosphatases II 1716-1940 6.2e-39 128.8 In-house 1-171 (178) alignment
Range on Protein: 1716-1940
Range on HMM: 1-171/178.0
PYESTRVCLQPIRGVEGSDYINASFIDGYrqqkAYIATQGPlaettEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||.|...     |.....|     .|....|.|.. | .|.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtvRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryeGVvDIFQTVKML
                      |.... .|  ||| . | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... ....
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDEYQFCYQAALEYL
| .|| .|.... ....|. .|..|
rerRp.ivpnpgqlrqLyefelrll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1411-1647 8.4e-38 124.6 In-house 32-267 (281) alignment
Range on Protein: 1411-1647
Range on HMM: 32-267/281.0
SNLEVNKPKNRYANVIAYDHSRVILQP-IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG
 |  ||. ||||.|. . | ||| |.  .     .||| |||.     .  || ||||  ||  |||||.|.. ...|||. .. |  | || .|.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCnppdAGPIVVHCSAGVGRTGCFIVIDAMLERI
     | ....          . |  |      | | . .. .  |||  |||    .|  ||....     . | |.||||||||.| .. ..  |. |
hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqsi

KPEKTV-DVYGHVTLMR-SQRNYMVQTEDQYSFIHEALLE
.   |. |.   |. .| . |   ||| .|| .| . ||.
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1416-1647 1.2e-37 124.3 In-house 48-285 (305) alignment
Range on Protein: 1416-1647
Range on HMM: 48-285/305.0
NKPKNRYANVIAYDHSRVILqpiEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF
.. |||| .|   |. || |   ||    .|| ||||      . .| || || .|  ||| | ....  .| |.  | ||   || .|.. .  ..  |
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

I------QVTLLDTIE-----LATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKtcnpPDAGPIVVHCSAGVGRTGCFIVID
       .| .  . .      |   |.   |  .|.  ..| | .. .  ||| |||   .  | .| . .    |  ||||||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmle

AMLERIKPEKTVDVYGH-VTLMRSQRNYMVQTEDQYSFIHEALLE
 .|...   . ..   . .  .| |||  .||..|| |.|. .|.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1412-1648 1.8e-37 123.8 In-house 31-269 (285) alignment
Range on Protein: 1412-1648
Range on HMM: 31-269/285.0
NLEVNKPKNRYANVIAYDHSRVILQPIEgimgSDYINANYVD-GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
  | |   ||||.| . . .||.|.  .     ||| |...    . |..||.||||||||. |||.|..... | ..|.  | |    ||  |.|..  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

ET--YGFIQVTLLDTIELATFC----VRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDA
|   .|  ..|| .  | |         |    .. |||   . . |   |||.  ||   |.. . . ||  || .  ||.||||||||||  |. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidy

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
   ||  .  ...   |  ||. |   ||.  |. |..  |.| 
atirimenpniemldivremramrfqavqshmqflflyvvlmey

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1699-1939 2e-37 123.4 In-house 31-268 (281) alignment
Range on Protein: 1699-1939
Range on HMM: 31-268/281.0
SANLPCNKFKNRLVNIMPYESTRVCLQP-IRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
  | | |. ||| .||   . .|| |.  .   . .||| | .|     .. || ||||  ||  |||||.|..|.| .||| .. |  |||| .|.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSIVL
  .  |.  .    |    .  |   ..  . .|..| . .. . .||.  ||.| | ..  . ...       .  |  .||||||||.| .... | |
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveial

ERMRY-EGVVDIFQTVKMLR-TQRPAMVQTEDEYQFCYQAALEY
. ..    . || | |  || | | | ||| ..| . ..  |..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

PTPc_DSPc_SM00012 1835-1938 2e-37 123.0 In-house 1-105 (105) alignment
Range on Protein: 1835-1938
Range on HMM: 1-105/105.0
TVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCY
||.....|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . |||||.||.||.||| |||||..|.|.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QAALE
.| ||
ralle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1707-1943 6.9e-36 118.4 In-house 58-286 (290) alignment
Range on Protein: 1707-1943
Range on HMM: 58-286/290.0
FKNRLVNIMPYESTRVCLQpiRGVEGsDYINASFIDGYRqqKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|..|. |.|||. ... . .||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |..|   ..  .  . |.       ||. ||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
  .|. ..|. ||  | . || . .|    .. |..  .|
keldlldlvralrnsrlnsvqvdiqylalveilldlGkdf

PTPc_DSPc_SM00012 1547-1647 7e-36 118.0 In-house 2-105 (105) alignment
Range on Protein: 1547-1647
Range on HMM: 2-105/105.0
VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA--GPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
|.....|.||||||||.....| .|| ||...   .  .|.||||||||||||.|...| .|.... | |.||..  |  .|.||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_CG42327_pd Subfamily CG42327 1416-1576 2.9e-33 109.9 In-house 28-192 (319) alignment
Range on Protein: 1416-1576
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYR-CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR----GT
 |.|.|..||.   ..||.|| |     . |..|.|| ||. ..| |||.| .| ..  ||||.||||.| .|| .| | |.   .| .|.| .    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFtAWPDHGVPEYPTPFLAFLRRVKT
..|| |.||| .      . . |. |..   .| ||.  . .  |.. .||  .....| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1414-1563 3.1e-33 109.9 In-house 31-182 (297) alignment
Range on Protein: 1414-1563
Range on HMM: 31-182/297.0
EVNKPKNRYANVIAYDHSRVILQpiEGIMGSDYINANYVDG--YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-
.    |||| ...|.| .|| |.   .| ..|||||.||       .  || .|||| .|  |||..|.||   .|||...|.|  | ||  |||.    
nsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

-ETYGFIQVTLLDTI--ELATFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEY
  . | . |  | .   |  .  .  . |     ||.| ||  || .|||||||  
rlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1705-1940 3.7e-33 109.4 In-house 55-289 (305) alignment
Range on Protein: 1705-1940
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGY-RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   . . | |.       |||| | ..      .| .|..|||| .| ..|| |. .|.   .||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqfGQDGPISVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. .||..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||..  .  .  . . || || ||   .|.. .| | ..  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1736-1928 6.7e-32 105.4 In-house 78-269 (301) alignment
Range on Protein: 1736-1928
Range on HMM: 78-269/301.0
INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | .|.   . . .||||||| .|.|||| ||   .   .|||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDE
 ..|||  .|...|...|||||     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||.  
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1416-1648 6.8e-31 102.4 In-house 43-270 (288) alignment
Range on Protein: 1416-1648
Range on HMM: 43-270/288.0
NKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF
|  ..|| |.   | .|| |.         ||.|| |   . ..  | .| ||  | . .|.|. |.    |||...| || . | ..|.| .  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

IQ---VTLLDTIELAT-FCVRTFSLHKNGSsEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGVGRTGCFIVIDAMLERIKP
 .   |.  .  ..     | ..  .|.|  ||  |..  .  |.|.||||   ..| .| ..|...     |||||.|||||||| .|.|  .|| .. 
grlctvvkkkradidklvkvsllriskege.ekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
.  . .   .. .| .|   .||| || ..|  .|| 
ddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1705-1940 1e-30 101.7 In-house 35-270 (285) alignment
Range on Protein: 1705-1940
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYESTRVCLQPirgvEGSDYINASFID-GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| ||  |||.|..... . |.||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
  |.  .  ..... |. .|. |   ||.  .. | |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1688-1940 1.3e-30 101.4 In-house 26-271 (288) alignment
Range on Protein: 1688-1940
Range on HMM: 26-271/288.0
ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR
 .|  ..|  |  .   |  ..|  |.   . ||| |.     .   ||.|  .   . ..  | .| ||  | | .|.|| |..   .|||..| | |.
rdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk

EKCHQYWPAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGV
||  .|.| .   .||.. .  .   ...  . ...   .   . |. .  |..  . .|...|||..   .. ..  .         . || ||.||||
eksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGv

GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||| .|   |.|| .| .  . | . .. || .|   .|||  | . ..  ||.|
Grtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1705-1940 1.7e-30 100.8 In-house 48-287 (305) alignment
Range on Protein: 1705-1940
Range on HMM: 48-287/305.0
NKFKNRLVNIMPYESTRVCLQPirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY
.. |||  ..   .  || |..       .|| | ..    . | .| || || .|  ||| | ....   . || .| | | .||..|....     ..
eagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

F------VVDPMAEYNMP------QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFIT
       .|   .  ..         . .   | .   ...| | .. . |||..||| .    .... .   .|      ||| ||||||.||||  . 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvm

LSIVLERMRYEGVVD-IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|  .|...    ...   . .. .| ||   .||...| | .|  |.|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_egg_pd Subfamily egg 1407-1646 4.5e-30 99.4 In-house 31-267 (307) alignment
Range on Protein: 1407-1646
Range on HMM: 31-267/307.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrIKCDQYWP
. ...  . |. | |   |   | ||| |.  .|    |.| ||.|.|    | .| .| || .|  ||||||....   |||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

NRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFtAWPDHGvpEYPTPFlAFLRRVKTCnppdAGPIVVHCSAGVGRTGCFIV
.  ...  .    .... |.  . |    |   |.  |   |.| .  .|   .   .  .  .|.   ||...      . |.||..  || ...... 
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvyspl.rvlrklrnl....skpvvvqdilGvskaatlva

IDAML-ERIK-PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
|.  | . .. |     |   | ..| .|.. |..  .| |..  .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1446-1639 1.7e-29 97.5 In-house 77-271 (301) alignment
Range on Protein: 1446-1639
Range on HMM: 77-271/301.0
YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHK-NG
 | ||...     . .|||||||..|  ||| |.      .|||...  ||   ||..| | . .|.       |...  ..|       ||. ..   |
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS
  . | |  .|.. |.|.|||.  .    ..  ||  .     |||||||||.||. .||  . .  ... ..|...   .  .| .|   |||. |  
kfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

0048076 (Phosphotyrosine protein) phosphatases II 1519-1646 2.6e-29 97.1 In-house 18-140 (145) alignment
Range on Protein: 1519-1646
Range on HMM: 18-140/145.0
TLLDTIELATFCVRT-FSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLErikpeKTVDV
| ||  .|. . ..| ..|  . . ..|.. |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.     . |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

YGHVTLMRSQRNYMVQTEDQYSFIHEALL
.  . |.|||| ..|....|. |..|..|
eealelvrsqrpgavpnpgqlrflyefel

subfamily_CG42327_pd Subfamily CG42327 1703-1867 1.2e-28 94.7 In-house 26-194 (319) alignment
Range on Protein: 1703-1867
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK-AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| ... ||||..||..| ..| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFtDWPEQGVPKSGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .|| . . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1745-1934 5.4e-28 92.5 In-house 2-198 (199) alignment
Range on Protein: 1745-1934
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQ
. |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . . |.| ||
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1746-1934 7.1e-28 92.1 In-house 2-197 (198) alignment
Range on Protein: 1746-1934
Range on HMM: 2-197/198.0
QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQF
 |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . . |.| ||
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

0048179 (Phosphotyrosine protein) phosphatases II 1530-1643 8.7e-28 92.2 In-house 32-139 (144) alignment
Range on Protein: 1530-1643
Range on HMM: 32-139/144.0
CVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLerikpEKTVDVYGHVTLMRSQRN
.| ... .    ...||. |.... |||||||.... .|.||. .... ... ||..|||||||||||...... |.     .. ....  . |.||.| 
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

YMVQTEDQYSFIHE
..|....|. |..|
gavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1543-1687 3.2e-27 90.0 In-house 87-232 (440) alignment
Range on Protein: 1543-1687
Range on HMM: 87-232/440.0
EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
| | ..|... .|||.|||..  | | ... |. ..     ||..||||||.||||  |..|..|   |    .|..  .  ||..|  |||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL
|||.||.. ||.| .    .   ....   .|    . .. ||.  
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegy

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1417-1648 8.8e-26 85.3 In-house 44-275 (312) alignment
Range on Protein: 1417-1648
Range on HMM: 44-275/312.0
KPKNRYANVIAYDHSRVILQPIEGImgsdYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgteTYGFI
|  ||| |.  .|  |  |   | .    || ||.|      . ...||||| .|   ||...    |..|.... . | .  || .|  .      ||.
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfv

QV-------TLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVIDA
..            ||.          | . .  . . ..  . ..|...|||||.|.     | .|  ||     |  |.. |||||||||| ...|..
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalies

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|.  ..  .  .|     |.| .|   |..  || .   ..|| 
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1704-1933 3.7e-25 83.1 In-house 51-283 (310) alignment
Range on Protein: 1704-1933
Range on HMM: 51-283/310.0
CNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARY
 .  |||  ...  ...|| |. |      ||| | ..     ....| .||||  |  |||||.... .  ...| |  | || ||  |||.   .  |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

QYFVVDPMAEYNMpQYILREFKVTDA-----RDGQS-----RTVRQFQFTDWPEQGVPKSGegfIDFIGQVHKTkeQfGQDGPISVHCSAGVGRTGVFIT
    |  ..|    .. . .. ||        | |        |   .. .||..|||         . |   .  |  . ||  ||||||..|..| ..
gcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvva

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY
| . .....    ||. . .  |. .|   .||| .| .  
lklkidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_egg_pd Subfamily egg 1675-1937 6.3e-25 82.5 In-house 11-267 (307) alignment
Range on Protein: 1675-1937
Range on HMM: 11-267/307.0
EHVTGMELEFKRLANSKAHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
| | ..|  .. | .|  . |   .|.   |. | |   .   .|.|| |.  ||    |.| |  ..|      .| .| || .| .|||||.....  
eivqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevq

IVVMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtvRQFQFTDWPEQGVPKSGEGFIDFigQVHKTKEQ
 .||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .|.. .  .  .| .   .
yivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrn

FGQdgPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
  .  |. |..  || ........ | |  .    .    . ..|..|| .|.  |..   | | |.  |
lsk..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1708-1796 1e-24 81.9 In-house 50-152 (350) alignment
Range on Protein: 1708-1796
Range on HMM: 50-152/350.0
KNRLVNIMPYESTRVCLQ----P----IRGVEGSDYINASFIDGY----RQQKA--YIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY
||| .||.||| .|| |.    .       ....|||||...       ...    |||||.|| .| .||.... .|. .....||.. |...|||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPA
|. 
Wqe

0048076 (Phosphotyrosine protein) phosphatases II 1825-1939 1.7e-24 81.5 In-house 36-142 (145) alignment
Range on Protein: 1825-1939
Range on HMM: 36-142/145.0
VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQ
.|. ... .|.. |.....||  ||| . | ...|. ....  ..   .||. |||||||||||...    ..  |...| |.........|.||| .|.
ltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavp

TEDEYQFCYQAALEY
... ..|.|.. ||.
npgqlrflyefelel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1418-1512 1.8e-24 81.1 In-house 49-157 (350) alignment
Range on Protein: 1418-1512
Range on HMM: 49-157/350.0
PKNRYANVIAYDHSRVILQ----PIEG----IMGSDYINANYVDGY----RC--QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQ
 |||| |.. |.||||.|.    . ..    . ..|||||||.       .   .  |||||.|||.|. ||.... .     |...| . |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNRGTET
||.. . . 
YWqegsydd

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1456-1642 1.1e-23 78.4 In-house 2-197 (199) alignment
Range on Protein: 1456-1642
Range on HMM: 2-197/199.0
RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQ
. |  ||||| || ||. |||.||||  |  |||.   . .       |||    ||  || . ||       . ... .. | .| .     ||. ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTAWPDHGVPEYPTpFLAF---LRRV-KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT--VDVYGHVTLMRSQRNYMVQTEDQYSFIH
||.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
ftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1457-1642 1.6e-23 77.9 In-house 2-196 (198) alignment
Range on Protein: 1457-1642
Range on HMM: 2-196/198.0
CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQF
 |  ||||| || ||. |||.||||  |  |||.   . .       |||    ||  || . ||       . ... .. | .| .     ||. ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPEYPTpFLAF---LRRV-KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT--VDVYGHVTLMRSQRNYMVQTEDQYSFIH
|.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1832-1941 1.3e-22 74.7 In-house 87-195 (440) alignment
Range on Protein: 1832-1941
Range on HMM: 87-195/440.0
QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|||  .. .| .|| |||| ..| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYQAALEYLG
 ..| || | 
vheavlegll

0048179 (Phosphotyrosine protein) phosphatases II 1821-1934 1.8e-22 75.1 In-house 48-139 (144) alignment
Range on Protein: 1821-1934
Range on HMM: 48-139/144.0
RefkvtdardgqsrtVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEGvVDIFQTVKMLRTQRP
               . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||||.....     .|...| ..........|..||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQTEDEYQFCYQ
 .|.... ..|...
gavpnpgqlrfLle

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1708-1946 2.6e-22 73.9 In-house 46-282 (312) alignment
Range on Protein: 1708-1946
Range on HMM: 46-282/312.0
KNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| .|.  ||..     || ...|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| | .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
.|.    .. ..  .|| .|   |..  .| .. .. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1471-1649 5.5e-21 69.8 In-house 40-221 (255) alignment
Range on Protein: 1471-1649
Range on HMM: 40-221/255.0
TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS--EKREVRQFQFTAWPDHGVPEYPTPFL
|   |....  ... ..||.. ..|... ||..|.|    |   . .|..  |   |   .||  .  . .   . ..|. .... |...  || .   |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

AFLRRVKtcnppDAGPIVVHCSAGVGRTGCFIVIDAM----LERIKPEKTVDV--YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
  |. |.     |. ..|||||.|.||.  |.... .    .  ..  .||..     .. .||.|.  ..|  | .|    .|. |
nilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1585-1652 1.3e-20 67.5 In-house 1-68 (69) alignment
Range on Protein: 1585-1652
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCG
.|||||.| |||| || |   . ||| || ||..  |  ||  |  ||  | .| |||.|| ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1586-1652 2.1e-20 66.8 In-house 1-67 (69) alignment
Range on Protein: 1586-1652
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCG
|||||.| |||| || |   . ||| || ||..  |  ||  |  ||  |..| |||.|| ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1415-1645 1.2e-19 65.6 In-house 18-255 (290) alignment
Range on Protein: 1415-1645
Range on HMM: 18-255/290.0
VNKPKNRYANVIAyDHSRVILQPIEGIMGSDYINANYVDgYRCQNAYIATQGPLPET-------FGDFWRMVWEQRSATIVMMTRLEEKSRI----KCDQ
 .. ..|... ..  ..||.|.     . .||| ||.|  .    . |.|| |. ..         .|| |. . ..  .||.   ||||.      | .
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPNRGTETY--GFIQVTLLDTIELATFCVRTFSLHKNgSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKtCNppdAGPIVVHCSAGVGRTGCFIV
| |..  |    . ..|   . ..   . .|.  .. .   |.  |   ..  | .  |.| .  .|. .. || ..     |..|||  |. |  ..  
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaa

IDAMLERIK-PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL
|.     |   .. | .   .  .|.||. ..... ...|.  ..
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1415-1649 2.1e-19 64.3 In-house 46-279 (303) alignment
Range on Protein: 1415-1649
Range on HMM: 46-279/303.0
VNKPKNRYANVIAYDHSRVILQpiegimGSDYINANYVDgYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-E--
 |  |||...||  |||.| |        | || |.|..   ...  | || ||. |  |||.|. ||.   ....    |  ..  |  .|.       
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

TYGFIQVTLLDTIELATFC-VRTFSLhKNGSsEKREVRQFQFTAWPDHGVPEYPTP-FLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTGCFIVIDAMLE
   .|.|  .  .||.    ..  |.  ||.  |  .   .. |||   .|   .| |.  . ....   .  |. | |    .|.||.| | ....   
eersirvgefkrvelgdgwvlkvlsv.sngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
 . . . ..|.   .  .|  | . ||   |.|...  | | |
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

I-set Immunoglobulin I-set domain 33-124 4.5e-19 60.0 Pfam-A 1-90 (90) alignment
Range on Protein: 33-124
Range on HMM: 1-90/90.0
PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDEsAGAVLRIQPLrTPRDENVYECVAQNSVGEITVHAKLTV
|.| ...||.    |  ... |...|.|.|.|.| |.|....|..  .....| | . |.|.   ...||  |.|.|.||.|. . .|.|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnv.evsDeGkYtckatnsagkaeakaeLkV

fn3 Fibronectin type III domain 527-604 2e-18 59.5 Pfam-A 2-83 (85) alignment
Range on Protein: 527-604
Range on HMM: 2-83/85.0
QPMNLRAEARSETSITLSWSPPR--QESIIKYELLFREGDHGR-EVGRTFDPTT-SYVVEDLKPNTEYAFRLAARSPQGLGA
.| ||.......||.|||||||.  .. | .||. .|| ..|. .. .| ..|| |.....|||.||| ||..|.. .| | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1467-1641 2.2e-18 60.7 In-house 99-280 (302) alignment
Range on Protein: 1467-1641
Range on HMM: 99-280/302.0
PLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLlDTI----ELA------TFCVRTFSLHKN--GSSEKREVRQFQFTA
|  .|   .| .. . . | .| .. . |.   || .|. ..  ..  | . |.  |.    .|.      .| . |  .. .   .  |. |  ..|.|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytv.ktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYPTPFLAFLRrvkTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
||||| |. . . |  |.    |.      ..||||||||||| .. |   ..  . .|. |.   |. .|. |   ||.|.|  ..
wpdhGapkeaytaldilk...fcesyk.knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1678-1939 4.2e-18 59.8 In-house 26-284 (302) alignment
Range on Protein: 1678-1939
Range on HMM: 26-284/302.0
TGMELEFKRLANSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETT---EDFWRMLWENNST
. .. |||.... |... .        |  ||.  ..  ..|..| |.     |  .|.||| ..    ..  | .| |  ...   |.|||| .... .
aevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IVVMLTKLREMGReKCHQYWP--AERSARYQYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQ
 ||.| .  |. .   ....|  ..    |. . |     |.   .    .. .    .| | .|      .| |... ||..    |  . .|   ...
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakk

FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
   | .. .    |.|| |.|.|| ...|..  .  . | ..|| .|.|||..|.. . | . | |.| |
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1760-1938 1.3e-17 58.7 In-house 40-219 (255) alignment
Range on Protein: 1760-1938
Range on HMM: 40-219/255.0
TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFI
| . |....  .... ||||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .||. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
  .  |...|       .. ||||.|.||.  |.   .|  .|    .    . .|  . .. || .|.. ..|  .  |.    |.
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

subfamily_eak_pd Subfamily eak 1422-1575 1.4e-17 58.1 In-house 57-208 (332) alignment
Range on Protein: 1422-1575
Range on HMM: 57-208/332.0
YANVIAYDHSRVILQPIEgIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG--TETYGFIQVT
  ... ||.  | | .        ||||  ..     . || |  .  .    ||.|| ||.| .||..    |.   | |.|.|...     .|...|.
vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

LLDTIELATFCVRTFSLHKnGsSEKREVRQFQFTAWPDHGVPEYpTPFLAFLRRVK
  . .. . . .| . |.| |  |  .|  ...  | .  .| |   |||. . .|
rkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpky.edflalrkvmk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1389-1646 5.7e-17 56.1 In-house 24-282 (302) alignment
Range on Protein: 1389-1646
Range on HMM: 24-282/302.0
DSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETF---GDFWRMVWEQRSA
|. .. .|...||  .  . . .    |  ||.  .| ..|. .|.|.        .|.||  |.   ...  | .| |  ..     .|||||.... .
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

TIVMMTRLEEKSRiKCDQYWPNR-G-TETYGFIQVTLLDtIELATFCVR--TFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD
..|.. . || ..   ....|.. |  ..|| . |     .| |   .   .  .  .| |.   .    .| |... ||.  .   .    | . . . 
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkika

AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
  ..|.    |.|| | |..  . .|... .| . .   |. .||||  .|.. .|| ... |||
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

fn3 Fibronectin type III domain 621-708 7.4e-17 54.5 Pfam-A 2-85 (85) alignment
Range on Protein: 621-708
Range on HMM: 2-85/85.0
PPQDVKCVSVRSTAILVSWRPPPpeTHNGALVGYSVRYRPLGSEDpEPKEVNgIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES
.|..... .|.|| . .|| ||.  . .| ..||.|.||. |... |.||.. .|.|||.  |. |.  |.|...  |....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.ewkeft.vprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1708-1934 7.9e-17 56.3 In-house 22-253 (290) alignment
Range on Protein: 1708-1934
Range on HMM: 22-253/290.0
KNRLVNIMpYESTRVCLQPIRGVEGSDYINASFIDgYRQQKAYIATQGPLAET-------TEDFWRMLWENNSTIVVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |....        |.|| |  . ... |||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  ||   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
.    .   .| | . . .|.|| ||  ..... |. |   
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

fn3 Fibronectin type III domain 334-414 9.6e-17 54.1 Pfam-A 2-85 (85) alignment
Range on Protein: 334-414
Range on HMM: 2-85/85.0
APGTPMVTENTATSITITWDSG--NPDPVSYYVIEYKSKSQDG-PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPS
||. . |.|.|.||.|..|.    . .|...| .||..|.. . . ... . |||.. . || |..|||..| |||  |.||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1877-1940 1.5e-16 54.5 In-house 2-65 (69) alignment
Range on Protein: 1877-1940
Range on HMM: 2-65/69.0
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  | || | . |  | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1878-1940 1.6e-16 54.4 In-house 2-64 (69) alignment
Range on Protein: 1878-1940
Range on HMM: 2-64/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  |.|| | ..|  | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1742-1928 1.7e-16 54.5 In-house 84-276 (302) alignment
Range on Protein: 1742-1928
Range on HMM: 84-276/302.0
DGYRQQKAYI-ATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  .|.| .| .. . | .||| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIgqvhKTKEQFGQDgpISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDE
. . .||  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|. 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

subfamily_hpo-7_pd Subfamily hpo-7 1470-1649 2.4e-16 54.4 In-house 45-227 (263) alignment
Range on Protein: 1470-1649
Range on HMM: 45-227/263.0
ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQFTAWPDHGVPEYPTPF
.|   |....  ... ..||..  .|... ||..|.|    |   . .|..  |       ..|  | .. .   . ..|...... |...  || .   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LAFLRRVKtcnppDAGPIVVHCSAGVGRTGCFIVIDA----MLERIKPEKTVDV--YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|  |. ..     .  ..|||||.|.||.  | |..     |.  ..  .||..     .. .||.|.  ..|  | .|    .|. |
lnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_CG42327_pd Subfamily CG42327 1872-1939 1.2e-15 52.0 In-house 246-314 (319) alignment
Range on Protein: 1872-1939
Range on HMM: 246-314/319.0
QDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
. ||. |||| ||||||. |.  | ....      ||| |.|  .| .|   |.| . |.| |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1416-1560 1.5e-15 51.5 In-house 96-235 (244) alignment
Range on Protein: 1416-1560
Range on HMM: 96-235/244.0
NKPKNRYANVIAYDHSRVILQpiEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRG-TETYG
|  ||| .  . .| .|| |   .| ||  |||| .|        || || || .|  |||.|. |.    .|..  .||.     |.|||.    | | 
nswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewye

-FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
  | ||| |  |.       . .  .    .. .  || . ||  | 
editvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1418-1523 1.5e-15 51.4 In-house 50-168 (349) alignment
Range on Protein: 1418-1523
Range on HMM: 50-168/349.0
PKNRYANVIAYDHSRVIL----QPIEGI----------MGSDYINANYVDGYR--CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC
 |||| ... |.||||.|    .. ..|          .  |||||||.   |   .. ||||| ||| |  ||....  ..   .. ..  .|.|  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPNRgteTYGFIQVTLLDT
|.|| .    .|  |.| | ..
diywqel...sysnitvklqns

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1835-1939 1.9e-15 51.4 In-house 216-343 (350) alignment
Range on Protein: 1835-1939
Range on HMM: 216-343/350.0
TVRQFQFTDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE-------------RMRY-EGVVD-IFQT
 | |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.             .. .   . | |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKMLRTQRPAMVQTEDEYQFCYQAALEY
|. || ||  |||. | . |.|.|.| |
vnelrkqrismvqnldqfifiYeallfy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1698-1797 2.1e-15 51.0 In-house 89-181 (244) alignment
Range on Protein: 1698-1797
Range on HMM: 89-181/244.0
ISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrekCHQYWPAE
  |  | | .|||    .|..  || |   .|  |  ||||||.    .   || || |||.|. |||.|. |    ..|.|  . |       .|||  
kdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds





subfamily_CG42327_pd Subfamily CG42327 1581-1645 3.6e-15 50.4 In-house 246-311 (319) alignment
Range on Protein: 1581-1645
Range on HMM: 246-311/319.0
DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL
. ||.||||| ||||||  |  |  .....   ..||.   |  .| .|   |.| .|| ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

fn3 Fibronectin type III domain 428-513 4.6e-15 48.7 Pfam-A 1-85 (85) alignment
Range on Protein: 428-513
Range on HMM: 1-85/85.0
SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPvgNWQKHNVDDSL-LTTVGSLLEDETYTVRVLAFTSVGDGPLS
|||.|....  ..|.. ..|..| ...| | ||.| | .. .     |.  .|. .    |.  | .. .|..|| | . .| || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 723-821 5.7e-15 48.4 Pfam-A 2-85 (85) alignment
Range on Protein: 723-821
Range on HMM: 2-85/85.0
PPRKVEAEALNATAIRVLWRSPApgRQHGQIRGYQVHYVRMEGAEargpprikdvmlaDAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARS
.|. . ... ..| ... |  |.   ..|.| ||.|.|  ..| |             . .. | .  ......|.|.| | |...|.|.. .| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1372-1466 6.4e-15 49.1 In-house 4-95 (95) alignment
Range on Protein: 1372-1466
Range on HMM: 4-95/95.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPiegIMGSDYINANYVDGYRCQNAYIATQG
|| .. .  |   ...|   .. .|. ||      ..     | | ||||. |.. || .||.|        |||||| .||||  .|.|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_hpo-7_pd Subfamily hpo-7 1752-1926 9.8e-15 49.1 In-house 42-213 (263) alignment
Range on Protein: 1752-1926
Range on HMM: 42-213/263.0
AtqgpLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGV
     | .| . |....  .... ||||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .||...... |.|.  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKSGEGFIDFIGQVHKTKEqfgqdgpISVHCSAGVGRTGVFITLSIVLERMR----Y--EGVVDIFQTVKMLRTQRPAMVQTE
|.  .  .  .  . . |.       . ||||.|.||.  |    .|  .|         . .|  . .. || .|.. ..| 
pelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1543-1646 2.5e-14 47.8 In-house 213-341 (350) alignment
Range on Protein: 1543-1646
Range on HMM: 213-341/350.0
EKREVRQFQFTAWPDHGVPEYPTPFLAFLR----------RVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE-------------RI-KPEKTVDVY
.  .| |.|.  |.| ..   |  .|  |             .  .   . ||.||||||||||| .. .| .|.             .. .. || |. 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

-GHVTLMRSQRNYMVQTEDQYSFIHEALL
   |  .|.||  |||. ||. ||.||||
siivnelrkqrismvqnldqfifiYeall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1579-1648 2.5e-14 47.8 In-house 225-294 (297) alignment
Range on Protein: 1579-1648
Range on HMM: 225-294/297.0
PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 |   ...|||||||||.|  .  |..|.... ..  ||   .. .|.||  .||| .|. ....| |. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1416-1537 3e-14 47.2 In-house 34-156 (332) alignment
Range on Protein: 1416-1537
Range on HMM: 34-156/332.0
NKPKNRYANVIAYDHSRVILQPIEGImgSDYINANYVDGYRCQNAYIATQGPLPE-TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG
|   ||   . ..||||| | | .|    |. ||..||||  ..||| .| |. . |   ||||| |.. . |...  ..|| . |.     .|| |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

FI--QVTLLDTIELATFCVRTFSLH
.       |.  || .  .| |   
lhefgaksleecelkakicrkfwpe

I-set Immunoglobulin I-set domain 136-225 1e-13 42.8 Pfam-A 2-82 (90) alignment
Range on Protein: 136-225
Range on HMM: 2-82/90.0
NIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPsasNGRIKQLRSEtfestpIRGALQIESSEETDQGKYECVATNSAGVR
...  ..  .|.   .... | ..|.|.|...|.||  .. .   . |.|   .|       .  | |.. |. |.|||.|.|||||| .
kftqklkdvevseGesvelectveGepepsvsWakdgselks...sqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagka

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1453-1550 1.2e-13 45.2 In-house 230-323 (440) alignment
Range on Protein: 1453-1550
Range on HMM: 230-323/440.0
DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSrikCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNgsSEKREVRQF
.||  .||.|||| ||  |  ||||.| . | .||.|. .|..|.   |  ||| |  . |.| . |    . ..    |||. |. .   |  |.|||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk..eevheirqf

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1697-1755 2.5e-13 44.0 In-house 40-95 (95) alignment
Range on Protein: 1697-1755
Range on HMM: 40-95/95.0
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGYRQQKAYIATQG
.      .|  |||..||.||..|||.|   |    |||||| |.||| ....|||.||
ytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1705-1936 3.2e-13 44.0 In-house 47-275 (303) alignment
Range on Protein: 1705-1936
Range on HMM: 47-275/303.0
NKFKNRLVNIMPYESTRVCLQpirgveGSDYINASFIDGYRQQKAyIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQ
|  |||.|...  . ..| |        | || ||...   ..|| | || ||. |. |||.|. |..   |..|    |. .   .  .| ..   ...
nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRTV-RQFQFTDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
  .  |  . . .. .     .||    .|. ..     .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .      
ersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

MR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA
.   .  .|. . ....|  |   ||   .. . |   
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll

fn3 Fibronectin type III domain 932-1022 6.1e-13 41.9 Pfam-A 3-85 (85) alignment
Range on Protein: 932-1022
Range on HMM: 3-85/85.0
PQILEAAGNaSAGTVLLRWLPPVpaERNGAIVKYTVAVREAGALGPARETElpaaaEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS
|. | . .. .. .. |.| ||   ...| |..|.| .||.|  .. .|        |. .. .||.||||.| | ..|.|... | ||.|
Penlsvsev.tstsltlsWsppk..dgggpitgYeveyrekgggeewkeft.....vprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_eak_pd Subfamily eak 1708-1859 7.3e-13 42.6 In-house 55-203 (332) alignment
Range on Protein: 1708-1859
Range on HMM: 55-203/332.0
KNrLVNIMPYESTRVCLQPIRgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. |..|  .|.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSgEGFIDF
|    |. . . ||.  ..   .  ..  |  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1708-1795 2.2e-12 41.0 In-house 51-154 (349) alignment
Range on Protein: 1708-1795
Range on HMM: 51-154/349.0
KNRLVNIMPYESTRVCL----QPIRGVEGS----------DYINASFIDG--YRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| ..    .  .| ||||| ||  | .||....  |.  .|. |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1371-1454 5.3e-12 39.8 In-house 4-85 (440) alignment
Range on Protein: 1371-1454
Range on HMM: 4-85/440.0
PPIPIADMAEHTERlkANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG
 || .||.|.. .      |    .|.  .  | .   . ..|  || |||| |..|||||||.|. ..|.  |||||| |..|
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1411-1490 6.3e-11 36.4 In-house 32-116 (347) alignment
Range on Protein: 1411-1490
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGS-----DYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM
.. | .  |||  .|   | .||.| | .  ..       |||| ..    ... || || |||.|  |||.||   . . .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1723-1848 8.4e-11 36.3 In-house 11-125 (130) alignment
Range on Protein: 1723-1848
Range on HMM: 11-125/130.0
ClqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILR
         | .||||||.    . . |. || |||.|. |||.|. |    ..|.|  . |       .|||       |.  ..  ... .  ..|  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdefknika

EF-KVTDARDGQSRTVRQFQFTDWPEQG
.. .. .      ...  || ..|| .|
snleiesdlneshqaltmfqisnwpsdg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1868-1940 8.4e-11 35.8 In-house 260-344 (349) alignment
Range on Protein: 1868-1940
Range on HMM: 260-344/349.0
EQFGQDGPISVHCSAGVGRTGVFITLSIVLE----------RMRYEGVV--DIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .  |  .. |||||| |||||..|| ..|.          .. .. .    |. .|  || || .|||   .. ..|.| |.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

fn3 Fibronectin type III domain 838-916 9.2e-11 34.9 Pfam-A 6-84 (85) alignment
Range on Protein: 838-916
Range on HMM: 6-84/85.0
LSVQQTPEGSLLARWEPPAgTAEDQVLGYRLQFGREDSTP-LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE
||| .. . ||  .|.||. . .... ||....  ....    .   |......| .|   |..|.||..|....| |.|
lsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1705-1789 1e-10 35.6 In-house 34-117 (332) alignment
Range on Protein: 1705-1789
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYESTRVCLQPIRGVEgsDYINASFIDGYRQQKAYIATQGPLAETTED-FWRMLWENNSTIVVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. | . ......  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

Ig_2 Immunoglobulin domain 142-232 3.6e-10 31.7 Pfam-A 8-78 (80) alignment
Range on Protein: 142-232
Range on HMM: 8-78/80.0
QlKVVERTRTATMLCAASGNPDPEITWFKDflpvdpsasngrikqlrS--------EtfestpirgaLQIESSEETDQGKYECVATNSAGVRYSSPANL
.  ||.   . |. |.|.|||.|...| ||                 .        .          | | . ...|.|.|.|.|.|| |   |.. ..
p.tvvtegenvtLtCqapgnptpkvqwykd.................geelsqsqna..........lfipnvsaedsGtYtCrasnsegskqsnsvev

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1411-1542 4.1e-10 32.8 In-house 22-119 (169) alignment
Range on Protein: 1411-1542
Range on HMM: 22-119/169.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAnyvdgyrcqnayiatqgplpetfgdfwRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRgt
..| .|. ||| |  .|  | || || .   .|||||||                           ||.||  .. ||..   ..|     ...||..  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek..

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSS
| | .    .|      .. |||  .|.| | 
edyqlhpavilgewytdslyvrtdkvhantsg

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1411-1542 5e-10 32.5 In-house 21-118 (169) alignment
Range on Protein: 1411-1542
Range on HMM: 21-118/169.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAnyvdgyrcqnayiatqgplpetfgdfwRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRgt
..| .|. ||| |  .|  | || || .   .|||||||                           ||.||  .. ||..   ..|     ...||..  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek..

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSS
| | .    .|      .. |||  .| | |.
edyqlhpavilGewytdslyvrtdkvhpntsg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1742-1821 5.8e-10 33.1 In-house 230-307 (440) alignment
Range on Protein: 1742-1821
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  |  ||||.. . . . ..|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr

I-set Immunoglobulin I-set domain 245-328 8.2e-10 30.4 Pfam-A 1-90 (90) alignment
Range on Protein: 245-328
Range on HMM: 1-90/90.0
PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNV----LELTDV--KDSANYTCVAMSSLGVIEAVAQITV
|.|.. . . |.. | .|...| . |.| | |.|... ..|...... |  .     |....|  .|. .|||.|  |.|  || |...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_eak_pd Subfamily eak 1570-1649 1.9e-09 31.3 In-house 226-305 (332) alignment
Range on Protein: 1570-1649
Range on HMM: 226-305/332.0
FLRRVKtCNPPDAGPIVvHCSAGVGRTGCFIVIDAMLERIKPEKTvDVY---GHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.|.. .   ||   ||.  .. |  |.| |.||| ... |   |. ..|     .  ..|.|.. | .. |.|||.|..|. .
tlkkyi.htppsfapii.qsarGsaraGvfvvidllirlidnkkk.nlysvedlilkvkskrihsvlvalqhsfiyeivldyl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1699-1744 1.9e-09 31.4 In-house 41-86 (440) alignment
Range on Protein: 1699-1744
Range on HMM: 41-86/440.0
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGY
 |.|| || |||  ||. |. .|| |. ..||  |||||||.|.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

Ig_2 Immunoglobulin domain 47-115 2e-09 29.4 Pfam-A 14-70 (80) alignment
Range on Protein: 47-115
Range on HMM: 14-70/80.0
GGVASFVCQATGDPKPRVTWNKKGKKVNSQRFEtiefdesagavlRIQPLRTPRDENVYECVAQNSVGE
|    . |||.|.|.|.|.| |.|....... .             ..|. .. |  .|.|.|.|| | 
genvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegs

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1695-1779 4.1e-09 30.4 In-house 27-116 (347) alignment
Range on Protein: 1695-1779
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-----SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|.| |..   .  |||  .    ..||| | | .   .       ||||| |     .| || || || .|  |||.|.   . | || .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1428-1560 4.8e-09 30.6 In-house 5-126 (130) alignment
Range on Protein: 1428-1560
Range on HMM: 5-126/130.0
YDHSRVIlqpiegimGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRGT-ETY-GFIQVTLLDTIE
.. ||.         | .||||..|      . |. || || .|  |||.|. |.    .|..  .||.     |.|||.    | |   | ||| |  |
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrde

LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
        .  ...    .. .  || . ||  | 
fknikasnleiesdlneshqaltmfqisnwpsdgt

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1698-1798 5.5e-09 29.2 In-house 20-88 (169) alignment
Range on Protein: 1698-1798
Range on HMM: 20-88/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWENNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpek

R
 
e

subfamily_PTPDC1_pd Subfamily PTPDC1 1864-1934 6.2e-09 30.5 In-house 105-170 (182) alignment
Range on Protein: 1864-1934
Range on HMM: 105-170/182.0
HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVlermrYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .  ... .
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1698-1797 7.2e-09 28.7 In-house 19-86 (169) alignment
Range on Protein: 1698-1797
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWENNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek





subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1545-1647 8.5e-09 29.2 In-house 218-342 (349) alignment
Range on Protein: 1545-1647
Range on HMM: 218-342/349.0
REVRQFQFTAWPDHGVPEYPTPFLAFLRrVKT-----------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE----------RIK-PEKTVD-VYGHV
 |. |.|.  |.| ..   |  .|  |  ||             .  .  ...|||||| |||| .. .| .|.          .|| . .. | ..  |
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

TLMRSQRNYMVQTEDQYSFIHEALLE
  .| ||  |||   |. .|.||||.
nelrkqrismvqnlaqfiaiyealLk

0038934 (Phosphotyrosine protein) phosphatases II 1553-1641 2e-08 29.6 In-house 85-169 (194) alignment
Range on Protein: 1553-1641
Range on HMM: 85-169/194.0
TAWPDHGVPEYPTPFLAFLRRVKTCNPPD-AGPIVVHCSAGVGRTGCFIVIDAML-ERIkpeKTVDVYGHvtlMRSQRNYMVQTEDQYSFI
  .||.|..      | ||. |.. .  |  | ..||| ||.||||....   .   ..   .  . ...   .|. |. .... |... .
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm...saeeAial...frekRpgaipnqdyleal

subfamily_PTPDC1_pd Subfamily PTPDC1 1544-1643 7.5e-08 27.0 In-house 80-170 (182) alignment
Range on Protein: 1544-1643
Range on HMM: 80-170/182.0
KREVRQFQFtAWPDHGVPEYpTPFLAFLRRVKTCnpPDAGPIVVHCSAGVGRTGCFIVIDAML-ERIKPEKTvdvyghVTLMRSQRNYMVQTEDQYSFIH
....  ..| .|.|.||.   .  |   . |. .   . | . ||| || ||||  |    .  .|...||.      ..|.||.|   .|| .|  ...
eqgiyvynf.gwkDygvasl.eriLdivkvvafa..lqegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvk

E
|
e

Ig_2 Immunoglobulin domain 255-318 9.4e-08 24.0 Pfam-A 10-70 (80) alignment
Range on Protein: 255-318
Range on HMM: 10-70/80.0
EIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTpeddmpVGRN--VLELTDVKDSANYTCVAMS-SLG
..  | ||..|| | | | | |.| .. | |.       ..|   . .. ..|| .|||.|   ...
vvtegenvtLtCqapgnptpkvqwykdgeels......qsqnalfipnvsaedsGtYtCrasnsegs

0038934 (Phosphotyrosine protein) phosphatases II 1844-1931 1.1e-07 27.2 In-house 85-168 (194) alignment
Range on Protein: 1844-1931
Range on HMM: 85-168/194.0
W--PEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVL-ERMryegvvDIFQTVKMLRTQRPAMVQTEDEYQF
.  |..|.. | |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .  . ....|  || .... | .. 
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdylea

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1401-1455 1.2e-07 25.6 In-house 24-77 (244) alignment
Range on Protein: 1401-1455
Range on HMM: 24-77/244.0
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgIMGSDYINANYVDGY
|  ..|    . | .|  |||| |.. .|..||||   .   |||||||||..| 
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs

Ig_3 Immunoglobulin domain 42-111 1.7e-07 23.4 Pfam-A 11-75 (75) alignment
Range on Protein: 42-111
Range on HMM: 11-75/75.0
QIGVSGGvASFVCQATGDP-KPRVTWNkkgkKVNSQRFETIEFDESAGAVLRIQPLRtPRDENVYECVAQN
 . ..|.  .. |.|.| | .|...|     . ... ... |   | ...| | .   . |  .|.|||.|
tvtsggn.vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvt.sedsGtYtCvasN

Ig_3 Immunoglobulin domain 148-220 4.2e-07 22.1 Pfam-A 9-75 (75) alignment
Range on Protein: 148-220
Range on HMM: 9-75/75.0
RTRT-----ATMLCAASGNP-DPEITWFkdflpvdpsasnGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATN
.. .      |  | | |.|  | |.|                 . .. .  | .. . | |.|  . | | |.|||.|
sptvtsggnvtLtCsaeggpppptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvasN

ig Immunoglobulin domain 259-313 8.4e-07 20.2 Pfam-A 1-64 (64) alignment
Range on Protein: 259-313
Range on HMM: 1-64/64.0
GGNVNITCVA-VGSPMPYVKWMQGAEDLTPEDDMPVGRNV------LELTDVK--DSANYTCVA
|..|..|| .  |.|.. | | ..   |....   | .|       |....|.  || .||||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv

Ig_3 Immunoglobulin domain 254-314 8.8e-07 21.1 Pfam-A 10-74 (75) alignment
Range on Protein: 254-314
Range on HMM: 10-74/75.0
HEIMPGGNVNITCVAVGSP-MPYVKWM-QGAEDLTPEDDMPVGRNVLELT--DVKDSANYTCVAM
  .  ||||..|| |.|.|  | . |. ..   | . ..   . ..| ..  . .|| .||||| 
ptvtsggnvtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas

fn3 Fibronectin type III domain 1036-1099 2e-06 21.1 Pfam-A 2-73 (85) alignment
Range on Protein: 1036-1099
Range on HMM: 2-73/85.0
SPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQYN-------GLTLDVDGRTTKKLITHLKPHTFYNFVL
.|.|..|. .  ||. |||. | |.    | |...|          . .|.. ||   .|.|||.| |.| .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV

subfamily_PRL_pd Subfamily PRL 1863-1910 3.1e-06 21.3 In-house 80-127 (151) alignment
Range on Protein: 1863-1910
Range on HMM: 80-127/151.0
VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQ
. |.| .   .  ..||| ||.||. |...|... . |.||  |.. .
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefir

ig Immunoglobulin domain 47-109 6.1e-06 17.5 Pfam-A 1-64 (64) alignment
Range on Protein: 47-109
Range on HMM: 1-64/64.0
GGVASFVCQA-TGDPKPRVTWNKKGKKVNSqrFETIEFDESAGA---VLRIQPLRTPrDENVYECVA
|. . ..| . .|.| . |.| |.||  ..  .... ..|  .    || |...    |. .|.||.
GssvtLtCsvssgppstdvsWykegkglee..sqktgvvenrvsaqevLtinnvtke.dsGtYtCvv

subfamily_CDC14_pd Subfamily CDC14 1873-1928 7.2e-06 20.1 In-house 263-313 (328) alignment
Range on Protein: 1873-1928
Range on HMM: 263-313/328.0
DGPISVHCSAGVGRTGVFITLSIVlERMRyegvVDIFQTVKMLRTQRPAMVQTEDE
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  .
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqq

PTPc_motif_SM00404 1831-1924 7.9e-06 20.8 In-house 44-126 (140) alignment
Range on Protein: 1831-1924
Range on HMM: 44-126/140.0
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQ
 ..... | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||.. ... . ..... .||.. .
nsgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrq.lslaeayefvkerRpiisp