Gene PTPRS in Homo sapiens

Synonym: PTPSIGMA, PTPRS

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP098_AA protein Get Run
HsapP098_AA_1375-1650 phosphatase_domain Get Run
HsapP098_AA_1662-1941 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1370-1696 3.3e-172 569.0 In-house 2-329 (564) alignment 
Range on Protein: 1370-1696
Range on HMM: 2-329/564.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
..|||.|...||...||||..||...||..|..|||||||..| ..||.||||||..|||||||.|...||  |||||||...|||| ..|||||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLA
||. |||||||||.|.||||.|.||||.. ||..|||..|||||| ..||| .. |||....|||.|.|. |||.||||||.||.||||||||..|..|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
..|.|...|.||||||||||||||||||.|||||||||||| |||||.|..|...|.|||.|||||.||.|||||.|||. ||||||....|.. .||||
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QVEPGEHVTGMELEFKRLANSK-AHTSR
.||.....||.||||.|||..|  ....
eveedtemtgleleFqrLatakeielee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1373-1687 9.5e-135 443.7 In-house 2-318 (318) alignment 
Range on Protein: 1373-1687
Range on HMM: 2-318/318.0
IPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|.. |...| .||... .|.||.||| ...  ...|. .|. .||| ||||||..||||.|| ||..|| .|||||||||.|||| ..||||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
. ||||||||| ||.|||.|..||....|...|||..|...|| ..|.| ...||... .|.|........|.|.|||...|.|||.|||| .. .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQ
|.|.. . ...|||||||||||||||| ||..|..||||| |..|||.. |. .|.||| |||||||| ||...||||. .|.||| |. | . |..| .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

VEPGEHVTGMELEFKRL
..|    | |..||.||
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1693-1945 1.6e-128 424.8 In-house 36-286 (564) alignment 
Range on Protein: 1693-1945
Range on HMM: 36-286/564.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
..... .|| |.|| |||. ||..|...||.|....|.|||||||||||||||..|||||||||||||.||||||.||.||...||||||.|.|..|||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
|||......|....|....|... .|..|.||...... .||.||||.||.||..|||.|.....|.| .|....|   . ||| |||||||||||.||.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfiv

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH
....|||...|..|||.|.||.||.||.||||||. |.|...| ||.| ... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1372-1685 1.5e-118 390.5 In-house 4-319 (319) alignment 
Range on Protein: 1372-1685
Range on HMM: 4-319/319.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
.|......|....|... . .| .|.. .. ....|..... | ||.|||| |..|||..||.|....|. |||||||...|||. ....||||.|| .|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAF
. ||||||||..| ..||.|.| || ..|. .|||.   |.|| . |||..  ||. . .| ..|.|.    | ||| .||.|.||||.|||. |  |..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
|.|..     ...||||||||||||||| |||.||||||.| | ..||.  |  .| ||| |||...||.||.||||||| .|.||.  . |   ...||
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

QVEPGEHVTGMELEFK
. ...   ||.| ||.
ekvadtgetglerefq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1678-1947 1.3e-116 384.1 In-house 20-287 (318) alignment 
Range on Protein: 1678-1947
Range on HMM: 20-287/318.0
TGMELEFKRLANSKAHTSRFISaNLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
. .. |..||. |....... | . |.||.||| .||..|..||| ||.. |.||||||||..|||||..|||||.|.||.|| ||||||.|| ||...|
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdGPIS
|||...| |..|.|.||| . |  |.  ||. . | .. .|.|||||||     .||.|||...|.||..|||.|| ...|...||.|.... |. ||| 
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
||||||||||||||...|.|||.. |..||.|||||.||.||..|||||| |.|.|.. ||.| |.| ..
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
0040438 (Phosphotyrosine protein) phosphatases II 1376-1688 1.8e-113 374.2 In-house 3-315 (317) alignment 
Range on Protein: 1376-1688
Range on HMM: 3-315/317.0
ADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF
 |. .. ..|...|  .|..|.| ..  .  |.....|..||.|||| ... ||||||.|.|..|...||||||.||||.......||||||||.|..||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVK
|||||||.. .|||.|.|||..|.||.||||...| ||| ..||||...||| ...||. . ..|.||.|.|..|..|.|||||||..|...|.||..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

TCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGE
...... ||..|||||||||||.||... |||... |..|||.  |  .|.||...|||..|| |...|||| . ...| .|| .|. ...|| .. ...
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

HVTGMELEFKRLA
 |...| |.|.| 
dvklkekelklll
subfamily_PTPRG_pd Subfamily PTPRG 1373-1662 2.2e-112 371.1 In-house 1-300 (563) alignment 
Range on Protein: 1373-1662
Range on HMM: 1-300/563.0
IPIADMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGS-DYINANYVDGYRCQNAYIATQGPL
.|. ..|.|   |.|..  ..|.|.|..      .... |||. . || |||| |..|||.||| |.|. |. .. |||||||.|||. ..|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK----NGSS--EKREVRQFQFTAWPDHGVPE
..|| |||||.|||..|.|||.| |.|. | |||.|||. ..|||| .|||| ..  ||.  |||.....    ....  ....|||...| ||||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY
...| | | .. .. |. .|||||||||||||||| .||.|..|..|. |..|.|.| .  .|.|||..||||.|| |.|.|||||.  ..||. |  . 
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
0051299 (Phosphotyrosine protein) phosphatases II 1370-1648 3.4e-110 363.2 In-house 2-285 (288) alignment 
Range on Protein: 1370-1648
Range on HMM: 2-285/288.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
. .|.. ..... ..|.||.  .| .|.| . . . ..|. ...|. |..|||| ....||||||.|....|. |||||||.|.|||......|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN----GSSEKREVRQFQFTAWPDHGVPEYP
|.|..|||||||||.. .|||.|.|.|..|.||.||||..|..||| |.||||.. .|....|||. . ..    |..|.|.|..|..|.|||||||..|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
...|.|||.|....... ||.||||||||||||.||..| .||... |..|||.. |  .|.||..||||..|| |..|||||.
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRK_pd Subfamily PTPRK 1370-1683 2.4e-109 360.0 In-house 1-311 (314) alignment 
Range on Protein: 1370-1683
Range on HMM: 1-311/314.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGqqftWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
|| | .||. ..   ||....  . .||||.  |    |. .. . |. |||. ...|||.|||.|..|.|   ||||||...|.|.  .|.|.|||||.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTEtYGFIQVTLLDTIELATFCVRTFSLHK--NGSSEKREVRQFQFTAWPDHGVPEYPTPF
||  ||||.|.....|.|||.| | |..|.|| .|||. ..  || |.|.|..|  || . ||.|...|   | .|.||||||||..||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK
|...||||. ....||.|||||||| ||||.||.|| .|. |. |..|||.  |  .||..  ||.||.|| ||....|||. ||.| .|.  . |   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LAQVEPGEHVTGMELE
  ...|    . .. |
sirldpqtnssqlkee
subfamily_PTPRA_pd Subfamily PTPRA 1370-1684 2.9e-109 359.9 In-house 11-330 (330) alignment 
Range on Protein: 1370-1684
Range on HMM: 11-330/330.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
..|.|. .. |  .. .|.|. .. .|....     | | | .. | || |||. |.. ||.|||||...||.  |||||| ..|||. .. .||.|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS----SEKREVRQFQFTAWPDHGVPEYP
 ||  |||||.|||.||||||.| |.|. . || ||||. |. ||| |.|.. |. .|  . || | ... .      ..| |||| ||.||| |||  |
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
   | .|..||..|.  |||||||||||||||| |||.||.|||.| |. |||.. |  .| ||  ||||. || ||...|||    |.||. . ||  .
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

IQKLAQVEPGEHVTGMELEF
.||| .  .| . .|.| ||
lqklynkitgtdkigleeef
0050432 (Phosphotyrosine protein) phosphatases II 1367-1651 2.3e-107 354.2 In-house 20-301 (308) alignment 
Range on Protein: 1367-1651
Range on HMM: 20-301/308.0
MLSHPPIPIADMAEHTERlkANDSLKLSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVILqpieGiMGSDYINANYVDGY--RCQNAYIA
. |. .... |.... |.  |.|. .|..|.| .   .  .......|. ||.|||| ....||||||.|    .  |||||||.|||||  ......||
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIa

TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR---GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
||||||.|..|||||||||.. .|||.|.|.|..|.||.||||.    |...|| ..||||.. .|....|||. | ..|..| |.|..|..|.||||||
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

PEYPTPFLAFLRRVKTCNPPdaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
|..|...|.||..|....|.  |||||||||||||||.||..| .||... |..|||.. |  .|.||..||||..|| |...|||| . .
Ppspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_PTPRB_pd Subfamily PTPRB 1371-1649 4.7e-107 352.4 In-house 5-285 (293) alignment 
Range on Protein: 1371-1649
Range on HMM: 5-285/293.0
PPIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
 || . ...|| ...||.. |..|.|||..   |.. . . ..|.||. |||| |...|||||| |.....  |||||||||..||.... .||||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHGVPEYPTPFL
||. ||||||||..| .|||.|.| || ..||..|||.   . .|| |.|||. . ||  . .|.....|  ..|.|.|||..||.|||||||| ....|
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

AFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.|.|.|..      ...|||||||||||||| || .| .|..|. | .||..| |. .|..||..||||.|| |||...|. .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1377-1656 4.4e-105 346.2 In-house 13-297 (298) alignment 
Range on Protein: 1377-1656
Range on HMM: 13-297/298.0
DMAEHTERLKANDSLKLSQEYESIDPGQQ----FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETF
 . . ..  |...  ....|.. .. ...    ...| .. . || |||||..||.|.|||.|. ...   |||||| ....|. .||.||||.||.||.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

GDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLR
 ||||||.|. ..||||.| |||. ..|. .|||..|.|||| |.|.|| . | | . ||.. ..|. ....|||||..|| |||.||||. |  |..||
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

RVKTcNPPDAG--PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
.|.. .. .||  |..|.|||||||.| ||.||..|||.| |..|||.  |  .| .|  .||||.||.||.|| |||. ..|.|.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0050432 (Phosphotyrosine protein) phosphatases II 1647-1945 1e-103 342.1 In-house 10-304 (308) alignment 
Range on Protein: 1647-1945
Range on HMM: 10-304/308.0
EAVGCGNTEVPARSLYAYIQKLAQ-VEPGEHVTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGvEGSDYINASFIDGY-
|.. ...|.... ||. ....|.. .|.    ...| ||..| . |     . .|.||.|| ||| ..|.||...||.|    . |||||||||..||| 
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgys

-RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE---RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
 ......||||||| .|.||||||.||.|....|||||| |.|||||.|||| |    | .| .|.|  . |.... |..|....|. .||.||||..|.
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.|.||..||| | | ..||. .|.|.     ..||| |||||||||||.||.| ..||....|| ||.|..||.||.||| ||||.. |.|.|.|.||||
ytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

GSFDH
 .. .
klklt
0051299 (Phosphotyrosine protein) phosphatases II 1652-1940 2e-103 341.1 In-house 1-286 (288) alignment 
Range on Protein: 1652-1940
Range on HMM: 1-286/288.0
GNTEVPARSLYAYIQKLAqvepGEHVTGMELEFKRLANSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI
|.||.....|. ...||       ..||.. ||..| . ...   . .|.||.|. ||| ..|.||...||.|... |||||||||||.||||......|
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQ
|||||| .|.||||||.||.|....|||||| |.|||||.|||| . |  |  ..|  . |. .. |..|...||.      ||.||||..|..|.||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||| | | ..||. .|.|  .   ..||. |||||||||||.||.| ..||....||.||....||.||.||| ||||.. |.|.|.|.||||
gvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1372-1647 9.3e-103 338.7 In-house 1-275 (278) alignment 
Range on Protein: 1372-1647
Range on HMM: 1-275/278.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
||.. |.... ..|..|.  .|..|.|...  . .|.....|. ||.|||| ....||||||.|....| ..||||||.|||||......||||||||||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPnRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
..||||||||... ||||.|.|.|..|.||.|||| .|..||| ..||||....|....|||. ....|..|.|.|.......|||||||| ....| ||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
..|....... ||..|||||||||||.||... .||... |..||..  |  .|.||  .|||..|| |..|||||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 1362-1654 1.4e-101 335.1 In-house 3-294 (297) alignment 
Range on Protein: 1362-1654
Range on HMM: 3-294/297.0
FHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQfTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGI-MGSDYINANYVDGYRC-QN
. ....|...|||.  .. .  ..|||.. .| .|.|..   .   .....|..||.|||| ....||||||.|.|..|  ..||||||.|||||.. ..
plrdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTeTYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHG
..||||||||||..|||||||||.. .|||.|.|.|..| ||.||||..|. ||| ..||||....|. ..|||... .  ..| |.|..||.| |||||
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhg

VPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
||.... .| ||. |....   |. ||..|||||||||||.||... |||... |..|||.  |  .|.||...|||..|| |...|||| . ...|
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1652-1947 2e-101 334.2 In-house 1-297 (298) alignment 
Range on Protein: 1652-1947
Range on HMM: 1-297/298.0
GNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKA--HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA
||||. |..| | .||||.|.. ...||..|||.|| . .   ..     |. | || |||  .|....|.|| |. . . | ||||||||...|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
.||||.|| ||.||||||..|.... .||||.|.|... |.|.||| |....|  . |. ...... ..| |..||....  ..|.|||..|| ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
|.  .  .|.. .|.....| | . |. |.|||||||.| || .. ||||.. | |||.||.||.||..||..||||..| |.|.| ||.| ||. ..
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1678-1944 3.8e-101 333.3 In-house 23-287 (319) alignment 
Range on Protein: 1678-1944
Range on HMM: 23-287/319.0
TGMELEFKRLANSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
|..| ||| | ....    | ||. . || |||  ||..|. ||| |... ||||||||||||||||......||||.||..|.||||||.||..| |||
tllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ-SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPI
||||| | .. |...||| |   .|  ..|..  | .. .|| |..|.  . .   .|.| .||.|.||...||... . .|......|..|.  |.|||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPi

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
 ||||||||||| ||.|...|||.. |||.|.|.||..|||||. |||... |.|.|.| ||.. ..|
vvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0036941 (Phosphotyrosine protein) phosphatases II 1385-1663 4e-101 333.5 In-house 7-291 (297) alignment 
Range on Protein: 1385-1663
Range on HMM: 7-291/297.0
LKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILqpiEGiMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR
 |.... .|..|.|...| . ........|. |..|||| ....|||.||.|   ..  |||||||.|||||......||||||||.|..|||||||||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SATIVMMTRLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIE--LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP
. .|||.|.|.|. |.||.||||.   .. ||| ..||||.. .  |.....||. . ..|..|.|.|..|..| ||||||||.|...|.|...|.....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

P--DAGPIVVHCSAGVGRTGCFIVIDAMLERIK---PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYA
   . ||..|||||||||.|.||..| ||....    |..||..  |  .|.||. .|||..|| |..||||| . ...| .|...|. 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0046845 (Phosphotyrosine protein) phosphatases II 1393-1654 4e-101 333.4 In-house 2-279 (284) alignment 
Range on Protein: 1393-1654
Range on HMM: 2-279/284.0
LSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG-IMGSDYINANYVDGY-----RCQNAYIATQGPLPETFGDFWRMVWEQR
| .|.| .   . .   ......|. |. |||| ....||||||.|....| . .||||||.|||||     ......||||||||.|..|||||||||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SATIVMMTRLEEKSRIKCDQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--
. .|||.|.|.|..|.||.||||. | . ||| ..||||.. .  ...|||..| ..| ..| |.|..|..|.|||||||..|...|.||| |.....  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK---TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
|. |||||||||||||||.||..| .||... |.   .|||.. |  .|.||..||||..|| |..|||||.. ...|
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0047943 (Phosphotyrosine protein) phosphatases II 1386-1648 1.9e-98 324.6 In-house 7-271 (273) alignment 
Range on Protein: 1386-1648
Range on HMM: 7-271/273.0
KANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILqpieGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS
|.... .| .|.| . . . ..|.....|. || |||| ....||||||.|    |  |||||||.|||||......||||||||.|..|||||||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ATIVMMTRLEEKSRIKCDQYWPNRG---TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPP-
 .|||.|.|.|..|.||.||||. |   ..||| ..||||.. . ....|||. | ..|..|.|.|..|..| |||||||......| |.. |....   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 . ||.||||||||||||.||..| .|.... |..|||.  | |.|||| .||||..|| |..||||| 
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0046845 (Phosphotyrosine protein) phosphatases II 1679-1943 2.3e-98 324.3 In-house 1-277 (284) alignment 
Range on Protein: 1679-1943
Range on HMM: 1-277/284.0
GMELEFKRLANSKAHTS-RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGY-----RQQKAYIATQGPLAETTEDFWRMLWEN
|.| ||..| . . . .  .  |.||.|. ||| ..|.||...||.|... |  |.|||||||..|||     ...|..||||||| .|.||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
|....||||.| |.|||||.|||| |  . .|  | |  . |.... |..|....|.   .|.||||..|..|.||..||| | | ...|. .|..  |.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG---VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
....||| |||||||||||.||.| ..||....||   .||....||.||.||| ||||.. |.|.|.|.|||| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0045450 (Phosphotyrosine protein) phosphatases II 1370-1648 8e-98 323.2 In-house 6-303 (307) alignment 
Range on Protein: 1370-1648
Range on HMM: 6-303/307.0
HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQF---TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGI-MGSDYINANYV--------DGYRC
...|.. ..  .  .|....  .| .|.|.. . . |   ......|..||.|||| ....|||.||.|....|   .||||||.||        |||..
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE-TYGFIQVTLLDTIELATFCVRTFSLHKN-GSSEKREVRQFQFTAW
....||||||||||. |||||.|||.. .|||.|.|.|. |.||.||||. |.| ||| ..||||.. .|. ..|||. .. . |..| |.|..|..|.|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

PDHGVPEYPTPFLAFLRRVKTCNPP--DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
||||||... ..|.|...|....    . ||..|||||||||||.||... ||.... |.|   ||..  | |.|.||  .||...|| |..||||| 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 1678-1940 1.8e-97 321.7 In-house 18-276 (317) alignment 
Range on Protein: 1678-1940
Range on HMM: 18-276/317.0
TGMELEFKRLANSKAHtsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
|... ||..| . | .   .  |.||.|| ||| ..|.||...||.|.|. |...|||||||..||.......||||||| .|.||||||.||...|..|
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
|||.| |.|||||.|||| . .  |  |.|  . |. .. ..||...|.| .|..||||..|..|.||..|||.| . ..||. .|..  |  ...||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||||||||||.||.. ..||....|| ||....||.|| ||| .|||.. |.|.|.|.||||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 1674-1940 9.2e-97 319.0 In-house 8-272 (273) alignment 
Range on Protein: 1674-1940
Range on HMM: 8-272/273.0
GEHVTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS
  ..|....||..| . |     .  |.||.|| |||  .|.||...||.|    | .||||||||..|||......||||||| .|.||||||.||.|.
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TIVVMLTKLREMGREKCHQYWPAER---SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF
...||||.| |.|||||.|||| |    | .|  | |  . |.. . |..|....|.  .|.||||..|..|.||..||| | | ...|| .|.|. |..
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ..||. |||||||||||.||.| ..|.....|| ||....||.||.||| ||||.. |.|.|.|.||||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1379-1648 3.8e-96 316.5 In-house 9-278 (288) alignment 
Range on Protein: 1379-1648
Range on HMM: 9-278/288.0
AEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWR
 ... . .|..   .|.||.|.   ... . . ..| ||..|||| |...||. || |.  |   |.|||||.|.||.. ...||||||||..| .|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-ETYGFIQVTLLDTIELATFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT
.|.|... ||||.| | |. . ||..|||. .. . || ..|||... ||  | .|.. |.|.   ...|. |.|..|||||||||  .|.|..|| ||.
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkv

CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 |. |.|||.||||||||||| ||..||...... |...|| | |. .| ||. .|||. || ||.|.||. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0039614 (Phosphotyrosine protein) phosphatases II 1671-1943 1.5e-95 315.3 In-house 25-292 (297) alignment 
Range on Protein: 1671-1943
Range on HMM: 25-292/297.0
VEPGEHVTGMELEFKRLANSKAHtsrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRML
.|.    |...|||..| . |     .  |.||.|| ||| ..|.||...||.|.|..|| ..|||||||..|||.. ....||||||| ||.||||||.
lekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WENNSTIVVMLTKLREMGReKCHQYWPAERSaRYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE
||...|..|||||| |.|| ||.|||| | . .|  |.|  . ..  . |..|...||.  .|.||||..||.|.||. ||| | | ...|. .|..  .
weqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
. ...||. |||||||||||.||.. ..||....|| ||....||.|| ||| .|||.. |.|.|.|.||.|  .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1664-1940 4.3e-95 314.2 In-house 13-304 (307) alignment 
Range on Protein: 1664-1940
Range on HMM: 13-304/307.0
YIQKLAQVEPGEHVTGMELEFKRLANSKAH-TSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV-EGSDYINASFI--------DGYRQQKAYIAT
.. .| .... ...||.. ||..| . . .    . .|.||.|| ||| ..|.||..|||.|... |  |.|||||||..        |||......|||
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQYFVVDPMAEYNMPQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPK
|||| || |||||||||...|..||||.| |.|||||.|||| |..   |  |.|  . |. .. |..| ..|||   .|.||||..|..|.||..|||.
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|.....||.   ||....||.|| ||| .||... |.|.|.|.||.|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 1677-1943 7.5e-95 312.9 In-house 12-280 (297) alignment 
Range on Protein: 1677-1943
Range on HMM: 12-280/297.0
VTGMELEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLqpirGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 .... ||..| . ..    .  |.||.|. |||  .|.||..|||.|    . |||||||||..|||......||||||| .|.||||||.||.|.|..
lalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTKLREMGREKCHQYWPAE--RSARYQYFVVDPMAEYN--MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
||||.| |.|||||.|||| |   |  |  |.|  . ..    . |.||...||| ..|.||||..|..|.||. ||| | . ..||| .|.|  ... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

DGPISVHCSAGVGRTGVFITLSIVLERMR---YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
.||. |||||||||.|.||.. ..|....   .|| |||...||.||.||| .|||.. |.|.|.| ||.| ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0043336 (Phosphotyrosine protein) phosphatases II 1677-1940 9.5e-95 312.5 In-house 19-277 (278) alignment 
Range on Protein: 1677-1940
Range on HMM: 19-277/278.0
VTGMELEFKRLANSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 |...|||..| . |     .  |.||.|| ||| ..|.||...||.|... |...|||||||..|||......||||||| ||.||||||.||...|..
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLTKLREMGREKCHQYWPaERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPI
||||.| |.||.||.|||| . | .|  |.|  . |. .. |..| ..||. .||.||||.......||..||| | . ..||. .|..  |   ..||.
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpv

SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 |||||||||||.||.| ..||....|| ||....||.||.||| .|||.. |.|.|.|.||||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 1393-1648 1.5e-94 311.5 In-house 2-261 (263) alignment 
Range on Protein: 1393-1648
Range on HMM: 2-261/263.0
LSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|..|.|...  . . . .... . || |||| |.. |||.||.|...|.  |||||||||..|......|||||||||.|. ||||||||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIELA-TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
. ||. ..|||.|||.   |.||.| |.|.| ....    . .||..| |.| .|.|.|.|.|...|||||||. ....|..|| ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|||||||||.|..|| .|.... ||.||.   |. .|.||  ||||..||.||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1393-1648 1.5e-94 311.5 In-house 2-261 (263) alignment 
Range on Protein: 1393-1648
Range on HMM: 2-261/263.0
LSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|..|.|...  . . . .... . || |||| |.. |||.||.|...|.  |||||||||..|......|||||||||.|. ||||||||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIELA-TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
. ||. ..|||.|||.   |.||.| |.|.| ....    . .||..| |.| .|.|.|.|.|...|||||||. ....|..|| ||...    ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|||||||||.|..|| .|.... ||.||.   |. .|.||  ||||..||.||.||.||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRA_pd Subfamily PTPRA 1695-1939 1.6e-94 311.5 In-house 48-294 (330) alignment 
Range on Protein: 1695-1939
Range on HMM: 48-294/330.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW
. .  |.   || |||.|||.||. .|| |....||| ||||||||||||.... .||.|||..|| ||||||.|| .|. .||||.|.|  .|||.|||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdgPISVHCSAGVGRTGVF
| | .  |    |    |  . .| .|.| |..     |. .|| |||| || ||. |||  . | .... .|.|...| ..  || ||||||||||| |
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtf

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
|.|. ||||.. |..||.|..|| ||.||| ||||.  |.|.|.. |||
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1372-1669 2.9e-94 310.6 In-house 3-303 (305) alignment 
Range on Protein: 1372-1669
Range on HMM: 3-303/305.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGqQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
.| ..|.|.. .  ..... .| ..|.|.    . . .  . |.|| |||..... .|..|.||.. |    ||||||.|||||. ...||..||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFSLHK-NGSSEKREVRQFQFTAWPDHGVPEYPTPFL
  ||||...| .  ||||.|.| |  . || ||||.. ||   .| ..|.| .. . . .  | ... . ....|.| | |.|.| |||||||...| .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

AFLRRVKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK
 ...||.     | | |..||||||||||| ||..| .|||.| |..|||.. .  .||.| .|||| ||| |.|.|| | . ||.|..    | | ..|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LA
| 
lk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1369-1662 3.4e-93 307.0 In-house 2-291 (315) alignment 
Range on Protein: 1369-1662
Range on HMM: 2-291/315.0
SHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPL
.| |||. ..  .  . ||.    . |.||||  || .  . ..   || |||| |.||||.||| |  .|   .|||.|||..|||  .. |||.|||.
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

PETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRgTETYGFIQVTLLDTIELATFCVRTFSLHKngSSEKREVRQFQFTAWPDHGVPEYPTPFL
... .||||.|.|.  ..|||.| | |. . |...|||..   .|| | ||. .      ..|||.|      .. ||| |...|.||| |||.| .|..
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplm

AFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVpARSLY
 . |.||  .  ..|.||||||||||||| || .||.|.... |. .|||  .| .|..|  |||. .|| ||..||||.. ||.| . |. ||
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdly
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1415-1651 1.3e-92 304.6 In-house 8-244 (250) alignment 
Range on Protein: 1415-1651
Range on HMM: 8-244/250.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIkCDQYWPNRGTETYG
 || |||||..||.|.|||.|.. .|   |||||| ...||. ..|.|||||||..|. ||||||.|. |.||||.| |.|. .  . ||||  ..|.||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK
 ..|.||.. | | . .|.. | |.  ...| |||..|..||| ||||. |  |..|..|.. ..  ...|..|.|||||||.|.||.|||.|||.| ||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
.|||.  .  .| .|  .|....||.|..|..|.|. .
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1371-1669 4.4e-92 303.8 In-house 14-311 (319) alignment 
Range on Protein: 1371-1669
Range on HMM: 14-311/319.0
PPIPIADmAEHTERLKAND-SLKLSQEYESI--DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGP
|..|.    . . . ...|   ||  |.  .   . .  . ...||. || |||. |..|.|...| |....|. .|||||| .|.||. .. |||.|||
pdfpayy.qqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGP

LPETFGDFWRMVWEQRSATIVMMTrleeksRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTP
|..|  |||||.||....|||..|      . || ||||... ....  .| .    | | . || . | ..|   ..|...|| |  |||.|||.||..
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd

FLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
.. ....|.  .    .  .||||||||||||| .||.|..|.|.| || ||||  |  .| ||| .||   || ||. ||||    |...|    . ||
lmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

IQKLA
...|.
leels
0040439 (Phosphotyrosine protein) phosphatases II 1407-1649 6.7e-92 302.8 In-house 2-246 (249) alignment 
Range on Protein: 1407-1649
Range on HMM: 2-246/249.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP
......|..||.|||| ....||||||.|....|  .||||||.|.|||......||||||||||..|||||.||... .|||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDA
..|. .|| ..||||...... ..|||. |.... .|.|.|...|.| |||||||... ..|.|...|....   |. ||..|||||||||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||... |..||..  | |.||||...||...|| |..||||| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 1682-1940 6.8e-92 302.9 In-house 4-262 (263) alignment 
Range on Protein: 1682-1940
Range on HMM: 4-262/263.0
LEFKRLANSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||...|.|.|.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1682-1940 6.8e-92 302.9 In-house 4-262 (263) alignment 
Range on Protein: 1682-1940
Range on HMM: 4-262/263.0
LEFKRLANSKAHTsRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTK
 ||..| .|. .. .. .|. . || |||  ||.||..||| |... . ||||||||..|.|....|.|||||||| .| |||||| ||....|.||||.
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LREMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPISV
  | |.|||..||| |  .. ..... |  . . ... ..|||....|   . ..|.|.|.|...||..|||.| . ..... .|.|.|..   .||| |
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||||||||.|.|..|.|.... |  ||||..||.||.||| ||||...|.|.|.|.|||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0042113 (Phosphotyrosine protein) phosphatases II 1409-1647 2.3e-91 300.8 In-house 2-241 (245) alignment 
Range on Protein: 1409-1647
Range on HMM: 2-241/245.0
EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR
....|..||.|||| ....|||.||.|.|..| ..||||||.||||||. . .||||||||||..|||||.||... ||||.|..||..|.||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP-PDAGPIVVHCSAGVGRTGCFIVIDAMLE
.. ||| ..||||..  |....|||......|..|.|||...... |||||||...  .| ||..|...   .. ||..|||||||||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
... |..|...  |  .||||  .|||..|| |..|||||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1379-1649 7.9e-91 299.0 In-house 3-276 (281) alignment 
Range on Protein: 1379-1649
Range on HMM: 3-276/281.0
AEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWR
 .|...|..||.  . .|||..   |.. | . |. . |. |||| |..|||..|| ..| |  . .||||||.|.||. ...|||||||.|... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLhKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT
|||||.  .|||.||  |....|| .|||.   . .|| ..|. . . | ||.  |.|.| .. |.|.|||.|...|||||||||. .. .| | . |. 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

CNPPDA-GPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.. ..   |.|.||||||||||..| .| ...... | ...||   |. .| .||.||||  ||.|.. |.|.|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045098 (Phosphotyrosine protein) phosphatases II 1394-1652 1e-90 299.1 In-house 11-275 (278) alignment 
Range on Protein: 1394-1652
Range on HMM: 11-275/278.0
SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVIlqpiegimgsDYINANYVDGYrcQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL
.. .. . .|.  ........ |..|||| ....||||||.          |||||.|.|||  ....||||||||.|. |||||.||... .|||.|.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKN----GSSEKREVRQFQFTAWPDHGVPEYP--TPFLAFLRRVKTCNP--------
.|..|.||.||||..|..||| ..||||.. .| ....||. ..       . |.|.|...... |||||||..|  ..|| .|.... ..         
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----PDAGPIVVHCSAGVGRTGCFIVIDAMLERIkpEKTVDVYGHVTLMRSQRNY-MVQTEDQYSFIHEALLEAVGCG
     .. ||..|||||||||||...... |||..  |..||..  |. .||||.. .||...|| |..|.||| . .|
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0040439 (Phosphotyrosine protein) phosphatases II 1698-1940 1e-90 299.0 In-house 4-246 (249) alignment 
Range on Protein: 1698-1940
Range on HMM: 4-246/249.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
  |.||.|| ||| ..|.||...||.|....|...|||||||.||||......||||||| ||.|||||||||...|..||||.| |.|||||.|||| .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVL
 |  |  |.|  . .. .. |..|....|.  ||.||||...|.||||..|||.| | ..||| .|.|  |. ...||. |||||||||||.||.. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|....|. ||....||.||.||| .||... |.|.|.|.||.|
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1407-1669 9.9e-90 295.9 In-house 16-275 (284) alignment 
Range on Protein: 1407-1669
Range on HMM: 16-275/284.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTrleeksRIKCDQYWP
. ...||. || |||. ...|.|...| |... |. .|||||| .. ||. .. ||||||||..|  |||||.||....|||..|      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN--PPDAGPIVVHCSAGVGRTGCFIVID
... ....  .| .    | . . || . | ..|   ..|..||| |  |||.|||.||.........|.  .    .  .||||||||||||| .||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

AMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
..|.|.| || ||||  |  .| ||| .||   || ||. ||||    |...|    . ||...|.
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_PTPRB_pd Subfamily PTPRB 1679-1940 2.3e-89 294.3 In-house 26-285 (293) alignment 
Range on Protein: 1679-1940
Range on HMM: 26-285/293.0
GMELEFKRLANSKAHtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
..  |...| . . .     .|.|..|. |||  ||.||. .|| |..... .|||||||..|.||.... .||||||| ||..|||||.||..|.|.||
rfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS
||.| | |..||..||||. ..  |    |. .|| .. ....||.|..   . ..|.|||..|| ||. |||.. . ..||. .|....|.  ...|| 
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||||||||||.||.|  .|.... | .|||| .|  ||..|  .||||..| | .|. |..|
vhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
Y_phosphatase Protein-tyrosine phosphatase 1416-1647 1.2e-88 291.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 1416-1647
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILqpiEGIMG-SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTET
|| |||| ....||..|| |   .|  | |||||||||.||. ....|||||||..|..|||||||.... .|||.|.||||.| ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTI-ELATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI
|| |.|.|  ..  . . ...|...|.|.... |||||.|...|.|||||||| |...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
. |..|||.  |  .|.||. |||...|| |...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1416-1647 1.2e-88 291.9 In-house 1-235 (235) alignment 
Range on Protein: 1416-1647
Range on HMM: 1-235/235.0
NKPKNRYANVIAYDHSRVILqpiEGIMG-SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTET
|| |||| ....||..|| |   .|  | |||||||||.||. ....|||||||..|..|||||||.... .|||.|.||||.| ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFIQVTLL-DTI-ELATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI
|| |.|.|  ..  . . ...|...|.|.... |||||.|...|.|||||||| |...| ..|.|.. . .. ||.||||||||||||.|...|..||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
. |..|||.  |  .|.||. |||...|| |...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Ptp69D_pd Subfamily Ptp69D 1371-1669 1e-87 289.1 In-house 2-306 (307) alignment 
Range on Protein: 1371-1669
Range on HMM: 2-306/307.0
PPIPIADMAEHTERLKANDSLKLSQEYESID-PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLP
..|.| |..|  .  | .    | .|||..     . . . |. . |. |||| ...|.|. ||.|..|.|   ||||||... ||. .. .|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-----SSEKREVRQFQFTAWPDHGVPEYP
.| ||||||..|| . .|||.. |.||.| ||..|||.  .  || | |.| .. .   .  |.... |..       ..|.| |...|.|.|  ||| .
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
.  | ....|.  .  . .||||||||||||.| |. .| .|...| |..||..  |  .||||| .||  .||.|.. |||.    |.|..  ..|   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

IQKLA
|..|.
ierlc
subfamily_PTPRG_pd Subfamily PTPRG 1678-1942 1.6e-87 289.0 In-house 19-289 (563) alignment 
Range on Protein: 1678-1942
Range on HMM: 19-289/563.0
TGMELEFKRLANSKAHT-SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS-DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
.|.. ||. | .  ...     ... |.|| ||| .||..|...|| |.|. |.... |||||..||||...||.|||||||..|..|||||.||.|..|
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.||.|.| | ||.||..|||.. | .|. . |  ..|     |.. . .....|. . ..  . ..|||...|.||..|||..    . |. .  .....
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

fgQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
  . ||| |||||||||||..| |. .|.... | .|..|...|..|.||. .||||..|.| ..| || . |
..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN9_pd Subfamily PTPN9 1665-1940 2.5e-87 287.7 In-house 3-290 (297) alignment 
Range on Protein: 1665-1940
Range on HMM: 3-290/297.0
IQKLAQVEPGEHVTGMELEFKRLANSkAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDF
|..| .    ..  |.  |.. . |  . . .|  ..|..|  |||  ... |..||| |. . . | ||||||.|.|||.|.||.||||||| .|..||
ieelvayvkekgkrGlskeyaeirne.pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQ
|||.||..  ..|| |.. |.|| || ||||   | ||..  . |  .   .. .|  | ..........||.|  |||. ||. |||.|.. ..|.. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
| ... ..            .. || ||||||.|||| |||| | |.|.. .|.||...|||.|||||  ..||.. |.|||.| ||| 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1677-1944 5.2e-87 286.8 In-house 21-287 (305) alignment 
Range on Protein: 1677-1944
Range on HMM: 21-287/305.0
VTGMELEFKRLANSkaHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV
 .|.| ..| |..   ..| ..  .   || ||||..|....  |. |..   .. |||||||..|||...|.||..|||| .| .||||...|   . .
dkgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQD
||||||.| |..||.|||| . .   ... |.|    | ....|| |..|..    | .|||| |.|.||||..|||..   ....| .|.|.... ...
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkg

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
 |. ||||||||||||||...| |||.. |.|||.|. .| ||..|. |||| |.|.|...|  |.. ..|
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0045098 (Phosphotyrosine protein) phosphatases II 1693-1941 1.6e-86 285.4 In-house 21-273 (278) alignment 
Range on Protein: 1693-1941
Range on HMM: 21-273/278.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVClqpirgvegsDYINASFIDGYrqQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
. |..  |....|. ||| ..|.||...||.          ||||||.||||  .|..||||||| .|..||||||||...|..||||.| |.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA----RDGQSRTVRQFQFTDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQDGP
||| . | .|  |.|  . |.... |.|| ..||.      |..||.|...... ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ISVHCSAGVGRTGVFITLSIVLERMryEGVVDIFQTVKMLRTQRPA-MVQTEDEYQFCYQAALEYLG
. |||||||||||... . ..||..  ||.||....||.||.|||  .||... |.|.|...||.| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN9_pd Subfamily PTPN9 1385-1647 3.1e-86 284.1 In-house 10-288 (297) alignment 
Range on Protein: 1385-1647
Range on HMM: 10-288/297.0
LKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR
.|...   ||.||. |     . | ..|.| .|  ||||..|. ||..|| |. ...   |||||||.||||. ..|.|||||||..|. |||||||||.
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

SATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----
  .|||.||..|. |.|| ||||  .  .. .|...|. ... |   . ||.. ...   .|.|.|  |||..|||.|||.  . .| .|. |.      
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala

---------NPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
          .|.  |||||||||.|||| || .|  |.|.. . ||||   | |.|.|| ...||..|| | . |.||
vkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0042113 (Phosphotyrosine protein) phosphatases II 1700-1940 4.1e-86 283.6 In-house 4-243 (245) alignment 
Range on Protein: 1700-1940
Range on HMM: 4-243/245.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS
|.||.|| ||| ..|.||..|||.|.|. | ..|||||||..||||. . .|||||||.||.|||||||||...|..||||.. |.||.||.|||| . |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLER
 .|  |.|  . |.... |..|...||. .|..||.|.......||..||| . | ..||.  |.|  .. ...||. |||||||||||.||.. ..||.
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
...|. |.....||.|| ||| .|||.. |.|.|.|.||.|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1701-1947 1.7e-85 281.3 In-house 5-249 (250) alignment 
Range on Protein: 1701-1947
Range on HMM: 5-249/250.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREkCHQYWPAERSA
. | || |||  .|....|.|| |.. .| . ||||||||..||...||.||||||| .|.||||||..|..|. .||||.|.|.... .|||||.|.. 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM
.|    |... . ..  |. |..|.. |.  ..|.|||..|. ||..|||.  .  .... .|.....|  ...|. |.|||||||.| ||... ||||.
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavlerl

RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
. | |||.|. .|.||..|| .|.... | |.|...|..| |.. ||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1675-1939 3e-85 281.4 In-house 31-291 (319) alignment 
Range on Protein: 1675-1939
Range on HMM: 31-291/319.0
EHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
...| .| ||.|...  .  .    |||. || |||..||.... ..| |... |.|.||||||||..||.... |||.|||| .| .|||||.|| |..
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

IVVMLTklremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD
 .|.||      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . | ..|| |  ||..|||...  .. .. .|.. ...  . 
tivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE-Y
 .| ||||||||||||.|.| ..|.||. |  ||....|. || ||. .||   .|.|.| | || .
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
Y_phosphatase Protein-tyrosine phosphatase 1705-1938 3.7e-84 277.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 1705-1938
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
... |. ||..|.||.||.||| |||....|.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1705-1938 3.7e-84 277.2 In-house 1-235 (235) alignment 
Range on Protein: 1705-1938
Range on HMM: 1-235/235.0
NKFKNRLVNIMPYESTRVCLqpiRGVEG-SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP--AERSAR
|| |||  .|.||..||| |   .| || ||||||....||...|..||||||| .| ||||||.|.......||||.| |.|||||.||||   |.| .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYFVVDPM-AEY-NMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPISVHCSAGVGRTGVFITLSIVLE
|. . |  .  |  .. .|.||......  .  ..|.|.|...|.||..|||.| ....|.| .|.|.|    ..||. |||||||||||.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
... |. ||..|.||.||.||| |||....|.|.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1676-1937 1.1e-83 275.7 In-house 19-276 (288) alignment 
Range on Protein: 1676-1937
Range on HMM: 19-276/288.0
HVTGMELEFKRLANSKAHTSRFIsANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
  ||.. |.. ||. . . |  . ..|. |. |||  ||.||. .|| |.    ..|.||||||.|||....|.|||||||||.| .|||.. .||... 
nrtgfseeynsLaalektksvta.grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

VVMLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDG
.||||.| | |..||..|||..    .|  . |  . . .. ...||.. .   .... ... |.|.. ||..|||.| . ..... ||. ....    |
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tg

PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
|| |||||||||||.||.|  ...... | ..|.. ||. || ||. .|||.  |.|.|.. |
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRK_pd Subfamily PTPRK 1697-1938 2e-83 274.8 In-house 35-275 (314) alignment 
Range on Protein: 1697-1938
Range on HMM: 35-275/314.0
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA
. .|.   |. |||  .|..|. .|| |..| |   ||||||..||.|.. .|.|.||||| ||..||||.....|.. .||||.| | || || .||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

ERSArYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPISVHCSAGVGRTGVFITLS
. .  |. . |  .      ... | |.|. .     . |.||||||. ||. .||.| .|..... .|.|..|.  ..|.| |||||| ||||.||...
dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaid

IVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
|||. .. |||||.|..|| ||.... ||.||. |.|.|...||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Ptp69D_pd Subfamily Ptp69D 1678-1940 2.4e-83 274.8 In-house 22-286 (307) alignment 
Range on Protein: 1678-1940
Range on HMM: 22-286/307.0
TGMELEFKRLANSKAHTSRFiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVV
 |.. |...| ... . |    ..   |..|||  .|.....||| |..| | | ||||||||| ||...| .|| |.|. .| .|||||..| ..|..|
fglakeyekLeareidkstk.vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-----GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFgq
||..| |. |.||..||| |   .|.  .|... | ....|| ||..|.   .      .|| | |...| |..  ||.. .| ...| ||.. ...   
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .|| |||||||||.|.|..|...|.... |  ||||.||| || ||. .||  . |.|.|.| |.| 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1681-1939 5.1e-83 273.8 In-house 1-255 (284) alignment 
Range on Protein: 1681-1939
Range on HMM: 1-255/284.0
ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT
| ||.|...  . ..    |||. || |||...|.... ..| |... |.|.||||||||| ||.... |||||||| .| .|||||.|| |.. .|.||
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

klremgREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTD-ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVH
      ..|| |||| .   ... | |.  .  .  .|..|...... ..  . |..||| |  ||..|||...  .. .. .|.. ...  .  .| ||
......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE-Y
||||||||||.|.| ..|.||. |  ||....|. || ||. .||   .|.|.| | || .
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPN6_pd Subfamily PTPN6 1661-1940 5.3e-83 273.5 In-house 9-297 (306) alignment 
Range on Protein: 1661-1940
Range on HMM: 9-297/306.0
LYAYIQKLAQVEPGEHVTGMELEFKRLANS--KAHTSRfISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGY--RQQKAYIATQGP
.   ...| . |   . .|.| ||..| ..  |   ||   .. | || |||  ||.|.. ||| |.   .| |||||||..|..    ..|.|||||| 
ieqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgc

LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGE
| .| .|||||.|..||...||.||  | |.||| .|||.| . . |    |  ..| .. .|||||..|.   .....|.|.|..|..||..||||. .
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpg

GFIDFIGQVHKTKEQFG--QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ..||. .|.. .|..   . ||| ||||||.|||| || . |.|. ....|.   .|| ..||..|.||  .||||. |.| |.|  .|.
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN6_pd Subfamily PTPN6 1389-1647 9.7e-83 272.7 In-house 24-295 (306) alignment 
Range on Protein: 1389-1647
Range on HMM: 24-295/306.0
DSLKLSQEYESI---DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGY--RCQNAYIATQGPLPETFGDFWRMVWEQR
.   ...|.|..   .  .... ....   || |||| |.. .||.||||.  ....|||||||||...     ...|||||| |..|  |||||||.. 
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SATIVMMTRLEEKSRIKCDQYWPNRGT-ETYGFIQVTLLDTIELATFCVRTFSL-HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----
|  |||.|.  |... || .|||.  . |.|| |.|| ..  .||.. .|..|. .|. ..|.|||.|..|..|||||||. |  .|.||. |..     
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

NPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE---KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.  .|||||||||||.|||| |||||..|. |. .     .|..  | ..|.||. .||||.|| |...|. .
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
0037934 (Phosphotyrosine protein) phosphatases II 1408-1647 4.2e-81 267.3 In-house 2-240 (243) alignment 
Range on Protein: 1408-1647
Range on HMM: 2-240/243.0
WEHSNLEVNKPKNRYANVIAYDHSRVILqpiEGimgSDYINANYVDGYRcqNaYIATQGPLPETFGD----FWRMVWEQRSATIVMMTRLEEKSRIKCDQ
. ...|..|..|||| ....||||||.|   ||   |||||||......  . .||||||||||. |    ||||.||... .|||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnrGTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--------NPPDAGPIVVHCSAGVG
|||  |..||| ..||||.. .|. ..|||..|   . . ..|.|.......|||||||. |...|.||. |...        . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCFIVIDAMLERIkpekTVDVYGHVTLMRSQRNY-MVQTEDQYSFIHEALLE
|||..|... ||...    .||..  | |.|.||.. .|||..|| |..|||||
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1372-1686 7.5e-81 266.4 In-house 2-314 (315) alignment 
Range on Protein: 1372-1686
Range on HMM: 2-314/315.0
PIPIADMAEHTErlKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|||.|..    .  |   .  .|.|.  .   . .    .  ..| .|||| |.. .|..||.|. |. .  |||||| |. .. ...||||.||||. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFsLHKNgSSEKREVRQFQFTAWPDHGVPEYPTPFLA
  ||||||.... .||||.| ..|  .||| ||||.| ..   .| |.|.||..   .   .| .   .. | |.| | ||||| |||.||..  . .| 
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk.seesrtvtqfqftewPdkGvdkqtssllk

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
... ||. | ..  ...||||||||||| .| || ....|| ...|||.  |. .|..| |.||||..|.||..|.|| .   || ..   .  ..| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

QVEPGEHVTGMELEFKR
    |.  . |  ||..
tsvdgsgrskmtkefet
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1372-1688 1e-79 263.0 In-house 1-315 (515) alignment 
Range on Protein: 1372-1688
Range on HMM: 1-315/515.0
PIPIADMAEHTErlKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|.|.|..    .  |..    .|.|.  .   . .    .. |.| .|||| |.. || .||.|. |.    |||.|| |. .. ...||||.|||.. .
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

FGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--TYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPTPFLA
  ||||.|.... .||.|.|.|.|  .||| .|||.. ..   .| |.| |. .   .    |.. . |.     | | ||.|| |||.|||.  . .| 
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllk

FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA
... ||. .   . |...|||||||||| .| || .. ..|  ..|||.  || .| .| |.|||..||.||..|.|| .   || .|   .  ..| | 
likevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

QVEPGEHVTGMELEFKRLA
    |.  . |  ||. | 
ssgdgrgrskmtkefqtlk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1678-1946 1.3e-79 262.1 In-house 20-289 (290) alignment 
Range on Protein: 1678-1946
Range on HMM: 20-289/290.0
TGMELEFKRLANSKAHTSrFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTI
.|.. .||.| ... . .    .. . || .||  ||..|.  |. |.|| | .    .||||..|.||...|.|||||||. .|  |||...|....||
egfrnqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvti

VVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDG
.||||.  |.|..||.||||.. ...|..| .  . | .. .|| |...|.. .  |....| |.|.| |...|  .  .. .  | .. ||. . | ..
ivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.nt

PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
.| ||||..|||..||... . ..... |||.|.|| .| .|.|.| .|||...||. .|  |.|| ||. |
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN12_pd Subfamily PTPN12 1392-1649 9.2e-79 259.3 In-house 16-277 (290) alignment 
Range on Protein: 1392-1649
Range on HMM: 16-277/290.0
KLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMT
|| .. |     .... |... |.|. |||| ... ||.||| |. ||.  ||||||||.. |   . .|||.|||||.|  |||||.||..   .||. 
klkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC

RLEEKSRIKCDQYWPNRGTET--YGFIQVTLLDTIELA-TFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVH
|. |  ..||..|||..| |.  .| ..||| .   .   | .||. ....  .|.|.|.||..|||||||||. ... |.... |.. .  .. |.|||
revelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh

CSAGVGRTGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||||||||  |.|| . | .| ||.   .||.  |. .| ||. .|||..||.....|..| |
CsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN12_pd Subfamily PTPN12 1696-1940 2.9e-78 257.7 In-house 31-277 (290) alignment 
Range on Protein: 1696-1940
Range on HMM: 31-277/290.0
RFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP
.  ... . |. |||  .|.||. .|| |. |...||||||||.|| |  ....|||.||||..| .|||||.|| | .||||. .. |.|. ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

AE--RSARYQYFVVDPMAEYNMP-QYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFIT
 |  .. ... | |. ..| ..  ....| .||.    ..||.|.||..|.||..|||.| .  ...| .|....|   .| |. |||||||||||. |.
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
. .| | .. | .   .|.|. |  ||.||.|.|||.. |.. |.| .|..
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0037934 (Phosphotyrosine protein) phosphatases II 1699-1940 2.1e-77 255.2 In-house 4-242 (243) alignment 
Range on Protein: 1699-1940
Range on HMM: 4-242/243.0
SANLPCNKFKNRLVNIMPYESTRVCLqpirgvEGSDYINASFIDGYRQqkaYIATQGPLAETTED----FWRMLWENNSTIVVMLTKLREMGREKCHQYW
 |.||.|. |||  .|.||. .||.|      ||||||||..|.....   .||||||| ||.||    |||||||...|..||||.| |.|||||.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PaeRSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQDGPISVHCSAGVGRT
|   . .|  |.|  . |.....|..|.....    |...|.|...... ||..||| | | ..||. .|..  |.        ..||. ||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFITLSIVLERMryeGvVDIFQTVKMLRTQRPA-MVQTEDEYQFCYQAALEYL
|..|.. ..|...   | ||....||.||.|||  .|||.. |.|.|.|.||.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1373-1684 3.8e-77 254.6 In-house 5-323 (325) alignment 
Range on Protein: 1373-1684
Range on HMM: 5-323/325.0
IPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETF
| . .. || |. ||.|   ...|.. . . .  . . . .  || |||. ||.|.|.|||.|.  .    ||||||.|.  .. .. ..|.| ||..| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

GDFWRMVWEQRSATIVMMTRLEEKsRIKCDQYWPNR--GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAF
.|.||.| . |.. .|..  |...   .| .|||..   . |.| ..| |    |.. .  | . . .    | | |.|||. .|.| ||...|. ....
ndlWrlvldWrcsvvvvlneldlg.kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRRVKT------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY
|. ||.      .|   ..||.||||||||||| || . ..|...  |  ||..| |  .| .|  ||.| |||..|.||| ||. .|||.||  |. | 
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IQKLAQVEPGEHVTGMELEF
.  | . .|  .   .| ||
lsslqernpltqklniekef
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1414-1648 8.4e-77 252.5 In-house 5-239 (239) alignment 
Range on Protein: 1414-1648
Range on HMM: 5-239/239.0
EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrGTET
 ||| ||||||...||||||.|. .     ||||||.|.  |    .||||||| .  . ||||||.|..| . |||.| | |  . || ||||.  |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsk

YGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE
|  ..|||  |  .| . .||| . . | .|.| | |..|| |||.|||.| |  | . |..   . | | | |.||||||||||.|.|||||| . | .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
||||.. .|  .| .| .|||| .|| ||| |.|||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1413-1647 2.2e-76 251.1 In-house 5-239 (239) alignment 
Range on Protein: 1413-1647
Range on HMM: 5-239/239.0
LEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrGTE
  ||| ||||||...||||||.|. .     ||||||.|.  |    .||||||| .  . ||||||.|..| . |||.| | |  . || ||||.  | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.sts

TYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKP
 |  ..|||  |  .| . .||| . . | .|.| | |..|| |||.|||.| |  | . |..   . | | | |.||||||||||.|.|||||| . | 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.||||.. .|  .| .| .|||| .|| ||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1675-1940 3.3e-76 251.1 In-house 12-276 (281) alignment 
Range on Protein: 1675-1940
Range on HMM: 12-276/281.0
EHVTGMELEFKRLANSK-AHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS
.. .|.  |.. ||.    .|..  ... . |. ||| .||. |. ||| ..|    . .|||||.|..||...|.|||||||. .. ..||.|.||.. 
ndnaGfieeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

TIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQYILREFKVtDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ
...||.|.  | |. |||.||| .. . .|  ..|  .|| . ..|| |.||. ....|..|.|.|...| ||..|||.. . ...|  .|.|..|.  .
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

dGPISVHCSAGVGRTGVFITLSIVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
  |. .||||||||||..|.|  .....   .  .|. ..|. || .|  ||||   |.| |.| |..|
.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1373-1651 1.5e-75 248.8 In-house 2-285 (290) alignment 
Range on Protein: 1373-1651
Range on HMM: 2-285/290.0
IPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLP
||. ...|...  .|.   .  ......| |. ..| .. . . ||..||.||.. ||  |..|.|| |      .|||| |..||. ...|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS-SEKREVRQFQFTAWPDHG-VPEYPTPF
.|  |||...|..... |||.|   |. . || ||||...|..|| ....||.  .| ..  |....... |  .|..| |.|.|.|...| |... |  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC
|.. ...||   .  ..||||||..|||.. |....  ... | |  .||.  .  .|.|.  .|||..|| .|.. .|... .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1371-1659 2.1e-75 248.6 In-house 8-294 (297) alignment 
Range on Protein: 1371-1659
Range on HMM: 8-294/297.0
PPIPIADMAEHTERLKANDslKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCqnAYIATQGPLPE
 |||..|.|   .. .  |    |.|.  .   . ..   ..  || .|.||.|.. || |||.|. ..    |||.|| .| |..    .|.|| | ..
rpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPE--YPTPFL
|  |||.||.... .||||.. ..|. . || .||...|. |.| . |.|| . |   |  |.... |. .  .| |.|.||. |||. |..    . .|
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

AFLRRVKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPAR
 ..  |.      |  |..|||.||||||| .. || .. ..| ||.||..| |. .| .| |.|||..||.|...|.|||. . .|...| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_PTPN3_pd Subfamily PTPN3 1406-1648 2.1e-75 248.2 In-house 31-274 (280) alignment 
Range on Protein: 1406-1648
Range on HMM: 31-274/280.0
FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgiMgsDYINANYVD----GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC
 . .....  | .|||| ....||. ||.|.  |     ||||||||.    .    | ||||||||..|  |||.|||||.| .|||.| | |. |.||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DQYWPNRG-TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI
 ||||. . . .|| ..|..  . |  ....| . |... ..|.|.. |.|..||||||||. .. || |..||...   .  |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
...  |  |  .. | .   |  || ||  .|||..|| |. ||.|..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN13_pd Subfamily PTPN13 1409-1649 3.1e-75 247.9 In-house 30-269 (273) alignment 
Range on Protein: 1409-1649
Range on HMM: 30-269/273.0
EHSNLEVNKPKNRYANVIAYDHSRVILQPIEGimgsdYINANYVDGYRCQN--AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP
| .. . || |||| ||. ||..||.|.   |     ||||...     ..   |||.|||||||  |||.|||||..  |.|.|   || ..||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

NRGTE---TYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPpDAGPIVVHCSAGVGRTGCFIVID
..  .    .. ..|.||.. .| .| ||.. .... |.| ||| ...|..|||||||  ....| |...|.. .  ||||||||||||.||.| .|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

AMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
..|. |. .| .||   |  .| ||. .|||.||| |...|.||..
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1704-1940 7.3e-74 243.7 In-house 42-276 (515) alignment 
Range on Protein: 1704-1940
Range on HMM: 42-276/515.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSAR
 |  |||  ||.||.|.|| |. |     |||.|||.| ..  .|||||.|||.  ...||||.....| | ..|.|||.|  . || .|||     | .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLERMR
. .. |. ..     . | |...|.   |  |||| ||.||.||..||||    .. .| .|   ..|.    |. .|||||||||||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
   .||.|..|. .| .|| .|||...| | |.| ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1392-1647 1.7e-73 242.1 In-house 6-266 (274) alignment 
Range on Protein: 1392-1647
Range on HMM: 6-266/274.0
KLSQEYESIdPgQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMG-SDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVM
.| .|. .. |   |. |. ..  .. |||| ...  ..|||.|.. ..    |.||||||. ||.  ..||.|||||||.|  |||||......  |||
dlekeflel.P.lnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

MTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP---PDA
.|.|.|. . || .|.|..     .|.|| ....  ...|   . ||...|..  .  .|.|  . .|.|||| .|. ....| ... |.. .      .
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.|.|||||||.||||||| |.  . ... |..||| . |. .| .|  ||||..|| .||.|| .
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1679-1947 2.9e-73 241.4 In-house 21-285 (287) alignment 
Range on Protein: 1679-1947
Range on HMM: 21-285/287.0
GMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
| .  |. | . . .      .  . || |||| .|....  || |.     |  |||||.|||||...||.|....|...|  .||......| |..||
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivm

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDAR-DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPIS
|....|  .|.|.|||| |.|  .  . .  . |  . .|| |...|.    .|. ..|.|.|.|.|...|  .. .  .  | .  ||. . | ...| 
lcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA
||||..|||...|.   . ... . |||.|.|| .|  | |.| .||| ..|.| ... |||| ||. |.
vhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN3_pd Subfamily PTPN3 1684-1937 1e-71 236.1 In-house 21-272 (280) alignment 
Range on Protein: 1684-1937
Range on HMM: 21-272/280.0
FKRLANsKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirGVEGsDYINASFI----DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|..|   |        |..| |  |||  .|.||..||| |.     |  |||||...    ..  . . |||||||||.|..|||.|.||..|...|||
feqlyr.kkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISV
| | | || ||||||| .  . .|  | |    | .  .|.|||. ..|..  ..|.. |.|...||..|||.. . |..|. .|.|...  |.. |. |
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvvv

HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
|||||.|||||.|.| . |  .  .  | . . |...| || ..|||.. |.|  .| |
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1673-1940 1.6e-71 235.8 In-house 14-277 (315) alignment 
Range on Protein: 1673-1940
Range on HMM: 14-277/315.0
PGEHVTGMELEFKRLANSKAhtSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENN
   |.. .  ||. | . ..  .|  .|  . |  |||  ||.|..|.|| |. |     |||||||.| .. ..|||||.||||  . .|||||.....
knrhtalfseefhdlpdPdi..yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqek

STIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQYILREFkVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQf
 | .||.||..|  . || ||||     |...  . |. .      . . |.. ||  .  .|||| |||||.||..||.|    .. .| .|   ... 
vttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk.

gQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .. .. ||||||||||||.|..  |..... . .||.|..||.||..|| .||||.|| | |.| ||.|
.kefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1377-1656 2.2e-71 235.6 In-house 6-286 (439) alignment 
Range on Protein: 1377-1656
Range on HMM: 6-286/439.0
DMAEHTERLKANDSLKLSQEYESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFG
.. || |.|. |.   .....|.|.   |  .        | ...|||| .| |.||.||.|| | |.  | ||||||..||  .. |||||||  ||  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQRSATIVMMTRLEEKSRikcdqYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG--SSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
||||.|.|....||||.| | |  .     |||  .   || | |     |||  ...| | . ..   .  .| | ||...||||. ||   .  | ||
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
| ....|   . ||.||||||||||||  | .|  ||..| |. ||. | |...| ||. |||.  || ||..|.|| .  |.. |
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1413-1656 6.8e-71 233.6 In-house 44-285 (287) alignment 
Range on Protein: 1413-1656
Range on HMM: 44-285/287.0
LEVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET
 . ||.|||..... .|  ||.|.        ||||| ..|||. ..|.|....|. .|  .||.......  .|||.....|. . .| ||||.  . .
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvv

YGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHG-VPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIK
.|  ...||.    | . .|.. ..... ...|..|.|.|.|.|...| |.|. | .| . ...||   .  ..||||||..|||.. |. ..  ... |
lGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
 | ..||.  .  .| |.  .||| .|| || ...|| . ...| .
teGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1701-1941 9.9e-71 233.0 In-house 24-269 (274) alignment 
Range on Protein: 1701-1941
Range on HMM: 24-269/274.0
NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER
... .. |||  .|.| | .||.|..  . .  |.|||| .| ||.. .|||.||||||..| .|||||.........||||||.|. ..||..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA----RYQYFVVDPMAEYNMPQYILREFKVTDARDgqSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD-GPISVHCSAGVGRTGVFITL
..    ||. . .      .  .| .|.. .  . .  .|.|  . .||||.. .|.. . ..|.. .|....|.  .  .|. ||||||.||||.||. 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG
|| . ..| |.|||....|  || .|  ||||.. |.. ..|  .|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1674-1944 3.3e-70 231.6 In-house 22-288 (297) alignment 
Range on Protein: 1674-1944
Range on HMM: 22-288/297.0
GEHVTGMELEFKRLANSKahTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQqkAYIATQGPLAETTEDFWRMLWENNS
. |.. .. ||. | ...  .     |.   |  |.|  ||.||.| || |. .     |||.||||. |...   .|.|| |  .| .|||.|..... 
nrhtdvfseeflclpean..iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqv

TIVVMLTKLREMGReKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK--SGEGFIDFIGQVHKTKEQFG
...|||... |  . || .||. . .. . . .|  ..  .   .| ||..||  .  . | |.|.||..||.. |..  | . ....| .|.|. .|  
stivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna

QDgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFD
.  |. |||.||||||||..|.  |. ... |  ||||..||.|| .|| .|||...|.| |.| ||.| | |
eg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1416-1647 6.6e-70 230.0 In-house 3-237 (237) alignment 
Range on Protein: 1416-1647
Range on HMM: 3-237/237.0
NKPKNRYANVIAYDHSRVILQPIEGimGSDYINANYVDGYRC-QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG-TETY
|| ||||.|..|||||||.|.   .  |||||||.|..|.    . |||.||||  .  |||.|||... . |||.| | |. ..|| .|||.    ..|
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GFIQVTLLDTIELATFCVRTFSLHKNGS-SEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIK
| . |.|    |.. . ||.. | |...  | | . |.|||.|||.|||.. . .| | ...   .|  ...|| ..|||||||||| |.|||||| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
 .| ||.| .|  .  .| |..||.||| |||...||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN1_pd Subfamily PTPN1 1403-1649 1.1e-69 229.4 In-house 19-271 (290) alignment 
Range on Protein: 1403-1649
Range on HMM: 19-271/290.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGimgsDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD
 ..|. ....|. |...||| .|  |||||..|.  .     |||||. |.  . .  || ||||||.| . ||.|||||.| ..||. .. ||..||| 
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWPNRGT-ETYG----FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT--CNPPDAGPIVVHCSAGVGR
||||.    ..       ..|.|. . .  .. ||.. |..  . | ||. .| .|.||| |||| |. || || .|.   .  .| || |.|||||.||
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGCFIVIDAMLERIKPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.| |...|..| .|. ..    ||.  ..  .|..|  ..|| ||  | . |.|| .
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_PTPN13_pd Subfamily PTPN13 1683-1942 2e-69 228.9 In-house 16-271 (273) alignment 
Range on Protein: 1683-1942
Range on HMM: 16-271/273.0
EFKRLANSKAHTSRFIsANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSdYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT
||| | . |.  .  . ..   || |||  |..||. ||| |.     ||. |||||.|      ..  |||.|||| ||..|||.|.|| ......|.|
efkelrelkpldtcev.gkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KLREMGREKCHQYWPAERSAR---YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPIS
. .| |. |||.||| ... .   .. . |. .   .. .. .|...|.| . |.|| | ...|..||. |||.| . .. |. .| . ..   . ||| 
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
||||||.||.|..||. .||. .  .  .|. ..|. || || ..|||.| | |.|.|.|| |.|
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPN14_pd Subfamily PTPN14 1682-1940 1.6e-67 222.6 In-house 27-296 (300) alignment 
Range on Protein: 1682-1940
Range on HMM: 27-296/300.0
LEFKRLANSKAhTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVeGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
 |. |... ..  . . .|.|| |. |||  ...||| .|| |.| .    ..||||| |      ... ||..||||  | .|||.|.||.. ...|||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TKLREMGREKCHQYWPAE----RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
|. .| |.||...|.| .    ...... | |      . ...| . .|.     .. |||  .|.||||..|||.  .||.... .|.  .... .   
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
    . |. |||||||||||| |.  .... .  . ..|| .....||.||  .|||   |.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN23_pd Subfamily PTPN23 1674-1939 2e-67 222.0 In-house 11-279 (288) alignment 
Range on Protein: 1674-1939
Range on HMM: 11-279/288.0
GEHVTGMELEFKRLANSKAHTSRFISAN-LPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQ-KAYIATQGPLAETTEDFWRMLWEN
 . .|... .|| | ..... .|  |     ..  |||  .|.||...||.|.     .  |||||||. .   .   .||||.||..|  |||.|..|.
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

NSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK--TK
 | ..|||..  |.|..|...|||... .  ... . |    . ...... |..|..  .  . ..|.  |.| ||| |||.| | ...|...|..  ..
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

EQFGQDGPISVHCSAGVGRTGVFI-TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
.|   . |. |||||||||||||    ..| |  . .|..|| | |. ||.||  |||......|.|.| ||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1695-1941 2.2e-67 222.5 In-house 38-289 (325) alignment 
Range on Protein: 1695-1941
Range on HMM: 38-289/325.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLrEMGREKCHQYW
  .  | .| || |||. |..... .||.|.  .    |||||||..  ..... ..|.| ||..|..|.||.. . ....||.| .| . | ..| .||
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavyw

PAE--RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ----DGPISVHCSAGVGRTG
| |   | ..  . |  ..  ..  |. | ..| ....|..|.|.|||.  |.. ||.|    .| ..  |.. .|.        .|| |||||||||||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG
|||.|  .|...  |  ||||. || || .||.||.| |.| ..|.|  |.. 
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1685-1940 1.9e-66 218.8 In-house 2-264 (270) alignment 
Range on Protein: 1685-1940
Range on HMM: 2-264/270.0
KRLANSKAHTSRFisANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ-QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLR
|.| . ....| .   .   .|  ||  .|.|   |||.|....  . . |||| .. |. . .|.|||..|||. |...||||.||...| .||.|.| 
keldkeetsesdl..peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EMGREKCHQYWPAERSA--RYQYF--VVDPMAEYNMPQYILREFKVTdaRDGQSRTVRQFQFTDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQD
| ||.|| .|||||.    ....    |  ..| ..  |||.. ...  ..|..| .  |....||..|||.. .        .  . .|....... . 
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.|. |||||||||||..|.| |... .  .. ||. . .. || .|.|.||. ..|.| |.| .|| 
ePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_CG7180_pd Subfamily CG7180 1705-1940 3.3e-66 218.0 In-house 42-290 (296) alignment 
Range on Protein: 1705-1940
Range on HMM: 42-290/296.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGReKCHQYWPAERSARYQY
|. ||| |...||. .|| |. . | | ||||||...|.. ..|.|| |..|  || ..|||.......  ||.|||  .. . ....||| .  ..|. 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

FVVDPMAEYNMPQYILREFKVTDA----------RDGQSRTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQDGPISVHCSAGVGRTGVF
..|. . | ....   |.||.|             . . |.|..||.| |.  . || | ...|... .|.. .|.     . ||. |..| |..|.||.
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
... . || .. |. ||.|. ||.|| .|| .|.. .||...|.  ||..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1700-1940 3.4e-66 218.3 In-house 44-279 (315) alignment 
Range on Protein: 1700-1940
Range on HMM: 44-279/315.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAErS
|.   || ||| .||..|. .|| |  .   ..|||.||.||||| ... |||.|||.... .||||...|.. . .||||.| |  ..|. .||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

ARYQYFVVDPMAEYNMPQYILREFKVTDarDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPISVHCSAGVGRTGVFITLSIVLER
  |  . |  . |    .|  | . |.   . . |.| |...| ||. ||||.   ....| .|.. ...    |.| ||||||||||| ||||. ||..
viyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldq

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
.  | ..|... .. .| .|  |||. ..||| |.| || .
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1414-1663 4.1e-66 217.7 In-house 31-280 (283) alignment 
Range on Protein: 1414-1663
Range on HMM: 31-280/283.0
EVNKPKNRYANVIAYDHSRVILQPIEGimgsDYINANYVD---GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
. ||.|||. .....|  || |..       ||||| ..     |. .. ||..|.|| .|  |||.||.... ..|||.|.| |  |||| ||||.||.
denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKR-EVRQFQFTAWPDHGvPEYPTPFLAFLRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLER
| ||   ||| .     .| .. . |..|.|...   .  .|.  | . | .. .   |  . .|..       ||||||||.|.|||. || . | .. 
edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkd

IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYA
.. |  |||.  |. || ||  .||| ||| ..||. ||   ||.|.. |  |..
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_CG7180_pd Subfamily CG7180 1415-1653 1.5e-64 212.5 In-house 41-294 (296) alignment 
Range on Protein: 1415-1653
Range on HMM: 41-294/296.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRiKCDQYWPNRGTETYG
 |. |||. .|. ||. ||.|. ..|   |||||| |||..  ...|| |..|  || ..|||.|... . ..|..|.  . .. .. .||||.. | ||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyg

FIQVTLLDTIELATFCVRTFSLHKN----------GSSEKREVRQFQFTAWPD-HGVPEYPTPFLAFLRRVKTC-----NPPDAGPIVVHCSAGVGRTGC
 | | .. . ..| .  ||| | |.           . |.| |..||.| |.  . ||   . .. ..|||..      . |. ||.||..| |..|.| 
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGN
.. ||| || .. |. |||.. |  .| .|. .|.. ..| .| . ||||| |. 
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1372-1693 1.6e-64 212.7 In-house 3-280 (392) alignment 
Range on Protein: 1372-1693
Range on HMM: 3-280/392.0
PIPIADMAEHTERlkANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPET
|||.|..    |.     |  ...|.  .   . .    .. |.|..|||| |.. || .||.|. |. |  |||.|| |.... ...||||.||| . .
pipvaqfpafvek..nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FGDFWRMVWEQRSATIVMMTRLEEKSrikcdqywpnrgtetygfiqvtlldtielatfcvrtfslhknGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFL
. ||||||.... .||.|.|.|.|                                               ..| | ||.|| |||..||.. . .| |.
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

RRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQV
. ||.     . |...||||||||||  | ||... . |  . |||.  || .| .| |||||..||.||. |.|| .   || .|   .  ..|.|   
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

EPGEHVTGMELEFKRLANSKAH
  |.  . .  ||. |  |.. 
sdGdvrskqlkefrslkashtv
subfamily_PTPRN_pd Subfamily PTPRN 1392-1649 3.4e-64 211.4 In-house 30-292 (297) alignment 
Range on Protein: 1392-1649
Range on HMM: 30-292/297.0
KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYV-DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV
.|..|.|..     .. | | .. | |  |||...|..|||||| |.       ||||||  . |    . |||||||||..|  |||.||||| .. ||
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV
..|||||..  .|..|||. |.|.|.. .| |. . |    . ||.| |    .|| | | || | .||..|||  . ..| | |.|  .    . ||||
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVGRTGCFIVIDAMLERI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|||.|.||||..|.|| .|.|. |  | .|.   .  .| ||. .|.|.||. |.  |. | |
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1415-1647 2.7e-63 208.5 In-house 19-262 (270) alignment 
Range on Protein: 1415-1647
Range on HMM: 19-262/270.0
VNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ-NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTE--
 .|  ||||...   ..||.|...|    . ||||||| |.  . ..|||..|||| |  .||||.||... .|||.| |||| | ||..|||..  |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--TYGFIQVTLLDTIELATFCVRTFSLHKNGSseKREVRQFQFTAWPDHGVPEYPT------PFLAFLRRV-KTCNPPD-AGPIVVHCSAGVGRTGCFIV
  ..|.|.|. | .     . ..   |...|.  .|..  |....|||||||. .         |. || | ....  | |.|..|||||||||||..|.
kledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
.| ... .. .| |||   .. .| .|  .||. .|| |...|..|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN23_pd Subfamily PTPN23 1414-1649 3.4e-63 208.2 In-house 41-280 (288) alignment 
Range on Protein: 1414-1649
Range on HMM: 41-280/288.0
EVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQ-NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG--T
...  |||. ... |||.|| |.        ||||| .| .   .   .||||.||..| .|||.||.||.| .|||..  ||. . |.|.|||..   |
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----NPPDAGPIVVHCSAGVGRTGCFIVIDAML
...| ..||| .. |. |.  |...|. ........|.  |.|.||..|||. |  .|.||  |...    . .   |.|||||||||||| | .. | .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ERIKPEK-TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
. .. ..  .|.   |  .| || .|||...|. |  || |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1403-1646 7.5e-63 207.0 In-house 25-274 (287) alignment 
Range on Protein: 1403-1646
Range on HMM: 25-274/287.0
GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD
.  .|.  ..   .  |||||.|. .|..||.|   || .|||||||||| .|. ..|.||.|||.. | .||||.|.|.|||....|||  |..| || 
sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPNRGTE-TYGFIQVTLLD-TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRV-----KTCNPPDAGPIVVHCSAGVGR
.|||.|      |   |.||| .|    ..||.. | .  . | | |.|... .|||....     .. |   |      . .  ..||.|||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
.| .. . ....| .    |||   |  .| .|. .||.  |. .. ||| 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1675-1946 8.5e-63 206.8 In-house 12-299 (301) alignment 
Range on Protein: 1675-1946
Range on HMM: 12-299/301.0
EHVTGMELEFKRLANSKAHTSRfISANlPCNKFKNRLVNIMPYESTRVCLQPIRG--VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENN
 | ...| ..|.| . . ...  .. .   ||  ||  || .|.  |. |.| .   .   .|||||.||||...|..||.|||. .|  ||||..|.. 
khsnkfeeqykelkegedksct.vgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

STIVVMLTKLREMGREKCHQYWPAERSARY--QYFVVDPMAEYNMPQYILREFKVT--D-------------ARDGQSRTVRQFQFTDWPEQGVPKSGEG
 . .||.|.|.|  ..||.||||  .  ..    | |  . |...|....|...|.  |              .| .|..| |.| ||||..|| .    
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

FIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
 .  | .| ... . |  ||. ||||..|.|.||....|| ||  . |||||.|| .| .| ..| .|.| . | . |..  .||   . |
vLqviddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_PTPN14_pd Subfamily PTPN14 1392-1647 8.5e-62 203.8 In-house 24-294 (300) alignment 
Range on Protein: 1392-1647
Range on HMM: 24-294/300.0
KLSQEYESIDPGQQ-FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGImGSDYINANYVDGYR--CQNAYIATQGPLPETFGDFWRMVWEQRSATIV
|. .||| | . ..  . . ..|..|..|||. .|. |...|| |.| .    ..||||  .       .  ||..||||. |  |||.|||||  . ||
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MMTRLEEKSRIKCDQYWPNRG----TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN------
|.|. ||. . |. .|.|. .    | ..|  .||   . .  ..  ... |.   |.|.|.|  .|.| |||||||| ...|| .|..|.         
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

-P--PDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
 .      |..|||||||||||  |. | ... .. ....|.   .. .| || ..|||  || |....|..
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPRN_pd Subfamily PTPRN 1680-1938 1.1e-61 203.1 In-house 31-290 (297) alignment 
Range on Protein: 1680-1938
Range on HMM: 31-290/297.0
MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI-DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
.| |.. |.. .|. |    |. . |  |||  ...||. .|| |.     | |||||||.| |   .. ||||||||||.|  |||.|.||. ....|.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNM-PQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIS
||.|.| | ..|..||| | |. |. . |. ..|.    .|..| | . . .  ..||| || |  |||.||| |   ...|  .| |.    |.  || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCSAGVGRTGVFITLSIVLERMRyEG--VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
||||.|.|||||.| . .||.|.   |   .||  |.. || ||| .|.|.|...|...|  |
vhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1705-1940 8.5e-61 200.7 In-house 48-279 (439) alignment 
Range on Protein: 1705-1940
Range on HMM: 48-279/439.0
NKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRekchqYWPAERSARYQY
.. |||  .. ... ||| || | ||  | |||| .|.|| ..| |||||||  |||.||||...|.... .||||.| |  .     |||..  . |  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygd

FVVDPMAEYNMPQYILREFKVTDARDG--QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
 .|    . ..|.|..| ||| . ||   . ||| ||... ||.. ||      .||.  .  ....  . ||. |||||||||||  |.| | ||... 
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|  |||   ||.|| ||  |||.  .| | |.| || .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1385-1654 4.3e-60 198.0 In-house 9-298 (301) alignment 
Range on Protein: 1385-1654
Range on HMM: 9-298/301.0
LKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ
  |. | |....|.... |.. . . .  | ||. ||. |.  ||. |.||.| .   ..  .||||.|.|||. ....||.|||. .|  ||||..|..
vaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

RSATIVMMTRLEEKSRIKCDQYWPNRG--TETYGFIQVTLLDTIELATFCVRTFSLH-KNGSS--------------EKREVRQFQFTAWPDHGV-PEYP
. ..|||.| |.|... || |||||    .|..|...||| ..  .  | .| .... ..||.              . ..| |.| | ||..|| .|. 
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNT
|   .    ... . .. ||.|||||..|.|.| .. ..  ||  | |  |||.. .  .| ..  .|.| .||..|.... . . . .|
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1700-1939 7.6e-60 197.2 In-house 28-265 (283) alignment 
Range on Protein: 1700-1939
Range on HMM: 28-265/283.0
ANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFID---GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA
|    || |||  .|.|..  || |..       |||||.||     |.|.| ||..|.|| .|  |||.|..... | .||||||.|  |.|| |||| 
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

ERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQDGPISVHCSAGVGRTGVFITLSI
. |  |  | |    |.    .| .|. .      .|   .  .|. || | |     . .. |  .| ... .  ..||| ||||.|.|||.|||..| 
rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkgPivvhCstgiGrtavfiaasa

VLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
 .. .. | |||.|..||..| ||. .||| | |.. ....|| 
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1680-1939 3.3e-59 195.0 In-house 12-276 (287) alignment 
Range on Protein: 1680-1939
Range on HMM: 12-276/287.0
MELEFKRLA-NSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
.. |...|  .|.. |  | .|.   .  |||  ...|.. ||| |    |  ||||||| .. .|....|.||.|||.| |  ||||...|..|. |..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LTKLREMGREKCHQYWPAERSA-RY-QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV--HK-TKEQFGQD
.|.  | .| ||..|||  .   |   | ||    .   |.|  | ... |.   ..| |.|... .||..... .  |.| |. .|  |   . .  . 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
||. ||...|.||.|..... ....|.   | ||. ..|  || .| |.||.   ... |.|   |
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPN1_pd Subfamily PTPN1 1691-1938 3.3e-59 195.0 In-house 18-269 (290) alignment 
Range on Protein: 1691-1938
Range on HMM: 18-269/290.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGvegsDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC
.|.  .  .|.|| |. .||  .. ||. .|. |.        ||||||...  . .. || |||||..|.. ||.|.||..|  |||| |. | .. ||
easdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

HQYWPAERS---ARYQ--YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVG
.|||| . .     ..   . |. ..| .  .|..| ..... .  ..|.. .| .| ||. |||.|   |..|. .| ..     . ||  .|||||.|
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
|.| |. .  .| ..  ..    ||| ...  || .|  ..|| |  .| |.| ||
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051429 (Phosphotyrosine protein) phosphatases II 1444-1669 1.8e-57 190.3 In-house 4-244 (272) alignment 
Range on Protein: 1444-1669
Range on HMM: 4-244/272.0
SDYINANYVDGYRC---QNAYIATQGPLPETFGDFWRMvWEQRSATIVMMTRLEEKSRIKCDQYWP------------NRGTETYGFIQVTLLDTIELAT
|.||||..|.||      .......|||| |  ||||. .|..  |||.....||. | |||.|||               | .||.. |||| .. |  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FCVRTFSLHKN-GSSEKREVRQFQFTAWPDHGVPEYPtpFLAFLRRVKTcnppdAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD--------VYG
. .|.. |..  . .| |||.....|.|||||||. .  .|..|. . .      ||..||||||..|||...... .|...  |  ||        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

HVTLMRSQRNYMVQTEDQYSFIHEALLEAvGCGNTEVPARSLYAYIQKLA
 |  .|.|| ..||||.|| |..|||||.  .. ..|.|. | |... . 
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1705-1938 1e-56 186.9 In-house 3-237 (237) alignment 
Range on Protein: 1705-1938
Range on HMM: 3-237/237.0
NKFKNRLVNIMPYESTRVCLQPIRGveGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSARY
|| |||  ||. |. .|| |.   .  |||||||....|.    | |||.||||  . .|||.|.|... ...|||| | |  ..|||.|||  .. | |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYFVVDPMAEYNMPQYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR
  . |    . .. .| .| . ..      . | . |.||| ||..|||.    .. |  .. .  .   . ||  .||||||||||.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
 . ||||.. |. .  .|| ..||.|.| | .|. ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0051429 (Phosphotyrosine protein) phosphatases II 1731-1942 1.3e-56 187.5 In-house 2-227 (272) alignment 
Range on Protein: 1731-1942
Range on HMM: 2-227/272.0
EGSDYINASFIDGYRQ---QKAYIATQGPLAETTEDFWRMlWENNSTIVVMLTKLREMGREKCHQYWP------------AERSARYQYFVVDPMAEYNM
. |.||||....|| .    .......|||  | .||||. .|.. . .|.|... |.||.||..|||            .. . .| ...|  . |...
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PQYILREFKVTDA-RDGQSRTVRQFQFTDWPEQGVPKSGegFIDFIGQVHKtkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD-------
. |||||. .|     |..|.|.....||||  |||..   ..... ....       .||. ||||||..|||... | ..|... .| .||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
 ....|..|| |||..||||. |.|.|.|.||.| |
yleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1698-1940 1.5e-56 186.5 In-house 38-236 (392) alignment 
Range on Protein: 1698-1940
Range on HMM: 38-236/392.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGrekchqywpae
 .|. . |. |||  ||.||.|.|| |. |  .  |||.|||.|... ..|||||.||| | . .|||||....| | ..|.|||.|             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

rsaryqyfvvdpmaeynmpqyilrefkvtdaRDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktKEQFGQDG-PISVHCSAGVGRTGVFITLSIV
                               .  . ||| ||.||.||...|||    .. || .|   | .|||   |. .||||||||||| |..  |
...............................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisidsv

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
. . .   .||.|. |  .| .|| ||||...| | | | || |
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 1416-1656 1.7e-56 186.0 In-house 1-178 (182) alignment 
Range on Protein: 1416-1656
Range on HMM: 1-178/182.0
NKPKNRYANVIAYDHSRvilqpiegimGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTrleeksrikCDQYWPnrgtetygf
|..|||| ... |||||          ..||||||...|.. .. .|||||||..|. ||.||..|..  |||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

iqvtlldtielatfcvrtfslhkngSSEKREVRQFQFTAWPDHGVPEyPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVIDAMLERikpekTV
                         . ..|.. |.... |||||||. .  .|.|...|.     . ||..|||||||||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV
...  | |.||.|. ||.|..|| |.. |||| . ...|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1704-1938 1.3e-55 183.1 In-house 6-238 (239) alignment 
Range on Protein: 1704-1938
Range on HMM: 6-238/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|..   ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
.  ||||. || .| .|| |||| ..| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1704-1938 1.8e-55 182.7 In-house 7-239 (239) alignment 
Range on Protein: 1704-1938
Range on HMM: 7-239/239.0
CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR-QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaRY
 || |||  ||. |. .|| |. .     |||||||..  |    |||||||| .. .. |||||.|..   ..|||| | |  ..|||||||   | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

QYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY
  . |       . .||.| | ...  . . | | |..|| ||..|||.     . .  ..  ||. .    |  .|||||||||| |. .  .| . . 
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
.  ||||. || .| .|| |||| ..| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0036282 (Phosphotyrosine protein) phosphatases II 1443-1643 1e-53 176.9 In-house 1-164 (174) alignment 
Range on Protein: 1443-1643
Range on HMM: 1-164/174.0
GSDYINANYVDGYRCQNAYIATQGPLPetfgdFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgtetygfiqvtlldtielatfcvrtfslhkNGSS
|||||||...|.... . .||.||||.     ||.|..|... |.||.....|. . || .|||                                . ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EKREVRQFQFTAWPDHGVPEYPTpFLAFLRRVKTCNPP-DAGPIVVHCSAGVGRTGCFIVIDAMLERIKpEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
..|.. |.... |||||||. .. .| |...|...    . ||..|||||||||||...... || ... |..||.. .|  .|.|| .||||..|| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HE
..
yy
0036282 (Phosphotyrosine protein) phosphatases II 1732-1934 1.5e-52 173.1 In-house 1-164 (174) alignment 
Range on Protein: 1732-1934
Range on HMM: 1-164/174.0
GSDYINASFIDGYRQQKAYIATQGPLAettedFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAersaryqyfvvdpmaeynmpqyilrefkvtdARDG
||||||||..|...  . .||.|||||     ||.||.|...|.||||....|.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

QSRTVRQFQFTDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERMRyEGVVDIFQTVKMLRTQRPAMVQTEDEYQF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||||... . ..| ... |..||....|..||.||| ||||.. |.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYQ
.|.
lyy
0041856 (Phosphotyrosine protein) phosphatases II 1705-1940 2.1e-52 172.7 In-house 1-171 (182) alignment 
Range on Protein: 1705-1940
Range on HMM: 1-171/182.0
NKFKNRLVNIMPYESTRvclqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTklremgrekCHQYWPaersaryqy
|. ||| ..|.||. .|          ..|||||....|.. .. .||||||| .|..||.|||.|.. |..|.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

fvvdpmaeynmpqyilrefkvtdarDGQSRTVRQFQFTDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||||... .      |.. |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

vVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 |.....||..| .|| ||.|.. |.|...|.||.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
0043147 (Phosphotyrosine protein) phosphatases II 1443-1643 7.2e-49 161.1 In-house 4-155 (172) alignment 
Range on Protein: 1443-1643
Range on HMM: 4-155/172.0
GSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLeeksrikcdqywpnrgtetygfiqvtlldtielatfcvrtfslHKNGSS
|||||||.|.|.|.. . .|||||||..|. |||||..|.   .||..|.|                                            .... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

EKREVRQFQFTAWPDHGVPeYPTPFLAFLRRVKT-CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLerikpeKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
..|.. |.... |||||||  .  .| ||. ... ..  . ||..|||||||||||...... ||      . ....  | |.|..|...||...|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

HE
..
yy
0049772 (Phosphotyrosine protein) phosphatases II 1679-1941 2.7e-48 160.7 In-house 20-281 (314) alignment 
Range on Protein: 1679-1941
Range on HMM: 20-281/314.0
GMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEsTRVCLqPIRGVEGSDYINASFIDGYrqqKAYIATQGPLAETTEDF----------WRML
...|...|.  |      .  |.|..|. |||  .|.|.. .||.| |  .|.||||||||..||.   ...||||||| .| .||          ||| 
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WENNSTIVVM---------------------LTKLREMGrekchQYWPAERSARYQyfvvdpmaeynmpqyilrefKVTDARDGQSRTVRQFQFTDWP
  ...|. ..||                     |..| . |      ...|.. . ..                    .... ..  .|.. ..  ...|
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvp

EQGVPkSGEGFIDFIGQVHKTkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERMryeGVvDIFQTVKMLRTQRP-----AMVQTEDEYQFCYQAALEYL
  ..| . | | .|.  ...      ..||. |||.||.||||.|... ... ..   || .. ......| .||      .... ..|.|...| ||||
Dgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

G
 
k
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1402-1647 8.2e-48 157.5 In-house 42-281 (290) alignment 
Range on Protein: 1402-1647
Range on HMM: 42-281/290.0
PGQQFtwEHSNLEVNK--PKNRYANVIAYDHSRVILQpiEGIMGsDYINANYVDGYRcqNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI
|.|..  | . .. |    |||| .|.  | .||||.  .|  | ||. ||||.| .    .| |||.| .|  |.|||| ... |.|||.  | |. . 
pvqyl..erkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

KCDQYWPNRGTETYGFIQVTLLDTIE---LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCnppdAGPIVVHCSAGVGRT
||.||.|..  |.  | ..|.| . |    |    .|.|. .  |  .  .. ..  .|||. |.     .|  || ...     .||.|||||||.|||
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrt

GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
| |. |.. |. .   | .|. . |  .|  |   || . ||  . |.||.
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_ptpA1_pd Subfamily ptpA1 1412-1608 9.7e-48 157.9 In-house 43-255 (418) alignment 
Range on Protein: 1412-1608
Range on HMM: 43-255/418.0
NLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCqNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR---
. . |  ||||.|..  .|.|| |. |.   |||||||||.||    . .|.||||||.|  ||||||||.|   |||..|  |. |||||.|||..   
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

--------GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC----NP--PDAGPIVVHCSAGVG
        | | .|   | |.. |.     . |  ..     | |.. |.|.  |||| .|..  ||  .|. .        |      ||.||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGCFIVIDAMLER
||| |     |...
rtgtfctavimmkk
0046846 (Phosphotyrosine protein) phosphatases II 1435-1647 3.7e-47 155.6 In-house 3-171 (176) alignment 
Range on Protein: 1435-1647
Range on HMM: 3-171/176.0
LQPIEGIMGSDYINANYVDGYRcqnaYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgTETYGFiqvtlldtielatfcvrtf
|...   ...||||||...|.|    .||||||||.|. ||..|..|..  ..|..| . |..|.||..|||    |..|.                   
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi...................

slhkngssekrevrQFQFTAWPDHGVPEYpTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLErikpEKTVDVYGHVTLMRSQRN-YMVQ
              |.... |||||||.. . .| .|. ....   . ||..||||||.||||...... .      || ..|.  . |.|.||  ..||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TEDQYSFIHEALLE
|..|| |..|..|.
tpeQyrflyefell
0049772 (Phosphotyrosine protein) phosphatases II 1406-1649 4.5e-47 156.6 In-house 36-280 (314) alignment 
Range on Protein: 1406-1649
Range on HMM: 36-280/314.0
FTWEHSNLEVNKPKNRYANVIAYDhSRVILqPIEGIMGSDYINANYVDGYrcqNAYIATQGPLPETFGDF----------WRMV--WEQRSATIVM----
.|.  ..|..|. |||| ... .| .|||| | ... |||||||.||||.   ...|||||||..|. ||          ||||  ..... .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTRLEEKSrikcdqywP--------NRGtetygfiqvtlldtielatfcvrtfSLHKNGSSEKREVRQFQFTAWPDHGVPeYP
                  ..| ..         .        .                           . . ...  .|.. ..  . .||...|  .
vladelsrLdaAlgKtpllildgng........neptaadlellk.........................eelydpelferlgikylripvpDgsap.ll

TPFLAFLRRVKTCnpPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKpektVDVYGHVTLMRSQRN-----YMVQTEDQYSFIHEALLEAV
  |..||. ....  .. ||..|||.||.||||.|.|.. .. . .    |..   .  .|..|       .... .|| ||.|||||..
edfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1691-1938 6e-47 154.9 In-house 19-293 (297) alignment 
Range on Protein: 1691-1938
Range on HMM: 19-293/297.0
KAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGY--RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE
.|..  | ||. .    |||  .|. ...||| |.  |.. ..||||| ..      ..  || .|||| .| .|||....|..  ..||..||.| ||.
eargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCHQYWPAERSARY--QYFVVDPMAEYN--MPQYILREFKVTDArdGQSRTVRQFQFTDWPEQGVPKSGEGFIDF-----------------IG------
||  |||     |     .||. ....     . || |...      .|| ||  ||  ||. |||   |    |                 .       
kcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

--QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
  |.   . .  .. .. |||||||||.|| .   ..|...| . . |.   ...|| ||. .||| ......|.|.|.
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0043147 (Phosphotyrosine protein) phosphatases II 1731-1935 7.9e-46 151.2 In-house 3-156 (172) alignment 
Range on Protein: 1731-1935
Range on HMM: 3-156/172.0
EGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLremgrekchqywpaersaryqyfvvdpmaeynmpqyilrefkvTDARD
|||||||||..|.|.  . .||||||| .|..||||||.|.. |..|.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GQSRTVRQFQFTDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQDGPISVHCSAGVGRTGVFITLSIVLERMryegvvDIFQTVKMLRTQRPAMVQTEDEYQ
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||||... . ..|...      .....|...|..|| .||... |.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FCYQA
|.|. 
flyyf
0046846 (Phosphotyrosine protein) phosphatases II 1724-1941 1.3e-45 150.6 In-house 3-174 (176) alignment 
Range on Protein: 1724-1941
Range on HMM: 3-174/176.0
LQPIRGVEGSDYINASFIDGYRqqkaYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYqyfvvdpmaeynmpqyilref
|...   ...|||||..|.|.|    .||||||| .|..||..||.|.. |.||.||...|.|| ||..||| .... .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvtdardgqsrtvrQFQFTDWPEQGVPKSgEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFITLSivleRMRYEGVVDIFQTVKMLRTQRP-AM
              |.....||. ||| . | ..... ....  ..   .||. ||||||.||||... .      ...|  ..........| |||  .
..............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTEDEYQFCYQAALEYLG
|||.. |.|.|...|..|.
vqtpeQyrflyefellllk
0049260 (Phosphotyrosine protein) phosphatases II 1451-1643 2e-45 149.5 In-house 1-144 (152) alignment 
Range on Protein: 1451-1643
Range on HMM: 1-144/152.0
YVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWpnrgtetygfiqvtlldtielatfcvrtfslhkngssekrevrQF
..|||. ....||||||.|.|. |||||..|.   ||||.|.|.|. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLerikpeKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
... |||||||. .  .| .|. .. ..  . ||..|||||||||||...... ||      . |...  | |.|..|...|....|. |..|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1411-1647 2.1e-45 150.1 In-house 36-275 (307) alignment 
Range on Protein: 1411-1647
Range on HMM: 36-275/307.0
SNLEVNKPKNRYANVIAYDHSRVILQpIEGImGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
  .. |  |||| .| . |..|.... ..|.  |||| |||.      . .|..|||| .|  .|| |. ...  ...|. .. | ..|||.||||    
eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

ETYGF------IQVTLLDTIELA--TFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVI
..  |      | |. | . .||    ..   .|. . ... | ....|.. |||.|||.     . .|  |.     |  |.||||||||||.|  . |
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivai

DAMLER-IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
  . .. |. .   |.   |  .||||.| .||| || ..|  |||
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1411-1647 2.9e-44 146.1 In-house 28-257 (267) alignment 
Range on Protein: 1411-1647
Range on HMM: 28-257/267.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEgimgSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsRIkcDQYWPNRGT
|  | |. .||. ... ||..||||.  |     .|||| ||.||. .||.|.||.||  | .||. .. .|. ..||..|.  .   |   ..|| .  
siaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmg

ETYGFIQVTLLDTIE--LATFCVRTFSLHKNGSSeKREVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNppDAGPIVVHCSAGVGRTGCFIVIDAMLE
..  . ..|.  ..|     . . |. |. .  |  ..|  . .  |        |  |... | . .  |     |.||.||.||||.| |.|||..||
qakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvvacsdGvGrsGtflvidsqle

RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLE
|.| | ..|..  .  .||||  .|.| ..| .||| | |
raktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1683-1939 3.9e-43 142.4 In-house 11-258 (267) alignment 
Range on Protein: 1683-1939
Range on HMM: 11-258/267.0
E---FKRLANSKAHTSRFISANlpcNKFKNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|    |.... ..  | .|. .   |. .||| . .||. ||| |.     |  .|||||...||....|.|.||.||  |  ||. .. ... ...|.|
efelikkisdtsstisqsiaek...nqernrlddnlpyddtrvilr...tke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKlreMGREKCHQYWPAE--RSARYQYFVVDPMAEYNMPQYI--LREFKVtdaRDGQSRTVRQFQFTDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqDGP
||    . .. ...|| .  .. .|| ..|.   | .  .|     |.|.   ..  .. |  . .  |  .   |    .  ..| . | . . | . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf...knesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrP

ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
. |.||.||||.| |...   |||.. |||.|||. .. .| ||...|.| ..| ....   ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049260 (Phosphotyrosine protein) phosphatases II 1740-1934 2.6e-42 139.4 In-house 1-144 (152) alignment 
Range on Protein: 1740-1934
Range on HMM: 1-144/152.0
FIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWpaersaryqyfvvdpmaeynmpqyilrefkvtdardgqsrtvrQF
|||||......||||||. .|..||||||.|.. |..||||.| |.|..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQDGPISVHCSAGVGRTGVFITLSIVLermryeGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
... ||  |||.. . .....  ..|   .  ..||. |||||||||||... . ..|        |.....|...|..|| .|.... ..|.|.
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1679-1940 2.8e-41 136.5 In-house 17-277 (307) alignment 
Range on Protein: 1679-1940
Range on HMM: 17-277/307.0
GMELEFKRLANSKAHTsrFISANLPCNKFKNRLVNIMPYESTRVCLQpIRGVeGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
 .  ||. ||. . ..       . .|  |||  ..   . .|. .. . |.  |||| | ..    . | .|..|||| .|  .|| |  ...   |.|
alvdefrvlakktpeg..vtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTKLREMGREKCHQYWPAERSARYQYFVVDP-MAEYNMPQY-------ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqf
| |. |... ||.||||.|.  .  .      ..  |.          ..   ..     ..|||....|...||..|||.   . |...  |.      
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......

GQDGPISVHCSAGVGRTGVFITLSIVLERM-RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
..  |. |||||||||.|  ...|.| ..| . .   |. . |. ||.||.  .||| .| . ..  |||.
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1393-1660 5.7e-41 135.1 In-house 29-300 (310) alignment 
Range on Protein: 1393-1660
Range on HMM: 29-300/310.0
LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR
| ..|  .|  |. .  .   . .  ||||..|.  | ||| |. |.     ||| ||||     ....| .||||  |  |||||....|. .|... .
lvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

LEEKSRIKCDQYWPNRG-TETYGFIQVTLL----DTIELATFCV----RTFSLHKN-GSSEKREVRQFQFTAWPDHGVPEYPTPFLAflRRVKTcnPPDA
  |. | ||  |||  | ||||| |.|| |    . .|.  ..|        . ..    ..  |   ..  ||| |||.     .   .|. .      
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrlla..qvrh

GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLeAVGCGNTEVPARS
|| |||||||..|... . ..  .....  . ||.   .| .. .|   .||| || .|.   . .   |.|||  . 
gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaeki
0044763 (Phosphotyrosine protein) phosphatases II 1428-1647 4.2e-40 132.6 In-house 2-169 (178) alignment 
Range on Protein: 1428-1647
Range on HMM: 2-169/178.0
YDHSRVILQPIEGIMGSDYINANYVDGYrcqnAYIATQGPlpetfGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTetygfiqvtlldtiela
.|..||.|...||. .||||||......     |.....|      |......|.   .||..|   |  ..|||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tfcvrtfslhkngssekrevRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERikpekTVDVYGHVTLMRSQ
                     |.... .||||||. .  ||.|.. .... ... ||..|||||||||.|...... |...      ....  . |.|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNyMVQTEDQYSFIHEALLE
|. .|....|. ...|  |.
Rp.ivpnpgqlrqLyefelr
subfamily_ptpA1_pd Subfamily ptpA1 1693-1900 9.8e-40 131.5 In-house 35-256 (418) alignment 
Range on Protein: 1693-1900
Range on HMM: 35-256/418.0
HTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRqQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQ
  |     .   |  |||  ||.| . ||| |. |.  |||||||| .|||    | .|.||||| .|  |||||.|||   |.|||..  |  | || .
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YWPAERSArYQYFVVDP----MAEY-----NMPQYILREFKV---TDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQF----GQDGPI
||| .     |. .       .  |     .. |   ||        . .|..| . |.|.  ||.. .|   . | ...  . . ..|      .. ||
ywpeqigg.eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

SVHCSAGVGRTGVFITLSIVLERM
 ||||||||||| | |  |.....
ivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1402-1647 1.1e-39 130.9 In-house 41-287 (305) alignment 
Range on Protein: 1402-1647
Range on HMM: 41-287/305.0
PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgimGSDYINANYVDGYR-CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
  |.        .... ||||..| . |.| | |.       |||| ||||      .. .|..|||| .|  .|| || ...   |||. .  |  ..|
mtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

CDQYWPNRGTETYGFIQVTLLDTIELA-------TFCVRTFSLHKNGsSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGV
| ||||    |   .    ... .  .          . .. |  .| ..|  ||..|.| ||| |||      | .|  ..  .     |||||||||.
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagi

GRTGCFIVIDAMLERIKPEKTVDV-YGHVTLMRSQRNYMVQTEDQYSFIHEALLE
||||  . |. .||.|  .| .      |  .| || . .|.. || |||  .|.
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0051082 (Phosphotyrosine protein) phosphatases II 1732-1936 1.3e-39 130.5 In-house 2-149 (151) alignment 
Range on Protein: 1732-1936
Range on HMM: 2-149/151.0
GSDYINASFIDGYrqqkaYIATQGPlaetTEDFWRMLWENNSTIVVMLTKLREMGreKCHQYWPAERsaryqyfvvdpmaeynmpqyilrefkvtdardg
 |||||.|...|.     .....||    ..||...|.|.. . .|.|... |.|  .|..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

qsRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryegvVDIFQTVKMLRTQRPAMVQTEDEYQF
  ..|......|||..|.| | . ...|. .. .      ..||. ||||||.||||... | ..|..      |.........| .|| .||......|
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYQAA
...| 
qlfal
0051082 (Phosphotyrosine protein) phosphatases II 1443-1646 3e-39 129.3 In-house 2-150 (151) alignment 
Range on Protein: 1443-1646
Range on HMM: 2-150/151.0
GSDYINANYVDGYrcqnaYIATQGPLPetfgDFWRMVWEQRSATIVMMTRLEEKSriKCDQYWPNRGtetygfiqvtlldtielatfcvrtfslhkngss
 |||||..||.|.     .....|||.    ||.....|.   |||... .||    .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ekREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnpPDAGPIVVHCSAGVGRTGCFIVIDAMLERikpektVDVYGHVTLMRSQRNYMVQTEDQYSFIH
  .||...... |||.|.|...  .|.||. .     .. ||..||||||.||||...... ||..      |...  .  .|..| ..||...|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EALL
 |||
fall
0044763 (Phosphotyrosine protein) phosphatases II 1716-1940 6.2e-39 128.8 In-house 1-171 (178) alignment 
Range on Protein: 1716-1940
Range on HMM: 1-171/178.0
PYESTRVCLQPIRGVEGSDYINASFIDGYrqqkAYIATQGPlaettEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSaryqyfvvdpmaeynm
|.. |||.|....|.|.|||||||.|...     |.....|     .|....|.|.. | .|.||.  |.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pqyilrefkvtdardgqsrtvRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPISVHCSAGVGRTGVFITLSIVLERmryeGVvDIFQTVKML
                      |.... .|  ||| . | | .|.  ...  .   ..||. |||||||||.|... . .....    |. .... ....
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTQRPaMVQTEDEYQFCYQAALEYL
| .|| .|.... ....|. .|..|
rerRp.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1411-1647 8.4e-38 124.6 In-house 32-267 (281) alignment 
Range on Protein: 1411-1647
Range on HMM: 32-267/281.0
SNLEVNKPKNRYANVIAYDHSRVILQP-IEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG
 |  ||. ||||.|. . | ||| |.  .     .||| |||.     .  || ||||  ||  |||||.|.. ...|||. .. |  | || .|.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCnppdAGPIVVHCSAGVGRTGCFIVIDAMLERI
     | ....          . |  |      | | . .. .  |||  |||    .|  ||....     . | |.||||||||.| .. ..  |. |
hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqsi

KPEKTV-DVYGHVTLMR-SQRNYMVQTEDQYSFIHEALLE
.   |. |.   |. .| . |   ||| .|| .| . ||.
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1416-1647 1.2e-37 124.3 In-house 48-285 (305) alignment 
Range on Protein: 1416-1647
Range on HMM: 48-285/305.0
NKPKNRYANVIAYDHSRVILqpiEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF
.. |||| .|   |. || |   ||    .|| ||||      . .| || || .|  ||| | ....  .| |.  | ||   || .|.. .  ..  |
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

I------QVTLLDTIE-----LATFCVRTFSLHKNGSS-EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKtcnpPDAGPIVVHCSAGVGRTGCFIVID
       .| .  . .      |   |.   |  .|.  ..| | .. .  ||| |||   .  | .| . .    |  ||||||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmle

AMLERIKPEKTVDVYGH-VTLMRSQRNYMVQTEDQYSFIHEALLE
 .|...   . ..   . .  .| |||  .||..|| |.|. .|.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1412-1648 1.8e-37 123.8 In-house 31-269 (285) alignment 
Range on Protein: 1412-1648
Range on HMM: 31-269/285.0
NLEVNKPKNRYANVIAYDHSRVILQPIEgimgSDYINANYVD-GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT
  | |   ||||.| . . .||.|.  .     ||| |...    . |..||.||||||||. |||.|..... | ..|.  | |    ||  |.|..  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

ET--YGFIQVTLLDTIELATFC----VRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDA
|   .|  ..|| .  | |         |    .. |||   . . |   |||.  ||   |.. . . ||  || .  ||.||||||||||  |. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidy

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
   ||  .  ...   |  ||. |   ||.  |. |..  |.| 
atirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1699-1939 2e-37 123.4 In-house 31-268 (281) alignment 
Range on Protein: 1699-1939
Range on HMM: 31-268/281.0
SANLPCNKFKNRLVNIMPYESTRVCLQP-IRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE
  | | |. ||| .||   . .|| |.  .   . .||| | .|     .. || ||||  ||  |||||.|..|.| .||| .. |  |||| .|.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

RSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQDGPISVHCSAGVGRTGVFITLSIVL
  .  |.  .    |    .  |   ..  . .|..| . .. . .||.  ||.| | ..  . ...       .  |  .||||||||.| .... | |
ahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtlmaveial

ERMRY-EGVVDIFQTVKMLR-TQRPAMVQTEDEYQFCYQAALEY
. ..    . || | |  || | | | ||| ..| . ..  |..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
PTPc_DSPc_SM00012 1835-1938 2e-37 123.0 In-house 1-105 (105) alignment 
Range on Protein: 1835-1938
Range on HMM: 1-105/105.0
TVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCY
||.....|.||..|||.... ..... .|.| |.. .. .|. |||||||||||.|..|.|.|.....| . |||||.||.||.||| |||||..|.|.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QAALE
.| ||
ralle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1707-1943 6.9e-36 118.4 In-house 58-286 (290) alignment 
Range on Protein: 1707-1943
Range on HMM: 58-286/290.0
FKNRLVNIMPYESTRVCLQpiRGVEGsDYINASFIDGYRqqKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARY--QY
 |||  ...  . ||| |.   | .| ||. | ...| .    .| |||.|..|. |.|||. ... . .||| .| | |. ||.||.| .         
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

F-VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqDGPISVHCSAGVGRTGVFITLSIVLERMRYE
. |.  . . .  . |.. . | |  .|..  .. ..   ||.. |..|   ..  .  . |.       ||. ||||||.|||| |... . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSF
  .|. ..|. ||  | . || . .|    .. |..  .|
keldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
PTPc_DSPc_SM00012 1547-1647 7e-36 118.0 In-house 2-105 (105) alignment 
Range on Protein: 1547-1647
Range on HMM: 2-105/105.0
VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA--GPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE
|.....|.||||||||.....| .|| ||...   .  .|.||||||||||||.|...| .|.... | |.||..  |  .|.||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_CG42327_pd Subfamily CG42327 1416-1576 2.9e-33 109.9 In-house 28-192 (319) alignment 
Range on Protein: 1416-1576
Range on HMM: 28-192/319.0
NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYR-CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNR----GT
 |.|.|..||.   ..||.|| |     . |..|.|| ||. ..| |||.| .| ..  ||||.||||.| .|| .| | |.   .| .|.| .    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFtAWPDHGVPEYPTPFLAFLRRVKT
..|| |.||| .      . . |. |..   .| ||.  . .  |.. .||  .....| | .|..
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1414-1563 3.1e-33 109.9 In-house 31-182 (297) alignment 
Range on Protein: 1414-1563
Range on HMM: 31-182/297.0
EVNKPKNRYANVIAYDHSRVILQpiEGIMGSDYINANYVDG--YRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-
.    |||| ...|.| .|| |.   .| ..|||||.||       .  || .|||| .|  |||..|.||   .|||...|.|  | ||  |||.    
nsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

-ETYGFIQVTLLDTI--ELATFCVRTFSLHKNgsSEKREVRQFQFTAWPDHGVPEY
  . | . |  | .   |  .  .  . |     ||.| ||  || .|||||||  
rlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1705-1940 3.7e-33 109.4 In-house 55-289 (305) alignment 
Range on Protein: 1705-1940
Range on HMM: 55-289/305.0
NKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGY-RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ
.. |||  ..   . . | |.       |||| | ..      .| .|..|||| .| ..|| |. .|.   .||| |  |.|. || ||||| .  . .
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

---YFVVDPMAEyNMPQYILREFKVTD----ARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHktkeqfGQDGPISVHCSAGVGRTGVFITLSIV
     ||. ..  . |     | ..|        .|. .||..|.|.||..|||      ....  .       |   || ||||||.||||  ...  .
lksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaieyi

LERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||..  .  .  . . || || ||   .|.. .| | ..  |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1736-1928 6.7e-32 105.4 In-house 78-269 (301) alignment 
Range on Protein: 1736-1928
Range on HMM: 78-269/301.0
INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQ--YFVVD-PMAEYNMP-QYILREFKVTDAR-D
| | .|.   . . .||||||| .|.|||| ||   .   .|||.. .|   |||..| | . | . .   | .     |. .  . . |...|.|.  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDE
 ..|||  .|...|...|||||     |..  | |...      || ||||||.||.  ||.  ..  ..  .  ... ...| || .|   |||.  
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1416-1648 6.8e-31 102.4 In-house 43-270 (288) alignment 
Range on Protein: 1416-1648
Range on HMM: 43-270/288.0
NKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF
|  ..|| |.   | .|| |.         ||.|| |   . ..  | .| ||  | . .|.|. |.    |||...| || . | ..|.| .  |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

IQ---VTLLDTIELAT-FCVRTFSLHKNGSsEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGVGRTGCFIVIDAMLERIKP
 .   |.  .  ..     | ..  .|.|  ||  |..  .  |.|.||||   ..| .| ..|...     |||||.|||||||| .|.|  .|| .. 
grlctvvkkkradidklvkvsllriskege.ekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrl

EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
.  . .   .. .| .|   .||| || ..|  .|| 
ddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1705-1940 1e-30 101.7 In-house 35-270 (285) alignment 
Range on Protein: 1705-1940
Range on HMM: 35-270/285.0
NKFKNRLVNIMPYESTRVCLQPirgvEGSDYINASFID-GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS----
|   ||  ..   | ||| |.        ||| ||..    ..| .||.||||| ||  |||.|..... . |.||  | | | |||  |.| .      
npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

-ARYQYFVvDPMAEYNMPQYILREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSIV
  .|.  .     |  .   ||  . |... |  |  .   . |   ||.|  |.    .|..   |.| .    .. || ||||||||||  |. .   
fgkyeitl.teckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
  |.  .  ..... |. .|. |   ||.  .. | |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1688-1940 1.3e-30 101.4 In-house 26-271 (288) alignment 
Range on Protein: 1688-1940
Range on HMM: 26-271/288.0
ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR
 .|  ..|  |  .   |  ..|  |.   . ||| |.     .   ||.|  .   . ..  | .| ||  | | .|.|| |..   .|||..| | |.
rdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk

EKCHQYWPAER--SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT-VRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGV
||  .|.| .   .||.. .  .   ...  . ...   .   . |. .  |..  . .|...|||..   .. ..  .         . || ||.||||
eksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGv

GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|||| .|   |.|| .| .  . | . .. || .|   .|||  | . ..  ||.|
Grtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1705-1940 1.7e-30 100.8 In-house 48-287 (305) alignment 
Range on Protein: 1705-1940
Range on HMM: 48-287/305.0
NKFKNRLVNIMPYESTRVCLQPirgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQY
.. |||  ..   .  || |..       .|| | ..    . | .| || || .|  ||| | ....   . || .| | | .||..|....     ..
eagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

F------VVDPMAEYNMP------QYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFIT
       .|   .  ..         . .   | .   ...| | .. . |||..||| .    .... .   .|      ||| ||||||.||||  . 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvm

LSIVLERMRYEGVVD-IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
|  .|...    ...   . .. .| ||   .||...| | .|  |.|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_egg_pd Subfamily egg 1407-1646 4.5e-30 99.4 In-house 31-267 (307) alignment 
Range on Protein: 1407-1646
Range on HMM: 31-267/307.0
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrIKCDQYWP
. ...  . |. | |   |   | ||| |.  .|    |.| ||.|.|    | .| .| || .|  ||||||....   |||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

NRGTETYGF----IQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFtAWPDHGvpEYPTPFlAFLRRVKTCnppdAGPIVVHCSAGVGRTGCFIV
.  ...  .    .... |.  . |    |   |.  |   |.| .  .|   .   .  .  .|.   ||...      . |.||..  || ...... 
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvyspl.rvlrklrnl....skpvvvqdilGvskaatlva

IDAML-ERIK-PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
|.  | . .. |     |   | ..| .|.. |..  .| |..  .|
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1446-1639 1.7e-29 97.5 In-house 77-271 (301) alignment 
Range on Protein: 1446-1639
Range on HMM: 77-271/301.0
YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGF----IQVTLLDTIELATFCVRTFSLHK-NG
 | ||...     . .|||||||..|  ||| |.      .|||...  ||   ||..| | . .|.       |...  ..|       ||. ..   |
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNppdaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYS
  . | |  .|.. |.|.|||.  .    ..  ||  .     |||||||||.||. .||  . .  ... ..|...   .  .| .|   |||. |  
kfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
0048076 (Phosphotyrosine protein) phosphatases II 1519-1646 2.6e-29 97.1 In-house 18-140 (145) alignment 
Range on Protein: 1519-1646
Range on HMM: 18-140/145.0
TLLDTIELATFCVRT-FSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLErikpeKTVDV
| ||  .|. . ..| ..|  . . ..|.. |.... |||||||. .  .|.||. .... . . ||..|||||||||||...... ||.     . |..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

YGHVTLMRSQRNYMVQTEDQYSFIHEALL
.  . |.|||| ..|....|. |..|..|
eealelvrsqrpgavpnpgqlrflyefel
subfamily_CG42327_pd Subfamily CG42327 1703-1867 1.2e-28 94.7 In-house 26-194 (319) alignment 
Range on Protein: 1703-1867
Range on HMM: 26-194/319.0
PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK-AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--
.  | |.|..|..|   ||| || |   . . |..||.. ||.. .  |||.| .| ... ||||..||..| ..| ||.| | | ..| .|.|.. .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFtDWPEQGVPKSGEGFIDFIGQVHKTK
    |  . |         .|..  . .    . .|| .  . . .|.| .|| . . .|  . .|... 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1745-1934 5.4e-28 92.5 In-house 2-198 (199) alignment 
Range on Protein: 1745-1934
Range on HMM: 2-198/199.0
RQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQ
. |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
|| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . . |.| ||
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1746-1934 7.1e-28 92.1 In-house 2-197 (198) alignment 
Range on Protein: 1746-1934
Range on HMM: 2-197/198.0
QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR--YQYFVVDPMAEYNMPQYILREFKVTDAR--DGQSRTVRQFQF
 |. ||||| || ||  |||.|.||  |  .||.   .         |||.  |.   |  . |   .    |.| .  . .|.       .| . ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVLERM--RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
| | |.  |.     ||.    .| |  ||  .| |. |||| | | ||||..| | .         |||.|.  | ||  |  .. . . |.| ||
tswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 1530-1643 8.7e-28 92.2 In-house 32-139 (144) alignment 
Range on Protein: 1530-1643
Range on HMM: 32-139/144.0
CVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLerikpEKTVDVYGHVTLMRSQRN
.| ... .    ...||. |.... |||||||.... .|.||. .... ... ||..|||||||||||...... |.     .. ....  . |.||.| 
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

YMVQTEDQYSFIHE
..|....|. |..|
gavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1543-1687 3.2e-27 90.0 In-house 87-232 (440) alignment 
Range on Protein: 1543-1687
Range on HMM: 87-232/440.0
EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN-PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
| | ..|... .|||.|||..  | | ... |. ..     ||..||||||.||||  |..|..|   |    .|..  .  ||..|  |||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL
|||.||.. ||.| .    .   ....   .|    . .. ||.  
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1417-1648 8.8e-26 85.3 In-house 44-275 (312) alignment 
Range on Protein: 1417-1648
Range on HMM: 44-275/312.0
KPKNRYANVIAYDHSRVILQPIEGImgsdYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNrgteTYGFI
|  ||| |.  .|  |  |   | .    || ||.|      . ...||||| .|   ||...    |..|.... . | .  || .|  .      ||.
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfv

QV-------TLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVIDA
..            ||.          | . .  . . ..  . ..|...|||||.|.     | .|  ||     |  |.. |||||||||| ...|..
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalies

MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
|.  ..  .  .|     |.| .|   |..  || .   ..|| 
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1704-1933 3.7e-25 83.1 In-house 51-283 (310) alignment 
Range on Protein: 1704-1933
Range on HMM: 51-283/310.0
CNKFKNRLVNIMPYESTRVCLQpIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARY
 .  |||  ...  ...|| |. |      ||| | ..     ....| .||||  |  |||||.... .  ...| |  | || ||  |||.   .  |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

QYFVVDPMAEYNMpQYILREFKVTDA-----RDGQS-----RTVRQFQFTDWPEQGVPKSGegfIDFIGQVHKTkeQfGQDGPISVHCSAGVGRTGVFIT
    |  ..|    .. . .. ||        | |        |   .. .||..|||         . |   .  |  . ||  ||||||..|..| ..
gcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvva

LSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY
| . .....    ||. . .  |. .|   .||| .| .  
lklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_egg_pd Subfamily egg 1675-1937 6.3e-25 82.5 In-house 11-267 (307) alignment 
Range on Protein: 1675-1937
Range on HMM: 11-267/307.0
EHVTGMELEFKRLANSKAHTSRFISANlPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
| | ..|  .. | .|  . |   .|.   |. | |   .   .|.|| |.  ||    |.| |  ..|      .| .| || .| .|||||.....  
eivqelerrlevleesvdeislttaas.dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevq

IVVMLTKLREMgrEKCHQYWPAERSARYQY----FVVDPMAEYNMPQYIlreFKVTDARD-GQSrtvRQFQFTDWPEQGVPKSGEGFIDFigQVHKTKEQ
 .||||  .|   |.|. |||   |   ..    . .. .  .. .. .   |.||  .  |     .. .| .  .  | .|.. .  .  .| .   .
yivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadpl...frvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrn

FGQdgPISVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL
  .  |. |..  || ........ | |  .    .    . ..|..|| .|.  |..   | | |.  |
lsk..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1708-1796 1e-24 81.9 In-house 50-152 (350) alignment 
Range on Protein: 1708-1796
Range on HMM: 50-152/350.0
KNRLVNIMPYESTRVCLQ----P----IRGVEGSDYINASFIDGY----RQQKA--YIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY
||| .||.||| .|| |.    .       ....|||||...       ...    |||||.|| .| .||.... .|. .....||.. |...|||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPA
|. 
Wqe
0048076 (Phosphotyrosine protein) phosphatases II 1825-1939 1.7e-24 81.5 In-house 36-142 (145) alignment 
Range on Protein: 1825-1939
Range on HMM: 36-142/145.0
VTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQfgqDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQ
.|. ... .|.. |.....||  ||| . | ...|. ....  ..   .||. |||||||||||...    ..  |...| |.........|.||| .|.
ltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavp

TEDEYQFCYQAALEY
... ..|.|.. ||.
npgqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1418-1512 1.8e-24 81.1 In-house 49-157 (350) alignment 
Range on Protein: 1418-1512
Range on HMM: 49-157/350.0
PKNRYANVIAYDHSRVILQ----PIEG----IMGSDYINANYVDGY----RC--QNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQ
 |||| |.. |.||||.|.    . ..    . ..|||||||.       .   .  |||||.|||.|. ||.... .     |...| . |  . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNRGTET
||.. . . 
YWqegsydd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1456-1642 1.1e-23 78.4 In-house 2-197 (199) alignment 
Range on Protein: 1456-1642
Range on HMM: 2-197/199.0
RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQ
. |  ||||| || ||. |||.||||  |  |||.   . .       |||    ||  || . ||       . ... .. | .| .     ||. ..|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTAWPDHGVPEYPTpFLAF---LRRV-KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT--VDVYGHVTLMRSQRNYMVQTEDQYSFIH
||.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
ftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1457-1642 1.6e-23 77.9 In-house 2-196 (198) alignment 
Range on Protein: 1457-1642
Range on HMM: 2-196/198.0
CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQF
 |  ||||| || ||. |||.||||  |  |||.   . .       |||    ||  || . ||       . ... .. | .| .     ||. ..||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPEYPTpFLAF---LRRV-KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT--VDVYGHVTLMRSQRNYMVQTEDQYSFIH
|.| ..  |.    |. |    | | |  .     |..|||| | | || |. .|  .   .  ||  ||..     .|  |  .. . ..| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1832-1941 1.3e-22 74.7 In-house 87-195 (440) alignment 
Range on Protein: 1832-1941
Range on HMM: 87-195/440.0
QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF
.|||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||||| |..  .|   .    .|||  .. .| .|| |||| ..| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYQAALEYLG
 ..| || | 
vheavlegll
0048179 (Phosphotyrosine protein) phosphatases II 1821-1934 1.8e-22 75.1 In-house 48-139 (144) alignment 
Range on Protein: 1821-1934
Range on HMM: 48-139/144.0
RefkvtdardgqsrtVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPISVHCSAGVGRTGVFITLSivleRMRYEGvVDIFQTVKMLRTQRP
               . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||||.....     .|...| ..........|..||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQTEDEYQFCYQ
 .|.... ..|...
gavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1708-1946 2.6e-22 73.9 In-house 46-282 (312) alignment 
Range on Protein: 1708-1946
Range on HMM: 46-282/312.0
KNRLVNIMPYESTRVCLQpirGVEgSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-------ERSA
 ||  ||  ..  |  |    | |   || | |.    . . ...||||| .|.  ||..     || ...|. . | | ||| .|          |   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

RYQYFVVD-PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPISVHCSAGVGRTGVFITLSIVLER
 |  .. .  .      .   | .||     ||   . ..|.. ||..|.| | .    ..  |.| |       |.  |||||||||| .. .  ..  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk......pviahcsagvgrtgtlaliesmiaa

MRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHY
.|.    .. ..  .|| .|   |..  .| .. .. ||.| |   |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1471-1649 5.5e-21 69.8 In-house 40-221 (255) alignment 
Range on Protein: 1471-1649
Range on HMM: 40-221/255.0
TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS--EKREVRQFQFTAWPDHGVPEYPTPFL
|   |....  ... ..||.. ..|... ||..|.|    |   . .|..  |   |   .||  .  . .   . ..|. .... |...  || .   |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

AFLRRVKtcnppDAGPIVVHCSAGVGRTGCFIVIDAM----LERIKPEKTVDV--YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
  |. |.     |. ..|||||.|.||.  |.... .    .  ..  .||..     .. .||.|.  ..|  | .|    .|. |
nilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1585-1652 1.3e-20 67.5 In-house 1-68 (69) alignment 
Range on Protein: 1585-1652
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCG
.|||||.| |||| || |   . ||| || ||..  |  ||  |  ||  | .| |||.|| ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1586-1652 2.1e-20 66.8 In-house 1-67 (69) alignment 
Range on Protein: 1586-1652
Range on HMM: 1-67/69.0
VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCG
|||||.| |||| || |   . ||| || ||..  |  ||  |  ||  |..| |||.|| ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1415-1645 1.2e-19 65.6 In-house 18-255 (290) alignment 
Range on Protein: 1415-1645
Range on HMM: 18-255/290.0
VNKPKNRYANVIAyDHSRVILQPIEGIMGSDYINANYVDgYRCQNAYIATQGPLPET-------FGDFWRMVWEQRSATIVMMTRLEEKSRI----KCDQ
 .. ..|... ..  ..||.|.     . .||| ||.|  .    . |.|| |. ..         .|| |. . ..  .||.   ||||.      | .
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPNRGTETY--GFIQVTLLDTIELATFCVRTFSLHKNgSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKtCNppdAGPIVVHCSAGVGRTGCFIV
| |..  |    . ..|   . ..   . .|.  .. .   |.  |   ..  | .  |.| .  .|. .. || ..     |..|||  |. |  ..  
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaa

IDAMLERIK-PEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL
|.     |   .. | .   .  .|.||. ..... ...|.  ..
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1415-1649 2.1e-19 64.3 In-house 46-279 (303) alignment 
Range on Protein: 1415-1649
Range on HMM: 46-279/303.0
VNKPKNRYANVIAYDHSRVILQpiegimGSDYINANYVDgYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGT-E--
 |  |||...||  |||.| |        | || |.|..   ...  | || ||. |  |||.|. ||.   ....    |  ..  |  .|.       
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

TYGFIQVTLLDTIELATFC-VRTFSLhKNGSsEKREVRQFQFTAWPDHGVPEYPTP-FLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTGCFIVIDAMLE
   .|.|  .  .||.    ..  |.  ||.  |  .   .. |||   .|   .| |.  . ....   .  |. | |    .|.||.| | ....   
eersirvgefkrvelgdgwvlkvlsv.sngd.yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

RI-KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
 . . . ..|.   .  .|  | . ||   |.|...  | | |
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
I-set Immunoglobulin I-set domain 33-124 4.5e-19 60.0 Pfam-A 1-90 (90) alignment 
Range on Protein: 33-124
Range on HMM: 1-90/90.0
PRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDEsAGAVLRIQPLrTPRDENVYECVAQNSVGEITVHAKLTV
|.| ...||.    |  ... |...|.|.|.|.| |.|....|..  .....| | . |.|.   ...||  |.|.|.||.|. . .|.|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnv.evsDeGkYtckatnsagkaeakaeLkV
fn3 Fibronectin type III domain 527-604 2e-18 59.5 Pfam-A 2-83 (85) alignment 
Range on Protein: 527-604
Range on HMM: 2-83/85.0
QPMNLRAEARSETSITLSWSPPR--QESIIKYELLFREGDHGR-EVGRTFDPTT-SYVVEDLKPNTEYAFRLAARSPQGLGA
.| ||.......||.|||||||.  .. | .||. .|| ..|. .. .| ..|| |.....|||.||| ||..|.. .| | 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1467-1641 2.2e-18 60.7 In-house 99-280 (302) alignment 
Range on Protein: 1467-1641
Range on HMM: 99-280/302.0
PLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLlDTI----ELA------TFCVRTFSLHKN--GSSEKREVRQFQFTA
|  .|   .| .. . . | .| .. . |.   || .|. ..  ..  | . |.  |.    .|.      .| . |  .. .   .  |. |  ..|.|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytv.ktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYPTPFLAFLRrvkTCNPPDaGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI
||||| |. . . |  |.    |.      ..||||||||||| .. |   ..  . .|. |.   |. .|. |   ||.|.|  ..
wpdhGapkeaytaldilk...fcesyk.knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1678-1939 4.2e-18 59.8 In-house 26-284 (302) alignment 
Range on Protein: 1678-1939
Range on HMM: 26-284/302.0
TGMELEFKRLANSKAHTSRfiSANLPCNKFKNRLVNIMPYESTRVCLQpirgVEGSDYINASFIDGYRQQKAYIATQGPLAETT---EDFWRMLWENNST
. .. |||.... |... .        |  ||.  ..  ..|..| |.     |  .|.||| ..    ..  | .| |  ...   |.|||| .... .
aevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IVVMLTKLREMGReKCHQYWP--AERSARYQYFVVDPMA-EYNMPQYilREFKVTDARDGQSRTV--RQFQFTDWPEQGVPKSGEGFIDFIGQVhkTKEQ
 ||.| .  |. .   ....|  ..    |. . |     |.   .    .. .    .| | .|      .| |... ||..    |  . .|   ...
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakk

FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
   | .. .    |.|| |.|.|| ...|..  .  . | ..|| .|.|||..|.. . | . | |.| |
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1760-1938 1.3e-17 58.7 In-house 40-219 (255) alignment 
Range on Protein: 1760-1938
Range on HMM: 40-219/255.0
TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGVPKSGEGFI
| . |....  .... ||||. . | |.|||..|.| |.  . ..  |.  .  .. . .||  ..|       . .||. .... |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPISVHCSAGVGRTGVFITLSIVLERM----RY--EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE
  .  |...|       .. ||||.|.||.  |.   .|  .|    .    . .|  . .. || .|.. ..|  .  |.    |.
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_eak_pd Subfamily eak 1422-1575 1.4e-17 58.1 In-house 57-208 (332) alignment 
Range on Protein: 1422-1575
Range on HMM: 57-208/332.0
YANVIAYDHSRVILQPIEgIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG--TETYGFIQVT
  ... ||.  | | .        ||||  ..     . || |  .  .    ||.|| ||.| .||..    |.   | |.|.|...     .|...|.
vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

LLDTIELATFCVRTFSLHKnGsSEKREVRQFQFTAWPDHGVPEYpTPFLAFLRRVK
  . .. . . .| . |.| |  |  .|  ...  | .  .| |   |||. . .|
rkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpky.edflalrkvmk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1389-1646 5.7e-17 56.1 In-house 24-282 (302) alignment 
Range on Protein: 1389-1646
Range on HMM: 24-282/302.0
DSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQpiegIMGSDYINANYVDGYRCQNAYIATQGPLPETF---GDFWRMVWEQRSA
|. .. .|...||  .  . . .    |  ||.  .| ..|. .|.|.        .|.||  |.   ...  | .| |  ..     .|||||.... .
dtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

TIVMMTRLEEKSRiKCDQYWPNR-G-TETYGFIQVTLLDtIELATFCVR--TFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD
..|.. . || ..   ....|.. |  ..|| . |     .| |   .   .  .  .| |.   .    .| |... ||.  .   .    | . . . 
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkika

AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
  ..|.    |.|| | |..  . .|... .| . .   |. .||||  .|.. .|| ... |||
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
fn3 Fibronectin type III domain 621-708 7.4e-17 54.5 Pfam-A 2-85 (85) alignment 
Range on Protein: 621-708
Range on HMM: 2-85/85.0
PPQDVKCVSVRSTAILVSWRPPPpeTHNGALVGYSVRYRPLGSEDpEPKEVNgIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES
.|..... .|.|| . .|| ||.  . .| ..||.|.||. |... |.||.. .|.|||.  |. |.  |.|...  |....| ||||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.ewkeft.vprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1708-1934 7.9e-17 56.3 In-house 22-253 (290) alignment 
Range on Protein: 1708-1934
Range on HMM: 22-253/290.0
KNRLVNIMpYESTRVCLQPIRGVEGSDYINASFIDgYRQQKAYIATQGPLAET-------TEDFWRMLWENNSTIVVMLTKLREMGRE----KCHQYWPA
..|| . .  | ||| |.       .||| |...  . .  . |.|| |....        |.|| |  . ... |||| .  |  ..     | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

ERS--ARYQYFVVDPMAEYNMPQYILREFKVTdARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLS
.     ... . |      .  . . ||  |.   |..  ||   .. .| .  |...   ... | .|.. |       |. |||  |. |  .. .. 
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaii

IVLERMR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
.    .   .| | . . .|.|| ||  ..... |. |   
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
fn3 Fibronectin type III domain 334-414 9.6e-17 54.1 Pfam-A 2-85 (85) alignment 
Range on Protein: 334-414
Range on HMM: 2-85/85.0
APGTPMVTENTATSITITWDSG--NPDPVSYYVIEYKSKSQDG-PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPS
||. . |.|.|.||.|..|.    . .|...| .||..|.. . . ... . |||.. . || |..|||..| |||  |.||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1877-1940 1.5e-16 54.5 In-house 2-65 (69) alignment 
Range on Protein: 1877-1940
Range on HMM: 2-65/69.0
SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 ||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  | || | . |  | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1878-1940 1.6e-16 54.4 In-house 2-64 (69) alignment 
Range on Protein: 1878-1940
Range on HMM: 2-64/69.0
VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
||||.| |||| ||.. . . |.. | .||||  |. .|  || ||  |.|| | ..|  | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1742-1928 1.7e-16 54.5 In-house 84-276 (302) alignment 
Range on Protein: 1742-1928
Range on HMM: 84-276/302.0
DGYRQQKAYI-ATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA--RYQYFVV-DPMAEYNMPQYI--------LREFKVTDAR
||  ...        |  .|.| .| .. . | .||| |... | . .|| .|.  .     ... . |     . .. ..           |.| .  .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIgqvhKTKEQFGQDgpISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDE
. . .||  ..|. ||. | ||  .  .| .    |  | . ..  . ||||||||||| ....   ..    . | |. . |. .|. |   ||.|. 
kkvkktvdilafsawpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_hpo-7_pd Subfamily hpo-7 1470-1649 2.4e-16 54.4 In-house 45-227 (263) alignment 
Range on Protein: 1470-1649
Range on HMM: 45-227/263.0
ETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGS--SEKREVRQFQFTAWPDHGVPEYPTPF
.|   |....  ... ..||..  .|... ||..|.|    |   . .|..  |       ..|  | .. .   . ..|...... |...  || .   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LAFLRRVKtcnppDAGPIVVHCSAGVGRTGCFIVIDA----MLERIKPEKTVDV--YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
|  |. ..     .  ..|||||.|.||.  | |..     |.  ..  .||..     .. .||.|.  ..|  | .|    .|. |
lnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_CG42327_pd Subfamily CG42327 1872-1939 1.2e-15 52.0 In-house 246-314 (319) alignment 
Range on Protein: 1872-1939
Range on HMM: 246-314/319.0
QDGPISVHCSAGVGRTGVFITLSIVLERMRYE-GVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY
. ||. |||| ||||||. |.  | ....      ||| |.|  .| .|   |.| . |.| |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1416-1560 1.5e-15 51.5 In-house 96-235 (244) alignment 
Range on Protein: 1416-1560
Range on HMM: 96-235/244.0
NKPKNRYANVIAYDHSRVILQpiEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRG-TETYG
|  ||| .  . .| .|| |   .| ||  |||| .|        || || || .|  |||.|. |.    .|..  .||.     |.|||.    | | 
nswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewye

-FIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
  | ||| |  |.       . .  .    .. .  || . ||  | 
editvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1418-1523 1.5e-15 51.4 In-house 50-168 (349) alignment 
Range on Protein: 1418-1523
Range on HMM: 50-168/349.0
PKNRYANVIAYDHSRVIL----QPIEGI----------MGSDYINANYVDGYR--CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC
 |||| ... |.||||.|    .. ..|          .  |||||||.   |   .. ||||| ||| |  ||....  ..   .. ..  .|.|  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPNRgteTYGFIQVTLLDT
|.|| .    .|  |.| | ..
diywqel...sysnitvklqns
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1835-1939 1.9e-15 51.4 In-house 216-343 (350) alignment 
Range on Protein: 1835-1939
Range on HMM: 216-343/350.0
TVRQFQFTDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE-------------RMRY-EGVVD-IFQT
 | |.|.  |.. ..    | ..  .          . ..  .  .  || |||||||||||...||  .|.             .. .   . | |...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKMLRTQRPAMVQTEDEYQFCYQAALEY
|. || ||  |||. | . |.|.|.| |
vnelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1698-1797 2.1e-15 51.0 In-house 89-181 (244) alignment 
Range on Protein: 1698-1797
Range on HMM: 89-181/244.0
ISANLPCNKFKNRLVNIMPYESTRVCLQpiRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrekCHQYWPAE
  |  | | .|||    .|..  || |   .|  |  ||||||.    .   || || |||.|. |||.|. |    ..|.|  . |       .|||  
kdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpds
subfamily_CG42327_pd Subfamily CG42327 1581-1645 3.6e-15 50.4 In-house 246-311 (319) alignment 
Range on Protein: 1581-1645
Range on HMM: 246-311/319.0
DAGPIVVHCSAGVGRTGCFIVIDAMLERIKPE-KTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL
. ||.||||| ||||||  |  |  .....   ..||.   |  .| .|   |.| .|| ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
fn3 Fibronectin type III domain 428-513 4.6e-15 48.7 Pfam-A 1-85 (85) alignment 
Range on Protein: 428-513
Range on HMM: 1-85/85.0
SAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPvgNWQKHNVDDSL-LTTVGSLLEDETYTVRVLAFTSVGDGPLS
|||.|....  ..|.. ..|..| ...| | ||.| | .. .     |.  .|. .    |.  | .. .|..|| | . .| || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 723-821 5.7e-15 48.4 Pfam-A 2-85 (85) alignment 
Range on Protein: 723-821
Range on HMM: 2-85/85.0
PPRKVEAEALNATAIRVLWRSPApgRQHGQIRGYQVHYVRMEGAEargpprikdvmlaDAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARS
.|. . ... ..| ... |  |.   ..|.| ||.|.|  ..| |             . .. | .  ......|.|.| | |...|.|.. .| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1372-1466 6.4e-15 49.1 In-house 4-95 (95) alignment 
Range on Protein: 1372-1466
Range on HMM: 4-95/95.0
PIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPiegIMGSDYINANYVDGYRCQNAYIATQG
|| .. .  |   ...|   .. .|. ||      ..     | | ||||. |.. || .||.|        |||||| .||||  .|.|||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_hpo-7_pd Subfamily hpo-7 1752-1926 9.8e-15 49.1 In-house 42-213 (263) alignment 
Range on Protein: 1752-1926
Range on HMM: 42-213/263.0
AtqgpLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD--GQSRTVRQFQFTDWPEQGV
     | .| . |....  .... ||||.   | |.||| .|.| |.  . ..  |.  .   . . .|.  ...   .   . .||...... |.|.  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PKSGEGFIDFIGQVHKTKEqfgqdgpISVHCSAGVGRTGVFITLSIVLERMR----Y--EGVVDIFQTVKMLRTQRPAMVQTE
|.  .  .  .  . . |.       . ||||.|.||.  |    .|  .|         . .|  . .. || .|.. ..| 
pelareilnilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtP
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1543-1646 2.5e-14 47.8 In-house 213-341 (350) alignment 
Range on Protein: 1543-1646
Range on HMM: 213-341/350.0
EKREVRQFQFTAWPDHGVPEYPTPFLAFLR----------RVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE-------------RI-KPEKTVDVY
.  .| |.|.  |.| ..   |  .|  |             .  .   . ||.||||||||||| .. .| .|.             .. .. || |. 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

-GHVTLMRSQRNYMVQTEDQYSFIHEALL
   |  .|.||  |||. ||. ||.||||
siivnelrkqrismvqnldqfifiYeall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1579-1648 2.5e-14 47.8 In-house 225-294 (297) alignment 
Range on Protein: 1579-1648
Range on HMM: 225-294/297.0
PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEA
 |   ...|||||||||.|  .  |..|.... ..  ||   .. .|.||  .||| .|. ....| |. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1416-1537 3e-14 47.2 In-house 34-156 (332) alignment 
Range on Protein: 1416-1537
Range on HMM: 34-156/332.0
NKPKNRYANVIAYDHSRVILQPIEGImgSDYINANYVDGYRCQNAYIATQGPLPE-TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYG
|   ||   . ..||||| | | .|    |. ||..||||  ..||| .| |. . |   ||||| |.. . |...  ..|| . |.     .|| |   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksf

FI--QVTLLDTIELATFCVRTFSLH
.       |.  || .  .| |   
lhefgaksleecelkakicrkfwpe
I-set Immunoglobulin I-set domain 136-225 1e-13 42.8 Pfam-A 2-82 (90) alignment 
Range on Protein: 136-225
Range on HMM: 2-82/90.0
NIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPsasNGRIKQLRSEtfestpIRGALQIESSEETDQGKYECVATNSAGVR
...  ..  .|.   .... | ..|.|.|...|.||  .. .   . |.|   .|       .  | |.. |. |.|||.|.|||||| .
kftqklkdvevseGesvelectveGepepsvsWakdgselks...sqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1453-1550 1.2e-13 45.2 In-house 230-323 (440) alignment 
Range on Protein: 1453-1550
Range on HMM: 230-323/440.0
DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSrikCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNgsSEKREVRQF
.||  .||.|||| ||  |  ||||.| . | .||.|. .|..|.   |  ||| |  . |.| . |    . ..    |||. |. .   |  |.|||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk..eevheirqf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1697-1755 2.5e-13 44.0 In-house 40-95 (95) alignment 
Range on Protein: 1697-1755
Range on HMM: 40-95/95.0
FISANLPCNKFKNRLVNIMPYESTRVCLQPIRgveGSDYINASFIDGYRQQKAYIATQG
.      .|  |||..||.||..|||.|   |    |||||| |.||| ....|||.||
ytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1705-1936 3.2e-13 44.0 In-house 47-275 (303) alignment 
Range on Protein: 1705-1936
Range on HMM: 47-275/303.0
NKFKNRLVNIMPYESTRVCLQpirgveGSDYINASFIDGYRQQKAyIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA-RYQ
|  |||.|...  . ..| |        | || ||...   ..|| | || ||. |. |||.|. |..   |..|    |. .   .  .| ..   ...
nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

--YFVVDPMAEYNMPQyiLREFKVTDARDGQSRTV-RQFQFTDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLER
  .  |  . . .. .     .||    .|. ..     .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .      
ersirvgefkrvelgd..gwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

MR-YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA
.   .  .|. . ....|  |   ||   .. . |   
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll
fn3 Fibronectin type III domain 932-1022 6.1e-13 41.9 Pfam-A 3-85 (85) alignment 
Range on Protein: 932-1022
Range on HMM: 3-85/85.0
PQILEAAGNaSAGTVLLRWLPPVpaERNGAIVKYTVAVREAGALGPARETElpaaaEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFS
|. | . .. .. .. |.| ||   ...| |..|.| .||.|  .. .|        |. .. .||.||||.| | ..|.|... | ||.|
Penlsvsev.tstsltlsWsppk..dgggpitgYeveyrekgggeewkeft.....vprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_eak_pd Subfamily eak 1708-1859 7.3e-13 42.6 In-house 55-203 (332) alignment 
Range on Protein: 1708-1859
Range on HMM: 55-203/332.0
KNrLVNIMPYESTRVCLQPIRgVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVV
.| .|.|.||.   | | . .  .   ||||| ..     . || |  .  .    ||.|. |..|  .|.| .  |.. ||  .|.| .    ... ..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

DPMA-EYnMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSgEGFIDF
|    |. . . ||.  ..   .  ..  |  ...  | |  .||  | |. .
dverkef.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1708-1795 2.2e-12 41.0 In-house 51-154 (349) alignment 
Range on Protein: 1708-1795
Range on HMM: 51-154/349.0
KNRLVNIMPYESTRVCL----QPIRGVEGS----------DYINASFIDG--YRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCH
|||  .|.||| .|| |    .. .... |          ||||| ..    .  .| ||||| ||  | .||....  |.  .|. |..  | . |||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1371-1454 5.3e-12 39.8 In-house 4-85 (440) alignment 
Range on Protein: 1371-1454
Range on HMM: 4-85/440.0
PPIPIADMAEHTERlkANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDG
 || .||.|.. .      |    .|.  .  | .   . ..|  || |||| |..|||||||.|. ..|.  |||||| |..|
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1411-1490 6.3e-11 36.4 In-house 32-116 (347) alignment 
Range on Protein: 1411-1490
Range on HMM: 32-116/347.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGS-----DYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM
.. | .  |||  .|   | .||.| | .  ..       |||| ..    ... || || |||.|  |||.||   . . .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1723-1848 8.4e-11 36.3 In-house 11-125 (130) alignment 
Range on Protein: 1723-1848
Range on HMM: 11-125/130.0
ClqpirgveGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrekCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILR
         | .||||||.    . . |. || |||.|. |||.|. |    ..|.|  . |       .|||       |.  ..  ... .  ..|  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlewyeediivtltdrdefknika

EF-KVTDARDGQSRTVRQFQFTDWPEQG
.. .. .      ...  || ..|| .|
snleiesdlneshqaltmfqisnwpsdg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1868-1940 8.4e-11 35.8 In-house 260-344 (349) alignment 
Range on Protein: 1868-1940
Range on HMM: 260-344/349.0
EQFGQDGPISVHCSAGVGRTGVFITLSIVLE----------RMRYEGVV--DIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL
 .  |  .. |||||| |||||..|| ..|.          .. .. .    |. .|  || || .|||   .. ..|.| |.|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
fn3 Fibronectin type III domain 838-916 9.2e-11 34.9 Pfam-A 6-84 (85) alignment 
Range on Protein: 838-916
Range on HMM: 6-84/85.0
LSVQQTPEGSLLARWEPPAgTAEDQVLGYRLQFGREDSTP-LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE
||| .. . ||  .|.||. . .... ||....  ....    .   |......| .|   |..|.||..|....| |.|
lsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1705-1789 1e-10 35.6 In-house 34-117 (332) alignment 
Range on Protein: 1705-1789
Range on HMM: 34-117/332.0
NKFKNRLVNIMPYESTRVCLQPIRGVEgsDYINASFIDGYRQQKAYIATQGPLAETTED-FWRMLWENNSTIVVMLTKLREMGREK
|   ||.  .  .. .|| | |  | .  |. |||..||| .. ||| .| |. . ||  ||||. | . ......  . |  . |
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
Ig_2 Immunoglobulin domain 142-232 3.6e-10 31.7 Pfam-A 8-78 (80) alignment 
Range on Protein: 142-232
Range on HMM: 8-78/80.0
QlKVVERTRTATMLCAASGNPDPEITWFKDflpvdpsasngrikqlrS--------EtfestpirgaLQIESSEETDQGKYECVATNSAGVRYSSPANL
.  ||.   . |. |.|.|||.|...| ||                 .        .          | | . ...|.|.|.|.|.|| |   |.. ..
p.tvvtegenvtLtCqapgnptpkvqwykd.................geelsqsqna..........lfipnvsaedsGtYtCrasnsegskqsnsvev
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1411-1542 4.1e-10 32.8 In-house 22-119 (169) alignment 
Range on Protein: 1411-1542
Range on HMM: 22-119/169.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAnyvdgyrcqnayiatqgplpetfgdfwRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRgt
..| .|. ||| |  .|  | || || .   .|||||||                           ||.||  .. ||..   ..|     ...||..  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek..

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSS
| | .    .|      .. |||  .|.| | 
edyqlhpavilgewytdslyvrtdkvhantsg
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1411-1542 5e-10 32.5 In-house 21-118 (169) alignment 
Range on Protein: 1411-1542
Range on HMM: 21-118/169.0
SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINAnyvdgyrcqnayiatqgplpetfgdfwRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRgt
..| .|. ||| |  .|  | || || .   .|||||||                           ||.||  .. ||..   ..|     ...||..  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek..

ETYGFIQVTLLDTIELATFCVRTFSLHKNGSS
| | .    .|      .. |||  .| | |.
edyqlhpavilGewytdslyvrtdkvhpntsg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1742-1821 5.8e-10 33.1 In-house 230-307 (440) alignment 
Range on Protein: 1742-1821
Range on HMM: 230-307/440.0
DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREmgrEKCHQYWPAE-RSARYQYFVVDPMAEYNMPQYILR
.|| ...|.|||| ||  |  ||||.. . . . ..|| .| .     |  ||| . ||  .  | |      || .  .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvr
I-set Immunoglobulin I-set domain 245-328 8.2e-10 30.4 Pfam-A 1-90 (90) alignment 
Range on Protein: 245-328
Range on HMM: 1-90/90.0
PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNV----LELTDV--KDSANYTCVAMSSLGVIEAVAQITV
|.|.. . . |.. | .|...| . |.| | |.|... ..|...... |  .     |....|  .|. .|||.|  |.|  || |...|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_eak_pd Subfamily eak 1570-1649 1.9e-09 31.3 In-house 226-305 (332) alignment 
Range on Protein: 1570-1649
Range on HMM: 226-305/332.0
FLRRVKtCNPPDAGPIVvHCSAGVGRTGCFIVIDAMLERIKPEKTvDVY---GHVTLMRSQRNYMVQTEDQYSFIHEALLEAV
.|.. .   ||   ||.  .. |  |.| |.||| ... |   |. ..|     .  ..|.|.. | .. |.|||.|..|. .
tlkkyi.htppsfapii.qsarGsaraGvfvvidllirlidnkkk.nlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1699-1744 1.9e-09 31.4 In-house 41-86 (440) alignment 
Range on Protein: 1699-1744
Range on HMM: 41-86/440.0
SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGY
 |.|| || |||  ||. |. .|| |. ..||  |||||||.|.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
Ig_2 Immunoglobulin domain 47-115 2e-09 29.4 Pfam-A 14-70 (80) alignment 
Range on Protein: 47-115
Range on HMM: 14-70/80.0
GGVASFVCQATGDPKPRVTWNKKGKKVNSQRFEtiefdesagavlRIQPLRTPRDENVYECVAQNSVGE
|    . |||.|.|.|.|.| |.|....... .             ..|. .. |  .|.|.|.|| | 
genvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegs
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1695-1779 4.1e-09 30.4 In-house 27-116 (347) alignment 
Range on Protein: 1695-1779
Range on HMM: 27-116/347.0
SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-----SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVML
|.| |..   .  |||  .    ..||| | | .   .       ||||| |     .| || || || .|  |||.|.   . | || .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1428-1560 4.8e-09 30.6 In-house 5-126 (130) alignment 
Range on Protein: 1428-1560
Range on HMM: 5-126/130.0
YDHSRVIlqpiegimGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKsrikcDQYWPNRGT-ETY-GFIQVTLLDTIE
.. ||.         | .||||..|      . |. || || .|  |||.|. |.    .|..  .||.     |.|||.    | |   | ||| |  |
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrde

LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
        .  ...    .. .  || . ||  | 
fknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1698-1798 5.5e-09 29.2 In-house 20-88 (169) alignment 
Range on Protein: 1698-1798
Range on HMM: 20-88/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWENNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt.....ddknnfwpek

R
 
e
subfamily_PTPDC1_pd Subfamily PTPDC1 1864-1934 6.2e-09 30.5 In-house 105-170 (182) alignment 
Range on Protein: 1864-1934
Range on HMM: 105-170/182.0
HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVlermrYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
 |  ..  |.| ..||| || ||||| |.  .|     |   ..  ...|..| .||  .|| .  ... .
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1698-1797 7.2e-09 28.7 In-house 19-86 (169) alignment 
Range on Protein: 1698-1797
Range on HMM: 19-86/169.0
ISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINAsfidgyrqqkayiatqgplaettedfwRMLWENNSTIVVMLTKLremgrEKCHQYWPAE
. |.| ||. |||    .    ||| || .    |||||||                           ||.|| |....|.|        .   ..||  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt.....ddknnfwpek
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1545-1647 8.5e-09 29.2 In-house 218-342 (349) alignment 
Range on Protein: 1545-1647
Range on HMM: 218-342/349.0
REVRQFQFTAWPDHGVPEYPTPFLAFLRrVKT-----------CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE----------RIK-PEKTVD-VYGHV
 |. |.|.  |.| ..   |  .|  |  ||             .  .  ...|||||| |||| .. .| .|.          .|| . .. | ..  |
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiiv

TLMRSQRNYMVQTEDQYSFIHEALLE
  .| ||  |||   |. .|.||||.
nelrkqrismvqnlaqfiaiyealLk
0038934 (Phosphotyrosine protein) phosphatases II 1553-1641 2e-08 29.6 In-house 85-169 (194) alignment 
Range on Protein: 1553-1641
Range on HMM: 85-169/194.0
TAWPDHGVPEYPTPFLAFLRRVKTCNPPD-AGPIVVHCSAGVGRTGCFIVIDAML-ERIkpeKTVDVYGHvtlMRSQRNYMVQTEDQYSFI
  .||.|..      | ||. |.. .  |  | ..||| ||.||||....   .   ..   .  . ...   .|. |. .... |... .
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm...saeeAial...frekRpgaipnqdyleal
subfamily_PTPDC1_pd Subfamily PTPDC1 1544-1643 7.5e-08 27.0 In-house 80-170 (182) alignment 
Range on Protein: 1544-1643
Range on HMM: 80-170/182.0
KREVRQFQFtAWPDHGVPEYpTPFLAFLRRVKTCnpPDAGPIVVHCSAGVGRTGCFIVIDAML-ERIKPEKTvdvyghVTLMRSQRNYMVQTEDQYSFIH
....  ..| .|.|.||.   .  |   . |. .   . | . ||| || ||||  |    .  .|...||.      ..|.||.|   .|| .|  ...
eqgiyvynf.gwkDygvasl.eriLdivkvvafa..lqegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvk

E
|
e
Ig_2 Immunoglobulin domain 255-318 9.4e-08 24.0 Pfam-A 10-70 (80) alignment 
Range on Protein: 255-318
Range on HMM: 10-70/80.0
EIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTpeddmpVGRN--VLELTDVKDSANYTCVAMS-SLG
..  | ||..|| | | | | |.| .. | |.       ..|   . .. ..|| .|||.|   ...
vvtegenvtLtCqapgnptpkvqwykdgeels......qsqnalfipnvsaedsGtYtCrasnsegs
0038934 (Phosphotyrosine protein) phosphatases II 1844-1931 1.1e-07 27.2 In-house 85-168 (194) alignment 
Range on Protein: 1844-1931
Range on HMM: 85-168/194.0
W--PEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPISVHCSAGVGRTGVFITLSIVL-ERMryegvvDIFQTVKMLRTQRPAMVQTEDEYQF
.  |..|.. | |   .|.  |..  ..  ..| . ||| ||.||||...   ..   .|      .  . ....|  || .... | .. 
lpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdylea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1401-1455 1.2e-07 25.6 In-house 24-77 (244) alignment 
Range on Protein: 1401-1455
Range on HMM: 24-77/244.0
DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEgIMGSDYINANYVDGY
|  ..|    . | .|  |||| |.. .|..||||   .   |||||||||..| 
dhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
Ig_3 Immunoglobulin domain 42-111 1.7e-07 23.4 Pfam-A 11-75 (75) alignment 
Range on Protein: 42-111
Range on HMM: 11-75/75.0
QIGVSGGvASFVCQATGDP-KPRVTWNkkgkKVNSQRFETIEFDESAGAVLRIQPLRtPRDENVYECVAQN
 . ..|.  .. |.|.| | .|...|     . ... ... |   | ...| | .   . |  .|.|||.|
tvtsggn.vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvt.sedsGtYtCvasN
Ig_3 Immunoglobulin domain 148-220 4.2e-07 22.1 Pfam-A 9-75 (75) alignment 
Range on Protein: 148-220
Range on HMM: 9-75/75.0
RTRT-----ATMLCAASGNP-DPEITWFkdflpvdpsasnGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATN
.. .      |  | | |.|  | |.|                 . .. .  | .. . | |.|  . | | |.|||.|
sptvtsggnvtLtCsaeggpppptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvasN
ig Immunoglobulin domain 259-313 8.4e-07 20.2 Pfam-A 1-64 (64) alignment 
Range on Protein: 259-313
Range on HMM: 1-64/64.0
GGNVNITCVA-VGSPMPYVKWMQGAEDLTPEDDMPVGRNV------LELTDVK--DSANYTCVA
|..|..|| .  |.|.. | | ..   |....   | .|       |....|.  || .||||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
Ig_3 Immunoglobulin domain 254-314 8.8e-07 21.1 Pfam-A 10-74 (75) alignment 
Range on Protein: 254-314
Range on HMM: 10-74/75.0
HEIMPGGNVNITCVAVGSP-MPYVKWM-QGAEDLTPEDDMPVGRNVLELT--DVKDSANYTCVAM
  .  ||||..|| |.|.|  | . |. ..   | . ..   . ..| ..  . .|| .||||| 
ptvtsggnvtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas
fn3 Fibronectin type III domain 1036-1099 2e-06 21.1 Pfam-A 2-73 (85) alignment 
Range on Protein: 1036-1099
Range on HMM: 2-73/85.0
SPKNFKVKMIMKTSVLLSWEFP-DNYNSPTPYKIQYN-------GLTLDVDGRTTKKLITHLKPHTFYNFVL
.|.|..|. .  ||. |||. | |.    | |...|          . .|.. ||   .|.|||.| |.| .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV
subfamily_PRL_pd Subfamily PRL 1863-1910 3.1e-06 21.3 In-house 80-127 (151) alignment 
Range on Protein: 1863-1910
Range on HMM: 80-127/151.0
VHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQ
. |.| .   .  ..||| ||.||. |...|... . |.||  |.. .
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefir
ig Immunoglobulin domain 47-109 6.1e-06 17.5 Pfam-A 1-64 (64) alignment 
Range on Protein: 47-109
Range on HMM: 1-64/64.0
GGVASFVCQA-TGDPKPRVTWNKKGKKVNSqrFETIEFDESAGA---VLRIQPLRTPrDENVYECVA
|. . ..| . .|.| . |.| |.||  ..  .... ..|  .    || |...    |. .|.||.
GssvtLtCsvssgppstdvsWykegkglee..sqktgvvenrvsaqevLtinnvtke.dsGtYtCvv
subfamily_CDC14_pd Subfamily CDC14 1873-1928 7.2e-06 20.1 In-house 263-313 (328) alignment 
Range on Protein: 1873-1928
Range on HMM: 263-313/328.0
DGPISVHCSAGVGRTGVFITLSIVlERMRyegvVDIFQTVKMLRTQRPAMVQTEDE
.| |.||| ||.|||| .|.  .. .. |    .   ...  ||  || .| .  .
eGaiavhCkaGLGrtGtLiacylm.khyr....ftaaeaiawlricrPGsvigpqq
PTPc_motif_SM00404 1831-1924 7.9e-06 20.8 In-house 44-126 (140) alignment 
Range on Protein: 1831-1924
Range on HMM: 44-126/140.0
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPISVHCSAGVGRTGVFItlsiVLERMRYEGvVDIFQTVKMLRTQRPAMVQ
 ..... | .  |  .. . |  .  .||| ..        . | . ||| ||| |.. .|    . . |||.. ... . ..... .||.. .
nsgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrq.lslaeayefvkerRpiisp