Gene PTPRG in Homo sapiens

Synonym: HPTPG, PTPG, R-PTP-GAMMA, RPTPG, PTPRG

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP099_AA protein Get Run
HsapP099_AA_830-1121 phosphatase_domain Get Run
HsapP099_AA_1132-1412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRG_pd Subfamily PTPRG 828-1137 2.4e-158 522.9 In-house 1-304 (563) alignment
Range on Protein: 828-1137
Range on HMM: 1-304/563.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHsDYINANYVDGYNKAKAYIATQGP
.|||.|.||. .|......||||.||..|..|......||||..||||.||||.||.|||.|||||.|||||..|. |||||||.|||.|.||.||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgnpkgRQNERVVIQYHYTQWP
||.||.||||||||||. ||||||||||.||||||.|||...||.||.. |||......|.||||...|.|.|.||...     ...|..|.|||||.||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq.....cdteklvrqyhytkWP

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
|.||||..||||.||..||||.. |.||..|||||||||||||||.|..|.||.....|||.|||||||.|||.||||||||||.||||||||..||||.
dhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel

SSNQLHSYVN
...|...  |
laeqveelkn

subfamily_PTPRD_pd Subfamily PTPRD 826-1159 1e-135 448.6 In-house 3-321 (564) alignment
Range on Protein: 826-1159
Range on HMM: 3-321/564.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtadMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQ
..|||... .|. .| .|..  |.|.......     . | |..|.|.||.|||| ||.|||||||.|....|.  . ||||||...|||.| |||||||
kpipvaelkehvaklkansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQ
|||..|.||||||.||||. .|||.|.|.|||. ||..|||....|.||...|||....  | |..| |.....|           ... | | |.|.|.
gPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk...........ssesreVrqFhFts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
||| ||||.| ..|...|...|.. |..||..||||||||||||.||||.||..||.. ||.. ...|..|.|||..|||||||||||.|.|||.   .|
WPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

EVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQ
||.|..|.. .. .  .    . | ||. |. .. 
evesenlkqhlqkLaeveedtemtgleleFqrLat

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 828-1138 2.7e-116 383.1 In-house 2-298 (318) alignment
Range on Protein: 828-1138
Range on HMM: 2-298/318.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGP
|.|... .|. .| .. .  .||..|...|...  ..|. .|..| ||.||||.|||||||.||||..| |.  . ||||||||.|||.. |||||.|.|
isvedleshvrrlresGelllseeyerlsrsee..tvtslkslepvnkaknryanilaydhtrvkLqmlege..egsDyinanyidGyrrkkayiaaqaP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkgqkgnpkgrqNERVVIQYHYTQWP
|  |.||||||.||||. .|||.|...|.|..|...||| ..|..||.. |.||...  . |..|.|....|...           ..|.| |||||.||
lpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee...........esrqvrqyhytsWp

DMGVPEYALPVLTFVRRSSAAR-MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
| |||| .  .| .||..|.|   ...||..|||||||||||..|..|..|..||. ..|.|... |..|.||| .||||.||.||.|.||||.   .||
degvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

VSSNQLHSYVNS
|....|.| .. 
vdasdlrsrire

subfamily_PTPRG_pd Subfamily PTPRG 1146-1416 2.7e-114 377.4 In-house 17-292 (563) alignment
Range on Protein: 1146-1416
Range on HMM: 17-292/563.0
GKTRLEKQFK-LVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGT-DYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA
|.......|. |......|.... ..||..||.|||....|...|.|| |.||||.|.. |||||.||.||..|..||.||.||..|..|||||||..|.
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

QIIVMLPD-NQSLAEDEFVYWPSrEESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD-DYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEAL
.||||... ... .....||||. .||....|..||||....|.|.......|....|..... |....||.....|||....| .|...||.|.|..| 
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

TRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKEN
...  ||..||...|....|....|.||..|...||||.||...|.|...|. .....|||.|...|.|.....||.
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

0051299 (Phosphotyrosine protein) phosphatases II 827-1120 2.2e-106 350.7 In-house 4-286 (288) alignment
Range on Protein: 827-1120
Range on HMM: 4-286/288.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmnITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQG
.|.|....|.. .|. |...|. | |||......|  .|  ....|||..|||| .||.||||||||..|.|  . .||||||.|.||||. ...|||||
eisveellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqg

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkGRQNERVVIQYHYTQW
||..|.||||||.||||. .|||.|.|||.||.||.||||...|..||.| |||.|..... |||| . ..|... .       | ...| |...|||.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.......gdgesrtvthfhytnw

PDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
||.|||... ..|.|.|.   |. .  |||.||||||||||||.|..| .|.|.. . .|.||...|..|.||...|||.|||.|...||||..
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 823-1124 1e-104 345.4 In-house 21-303 (308) alignment
Range on Protein: 823-1124
Range on HMM: 21-303/308.0
DDMEAIPVKQFVKHIGElySNNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkdSKHSDYINANYVDGY--NKAKA
  .. ..|....|.. .   .. ....| |||.....   ... .....||||.|||| .||.||||||||       ...||||||.|||||  .. ..
vsslklsvldllkllek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprk

YIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE---NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERV
.|||||||..|.||||||.||||. .|||.|.|||.|| ||.||||.|   .|.|||.. |||.|..... |||| . ..|..            ...|.
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg...........dgesrt

VIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
| ..||| |||.|||... ..|.|...    .  . ||..||||||||||||.|..| .|.|.. . .|.|.. .|..|.||.. |||.|||.|...|||
vthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

EAILGKE
| .. |.
eylklkl

subfamily_PTPRB_pd Subfamily PTPRB 826-1125 1.3e-104 344.3 In-house 5-290 (293) alignment
Range on Protein: 826-1125
Range on HMM: 5-290/293.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAehSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQ
. | ...| .|. .. ......|||..||..    |....|  .....|. |||| |||.|||||||| .|  ||...||||||||..|||  . .||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavka..aelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgynsprefiatq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE-NSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpkgRQNERVVIQYHYT
||| .|..|||||.||... ||||.|.|||||. ||..|||.. ..  ||.| |||....    ...| ..|..             ...|| | |||.|
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.............ekeerkvrqyhft

QWPDMGVPEYALPVLTFVRRSS--AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG
 ||| |||| . ..|.|||.    . .  ...|..||||||||||||.| .| .||.|... .|...|.. ..|..||.|||||.||||||...|. .  
sWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

KET
||.
kee

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 827-1137 4.5e-104 343.0 In-house 4-300 (319) alignment
Range on Protein: 827-1137
Range on HMM: 4-300/319.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQG
 |.|... ... .| |. .... ..|....  ..|   | ......|||.|||| ||||||..||.| .|.|  .. ||||||...|||.. ...||||.
eievqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqa

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIrNTKvkKGQKGNpkgrqneRVVIQYHYTQW
||. |.||||||.||... |.||.|.||||.. |. .|||.|| ||||..||||.. .  . | .|.... |.|  ...          | | ...||.|
PlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkk..ssevet.......RevkhfqyteW

PDMGVPEYALPVLTFVRRSSA-ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|| .|||.|. .| ...|     . .. ||. ||||||||||||.||.| ||...|  ....|  . ...||||| .||..|||.||..|||||.   .|
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

EVSSNQLHSYVN
|.  ..|.  . 
eievqdlrdrlk

0040438 (Phosphotyrosine protein) phosphatases II 830-1144 2.6e-102 337.6 In-house 2-300 (317) alignment
Range on Protein: 830-1144
Range on HMM: 2-300/317.0
VKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLK
|.......  |. .. ....| ||...... |   | .....||||.|||| .|| |||||||| ||.|    .||||||.||||.|. ...|||||||.
vldlllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlp

STFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDM
.|.||||||.|||....|||.|.|.|.||.||.||||.... .||...|||.|.. .| .|.|.. . ..           | ...| | ..||| |||.
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...........gdsesrtvthfhytgWpdh

GVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS
|||..  ..| |...  .|. .. ||||||||||||||||.|... ||.|.. . .|.|   .|..| ||.. |||.|||.|..||||| .. |.| .. 
gvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa

NQLHSYVNSILIPGV
..|....  .||| .
selklkllkllipla

0046845 (Phosphotyrosine protein) phosphatases II 847-1125 1.7e-100 331.3 In-house 1-279 (284) alignment
Range on Protein: 847-1125
Range on HMM: 1-279/284.0
GFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWE
|. |.|||....| .. .. .....|||..|||| .||.||||||||..|.|. ...||||||.|||||     .. |..|||||||..|.||||||.||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

QNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLT
||. .|||.|.|||.|| ||.||||.|. . .||...|||.|.... .||||.....|...           ...| |...|||.|||.|||... ..|.
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy..........tgesrtvthfhytswpdhgvppspedlle

FVRRSSAARM--PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|.|    ..   |  ||..||||||||||||.|..| .|.|.. ..   .|.||. .|..|.||.. |||.|||.|...||||... | |
flrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 843-1133 4.5e-99 326.8 In-house 10-290 (297) alignment
Range on Protein: 843-1133
Range on HMM: 10-290/297.0
NNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
.. ..... |||.... .  ... .... |||..|||| .||.|||.||||      |. .||||||.|||||.  ...|||||||..|.||||||.|||
lflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

NTGIIVMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKI--HACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPV
|. .|||.|.|||.|| ||.||||.|  .| .||...|||.|...  .. ||.| . . .|           | ...|.| ..||| |||.||||.. ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...........gngesrtvthfhytgwpdhgvpespasl

LTFVRRSSA--ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIK---DKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLH
| |...     . .|. |||||||||||||.||.|..| ||||..      .|..| ..|..|.||.  |||.|||.|...|||| .. |.| .. ..|.
ldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv





0045450 (Phosphotyrosine protein) phosphatases II 824-1122 9.8e-99 326.2 In-house 5-306 (307) alignment
Range on Protein: 824-1122
Range on HMM: 5-306/307.0
DMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYV--------DGY
 .. |......... .|  .. .|. . ||.....| ..... .....||||.|||| .||.|||.|||| .|.|. ...||||||.||        |||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgy

NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE-EYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQN
.. ...|||||||..|.||||||.|||....|||.|.|||.||.||.||||.|..| .|||. |||.|..... ||||.. . ..          .| ..
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..........dgtge

ERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA--ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQY
.| |...||| |||.|||..  ..| |...  .  .. |. ||||||||||||||||.|... ||.|...  |   |..|  .|..| ||   ||..|||
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

IFIHDALLEAILG
.|...|||| .|.
rflyeallelllk

0047943 (Phosphotyrosine protein) phosphatases II 843-1120 1.7e-97 321.4 In-house 9-272 (273) alignment
Range on Protein: 843-1120
Range on HMM: 9-272/273.0
NNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
.. ... | ||......   ..| .....||||.|||| .||.||||||||      ....||||||.||||||. ...|||||||..|.||||||.|||
lgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NTGIIVMITNLVEKGRRKCDQYWPTEN---SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVL
|. .|||.|.|||.||.||.||||.|.   |..||...|||.|......|||| . ..|..            ...|.|...||| |||.|||..  ..|
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...........tgesrtvthfhytgwpdhgvppslesll

TFVRRSSAARMP--ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
.|..    |.    . |||.||||||||||||.|..| .|.|.. . .|.||  .|..|.|| . |||.|||.|...|||| .
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 817-1123 1.1e-95 315.7 In-house 3-292 (297) alignment
Range on Protein: 817-1123
Range on HMM: 3-292/297.0
PIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmnitAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSkHSDYINANYVDGYN
|. .   ... ||.. .  ... .  |. ... ..|||..... |     .....||||.||||..||.|||||||| |..| |  .||||||.|||||.
plrdallesipiplsvldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgyd

K-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRrKCDQYWPTENSeEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkKGQKgnpkgrqne
.  ...|||||||..|.||||||.|||.. .|||.|.|||.|| ||.||||.| . .||.. |||.... .. |||| ....|    .|.          
lltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....nges.........

RVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARM--PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIH
| | ...|| |||.|||...  .| |..    |.   |. ||||||||||||||||.|... ||.|.. . .|.||  .|..| ||.. |||..||.|..
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

DALLEAILGK
||||| .. |
dallellkrk

subfamily_PTPRA_pd Subfamily PTPRA 826-1139 1.5e-95 314.8 In-house 12-314 (330) alignment
Range on Protein: 826-1139
Range on HMM: 12-314/330.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtaDMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQ
  .||... . |    ... . | |.|. .  .  ... | | ... |||.|||..||| ||.||| | .. |..  .|||||| ..|||.. . .||.|
fplpvekleeeirirsaddnklfreefnalPag..piqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRntKVkkgqkGNPKGRQNERVVIQYHYTQ
||.. | ||||||||||..  |||.|.| |. . || ||||.| .  |||| |... ...   |||| | ..  ..     .. . ....|.| |.|.| 
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq..ql.....pdatrekksrlvrqfhfts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|||.|||  .  .| ....  . .  ..||. ||||||||||||.||.|..|...| .  |.| .|.|..|.||  .|||.||| ||. .|||  |  .|
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt

EVSSNQLHSYVNSI
|.    | ......
eldvsslekhlqkl

0043336 (Phosphotyrosine protein) phosphatases II 828-1118 3.1e-95 314.0 In-house 2-275 (278) alignment
Range on Protein: 828-1118
Range on HMM: 2-275/278.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAdmnITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSkhSDYINANYVDGYNKAKAYIATQGP
|.||...|.. ||. |........|||.....    .| .....||||.|||| .||.|||||||| .|.|  .  ||||||.||||||. ...||||||
isvkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPtENSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpKGRQNERVVIQYHYTQWP
|..|.||||||.||... .|||.|.|||.|| ||.|||| ..|..||.. |||.... .. |||| . . |           .|  ..| | .|||. ||
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...........lgdgesrtvthyhylgwp

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|.||||   ..| |...   |. .. ||||||||||||||||.|... .|.|...  .|...  .|..|.||   |||..||.|...||||
dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

DSPc_SM00195 848-1120 2.5e-93 307.6 In-house 2-262 (263) alignment
Range on Protein: 848-1120
Range on HMM: 2-262/263.0
FSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
..|.||.... | .   . .......||.|||| ||| |||.|||| . ..|  ..||||||||..|.|| |.||||||||.||.||||||.||... ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR
||.|. .|.|..|||.||| |  ..|..|.| |.|......   ...| .......            ...| | ||.|..||| |||. . .|| ..| 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........eetrkvtqyqyknWpdhgvpdstksvlellra

SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||||||||...||..|........|..   .|..|.||  .|||.|||.||..|.||.|
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 848-1120 2.5e-93 307.6 In-house 2-262 (263) alignment
Range on Protein: 848-1120
Range on HMM: 2-262/263.0
FSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
..|.||.... | .   . .......||.|||| ||| |||.|||| . ..|  ..||||||||..|.|| |.||||||||.||.||||||.||... ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR
||.|. .|.|..|||.||| |  ..|..|.| |.|......   ...| .......            ...| | ||.|..||| |||. . .|| ..| 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........eetrkvtqyqyknWpdhgvpdstksvlellra

SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||||||||...||..|........|..   .|..|.||  .|||.|||.||..|.||.|
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRK_pd Subfamily PTPRK 827-1154 5.1e-92 303.1 In-house 3-312 (314) alignment
Range on Protein: 827-1154
Range on HMM: 3-312/314.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtadmnitAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQG
|| |.  ...|  |  .. .|| |..| .           . ... ||..|||. .|||||.|||.| .. |    .||||||...|.|....|.|.|||
airvadllqsiallkraegygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgd..pssdyinaalidsykrpaafivtqg

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEeYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgNPKGRQNERVVIQYHYTQW
||..| .||||.....|.  |||.|.|||.|| || .||| . .  ||.| |.| .|...| . || |....           .| .. |.| |.....|
PlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek.........largqeeirevrqfqflgW

PDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
|| .|| .|  .|..|||  . . .| |...|||||| |||||.|.||..|. |. ...|.|    | .|...  .|.|||||.||.|..||| |  || 
pdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgeta

VSSNQLHS-YVNSILIPGVGGKTRLEKQF
.   .... |..|| .      ..|...|
ipvsefkalylesirldpqtnssqlkeef

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 826-1138 6.9e-92 302.8 In-house 2-301 (305) alignment
Range on Protein: 826-1138
Range on HMM: 2-301/305.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHsnhpENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQ
. | .... ..| |  .....|. ........    .... ..    .||.|||. .|  .|..|..|.. . .|  .||||||.|||||.. |.||..|
kiialddlaayikearvysdkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE--EYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHY
||||.| .||||.|.|  .  |||.|.||| |. || ||||.. .|  |.|...|.|||.|  . |. |...| . .            ...|.|.||. 
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede..........dkesrtvlqyql

TQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG
|.||| |||..|  .|....|   ... . | |.||||||||||||..|..| .|...|   .|.| . ||..|..| ..||| .|| |.|||| | |  
tdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

KETEVSSNQLHSYVNS
 .|..  . |.  || 
gdtsiigsnlrarvnk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 842-1127 7.8e-92 302.7 In-house 23-297 (298) alignment
Range on Protein: 842-1127
Range on HMM: 23-297/298.0
SNNQHGFSEDFEEVQRCTADMN-ITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIW
...  |....|..... . ...  . | ...||||.|||| .|.|.|.||| |.     . ..|||||| ....|.. .|.||||.||..|.||||||..
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLT
|.. | |||.|||.|... |. .|||.|..|.||.| |.|.|.. .| ..||.. . ..|           ...|| | | |.|.||| ||||.|  ||.
eedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk...........eekerevrqlhftsWpdkgvpenatsvld

FVRRSSAaRMPETG--PVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
..|.  |    ..|  ||.|.|||||||.||.|.|||.|...| ...| |.  .| .|..|  .|||||||.||..| |||.   ..|.
llrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_Ptp69D_pd Subfamily Ptp69D 828-1138 8.9e-92 302.5 In-house 4-304 (307) alignment
Range on Protein: 828-1138
Range on HMM: 4-304/307.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtaDMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGP
|....  . .     . ..|. ...|....    .. ... |.. ||. |||| .| |.|. ||||....||.  .||||||... ||.. | .|| |.|
iaiddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgnpkgrQNERVVIQYHYTQWP
. .| .||||||.||.  .|||..|| || |.||..||| |.  .||.|.|.| |.. |  |. | ... ..| . |.       ...| |.|||||.|.
veatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev......edsrkvvqyhytgWk

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
|. ||| |  .| ....       . .|..|||||||||.|... .||.|||.|   .|..  . |..| ||| |||  |||.|.. |||. .   .|..
DskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtde

SSNQLHSYVNS
. ..|.. ...
dvddledaier

Y_phosphatase Protein-tyrosine phosphatase 874-1118 2.5e-91 300.7 Pfam-A 1-235 (235) alignment
Range on Protein: 874-1118
Range on HMM: 1-235/235.0
NKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSE
||.|||| .||.||..||||     .....|||||||||.||.. |..||||||||||.||||||.|.... .|||.|.|.||||.||.||||  .|.|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNIIVTLK-STK-IHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGT
.||.| |.|| ..| ... ||.| ......| ..          ..| | |.|||.||| |||| . ..| ..|.    . ...|||.||||||||||||
tygdikvelkekekedekeytlrklelkkkkees..........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

YIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
....| .|.|......|.|| ..|..|.||. .||..|||||...|.||
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 874-1118 2.5e-91 300.7 In-house 1-235 (235) alignment
Range on Protein: 874-1118
Range on HMM: 1-235/235.0
NKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSE
||.|||| .||.||..||||     .....|||||||||.||.. |..||||||||||.||||||.|.... .|||.|.|.||||.||.||||  .|.|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNIIVTLK-STK-IHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGT
.||.| |.|| ..| ... ||.| ......| ..          ..| | |.|||.||| |||| . ..| ..|.    . ...|||.||||||||||||
tygdikvelkekekedekeytlrklelkkkkees..........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

YIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
....| .|.|......|.|| ..|..|.||. .||..|||||...|.||
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 834-1120 7.4e-91 299.2 In-house 9-279 (288) alignment
Range on Protein: 834-1120
Range on HMM: 9-279/288.0
VKHIGELYSNNQHGFSEDFEEVqrCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFE
|... .   .|. ||||... .   . . . . . .....|..|||| |||.||. ||||. |.  . . .|||||.|.||..| |.|||||||| .| .
vakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvn

DFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS-EEYGNIIVTLKSTKIHACYTVRRFSIRntkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVP
|||....|..|  |||.|.|||.|..||..|||...  ..||.. |||...|    ...|.. .               ...|. . ||.|. |||.|||
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.............kkkteleitqyqylaWpdhgvP

EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
| . |.| ..|    |   .|||..||||||||||||.|..| ...... . ...|.|.....| ||. ||||..||.||...||. |
eskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 870-1120 2.2e-88 290.7 In-house 5-242 (250) alignment
Range on Protein: 870-1120
Range on HMM: 5-242/250.0
NHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRkCDQYWPTEN
..|.||.|||| .|.|.|.||| | .      |.|||||| ...||.. ||.|||||||..|.||||||..|...| |||.|||.|...  . ||||.|.
kkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMP-ETGPVLVHCSAGVGRTG
.|.||.. |.|.|....| ||.|.. . ..|           ...||.| |.|...||| ||||.|  || ....  | .   ...||.|.|||||||.|
aekyGdvtvsllskeefadytkrklklskak...........kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..|.||..|...| . .|.|  ..| .|..|   |...|||.|.. ..|.|.
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 826-1154 4.2e-88 290.3 In-house 4-314 (315) alignment
Range on Protein: 826-1154
Range on HMM: 4-314/315.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSnhpENKHKNRYINILAYDHSRVKLrPLPGKDsKHSDYINANYVDGYNKAKAYIATQ
. ||. |.. .. .  .. . || .|.| .         .| ..   |||.|||||||.|||.|||.| ||  .| .||||.|||..||||| . |||.|
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakki...enkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEnSEEYGNIIVTLKSTKIHACYTVRRFsirntkvkkgqkgNPKGRQNERVVIQYHYTQ
||. .. .||||...|.. | |||.|||||. .||...||| .    ||.| ||.|| ...  |||| .                 ..| | |.|.||| 
gpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl.............svvfgdnirevvqlhyts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|||||||.|..|.. ..|.    .  . |...||||||||||||.| .|..|.|.. .  ..|  |.. .| .|  .||. ||| ||.|||||...  .|
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdt

EVSSNQLHSYVNSILIPGV-GGKTRLEKQF
 .. .      .|.| |    | | |..||
siaqdlylqrydsllapspdtgstllqeqf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 835-1120 1.5e-86 285.0 In-house 4-276 (281) alignment
Range on Protein: 835-1120
Range on HMM: 4-276/281.0
KHIGELYSNNQHGFSEDFEEVQRctADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPlpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFED
||. .| .|...|| |..|...   .... ||. |...||..||||.|| |||..|||. |   ...|..||||||.|.||.. |.|||||||. .....
khlkqlsqndnaGfieeyeklaa..igvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIrNTKvkKGqkgnpkgrqNERVVIQYHYTQWPDMGVPE
||.|.|||.  .|||.|. .|.|. || .||| .| . .||...|. .... .| |  |.|.. ...  .|         ..| | | .||.||| |||.
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.ere..sg.........etreveqlaytaWPdhGvPa

YALPVLTFVRRSSAARMPET-GPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
 .  .| | .    .. ..|  |...||||||||||||| .| ........ ....|   ....| .||..|||  || |.. |.|.|.
ttkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

0040439 (Phosphotyrosine protein) phosphatases II 867-1121 2.7e-86 284.4 In-house 4-247 (249) alignment
Range on Protein: 867-1121
Range on HMM: 4-247/249.0
EHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.....||||.|||| .||.|||||||| .|||    .||||||.|.|||.  ...|||||||..|.||||||.||.. ..|||.|.|||.|| ||.||||
svallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA--ARMPETGPVLVHCSAGV
...| |||.. |||.|..... |||| . . |.           . ...| | ...|| |||.|||..  ..| |...     .. |. |||||||||||
lggsleygdftvtllsvevkddytvrtleltnl...........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv

GRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
|||||.|... ||.|.. . .|...  .|..|.||.. ||..|||.|...|||| .|
gRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0045098 (Phosphotyrosine protein) phosphatases II 865-1122 6.2e-86 283.5 In-house 24-274 (278) alignment
Range on Protein: 865-1122
Range on HMM: 24-274/278.0
TAEHSNHPENKHKNRYINILAYDHSRVKlrplpgkdskhsDYINANYVDGYnKaKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQY
. .... ..|..|||| .||.|||||||            |||||.|.||| . |..|||||||.||..|||||.||... .|||.|.|||.|| ||.||
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrQNERVVIQYHYTQWPDMGVPEYA--LPVLTFVRRSSAARM------------
|| ..|..||.. |||.|.... .||.|.. ..|. |..           .| | ..||. |||.|||..    ..| ....  .|.             
wpeggsltygdftvtllseevlddytlrtllvtnltvered.......lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

-PETGPVLVHCSAGVGRTGTYIVIDSMLQQIkdKSTVNVLGFLKHIRTQRNY-LVQTEEQYIFIHDALLEAILG
 .. ||||||||||||||||..... ||...  ...|..|  .|..|.||..  ||..|||.|....||| .| 
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_PTPN6_pd Subfamily PTPN6 841-1119 8.7e-86 282.7 In-house 21-296 (306) alignment
Range on Protein: 841-1119
Range on HMM: 21-296/306.0
YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpGKDSKHSDYINANYVDG--YNKAKAYIATQGPLKSTFEDFWRM
 | .. ||.|.|||.|.  |   .. .....||||.|||| ||| .||.||.|.    .. . ||||||||...   .. |.|||||| |..| .|||||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWEQNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALP
.|..|. .|||.|. ||.|. || .|||.|. .||||.| ||  | | .| |..|..|. ..          |  ..|| |.|||...||| |||.    
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..........kkkkeerevfqyhfksWPdhgvpkdpga

VLTFVR---RSS-AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
|| |..   | .   .  |.||..||||||.|||||.|||| .|..|. |     ...  . | .|.||. |||||.|| |.. |. . 
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

0042113 (Phosphotyrosine protein) phosphatases II 867-1118 3.3e-85 280.7 In-house 2-241 (245) alignment
Range on Protein: 867-1118
Range on HMM: 2-241/245.0
EHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.....||||.|||| .||.|||.|||| | .|  . .||||||.|||||.  . .|||||||..|.||||||.||..  .|||.|...|.|| ||.||||
svallpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARM-PETGPVLVHCSAGVG
...| .||...|||.|..... |||| ... |.           |   .| ||.|||. |||.|||..   .| |...   |.  .. ||||||||||||
lgesltygdftvtllseehlddytvrtlevtnl...........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvg

RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
||||.|... ||.|..   .|..   .|..| ||   |||..||.|...||||
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 843-1137 9.9e-85 279.6 In-house 31-308 (319) alignment
Range on Protein: 843-1137
Range on HMM: 31-308/319.0
NNQHGFSEDFEEVQRCTADmNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
...  .  .|  . . ...   . ...| ..|| |||.|||||.|...|||..| |..   |||||| .|.|| . . |||.||||. | .||||||||.
ddltklevefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

NTGIIVMITnlvekgRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFV
|.  ||..|      . || |||| .  .....  | ..| .  | |.|| . . .   .|..          | . |.|.  |||.|||.|. .....|
ncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdi..........rkitqfhflGwpdvGvpdypsdlmrlv

RR--SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVN
..      .. .  ...|||||||||||.|||.| .|...|... |.|  |.. .| ||| |||   || ||. ||||  |   ..|.  .. .|..
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 861-1137 2.2e-83 275.1 In-house 11-272 (284) alignment
Range on Protein: 861-1137
Range on HMM: 11-272/284.0
DMNI-TAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITnlvekgRR
 .|  . ...| ..|| |||...|||.|...|||..| |..   |||||| .. || . . ||||||||. | .||||||||.|.  ||..|      . 
gvngtdqtfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

KCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqKGNPkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR--SSAARMPETGPVL
|| |||| .  .....  | ..| .  . |.|| . . .       .|.    .. | . |.|.  |||.|||.|. .....|..      .. .  ...
kcsqywplkivikeerfkvkvdsveeseeyvvrdielse.......dgke...kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVN
|||||||||||.|||.| .|...|... |.|  |.. .| ||| |||   || ||. ||||  |   ..|.  .. .|..
vhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle

subfamily_PTPN9_pd Subfamily PTPN9 832-1121 1.4e-81 268.8 In-house 5-291 (297) alignment
Range on Protein: 832-1121
Range on HMM: 5-291/297.0
QFVKHIGElysNNQHGFSEDFEEVQRCTadMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKST
..|... |   ....| |....|... .  .. |...|... | .|||| ..| ||..||.|  ....  ..|||||||.||||.. ||.|||||||| |
elvayvke...kgkrGlskeyaeirnep..veGtflasklranleknrytdvlcydetrvvlakvded..easdyinanfvdGykqkkafiatqGplkkt

FEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDM
..|||||.|||.. .|||.| .||.||.|| ||||  .|.|.|.|.. |.  ... .  |.|| . |.|.|            ...| |. . .. ||| 
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk...........teesrkvthfqflsWPdy

GVPEYALPVLTF---VRRSSAA----------RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
|||. |  .| .   ||.  |.            |.  |..||||||.|||||.| .|  |.......||.|   .|..|||| . .||.||| | . |.
GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

LEAIL
||  |
leyal

0037934 (Phosphotyrosine protein) phosphatases II 868-1118 1.3e-79 262.4 In-house 4-240 (243) alignment
Range on Protein: 868-1118
Range on HMM: 4-240/243.0
HSNHPENKHKNRYINILAYDHSRVKLrplpgkDSkhSDYINANYVDGYNKakaYIATQGPLKSTFED----FWRMIWEQNTGIIVMITNLVEKGRRKCDQ
....|||..|||| .||.||||||||      ..  |||||||.......   .|||||||..|.||    ||||.||.....|||.|.|||.|| ||.|
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPteNSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAA--------RMPETGP
|||  ....||...|||.|.. .. |||| ....|.. .. .          | ||.|||. |||.|||.   ..| |..   .           .. ||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

VLVHCSAGVGRTGTYIVIDSMLQQIkdksTVNVLGFLKHIRTQRNY-LVQTEEQYIFIHDALLE
||||||||||||||.|... ||...    .|...  .|..|.||..  |||..||.|...||||
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 828-1120 9.9e-79 259.2 In-house 2-283 (290) alignment
Range on Protein: 828-1120
Range on HMM: 2-283/290.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP
|||..| ... .  .....|| ..|. ..    .   |... . ..||..||. ||. ||  |. |||..|.     .|||| |..||...|.|||||||
ipvdkfgefvanghakgnegfrnqfkmldsgeseh..tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpKGrQNERVVIQYHYTQWP
...|  |||..||.... ||||.|| .|.|. || ||||......||.. ..| . ...  |. |.....|..         .. .... |.||. | |.
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkn.........sa.gakqsvtqyqitnwd

DMG-VPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
. | |....  .|.. ..    | .  ....||||..|||........  ... | .  ..|.  ||. |.|.  .|||..|| .|.. .|...
stgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_PTPN12_pd Subfamily PTPN12 843-1120 3.5e-77 254.2 In-house 5-277 (290) alignment
Range on Protein: 843-1120
Range on HMM: 5-277/290.0
NNQHGFSEDFEEVQRCTAD----MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRM
.... |...|........       ...|.....||..|||| .|| ||.|||.|.   ...  .|||||||.. | .. ..|||.||||  | .|||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWEQNTGIIVMITNLVEKGRRKCDQYWPTEN--SEEYGNIIVTLKSTKIHAcytvRRFSIRNTKVKKGqkgnpkgrQNERVVIQYHYTQWPDMGVPEYAL
|||.|. |.||. ..|| |. ||..||| |.  . |.|.. |||.. |         | ||  ||..         ...|.| |.|||.||| |||. | 
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd....ddflirtLkveaq........kesrkvyqfhYtaWPDhgvPssak

PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..| ...     .  |  |..|||||||||||| |.|| . ...|.. .   ..|   . ..|.||. ||||.||| ... |..| .
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 874-1119 2.4e-75 247.7 In-house 7-239 (239) alignment
Range on Protein: 874-1119
Range on HMM: 7-239/239.0
NKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSeE
|| |||| ||..|||||| |  |   .  |||||||.|.  |.   |||||||| .. .  |||||.|..   .|||.| |.|  ..|| ||||   | .
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k

YGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIV
| |. |||. |.. | | .| | . .            |. .|| | |||.| ||| |||.||  || . |. .   .| . | ..||||||||||...|
ycnlrvtlrktevfadyiirtfvmsqv...........gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv

IDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
||.||.| | . ||... ..| || .| ..||| |||.||| |.|||
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 873-1118 7.3e-75 246.2 In-house 7-239 (239) alignment
Range on Protein: 873-1118
Range on HMM: 7-239/239.0
ENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSe
 || |||| ||..|||||| |  |   .  |||||||.|.  |.   |||||||| .. .  |||||.|..   .|||.| |.|  ..|| ||||   | 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

EYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYI
.| |. |||. |.. | | .| | . .            |. .|| | |||.| ||| |||.||  || . |. .   .| . | ..||||||||||...
kycnlrvtlrktevfadyiirtfvmsqv...........gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

VIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||.||.| | . ||... ..| || .| ..||| |||.||| |.||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

0051299 (Phosphotyrosine protein) phosphatases II 1124-1410 8.3e-75 247.2 In-house 2-285 (288) alignment
Range on Protein: 1124-1410
Range on HMM: 2-285/288.0
ETEVSSNQLHSYVNSILipgVGGKTRLEKQFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIIT
.||.| ..|...|. .|    .|.|.|...|. ....... ... .|....|.||||.|...| .. || | .|.|. |.|||||||| ||.....||.|
dteisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEAT----QDDYVLEVRHFQCPK
|.|||.|..|||||.|..| ..|||| . . |  |. . |||. ..|.... .||||.| .      .. .... .... .    .|.....|.||....
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytn

WPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
||. ..|  ... ..... ...    ..||..||   |   .|...|| .| .|||.|. |||... |..  .|||...  |||.|.|.|.| .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 828-1149 1.1e-74 246.1 In-house 3-307 (315) alignment
Range on Protein: 828-1149
Range on HMM: 3-307/315.0
IPVKQFVKHIGElySNNQHGFSEDFEEVQRCTADMNitaEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQGP
||| ||   . .    .   |||.| ..    .  .     . ...| .|||| ||| .|..||||  .   || .|||||| |. .... |||||.|||
ipvaqfpafvnk..nrhtalfseefhdlpdPdiyrq...rvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgrqNERVVIQYHYTQ
||.. .|||||......  |||.|.. |  . || ||||    .| |.|.| |.| |..  .  ..|.. .|...             . | | |...|.
lkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse.............esrtvtqfqfte

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
||| ||.. .  .| ...   | . ... ..||||||||||||  | ||....|||....|.|. |.| .|..| |||||||.| ||.||.|| .| ..|
wPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

EVSSNQLHSYVNSILIPGVG-GKTR
 .   ..  ... .   . | |...
lilvihftdhlqdlhtsvdgsgrsk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 862-1117 2e-74 245.1 In-house 16-265 (274) alignment
Range on Protein: 862-1117
Range on HMM: 16-265/274.0
MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYVDGYN-KAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
.| . |. . . ...|||| .||  ..||| |..  .. .. |.||||||. ||. . |||.|||||| .| .||||||..... .|||.|.| |. ..|
lnfdqeeldvfgsqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

CDQYWPTEN----SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGqkgnpkgrqnervVIQYHYTQWPDMGVPEYALPVLTFVRRSSA---ARMPET
| .|.|...    ||.||.. .. .... .  |.||........ ..              |. | ||.|||. .|. | ..| .|.  .    ..  ..
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers.............vkhywytdWPdhksPddantlldlvleveesreeenakl

GPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
.||.||||||.|||| .| |.  ..|......|.||.   ..| .|  .|||.||| .|| || 
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 831-1132 2.9e-74 245.1 In-house 5-291 (439) alignment
Range on Protein: 831-1132
Range on HMM: 5-291/439.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKS
..| .|. .|  |.|  |.| ||...    | .  |    .  .. |||| .. |.||.|| |. .||    || ||||||..|| . | ||||||| | 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkke

TFEDFWRMIWEQNTGIIVMITNLVEKGRrkcdqYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkGqkgnpkgrQNERVVIQYHYTQWPDMG
| .||||...|..|  |||.|||||  .     |||...   ||.|.|          |..| | . | . . .        ..|| |.|.||. |||  
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt.t........ekertvlqfhyiawpdkn

VPEYALPVLTFVRR-SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS
||  |  || |.|   ||    |.|||.|||||||||||| | .|  |.|.| .  |.. | .| .| ||. .||.  ||.||..|.|| |   .. |. 
vpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavti

NQL
...
def

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 842-1157 3e-74 245.0 In-house 12-314 (515) alignment
Range on Protein: 842-1157
Range on HMM: 12-314/515.0
SNNQHG--FSEDFEEVQRCTADMNI-TAEHSnhpeNKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRM
. |.|   |||.| ..       .  . |      | .|||| ||| || .||||  .  .|. ||||.|| |. ...  |||||.|||.|.. .||||.
nknrhttlfseefhdlpgpniypqtvaqeei....nfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrl

IWEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTvrrfsIRNTKVKKGQkgnpkgrqNERVVIQYHYTQWPDMGVPEYAL
....|.  |.|.|.| |  . || .|||    .| ..|.| | | |..  .  .     .|. .| ||.        . | | |.|.|.||| |||. . 
vlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi.....krkltvlkgd........dsrtvtqfhfteWPdkGvpkhts

PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYV
 .| ...   | .   | |...|||||||||| .| |||.. ..|.  .|.|. |.. || .| |||||.||| ||..|.|| .| ..| .   ..  ..
sllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhl

NSILIPGVG-GKTRLEKQFKLV
. .   | | |.... |.|. .
qdlhssgdgrgrskmtkefqtl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 828-1127 4.8e-74 243.9 In-house 2-285 (287) alignment
Range on Protein: 828-1127
Range on HMM: 2-285/287.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNItAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGP
|||..| . . .   ... ||.. |  ... | . .    |.  ..||.|||. .|| .|  || |.       .| ||||| ..|||...||.|....|
ipvekfgefvakghakgnegfknqftvleqvtqrede.vthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqKGnpkgrQNERVVIQYHYTQWP
. .|  .||..|...|  .|||.... |. ...| ||||.|.|  .|.  ..| . ...| |..|.. ..|..     |      .... | ||..|.|.
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.....ka.....gdkqqvkqyqitnWd

DMG-VPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. | |.|..  .| . ..  . | .  ....||||..|||..... ..  ... |   ...|.  ||. | |.   ||| |||.|| |..|| .   || 
stgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

V
.
s

subfamily_PTPN3_pd Subfamily PTPN3 851-1119 2e-73 241.7 In-house 20-274 (280) alignment
Range on Protein: 851-1119
Range on HMM: 20-274/280.0
DFEEVQRCTADMNITAehSNHPENKHKNRYINILAYDHSRVKLRplpgkDSKHsDYINANYVD----GYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
 ||.. |   ...|.|  .. ||| .|||| .||.||. ||||.     .|.  ||||||||.    . .  . ||||||||..| .|||.|.|||.. .
qfeqlyrkkpglaisa..arkpenlsknryrdilpydatrvklk.....eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVMITNLVEKGRRKCDQYWPT-ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRS
|||.|.|||.|| || ||||. |.. |||.. |...... .  | .| . ..... |           .|| ..|  |..||| |||. .  .|.||.| 
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk...........eerkilqlqylaWpdhgvPddsadflefverv

SAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
 ..|  .. ||.||||||.|||| .|...  |. |  .  |..|  ....| ||  ||||..|| |. .|.|..
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 822-1131 2.6e-72 238.5 In-house 4-295 (297) alignment
Range on Protein: 822-1131
Range on HMM: 4-295/297.0
PDDMEAIPVKQFVKHIgelySNNQHgfSEDFEEVQRCTADMNITAEHSNHPE-NKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKakA
| . . ||. .|   .     .|.|  .. |.|  .|.   ||...   .   | .|.|| ||| || |||||. .   |.  |||.|| .| |...   
pkerrpiplsdfatlv....qknrh..tdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaiv..nddpdsDyvnasfvkgnkh..r

YIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRrKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRntkvkkgqKGNPKgrqNERVVIQ
.|.|| | |.| .|||.|...... .|||.... |. . || .||. . . ..|.. |.|.|..    .  | ....        ||..|   ..||| |
littqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt........kgkak...arrvvkq

YHYTQWPDMGVPE-----YALPVLTFVRRSSAaRMPETgPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDA
|....|||  |..     . | ... || .      |. |.||||.||||||| .. |||.. ..|.. .|...|..|..| .| |||||.||| |.. |
yqfveWPdkaverkdsassllklisevrkdfs.qnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyva

LLEAILGKETEVSSNQ
.|||.| ..|.. .. 
vleallsedtriqasy

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 872-1118 3e-72 237.7 In-house 1-237 (237) alignment
Range on Protein: 872-1118
Range on HMM: 1-237/237.0
PENKHKNRYINILAYDHSRVKLRPlPGKDskhSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP-TEN
.||| |||| || ||||||| |.  .| .   ||||||.|..|..   | |||.||||.|. .|||.|.|...  .|||.| |.|. . || .||| |..
senkiknrygnivaydhsrvvlkg.agsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRR--SSAARMPETGPVLVHCSAGVGRT
 . || . |.||  .  . |||| . . .   .|          . |.. ||..| ||| |||...  .| | ..    .  ..|.|| ..|||||||||
paaygvltvslkkkeefsdytvrslllskrltlk..........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrt

GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
| ..|||.||.| |.|  |..  ... |  .| |..||..||.|||...||
giflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0050432 (Phosphotyrosine protein) phosphatases II 1145-1414 2.3e-71 236.0 In-house 39-302 (308) alignment
Range on Protein: 1145-1414
Range on HMM: 39-302/308.0
GGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGmKGTDYINASYIMGY--YRSNEFIITQHPLPHTTKDFWRMIWDHN
 ....||..|. ....   . |...|....||.||| ....| .. || |    . .|.|||||||..||  .....||.||.|||.|..|||||.|..|
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

AQIIVMLPDNQSLA-EDEFVYWPSR--EESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIK
 ..|||| . .    |  . |||.   ..|.... |||||.| .      .. ...  ..|. ..|.....|.||... ||. ..|  ... ..... ..
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

EEAltRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.    ..||..||   |   .| ..|| .| .||| |. ||||.. |..  .|||.... |||.|.|.|.| ....|
ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 827-1139 4.9e-71 234.5 In-house 4-307 (325) alignment
Range on Protein: 827-1139
Range on HMM: 4-307/325.0
AIPVKQFVKHIGELYSNNQHGFSEDFeevQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQG
.| | ..|.|. .  ...| ||. .|   .   .|  |. . . .|||| |||. |..|.|.||| |  .  ||. .||||||.|.  . | . ..|.| 
siavvnlvehvekkkaqdqdgfahef...gllpsddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqa

PLKSTFEDFWRMI--WEqntGIIVMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkVKKGqkgnpkgrqNERVVIQYH
|| .| .|.||..  |.     .|...| ...|  .| .||| |  .| ..| . | |.. .  . |  |.. ...  ||||         . | | |..
PltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq..vkkG.........etrsvkqfq

YTQWPDMGVPEYALPVLTF---VRRSS---AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
.  |.||||...   ....   |   |    |    ..|.||||||||||||..| . |.|... ..| |...||.|..| .|  .|.| .|||.|..||
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

LEAILGKETEVSSNQLHSYVNSI
 ||..  .|.|  . ... ..|.
veaymsgntdvpvssfeaklssl

0047943 (Phosphotyrosine protein) phosphatases II 1142-1409 6.1e-70 231.1 In-house 6-270 (273) alignment
Range on Protein: 1142-1409
Range on HMM: 6-270/273.0
PGVGGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDH
 .  |.|.|...|.|....   ....  |....||.|||.....| .. || |    |..|.|||||||. ||.....||.||.|||.|..|||||.|..
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NAQIIVMLPDNQSL-AEDEFVYWPSREE--SMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVI
|...|||| . ..|  |. . |||. ..  |.... |||||.| .      .. .... ..|. ........|.||....||. ..|  ..| .|.|...
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

KEEALT--RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..   .  ..||..||   |   .|...|| .| .||| |. |||... |..  .|||...  |||.|.|.|.| 
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 1150-1414 6.4e-69 227.8 In-house 2-277 (284) alignment
Range on Protein: 1150-1414
Range on HMM: 2-277/284.0
LEKQFKLVTQCNAKYV-ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYIMGY-----YRSNEFIITQHPLPHTTKDFWRMIWDHN
||..|. ..... |.. ..  |....|..||| ....| .. || | .|.|  ...|||||||. ||     |....||.||.|||.|..|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AQIIVMLPDNQSLA-EDEFVYWPSREESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQ-DDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE
...|||| .  .   |  . |||. .|..... |||||.|..      .. .... . |. .. ......|.||....||. ..|  ... .|... ..|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

EAL--TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENEN---AVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
      ..||..||.  |   .|...|| .| .|||.|.    |||... |..  .||| ..  |||.|.|.|.| ....|
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0040438 (Phosphotyrosine protein) phosphatases II 1147-1414 6.9e-69 227.9 In-house 17-279 (317) alignment
Range on Protein: 1147-1414
Range on HMM: 17-279/317.0
KTRLEKQFKLVTQCNAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.|.|...|. . ...    ..  |....||.|||.....| .. || | ||.|  ..|||||||. |......||.||.|||.|. |||||.|... ..|
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLPDNQSL-AEDEFVYWPSrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTR
||| .   |  |  . |||. .|..... |||||.| .      .. |... . .| ..|.....|.||... ||  ..|  ... ..... ..|    .
vmLteleelgrekcaqYwpl.getltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.||..||   |   .|...|. .. .||| |. |||... |... .|||...  |||.|.|.|.| .. .|
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0043336 (Phosphotyrosine protein) phosphatases II 1132-1409 1.8e-68 226.3 In-house 4-275 (278) alignment
Range on Protein: 1132-1409
Range on HMM: 4-275/278.0
LHSYVNSILIPGVGGKTRLEKQFKLVTQCNAkyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTT
 ..... .| .. ..||.|...|. .....    ..  |....||.||| ....| .. || | .|.|  ..|||||||. || ....||.||.|||.|.
vkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPsrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISS
.|||||.|... ..|||| .   |  .  . |||  ..|.... |||||.. .      .. ...... .. ..|.....|.|.....||  ..|  .|.
edFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

TFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
 ........|   ...||..||   |   .|...|| .| .|||.|  ||.... |... .||| ..  .||.|.|.|.| 
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0036941 (Phosphotyrosine protein) phosphatases II 1143-1415 8.2e-68 224.2 In-house 8-281 (297) alignment
Range on Protein: 1143-1415
Range on HMM: 8-281/297.0
GVGGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN
.  ....|.|.|. .... . . ..  |....|.|||| ....| .. || |    .  |.|||||||. ||.....||.||.|||.|. |||||.|..|
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

AQIIVMLPDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLclsNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE
 ..|||| .  .|  |  . |||.  .||.... |||||.| .     ... .... . .. |.......|.||....||  ..|  ..| ...|. ...
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv...llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE---NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
  ..|...||..||   |   .|...|. .. ||||    |. ||.... |..  .|||...  |||.|.| |.| |. .|.
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

subfamily_PTPN1_pd Subfamily PTPN1 847-1121 4.1e-67 220.9 In-house 7-272 (290) alignment
Range on Protein: 847-1121
Range on HMM: 7-272/290.0
GFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
 ..| ...... .   .........|||. .||| ..  |||||.||.      ... |||||. |.  .  . || ||||| .| . ||.|.|||..  
lykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkska

IVMITNLVEKGRRKCDQYWPTENSE-----EYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF
.||. ..|||.. || ||||....|     |  .. |.| |....  |||| . . |           .  |. |.....|||.|||.||||     | |
vvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen...........lktqetreilhfhyttwpdfgvpespaaflkf

VR--RSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.   |.| .  .. ||...|||||.||.||....|..| .|..|    .|..   | ..| .|  |.|| .|  | . |.|| . 
lfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak

0045450 (Phosphotyrosine protein) phosphatases II 1137-1411 2e-66 220.2 In-house 16-304 (307) alignment
Range on Protein: 1137-1411
Range on HMM: 16-304/307.0
NSILIPGVGGKTRLEKQFKLVTQCNAK-YVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYI--------MGYYRSNEFIITQHP
  .|.    ..|.|.|.|. . ... . . |. .|....||.||| ....| .. || | .|.|. ...|||||||.         ||.....||.||.|
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEAT-QDDYVLEVRHFQCPKWPNPDA
||.| .|||||.|... ..|||| .   |.    . |||. .|..... |||||.|..      .. .... . .. . .......|.||....||. ..
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

P--ISSTFELINVIKE--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|  .......|. ...  |.|...||..||   |   .|...|. .. .|||.|.    ||.... |..  .|||...  |||.|.|.|.| |.
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPRD_pd Subfamily PTPRD 1146-1413 4.1e-66 218.8 In-house 21-283 (564) alignment
Range on Protein: 1146-1413
Range on HMM: 21-283/564.0
GKTRLEKQFKLVTQCnaKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
.....|...| ...   . ... .|.|..||.||| . .|. .. || | ...| .|.||||||.| || .....| ||.||..|..|||||.|..| ..
sdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsst

IVMLPDNQSLAEDEF-VYWPSREeSMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALT
||||   .   ....  |||... . ... .|||| .. .|     ....| .|.|. .... . |||.|.  .||. ..| | |   .||. ... . .
iVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel.....adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
  ||..||   |    |. ...  . .....|. ||..|. |..   |. .    |||.||..|.|  .. 
dagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

DSPc_SM00195 1150-1411 4.5e-65 214.9 In-house 2-262 (263) alignment
Range on Protein: 1150-1411
Range on HMM: 2-262/263.0
LEKQFKLVTQCNAKYvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
|...|. . . . .  |. .|.|. ||.||| . ..| .. || | . .. .|.|||||.|| |. .....|.||.|||.| .|||||.|... .|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

PDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDG
 ...    |    |||.  ..... . ..|.|....       ..||.... |......   .|...|. .||. ..|   .|..||....|..  | .|
teeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|..||   |   .|..... .. ..||.|. ||.|.. |..   |||...  |||.|||.|.| ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1150-1411 4.5e-65 214.9 In-house 2-262 (263) alignment
Range on Protein: 1150-1411
Range on HMM: 2-262/263.0
LEKQFKLVTQCNAKYvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
|...|. . . . .  |. .|.|. ||.||| . ..| .. || | . .. .|.|||||.|| |. .....|.||.|||.| .|||||.|... .|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

PDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDG
 ...    |    |||.  ..... . ..|.|....       ..||.... |......   .|...|. .||. ..|   .|..||....|..  | .|
teeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|..||   |   .|..... .. ..||.|. ||.|.. |..   |||...  |||.|||.|.| ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0039614 (Phosphotyrosine protein) phosphatases II 1141-1414 6.5e-65 214.8 In-house 25-292 (297) alignment
Range on Protein: 1141-1414
Range on HMM: 25-292/297.0
IPGVGGKTRLEKQFKLVTQCNAkyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYIMGYYR-SNEFIITQHPLPHTTKDFWRMI
.    .||.|...|. . ...    ..  |....||.||| ....| .. || | |..|.  ..|||||||. ||.. ...||.||.|||.|..|||||.
lekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WDHNAQIIVMLPDNQSLAEDEFVYWPSREEsmNCEAFTVTLISKDRlclsnEEQIIIHDFILEAtqDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVI
|... ..|||| .   |    . |||....  ... |||||.. .      .. ...  . ..   ......|.|||...||  ..|  ... .|... .
weqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkveh.....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelv

KE--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.|  ..| ..||..||   |   .|...|. .. .||| |  |||... |... .|||...  .||.|.|.|.| |...|
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_CG7180_pd Subfamily CG7180 849-1123 1.3e-64 212.7 In-house 16-293 (296) alignment
Range on Protein: 849-1123
Range on HMM: 16-293/296.0
SEDFEEVQRCTADMNI-TAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHsdYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
   .. . . |. ..| .  .  . ||. |||..... ||. || |. | |.....  |||| |||.. | |.|| |..| |.| ..|||.......  .
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMITNLVEKGRrKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKgRQNERVVIQYHYTQWPD-MGVPEYALPVLTFVRRS-
|..|.  .  . .. .||| .  |.||.|.| . ..|  |  . | | .  . |  ... ..    ..|.| ....|.|.    ||  .  .. ..||  
vvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqv.kaetRivklfqlteWeledkvPlstnalielrrrvr

-SAARM---PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK
    ..   ||.|||.|..| |..|.| |. ||  |.... .  |.| ...| .| .|. ||.. |.| .| | ||||.| .
lwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_PTPN13_pd Subfamily PTPN13 848-1120 9.7e-64 210.3 In-house 13-269 (273) alignment
Range on Protein: 848-1120
Range on HMM: 13-269/273.0
FSEDFEEVQRCTADMNitAEHSNHPENKHKNRYINILAYDHSRVKLrplpgK-DSKhsdYINANYVDGY--NKAKAYIATQGPLKSTFEDFWRMIWEQNT
 .|.|.|..   .  .  .| ... |||.|||| |.| ||..||||     . ..    ||||...     ..   |||.||||  | .|||.|.|||..
Paeefkelrelkpldt..cevgkkkenkdknryrnvlPydetrvkl.....gdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

GIIVMITNLVEKGRRKCDQYWPTENSEEYgNIIVTLKsTKIHACYTVRRFSIRNTKVKKGQKGNpkgrqnERVVIQYHYTQWPDMGVPEYALPVLTFVRR
 .|.|.|. .|||. ||..||| .....   .   |.  .         |..|. .||. . |.       | | . ....||| |||  |...|.||..
eviamvtlekekgkvkchrywPesknkkl.kvsnrle.vellkvqkldgfvvralavkdsesge......srevahlnfvkwPdhgvPssaaellqfvae

SSAARMpETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||.||.||.|.|| .|. |. .  ..|   ....| ||. .|||..||||.. |.||..
vrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 827-1155 2.4e-63 208.9 In-house 3-272 (392) alignment
Range on Protein: 827-1155
Range on HMM: 3-272/392.0
AIPVKQFVKHIGelysNNQH--GFSEDFEEVQRCTADMNitaEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIAT
 ||| ||   .     .|.|   |.|.| ..    .  .     .... |..|||| ||| || .||||  .   |. .|||.|| |.....  |||||.
pipvaqfpafve....knrhsalffeefhdlpgpdiypq...tvaqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekayias

QGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGrrkcdqywptenseeygniivtlkstkihacytvrrfsirntkvkkgqkgnpKGrQNERVVIQYHYT
|||  ....|||||....|.  |.|.|.| |                                                      || .. | | |.|.|
qgpnaaslddfwrmvfqenvttiamvtklkegd....................................................kg.ddartvaqfhft

QWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKE
.||| .||...  .| |..  .|     | |...||||||||||  | |||.. . |    |.|. |.  || .| |.|||.||| ||. |.|| .| ..
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn

TEVSSNQLHSYVNSILIPGVG-GKTRLEKQFK
| .   ..  ... .   . | ....  |.|.
tlipvvhftdhlqdlstssdGdvrskqlkefr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 871-1118 8.9e-63 206.8 In-house 17-262 (270) alignment
Range on Protein: 871-1118
Range on HMM: 17-262/270.0
HPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN
.  .|. ||| .||   ..||.| .|     ... ||||||| |...  |.|||..|||..| ..|||||||...  |||.|.|.||||.||..|||.|.
aargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

SE----EYGNIIVTLKSTKIHACYTvrrfsirNTKVKKGQKGnpkgrQNERVViQYHYTQWPDMGVPEYAL------PVLTFVRRS--SAARMPETGPVL
 |    |.|.| |.  |.. .  |         |...  .||     ...|.|  ..|..||| |||. .        .|. .|    |  .. ...|.|
kekvkledgkikvlalseekeegyi.......ltrlrleekg.....eerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePll

VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||||||||||| |..| ... .. .. |.||  ....| .|  |||. ||| |.. |..|
vHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 840-1119 9.4e-63 206.7 In-house 12-292 (301) alignment
Range on Protein: 840-1119
Range on HMM: 12-292/301.0
LYSNNqhgFSEDFEEVQRCTADMNiTAEHSNhpENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMI
 .||.   |.|...|... . . . | ..|.  |||. ||. ||  ||. |. |.| |  |... .||||.|.|||...|..||.|||.|.|  ||||.|
khsnk...feeqykelkegedksc.tvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

WEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK----GQKGNPKGRQNERVVIQYHYTQWPDMGV-P
|.. .  |||.||| |. . || ||||.  ..|||.|.. |||......  ...|..... ... .     .| . | ... . |.|.. |.||. || .
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
|..  .        . . .. |||.||||..|.|.|.|. ..  | | |    |.| .  | .| ..   |.| |||..|.|.. . 
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

Carb_anhydrase Eukaryotic-type carbonic anhydrase 60-320 2.8e-62 197.3 Pfam-A 1-255 (256) alignment
Range on Protein: 60-320
Range on HMM: 1-255/256.0
WAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSnktWMKNTGKTVAILLKD---DYFVSGAGLPGRFKAEKVEFHWGHSN
|.|.   ..|.| .   .. |..||||.|  . |.. .. ..|.| . . ..     . |.|..| . |.|   .  .||. |.. ...... ||||.|.
WgyeeeaeeeewsklypiakgerqsPiniktkeakydpsLkplslsydeatak...eivnnGhsvqvelddssdksvlsggpleasyrlkqlhfHWgsse

gSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSpRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPAsLGSYYRYTGSL
 . ||||...| ....|. .  .|   ..|...|....  .  .... .|  . |..|. ..  |. . ...|.. |  | ...|||. |  |..|.|||
.ekGsEHtvdgkkyaaElHlvHwnsskyksvkeAvkkedglAvlgvllkvg.keneelqklvdaLeeiktkgksatltnfdpstllPk.lrdywtYeGsl

TTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSveyLRNNFRPQQRLHDRVVSKS
||||..| | |||.. |. .| .||... | ........ ..   | .|.|| | |.|||| .|
ttPpleEsvtWivlkepikvsseqllklrslllsaegeeeve...lvdnyRplqpLkdRvvras

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 843-1134 1.8e-61 202.6 In-house 6-280 (283) alignment
Range on Protein: 843-1134
Range on HMM: 6-280/283.0
NNQHGFSEDFEEVQRCTADMNITAehsnHPENKHKNRYINILAYDHSRVKLRPLPGkdskhsDYINANYVD---GYNKAKAYIATQGPLKSTFEDFWRMI
||.. | | ....     | .|..      |||.|||. .|...|  ||.|....       ||||| ..     |.. | ||..|.||. |  |||.|.
nnnklfrevlkrlsvpdldadias....adenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALPVL
....   |||.|.| |  | || |||| . ||.||.  |||.    .  .... . .|.              ... ..  | . .| ..|       ..
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..........ssakstlllahyqvidWleygeqaiinslv

TFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHS
 | .  |  .  . ||..||||.|.|||...| . . ..... .| |.|   .| .| ||  .||| .|| ..|.. ||  |  .|..   .|.|
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs

0040439 (Phosphotyrosine protein) phosphatases II 1166-1411 2.3e-61 202.9 In-house 2-246 (249) alignment
Range on Protein: 1166-1411
Range on HMM: 2-246/249.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP
|.  |....||.|||.....| .. || | .|||. ..|||||||| |||....||.||.|||.|..|||||.|... ..|||| . . |  |. . |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE--EALTRDGPTIVHDEYGAVSAGM
. ..|.... |||||.| .      .. ...  . |. ..|. ...|.|.|...||  ..|  .......|. ...  |.| ..||..||   |   .|.
l.ggsleygdftvtllsvev.....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
..|. .. .||| |. ||.... |... .|||...  |||.|.|.|.| |.
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRN_pd Subfamily PTPRN 841-1118 2.1e-60 198.9 In-house 24-290 (297) alignment
Range on Protein: 841-1118
Range on HMM: 24-290/297.0
YSNNQHGFSEDFEEVQRCTADMNiTAEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYV-DGYNKAKAYIATQGPLKSTFEDFWRMI
. .|.. .....| . .  |. . |.| .....| .|||. ..|.||||||||.     ....||||||  . |   .| ||||||||| ||  |||.|.
hlknkdrlekewealcayeaeps.tkevakaeknvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmv

WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPV
||| . .||..|.| |.| ..|..||| | || |.   | | | .| .  | || | ..| .            .. | | |.|.  ||..|||  | ..
weqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq...........tsetrtvtqfhflswpeegvPasaksl

LTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI-KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
| | |.   .    . |..||||.|.||||.||.|| .|... |    ...   |.|.| ||. ||.|..|. |.  |. |
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

0045098 (Phosphotyrosine protein) phosphatases II 1144-1413 9.9e-60 197.6 In-house 5-274 (278) alignment
Range on Protein: 1144-1413
Range on HMM: 5-274/278.0
VGGKTRLEKQFKLVTQCNakyVECFSAQKECNKEKNRNSSVVPSERARVGlaplpgmkgtDYINASYIMGYyrSNEFIITQHPLPHTTKDFWRMIWDHNA
  ....|| .|.|.. ..    |.. |....|..||| ....| .. ||           ||||||||.||  ...||.||.|||.|. |||||.|... 
asldlllefefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgi

QIIVMLPDNQSL-AEDEFVYWPSrEESMNCEAFTVTLISKDRLclsneEQIIIHDFILEAT----QDDYVLEVRHFQCPKWPNPDAPISS----TFELIN
..|||| . . |  |  . |||. ..|.... |||||.| ..|     . ......... .    .|.. ..|.|.... ||  ..| ..     .||..
tvivmltelvelgrekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

VIKEEALT-------------RDGPTIVHDEYGAVSAGMLCALTTLSQQLenENAVDVFQVAKMINLMRPG-VFTDIEQYQFIYKAMLSLVST
 |.|   .             ..||..||  .|   .|.|.|. .. ..|  |. ||.... |..  .||| ...  |||.|.|...| |.. 
firealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

Y_phosphatase Protein-tyrosine phosphatase 1175-1408 1.9e-58 193.1 Pfam-A 1-234 (235) alignment
Range on Protein: 1175-1408
Range on HMM: 1-234/235.0
NKEKNRNSSVVPSERARVGLaplPGMKG-TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP-SREESMN
||.|||.....| .. || |    | .| .|||||.|..|| ....||.||.||..| .|||||.|... ..|||| ...    |    ||| ..|||..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CEAFTVTLIskdRLCLSNEEQIIIHDFILEATQDD-YVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLS
.. ..|.|        ..|........ |. ....    ||..... .||. ..|   .| ..||. ....  ...||..||   |.  .|...|| .| 
ygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.|||.|. |||.|. |..   |||.....|||.|.|||.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1175-1408 1.9e-58 193.1 In-house 1-234 (235) alignment
Range on Protein: 1175-1408
Range on HMM: 1-234/235.0
NKEKNRNSSVVPSERARVGLaplPGMKG-TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP-SREESMN
||.|||.....| .. || |    | .| .|||||.|..|| ....||.||.||..| .|||||.|... ..|||| ...    |    ||| ..|||..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CEAFTVTLIskdRLCLSNEEQIIIHDFILEATQDD-YVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLS
.. ..|.|        ..|........ |. ....    ||..... .||. ..|   .| ..||. ....  ...||..||   |.  .|...|| .| 
ygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.|||.|. |||.|. |..   |||.....|||.|.|||.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 1169-1410 2.4e-58 192.8 In-house 3-242 (245) alignment
Range on Protein: 1169-1410
Range on HMM: 3-242/245.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSrE
.|....||.|||.|...| .. || | | .|  ..|||||||. ||.... ||.||.|||.|..|||||.|... ..|||| .   |  .. . |||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

ESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEAL-TRDGPTIVHDEYGAVSAGMLCAL
||.... |||||.| .      .. ...  . .. ..||...||.|...  ||  ..|  ... ..... ...    ...||..||   |   .|...|.
esltygdftvtllseeh.....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

TTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .. .||| |  |..... |... .|||...  .||.|.|.|.| |
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_PTPN14_pd Subfamily PTPN14 850-1119 1.3e-57 190.1 In-house 27-295 (300) alignment
Range on Protein: 850-1119
Range on HMM: 27-295/300.0
EDFEEVQRCTADMNitAEHSNHPENKHKNRYINILAYDHSRVKLRPlpGKDSkHSDYINANYVDGY--NKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
 ..|....  .| .   . .. |||..|||. ..| |...||.| |   |.. ...||||  .      | . ||..||||. | .|||.|.|||.. .|
teyeripkkredal..lstaklpenaeknrfkdvlPyednrvelsp..tken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

VMITNLVEKGRRKCDQYWPTE----NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkgrqnERVVIQYHYTQWPDMGVPEYALPVLTFVR
||.|.  |.|. |. .|.| .    .. |.|.  || | ..   ... . . ..    |.           || |.   || ||| ||||   . | ...
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske...........ertvwhlqytDWpdhgvPeDvkgflsyLe

------RSSAARMP---ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
      | .   ..   .  ||||||||||||||  |. | ... ..   ....   |...|.|| .||||  || |....|.. 
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1146-1413 3.9e-57 188.7 In-house 18-282 (318) alignment
Range on Protein: 1146-1413
Range on HMM: 18-282/318.0
GKTRLEKQFKLVTQCNAKYVECFSaQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|.. |..... .......  .  |  ...|| |||   ... ...|| | .| | .|.|||||.|| || |....| .| |||.| .|||||.|. |...
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLPDNQSLAEDEF-VYWPSReESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISStFELINVIKEEALTR-
|||| . .  . .    ||||. .|.. .. .|.| .. .|     .. ..  | .. |. . . .|| ... .||. . | |.  .|......   .  
ivmltqeeergkakvhryWPsk.gsrsygklvvelkeevel.....sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaqq

---DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
    ||..||   |   .|. .|. .| .....|. |||||. |..   |. .    .||.|||...|  . .
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_PTPN23_pd Subfamily PTPN23 834-1119 5e-57 187.9 In-house 3-279 (288) alignment
Range on Protein: 834-1119
Range on HMM: 3-279/288.0
VKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYN-KAKAYIATQGPLKSTF
|... . . ... .. . |.|...  .  .     .    . .|||. .|| |||.|||||      ... ||||| .| .    .  .||||.||.|| 
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstl

EDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN--SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMG
 |||.|..|| . .|||...  |.|. |.|.|||...  ....|.. |||||..    .  | ....  ..           .. . |   ..|.||..|
nDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda...........davksvshlqltsWpelG

VPEYALPVLTF---VRR-SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS-TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
||.    .| |   |.   .| . .   |..|||||||||||.. .. . ..... .   ....  ....|.|| . ||..||. |  .| |||
vPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1141-1415 4e-56 185.4 In-house 19-287 (319) alignment
Range on Protein: 1141-1415
Range on HMM: 19-287/319.0
IpgvGGKTRLEKQFKLVTQCNAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD
     |.| |||.|||. . ...  .  ||.|| ||.||| . ... .|.|| |..|.|..|.||||||.| || . ..|| || || .|..|||||.|.
s...tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

HNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDY-VLEVRHFQCPKWPNPDAPISST--FELINVIK
... |.||| . .   . ..   ...|. ..   ..||| ....|     |..|| .. |.  ...    || |||  .||. | | ..|   .|.. |.
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel.....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir

EEAL-TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
.    | .|| .||   |.   |  ..|    .....|...|||...... . |. .    |||.|||.|.|  |.. .
ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0041856 (Phosphotyrosine protein) phosphatases II 874-1126 5.3e-56 184.4 In-house 1-177 (182) alignment
Range on Protein: 874-1126
Range on HMM: 1-177/182.0
NKHKNRYINILAYDHSRvklrplpgkdskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITnlvekgrrkCDQYWPTENseey
|..|||| .|| |||||            ..||||||...|. .|. .|||||||.||..||.||..|.. ..||..|         ...|||..     
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

gniivtlkstkihacytvrrfsirntkvkkgqkgnpkgrqnERVVIQYHYTQWPDMGVPEyALPVLTFVRRSSAarmpETGPVLVHCSAGVGRTGTYIVI
                                         || .|||.|..|||.|||.    .| |...  .    | ||||||||||||||||....
.........................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaa

DSMLQQikdksTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. |...      |..   .|..| .|.  |.|..||.|...|||| .|.|.|.
ylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

0051429 (Phosphotyrosine protein) phosphatases II 903-1121 5.2e-55 182.3 In-house 3-226 (272) alignment
Range on Protein: 903-1121
Range on HMM: 3-226/272.0
HSDYINANYVDGYNK---AKAYIATQGPLKSTFEDFWRMiWEQNTGIIVMITNLVEKGRRKCDQYWP------------TENSEEYGNIIVTLKSTKIHA
 |.||||..|.||..    .......|||. | .||||. .|..   ||......|.|| |||.|||            .. . .||.. ||| |.... 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

CYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHYTQWPDMGVP-EYALPVLTFVRRssaarmpeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTV
.|..|.. ....             .. | | ..|||.|||.||| |. | .| ....         ||||||||||..||||..... .|... .   |
dyilrellltllls..........agearevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletiv

N--------VLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.        ........| || . |||||||.|...||||.. 
ddYlltnlyleeaveelraqrpgavqteeqylflyeallellr

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 849-1117 5.2e-53 174.7 In-house 13-274 (287) alignment
Range on Protein: 849-1117
Range on HMM: 13-274/287.0
SEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIV
 .... ... .  . .|   ...  . .|||| ..| .|..|| |   .    . ||||||||| .|.. .|.||.|||. .|  ||||...|...  ..
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg...elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MITNLVEKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkGnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRS-
..|  ||..| || .|||  .      |  .| |. .. .  |.|| . . . .      .     .. ||| |... .||| ...  |. .. ||    
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle......t.....rearvvkqldllswPdkvlaPtavglirfvldvk

---SAAR-MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
    .||   |.||..||...|.||.|... .  .... .|   |.|   . ..| .|. |||.  |. .. .|| 
qhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1148-1413 1.9e-52 173.3 In-house 27-292 (298) alignment
Range on Protein: 1148-1413
Range on HMM: 27-292/298.0
TRLEKQFKLVTQCNA--KYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|.....|. ... .   .  |   |.|. ||.||| ....... .|| |    . . .||||||.. .| ..| ||.||.||..|..|||||....... 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt

IVMLPDNQSLAE-DEFVYWPSREeSMNCEAFTVTLISKDrlclsNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEeALT
|||| . . | . .   |||... . . . .||.| ||.     .  ..|.  .... .. .   |||...  .||. ..|   .| ..|.. ..    .
iVmltnleeldktkyhkywPdeg.ketygeitvsllske.....efadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

RDG--PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
. |  | ||.   |   .|  .|. .. .....|. |||||| |..   |||. .  ||| |||.|.|  ...
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_PTPRK_pd Subfamily PTPRK 1169-1409 1.4e-51 170.2 In-house 37-275 (314) alignment
Range on Protein: 1169-1409
Range on HMM: 37-275/314.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPsrE
.|.|. |.||||   ... .|.|| | .. |   .|||||..| .| |...||.||.||..|.|||||...|.|.  |||| . .. .      |||  |
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..e

ESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEA--TQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLCA
...  . . |.|.. .      ......  | .|    . . . |||.||  .||. | | | |  ..|.  .|.    ..|...||   ||  .|. .|
dtevygdikvelvetel.....laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

LTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.... . .|.|. ||||...| .   .. .    |||.||| ..| 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

0049772 (Phosphotyrosine protein) phosphatases II 863-1126 8.5e-51 168.9 In-house 35-286 (314) alignment
Range on Protein: 863-1126
Range on HMM: 35-286/314.0
NITAEHSNHPENKHKNRYINILAYDhSRVKLRPLPGKDskhSDYINANYVDGYnkaKAYIATQGPLKSTFEDF----------WRMI--WEQNTGIIVM-
. |   .....|..||||..|| .| .||.|  ||...   ||||||.||||.   ...|||||||. |..||          |||.  ...|. .||| 
eltilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------ITNLVEKGrrkcdQYWPTENSEEYGniivtlkstkihacytvrrfS-------IrntkvkkgqkgnpkgrqnERVVIQYH
                    ...| ..|      ... .. |..                     .                          || .|.|.
rdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf..................erlgikyl

YTQWPDMGVP--EYALPVLTFVRRSsaarmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKdkstVNVLGFLKHIRTQRN-----YLVQTEEQYIFIHDA
.. .|| ..|  |. . .| |...      .. |||||||.||.|||||..|.. .. . .    |..   |...| .|       .... |||.||..|
ripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilea

LLEAILGKETE
|||..  ....
lleylkflkkf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 831-1124 9.4e-51 167.4 In-house 7-291 (305) alignment
Range on Protein: 831-1124
Range on HMM: 7-291/305.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTaDMNITAEHsNHPENKHKNRYINILAYDHSRVKLRPlpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKS
|| .| . .   .  .|. ..|  ..|   |..       . ....|||| ..   |. ||||..     .   .|| ||||    ..| .| || ||. 
kqilkfvkrtlekgpaglraefvamkrfn.dfekmkaf.keaqeagknrykdvgcldnnrvkleg.....pwpheyihanyvstptnpkrfictqaplek

TFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK-STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDM
|  ||| | ....   | |. ||.||| .|| .|..... ..        | | |. .. |..  .  ..||.. .       .. | | .||. .||| 
tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdr

GVPEYALPVLTFVRRSsaaRmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVN-VLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKE
|||   | .| .. ..   | |  ||. ||||||.||||. .... .|.|.     ..     |..|| |||  .||..||.|.|. .|. .. |.
gvpaadlailelleka...r.pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk

0036282 (Phosphotyrosine protein) phosphatases II 904-1114 3.1e-50 165.6 In-house 2-164 (174) alignment
Range on Protein: 904-1114
Range on HMM: 2-164/174.0
SDYINANYVDGYNKAKAYIATQGPLKstfedFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTenseeygniivtlkstkihacytvrrfsirntkvkk
||||||...|..   . .||.||||.     ||.|..|..  ..|| ....|.|. || .|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALpVLTFVRRSSAARMP-ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKdKSTVNVLGFLKHIRTQRNYL
      .    || .|||.|. |||.|||. .  .|.||..   |.   . |||||||||||||||| .... ||....  |.|..| ... .|.|| . 
......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VQTEEQYIFIHD
|||..||.|...
vqtpsQyrflyy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 848-1127 5.1e-50 165.2 In-house 18-284 (307) alignment
Range on Protein: 848-1127
Range on HMM: 18-284/307.0
FSEDFEEVQRCTAD-MNITAEHSnhpeNKHKNRYINILAYDHSRVKLRplpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
. ..|... . | . ... | ..    | .|||| .. . |..|. ..     |   |||| |||.    | | .|..||||..|  .|| |. ...   
lvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMITNLVEKGRRKCDQYWPTENSEEygNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVrrsS
..|. ...| .. ||.|||| |. ..  .. .    |   |   .....  .  ..  .  . .  |. | . .. ...||| |||.  |  . ..   .
vimlckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlinvttl.kvdwaqksrtiqhlqwenwpdrgvpqinltainll...e

AARMpETGPVLVHCSAGVGRTGTYIVIDSMLQQ-IKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
| |  .| ||.|||||||||.|| . |  . .. |. .   ..  ... .|.||.| .||| ||...|  |||  | .  | 
avry.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket

subfamily_Ptp69D_pd Subfamily Ptp69D 1151-1412 1.1e-49 164.2 In-house 25-287 (307) alignment
Range on Protein: 1151-1412
Range on HMM: 25-287/307.0
EKQFKLVTQCnAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP
.| .. . .      ..  ..|. |. |||   ... .. || |....| . .||||||.| ||  ...||. | |.  | .||||||.. . ..|||| 
akeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

DNQSLAED-EFVYWPSReESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEALTRDGPT
. .   ..    |||   . .. .   |.|.|...     . .. .     |... .   .|  ..   |..  .| ..   ..||. ..|   .  .| 
nlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPi

IVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
.||   |.  .|.. ||. | |||..|. ||.|.. | .   |. ... .|||.|.|.|.|   |
vvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0037934 (Phosphotyrosine protein) phosphatases II 1167-1410 3.6e-49 162.9 In-house 2-241 (243) alignment
Range on Protein: 1167-1410
Range on HMM: 2-241/243.0
CFSAQKECNKEKNRNSSVVPSERARVGLaplpgmKGTDYINASYIMGYyrsNEFIITQHPLPHTTKD----FWRMIWDHNAQIIVMLPDNQ-SLAEDEFV
.. |....|..||| |...| .. || |      .|.|||||..|...   . .|.||.|||.|..|    ||||.|... ..|||| . .   .|. . 
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsreESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQ-DDYVLEVRHFQCPKWPN----P-DAPISSTFELINVIKEE-----ALTRDGPTIVH
|||   ...... |||||.|         ...... . || .. ||....|.|...  ||     .  ... . .. .. . ||     || ..||..||
ywp...gevtygdftvtllseeh.....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

DEYGAVSAGMLCALTTLSQQLeneNaVDVFQVAKMINLMRPG-VFTDIEQYQFIYKAMLSL
   |   .|.|.|. .. ..|   . ||.... |..  .||| ...  .||.|.|.|.| |
CsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPRB_pd Subfamily PTPRB 1146-1416 6.1e-49 161.6 In-house 23-290 (293) alignment
Range on Protein: 1146-1416
Range on HMM: 23-290/293.0
GKTRLEKQFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
 ..|. .... . . . .  .. .|....|..||| . ..| . .|| ||.| . .|.|||||.|| ||   .||| || |||.|..|||||.|.....|
sdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILEAtqDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEA--
|||| .           |||. ||...    .|||....     . |. .|... .|   ..   .||...   ||. . | ..    .... ..|..  
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee.....eledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKEN
 ....|..||   |   .| . || .| |..|.|. ||.| .   .   |  .    .|| ||....|.|...||.
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_PTPRA_pd Subfamily PTPRA 1165-1409 1.3e-47 157.3 In-house 48-293 (330) alignment
Range on Protein: 1165-1409
Range on HMM: 48-293/330.0
VECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYW
  .  |.|| ||||||   ..| . .|| |... |.. .||||||.| || . ..|| .| |. .| .|||||||..... |||| . .   |.    ||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PSrEESMNCEAFTVTLISKdRLClsneEQIIIHDFILE----ATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEALTRDGPTIVHDEYGAVS
|. | ..     .|..  .  ..    ... . .|...    ||... .  || |    ||.   |. .   ..|.. .|.      || .||   |.  
Pd.eGlvtyGnirvevede.tvl....vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

AGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.| ...| .. .... |. ||||.. | . | || .    |||.||||..| 
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1170-1415 1.7e-47 156.8 In-house 4-246 (250) alignment
Range on Protein: 1170-1415
Range on HMM: 4-246/250.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSrEES
|.|  |||||| . ... . .|| | .  | | .||||||.. ||  .. ||.||.||..|..|||||....... |||| . .   .    |||  |..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.eka

MNCEAFTVTLISKDRLClsneeQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALT-RDGPTIVHDEYGAVSAGMLCALTT
 .    ||.| ||.         .... ..|  ..      ||...   ||.   |    . .||.. .. .     ..| ||.   |   .|  .|. .
ekyGdvtvsllskeefa.....dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
. ..|..|. ||||.| |..   ||.. .  ||| |.|...|  . . |
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 845-1118 3.2e-47 155.8 In-house 5-257 (267) alignment
Range on Protein: 845-1118
Range on HMM: 5-257/267.0
QHGFSEDFEEVQRCTADMNITAeHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNT
.  . ..||.... . . .  .  |   .|. .||. . | ||..|| ||       |  .|||| ||.||.. .|.|.||.||| |  ||. .| .|. 
eceiekefelikkisdtsstis.qsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

GIIVMITNLvekGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHACYTVRRFSIrntKVKKGQKGNpkgrqnervVIQYHYTQWPD-MGVPEYALPVLTF
 .||..|.    .  .  ..|| .  ....| .. |     |    | .  . .   |.|.    |         |  |.| .|        |  |..  
pvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahn.........vtlyyykkwnintnnkpylkplfgi

VRRSSAArmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
. .          |..|.||.||||.||..||||.|...|  .....  ||..|| ||  ||.| |.||.||. | |
laknqle..ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 831-1118 4.1e-47 155.2 In-house 12-281 (290) alignment
Range on Protein: 831-1118
Range on HMM: 12-281/290.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNiTAEHSNHPENK--HKNRYINILAYDHSRVKLrplpgKDSKHSDYINANYVDGYNKakAYIATQGPL
. | |   .  . | .... .. |  .     .   | .   .|   .|||| ..   | .|| |     ||  . ||. ||||.| .    .| |||.|
eafekfasdvvkknvdelakeyleklkpylpvq.ylerkifdkntefkknrykdvvcndktrvil.....kdGydGdyvhanyvkGlka..mfiltqGal

KSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE--EYGNIIVTLK-STKIHACYTVRRFSIRNTKvkKGQkgnpkgrqnERVVIQYHYTQ
|.|  |.|||. ....  |||. .|.|.|. ||.||.| .. |   .|.| |.   ...  |    . .|.|. .  .|.         | ..  ..   
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkd..sGk.........ehklkhlkiks

WPDMGVPEYALPVLTFVRrsSAARMpeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||  |.  .| .|  .|  .  ..  .||| ||||||.|||||.. |.  || . |   ...|.  . .|  |   || . ||. . ..||.
wpdksvalstlallrtlr..ilrka..sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1145-1413 3.2e-46 152.7 In-house 18-281 (288) alignment
Range on Protein: 1145-1413
Range on HMM: 18-281/288.0
GGKTRLEKQFKLVTQCNAKYVECFSaQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 ..| ...... ... . .  .. . ..  |..|||   ..| .  || |  |.  .|.|||||||| |. .....| || ||..| .|||.........
rnrtgfseeynsLaalektksvtag.rlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

IIVMLPDN-QSLAEDEFVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILEatQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEAL
 |||| .  .   .    |||. ..  |   .||||...      ..|... . ..||  ..   ||. ..|   ||. . | |..  .||.. .|    
tivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.....eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
   || |||   |   .|   || .| ...|.|. .||. . . .   |. .    .||.|||...|||.. 
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_CG7180_pd Subfamily CG7180 1155-1412 4.1e-46 152.0 In-house 20-291 (296) alignment
Range on Protein: 1155-1412
Range on HMM: 20-291/296.0
KLVTQCN--AKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN
||. .     .  .|  . .. |.||||.  ||| . .|| |  | | . .|||||.|. .. . .|.|.|. |  .| ..|||...|.... .|.| ..
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

QSLAEDEFVYWPSREeSMNCEAFTVTLISKDRLCLSNEEQIIIHDFILE--ATQDDYVLEV---RHFQCPKWPN-PDAPIS--STFELINVIKEE---A-
 . |.    ||| .    .   . | ..... .   .  .. .   |.   ... . . |.   ..||  .|.     |.|  .  ||.. ..     . 
fdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
     ||..|. . ||  .|. .|.    ...|.|. ||||. .|..   ||..   .|.|..||  .|  | 
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1148-1414 1.2e-45 151.0 In-house 22-286 (305) alignment
Range on Protein: 1148-1414
Range on HMM: 22-286/305.0
TRLEKQFKLVTQCnAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV
. ||.|.|....   .   ..  .|| ||.|||...... .  |. |.. . .. .|||||||. || |....|..| ||..| .||||.|..   . ||
kgleaqykslyee.ee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLPDNQSLAEDE-FVYWPSREES-MNCEAFTVTLISKDRLclsneEQIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEALT
|| . .   .|    ||| ..   .. . |.|.| |.        .. |. .. .    .|.    | ..|  .||.   | .  |  .||. ....   
mltklveggkdkCrqYWpesktekkefgefsvelksekta.....sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

RDG-PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
  | | .||   |   .|. .|.    ..|..|. ||||.| | .   |... .  .||.|.. |.  |. . 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0043147 (Phosphotyrosine protein) phosphatases II 902-1113 2e-45 149.9 In-house 3-154 (172) alignment
Range on Protein: 902-1113
Range on HMM: 3-154/172.0
KHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLvekgrrkcdqywptenseeygniivtlkstkihacytvrrfsirntkv
..||||||.|.|.| . . .||||||| .|..|||||..|.. ..||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

kkgqkgNPKGRQNERVVIQYHYTQWPDMGVPeYALPVLTFVRRSSA-ARMPETGPVLVHCSAGVGRTGTYIVIDSMLqqikdkSTVNVLGFLKHIRTQRN
         . . || .|||.|. |||.|||  .  .| |..     .   . |||||||||||||||| .... ||        ....  ....|..|.
......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRp

YLVQTEEQYIFIH
. ||...||.|..
gavqnpsqyrfly

0049260 (Phosphotyrosine protein) phosphatases II 911-1114 6.1e-45 147.9 In-house 1-144 (152) alignment
Range on Protein: 911-1114
Range on HMM: 1-144/152.0
YVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWptenseeygniivtlkstkihacytvrrfsirntkvkkgqkgnpk
..|||.. ...||||||.  |..|||||..|.. ..|||.|.|.|.|. ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

grqnervviQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLqqikdkSTVNVLGFLKHIRTQRNYLVQTEEQYI
         ||....|||.|||. .  .| ...    ..  . ||||||||||||||||..... ||        |... .....|..|.. |....|..
.........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlr

FIHD
|...
flye

0046846 (Phosphotyrosine protein) phosphatases II 901-1118 7.2e-45 148.2 In-house 9-171 (176) alignment
Range on Protein: 901-1118
Range on HMM: 9-171/176.0
SKHSDYINANYVDGYnkakAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYgniivtlkstkihacytvrrfsirntk
  ..||||||...|.    ..||||||| .|..||..|..|.. ...|..|..||.|| ||..||| . ....                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

vkkgqkgnpkgrqnervviQYHYTQWPDMGVPEYaLPVLTFVRRSSAARMPEtGPVLVHCSAGVGRTGTYIVIDSMLQqikdKSTVNVLGFLKHIRTQRN
                   ||... |||.|||..   .|....    |.    ||||||||||.|||||..... .      .  ..|.  |...| || 
...................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRp

-YLVQTEEQYIFIHDALLE
 . |||.||| |.....|.
lgavqtpeQyrflyefell

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 869-1118 3.3e-44 145.6 In-house 32-267 (281) alignment
Range on Protein: 869-1118
Range on HMM: 32-267/281.0
SNHPENKHKNRYINILAYDHSRVKLRP-LPGKDSkhSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT
 |.| |..||||.|| . | |||.|.  .| |.|  .||| |||.      . || |||| | |  |||||||..||  |||. ...|  | || .|.| 
fnqpvnnkknrylnipcldisrvqlkvkmpnkns..tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

enseeygNIIVTLKSTKIHACYTVR--RFSIRNTKVKKGQKGnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAaRmpETGPVlVHCSAGVG
       |  . |.  |.   |       |.  |...   .|      . |.. .. . .|||  ||| .  .|  .|.  | |   | || .|||||||
.......nahcclqfdklsvsyedstvnkslvttrlnlsyeg......etrlithwlwkewpdwqvpessevmlkilrkira.r..stppv.ihcsagvg

RTGTYIVIDSMLQQIKDKSTVN-VLGFLKHIR-TQRNYLVQTEEQYIFIHDALLE
|.|| . ..  || |. . |.  .   . |.| | |   ||| .||..|   ||.
rsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1147-1409 3.3e-44 146.5 In-house 33-289 (319) alignment
Range on Protein: 1147-1409
Range on HMM: 33-289/319.0
KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.|.|| .|. ...  ..  .   |  . ||.|||   ... ....| | .| |. ..||||||.. || | . .| .| ||. | .|||||||..|.  |
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLPdnqslAEDEFVYWPSREeSMNCEAFTVTLISkdrLCLSNEeqIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKE-EAL---
|.|       .    ||| .   .. | | | . |   .  ..|   .. |. |   ..   . ... |    ||.   | . . .|. ..|  . |   
vllt.....kdkcsqywplki.vikeerfkvkvds...veetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdy.psdlmrlvkkvrhltsk

-TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
     . .||   |.  .|.  .| .| .....|. |||... . .   |. .  |. ||.||| |.| 
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN12_pd Subfamily PTPN12 1150-1413 4.8e-44 145.4 In-house 10-279 (290) alignment
Range on Protein: 1150-1413
Range on HMM: 10-279/290.0
LEKQFKLVTQCNAKYV-----ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
..|.|. . ....||      .  ...|| |..|||   ..| . .|| |    . .| |||||..| | . . |.| .| |||.| .|||||||..| .
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknve

IIVMLPDNQSLAEDEF-VYWPSR-EESMNCEAFTVTLISKDRLclsnEEQIIIHDfiLEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEA
|.||.  .  |.      |||.. ||... ..|.|||......    .....|    |......   .|. |.  .||. . | |    .|||. ..|  
ivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav....dddflirt..LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 . | | .||   |   .| ..|.    ..|..|.    .|||..   .   |. .    |||...|||...||..
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1145-1413 5.1e-44 145.3 In-house 17-285 (290) alignment
Range on Protein: 1145-1413
Range on HMM: 17-285/290.0
GGKTRLEKQFKLVTQcNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG--TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN
 |... ..||| . .  ..  .   .  . ||..|| . .|...  |. | |..| |    .||||.|| ||  ....|.|| |...| .|||..||...
kgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

AQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKDRLclsNeeQIIIHDFILEATQ-DDYVLEVRHFQCPKWPNPD---APISSTFELINVIK
  ||||| . ..  .     |||... ..  . |...|..   |   |  ..|.  . .. .. ...  .| ..|   |.. .   .| ...  . ...|
vtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetl...n..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

EEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 .  . ... .||   .   ....||..|  .. . |  .||||| |     .||  .  .|||.|.. .|. ...
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1170-1410 8.8e-44 144.7 In-house 44-278 (315) alignment
Range on Protein: 1170-1410
Range on HMM: 44-278/315.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSRee
|.|  ||.|||   ... ...|| |  |   ...||.||..| || . . .| .| |.. . |||||......   |||| .  .  .     ||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

SMNCEAFTVTLISKDRlclsnEEQIIIHDFilEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTT
 .    .|||..|..      .... .  .    . .| . ||  ..   ||. . | ...   .||  .|    .  |. .|| . |   .| ...| .
kviyGkitvtrkseev.....nteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitlda

LSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
. .|.| |||.||... . .  .| ..   .|||||||.|.|  
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 849-1126 3.9e-43 142.2 In-house 27-295 (305) alignment
Range on Protein: 849-1126
Range on HMM: 27-295/305.0
SEDFEEVQRCT-ADMNITAEHSNHPE--NKHKNRYINILAYDHSRVKLRplpgKDSkHSDYINANYVDGY-NKAKAYIATQGPLKSTFEDFWRMIWEQNT
 |.| .. . |  ||  .|  .|.    .. |||| .. . |.| |||     | |  |||| ||||       | .|..||||  | ..|| |. ... 
reefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkld....kps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

GIIVMITNLVEKGRRKCDQYWPTENSEEygniiVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK-GRQnERVVIQYHYTQWPDMGVPEYALPVLTFVr
  |||. . || |. || ||||. . |      ..|||  .    .  .   |.....         | | .  | . ..|.||| |||   |  | .. 
eqivmlcktvelgklkcaqywpaaqgek.....lelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslell.

rsSAARMPeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKD-KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
  || |     |..||||||.||||| . |. .|..| . |.   .  ..| .| || . .|.. ||.|||  .|. .| |  |
..sairgs.kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1162-1409 5.1e-43 142.6 In-house 12-253 (284) alignment
Range on Protein: 1162-1409
Range on HMM: 12-253/284.0
AKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPdnqslAEDEFV
..  .   |  . ||.|||   ... ....| | .| |. ..||||||.| || | . .| || ||. | .|||||||..|.  ||.|       .    
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq

YWPSREeSMNCEAFTVTLISkdrLCLSNEeqIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKE-EAL----TRDGPTIVHDEYGA
||| .   .. | | | . |   .  |.|   .. |. |   ..   . ..| |    ||.   | . . .|. ..|  . |        . .||   |.
ywplki.vikeerfkvkvds...veesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdy.psdlmrlvkkvrhltskenhranivvhcsagv

VSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
  .|.  .| .| .....|. |||... . .   |. .  |. ||.||| |.| 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 873-1117 7.2e-43 141.6 In-house 46-341 (350) alignment
Range on Protein: 873-1117
Range on HMM: 46-341/350.0
ENKHKNRYINILAYDHSRVKLR--PLPGKDSKH----SDYINANYVDGY------NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
|   |||| ||| |.||||||.  . . .  ||    .|||||||.         |    |||||.||.||..||...| . .  .|...|..|| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CDQYWPTENseeYGNIIVTLKSTKIHACyTVRRFSIRNTKVKKGQK------GNPKGRQNE------------RVVIQYHYTQWPDMG---VPEYALPVL
|..||.  .   | .| | |.|..   .  ..  |.. ..|||          . . ..|.             || | .. .|.|..    ||  |..|
cyrYWqegs...ydditvklaskwenim.gindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqal

T----FVRRSS---AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQ------QIKDKST-V--------NVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
     ..            .. |.|||||||||||||.. .||.|.      .....|. .         .   ....| ||  .||. .|.|||..|||
evkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall





subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1146-1413 6.4e-42 138.5 In-house 18-280 (287) alignment
Range on Protein: 1146-1413
Range on HMM: 18-280/287.0
GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|..  ..||... | . .  |   .  . ||.||| . ... .  || |      .  |||||..| ||  ...|||.. |. .| ..||..|.|.| ..
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVMLPD-NQSLAEDEFVYWPSREEsMNCEAFTVTLISKDRLCLSNEEQIIIHdfilEATQDDYVLEVRHFQCPKWPNPD---APISSTFELINVIKEEAL
|||| . ...  |  . |||. .  .    ....|.....     | .. ..    . ....  ..|. .|  .|..      | .. . . . .|..  
ivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevk....nknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
  ... .||   .   ..|.||  |  .. ..| ..||||| |     .||    .|||.||....|  ...
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_ptpA1_pd Subfamily ptpA1 869-1080 6.4e-41 135.4 In-house 42-256 (418) alignment
Range on Protein: 869-1080
Range on HMM: 42-256/418.0
SNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYnKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE
 ..  |  |||| |||  .|.||.|. .  .| . ||||||||.||    | .|.|||||  |  |||||.||.   ||||..   |. | |||.||| .
gdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

NSEEYGNIIVtlKSTKIHACYTVRRFSIRNTKVKKGQKGNPK--GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR---RSSAARMPE---TGPVLVHC
   |  .|    .  ..   |.|    . .   ..    | .     . | . ||.|  |||  .|... |.  ...         .|      |..|||
iggeqfsiyg..ngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGTYIVIDSMLQQI
|||||||||.     |....
sagvgrtgtfctavimmkkl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 867-1132 9.9e-41 134.3 In-house 45-301 (310) alignment
Range on Protein: 867-1132
Range on HMM: 45-301/310.0
EHSNHPENKHKNRYINILAYDHSRVKLRplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
 .  . .. ||||| ...  | |||||.      |.. ||| ||||      ...| .||||. |  ||||||... .  |... . .|.|| ||  |||
tyeaykkymhknrysdvvcldtsrvklk...idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp

TE-NSEEYGNIIVTL---KSTKIHACYTVRRFSIRNTKVKKgQKGNPKgrqNERVVIqYHYTQWPDMGVPEYAlpVLTFVRRSSAaRMpETGPVLVHCSA
.   .| || | ||     | ..  |     |   |  | . |  | |   . || .  .. .|||.|||.    . |  .|  | ..   ||..|||||
slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvde.qpanlk...elrvsl.ikwpnwpdrgvpdek..chtvpqrlla.qv.rhgpcvvhcsa

GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIlGKETEVSSNQL
|..|... . ..  .....    |..     ... .|   .||| ||..|.   .      ||||. . |
gkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa.rgetevaekil

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 869-1128 8e-40 131.7 In-house 38-279 (288) alignment
Range on Protein: 869-1128
Range on HMM: 38-279/288.0
SNHPENKHKNRYINILAYDHSRVKLRplpgkDSKHsDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE
... .|  ..|| |.   | .||||      |  .  ||.|| |   .  .  | .| ||..| | .|.|. |..   |||...|.|||..| ..|.|..
dsfianptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

NSEEYgNIIVTLKSTKIHAcYTVRRfSIRNTKVKKGQKGnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSsaarMPETGPVLVHCSAGVGRTG
  |.   |    . .| .    . .  .. . ..  ..|     ... .| . |. .|.| ||||  |. | .. .        . |..||.||||||||
lGeka.rigrlctvvkkkr.adidk.lvkvsllriskeg.....eekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtg

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVS
| |.|  .|.... .  . .  .|.. | .|   .||| ||...|  .|| .| |  .|.
tlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvl

0044763 (Phosphotyrosine protein) phosphatases II 886-1116 9.3e-40 131.5 In-house 2-167 (178) alignment
Range on Protein: 886-1116
Range on HMM: 2-167/178.0
YDHSRVKLRPLPGKDSkhSDYINANYVDGYnkakAYIATQGPlkstfEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSeeygniivtlkstki
.|..||.| .|.|  .  ||||||......     |.....|     .|......|.. . ||..|. .| |. |||.|||.|..               
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

hacytvrrfsirntkvkkgqkgnpkgrqnervvIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQikdksT
                                 |||... .||.|||.    .| ||.   .|. .. |||||||||||||.|| .... |...      
.................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....g

VNVLGFLKHIRTQRNyLVQTEEQYIFIHDAL
...   ....| .|.  |....|. ....  
lsleeaielvrerRp.ivpnpgqlrqLyefe

subfamily_PTPN23_pd Subfamily PTPN23 1144-1414 1.7e-39 130.3 In-house 11-283 (288) alignment
Range on Protein: 1144-1414
Range on HMM: 11-283/288.0
VGGKTRLEKQFKLVTQCNAKYVECFS-AQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYY-RSNEFIITQHPLPHTTKDFWRMIWDH
..||| |.|.||...| ..|  . .| |  ... ||||.  ..| ...|| |      .  ||||||.. .    . .||.|| ||. |  |||.|... 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

NAQIIVMLPDNQSLAED-EFVYWPSRE-ESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIK
 ...|||| ... | .     |||... |... ....||| |. ..     |. . ....||  . | | .|.| |  .||.  .|   .. ........
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.....ethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

E--EALTR--DGPTIVHDEYGAVSAGMLCALTTLSQQLENENA-VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.  ||  |  . | .||   |   .|... . .  ..||..|  .|. || . .   |  .  . ||..| |.|.|  .   
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv

subfamily_PTPN6_pd Subfamily PTPN6 1146-1415 4.1e-39 129.4 In-house 24-301 (306) alignment
Range on Protein: 1146-1415
Range on HMM: 24-301/306.0
GKTRLEKQFK-LVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLApLPGMKGTDYINASYIMGYYR--SNEFIITQHPLPHTTKDFWRMIWDHN
.|. .|..|. | .. . |...   ..|  ||||||  ...| . .|| |.  |...|.|||||.||..  .  ....| ||  |..| .|||||.|. |
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

AQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILE-ATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKE
...|||.  .   ...    |||. ||. .    .|| .|..     . .. |. .. ..  ....   ||....  .||. . | .     .... ...
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.....sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

EALT----RDGPTIVHDEYGAVSAGMLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
.. .    . ||..||   |    | .  . .| ...|.   .  .|. .. |..   | |.    .||.|.|||.   . ||.
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1174-1409 6.5e-39 128.7 In-house 27-266 (274) alignment
Range on Protein: 1174-1409
Range on HMM: 27-266/274.0
CNKEKNRNSSVVPSERARVGLAPLPGMK-GTDYINASYIMGY-YRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESM
 ...|||  ...| |..|| | .  . .  ..|||| || || ..|. .. || |||.| .||||||. ...|.|||| . .   |    ||.| .|.  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

NCEAFTVTLISKDRLClsNEEQIIIHDFILEATQDdyVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEA---LTRDGPTIVHDEYGAVSAGMLCALT
  | ..   |  .     ....  .. ..|. ...    .| |.  ..||. ..| .  . ..|.. ..|..    .. .|..||   |   .|.  | .
iserygdveikvekiv..erndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
   .||..|. |||...   . | | |.    |||..|..|.  
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1153-1409 3e-38 126.3 In-house 11-264 (283) alignment
Range on Protein: 1153-1409
Range on HMM: 11-264/283.0
QFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGmkgtDYINASYIM---GYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
... . . .    ..  |  . ||.||||  .|| .. || | ...     |||||..|.    | .....||.| || .| .|||.|..|...  ||||
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

PDNQS-LAEDEFVYWPSReESMNCEAFTVTLISKdrlclSNEEQIIIHDFILEAT--QDDYVLeVRHFQCPKWP--NPDAPISSTFELINVIKEEALTRD
   |  | .    |||.|  |..   |||||          ..  ||. ..|       . .| . |.|   |   ...|.| |   .  ||      ..
tklqedlrikCsqyWPkr.GsedyGeftvtlrke.....ttsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskk

GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
|| .||   |   .....|...  ...  |  ||||.| |..   |...    .||.......| 
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1161-1414 5.1e-38 125.9 In-house 37-287 (297) alignment
Range on Protein: 1161-1414
Range on HMM: 37-287/297.0
NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRsnEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF
.|.  .   |.|  | ||.| . ..|... || || .      ||.|||.. |.    ..| || | . | .|||.|..|.....|||| |..   .   
eaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkca

VYWPSREeSMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI----SSTFELINVIKEEALTR-DGPTIVHDEYGA
 ||. .  ...    .|.| | ..      |  |  .. ..  .      |. .|  .||. . .     ||  .||. ....  .. .|| .||   | 
ryWsdkg.vttfGdvsvvllsvser.....eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

VSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
  .|.|...     . ..|..||.|.. |..   || .    |||.|.|.|.|  ....
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_PTPN13_pd Subfamily PTPN13 1153-1412 9.5e-38 125.0 In-house 16-270 (273) alignment
Range on Protein: 1153-1412
Range on HMM: 16-270/273.0
QFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGmkgtdYINASYIMGYYRSNEF--IITQHPLPHTTKDFWRMIWDHNAQIIVMLP
.|| . .  ..  .| ...|. ||.|||   |.| ...|| |    |     |||||.|      .|.  |..| |||.|.||||.|.|. .|..|.|. 
efkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

DNQSLAE-DEFVYWPSREESM--NCEAFTVTLISkdrlcLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPiSSTFELINVIKEEALTRD--G
 ..   .     |||.....     . ..|.|.      . . ..  .... .. ..   . || |..  |||. . | ||. ||.....| .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellk.....vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvaevrrlqtdag

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
| .||   |   .|.| .. .. . .|... .|| .. . .   | ||    .|| |.|||.| ...
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1168-1409 1.1e-37 124.6 In-house 37-275 (315) alignment
Range on Protein: 1168-1409
Range on HMM: 37-275/315.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSR
 .|... | .|||   ..| ..||| |  .      |||||||| ..   . .| .| ||. . .|||||......  |||. . |         ||| |
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-EESMNCEAFTVTLISkdrlcLSNEEQIIIHDFILEATQDdyVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCA
  .|..  .. |.|.|     |.   . ..  ...  ...     |  ||  .||.  ..   || ..||  .| .  ... . .||   |.  .|....
kadsvefGsikvells.....leadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

LTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.    .|......||||.. |..   || .    |.| ||| |.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle

0051082 (Phosphotyrosine protein) phosphatases II 903-1117 3.1e-37 122.8 In-house 2-150 (151) alignment
Range on Protein: 903-1117
Range on HMM: 2-150/151.0
HSDYINANYVDGYnkakaYIATQGPlkstFEDFWRMIWEQNTGIIVMITNLVEKGrrKCDQYWPTENseeygniivtlkstkihacytvrrfsirntkvk
.|||||..||.|.     .....||     .||.....|..   ||......| |  .| .|.| ..                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

kgqkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAarmPETGPVLVHCSAGVGRTGTYIVIDSMLQQikdkstVNVLGFLKHIRTQRNYL
             . |...... ||| |.|..   || |..   .   .. ||||||||||.||||| .... ||..      |..   |...| .| ..
.............ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv

VQTEEQYIFIHDALL
||...|..|.. |||
vqpnqqflfqlfall

subfamily_PTPN9_pd Subfamily PTPN9 1166-1411 3.1e-37 123.2 In-house 33-290 (297) alignment
Range on Protein: 1166-1411
Range on HMM: 33-290/297.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWP
.   ... .| |||| . |.  ...|| || ... . .|||||... || . . || || ||..|..|||||.|.... .|||              |||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

SREESmnCEAFTVtlISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEE-------------ALTRDGPTIV
. |||  .. |.   .|  ..   .||.  .. . .. ....   .| |||   ||.   | |.   ........|.               ... | .|
leees..saefgd..lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|   |   .| ...|    ..||... |||... |..   |       |||.| |.|.|   
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1148-1413 2.3e-36 120.0 In-house 15-295 (301) alignment
Range on Protein: 1148-1413
Range on HMM: 15-295/301.0
TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV
...|.|.| ... . |  .    ... . ....| .|.. .|  .   |   .. ..||||||| || ....||..| |. .| .||||.||..  . ||
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLPDNQSL-AEDEFVYWPS-REESMNCEAFTVTLISKD--------RLC--LS--NEEQIIIHDFILEATQddYVLEVRHFQCPKWPNPDA---PISSTF
|. . .    .  . |||. ..|| .   |||||...         .|.  .    ... |.. |  ....     .|  .|  .||.      |     
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

ELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 . .||. .     || .||   .   .|. |...    |   |  |||||| | .   .||. | .||| .||...   .. 
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1169-1413 2.4e-36 120.0 In-house 32-279 (287) alignment
Range on Protein: 1169-1413
Range on HMM: 32-279/287.0
SAQKECNKEKNRNSSVVPSERARVGLAPlPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSRE
.|..  . .||| . |.| . .|| |.   | .|.||||| |. .| . ..|| .| |.. | .||||.......  ....  .   |  . . ||| ||
aaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

ESMNCEAFTVTLISKDRLclSNEEQIIIHDFILEATQDDYVleVRHFQCPKWPNPDAPIS---STFELINVIKEEALTRD----GPTIVHDEYGAVSAGM
  |    ..|.|...| .  . |  .     |   |..  |  |. ..  .||.  .. .        ..| .   |.||    || .|||. |.  .|.
vPmrvGGysvvlldydik..ePeygvralrlidletrearv..vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGi

LCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
| |. .| ..||.   ||| .|   .   | ..   . |....|.|. .   |
llatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1169-1411 2.5e-36 120.4 In-house 42-288 (325) alignment
Range on Protein: 1169-1411
Range on HMM: 42-288/325.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSR-E
 | |  ||.|||   ||. ...|| |  .     .|||||||.  . . . |. .| ||..|..|.||.. | .. ..|.|   .   .   |||| .  
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemg

ESMNCEAFTVTLISKDRLclSNeeqIIIHDFILEATQDDYVLEVRHFQCPKWP---NPDAPIS--STFELINVIKEEALT---RDGPTIVHDEYGAVSAG
.| .  .. | |.. . .  |.    .   . .  ...   . |. ||   |.   ..  | .  |  .|.. ..|   .     .| .||   |   .|
ksktfGglevklrtieei..sd...yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

MLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
.. .| .. ... .|  ||.|.. | .   || .   ..|| .||.|.   .
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1168-1413 6.1e-36 119.0 In-house 34-278 (281) alignment
Range on Protein: 1168-1413
Range on HMM: 34-278/281.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSR
 ..... |..||| | .|  . .|| ..|    | ||||||... ||   .|.|.|| |.|.. ..||.|.|......|||.  .          |||  
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

EESMNCEAFTVTLISKDrlclsNEEQIIIHDFILeATQDDYVLEVRHFQCPKWPNPDAPISsTFELIN----VIKEEALTRDGPTIVHDEYGAVSAGMLC
.....   .||. ...      .... | . | |  ...    ||....  .||.  .| . | ||..    | | .   .. | ..|   |   .|   
nselkygdvtvkstaee.....ekatyierkfkl.eresgetreveqlaytaWPdhGvPat.tkellefrkevlkltekktkaplvihCsaGvGrtGtyi

ALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
|| .| ...|.| . .|| .| . .   |  .   . ||.|.|||.|  .. 
alDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

0041856 (Phosphotyrosine protein) phosphatases II 1175-1411 9.2e-36 118.5 In-house 1-171 (182) alignment
Range on Protein: 1175-1411
Range on HMM: 1-171/182.0
NKEKNRNSSVVPSERARvglaplpgmkGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPdnqslaedEFVYWPSREesmncea
|..||| | ..| .. |          . |||||....|......||.||.||..|. ||.||..... ..||.|         |. |||...       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

ftvtliskdrlclsneeqiiihdfileatqDDYVLEVRHFQCPKWPNPDapISSTFELINVIKEealtRDGPTIVHDEYGAVSAGMLCALTTLSQQlene
                               ...........| .. ||  .......|. ..|    ..||..||  .|   .|.|.|.  . ..    
..............................erlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

nAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
  |..... |... .|||...  .||.|.. |.| |.
.gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1169-1409 1.9e-35 117.0 In-house 37-274 (515) alignment
Range on Protein: 1169-1409
Range on HMM: 37-274/515.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSlaEDEF---VYWPS
 ||.| | .|||   ..| ...|| |  .      ||.||||| ..   . .| .| |.. ...||||.....|   |.|. . .   .|      ||| 
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklke..gdkikcgkyWPd

-REESMNCEAFTVTLISkdrlcLSNEEQIIIHDfiLEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
   .|..   . | |.|     |.   . |.    |. ...| .  |  |.  .||.  .|   || . ||  .| .      | |.|   |.  .|...
kpgdsvkfGsikvelvs.....leactggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvi

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..     . .. ..||||.. . |   || .    ||| ||| |.| 
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle

PTPc_DSPc_SM00012 1018-1118 8.6e-35 114.5 In-house 2-105 (105) alignment
Range on Protein: 1018-1118
Range on HMM: 2-105/105.0
VIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPE--TGPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHD
| .||||.|||.||||.. ..|...|     .  .  ..||.||||||||||||....| .|||.... ..|... ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_PTPN3_pd Subfamily PTPN3 1164-1410 1.3e-34 114.4 In-house 30-274 (280) alignment
Range on Protein: 1164-1410
Range on HMM: 30-274/280.0
YVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIM----GYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-
 ...  |.|  | .|||   ..| . .|| |        ||||||.|.     .   .| .|.|| ||..|..|||.|.|......|||| ..       
glaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

EFVYWPSREESMNCEAFTVTLISKdrlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAV
   |||. |....   |.|.. ..     ........ ...|. .. .   .. ..|   ||. . | .|.  .|... ...   ... |..||   |  
ChqyWPetedeleygefsvkceke.....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGig

SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .|.| .| |  . .|....| . .. ...   |  .    .||.|. .|.| .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1175-1413 5.6e-34 112.4 In-house 20-266 (270) alignment
Range on Protein: 1175-1413
Range on HMM: 20-266/270.0
NKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYR-SNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREES-MN
.|. ||   ..|| ..|| |..|   . | |||| |. |.   ....| .. ||| |.|.||||||..... |||. . .    ..  .|||.. .. ..
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

CEAFTVTLISKDRlclSNEEQIIIHDFILEaTQDDYVlEVRHFQCPKWPNPDAPISST-----FELINVIKE-----EALTRDGPTIVHDEYGAVSAGML
.|. ... ..      ..||  |.    || .. .   .. ||.  .||.  .| ..       .|......     . | . .|..||.  |   .|.|
ledgkikvlalse...ekeegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 || .  . ||... ||| .. . .   |. .    |||.|.|||..  ...
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 869-1034 9.6e-34 111.6 In-house 28-182 (297) alignment
Range on Protein: 869-1034
Range on HMM: 28-182/297.0
SNHPENKHKNRYINILAYDHSRVKLRPLPgkdsKHSDYINANYVDGYNKAK--AYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.. .   .|||| .|||.| .||||.  .      .|||||.||   .. .   || .||||..| .|||....||. ..|||...| | || ||  |||
akrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

TENSE--EYGNIIVTLKSTKIHAcYTvrRFSIrnTKVKKGQKgnpkgrQNERVVIQYHYTQWPDMGVPEY
  . |  . |...|   |.     .   |  .  |...   .      ...|||    .  ||| |||  
svvqerlkagdvvveflsstsde.fd..rvil..telqliyr......sesrvvrhvqflswpdhGvpsd

subfamily_CG42327_pd Subfamily CG42327 849-1041 2.8e-33 109.9 In-house 8-186 (319) alignment
Range on Protein: 849-1041
Range on HMM: 8-186/319.0
SEDFEEVQRCTADMNitaehSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKhsDYINANYVDGYNKAK-AYIATQGPLKSTFEDFWRMIWEQNTGII
 |.|... .  |  .        .  | |.|.||..   ..|| |.  . .|..   |..|.|| ||..|.  |||.| .|...  ||||..|||.. .|
aeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkd..eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMITNLVEKGRRKCDQYWPTE----NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkKgqkgnpkgrQNERVVIQYHYtQWPDMGVPEYALPVLTF
| .|.| |.| ..| .|.||.    | . ||.| ||||  ...  | .  . ... .  |         .. | .  | | .|.. .||    .... 
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd..k.........eesrelthywy.kwleaevPaeeaaliam

0049772 (Phosphotyrosine protein) phosphatases II 1167-1415 6.6e-33 110.1 In-house 38-284 (314) alignment
Range on Protein: 1167-1415
Range on HMM: 38-284/314.0
CFSAQKECNKEKNRNSSVVPSErARVGLaPLPGMKGTDYINASYIMGYyrsNEFIITQHPLPHTTKDF----------WRMI--WDHNAQIIVM------
.  |....|..|||.  ..| .  ||.| |  ...|.|||||||. |.   . ||.||.||..|  ||          |||.  .|.|  .|||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LPD-----NQSLAEDEFVYWpsreesmnceaftvtliskdrlclsneeqiiihdfilEAT--QDDYVLEVRHFQCPKWPNPDAPI
               |..     |.  |.|   .                                      | .  ....  .. .. .  .| ..||.
adelsrLdaAlgKtpllildgngneptaadlellk.....................................eelydpelferlgikylripvpDgsapl

SSTF-ELINVIKEEalTRDGPTIVHDEYGAVSAG--MLCALTTLSQQlenenaVDVFQVAKMINLMRP-----GVFTDIEQYQFIYKAMLSLVSTKE
.. | |....|.|    ..||..||   |   .|  ...|.  . ..      |.. .. ... |.||     | .   |||.||..|.| ......
ledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 853-1112 7.6e-33 108.5 In-house 30-273 (301) alignment
Range on Protein: 853-1112
Range on HMM: 30-273/301.0
EEVQRCTAD-MNITAEHSNHPENkhKNRYINILAYDHSRVKLRplpgKDSKHSdYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMIT
|.|.  | |  .||  ..  |..  |.|| ..    .. |..     .| |    | ||...   ... .||||||||.| |||| |.   .   |||..
envnvttidkdhitesyaylpkd..khryptvPckPstavevi....vdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlg

NLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACyTVRRFSIRNTKVKkgqkgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAArmp
. |||  .||..| |.. ||.      ..| .. .      . | |. .|.     .  |. . | |. | |..|.| |||.    .  ..     .   
qkvekleekceeylpvkisekldigrfkikiknkeli.lnkkiskrtleve.....dstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks...

eTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFI
   |..||||||.||. ..|  . . .... . |...   |||.| .|   |||..|  ..
.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 869-1125 3e-32 106.7 In-house 30-275 (285) alignment
Range on Protein: 869-1125
Range on HMM: 30-275/285.0
SNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT
. .  |   ||| .. . . .|| |.       .  ||| |...    |   .||.|||||  |. |||.||....   ..|.  |.| |  ||  |.| 
tayeanpdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

ENSE--EYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGqKGNPKgrQNERVviqyHYTQWPDMGVPEYALPVLTFVRRSSAArMPETGPVLVHCSAGVG
.  |  ..|.  .||   |  |       ..  .. .     .|     ..|    .   |||   || | |.. . .       |.  |. ||||||||
klgevvkfgkyeitlteckeeaiagtilnaltvinteda.ssepl..ymnhv....qvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvg

RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|| |.. ||    .| ..  ...|  .. .|. |   ||.  |..|..  |.| ..|.  
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1155-1410 3.9e-32 106.2 In-house 27-278 (439) alignment
Range on Protein: 1155-1410
Range on HMM: 27-278/439.0
KLVTQCNAKYV-ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnq
. .   . .|  ..  | .| .. |||  .|.. . .|| |  .||.  . |||| || |||  . .| || |  .||.||||.......  |||| .  
ekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltn..

slAEDEFVYWPSREESMNCEaftvTLISKDRLCLSNEeqIIIHDFIL--EATQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEA-LTRDGPTI
    . . |||| .| .  .      .  ||     .   .|. | .  |  . .    | .|.   ||. . |       ...  |.        || .
..lvesykywpsdaevcygd....iavrvdrnielpn..yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvv

VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
||   |   .| . ||    .||  || ||.  . |..   |  .  .. || |||.|.|  
vhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

0036282 (Phosphotyrosine protein) phosphatases II 1202-1405 2.1e-31 104.4 In-house 1-164 (174) alignment
Range on Protein: 1202-1405
Range on HMM: 1-164/174.0
GTDYINASYIMGYYRSNEFIITQHPLPhttkdFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSreesmnceaftvtliskdrlclsneeqiiihdfil
|.||||||.. ..|.....|..|.||.     ||.|..... ...||| . . |  .  . |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

eaTQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTR--DGPTIVHDEYGAVSAGMLCALTTLSQQLEnENAVDVFQVAKMINLMRPGVFTDIE
  ...|.. .. ....  ||   .| .|... .  . |||| .  .||..||   |   .|.|.|.  . ..|. |..||.... ... |.|||...  .
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYQFIYK
||.|.|.
Qyrflyy

subfamily_egg_pd Subfamily egg 863-1124 3.7e-31 102.9 In-house 29-277 (307) alignment
Range on Protein: 863-1124
Range on HMM: 29-277/307.0
NITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKhsDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrRKCD
.|. ...   .|..| |   .   | |||||.   |. .   |.| ||.|.|      .| .| ||| | .|||||.....   |||.|  .|    .|.
eislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPTENSEEYGNIIVTLKSTKIHACYTV-RRFSIRNTKVkkgQ--KgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAarmpetgPVLVH
 |||  .|.    .  .|. . ..   .    | . . |.      .       .|   ...   ..  ..   . | ||  .|. |        ||.|.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgd.......deerflehwqgdvnnssdvysplrvlrklrnlsk.......pvvvq

CSAGVGRTGTYIVIDSMLQQIKDKST--VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL---EAILGKE
.  || ...| . |.  | ..    .    ||   . .| .|.. |..  .|.|..  .|     ..|  
dilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa

subfamily_PTPN1_pd Subfamily PTPN1 1159-1409 4.7e-31 102.6 In-house 16-269 (290) alignment
Range on Protein: 1159-1409
Range on HMM: 16-269/290.0
QCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLpdNQSLAE-
. .|. ... .|... |...||   | | . .|. |      . .|||||| .       ..|.|| |||.|.. ||.|.|..... .|||  |. . . 
rkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml..nkvveke

--DEFVYWPSREE--SMNCE--AFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPN---PDAPISSTFELINVIKEEALTRD-GPT
    . |||. ||  .. .|   ..|.|||..|     ... ... . ||  . .   |. ||   .||.   |..| .    | .| .  .|..| ||.
qikcaqywPqgeeekellledtklkvkliseer.....ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

IVHDEYGAVSAGMLCALTTLSQQLENE---NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..|   |   .| .| . |.  ..|..   ..||. .|   .  .| |.    .| .| | |.| 
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRN_pd Subfamily PTPRN 1146-1409 1.5e-30 100.9 In-house 27-290 (297) alignment
Range on Protein: 1146-1409
Range on HMM: 27-290/297.0
GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGY-YRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 |.||||... ... .|.   .  |..| | .|||...|.| . .|| |      . .|||||| |.    |.  .| || ||..|  |||.|.|.. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

IIVMLPDNQSLA-EDEFVYWPSREESMnCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEAL
.||.|   .    . .  |||   ...  ... | |.|.   |    .. ..  | |   | .    |  |    ||. ..| |.   .|.   .     
vivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwc....ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLEN-ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
 |  | .||   ||  .|. ...  . ..| .  . .|.    . .   |||.    .|..|...|.  
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1168-1409 4.1e-30 99.5 In-house 38-234 (392) alignment
Range on Protein: 1168-1409
Range on HMM: 38-234/392.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAedefvywpsre
 .|||| |..|||   ..| ..||| |  .  .  .||.||||| ..   . .| .| | . . .|||||....|.  |.|. . .              
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

esmnceaftvtliskdrlclsneeqiiihdfileatQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALT
                                    . | .  |  |.  .||. | |   || ...|. .| .      | |.|   |   .|.. .. 
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..  . ..   ||||..   |   || .    ||| ||| |.| 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_PTPN14_pd Subfamily PTPN14 1165-1410 6.3e-30 99.2 In-house 39-295 (300) alignment
Range on Protein: 1165-1410
Range on HMM: 39-295/300.0
VECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMkGTDYINASYIMGYYRS--NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN-QSLAEDEFV
 .. .|. . |.||||   |.| | .|| |.|      |.||||| |     .   ..|..| ||..| .|||.|.|... |.|||| .. ..  |  | 
allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPSREESMNCEAFTVTLISKDrlCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPIS-----STFELINVIKEEAL------TRDGPTIVH
|.|. |.. .   |    ...     .. ...| . . |.        .| |.|   ||. . |       |  | .. .....        .. | .||
yfPkleskkktvefgkfkvttk..fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

DEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
   |.  .|.|     | . ||... .|. .| ...   |  .   . ||.|.||...  
CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 872-1126 7.7e-30 98.6 In-house 41-282 (312) alignment
Range on Protein: 872-1126
Range on HMM: 41-282/312.0
PENKHKNRYINILAYDHSRVKLRplpGkDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWptenSE
   |  ||| ||  .|  |  |    | |     || ||.|    | . ...|||||..|   ||..     .  |.... .|| |  || .|     |.
lkfkdlnrypniqcwdrgrftla...g.d..enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi....sd

EYGniIVTLKSTKIHA--CYTVRRFSIRNTKV-KKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYAlpvLTFVRRSSAARMpETGPVLVHCSAGVGRTG
  |  .| |.  ....  |  .      . |. ..  |   |   .|  . .| .. ||| |.|.      |  |  || .  .  ||. ||||||||||
ivg..fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc...dtalrllsavkk.dkkpviahcsagvgrtg

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
| ..|.||.  ..     ||   .  .| .|   |..  ||..   ..|| .  |   
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

0051429 (Phosphotyrosine protein) phosphatases II 1202-1410 6e-29 96.9 In-house 3-224 (272) alignment
Range on Protein: 1202-1410
Range on HMM: 3-224/272.0
GTDYINASYIMGYYR---SNEFIITQHPLPHTTKDFWRMiWDHNAQIIVMLPDNQSLAEDE-FVYWP-----------SREESMNCEAFTVTLISKDRLC
 ..||||... ||.|    . .. ...|||.| .||||. ....   ||.| .   .. .  . |||           . .....  |..|||.|.  | 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LsneeqIIIHDFILEAT-QDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEealtrDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVD-------
      .|.  ..|. . . . ..||.|...  ||   .| ..  ||.... .     .|| .||   |    |...||  | .... |  ||       
d.....yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .... ...  .|||.. . |||.|.|.|.| |
yleeaveelraqrpgavqteeqylflyeallel

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1015-1161 9.7e-29 94.9 In-house 88-236 (440) alignment
Range on Protein: 1015-1161
Range on HMM: 88-236/440.0
ERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAA-RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIH
 |.. ||||  ||| |||..| ||| ...  . .      ||.|||||||.||||  |..||.|.. |    .... |.. .| .|  .||| ||| |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALLEAILGKETEVSSNQLHSYVNSILIPGV-GGKTRLEKQFKLVTQCN
.|.||..|  .| .  ...   |. |  |     |. |...|.  .. |
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskkn

0043147 (Phosphotyrosine protein) phosphatases II 1201-1404 4.1e-27 90.4 In-house 3-154 (172) alignment
Range on Protein: 1201-1404
Range on HMM: 3-154/172.0
KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNqslaedefvywpsreesmnceaftvtliskdrlclsneeqiiihdfil
.|.|||||||. .||  ..||.|| ||..|. |||||..... ..||.| .                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

EATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEE--ALTRDGPTIVHDEYGAVSAGMLCALTTLSqqleneNAVDVFQVAKMINLMRPGVFTDIE
. . .... .. ....  ||  ..|... .. .  . .|  || ..||..||  .|   .|.|.|.  .         ...... ...  .|||...  .
lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYQFIY
||.|.|
qyrfly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 913-1124 9.7e-27 88.2 In-house 84-292 (302) alignment
Range on Protein: 913-1124
Range on HMM: 84-292/302.0
DGYNKAKAYI-ATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE--YGNIIVTLKST--KIHACYTVRRFSIRNTKVKKGQKG
|| .| .        | ||| | .| .| . |..|.| ....||.. .|| .|. ..  .|  .|.  |. .|   ...     . | . . ..|  .| 
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

NpkgRQNERVVIqYHYTQWPDMGVPEYALPVLTFVRRSSAARMpetgPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE
.   ...  | |  ... ||| | |. | . |  ..   . .      |||||||||||||| . |   .|  . | . ..|  .. .|. |   ||.|.
k...kvkktvdi.lafsawpdhGapkeaytaldilkfcesykk....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

QYIFIHDALLEAILGKE
| |..   .  ... |.
qliylllcvtkglmeka

0046846 (Phosphotyrosine protein) phosphatases II 1201-1410 2e-26 88.2 In-house 10-172 (176) alignment
Range on Protein: 1201-1410
Range on HMM: 10-172/176.0
KGTDYINASYIMGYYrsneFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCeaftvtliskdrlclsneeqiiihdfil
 . |||||..|.|..    .|.||.|||.|. ||..|..... ...|.| . . |.   . ......|....                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

eatqddyvlevrHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTtlsqQLENENAVDVFQVAKMINLMRP-GVFTDIEQ
            ....  ||  ..| .. .. .  . .|||...||..||   |   .|.|.|.      || |. ..|... ...  .|| |...  ||
............qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YQFIYKAMLSL
|.|.|...| |
yrflyefelll

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1147-1407 4.2e-26 86.5 In-house 5-255 (267) alignment
Range on Protein: 1147-1407
Range on HMM: 5-255/267.0
KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.. .||.|.|...   .   .     | |.|.||   ..| . .|| |      |  .||||||. ||.. | ||.|| ||  |  ||. .| |..  .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLpdNQSLAEDEFVYWPSR-EESMNCEAFTVTLiSKDRlcLSNEEQIIIHDFILEatqDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRD-
|.|   ..  ..   .|| .  .. . . .||   | ..    |. |||  .. ..   ..   .|  .   ||            |. .. .. |    
vll..tkvftdnirlfwPPkmgqakkyqdltveh.slek..eendyqiitlelkfk...nesahnvtlyyykkwnintnnkpylkplfgilaknqlengn

GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
 | .|. . |   .| .  . .  ... .|. .|.|.  . |   |.|.    |.| .|.. .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell

0048076 (Phosphotyrosine protein) phosphatases II 979-1117 7e-26 86.0 In-house 24-140 (145) alignment
Range on Protein: 979-1117
Range on HMM: 24-140/145.0
TLKSTKIHACYTVrrfsirntkvkkgqkgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPEtGPVLVHCSAGVGRTGTYIVIDSMLQ
.||. .| . ...                 .  .  || .|||.|. |||.|||. .  .|.|..   .|.  . ||||||||||||||||..... ||.
llkdlgittvlnl................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll

qikdkSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
       |..   |...|.|| . |....|..|.....|
.....lgvsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 1008-1114 9.4e-25 82.4 In-house 48-139 (144) alignment
Range on Protein: 1008-1114
Range on HMM: 48-139/144.0
NpkgrqnervVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMpETGPVLVHCSAGVGRTGTYIVIDSMLqqikdKSTVNVLGFLKHIRTQRNYLVQTEE
.         .|||... |||.|||...  .|.|..   .|.  | ||||||||||||||||..... |.     |  ...   |...|..| . |....
e.........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

QYIFIHD
|..|...
qlrfLle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1170-1408 2.1e-24 81.0 In-house 2-237 (239) alignment
Range on Protein: 1170-1408
Range on HMM: 2-237/239.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSN-EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPSRe
|.|  || ||| . .|  ...|| |  |     .|||||||.  |  |   .| ||  .  .. |||||.|.    .||||        .  . |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ESMNCEaFTVTLISKDRLClsneeQIIIHDFILEA---TQDDYVLEvrhFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
 |  |. . |||   . ..     . ||. |..     |.. || .   ..   ||.   |  .|  . |   | ...|    | ..|   |   .| . 
tskycn.lrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
 . .. .| .....||.|.  | |   || .    ||| ||. |.|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1170-1408 2.2e-24 80.9 In-house 3-238 (239) alignment
Range on Protein: 1170-1408
Range on HMM: 3-238/239.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSN-EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPSRe
|.|  || ||| . .|  ...|| |  |     .|||||||.  |  |   .| ||  .  .. |||||.|.    .||||        .  . |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ESMNCEaFTVTLISKDRLClsneeQIIIHDFILEA---TQDDYVLEvrhFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
 |  |. . |||   . ..     . ||. |..     |.. || .   ..   ||.   |  .|  . |   | ...|    | ..|   |   .| . 
tskycn.lrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
 . .. .| .....||.|.  | |   || .    ||| ||. |.|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1175-1408 5.1e-24 79.8 In-house 3-236 (237) alignment
Range on Protein: 1175-1408
Range on HMM: 3-236/237.0
NKEKNRNSSVVPSERARVGLAPlPGmKGTDYINASYIMGYYRS-NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMNC
|| ||| ...|  . .|| |   .|  |.|||||.|. |.  . ...| .| ||  . .|||.|.|. .  .||||       |     |||| ..    
nkiknrygnivaydhsrvvlkg.ag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

EAFTVTLISKDRLCLSNEEQIIIHdfiLEATQDdYVLEVRHFQCPKWPNPDAPISSTFEL---INVIKEEAL-TRDGPTIVHDEYGAVSAGMLCALTTLS
  .||.|  |. ..      ...     . |.   |  .  .|   ||.   |  ..  |    |.|..    .. || |.|   |   .|..  . .. 
gvltvslkkkeefsdytvrsllls...krltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.| .... ||...  . |.  || .    .|| ||....|
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 918-1113 3.5e-23 76.8 In-house 4-197 (199) alignment
Range on Protein: 918-1113
Range on HMM: 4-197/199.0
AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS--EEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkGNPkgrqNE
 . ||||| ||. |. |||.|.||  .| |||. .   .       |||| .|   .||.. || |.   .. ||.  . . |          |      
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.....app....st

RVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR---MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD--KSTVNVLGFLKHIRTQRNYLVQTEEQYI
| . .| .| | .   |. || |   |     ..        ||.|||| | | || .. .|  ..  ..   | |...   | .|  |  .. . ..| 
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FIH
||.
fiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 919-1113 3.9e-23 76.6 In-house 4-196 (198) alignment
Range on Protein: 919-1113
Range on HMM: 4-196/198.0
KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS--EEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkGNPkgrqNER
. ||||| ||. |. |||.|.||  .| |||. .   .       |||| .|   .||.. || |.   .. ||.  . . |          |      |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.....app....str

VVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR---MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD--KSTVNVLGFLKHIRTQRNYLVQTEEQYIF
 . .| .| | .   |. || |   |     ..        ||.|||| | | || .. .|  ..  ..   | |...   | .|  |  .. . ..| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IH
|.
iy

0044763 (Phosphotyrosine protein) phosphatases II 1186-1411 4.6e-23 77.2 In-house 1-171 (178) alignment
Range on Protein: 1186-1411
Range on HMM: 1-171/178.0
PSERARVGLAPLPGMKGTDYINASYIMGYyrsneFIITQHPLphttKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSREEsmnceaftvtliskdr
| .| || | .|.|. ..||||||.|...     ......|      |......... . ||.| ... |  .... |||....                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

lclsneeqiiihdfileatqddyvLEVRHFQCPKWPNPDapISSTFELINVIKEEAL-TRDGPTIVHDEYGAVSAGMLCALTTLSQQlenenAVDVFQVA
                        ....|. .| ...||  ... |. .  . |||| ...||..||  .|   .|.|.|.  . ..      ...... 
........................iqylhipipDhgvpd..llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

KMINLMRPgVFTDIEQYQFIYKAMLSLV
...  .|| ...  .|....|.  | | 
elvrerRp.ivpnpgqlrqLyefelrll

subfamily_egg_pd Subfamily egg 1167-1409 9.8e-23 75.3 In-house 32-268 (307) alignment
Range on Protein: 1167-1409
Range on HMM: 32-268/307.0
CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFvYWPSR
   | .. |.|| |.  |   . .|| |    |.   |.| | .. |    ||||..| ||  | .|||||..  . | ||||  ..   . |. |||  
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkesercey.ywpka

E-ESMNC--EAFTVTLISKDRlclSNEEQIIIHDFILeATQDDYVLEVRHFQCpKWPNpDAPISSTFELINVIKEealtRDGPTIVHDEYGAVSAGMLCA
| .|.     .. .. .  |.     .    .  . |    ||  . . |.|   . |  . . | ....  ...       |..|.|  |   |. | |
esdslvtvpGslrienlkvds...kadplfrvtklkl.vGgddeerflehwqg.dvnn.ssdvysplrvlrklrn....lskpvvvqdilGvskaatlva

LTT-LSQQLEN-ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
. . | . |        | .  ... | |.     . .| |.|. .| 
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 873-1014 2.1e-22 73.9 In-house 47-198 (349) alignment
Range on Protein: 873-1014
Range on HMM: 47-198/349.0
ENKHKNRYINILAYDHSRVKLR--PLPGKDSKHS----------DYINANYVD--GYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGR
|   |||| .|| |.||||||.  . . | .|.|          |||||||.    ..  | ||||| || || .||...|  ..  ... ...  |.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

RKCDQYWpteNSEEYGNIIVTLKSTKIHACyTVRRFSIRNTKVKKGQKGNPKGRQN
.|||.||   .  .| || | |. .  ...  |.  | |  .||. .. |   ..|
ekcdiyw...qelsysnitvklqnsslyia.nvqGnslrvstvkdtdndndnnkkn

0049260 (Phosphotyrosine protein) phosphatases II 1210-1405 3.2e-22 74.3 In-house 1-144 (152) alignment
Range on Protein: 1210-1405
Range on HMM: 1-144/152.0
YIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-EFVYWpsreesmnceaftvtliskdrlclsneeqiiihdfileatqddyv
.| ||....|||.||.|.|.|..|||||........|||| . . |... .  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

levRHFQCPKWPNPDAPISSTFELINVIKEE-ALTRDGPTIVHDEYGAVSAGMLCALTTLSqqleneNAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
   .....|   ..  ..|  .. .. . |. || ..||..||  .|   .|.|.|.  .       . |..... ...  .|||...  .|..|.|.
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 845-1126 4.9e-22 72.7 In-house 25-291 (302) alignment
Range on Protein: 845-1126
Range on HMM: 25-291/302.0
QHGFSEDFEEVQRCTADMNItaeHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTF---EDFWRMIWE
.    ..|....   .|..     . . .| .||.  .. ..|. .|||        .  .|.||  |.  .  .  | .| | ...    |.||||...
taevkkefkkidtmkvdlek...Ckafkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QNTGIIVMITNLVEKGRrKCDQYWP--TENSEEYGNIIVTLKSTKIHACYTvRRFSIRNTkvkkgqkgnPKGRQNERVVIQYHYTQWPDMGVPEYALPVL
..   .|..    |  .   ....|  ... .|||.. |  .  .     .  |..|            |.|  |  ..  |. |.|..  ||.    . 
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvl.........PegcsnsvlanvyvltnWkqkkvpvkyaeli

TFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. .    |  .. . ....    |.|| |. ..    ........ .|.   .| ||.||   |.. .||.... |||  |. | |.
ktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk

0051082 (Phosphotyrosine protein) phosphatases II 1203-1407 5.3e-22 73.5 In-house 3-149 (151) alignment
Range on Protein: 1203-1407
Range on HMM: 3-149/151.0
TDYINASYIMGYyrsneFIITQHPLPhttkDFWRMIWDHNAQIIVMLPDNQSLAeDEFVYWPSREesmnceaftvtliskdrlclsneeqiiihdfilea
.||||.||. |.     ......||.    ||........ . ||.| . .  .  .  |.|. .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

tqddyvLEVRHFQCPKWPNPDAPI--SSTFELINVIKEealTRDGPTIVHDEYGAVSAGMLCALTTLSQQlenenaVDVFQVAKMINLMRPGVFTDIEQY
      .||.|.... ||.|. |.   .  |..... .   ...||..||   |    |.|.||  . ..      |..... ... |.||||..  .|.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

QFIYKAM
.|...|.
lfqlfal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1150-1410 5.7e-22 72.7 In-house 29-289 (310) alignment
Range on Protein: 1150-1410
Range on HMM: 29-289/310.0
LEKQFKLV-TQCNAkyVECFSAQKEcNKEKNRNSSVVPSERARVGLApLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVM
| ||.. . .. ..     . | |. .  ||| | ||  . .|| |  .   .  ||| | |.   |  . || .| || ||  ||||||..  |. |..
lvkqyrkldakqds..sltyeaykk.ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesill

LPDNQSLAEDE-FVYWPSR--EESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVR--HFQCPKWPNPDAPISSTFELINviKEEALTR
|             ||||    |.  |   |    | . . . |    .. | .    |   . |.|    . |.||.   |      . .  .  |  |
lckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq..rllaqvr

DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 || .||   |    ....||    ..|.. . ||. .|   .   |  .     || .| . .. .
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

subfamily_eak_pd Subfamily eak 865-1139 7.3e-22 72.2 In-house 43-326 (332) alignment
Range on Protein: 865-1139
Range on HMM: 43-326/332.0
TAEHSNHPENKHKNrYINILAYDHSRVKLRPlpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQY
. . ..  |. ..|  ..|. ||.  |.| .       .  ||||  ..  .  . || |  . ..    ||.|. ||..  ||.. . ||..  | |.|
sisetarleavnrn.vvkivpydrylvrlts...sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPTEN--SEEYGNIIVTLKSTKIHACYTVRRFSIRNTK-VKKGQKGNPKGRQNERVVIQY----HYTQWPDMGVPEYALPVLTFVRrSSAARM---PETG
.| .     ..| . |. |.   .. . .| . ..     .. .. .  |  .  . .       .    ..||.  . .  . .. |   .    | . 
fpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksalls.stlkkyihtppsf

PVLVHCSAGVGRTGTYIVIDSMLQQIKDKST--VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS--NQLHSYVNSI
  .. .. |  |.|...||| ... | .| .    |  ..  ....|.. | .. |. ||....|. .| .. ..    ..| .| .|.
apiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleayaesv

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 850-1123 3.2e-21 70.2 In-house 26-282 (303) alignment
Range on Protein: 850-1123
Range on HMM: 26-282/303.0
EDFEEVQRCTaDMNITAEHsnHPENKHKNRYINILAYDHSRVKLrplpgkdsKHSDYINANYVDgYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVM
..||.|       ... ..    .| .|||.....  |||.|||          | || |.|..  .  |  | || ||  |  |||.|| ||.   ...
nefekvvsyl.ppsvsknq..fvknmdknrfvdvicldhskvkl........sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvll

ITNLVEKGRRKCDQYWPTENSeeYGNiiVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGrqnerVVIQYHYTQWPDMGVPEYALPVL--TFVR-RSS
.    |  .   |  .| ..   . .     .| ..     |      . ||    .|. |       .  .|| .||   .|  . | .     . .| 
lltdseydklggdsvfprnqd..flk..feersirvgefkrvelgdgwvlkvlsvsngdyks.....flhvhhykawphnsipsdgspkfvkqiwqlqsv

AARMPETGPVLVHCSAGVGRTGTYIVIDSM-LQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK
  .  .. | .    .|.||.||. ....  |   .........  |. .|  | . ||   |. ...  | | .|..
lrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn

subfamily_ptpA1_pd Subfamily ptpA1 1151-1266 4.4e-21 70.1 In-house 24-138 (418) alignment
Range on Protein: 1151-1266
Range on HMM: 24-138/418.0
EKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRsNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP
...|.|. .      |    .|. |  ||| . ..| ...|| |  .   .|.||||| || | |  ..|| || ||| |  |||||.|.  ..||||| 
keefrlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmls

DNQSLA-EDEFVYWPSR
 .   .      ||| .
resencrikcdrywpeq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 884-1120 9.4e-21 69.0 In-house 39-221 (255) alignment
Range on Protein: 884-1120
Range on HMM: 39-221/255.0
LaydhsrvklrplpgkdskhsdyinanyvdgynkakayiatqgplksTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKST
|                                              | . |...|  ..|  .||.... |.|. ||..|.|.|  |      |.. .|
l..............................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvttt

KIHACYTVRRFSIRNTKvkkgqkGNpkgRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpetgPVLVHCSAGVGRTGTYIVIDSMLQ----Q
|  |   .|   |  |       |.   ... . |  |.|. |..   || |  .|  ..    ..     .|.||||.|.||. ........ |    .
kssadvvlrtleitstl......ge...kkkthtvkhysykGWieknaPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirs

IKDKSTVNV--LGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..  .||..  | .|...| .|.  ..|  |  |    .|. .
ldttetveldylslleelrskrkraihtPlqlafsilmvldlv

PTPc_DSPc_SM00012 1311-1408 2.1e-20 68.3 In-house 2-104 (105) alignment
Range on Protein: 1311-1408
Range on HMM: 2-104/105.0
VRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
|.|.....||.  .|   .| .||.. .|..   ..  .|..||.  |.  .|...|| .| ||||.| . ||.||. |..  .|||...  |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AML
|.|
all

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1219-1405 2.4e-20 67.5 In-house 5-197 (198) alignment
Range on Protein: 1219-1405
Range on HMM: 5-197/198.0
EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKdRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCP
 .| ||||| .|  |||.|.|.  .  |||. |.|   | |  .|||. | .   .  .... .|  ..   .  |    .  ..|      |. |.|  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttk.tittkpdytitaliltnnttappstreishyqft

KWPNPDAPISSTFELI-----NVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE--NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
 | .  .|  . |  .     .| |     .| | |||   |   .|.. ||    .  |  .   ||.|.||| .   | |. . ...|.|||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1219-1405 2.5e-20 67.5 In-house 6-198 (199) alignment
Range on Protein: 1219-1405
Range on HMM: 6-198/199.0
EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKdRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCP
 .| ||||| .|  |||.|.|.  .  |||. |.|   | |  .|||. | .   .  .... .|  ..   .  |    .  ..|      |. |.|  
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttk.tittkpdytitaliltnnttappstreishyqft

KWPNPDAPISSTFELI-----NVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE--NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
 | .  .|  . |  .     .| |     .| | |||   |   .|.. ||    .  |  .   ||.|.||| .   | |. . ...|.|||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1147-1410 2.9e-20 67.5 In-house 15-276 (307) alignment
Range on Protein: 1147-1410
Range on HMM: 15-276/307.0
KTRLEKQFKLVTQCNAK--YVECFSAqkecNKEKNRNSSVVPSERARVGLApLPGMkGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 ..|  .|. ... . .   ||.|||    | .||| . |   ...|. .  ..|.  .||| | |.    . . || .| ||  |  .|| |. ... .
vqalvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekve

IIVMLPDNQSLAEDE-FVYWPSREESMNC---EAFTVTLISKDRLCLSNEEQIIiHDFILEATQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKEEA
 ..|| .   ||.     |||  |   .    .. |...       |. .|..|     |.    .    ..|.|  .||.  .|    .  ||...   
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgvpqi.nltainlleavr

lTRDGPTIVHDEYGAVSAGMLCALTTLSQQ-LENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
     | .||   |   .| . |.. . .. .. .|  |. .. . .   |.    .  || .... .|. 
.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1167-1410 4.4e-20 66.5 In-house 29-268 (281) alignment
Range on Protein: 1167-1410
Range on HMM: 29-268/281.0
CFSAQKECNKEKNRNSSVVPSERARVGLAP-LPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWP
|   ..  |..||| . .   . .|| |   .|  . |||| | ||   .    .|.|| |   |  |||||||. |.  |||| .      ..   |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

sREeSMNCEAFtvtliskDRLCLSNEEQIIIHDFILEATQDDYVLE---VRHFQCPKWPNPDAPISSTFelINVIKEEALTRDGPTIVHDEYGAVSAGML
 |. .  |  |       |.| .| |.  . . ..    .  |  |   . |.   .||. . | ||    .  |  .  .|  | ..|   |   .| |
.rn.ahcclqf.......dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev..mlkilrkirarstppvihcsagvgrsgtl

CALTTLSQQLENENA-VDVFQVAKMINL-MRPGVFTDIEQYQFIYKAMLSL
 |.    | . .  .  |. |.   . .  |      ..|| .|.| .| .
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_CG42327_pd Subfamily CG42327 1174-1328 2.1e-18 61.1 In-house 27-180 (319) alignment
Range on Protein: 1174-1328
Range on HMM: 27-180/319.0
CNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRS-NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSREESMN
  |.|.|   |||   .|| |   .  . . |..|||. ||  . | .| .| .|  .. ||||..|. ....|| | | . |  .    |.|..|   |
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

CEAFTVTLISK-DRlclSNEEQIIIHDFILEATQDDYVLEVRHFQCpKWPNPDAPISS
 ...   |..  .|     ... .|  ..|   ...   |. |.   ||.. . | . 
tslyGdilvtlkgr...evkdryaistlllkrvdkeesrelthywy.kwleaevPaee

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1172-1295 5e-18 59.6 In-house 93-211 (244) alignment
Range on Protein: 1172-1295
Range on HMM: 93-211/244.0
KECNKEKNRNSSVVPSERARVGLAplPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnqslAEDEFVYWPSREES-M
.  |  |||... .| .  || |.   |  |  |||||..    |. |.|.|||||  |. |||.|. .   ...|.|       |.|  |||  |    
npnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs....veeedeywpdseplew

NCEAFTVTLISKDRLCLSNEEQIII
  |  ||||  .| .      .. |
yeeditvtltdrdefknikasnlei

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1161-1410 6.5e-18 59.4 In-house 42-282 (290) alignment
Range on Protein: 1161-1410
Range on HMM: 42-282/290.0
NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplPGMKGtDYINASYIMGYyrSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-E
 ..|.|    .|. . .|||   ||  ...|| |    | .| ||. | |. |      ||.|| .|  |. |.|||. ....  |||| .         
pvqylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakc

FVYWPSRE-ESMNCEAFTVTLISKDrlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPIsSTFELINVIKEeALTRDGPTIVHDEYGAVSA
  |.| .| | .   ..||.   .|    .....|| . . .   ..     ..|..   ||.   .  ||. |. ...    .  || .||   |   .
eqyypekeGevltfGeitvlcseed....dkdaniikktlsvrdkdsGkehklkhlkikswpdksval.stlallrtlri.lrkasGpvvvhcsaGiGrt

GMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
| . |. .  | | .  ..|. .. . .   | .      ||  . ...| |
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_hpo-7_pd Subfamily hpo-7 907-1117 8.5e-18 59.2 In-house 42-224 (263) alignment
Range on Protein: 907-1117
Range on HMM: 42-224/263.0
InanyvdgynkakayiatqgpLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHAcytvrrFSIRNTKVKKGQK
.                    |  | . |...|  ..|  .||...  |.|. ||..|.|.|  |      |.. .||.          .  |..   . 
l....................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs......dvllktlellstl

GNpKgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpetgPVLVHCSAGVGRTGTYIVIDSMLQ----QIKDKSTVNV--LGFLKHIRTQRN
|. |  .. . | .| |. |..   || |  .|  ..     .     .. ||||.|.||.  . |.... |    ...  |||..  | .|...| .|.
ge.K..kkthtvkhysykgWiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrk

YLVQTEEQYIFIHDALL
  ..|  |  |    .|
raihtPmqLafsilmvL

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 859-1110 1.5e-17 58.1 In-house 19-292 (332) alignment
Range on Protein: 859-1110
Range on HMM: 19-292/332.0
TADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskhsDYINANYVDGYNKAKAYIATQGPLKSTFE-DFWRMIWEQNTGIIVMITNLVEKG
|. |     . .  .|   ||   . ..|||||.| |  |||    |. ||..||||.|  ||| .| |..   |  ||||. |..  .|... .. || 
tsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq

RRKC-----DQYWPTENSEEYGNIIVTLKSTKIHACYTV----------RRFSIR------NTKVKKGQKGNPKGRQNERVVIqYHYTQWPDM-GVPEYA
.||.     |. .      |.|   .     | . |  .            .||.      .|..|  .    . .|. . |.  |. .| |   .||| 
krkapydisdrgfeksflhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadasklpeym

LPVLTFVR----RSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYI
| . . ..    |||       ||... |..|| .   .  || .. .| ..  | .   .  |. ||   ..|   | 
ldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpys

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1045-1120 3.8e-17 57.1 In-house 220-295 (297) alignment
Range on Protein: 1045-1120
Range on HMM: 220-295/297.0
SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
|  | ||   ..||||||||||.|  .  | .|.... |   .|  .|...| ||  |||| ||. ...|| |. .
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1206-1390 8.5e-17 55.8 In-house 78-260 (301) alignment
Range on Protein: 1206-1390
Range on HMM: 78-260/301.0
INASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-EFVYWPSR-EESMNCEAFTVTLISKDRLClsnEEQIIIHDFILEAT
| | .|    ... ||.|| ||. |..||| |.  .. . ||||  .    |.    | |.. .|... . |.... .|. .    ...|.   . .| .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelil...nkkiskrtleveds

QDD-YVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEaltrDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMR
 ..     | |.|  .|.. . | |   .|.|....|.     . | .||   |   .  . .   |....|... ... .  | ..  |
tgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 888-1117 1.3e-16 55.6 In-house 32-256 (290) alignment
Range on Protein: 888-1117
Range on HMM: 32-256/290.0
HSRVKLRPLpgKDSKHSDYINANYVDgYNKAKAYIATQGPLK-------STFEDFWRMIWEQNTGIIVMITNLVEKGRR----KCDQYWPTENSEEygni
..|| |.    .    .||| ||.|  . .  . |.|| |..       || |.|| |. . .   .||. .  || .      | .| |..  ||    
atrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee....

iVTLKSTKIHACYTV--RRFSIRNTKVKKGQkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSaarmPETGPVLVHCSAGVGRTGTYIVID
 ...|  ... .  .    . .|.  || ..       ..|  |  . . .| .. |.|  . .|. ..        .. ||.|||  |. |  .   |.
.lkfkgltvkCkskekeddvetRelvvkfdd.......eeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaii

SMLQQIK-DKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
   | |   .. |..   || .| ||. ........ |.  ...
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1166-1325 1.9e-16 54.8 In-house 23-180 (297) alignment
Range on Protein: 1166-1325
Range on HMM: 23-180/297.0
ECFSAQKE-CNKEKNRNSSVVPSERARVGLapLPGMKGTDYINASYIMGYYRS--NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FV
| ||. |      |||   ..  . .|| |  | .. ..||||| |..         .|..| ||  | .|||....... ..|||.   |    |  . 
esfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPSR-EESMNCEAFTVTLISKDRlclSNEEQIIIHDFILEATqdDYVLEVRHFQCPKWPNPDAP
||||  .| ...  . |  .|.      . ...|. .. |     .    ||| |   ||.   |
ywpsvvqerlkagdvvveflssts...defdrviltelqliyr..sesrvvrhvqflswpdhGvp

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1057-1121 3.7e-16 53.3 In-house 2-67 (69) alignment
Range on Protein: 1057-1121
Range on HMM: 2-67/69.0
LVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI-L
.||||.| |||||.| |   . .|| .  |...  ....|  |  .|  | .|||||||| ||. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 826-926 6.6e-16 52.3 In-house 3-95 (95) alignment
Range on Protein: 826-926
Range on HMM: 3-95/95.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQrCTADMNITAEHSNhpENKHKNRYINILAYDHSRVKLRplpgkDSKHSDYINANYVDGYNKAKAYIATQ
  | |  |  |. |..|| .. | ..|  ..  |.  . |.  |.   |  |||..||. || .|| |        . |||||| .|||| . ..|||.|
kpihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsse..anipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaq

G
|
g

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1168-1414 7.1e-16 52.8 In-house 40-290 (305) alignment
Range on Protein: 1168-1414
Range on HMM: 40-290/305.0
FSAQKE-CNKEKNRNSSVVPSERARVGLaplPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPS
. | ||  ...|||   |   .. || |    |    .|| | |.     .. || || || .|  ||| | .... . | || . .   |.  . |..|
mkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfas

REES-MNC----EAFTVTLISKDRLCLSNEEQIIIH--DFILEATQdDYVLEVRHFQCPKWPNPDAPISStFELINVIkEEALTRDGPTIVHDEYGAVSA
...  ..     .  .| . |  .| . .. .  .    ...| .    .. | |.    ||.   | .    ..... |.| .  ||..||   |   .
kdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaad.lailell.ekarpskgpivvhcsagigrt

GMLCALTTLSQQLENENAVDVF-QVAKMINLMR-PGVFTDiEQYQFIYKAMLSLVSTK
| .  |  . .|| . . ..   .. . |   |   . || .|| |... .|  .  |
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtd.aqylfvhqvilnyfrkk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1058-1122 1.3e-15 51.5 In-house 2-67 (69) alignment
Range on Protein: 1058-1122
Range on HMM: 2-67/69.0
VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI-LG
||||.| |||||.| |   . .|| .  |...  ....|  |  .|  |..|.|||||| ||. ||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 867-980 1.4e-14 48.3 In-house 89-195 (244) alignment
Range on Protein: 867-980
Range on HMM: 89-195/244.0
EHSNHPENKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrkcDQYWP
. .  |.| .|||    | .| .|| |     | |    |||| .|    ..  || || ||  |  |||.|. |.   ..|..  . |.     |.|||
kdafnpnnswknregaglpfdfnrvpl....skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp

TENSEEY-G-NIIVTL
  .  |.   .| |||
dseplewyeeditvtl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1171-1411 2.8e-14 47.4 In-house 49-289 (305) alignment
Range on Protein: 1171-1411
Range on HMM: 49-289/305.0
Q--KECNKEKNRNSSVVPSERARVGLAPLPgmkGTDYINASYIMG-YYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSR
.   . .. ||| . |   ... | |.  .    .||| | |.       . || .| || .|  .|| |. ... . ||||     |       |||  
nqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

-EESMNCEAFTV-TLISKDRlCLSNEEQIIIHDFILEAtQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEALtrdgPTIVHDEYGAVSAGMLC
  | ..  .  |   .|  .  .  . .| |  . |     |  . |||.|  .||.   |    ...||.  |.   .    | .||   |   .| . 
qgeklelksgivvenvsgsk.pmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtiv

ALTTL-SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|.  .  .  || ..  . .. | .   |     .  || ||.. ||  .
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_CG42327_pd Subfamily CG42327 1049-1116 4.7e-14 46.8 In-house 243-311 (319) alignment
Range on Protein: 1049-1116
Range on HMM: 243-311/319.0
RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
.  . ||. |||| ||||||. |  |  ......   .|..   . ..| .|   |.| ||| ||.  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1148-1414 5.8e-14 46.2 In-house 26-288 (302) alignment
Range on Protein: 1148-1414
Range on HMM: 26-288/302.0
TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGlaplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTT---KDFWRMIWDHNAQ
....|.|| . .  ..  .| . .|. .| .. .  .. |.. ...      ..  .|.||| .     ... |..| |   ..    .||||..... .
aevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IIVMLPDNQSLAE--DEfvYWPSREESMncEAFTVTLISKDRlCLSNEEQIiiHDFILEATQDD----YVLEVRHfqCPKWPNPDAPISSTFELINVIK-
 .|.|  .. | .  .|  ..| . ..   . .    . . .   . ||.   . ...|   ..     . .| .  .  |..   |.. .    .. | 
svvilvgeeelkktlse..lfpkksgdy..keygkmfvNnrk.Vekaeeek..tryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakv

-EEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
 ..    | .|..  ..||  ||.. .|..  ..|...... . ...| |   || .   ..|| ..| |.| .. .|
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1177-1282 1.1e-13 45.6 In-house 49-165 (350) alignment
Range on Protein: 1177-1282
Range on HMM: 49-165/350.0
EKNRNSSVVPSERARVGLA--PL------PGMKGTDYINASYIMGY----YRSNEF--IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFV
 ||| . ..| |..|| |   .         ... |||||.|.           .|  | || ||| | .||...|   . ..|..| ... |  |    
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSreesMNCEAFTVTLISK
||.      . . .|| | ||
YWqe....gsydditvklask

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1200-1320 8.7e-13 42.7 In-house 10-122 (130) alignment
Range on Protein: 1200-1320
Range on HMM: 10-122/130.0
MKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnqslAEDEFVYWPSREESM-NCEAFTVTLISKDRLCLSNEEQIIIHDF
..| .|||||..    |..|.. |||||  |. |||.|. .    ..|.|       |.|  |||  |      |  .|||  .|     . ... |.. 
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs....veeedeywpdsePlewyeediivtltdrdefknikasnleiesd

ILEATQDdyvleVRHFQCPKWP
. |. |      .  ||  .||
lneshqa.....ltmfqisnwp

fn3 Fibronectin type III domain 348-429 9.4e-13 41.3 Pfam-A 1-79 (85) alignment
Range on Protein: 348-429
Range on HMM: 1-79/85.0
SPPIHMKVQPLNQTALQVSWSQPEtIYHPPIMNYMISYsWTKNEDEKEKTFTKDSDKDlKATISHVSPDSLYLFRVQAVCRN
|.|  ..| . . | |..||| |.   . || .| . | ..|.. |..|.|| .....  .|...  |.. | |||||| ..
saPenlsvsevtstsltlsWsppk.dgggpitgYevey.rekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1166-1408 1e-12 42.6 In-house 26-267 (285) alignment
Range on Protein: 1166-1408
Range on HMM: 26-267/285.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYI-MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN-QSLAEDEFVYW
.|  .  |.| . || . |   | .|| |      .  ||| ||.. |     . .| || ||| |  |||.||.. .   ..||    .   |   .|.
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PSR-EESMNCEAFTVTLISKDRLCLSNeeqIIIHDFILEATQDD--YVLEVRHFQCPKWPNPDAPISS--TFELINVIKEeALTRDGPTIVHDEYGAVSA
| .  | ..   . .||      ...     |.  . .  |.|     | . | | | ||.  ||  .    || . .|.    .. |  ||   |   .
peklgevvkfgkyeitlteckeeaiag...tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrt

GMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
  .  .   . .. ..  ...... . .  ||        |. |.|  ..
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1166-1262 1.1e-11 38.9 In-house 28-130 (347) alignment
Range on Protein: 1166-1262
Range on HMM: 28-130/347.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG-----TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD-HNAQIIVMLPDNQSLAEDE
.. |.. | . .|||   |   . .|| |.|    ..       |||||.|     |.|.|.||.|||.| .|||.|.   . .|.. ..   .  | .|
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

FVY
|  
fan

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 913-991 1.6e-11 38.2 In-house 230-306 (440) alignment
Range on Protein: 913-991
Range on HMM: 230-306/440.0
DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrKCDQYWPTE-NSEEYGNIIVTLKSTKIHACYTV
.|| | .|.|||| || ||  ||||.. . .   |.|. .| .|    |  ||| .  |  .| . |  | ..      |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1212-1320 4.6e-11 36.7 In-house 230-329 (440) alignment
Range on Protein: 1212-1320
Range on HMM: 230-329/440.0
MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLpdNQSLAEDEFVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHdfILEATQDDYVLEV
 || . | || || ||  |  ||||.. |..   |.||  ||       .|||    |.    |||     .     | ... .    ||    . | |.
egyskknafiatqmpldstvldfwrlvhdyristiiml..nqlndktcsiywpvntrsvtfgpftvghkgse.....nmnrvkvr..tlelkykeevhei

RHFQCPKWP
| |.   ||
rqfevqtwp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 884-984 9.1e-11 36.2 In-house 3-88 (130) alignment
Range on Protein: 884-984
Range on HMM: 3-88/130.0
LAYDHSRVKlrplpgkdskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTENSEEYGNIIVTLKST
| .. ||..            .||||..|   .... |. || ||  |  |||.|. |.   ..|..  . |.     |.|||  .  |. .  ... .|
lefevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtlt

K
.
d

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1174-1409 1.2e-10 35.6 In-house 46-277 (303) alignment
Range on Protein: 1174-1409
Range on HMM: 46-277/303.0
CNKEKNRNSSVVPSERARVGLAplpgmkGTDYINASYImGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVM-LPDNQS-LAEDEFVYwPSREESMN
 | .|||   |.  . ..| |.       . || |||.     |.  |.|| ||.||. |||.|| . . . ... | |..      ..|. |  .. ..
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf.prnqdflk

CEAFTVTLISKDRLCLSNEEQIIIhdFILEATQDDYVLEVRHFQcpKWPNPDAPISSTFELINVIKE-----EALTRDGPTIVHDEYGAVSAGMLCALTT
 |  .. .    |. |..  .. .    .   .    | | |..  .||  . |  .. .... | .        .   ||.     |   || .. . |
feersirvgefkrvelgdgwvlkv..lsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

LSQQLENENA-VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
    | .|.| .|. .. ...   |     .. |. ..|  .  
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1166-1268 2.2e-10 33.7 In-house 18-89 (169) alignment
Range on Protein: 1166-1268
Range on HMM: 18-89/169.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINAsyimgyyrsnefiitqhplphttkdfwRMIWDHNAQIIVMLPDnqslAEDEFVYWPS
. | |.  ||. ||| .. .   ..|| |  .    |.|||||                           ||||. || .||.| |    ..|   .|| 
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd....tddknnfwpe

REE
.|.
ked

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1166-1268 2.7e-10 33.4 In-house 17-88 (169) alignment
Range on Protein: 1166-1268
Range on HMM: 17-88/169.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINAsyimgyyrsnefiitqhplphttkdfwRMIWDHNAQIIVMLPDnqslAEDEFVYWPS
. | |.  ||. ||| .. .   ..|| |  .    |.|||||                           ||||. || .||.| |    ..|   .|| 
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd....tddknnfwpe

REE
.|.
ked

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 849-914 4.4e-10 33.5 In-house 21-85 (440) alignment
Range on Protein: 849-914
Range on HMM: 21-85/440.0
SEDF-EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDG
|  | .|     . .   .. .. |.|| |||| |||||||||| |  . |    .|||||| |..|
srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkg..vpdsdyinasying

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 872-950 1e-09 32.4 In-house 35-116 (347) alignment
Range on Protein: 872-950
Range on HMM: 35-116/347.0
PENKHKNRYINILAYDHSRVKLRPLPGKDSKHS---DYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI
  .  |||  .    | .|| | |   | |.      |||| ..   |  | || || || .|  |||.|.   .   .| |
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1203-1411 1.4e-09 32.5 In-house 46-260 (290) alignment
Range on Protein: 1203-1411
Range on HMM: 46-260/290.0
TDYINASYIMgYYRSNEFIITQHPLPHT-------TKDFWRMIWDHNAQIIVMLPDNQSLAED--EF---VYWPSREE-SMNCEAFTVTLISKdrlclSN
 ||| |...  .    ..|.|| |. ..        ..|| |. . ... .||| ...   ..  .|    | | ... ... . .||   ||      .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCksk.....ek

EEQIIIHDFILEaTQDDYVLEVRHFQCPKWPNPDAPiSSTFELINVIKEEAlTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE-NENAVDVFQVAKMINL
|.....   ...  .|.  . | | .   | .  ..  .|  |...|.    ... | |||.  |     .| |.    | .   ...| . .| |..  
eddvetRelvvk.fddeeeftvtHsllkgWnklnvq.edtktllsliqkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

MRPGVFTDIEQYQFIYK-AMLSLV
.|  ..|. ... |.   ..| ..
qralaitsalelafvdagivllai

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1177-1408 3.6e-09 31.1 In-house 45-268 (288) alignment
Range on Protein: 1177-1408
Range on HMM: 45-268/288.0
EKNRNSSVVPSERARVGLAplpgmKGTD-YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSRE-ESMNCE
 ..|   .   . .|| |        .| ||.|  .      . .| .| ||  | . .|.|. . . . |||| .   .  |   .|.||.  |..   
trdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

AFtVTLISKDRlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIkeEALTRdgPTIVHDEYGAVSAGMLCALTTLsqqL
 .  | . |.|   .. ....    .    . .    |..    .|..   |    | . |..|.  ..|..  | .|| . |.  .| |         |
rl.ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqk..PivvhssaGvGrtgtlililia...l

ENENAVDVFQVAKMINLMRPGVFTDI---EQYQFIYKAML
|    .|   . .... .|   |  |    || .... .|
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 872-1036 3.9e-09 29.7 In-house 25-159 (169) alignment
Range on Protein: 872-1036
Range on HMM: 25-159/169.0
PENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINAnyvdgynkakayiatqgplkstfedfwRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTEnsE
  |. |||    ||  | ||||. .   .   ||||||                           ||||| |. .||.. .  .|     ...||    |
tcnetknrpagplapshtrvklqrv..medlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek..e

EYgniivTLKSTKIHACYTVRRFSIRNTKVKKGQKG-------NPKGRQNERVVI----QYHYTQWPDMGVPEYAL
.|      |. . |   .    . .|  ||..  .|       .    . .. |      .||. ||. |||.  .
dy.....qlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 872-1038 4.2e-09 29.5 In-house 24-160 (169) alignment
Range on Protein: 872-1038
Range on HMM: 24-160/169.0
PENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINAnyvdgynkakayiatqgplkstfedfwRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTEnsE
  |. |||    ||  | ||||. .   .   ||||||                           ||||| |. .||.. .  .|     ...||    |
tcnetknrpagplapshtrvklqrv..medlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek..e

EYG-NIIVTLKSTKIHACYtVRRFSIR-NTKVKKGQKGN--PKGRQNERVVI---QYHYTQWPDMGVPEYALPV
.|     | |      . | ||   .. ||   .|       ... .. |      .||. ||. |||.  . |
dyqlhpavilGewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv

0048076 (Phosphotyrosine protein) phosphatases II 1300-1408 6e-09 31.3 In-house 36-140 (145) alignment
Range on Protein: 1300-1408
Range on HMM: 36-140/145.0
LEATQDDYVLEVRHFQCPKWPNPDAPIS-STFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQqlenENaVDVFQVAKMINLMRPGVFTDIE
|  ...... .. ....  ||  ..| . .... .  . |||| ..||..||   |   .|.|.|.  . .    .. |..... ...  .|||...  .
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYQFIYKAML
|..|.|.. |
qlrflyefel

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1053-1118 1.4e-08 28.4 In-house 265-342 (349) alignment
Range on Protein: 1053-1118
Range on HMM: 265-342/349.0
TGPVLVHCSAGVGRTGTYIVIDSMLQ----QIKDKSTVNVLG--------FLKHIRTQRNYLVQTEEQYIFIHDALLE
. ..||||||| ||||... .|..|.      ..   ...           . ..| ||  .||   |.|.|..|||.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1199-1265 2.5e-08 27.7 In-house 86-155 (349) alignment
Range on Protein: 1199-1265
Range on HMM: 86-155/349.0
GMKGTDYINASYIMG--YYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPS
. |  ||||| |.    .   . .| || ||| | .||...|   . .... | |.. |. .   .||  
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

subfamily_eak_pd Subfamily eak 1175-1338 1.3e-07 25.3 In-house 52-209 (332) alignment
Range on Protein: 1175-1338
Range on HMM: 52-209/332.0
NKEKNrNSSVVPSERARVGLAPLpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSRE-ESMNC
. ..|    .|| .|  | |..   .    ||||| .      ...|.|  .       ||.|. . ..  ||.| ..  |  |    |.| .  | .. 
avnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

EAFTVTlisKDRLcLsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTF-ELINVIKE
  . |.   .    .   .. |..   || .. .   .| |..   | . . |.   |  | .|.||
Gildve...rkef.v...krniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmke

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1338-1407 1.5e-07 25.1 In-house 364-434 (440) alignment
Range on Protein: 1338-1407
Range on HMM: 364-434/440.0
EEALTRDGPTI-VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
|..   ||| | ||   |   .|..|..    .||.|. |.||||  ... | ||     . .| . || .
eqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1175-1251 1.8e-07 25.0 In-house 34-109 (332) alignment
Range on Protein: 1175-1251
Range on HMM: 34-109/332.0
NKEKNRNSSVVPSERARVGLAPLPGMkgTDYINASYIMGYYRSNEFIITQHPLP-HTTKDFWRMIWDHNAQIIVMLPD
| . ||   .   ...|| |||  |    |. |||.. || . . .|..| |.  ||   ||||. ...  .|... |
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd

0048179 (Phosphotyrosine protein) phosphatases II 1295-1405 2.7e-07 25.9 In-house 33-139 (144) alignment
Range on Protein: 1295-1405
Range on HMM: 33-139/144.0
IHDFILEATQDDYVLEVRHFQCPKWPNPDAPIS-STFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSqqlenENAVDVFQVAKMINLMRPGV
. ... |  ....  |. ....  ||. ..| . . .. .  . |||| ..||..||  .|   .|.|.|.  .      .. ...... ...  .|||.
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

FTDIEQYQFIYK
..  .|..|...
vpnpgqlrfLle

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1231-1426 3.5e-07 23.2 In-house 131-323 (346) alignment
Range on Protein: 1231-1426
Range on HMM: 131-323/346.0
TKDFWRMIWDHNAQII-VMLPDNQsLAEDEFVYWpsREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST
 .||| ||.. . ... .|.||.. | .     .   .|    .     .| . |  .| . .    . . |   |  . .| |    |  .        
vedfwymiyqeqihlvylmvpddk.lkntttslf..ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpi

FELINVIKEEALTRDGPTIVHDEYGAVSAG-MLCALTTLsQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGpMTVDKN
  .|  .. |   ..    |   .|.  |  .. || .. .||.|    ..... | |   |||    . ||  ||  ..  .. |  |     |.|.
ikmihqflsekqvqnagvcvvslfgcgracsfigalyai.nqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkk.apvnkd

0038934 (Phosphotyrosine protein) phosphatases II 1015-1072 3.9e-07 25.4 In-house 76-134 (194) alignment
Range on Protein: 1015-1072
Range on HMM: 76-134/194.0
ERVVIQYHYTQWPDMGVP---EYALPVLTFVRRSSAArmPETGPVLVHCSAGVGRTGTYIV
|.. |.|.  ..|| |..   |  |  | .| .  ..   . | |.||| ||.||||| ..
ekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlva

subfamily_PTPDC1_pd Subfamily PTPDC1 1018-1114 7.5e-07 23.8 In-house 82-170 (182) alignment
Range on Protein: 1018-1114
Range on HMM: 82-170/182.0
VIQYHYTQWPDMGVPEYAlPVLTFVRRSSAARmpETGPVLVHCSAGVGRTGTYIVIdsMLQQIKDKSTVNVlgfLKHIRTQRNYLVQTEEQYIFIHD
 | ..   |.| ||.     .|. |.  . |   . | | ||| || ||||  |    .|   |. .. .    .| .| .|   .|| ||  ....
giyvynfgwkDygvasle.riLdivkvvafal..qegkvavhChaGlGrtGvliac..ylvyakrltaeka...iklvrskrpksiqtreqvelvke

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 929-1121 9.3e-07 21.7 In-house 128-310 (346) alignment
Range on Protein: 929-1121
Range on HMM: 128-310/346.0
KSTFEDFWRMIWEQNTGIIVMITNlVEKGRRKCDQYWPTENseeyGNIIVTLKstkIHacYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPD
.|  |||| ||....  .. ..    .| .      .  ||    |    | |   .      ||  .     .   .  |.|  .  ..  .|.. |  
esfvedfwymiyqeqihlvylmvp.ddklkntttslfnden....ggyqytgk...mf..innrradvsgdpkeytievlpegnsdsvicqvhhhapwkh

MGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.  |  .||.. .. .  . .  ..  | |    | ||. ..|     ..|. .    |..  .| |. ||   |..  ||  |.  ... | 
lqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia

subfamily_CG42327_pd Subfamily CG42327 1342-1407 2e-06 21.7 In-house 245-311 (319) alignment
Range on Protein: 1342-1407
Range on HMM: 245-311/319.0
TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
 . || .||   |.  .|.. |     ..||.  ..||. |.   .   |     ..|||.|||| .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

PTEN_1 1019-1071 2.2e-06 22.6 In-house 95-148 (196) alignment
Range on Protein: 1019-1071
Range on HMM: 95-148/196.0
IQYHYTQWPDMGVPEYALpVLTFVRRSSAA-R-MPETGPVLVHCSAGVGRTGTYI
..|.   ..| |.|  .  .. ....   . .  |. . ||||| ||.||.|| .
veylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

PTPc_motif_SM00404 1037-1096 6.9e-06 21.0 In-house 68-121 (140) alignment
Range on Protein: 1037-1096
Range on HMM: 68-121/140.0
PVLTFVRRSsaarMPETGPVLVHCSAGVGRTGTYIVIDSMlqQIKDKSTVNVLGFLKHIR
 ||.|....      . | ||||| ||| |..| |.   |  . .  |. ... |.|. |
kvldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerR

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1169-1224 7.1e-06 20.1 In-house 42-94 (95) alignment
Range on Protein: 1169-1224
Range on HMM: 42-94/95.0
SAQKECNKEKNRNSSVVPSERARVGLAplpGMKGTDYINASYIMGYYRSNEFIITQ
    |.|  |||   ..| . .|| |.     . .||||| .. || | | .| .|
vgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq