Gene PTPRZ1 in Homo sapiens

Synonym: HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, PTPRZ1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP100_AA protein Get Run
HsapP100_AA_1699-1994 phosphatase_domain Get Run
HsapP100_AA_2005-2284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRG_pd Subfamily PTPRG 1699-2010 2.2e-151 499.9 In-house 1-304 (563) alignment 
Range on Protein: 1699-2010
Range on HMM: 1-304/563.0
IPIKHFPKHVADLHASS--GFTEEFEtlkefyqEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLtDYINANYVDGYNRPKA
.|.|.| ||||.|||..  ||.||||       ..||.|..  ..|..|..|.||.||||.||||||.|||||..|..|..|| |||||||.|||.. ||
vpvkefakhvaslhadgdigfseefe.......alqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkska

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgRPSGRVVTQYHY
.||.|||||.|..||||||||.||..|||||||||.||||||.|||.|.||.||.. ||... .|||.||||.....|.|.||..|  . . ..|.||||
fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq..cdteklvrqyhy

TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|.|||.||||.|||||.||.|...|.....||.||||||||||||||||||..|.|||.| .||.||||||||.|||.||||||||.|.||.|.|||.||
tkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

ETEVLDSHIHAYVN
|||.|......  |
etellaeqveelkn
subfamily_PTPRD_pd Subfamily PTPRD 1698-2043 3.8e-130 430.2 In-house 4-333 (564) alignment 
Range on Protein: 1698-2043
Range on HMM: 4-333/564.0
AIPIKHFPKHVADLHASSGFTEEFEtlkefYQEVQSCtvdLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAY
.||......||| |.|.|... | |     |.....       | ...|.| ||.|||| ||||||||||.| ..  .  . .|||||...|||...|||
pipvaelkehvaklkansdlkfeee.....ykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkay

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYT
||.||||..| ||||||.||.|...|||.|.|.|||. ||..|||..|.|.||.. || .. . ||.|..|.|.|...|        . . | |.|.|.|
IAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk........ssesreVrqFhFt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||| ||||.  ..|...||   ....  ||.|||||||||||||.||.|.||..|..|.||.|....|..|.|||..|||||||.|||....||. . .
sWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn

TEVLDSHIHAYVNALLIP-GPAGKTKLEKQFQLLS-QSNIQQSDYSAA
|||  ..... .. |       . |.||. || |.  ..|. .....|
tevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefava
subfamily_PTPRG_pd Subfamily PTPRG 2019-2297 4.4e-112 370.1 In-house 17-301 (563) alignment 
Range on Protein: 2019-2297
Range on HMM: 17-301/563.0
GKTKLEKQFQ-LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGT-DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
|.......|. | |... .. |.... |..|..|||...|....|||| .|.|.| ... |||||.||.||..|..||.||.|| .|..|||||||..|.
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

QLVVMIPD-GQNMAEDEFVYWPNkDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD-DYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA
...|||..  ........||||. ||........|||..||...|.....|.|....|..... |....||.....|||....| .....|| |.|..||
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDS
|..  ||..||...|....||...|.||..|...||.|.|....|.|...|. .....|||.||....|........|  .. ...
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1699-2010 6.5e-110 362.1 In-house 2-297 (318) alignment 
Range on Protein: 1699-2010
Range on HMM: 2-297/318.0
IPIKHFPKHVADLHAsSGFTEefetLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..... .||. |.. || ..    |.| |.... ..    .|.  |..| ||.||||.||.||||.|||| .|... |  .|||||||.|||.| ||||
isvedleshvrrlre.sGell....lseeyerlsrseet..vtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkgsqkgrpSGRVVTQYHYTQ
|||.||  | ||||||.|| |  ||||.|...|.|..|...||| .||..||.  |. |.   |..|..|.|....|. .        . |.| |||||.
aaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee........esrqvrqyhyts

WPDMGVPEYSLPVLTFVRKAAYAK-RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
||| |||| .  .| .||.. .|. .. .||.||||||||||||..|..|..|..|..|..|..|.. |..|.||| .||||.||.||.|.|.||. | .
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

TEVLDSHIHAYVN
|||  |.... ..
tevdasdlrsrir
0050432 (Phosphotyrosine protein) phosphatases II 1696-1998 3.1e-102 337.3 In-house 23-304 (308) alignment 
Range on Protein: 1696-1998
Range on HMM: 23-304/308.0
VGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQevqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekdGKLTDYINANYVDGY--NR
.  ...... |.. ... .... ||||.| ...           .. .....|.||.|||| .|..||||||||       .. .|||||.|||||  ..
slklsvldllkllekaldlglleeefeellsvkp.........lleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgysskl

PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD---GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRV
|...||.||||..| ||||||.||.||.||||.|.|||.|| ||.|||| .   ||.|||.| || .|..||..||||...|.|..         .  |.
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg........dgesrt

VTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHavGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
||..||| |||.|||..  ..|.|....    ..  ||.|||||||||||||.|.|| .|.|...||.|..|. .|..|.||.. |||.|||.|....|.
vthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

EAILSKET
| ...|.|
eylklklt
0051299 (Phosphotyrosine protein) phosphatases II 1698-1993 4.8e-102 336.5 In-house 4-286 (288) alignment 
Range on Protein: 1698-1993
Range on HMM: 4-286/288.0
AIPIKHFPKHVADLHassgfTEEFETLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAY
.|..... |.|  |.        . .|.| ..|..|...|  .|  ....| |..|||| .|..||||||||  | .     .|||||.|.||||.....
eisveellklvlkll.....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkf

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqkGRPSGRVVTQYHYT
||.||||..| ||||||.||.||.||||.|.|||.||.||.|||| .||..||.. || .|..||..||||.....|... .    |    | ||..|||
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld....gdgesrtvthfhyt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|||.|||..  ..|.|.|..  | ..  ||||||||||||||||.|.|| .|.|...||.|......|..|.||...|||.|||.|....|.|..
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 1698-1998 3.8e-100 329.7 In-house 6-290 (293) alignment 
Range on Protein: 1698-1998
Range on HMM: 6-290/293.0
AIPIKHFPKHVADLHASS--GFTEEFETLKEFYQEvqsctvdlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPK
 | ...| .||....| |  .|.||.|.||.. ..          . ...... |. |||| ||..|||||||||.|....|  .|||||||..||| |.
piklekfeehvkkmkadsdlrfseeyeelkavgkd.........qavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynspr

AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD-GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgsqkgRPSGRVVTQY
 .||.|||| .| .|||||.||.....|||.|.|||||. ||..|||||  .  ||.  || .. ..|  ...|......          . . | |.||
efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..........ekeerkvrqy

HYTQWPDMGVPEYSLPVLTFVRKAAYA--KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|.| ||| |||| . ..|.|||.   |  | .. .|.|||||||||||||.| || .||.|..| .|.|||.. ..|..||.|||||.||.|||..... 
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

ILSKET
. .||.
lrkkee
0040438 (Phosphotyrosine protein) phosphatases II 1710-2020 4.1e-98 323.8 In-house 11-303 (317) alignment 
Range on Protein: 1710-2020
Range on HMM: 11-303/317.0
DLHASSGfteefETLKEFYQEVQSCTVDlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAE
||..|.        |.|......|...|   | . ...|.||.|||| .|. ||||||||  | .     .|||||.||||.|.....||.||||..| |
dllksdf.....talleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSL
|||||.||..|.||||.|.|.|.||.||.|||| ... .||.| || .|...||..|.|.... ..        | .  | ||..||| |||.|||..  
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl........gdsesrtvthfhytgWpdhgvppspd

PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYV
..| |....  | ..  |||.||||||||||||.|... ||.|...||.|...  .|..|.||.. |||.|||.|..| | | .. |.| . .|. . ..
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl

NALLIPGPAGK
  |||| . ..
lklliplaldd
0036941 (Phosphotyrosine protein) phosphatases II 1723-2003 4.1e-97 320.3 In-house 14-287 (297) alignment 
Range on Protein: 1723-2003
Range on HMM: 14-287/297.0
TLKEFYQEVQSCTVdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEV
 |.. ..|.... .   .. . .. |.|..|||| .|..|||.||||      |.  .|||||.|||||......||.||||..| ||||||.||.||.|
lllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQV--LAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
|||.|.|||.|| ||.|||| .  .| .||.| || .||.|  |..||.|.... .|        | .  |.||..||| |||.||||.  ..| |....
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt........gngesrtvthfhytgwpdhgvpespaslldfielv

AYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ---HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDS
  . ..    |||.|||||||||.||.|..| ||||..   .||.|.|. ..|..|.||.  |||.|||.|....| | ...|.| . ..
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
0046845 (Phosphotyrosine protein) phosphatases II 1725-1998 8e-97 319.3 In-house 3-279 (284) alignment 
Range on Protein: 1725-1998
Range on HMM: 3-279/284.0
KEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkDGKLTDYINANYVDGY-----NRPKAYIAAQGPLKSTAEDFWRMIWEHN
.| ..|..|.||.| .. . ...| |..|||| .|..||||||||  | . | . .|||||.|||||     ...|..||.||||..| ||||||.||.|
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VEVIVMITNLVEKGRRKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIkkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
|.||||.|.|||.|| ||.|||| .| . .||.| || .|..|  .||||...|.|...           | ||..|||.|||.|||... ..|.|.|..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.......tgesrtvthfhytswpdhgvppspedlleflrlv

AYAKR--HAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEG---TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
  . .  .  ||.|||||||||||||.|.|| .|.|...||   .|.... .|..|.||.. |||.|||.|....|.|....| |
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1699-2011 8.9e-97 319.0 In-house 5-301 (319) alignment 
Range on Protein: 1699-2011
Range on HMM: 5-301/319.0
IPIKHFPKHVADLHAssgfTEEfETLKEFYQEVQSCTVDlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..... ...  |..    | |  .|.. .....  . |   | ||.....||.|||| ||.|||..||.|..| ...|  .|||||...|||.. ...|
ievqeLkerlkalas....tge.tllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLrNTkikKGSQK-GrpsgRVVTQYHYT
|.|.||. | ||||||.||... ..||.|.||||.. |. .|||    ||||...|| .. . |. | .|...| |.   | |.       | |....||
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nk...kssevet....Revkhfqyt

QWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.||| .|||... .| .... . ....   ||.|||||||||||||.|||| ||.....||....| . ...| ||| .||..||| ||...|.||. . 
eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

ETEVLDSHIHAYVNA
.||.   ...  . .
dteievqdlrdrlkq
0047943 (Phosphotyrosine protein) phosphatases II 1714-1993 1.9e-95 314.7 In-house 11-272 (273) alignment 
Range on Protein: 1714-1993
Range on HMM: 11-272/273.0
SSGFTEEFETLKEFYQevqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWR
.... ||||.|....           .|   ...|.||.|||| .|..||||||||      ... .|||||.||||||.....||.||||..| |||||
ltllleefelllslkp.........lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwr

MIWEHNVEVIVMITNLVEKGRRKCDQYWPADG---SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLP
|.||.||.||||.|.|||.||.||.|||| .|   |..||.| || .|... ..||||...|.|..         .  |.||..||| |||.|||..  .
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg........tgesrtvthfhytgwpdhgvppsles

VLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|.|....  | ..    ||||||||||||||||.|.|| .|.|...||.|...  .|..|||| . |||.|||.|....|.| .
llefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 1717-1994 1.5e-93 309.1 In-house 22-305 (307) alignment 
Range on Protein: 1717-1994
Range on HMM: 22-305/307.0
FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdGKLTDYINANYV--------DGYNRPKAYIAAQGPLKSTA
  . .. |.. .....|.||.| .. .....| ||.|||| .|..|||.||||  | ..  . .|||||.||        |||......||.||||..| 
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

EDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE-EYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPEY
||||||.||..|.||||.|.|||.||.||.|||| .|.| .|||| || .|...|..||||.... ..       .|   .| ||..||| |||.|||..
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.......dgtgesrtvthfhytgwpdhgvpps

SLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
  ..| |....  | ..    |||.||||||||||||.|... ||.|...|||   |...  .|..|.||   ||..|||.|... | | .|
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPRA_pd Subfamily PTPRA 1721-2000 2.4e-92 304.4 In-house 31-302 (330) alignment 
Range on Protein: 1721-2000
Range on HMM: 31-302/330.0
FETLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV
 . ..| .. . .....   | . ... .||.|||..||. ||.||| |...  .  . .||||| ..|||.. . .||||||.. | |||||||||.. 
nklfreefnalPagpiq..atlelaskeenkeknrvvnilPydfsrvilsvkeGv..eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks

EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRntKIkkGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY
  |||.|.| |. . || |||| .|.  |||  |. . ..||  ||||.| ..  ..  . .. . . |.|.|.|.| |||.|||  .  .| ...|   
ativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq..ql..pdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk

AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
 ..   ||.|||||||||||||.||||..|.... |. |..|.|.|..| ||  .|||.|||.||. .| |  |  .||.
lnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
0039614 (Phosphotyrosine protein) phosphatases II 1711-1996 4.9e-92 303.8 In-house 28-292 (297) alignment 
Range on Protein: 1711-1996
Range on HMM: 28-292/297.0
LHASSGFTEEFETLKEFYQevqsctvDlgitADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGkLTDYINANYVDGYNR-PKAYIAAQGPLKSTAE
.  .... .|||.|...         |       ...| ||.||||..|..||||||||  . . |   .|||||.|||||.. ....||.||||..| |
ansktllllefeellslkp.......d....ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMIWEHNVEVIVMITNLVEKGRrKCDQYWPADGSeEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkG--SqkgrpsgRVVTQYHYTQWPDMGVPEY
|||||.||..|.||||.|.|||.|| ||.|||| .|. .||.| || ..|..|..||||.....|     .  |       | ||...|| |||.|||..
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....nges.......rtvthfqytgwpdhgvpps

SLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.  .| |....  | ..    |||.||||||||||||.|... ||.|...||.|...  .|..|.||.. |||..||.|..| |.| .. |
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0043336 (Phosphotyrosine protein) phosphatases II 1699-1991 1.4e-91 302.1 In-house 2-275 (278) alignment 
Range on Protein: 1699-1991
Range on HMM: 2-275/278.0
IPIKHFPKHVADLHASSGFTeefetLKEFYQEVQSCTVdlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..|...|....|....  .     |.. ..|..|...   .| . ...|.||.|||| .|..||||||||  | .  .  .|||||.||||||.|...|
isvkdllkallelllnlktl.....lllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgsqKGRPSGRVVTQYHYTQ
|.||||..| ||||||.||..|..|||.|.|||.|| ||.|||| .||..||.| || .....|..||||.... |        .| .  | ||.|||. 
atqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn........lgdgesrtvthyhylg

WPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|||.||||   ..| |....  | ..  |||.||||||||||||.|.|. .|.|...||.|...  .|..|.||   |||..||.|... | |
wpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
DSPc_SM00195 1719-1993 4.5e-91 300.2 In-house 4-262 (263) alignment 
Range on Protein: 1719-1993
Range on HMM: 4-262/263.0
EEFETLKEFYQEVqsctvdlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
||||.|.| ...          . ...... ||.|||| ||. |||.|||| .  .|  . .|||||||..|.|..|.|||.||||.|| ||||||.||.
eefekleestspk.........etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvwee

NVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIkkgsqkgrPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV
.|..|||.|. .|.|..|||.||| .  |.|..|.. |. ..|.     ...|...|....            | ||||.|..||| |||.   .|| ..
kvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlell

RKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|..   |..  ||.|||||||||||||....|..|.....| .|.||  .|..|.||  .|||.||| ||.....|.|
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1719-1993 4.5e-91 300.2 In-house 4-262 (263) alignment 
Range on Protein: 1719-1993
Range on HMM: 4-262/263.0
EEFETLKEFYQEVqsctvdlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
||||.|.| ...          . ...... ||.|||| ||. |||.|||| .  .|  . .|||||||..|.|..|.|||.||||.|| ||||||.||.
eefekleestspk.........etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvwee

NVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIkkgsqkgrPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV
.|..|||.|. .|.|..|||.||| .  |.|..|.. |. ..|.     ...|...|....            | ||||.|..||| |||.   .|| ..
kvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlell

RKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|..   |..  ||.|||||||||||||....|..|.....| .|.||  .|..|.||  .|||.||| ||.....|.|
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1702-2012 1.3e-89 295.4 In-house 7-302 (305) alignment 
Range on Protein: 1702-2012
Range on HMM: 7-302/305.0
KHFPKHVADLHASS--GFTEEFETLkefYQEvqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRPKAYIA
... ... . .. |  |. .....|   |.|        . . |  ..  ||.|||. .|. .|..|..|..  ..|   .|||||.|||||.| |.||.
ddlaayikearvysdkgleaqyksl...yee........eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyiv

AQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIkkgsqkgRPSGRVVTQYHYT
||||||.| .||||.|.|  |..|||.|.||| |. || ||||   .|  |.|.| |. || .  . |. |.... . .           .|.|.||. |
aqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.......dkesrtvlqyqlt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.||| |||...  .|.....   ....  | |..|||||||||||..|..| .|.....|..|..|. ||..||.| ..||| .||||.|| | | | . 
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

ETEVLDSHIHAYVNAL
.|... | ..| || |
dtsiigsnlrarvnkl
Y_phosphatase Protein-tyrosine phosphatase 1750-1990 3.1e-89 293.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 1750-1990
Range on HMM: 1-234/235.0
NKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSE
||.|||| .|..||..||||    ..... .||||||||.||...|..||.||||||| ||||||.|...|.||||.|.|.||||.||.||||   ..|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNFLVTQK-SVQ-VLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIV
.||.. |. | ...   . ||.|...|...| ..         | |.|.|||.||| |||| . ..| ..||    |..  ||||||||||||||||...
tygdikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfva

LDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
|| .|.|...|..|... ..|..|.||. .||..|||.|......
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1750-1990 3.1e-89 293.8 In-house 1-234 (235) alignment 
Range on Protein: 1750-1990
Range on HMM: 1-234/235.0
NKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSE
||.|||| .|..||..||||    ..... .||||||||.||...|..||.||||||| ||||||.|...|.||||.|.|.||||.||.||||   ..|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNFLVTQK-SVQ-VLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIV
.||.. |. | ...   . ||.|...|...| ..         | |.|.|||.||| |||| . ..| ..||    |..  ||||||||||||||||...
tygdikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfva

LDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
|| .|.|...|..|... ..|..|.||. .||..|||.|......
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1712-1993 1.8e-88 291.3 In-house 18-279 (288) alignment 
Range on Protein: 1712-1993
Range on HMM: 18-279/288.0
HASSGFTEEFETLkefyqevqsCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
.. .||.||...|          ...   . . .... |..|||| ||..||. |||| .| |..|  .|||||.|.||... |.|||.|||| .| .||
rnrtgfseeynsL.........aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndf

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS-EEYGNFLVTQKSVQVLAYYTVRNFTLRntkikkgsQ---KgrpsgRVVTQYHYTQWPDMGVPEY
|....|.... |||.|.|||.|..||..|||...  ..||.. || .... |  ...|.. |         .   .     . .|||.|. |||.|||| 
WelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle........kkkte.....leitqyqylaWpdhgvPes

SLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
. |.| ..|.   |.   .||..||||||||||||.|.|| .......| .....|.....| ||. ||||..||.||...|.. |
kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1712-2000 1.9e-88 291.6 In-house 24-297 (298) alignment 
Range on Protein: 1712-2000
Range on HMM: 24-297/298.0
HASSGFTEEFETLKEFYQEVQSCTVDLGitadssNHPDNKHKNRYINIVAYDHSRVKLAQLAekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
.  .|...||..|..  .|... . . .      ..|.||.|||| .|.|.|.||| | .    . . .||||| ....|.. .|.||.|.||..| |||
kkltgyalefqrlnsvsseieeeekeva......rkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLPV
|||..|.....|||.|||.|... |. .||| .|.|.||.. |. .| .. | ..||.... ..|        . . | | | |.|.||| ||||..  |
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk........eekerevrqlhftsWpdkgvpenatsv

LTFVRKAAYAKRHAV-GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
|...||    ...|   ||.|.|||||||.||.|..||.|.....| .| .|  .| .| .|  .||||||||||..   ||. | ..|.
ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRK_pd Subfamily PTPRK 1706-2028 2.1e-88 291.2 In-house 11-313 (314) alignment 
Range on Protein: 1706-2028
Range on HMM: 11-313/314.0
KHVADLHA--SSGFTEEFETLKEFyqevqsctvdlgitADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGP
...| |..  . || ||.|.| |                |.... .|..|||. .|.|||.|||.| .. .     .|||||...|.|.||.|.|..|||
qsiallkraegygfkeeyeslfeg..............wdaakkdenreknrsgdilaydrsrvflitidgd..pssdyinaalidsykrpaafivtqgP

LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEeYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgSQKGRPSGRVVTQYHYTQWPDMG
|..| .||||.....|   |||.|.|||.|| || .||| |..  ||.. |.  ....|| . || |....      ...|    |.| |.....||| .
lqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek......largqeeirevrqfqflgWpdhd

VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDS
|| .   .|..||.    . .  |..||||||| |||||.|..|..|. |..||.|..|   | .||..  .|.|||||.||.| ..|| |  || .  |
vPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvs

HIHA-YVNALLIPGPAGKTKLEKQFQ
...| |.... .   .  ..|...||
efkalylesirldpqtnssqlkeefq
subfamily_Ptp69D_pd Subfamily Ptp69D 1697-2000 3e-88 290.9 In-house 2-293 (307) alignment 
Range on Protein: 1697-2000
Range on HMM: 2-293/307.0
GAIPIKHFPKHVADLHASS--GFTEEFETLKEFyqevqscTVDLgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRP
|||.|.  .. .   .  .  |...|.|.|..        ..|.  ..  |.. .|. |||| .|.|.|. ||||...  |.   .|||||... ||.  
gaiaiddleealksrkrdtdfglakeyekLear.......eidk..stkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykek

KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgrPSGRVVTQY
| .||||.|. .|..||||||.| .|..|||..|| || |.||..||| .   .||. ||.  | .   .|. |.. . ..| . |     .  | |.||
kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev...edsrkvvqy

HYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
|||.|.|. ||| .  .| .....   ...  .|.||||||||||.|... |||.|||.. | .|.|| . |..||||| |||  |||||..  |.. . 
hytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

SKETEV
  .|..
ygdtde
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1699-2010 2.9e-87 288.0 In-house 11-308 (319) alignment 
Range on Protein: 1699-2010
Range on HMM: 11-308/319.0
IPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
. ...|| .  .|   | | ..   |.  .. .   .|.|  . . .| ..|| |||.|||.|.|...||| .|  ...  .||||| .|.|| |.. ||
vavpdfpayyqqlsnksdfdddltklevefrracklgvnl.adqtfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikKGSQKGRpsgRVVTQYHYTQ
||||||. | .||||||||.|.  ||..|      . || |||| .. .....| |  .||.  | |.||.. | .    .| .|.    | .||.|.  
aaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielse....dgkekdi...rkitqfhflG

WPDMGVPEYSLPVLTFVRK--AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|||.|||.|. .....|.|      | .   ..||||||||||||.||||| .|.....|  |... |.. .| ||| |||   || ||. .|.|  |  
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

ETEVLDSHIHAYVN
 ..|    . ||..
hsdvampdfpayle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1728-2027 1.6e-86 285.1 In-house 27-314 (315) alignment 
Range on Protein: 1728-2027
Range on HMM: 27-314/315.0
YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAqLAEKDGKlTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT
 |. .|         | ...  ||.|||||||.|||.|||.|  | |.| . .||.|||..||||... |||||||. .. .||||...|...  |||.|
kqdyesipggqlhpldvakkienkqknryiniiaydksrvqlp.llendph.sdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmlt

NLVEKGRRKCDQYWPADgSEEYGNFLVTQKSVQVLAYYTVRNFtlrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG
||||. .||...||| .    ||.. ||.|| .|   |||| .          |   .   | | |.||| |||||||.|..|.. ..|..   .  .||
nlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..........svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvg

PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP-AGKTKLEKQ
..|||||||||||||.| ||..|.|.. |  .... |.. .|..|  .||. ||| ||.|.|.|...  .| . .       ..|| | | .| | |..|
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeq

F
|
f
0045098 (Phosphotyrosine protein) phosphatases II 1744-1994 1.1e-85 282.6 In-house 27-273 (278) alignment 
Range on Protein: 1744-1994
Range on HMM: 27-273/278.0
SSNHPDNKHKNRYINIVAYDHSRVKlaqlaekdgkltDYINANYVDGYnrPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
 .. ..|..|||| .|..|||||||            |||||.|.|||  ||..||.||||.||..|||||.||....||||.|.|||.|| ||.|||| 
palylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKgrpsGRVVTQYHYTQWPDMGVPEYS--LPVLTFVRKAAYAKRH-------------AVGP
.||..||.| || .|..|| .||.| ....|. ... . .     | ||..||. |||.|||...   ..| ...    | ..               ||
ggsltygdftvtllseevlddytlrtllvtnltveredle....srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VVVHCSAGVGRTGTYIVLDSMLQQIqhEGTVNIFGFLKHIRSQRNY-LVQTEEQYVFIHDTLVEAIL
|.||||||||||||..... ||...  ||.|...  .|..||||..  ||..|||.|... |.| .|
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 1745-1993 1.8e-85 281.8 In-house 6-246 (249) alignment 
Range on Protein: 1745-1993
Range on HMM: 6-246/249.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD
...| ||.|||| .|..||||||||  | .  . |.|||||.|.|||......||.||||..| ||||||.||....||||.|.|||.|| ||.|||| .
allpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGT
|| |||.| || .||.|...||||...| |.        . .. | |....|| |||.|||..  ..| |....  | ..    |||.||||||||||||
gsleygdftvtllsvevkddytvrtleltnl........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

YIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|... ||.|...|..|...  .|..||||.. ||..|||.|... | | .
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1739-2010 2.1e-83 275.1 In-house 14-272 (284) alignment 
Range on Protein: 1739-2010
Range on HMM: 14-272/284.0
GITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgRRKCD
| .   .| ..|| |||...|.|.|...||| .|  ...  .||||| .. || |.. |||.||||. | .||||||||.|.  ||..|      . || 
gtdqtfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

QYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikKGSQKGRpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRK--AAYAKRHAVGPVVVHCSAG
|||| .. .....| |  .||.  . |.||.. | .    .| .|.    | ..|.|.  |||.|||.|. .....|.|      | .   ..|||||||
qywplkivikeerfkvkvdsveeseeyvvrdielse....dgkekdi...rkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

VGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVN
|||||.||||| .|.....|  |... |.. .| ||| |||   || ||. .|.|  |   ..|    . ||..
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1745-1995 3.1e-83 273.8 In-house 4-244 (250) alignment 
Range on Protein: 1745-1995
Range on HMM: 4-244/250.0
SNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRkCDQYWPAD
...|.||.|||| .|.|.|.||| | .  ||  | .||||| ...||.  ||.||.||||..| ||||||..|.....|||.|||.|...  . ||||..
akkpqnkeknryadiialdssrvvLek..ekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GSEEYGNFLVTQKSVQVLAYYTVRNFTLrnTKIKKGSQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTY
..|.||. .|. .| .. | ||.|.. |  .| || ..      |.| |.|...||| ||||.   || ...|    ...   .||.|.|||||||.|..
kaekyGdvtvsllskeefadytkrklkl..skakkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
|..|..|.....| .|..| ..| .| .|   |...|||||..  . .|. |
iaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0042113 (Phosphotyrosine protein) phosphatases II 1744-1991 7.1e-83 273.0 In-house 3-241 (245) alignment 
Range on Protein: 1744-1991
Range on HMM: 3-241/245.0
SSNHPDNKHKNRYINIVAYDHSRVKLAqlAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
....| ||.|||| .|..|||.||||    ..    .|||||.|||||.... .||.||||..| ||||||.||.....|||.|...|.|| ||.|||| 
vallpenkdknrysdilpydhtrvkls..pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR-HAVGPVVVHCSAGVGRTGT
..| .||.| || .|...|..||||.... |.        | .  | |..|||. |||.|||...  .| |.. .  | . .. |||.||||||||||||
gesltygdftvtllseehlddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

YIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
.|... ||.|...|..|...  .|..||||   |||..||.|... | |
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1713-1994 1.2e-82 272.2 In-house 11-277 (281) alignment 
Range on Protein: 1713-1994
Range on HMM: 11-277/281.0
ASS--GFTEEFETLKEfyqevqsctVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAED
...  ||.||.|.|..         .... || .|....|..||||.||||||..|||...  ... | |||||||.|.||. .|.|||.|||. .. ..
qndnaGfieeyeklaa.........igvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLrNTkiKkGSQKgrpsgRVVTQYHYTQWPDMGVPEYSL
||.|.||..|..|||.|. .|.|. || .||| |  . .||.. |.... .  | |  |.|.| ..  . ....     | |.| .||.||| |||. . 
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.er..e.sget.....reveqlaytaWPdhGvPattk

PVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
 .| | ..   . ...   |.|.||||||||||||| || .......|  ....   ....| .||..|||  || |.. ....|. 
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 1724-1996 4e-80 264.0 In-house 18-293 (297) alignment 
Range on Protein: 1724-1996
Range on HMM: 18-293/297.0
LKEFYQEVQSCTVDlGiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVI
|.. |.|... .|  | |.. |... | .|||| ... ||..||.||.. |..   .||||||.||||...||.||.||||| | .|||||.||..| ||
lskeyaeirnepve.G.tflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY-
||.| .||.||.|| ||||   . |.|.|.. |.. .|..   |.|| ....|.| ..  .      | || . .. ||| |||. .  .| ...|.   
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee..s......rkvthfqflsWPdyGvPssaaslldvlekvrek

-----------AKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
            | |. | |.|||||||.|||||.| ||  |......|||...  .|..|.|| . .||.|||.| . ...|  |..
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN6_pd Subfamily PTPN6 1710-1993 2.6e-79 261.4 In-house 21-297 (306) alignment 
Range on Protein: 1710-1993
Range on HMM: 21-297/306.0
DLHASSGFTEEFETLKEfyQEvqsctVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAqlaEKDGKLTDYINANYVDG--YNRPKAYIAAQGPLKST
.  . .||.||||.|..  .|     .   .. . ...|.||.|||| ||. .||.||.|.   |.. . .|||||||...   .  |.|||.|| |..|
eslekagfeeefeelqq..ee.....akkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclett

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS-EEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPE
 .|||||.|. | .||||.|. ||.|. || .|||.  . ||||.  ||. | . ||.|..|.... ..       |   . | | |||...||| |||.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.......kkkkeerevfqyhfksWPdhgvpk

YSLPVLTFVRKAAYAKRHA----VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
    || |...    ...      ||.|||||||.|||||.||.| .|..|...|.   ..|  . | .|.||. |||||.|| |.. .. . |
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
0037934 (Phosphotyrosine protein) phosphatases II 1744-1991 1.9e-78 258.6 In-house 4-240 (243) alignment 
Range on Protein: 1744-1991
Range on HMM: 4-240/243.0
SSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGklTDYINANYVDGYNRpkaYIAAQGPLKSTAED----FWRMIWEHNVEVIVMITNLVEKGRRKCDQ
 ...| |..|||| .|..||||||||      .|  .||||||......|   .|| ||||..| ||    ||||.||....||||.|.|||.|| ||.|
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPadGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA----------YAKRHavGPV
|||  |...||.| || .|...|..||||...|.|..... .       | |..|||. |||.|||.   ..| |....           .....  |||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt.......rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpv

VVHCSAGVGRTGTYIVLDSMLQQIqhegTVNIFGFLKHIRSQRNY-LVQTEEQYVFIHDTLVE
.||||||||||||.|... ||...    .|...  .|..|.||..  |||..||.|... | |
lVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 1712-1996 2.7e-78 257.8 In-house 5-280 (290) alignment 
Range on Protein: 1712-1996
Range on HMM: 5-280/290.0
HASSGFTEEFETLKEFYQEVQSctvDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
...  |..||..||.  .. ..   .  ......... |..|||| .|. ||.|||.| .  |..|   ||||||.. | . ...||||||||  | .||
egeeefakefqklkklsekyka...ekvysteagekeenvkknrykDilPydksrvelskieeeeg..sdYinanfikgvegkleyiaaqgPLpktlddf

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEE--YGNFLVTQKSVQVLAyytvRNFTLRNTKIKKGSQKgrpsgRVVTQYHYTQWPDMGVPEYSL
||||||.|||..||. ..|| |. ||..|||  | ||  .|.| ||... . .      .|..|  |... ...     |.|.|.|||.||| |||.   
WrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd....ddflirtLkveaqkes.....rkvyqfhYtaWPDhgvPssak

PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
..| .....   ...   |.||||||||||||| |..| . .....| .   ...|  . ..| ||. ||||.|||.... ...| . ..
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1699-1997 1.3e-73 242.4 In-house 2-287 (290) alignment 
Range on Protein: 1699-1997
Range on HMM: 2-287/290.0
IPIKHFPKHVADLHAS--SGFTEEFETLKEFYQEvqsCTVDLGITadssnhPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKA
||...| ..||  ||   .|| ..|..|. . .|    ||  |.|      ..||..||. ||| ||  |. | .....     .|||| |..||.  |.
ipvdkfgefvanghakgnegfrnqfkmldsgese...htvtvglt......ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkGSQkgrpsgRVVTQYHY
|||.|||...|. |||..||...| .|||.|| .|.|. || ||||. ....||.| ..  . ..| .|. |.. ..|.. . |..      . ||||. 
yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gak......qsvtqyqi

TQWPDMG-VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
| |.. | |....  .|.. .     ...  ...|||||..|||........  ... . || ...|  ||. |.|.  .|||..|| .|.. ..... |
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

KE
 |
fe
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1750-1992 1e-72 239.1 In-house 7-239 (239) alignment 
Range on Protein: 1750-1992
Range on HMM: 7-239/239.0
NKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSEE
|| |||| |||.|||||| | .|..     .|||||.|.  |.  ||||||.|| .. .. |||||.|.    ||||.| |.|  ..|| |||| | . .
nkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YGNFLVTQKSVQVLAYYTVRNFTLrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDS
| |. || .  .|.| | .| | .        || |.   | | |||.| ||| |||.|.  || . || .        | |.||||||||||...|.|.
ycnlrvtlrktevfadyiirtfvm........sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

MLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
||.| ... ||.|| ..| || .| ..||| ||||||| ...||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1699-1999 1.3e-72 239.3 In-house 2-284 (287) alignment 
Range on Protein: 1699-1999
Range on HMM: 2-284/287.0
IPIKHFPKHVADLHAS--SGFTEEFETLKEFYQEVQSCTVDLgiTadssnhPDNKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYNRPKA
||...| . ||. ||    ||.. | .|..  |. .. |...  .      ..||.|||. .|. .|  || |       |.  ||||| ..|||.  ||
ipvekfgefvakghakgnegfknqftvleqvtqredevthni..a......sqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekka

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKiKKGSQkgrpsgRVVTQYHY
.|.|..|. .|| .||..|...||..|||.... |. ...| |||| . |  .|.. ..  . .| | |..|.. ..|.. |.|..      . |.||..
fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdk......qqvkqyqi

TQWPDMG-VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
|.|.. | |.|.   .| . ..    .... ...|||||..|||.....  .  ... . ||....|  ||. | |.   ||| ||| || | ..| . |
tnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

KETE
 || 
fety
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1749-1990 2.7e-72 237.8 In-house 7-238 (239) alignment 
Range on Protein: 1749-1990
Range on HMM: 7-238/239.0
DNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSE
 || |||| |||.|||||| | .|..     .|||||.|.  |.  ||||||.|| .. .. |||||.|.    ||||.| |.|  ..|| |||| | . 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

EYGNFLVTQKSVQVLAYYTVRNFTLrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD
.| |. || .  .|.| | .| | .        || |.   | | |||.| ||| |||.|.  || . || .        | |.||||||||||...|.|
kycnlrvtlrktevfadyiirtfvm........sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
.||.| ... ||.|| ..| || .| ..||| ||||||| ...
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
0051299 (Phosphotyrosine protein) phosphatases II 1998-2282 6.5e-72 237.7 In-house 3-285 (288) alignment 
Range on Protein: 1998-2282
Range on HMM: 3-285/288.0
TEVLDSHIHAYVNALLipgPAGKTKLEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQ
||.  .... .|..||   . |.|.|...|. | . ...  ..||||...|.|||| |.|.| ..||| .|.|.| ||.|||||||| ||.....||.||
teisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq

HPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEAT----QDDYVLEVRHFQCPKW
.|| .|..|||||.|..| ...||. . ...  |. . |||. ....... ..|||. ||.     ... ..  .... .    .|.....|.||....|
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnw

PNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|. . |  ..  ....  ...  |...||..||  .|   .|||.|| .|..|||||. |||... |..  .|||..   |||.|.|...| .
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 2014-2285 7.9e-72 237.5 In-house 35-301 (308) alignment 
Range on Protein: 2014-2285
Range on HMM: 35-301/308.0
IPGPAGKTKLEKQFQLLSQSNIqQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslsGEGTDYINASYIMGY--YQSNEFIITQHPLLHTIKDFWRMIW
. .. ....||..|. | .  .   .||.||...|..||| ..|.| ..||| .    .||.|||||||..||  .....||.||.|| .|..|||||.|
lekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

DHNAQLVVMIPDGQNMA-EDEFVYWPNK--DEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELIS
..| ...||. . ...  |  . |||..  ....... |.|||. ||.     ..  ..  ..|. ..|.....|.||... ||. . |  ..  .... 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

VIKEEAanRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
 ...    ..||..||  .|   .|||.|| .|..|||||. |||... |..  .|||.. . |||.|||...| ....
lvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1749-1991 2e-71 235.0 In-house 2-237 (237) alignment 
Range on Protein: 1749-1991
Range on HMM: 2-237/237.0
DNKHKNRYINIVAYDHSRVKLAQLAEKdgklTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA-DGS
.|| |||| |||||||||| |     .    .|||||.|..|..  || ||||||||.|. .|||.|.|. .  ||||.| |.|. . || .|||  |  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

EEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYI
. || . |. |  . .. |||| ..| .   .|         |.. ||..| ||| |||...  .| | ..     .|    || ..|||||||||| ..
aaygvltvslkkkeefsdytvrslllskrltlk.......evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgifl

VLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|.|.||.| . .  |.|. ... |  .| |..||..||||||.|..|
vidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1699-2028 2.9e-71 234.9 In-house 3-313 (315) alignment 
Range on Protein: 1699-2028
Range on HMM: 3-313/315.0
IPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQsctvdlgitaDSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYI
||. .||  |   . .. |.|||  | .     |           .. ...| .|||| ||. .|..||||  . ..     ||||| |. ...  ||||
ipvaqfpafvnknrhtalfseefhdlpdPdiyrq..........rvaretinfkknryknilPldsarvklevidds..Pdsdyinasyiksvdddkayi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsQKgrpsgRVVTQYHY
|.|||||.. .|||||.....|  |||.|.. |  . || ||||     | |.|.. |.  |..  .  ..|....|...     ..     | |||...
asqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse.....es.....rtvtqfqf

TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|.||| ||.. .  .| ....    ...   ...|||||||||||  | .|....||... .|..| |.| .|..| |||||||.| ||.|.. | .| .
tewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr

ETEVLDSHIHAYVNALLIP-GPAGKTKLEKQFQ
.| .|  |.  ... |    . .|..|. |.|.
ntlilvihftdhlqdlhtsvdgsgrskmtkefe
subfamily_PTPN3_pd Subfamily PTPN3 1739-1992 3.7e-70 231.0 In-house 30-274 (280) alignment 
Range on Protein: 1739-1992
Range on HMM: 30-274/280.0
GITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaekdgKLTDYINANYVD----GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGR
|.. . .. |.| .|||| .|..||. |||| .        |||||||||.    . .  . |||.||||..||.|||.|.||.....|||.|.|||.||
glaisaarkpenlsknryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

RKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHC
 || ||||  . . |||.| |. .. .    | .|...|.... |.         | ..|  |..||| |||. |  .|.||..   ... .  ||||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkee........rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||.|||| .|.|.  |. |...  |..   ....| ||  ||||..|| |. ......
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0047943 (Phosphotyrosine protein) phosphatases II 2013-2281 4.1e-70 231.7 In-house 4-270 (273) alignment 
Range on Protein: 2013-2281
Range on HMM: 4-270/273.0
LIPGPAGKTKLEKQFQLLsQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD
|. .. |.|.|...|.|| .|.. . .||.||...|..||| ..|.|...||| .   ...|.|||||||. ||.....||.||.|| .|..|||||.|.
llekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HNAQLVVMIPDGQNM-AEDEFVYWPNKDE--PINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISV
.|....||. . ...  |. . |||.. .  ..... |.|||. ||.     ..  ..  ..|. ........|.||....||. . |  ..  .|.| .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

IKEEAAN--RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
...  ..  ..||..||  .|   .|||.|| .|..|||||. |||... |..  .|||..   |||.|||...| 
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1744-1991 9.3e-70 229.8 In-house 22-266 (274) alignment 
Range on Protein: 1744-1991
Range on HMM: 22-266/274.0
SSNHPDNKHKNRYINIVAYDHSRVKLAQLAeKDGKLTDYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP
  . . ...|||| .|.  ..||| | .    . ....||||||. ||..  |||.|.|||| .| .||||||....|.||||.|.| |. ..|| .|.|
eldvfgsqtknryktilPnensrvlleses.sededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

ADG----SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsqkgrpsgrvVTQYHYTQWPDMGVPEYSLPVLTFVRKA---AYAKRHAVGPVVVHCSA
 .     ||.||.. .. ...     |.||...|.... ..           |. | ||.|||. .|.   ..| .|..    . .. . ..||||||||
daedyeiserygdveikvekiverndysvrklvlkylerers..........vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|.|||| .|  .  ..|...|..|....   ..| .|  .|||.||| .|| .|..
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1750-2031 1e-69 230.0 In-house 43-315 (515) alignment 
Range on Protein: 1750-2031
Range on HMM: 43-315/515.0
NKHKNRYINIVAYDHSRVKLAQLAekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSE
| .|||| ||. || .||||  .   |    ||.|| |. ...  |||||.|||.|.. .||||.....||  |.|.|.| |  . || .|||     | 
nfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

EYGNFLVTQKSVQvlayyTVRNFTLRNTKIKKGSQkgrpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD
..|.. |   |..     .  . . |. .. ||..      | |||.|.|.||| |||. .  .| ....    . .   |...|||||||||| .| .|
kfGsikvelvsle.....actggikrkltvlkgdd.....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP-AGKTKLEKQFQLLS
|.. ...   .|..| |.. || .| |||||.||| ||.... | .| ..| .   |.  ... |   |   |..|. |.|| | 
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk
0046845 (Phosphotyrosine protein) phosphatases II 2023-2284 1.9e-69 229.6 In-house 2-275 (284) alignment 
Range on Protein: 2023-2284
Range on HMM: 2-275/284.0
LEKQFQLLSQSNIQQS-DYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYIMGY-----YQSNEFIITQHPLLHTIKDFWRMIWDHN
||..|. | . .. .. ..|.||...|..||| ..|.| ..||| ..||.|  |..|||||||. ||     |....||.||.|| .|..|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AQLVVMIPDGQNMA-EDEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQ-DDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKE
....||. .  ..  |  . |||...|..... |.|||. ||.     ..  ..  . |. .. ......|.||....||. . |  ..  .|..  ..|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

EAA--NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKEN---SVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
     ...||..||. .|   .|||.|| .|..|||||.    |||... |..  .||| .   |||.|.|...| ...
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0036941 (Phosphotyrosine protein) phosphatases II 2013-2284 2.9e-69 229.0 In-house 5-278 (297) alignment 
Range on Protein: 2013-2284
Range on HMM: 5-278/297.0
LIPGPAGKTKLEKQFQLLsQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD
|.... ....|.|.|. | .... . ..|.||...|.|||| ..|.| ...|| .   ..||.|||||||. ||.....||.||.|| .|. |||||.|.
llekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

HNAQLVVMIPDGQ-NMAEDEFVYWPNK-DEPINCESFKVTLMAEEHKclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVI
.| . .||. .   .  |  . |||.. .|..... |.|||. .|..   ...  ..  . .. |.......|.||....||  . |  ..  ...|  .
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv...llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

KE--EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLE---KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
..  ......||..||  .|   .|||.|. ....|||   ||. ||.... |..  .|||..   |||.||| ..| |. 
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1727-2027 4.6e-69 228.0 In-house 25-323 (325) alignment 
Range on Protein: 1727-2027
Range on HMM: 25-323/325.0
FYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEViVMI
| .|..    | ||.   . .|.|| |||. |.||.|.||| |  .  ||   .|||||.|.  . . . ..||| || .| .|.||.. . .  | |..
fahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.vvv

TNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLrntkikKGSQKGRpsGRVVTQYHYTQWPDMGVPEYSLPVLT---F---VRKA
.| ...|  .| .||| .   | ..| . |  .... .. |  | . .      |. .||    | | |...  |.||||...   ...       | . 
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv......kqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavser

AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA
  |. .| .|..|||||||||||..| | |.|... .|  |.||||.|..| .|  .|.| .||..|...||||..| .|.|  | ..| ...|    | 
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpl

-GKTKLEKQF
  | ..||.|
tqklniekef
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1726-2004 1.2e-68 226.4 In-house 26-295 (297) alignment 
Range on Protein: 1726-2004
Range on HMM: 26-295/297.0
EFYQEVQSCTVDLGITADSSNHPD-NKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRpkAYIAAQGPLKSTAEDFWRMIWEHNVEVIV
....|   |.    |...   .   | .|.|| ||. || |||||| . ..     ||.|| .| |..    .|. | | |.| .|||.|.....| .||
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpd..sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstiv

MITNLVEKGRrKCDQYWPADGSEEYGNFLVTQKSVQvlayyTVRNFTLRNTKIKKGSQKGRpsgRVVTQYHYTQWPDMGVPE-----YSLPVLTFVRKAa
|.... |. . || .||. .|. ..|.  |. .||.       . |  |. ...||. | |   ||| ||....|||  |..     . | ... |||  
mlnddnerdk.kcaryWsdkgvttfGdvsvvllsvs.....ereGfikrelevtkgkakar...rvvkqyqfveWPdkaverkdsassllklisevrkd.

YAKrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSH
. . .| ||..|||.||||||| .. .||.. ....| .|.|||..|..| .| |||||.||| |.. ...||.||..|..  |.
fsq.naegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_PTPRD_pd Subfamily PTPRD 2020-2297 1.8e-68 226.5 In-house 22-295 (564) alignment 
Range on Protein: 2020-2297
Range on HMM: 22-295/564.0
KTKLEKQFQLLSQSniQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
..|.|.... ....  ||.  .|| |..|..||| . |.. ..||| .|.. | ||.||||||.| || .....| ||.|| .||.|||||.|..| . .
dlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnssti

VMIPDGQNMAEDEF-VYWPNKDePINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANR
||.   . . ....  |||.|. . ......|||..||..     .. .| .|.|. .... . |||.|.  .||. . | | |   .||. ... . . 
VmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel.....adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDS
 ||..||   |    |||...  .. ....|. ||.||. |..   |. .    |||.|....||  ..  ..| .| .| .
agPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq
0040438 (Phosphotyrosine protein) phosphatases II 2017-2286 2.2e-67 222.9 In-house 14-279 (317) alignment 
Range on Protein: 2017-2286
Range on HMM: 14-279/317.0
PAGKTKLEKQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
. ..|.|...|. | . ..   .|| |....|..||| ..|.| ..||| .|.|.| ...|||||||. |......||.||.|| .|. |||||.|... 
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

QLVVMIPDGQNM-AEDEFVYWPNkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEA
...||. .   .  |  . |||. .|..... |.|||. ||.     ..  ..  . .| ..|.....|.||... ||  . |  ..  ..... ..|  
tvivmLteleelgrekcaqYwpl.getltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
....||..||  .|   .|||.|. ....|||||. |||... |... .|||..   |||.|||...| .. ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0043336 (Phosphotyrosine protein) phosphatases II 2005-2281 1.1e-66 220.4 In-house 4-275 (278) alignment 
Range on Protein: 2005-2281
Range on HMM: 4-275/278.0
IHAYVNALLIPGPAGKTKLEKQFQLLSQSNIqqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTI
.. ...||| .....||.|...|. | . ..   .|| ||...|..|||...|.| ..||| .|.|.|. ..|||||||. || ....||.||.|| .|.
vkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPnkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISK
.|||||.|... . .||. .   .  .  . |||  ....... |.|||. |||     ..  .. .. .. ..|.....|.|.....||  . |  .| 
edFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

TFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 .... ...|  ....||..||  .|   .|||.|| .|..|||||  ||.... |... .||| .   .||.|||...| 
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 2001-2284 7.5e-66 217.9 In-house 12-290 (297) alignment 
Range on Protein: 2001-2284
Range on HMM: 12-290/297.0
LDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIqqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYIMGYYQ-SNEFIITQH
 . .....  .||.  . .||.|...|. | . ..   ||| ||...|..||| ..|.| ..||| .... |  ...|||||||. ||.. ...||.||.
ipiplsvldlllllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEpiNCESFKVTLMAEEHkclsnEEKLIIQDFILEAtqDDYVLEVRHFQCPKWPNPDSP
|| .|..|||||.|... . .||. .   .    . |||.. .  ... |.|||. .||     ..  ..  . ..   ......|.|||...||  . |
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkveh.....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvp

--ISKTFELISVIKEEAA--NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
  ..  .|..  ..|  |  ...||..||  .|   .|||.|. ....|||||  |||... |... .|||..   .||.|||...| |..
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 2009-2283 9.7e-66 217.9 In-house 15-304 (307) alignment 
Range on Protein: 2009-2283
Range on HMM: 15-304/307.0
VNALLIPGPAGKTKLEKQFQLLSQSNIQ-QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYI--------MGYYQSNEFIITQH
. ..|.  . ..|.|.|.|. | . ...   .||.||...|..||| ..|.| ...|| .|||.|  |..|||||||.         ||.....||.||.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEAT-QDDYVLEVRHFQCPKWPNPD
|| .|..|||||.|... ...||. .   ..    . |||...|..... |.|||. |||     ......  . .. . .......|.||....||. .
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhg

SP--ISKTFELISVIKE--EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
 |  .. ....|  ...  |. ...||..||  .|   .|||.|. ....|||||.    ||.... |..  .|||..   |||.|||...| |.
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1719-2000 1.4e-64 213.2 In-house 17-286 (439) alignment 
Range on Protein: 1719-2000
Range on HMM: 17-286/439.0
EEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
.. | .|| .....|   |    |    .  .. |||| ...|.||.|| | ..       . ||||||..||  .| |||.||| | |..||||...|.
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviek

NVEVIVMITNLVEKGRrkcdqYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkgSQKGrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
..  |||.|||||  .     |||.|.   ||.  |       |  |..| | . | . .  ..|     | | |.||. |||  ||  .  || |.|  
ktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt..teke....rtvlqfhyiawpdknvpaqashvldflrai

AYAK-RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
  |. .. .|||||||||||||||| | ||  |.|.. |  |.| | .| .| ||. .||.  |||||.....| |   .. |
nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav
DSPc_SM00195 2022-2283 5.4e-64 211.4 In-house 1-262 (263) alignment 
Range on Protein: 2022-2283
Range on HMM: 1-262/263.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
||...|. | .|. .. . . | |. |..||| . |.|....|| ...  . ||.|||||.|| |. .....|.||.|| .|..|||||.|... ...||
klkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

IPDGQN-MAEDEFVYWPNK-DEPINCESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRD
. . .    |    |||.. ... . ....|.|. .|.|     ...|.... |......   .|...|. .||. . |   ....||....|..  . .
lteeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
||..||   |   .|||... .....||.|. ||. .. |..   |||..   |||.|.|..|| ..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2022-2283 5.4e-64 211.4 In-house 1-262 (263) alignment 
Range on Protein: 2022-2283
Range on HMM: 1-262/263.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
||...|. | .|. .. . . | |. |..||| . |.|....|| ...  . ||.|||||.|| |. .....|.||.|| .|..|||||.|... ...||
klkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

IPDGQN-MAEDEFVYWPNK-DEPINCESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRD
. . .    |    |||.. ... . ....|.|. .|.|     ...|.... |......   .|...|. .||. . |   ....||....|..  . .
lteeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
||..||   |   .|||... .....||.|. ||. .. |..   |||..   |||.|.|..|| ..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN1_pd Subfamily PTPN1 1724-1994 1.2e-63 209.5 In-house 8-272 (290) alignment 
Range on Protein: 1724-1994
Range on HMM: 8-272/290.0
LKEFYQEVQSCTVDLgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVI
 ||.|....  . |.  .. ....| |. .||| ..  |||||.|| .         |||||. |.  .  . || .|||| .|.. ||.|.||..   .
ykeiyldirkeasdf..ptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA--YA
||. ..|||.. || |||| . .|.   .  |. .|....  . ...|.|  ....   .     |.....|||.|||.||||     | |. |     .
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGs

KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
  . |||.|.|||||.||.||....|..| .|....    |.|   | ..|..|  |.|| .|  | . ...| . 
lssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1749-1992 1.4e-63 209.5 In-house 19-263 (270) alignment 
Range on Protein: 1749-1992
Range on HMM: 19-263/270.0
DNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGY-NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAdgsE
 .|. ||| .|.   ..||.|..| |   . | ||||||| |. ...|.||||.|||..| ..|||||||..|. |||.|.|.||||.||..||||   |
rgkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...e

EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsQKGRpSGRVVtQYHYTQWPDMGVPEYSL------PVLTFVRKA---AYAKRHAVgPVVVHCSAGVG
   .  ...  ..|||  ....   . |...   .||  . |.|  ..|..||| |||. .        .|. .|.       ...|  |..||||||||
pkekvkledgkikvlalseekeegyiltrlrle.ekge.errlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvg

RTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||| |.|| ... ..... |..   ....| .|  |||. ||| |.. ..|| 
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPN13_pd Subfamily PTPN13 1741-1993 1.1e-62 206.8 In-house 28-269 (273) alignment 
Range on Protein: 1741-1993
Range on HMM: 28-269/273.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltdYINANYVDGY--NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
|...... .||.|||| |.. ||..|||| . .        ||||...     .    |||.||||  |..|||.|.|| ..|||.|.|. .|||. ||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

QYWPADGSEEygNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgSQKGrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRhAVGPVVVHCSAGVG
.|||   ...    .  .  |..| .    .|..|. ..|. |. |    | |.. ....||| |||  ....|.||.. .  ..   ||.|||||||.|
rywPesknkk..lkvsnrlevellkvqkldgfvvralavkd.sesg..esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiG

RTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|.||.|..| .|. |...  ...   ....| ||. .|||..||.|.. ...|..
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_CG7180_pd Subfamily CG7180 1745-1997 1.9e-62 205.6 In-house 37-294 (296) alignment 
Range on Protein: 1745-1997
Range on HMM: 37-294/296.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRrKCDQYWPAD
  . .|. |||....| ||. || | .|  .  . .||||| |||.. ..|.||  ..| |.| ..|||........ .|..|.  .  . .. .||| .
glrkenreknrdvkvvPyDynRvvLekldGe..eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT--KIKKGSQKGRPSGRVVTQYHYTQWPD-MGVPEYSLPVLTFVRKAAYAKRH-----AVGPVVVHCSAG
. |.||...|   ... .|  . |.| |  .   . .  ..     |.|.....|.|.    ||  .  .. ..|..   ...       |||||..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
..|.| |. .|  |.....|. |..|...| .| .|. ||.. |.| .| |.| ||.| . 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRN_pd Subfamily PTPRN 1741-1992 5.7e-62 204.1 In-house 47-291 (297) alignment 
Range on Protein: 1741-1992
Range on HMM: 47-291/297.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYV-DGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQ
|.. .....| .|||. ....|||||||| . |...   .|||||  . |   |  ||||.|||| ||  |||.|.||. | |||..|.| |.| ..|..
tkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPADGSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIKKgsqkgrpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVG
||| .||| |. . |   |  . .  | || | |.| . ..         | |||.|.  ||..|||  . ..| | ||   . |    |.|||||.|.|
ywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse........trtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||.||..| .|.....    ..|   |.|.| ||. ||.|..|. |.  ...| 
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1708-1993 1.3e-61 202.9 In-house 9-293 (301) alignment 
Range on Protein: 1708-1993
Range on HMM: 9-293/301.0
VADLHASSgFTEEFETLKEfyQEVQSCTVDLgitadssnHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST
||  |. . | |....|||  .| .|||| |        . .||. ||. ||. ||. |. |..  . | . ..||||.|.|||.. |..||||||.|.|
vaakhsnk.feeqykelke..gedksctvgl........seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkkt

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLR------NTKIKKGSQ----KgrpSGRVVTQYH
  ||||.||.. .  |||.||| |. . || ||||     |||.|.| || .. ||.  ...|.....      |..|..  .    |   |.. |.|..
lvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlq

YTQWPDMGV-PEYSLpVLTFVRKAAYA-KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
 |.||. || .|.   ||  . .  .. ..   ||||||||..|.|.|.|. ..  | | . || |..|.  | .| ..   |.| |||..|.| . . .
vtdWpqdGvvreprt.vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
Carb_anhydrase Eukaryotic-type carbonic anhydrase 38-299 9.9e-60 188.9 Pfam-A 1-255 (256) alignment 
Range on Protein: 38-299
Range on HMM: 1-255/256.0
WSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLentFIHNTGKTVEINLTN---DYRVSGGVSEMVFKASKITFHWGKCN
|.|    ....| |.||...  .||||||.   .... .||.|.. . ..|.     | |.|..|...| .   .  .|||  |  ... .. ||||...
WgyeeeaeeeewsklypiakgerqsPiniktkeakydpsLkplslsydeatak...eivnnGhsvqvelddssdksvlsggpleasyrlkqlhfHWgsse

msSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGtEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNsTDKYYIYNGS
  . ||||...|.|.. |. .  ... ...|..|||| .  |  |..| .|| .||  .....| .|..   ||.|.|  | . .|||. . .|. |.||
..ekGsEHtvdgkkyaaElHlvHwnsskyksvkeAvkkedglAvlgvllkvg.keneelqklvdaLeeiktkgksatltnfdpstllPk.lrdywtYeGs

LTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLmdyLQNNFREQQYKFSRQVFSS
|| ||....| |||.|.....|..||. . . |. ..    .    |..|.|  |   .|.| .|
lttPpleEsvtWivlkepikvsseqllklrslllsaegeeeve...lvdnyRplqpLkdRvvras
0040439 (Phosphotyrosine protein) phosphatases II 2039-2282 1.3e-59 197.2 In-house 2-245 (249) alignment 
Range on Protein: 2039-2282
Range on HMM: 2-245/249.0
DYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP
.|| ||...|..||| ..|.| ..||| .|.|.| ...|||||||| |||....||.||.|| .|..|||||.|... . .||. . . .  |. . |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKE--EAANRDGPMIVHDEHGGVTAGT
. ....... |.|||. .|.     ......  . |. ..|. ...|.|.|...||  . |  .. ....|  ...  |.....||..||  .|   .||
l.ggsleygdftvtllsvev.....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

FCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|.|. ....|||||. ||.... |... .|||..   |||.|||...| |
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1698-2033 4e-59 195.0 In-house 3-277 (392) alignment 
Range on Protein: 1698-2033
Range on HMM: 3-277/392.0
AIPIKHFPKHVADLHASSGFTEEFETLKEfyQEVQSCTVdlgitadsSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGYNRPKAY
 ||. .||  | . . |. |.|||  | .   ..   ||        .....|..|||| ||. || .||||  .   |   .||.|| |.....  |||
pipvaqfpafveknrhsalffeefhdlpg..pdiypqtv........aqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekay

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGrrkcdqywpadgseeygnflvtqksvqvlayytvrnftlrntkikkgsqKGRpSGRVVTQYHYT
||.|||  .. .|||||....||  |.|.|.| |                                                   ||  . | |.|.|.|
iasqgpnaaslddfwrmvfqenvttiamvtklkegd.................................................kgd.dartvaqfhft

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||| .||...  .| |...      .   |...||||||||||  | .||.. . ..   |..| |.  || .| |.|||.||| ||. ...| .| ..
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn

TEVLDSHIHAYVNALLIPGP-AGKTKLEKQFQLLSQS
| .   |.  ... |   .   ...|  |.|. |  |
tlipvvhftdhlqdlstssdGdvrskqlkefrslkas
0045098 (Phosphotyrosine protein) phosphatases II 2018-2284 5.3e-59 195.2 In-house 6-273 (278) alignment 
Range on Protein: 2018-2284
Range on HMM: 6-273/278.0
AGKTKLEKQFQLLSQSNiqqSDYSAALKQCNREKNRTSSIIPVERSRVGisslsgegtDYINASYIMGYyqSNEFIITQHPLLHTIKDFWRMIWDHNAQL
 ....|| .|.||  ..   |... ||. .|..||| ..|.|...|||          ||||||||.||  ...||.||.|| .|. |||||.|... . 
sldlllefefllllgip...seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

VVMIPDGQNM-AEDEFVYWPNkDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEAT----QDDYVLEVRHFQCPKWPNPDSPISK----TFELISVI
.||. . . .  |  . |||. ....... |.|||. ||.      .. .. ..... .    .|.. ..|.|.... ||  ..| .      .||.  |
ivmltelvelgrekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefi

KEEAAN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLekENSVDVYQVAKMINLMRPG-VFADIEQYQFLYKVILSLVS
.|  ..             ..||..||  .|   .||..|. .....|  |. ||.... |..  .||| ..   |||.|||...| |..
realkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1736-2001 8e-59 193.8 In-house 20-274 (283) alignment 
Range on Protein: 1736-2001
Range on HMM: 20-274/283.0
V-DLGITADSSNhpDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVD---GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE
| ||  . .|..  .||.|||. .||..|  ||.|  ...      ||||| ..     |.. | ||.||.||. |  |||.|......  |||.|.| |
vpdldadiasad..enkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

KGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVV
  | || |||| .|||.||.| || .       .......||.            |  ... | . .| ..|       .. | .  .  ...  ||.||
dlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVL
|||.|.|||...| . . ..... |  |..|  .| .| ||  .||| .|| ..|.  .|  |  .|.. 
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
Y_phosphatase Protein-tyrosine phosphatase 2048-2280 2.6e-58 192.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 2048-2280
Range on HMM: 1-234/235.0
NREKNRTSSIIPVERSRVGIsSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP-NKDEPINCE
|..||| ..|.| ...|| . . |.. .|||||.|..|| ....||.||.|| .||.|||||.|... ...||. . ...  |    ||| ...|. ...
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

SFKVTLMaeeHKCLSNEEKLIIQDFILEATQDD-YVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQ
..||.|.   .|  ..|.. ..... |. ....    ||..... .||. . |   .. ..||  .... ....||..||  .|   .|||.|| .|..|
dikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
||.|..|||.|. |..   |||.. ..|||.||||.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2048-2280 2.6e-58 192.6 In-house 1-234 (235) alignment 
Range on Protein: 2048-2280
Range on HMM: 1-234/235.0
NREKNRTSSIIPVERSRVGIsSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP-NKDEPINCE
|..||| ..|.| ...|| . . |.. .|||||.|..|| ....||.||.|| .||.|||||.|... ...||. . ...  |    ||| ...|. ...
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

SFKVTLMaeeHKCLSNEEKLIIQDFILEATQDD-YVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQ
..||.|.   .|  ..|.. ..... |. ....    ||..... .||. . |   .. ..||  .... ....||..||  .|   .|||.|| .|..|
dikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
||.|..|||.|. |..   |||.. ..|||.||||.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0042113 (Phosphotyrosine protein) phosphatases II 2040-2282 1.9e-57 189.8 In-house 1-242 (245) alignment 
Range on Protein: 2040-2282
Range on HMM: 1-242/245.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPN
|| ||...|..||| |.|.| ...|| .|. .|. ..|||||||. ||.... ||.||.|| .|..|||||.|... . .||. .   .  .. . |||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

kDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAA-NRDGPMIVHDEHGGVTAGTFC
 .|..... |.|||. |||     ......  . .. ..||...||.|...  ||  . |  ..  ..... ...  | ...||..||  .|   .|||.
.gesltygdftvtllseeh.....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

ALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|. ....|||||  |..... |... .|||..   .||.|||...| |
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN14_pd Subfamily PTPN14 1741-1993 3.4e-57 188.7 In-house 40-296 (300) alignment 
Range on Protein: 1741-1993
Range on HMM: 40-296/300.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgkLTDYINANYVDGY--NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
. .... |.|..|||. ... |...||.|.   |.    |.||||  .      . . ||.|||||. | .|||.|.||..|..|||.|.  |.|. |. 
llstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPADGS----EEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---------A
.|.| ..|     |.|.| ||.| ..    .. . ..|.    |.  .      | |    || ||| ||||   . | ....    .|.         .
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske..e......rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskes

VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
  ||.|||||||||||  |. | ... ..|. ...|   |...| || .||||  || |....|.. .
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2018-2287 3.7e-57 188.8 In-house 20-287 (319) alignment 
Range on Protein: 2018-2287
Range on HMM: 20-287/319.0
AGKTKLEKQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
.|.|.|||.|.||.... .  ... | |. |..||| . |....|.|| .|.| | ||.||||||.| || . ..|| || || .||.|||||.|.... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

LVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDY-VLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAA
 |||. . ..  . ..   ... .. .   . |||  ||..     |..||... |.  ...    || |||  .||. | | . |   .|.  |..   
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel.....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre

N-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
.  .||..||   |    |||..|   . ....|. .||....... . |. .    |||.|.|...|  |.. .
ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0051429 (Phosphotyrosine protein) phosphatases II 1779-1994 7.7e-57 188.2 In-house 3-226 (272) alignment 
Range on Protein: 1779-1994
Range on HMM: 3-226/272.0
LTDYINANYVDGYNR---PKAYIAAQGPLKSTAEDFWRMiWEHNVEVIVMITNLVEKGRRKCDQYWP------------ADGSEEYGNFLVTQKSVQVLA
|..||||..|.||.|   |.......|||. ||.||||. .|... .||......|.|| |||.|||            .. . .||.. ||  |...| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

YYTVRNFTLRNTKIKKGSqkgrpsgRVVTQYHYTQWPDMGVP-EYSLPVLTFVRKaayakrhaVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVN--
.|..|...|...   . .       | |...|||.|||.||| |. | .| ....         |||.||||||..||||...|. .|... .|  |.  
dyilrellltlllsagea.......revmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddY

------IFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
      ........|.|| . |||||||.|... |.|.. 
lltnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2018-2295 1.1e-56 187.3 In-house 17-292 (318) alignment 
Range on Protein: 2018-2295
Range on HMM: 17-292/318.0
AGKTKLEKQFQLLSQSNIQQSDYSAaLKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |...|..... ||.|. . . . . |...|. |||   |.. ...|| .. |.|| |.|||||.|| || .....| .| || .||.|||||.|. |..
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

LVVMIPDGQNMAEDEF-VYWPNKdEPINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKtFELISVIKEEAA-N
..||. . .. . .    |||.| .... .. .|.|. | .      ...... | .. |. . . .|| ... .||. ..| |   .|......  . .
vivmltqeeergkakvhryWPsk.gsrsygklvvelkeevel.....sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaq

---RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL
     ||..||   |   .|.|.|. .|......|. |||.|. |..   |. .    .||.|.|.|.|  . . . |  .. |
qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2020-2286 1.4e-56 187.0 In-house 26-293 (298) alignment 
Range on Protein: 2020-2286
Range on HMM: 26-293/298.0
KTKLEKQFQLLS--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS-LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |.....|| |.  .|.|..  ...| |. |..||| ..||... ||| ...  . | .||||||.. .| ..| ||.||.|| .|..|||||.......
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

LVVMIPDGQNMAE-DEFVYWPNKDEpINCESFKVTLMAEEHKClsneeKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEeAA
 .||. . ... . .   |||.. .  . ....|.|...|..      .||.. .... .. .   |||...  .||. . |  .|  ..|.. ..    
tiVmltnleeldktkyhkywPdegk.etygeitvsllskeefa.....dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
..    |.||.  .|   .|||.|. ... ...||..|||.|| |..   |||.    ||| |.|...|  ... 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_PTPN23_pd Subfamily PTPN23 1713-1992 3.6e-55 181.8 In-house 13-279 (288) alignment 
Range on Protein: 1713-1992
Range on HMM: 13-279/288.0
ASSGFTEEFETLKEfYQEVQscTVDLGITADSSnhpdNKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDF
  ... ..|. |.. .|. .  . .  |..       . .|||. .|. |||.||||       |.  ||||| .| .       .||.|.||.||. ||
gktaldkkfkeleq.kqdke..arkrsiaiakl....yseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG--SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqKgrpsgRVVTQYHYTQWPDMGVPEYSL
|.|..|  ..||||...  |.|. |.|.|||.|   ....|.. || |||. . ..  |...|.  . ..   .     . |.  ..|.||..|||.   
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada...v.....ksvshlqltsWpelGvPasPe

PVLTFVRKAAY----AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ-HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
 .| |. ..       .|..  |.||||||||||||.. .. . ..... ..| ..|   ....| || . ||..||. |  .  .||
tllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRK_pd Subfamily PTPRK 2040-2282 4.5e-54 178.4 In-house 35-276 (314) alignment 
Range on Protein: 2040-2282
Range on HMM: 35-276/314.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPN
. || |. ||||||.  |.. .|||| . .. |.  .|||||..| .| ....||.||.|| .|.|||||...|.|.  .||. . .. .      |||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

KDEPinCESFKVTLMAEEHkclsnEEKLIIQDFILEA--TQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
. |    . .||.|.  |      ...|... | .|    . . . |||.||  .||. | | |.|  ..|.  .|.  ....|...||   |.  .|||
dtev..ygdikvelvetel.....laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
.|.....  .|.|. |||....| .   .. .    |||.|.| |||  
iaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1708-1990 3.9e-53 175.1 In-house 3-274 (287) alignment 
Range on Protein: 1708-1990
Range on HMM: 3-274/287.0
VADLHASSGFTEEFETLKEFYqevQSCTVDLGITADSSNhpdnKHKNRYINIVAYDHSRVKLAQLAEKdGklTDYINANYVDGYNRPKAYIAAQGPLKST
|.....     .|...|||     .| |. .  . .  .     .|||| ... .|..|| |.. .|. |  .|||||||| .|.. .|.||||||. .|
veerrvkddvdkevdalkeds...esstatfkaaeelaa....vkknryadvlPiddtrvllsaegel.G..sdyinanyvasytddeafiaaqgPiaat

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADgseeYGNFLVTQKSVQVLAYYTV-RNFTLRNTKIKKGSqkGRpSGRVVTQYHYTQWPDMGVPE
  ||||...|... .....|  ||..| || .|||          .|   || .| |     ... |  .. .    .|   ||| |... .||| ... 
vrdfwravletrsasvitmtreveearlkcykywPer....evPmrvGGysvvlldydikePeygvralrlidle..tr.earvvkqldllswPdkvlaP

YSLPVLTFVRKA---AYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
 .. .. || .      ..|    |||.|||...|.||.|... .  .... .  | |..   . ..| .|. |||.  |. .. ..||
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0041856 (Phosphotyrosine protein) phosphatases II 1750-1998 1.5e-52 173.2 In-house 1-176 (182) alignment 
Range on Protein: 1750-1998
Range on HMM: 1-176/182.0
NKHKNRYINIVAYDHSRvklaqlaekdgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgrrkCDQYWPadgseey
|..|||| .|. |||||              ||||||...|. ... .||.||||.|| .||.||..|... .||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gnflvtqksvqvlayytvR-NftlrntkikkgsqkgrpsGRVVTQYHYTQWPDMGVPEySLPVLTFVRKAAYakrhAVGPVVVHCSAGVGRTGTYIVLDS
                                        | ..||.|..|||.|||.    .| |....        |||.||||||||||||..... 
..................ell..................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaayl

MLQQiqhegTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
|...      |...  .|..||.|.  |.|..||.|... | | .| |.|
mkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_PTPRA_pd Subfamily PTPRA 2023-2283 1.4e-51 170.3 In-house 34-295 (330) alignment 
Range on Protein: 2023-2283
Range on HMM: 34-295/330.0
LEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI
. ..|. |  ..|| . . .| |. |.||||   |.| . ||| .| ..|.  .||||||.| || . ..|| .| |. .|..|||||||..... .||.
freefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml

PDGQNMAEDE-FVYWPNKDePINCESFKVTLMAEEHKCLSNEEKLIIQdFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDGP
 . ..  |.    |||..   .     .|..  |.        |...|  . .||... .  || |    ||.   |.     ..|.  .|.   .  ||
telkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagp

MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
..||   |   .|||..| ....... |. |||... | . | || .    |||.|.|||.|   
ivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1727-2000 3.2e-51 169.2 In-house 21-284 (307) alignment 
Range on Protein: 1727-2000
Range on HMM: 21-284/307.0
FYQEVQSCTVDlGITADSSNhpDNKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMI
 ....   | . |.|... .   | .|||| .. . |..|. .    . ||  .||| |||.    .|| .|.|||||..|  .|| |. ...|| ..|.
efrvlakktpe.gvtveafs..antdknryqdvkcqdkgrivv....kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLVEKGRRKCDQYWPADGSEEygNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGR--PSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRkaayAKRH
 ...| .. ||.||||..  ..  .  . .     .|   .....  .  |.  . |       | .... ...||| |||.  |  . ..     | | 
ckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle....avry

AVGPVVVHCSAGVGRTGTYIVLDSMLQ-QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
   ||||||||||||.|| . .  . .  |. .   ..  ... .||||.| .||| ||...|  |.|  | .  | 
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket
0037934 (Phosphotyrosine protein) phosphatases II 2040-2282 3.1e-50 166.3 In-house 2-241 (243) alignment 
Range on Protein: 2040-2282
Range on HMM: 2-241/243.0
YSAALKQCNREKNRTSSIIPVERSRVGIsslsgEGTDYINASYIMGYyqsNEFIITQHPLLHTIKD----FWRMIWDHNAQLVVMIPDGQ-NMAEDEFVY
.| ||...|..||| |.|.| ..||| .     ||.|||||..|...   . .|.||.|| .|..|    ||||.|... . .||. . . . .|. . |
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPnkDEPiNCESFKVTLMAEEHkclsnEEKLIIQDFILEATQ-DDYVLEVRHFQCPKWPN----P-DSPISKTFELISVIKEE-----AANRDGPMIVHD
||  .|  ... |.|||. |||      .. ..  . || .. ||....|.|...  ||     .  ... . .. .  . ||     |....||..|| 
wp..gev.tygdftvtllseeh.....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

EHGGVTAGTFCALTTLMHQLekenSVDVYQVAKMINLMRPG-VFADIEQYQFLYKVILSL
 .|   .||..|. .....|    .||.... |..  .||| ..   .||.|||...| |
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1748-2006 3.4e-50 165.5 In-house 46-298 (305) alignment 
Range on Protein: 1748-2006
Range on HMM: 46-298/305.0
PDNKHKNRYINIVAYDHSRVKLaqlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 ....|||| ..   |. ||||     .     .|| ||||     || .| .| ||. |  ||| | ....|| | |. ||.||| .|| .|....  .
aqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

EYgNFLVTQKSVQVL--AYYTVRNFTLRNTKIKKGSQKG---RPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayakRHAVGPVVVHCSAGVGRTGT
.  .|   .. ..|   .  |..  .  ..|...          . | ||.||. .||| |||   | .| .. ||    | . ||.|||||||.||||.
vl.efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgs

YIVLDSMLQQIQHEGTVN-IFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKetEVLDSHIH
 ..|. .|.|.     ..     |..|| |||  .||..||.|.|. ... .. |  ..|| ...
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk..klldeevk
subfamily_PTPRB_pd Subfamily PTPRB 2021-2289 6.3e-50 164.9 In-house 25-291 (293) alignment 
Range on Protein: 2021-2289
Range on HMM: 25-291/293.0
TKLEKQFQLLSQSNIQQSDySAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
... .... |.. . .|.  .|| ...||.||| . |.| . ||| ...|.. .|.|||||.|| || . .||| || || .|..|||||.|..... .|
lrfseeyeelkavgkdqav.kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEAtqDDYVLEVRHFQCPKWPNPDSPiSKT---FELISVIKEEA--A
|. .  .        |||...||..  . ||||.|||..     |. .|... .|   ..   .||...   ||. . | .||    ...  ..|..  .
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.....edwvirelkiek..ekeerkvrqyhftsWpdhgvP.ektktlldfvrtvreaiekt

NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEE
....|..||   |   .||| || .|....|.|. ||.. .   .   |  .    .|| |.....|.|.....||
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee
subfamily_Ptp69D_pd Subfamily Ptp69D 2022-2284 2.8e-49 162.9 In-house 23-287 (307) alignment 
Range on Protein: 2022-2284
Range on HMM: 23-287/307.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
 |.| .. | ...|.. . ... |. |  |||   |.. .. || .. . |.  .||||||.| || ....||. | |.  ||.||||||.. . .|.||
glakeyekLeareidk.stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

IPDGQNMAED-EFVYWPNKdEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDG
. . ... ..    |||.  . .. ..  |.|. ||..    . .| .     |... .   .|  ..   |..   | .    ..||. ..|   .  .
lsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
|..||   |   .|.| ||. |..||..|..||.... | .   |. ..  .|||.|||. .|   |
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1717-1991 3.3e-49 162.3 In-house 8-257 (267) alignment 
Range on Protein: 1717-1991
Range on HMM: 8-257/267.0
FTEEFETLKEFYQEVQSCTVdlgitadsSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgkltdYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIW
. .||| .|.  .. . ..         |   .|. .||. . . ||..|| | .  |       |||| ||.||.. .|.|. |.||| |  ||. .| 
iekefelikkisdtsstisq........siaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvih

EHNVEVIVMITNLvekGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVrnFTLrNTKIKKGsqkgrpSGRVVTQYHYTQWPD-MGVPEYSLPVLT
...| |||..|.    .  .  ..||     ...| .. | .   .    | .   || . |.|.       | . || |.| .|        |  |.. 
dqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqi..itl.elkfkne......sahnvtlyyykkwnintnnkpylkplfg

FVRKAAYakRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
 . |       .  |.||.||.||||.||..|.||.|.....||...|| ||..|||||  ||.| |.|..||..|.|
ilaknql..engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2019-2286 4.1e-49 162.2 In-house 19-282 (288) alignment 
Range on Protein: 2019-2286
Range on HMM: 19-282/288.0
GKTKLEKQFQLLSQSNIQQSDYSaALKQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
..| ...... |.. . ..|.   . .  | .|||   |.|..  || .  |  ..|.|||||||| |. .....| || || .|..|||......... 
nrtgfseeynsLaalektksvta.grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

VVMIPDG-QNMAEDEFVYWPNKDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEatQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAAN
.||. .  ..  .    |||..|.| |  |..|||. ..     ..|. . . ..||  ..   ||. ..|   ||. . | ||.  .||.. .|    .
ivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.....eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
  ||.|||   |   .||| || .|....|.|. .||  . . .   |. .    .||.|.|.|.|||.. .
dtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2043-2287 1.4e-48 160.2 In-house 4-246 (250) alignment 
Range on Protein: 2043-2287
Range on HMM: 4-246/250.0
ALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNkDEP
| |  |.|||| . ||... ||| . . .  . .||||||.. || ... ||.||.|| .||.|||||....... .||. . ... .    |||  ...
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.eka

INCESFKVTLMAEEHKCLSNEEKLIIQdfileATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTT
 .  . .|.|. .|..      ||..       ..      ||...   ||.   |   |  .||.. .. .  .  ..|.||.   |   .|.|.|. .
ekyGdvtvsllskeefadytkrklkls.....kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
....|.||. |||..| |..   ||..    ||| |.|..||  . . .
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2020-2287 7.1e-48 158.3 In-house 21-287 (305) alignment 
Range on Protein: 2020-2287
Range on HMM: 21-287/305.0
KTKLEKQFQLLSQSniqQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
...||.|...| .    .. .    |. |..|||...|.. . .|. ..  . .. .|||||||. || .....|..| || .|..||||.|..   . .
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMIPDGQNMAEDE-FVYWPNKDEP-INCESFKVTLMAEEHKclsneEKLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISKTfELISVIKE--EAA
||. . ..  .|    |||..     . ..|.|.|  |..      . .|. .. .    .|.    | ..|  .||.   | . |  |.|.||.  .. 
vmltklveggkdkCrqYWpesktekkefgefsvelksekta.....sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat.sllslikrvqkdq

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
..|   |..||   |   .|.|.|.   . .|.||..|||..| | .   |...    .||.||. ..  |. . .
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0036282 (Phosphotyrosine protein) phosphatases II 1780-1987 7.6e-48 157.8 In-house 2-164 (174) alignment 
Range on Protein: 1780-1987
Range on HMM: 2-164/174.0
TDYINANYVDGYNRPKAYIAAQGPLKstaedFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAdgseeygnflvtqksvqvlayytvrnftlrntkikk
.|||||...|.. ... .|| ||||.     ||.|..|......|| ....|.|. || .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gsqKGRPSGRVVTQYHYTQWPDMGVPEYSLpVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQhEGTVNIFGFLKHIRSQRNYLVQT
   .     | . ||.|. |||.|||. |  .|.||. .  |  .   |||.|||||||||||| .... ||...  |..|... ... .|.|| . |||
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

EEQYVFIHD
..|| |...
psQyrflyy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2019-2285 8.6e-47 154.5 In-house 18-280 (287) alignment 
Range on Protein: 2019-2285
Range on HMM: 18-280/287.0
GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
|..  ..||..| | . .. .   .. . |..||| . |.. .  || .    ||  |||||..| || ....|||.. |. .|...||..|.|.| . .
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMIPDGQ-NMAEDEFVYWPNKDEpINCESFKVTLMAEEHKCLSNEEKLIIQDfileATQDDYVLEVRHFQCPKWPNPD---SPISKTFELISVIKEEAAN
||. . . |  |  . |||...  .    ....|. ||..    | || ..      ....  ..|. .|  .|..     .| .  . .   .|..  .
vmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevkn....knkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
 .....||   .   ...|||  | ... ..|  .||.|| |     .||    .|||.|.....|  ...
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1751-1991 3.8e-45 148.8 In-house 57-281 (290) alignment 
Range on Protein: 1751-1991
Range on HMM: 57-281/290.0
KHKNRYINIVAYDHSRVKLaqlaeKDGKLTDYINANYVDGYNRPkaYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE--E
 .|||| ..|  | .|| |     |||   ||. ||||.| . .  .| .||.||.|. |.|||. ...| .|||. .|.|.|. ||.||.|    |   
fkknrykdvvcndktrvil.....kdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGNFLVTQK-SVQVLAYYTVRNFTLRNTKikkgsqKGRpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVrkaaYAKRHAVGPVVVHCSAGVGRTGTYIVLD
.|.. |.   . .  |    . ...|. .      .|.    ..  ..   |||  |.  .| .|  .    .. |.| ||||||||||.|||||.. ..
fGeitvlcseeddkdaniikktlsvrdkd......sGk..ehklkhlkikswpdksvalstlallrtl....rilrkasGpvvvhcsaGiGrtGtfvaie

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
  || . .   ... .  . .|  |   || . ||. . . |..
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2041-2281 4.8e-45 148.8 In-house 42-277 (315) alignment 
Range on Protein: 2041-2281
Range on HMM: 42-277/315.0
SAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNK
  | |  |..|||   ||. ..||| .  |   ...||.||..| || . . .| .| |.  ..|||||......   .||. .  .  .     |||.|
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

dePINCESFKVTLMAEEHKclsneEKLIIQDFilEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTFCAL
   .    . ||.. ||..     ... .. .    . .| . ||  ..   ||. . | . .   .||  .|    |  |...|| . |   .|||..|
..kviyGkitvtrkseevn.....teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitl

TTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 ....|.| || .|||.. . .  .| .. . .|||||.|...| 
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
0049260 (Phosphotyrosine protein) phosphatases II 1787-1987 5.8e-45 148.0 In-house 1-144 (152) alignment 
Range on Protein: 1787-1987
Range on HMM: 1-144/152.0
YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWpadgseeygnflvtqksvqvlayytvrnftlrntkikkgsqkgrp
..|||..|...||.|||.  |..|||||..|... .|||.|.|.|.|. ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

sgrvvtQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLqqiqheGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
      ||....|||.|||. |  .| ...    ....  |||.||||||||||||..... ||        |... .....|..|.. |....|. |..
......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

D
.
e
subfamily_CG7180_pd Subfamily CG7180 2026-2284 7.5e-45 147.8 In-house 20-291 (296) alignment 
Range on Protein: 2026-2284
Range on HMM: 20-291/296.0
QFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG
. .|   ..... |  ..|.. ||||||   ..| .  || ...| ||  .|||||.|. .. . .|.|.|. |  .|...|||...|.... ||.. . 
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

QNMAEDEFVYWPNKDePINCESFKVTLMAEEHKCLSNEEKLIIQDF--ILEATQDDYVLEV---RHFQCPKWPN-PDSPIS--KTFELISVIK---EEA-
 ..|.    |||||    .   . | .. |..    .  .. ..     | ... . . |.   ..||  .|.     |.|     ||.  ..   |.. 
fdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
  .  ||..|. . |.  .| ..|.   . ..|||. |||.. .|..   ||..   .|.|...| |.|  | 
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN12_pd Subfamily PTPN12 2022-2286 1.1e-44 147.5 In-house 9-280 (290) alignment 
Range on Protein: 2022-2286
Range on HMM: 9-280/290.0
KLEKQFQLLSQSNI---QQSDY--SAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
...|.|| | . .    ... |  .|. |. |..|||   |.| . ||| .|  ..|   |||||..| | ... |.| .| || .|..|||||||..| 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

QLVVMIPDGQNMAEDEF-VYWPNK-DEPINCESFKVTLMAEEHKclsnEEKLIIQDfiLEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEE
..|||.    ...      |||.. .|... ..|.|||..|..     .. ..|.   |......   .|. |.  .||. . | |.   .|||. ..| 
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav....dddflirt..LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

AANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
  . | |..||   |   .|| .|.    ..|..|.    .||...   .   |. .    |||...|| ...||...
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2020-2281 1.2e-44 147.9 In-house 33-289 (319) alignment 
Range on Protein: 2020-2281
Range on HMM: 33-289/319.0
KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
.|||| .|. ...  .. .| . |  . |..|||   |.. ....| .  | | |..||||||.. || . . .| .| ||  |..|||||||..|.  .
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMIPdgqnmAEDEFVYWPNKDEpINCESFKVTLMAEEHkclSNEekLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKE-----EA
|..       .    |||.| . |. | ||| . . |    ..|   ...|. |   ..   . ... |    ||.   | . . .|. ..|      . 
vllt.....kdkcsqywplkiv.ikeerfkvkvdsvee...tae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdy.psdlmrlvkkvrhltsk

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 |   ...||   |   .|.. .| .|......|. ||||.. . .   |. .  |. ||.|.|  .| 
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0046846 (Phosphotyrosine protein) phosphatases II 1778-1989 1.6e-44 147.1 In-house 10-169 (176) alignment 
Range on Protein: 1778-1989
Range on HMM: 10-169/176.0
KLTDYINANYVDGYnrpkAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYgnflvtqksvqvlayytvrnftlrntki
   ||||||...|.    ..|| |||| .| .||..|..|......|..|..||.|| ||..|||   ....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

kkgsqkgrpsgrvvtQYHYTQWPDMGVPEYsLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDsmlqQIQHEGTVNIFGFLKHIRSQRN-YLV
               ||... |||.|||..   .|....    | ..  |||.||||||.|||||.....     ...|  ....  |...|.||  . |
...............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTEEQYVFIHDTL
||.||| |... .
qtpeQyrflyefe
0049772 (Phosphotyrosine protein) phosphatases II 1741-1994 3.4e-44 147.2 In-house 37-281 (314) alignment 
Range on Protein: 1741-1994
Range on HMM: 37-281/314.0
TADSSNHPDNKHKNRYINIVAYDhSRVKLAQLAEKDgklTDYINANYVDGYnrpKAYIAAQGPLKSTAEDF----------WRMI--WEHNVEVIVM---
|   .... |..||||..|. .| .||.|  |  ..   .|||||.||||.   ...||.||||. | .||          |||.  ...|| .|||   
tilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ITNLVEKGrrkcdqywpadgseeygnflvtqksvqvlAYYTVRNFTLRNtkikkgsqkgrpS--------GRVVTQYHYTQW
                  ...| ..|                             ...|.... | .            .         | . .|... .
evladelsrLdaAlgKtpllildgng.............................neptaadlellk............eelydpelferlgikylripv

PDMGVP--EYSLPVLTFVRKAayakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIqhegTVNIFGFLKHIRSQRN-----YLVQTEEQYVFIHDTLVEA
|| ..|  |. . .| |...|     .. |||.|||.||.|||||..|.. .. .      |..   |...|..|       .... |||.||.. | |.
pDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley

IL
. 
lk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1723-1991 8e-44 144.4 In-house 9-267 (281) alignment 
Range on Protein: 1723-1991
Range on HMM: 9-267/281.0
TLKEFYQEVQSCTVDLGI-TADSSNHPDNKHKNRYINIVAYDHSRVKLAQ-LAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV
|| .| ||.     |     .   |.| |..||||.|| . | |||.|   . .|  . |||| |||.      . || .||| | |  |||||||. | 
tlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnk..nstdyihanyirspflkrgyiltqgpkketradfwrmiwqent

EVIVMITNLVEKGRRKCDQYWPADGseeYGNFLVTQKSVQVlAYYTVrNFTLRNTKIKKgSQKGrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAay
  |||. ...|  | || .|.| .    .  . . . ||.     || | .|  |...  | .|    |..|.. . .|||  ||| |  .|  .||   
taivmlcqfletnrekcaeyfprna...hcclqfdklsvsy.edstv.nkslvttrlnl.syeg..etrlithwlwkewpdwqvpessevmlkilrki..

akRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV-NIFGFLKHIRS-QRNYLVQTEEQYVFIHDTLVE
  |    | |.||||||||.|| . ..  || |.   |. .|   . |.|   |   ||| .||..|   |..
..rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2019-2285 1.1e-43 144.1 In-house 18-285 (290) alignment 
Range on Protein: 2019-2285
Range on HMM: 18-285/290.0
GKTKLEKQFQLLSQSNiQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGT---DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
|... ..||. | ... ..     .| . |...|| . |.. .  |. .  .||.     .||||.|| || .....|.|| |. .|..|||..||... 
gnegfrnqfkmldsge.sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

QLVVMIPDGQNMAED-EFVYWPNKDEPInCESFKVTLMAEEHKCLSNEEKLIIQDfileATQDDYVLEVRHFQCPKWPNPD---SPISKTFELISVIKEE
  .||. . ... ..    |||..|     . |...|. ||.     | || ...     .....  .| ..|   |.. .    | . .  .  ..| .
tiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevkn....knsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq

AANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
  . .....||   .   ...|||..| . . ..|  .||.|| |     .||     .|||......|. ...
rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0043147 (Phosphotyrosine protein) phosphatases II 1779-1986 1.5e-43 143.8 In-house 4-154 (172) alignment 
Range on Protein: 1779-1986
Range on HMM: 4-154/172.0
LTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLvekgrrkcdqywpadgseeygnflvtqksvqvlayytvrnftlrntkik
 .|||||.|.|.|  |. .|| |||| .| .|||||..|... .||..|.|                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

kgSQKGRPSGRVVTQYHYTQWPDMGVPeYSLPVLTFVRKAAY-AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLqqiqheGTVNIFGFLKHIRSQRNYLVQ
     . .  | . ||.|. |||.|||  .  .| |..     . .   |||.|||||||||||| .... ||        ....  ....|..|.. ||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TEEQYVFIH
...|| |..
npsqyrfly
subfamily_PTPN6_pd Subfamily PTPN6 2018-2288 3.4e-43 142.8 In-house 23-302 (306) alignment 
Range on Protein: 2018-2288
Range on HMM: 23-302/306.0
AGKTKLEKQFQLLSQSNIQ-QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ--SNEFIITQHPLLHTIKDFWRMIWDHN
 .|. .|..|. |.|.. . . . . . |. |.||||  .|.|.. .|| ... |  |.|||||.||..  .  ....| ||  | .|..|||||.|. |
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

AQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILE-ATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKE
....||.    . ...    |||.. |  .  . .|| ..|.     . .. |. .. ..  ....   ||....  .||. . | ..    .... ...
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.....sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

EAANR----DGPMIVHDEHGGVTAGTFCALTTLMHQLEKE---NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQE
.. .      ||..||   |    |||  . .|....||.     .|.... |..   | |.    .||.|.||.|   . |...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2027-2281 6e-43 142.4 In-house 4-253 (284) alignment 
Range on Protein: 2027-2281
Range on HMM: 4-253/284.0
FQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgq
|. ...  .. .| . |  . |..|||   |.. ....| .  | | |..||||||.| || . . .| || ||  |..|||||||..|.  .|..    
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

nmAEDEFVYWPNKDEpINCESFKVTLMAEEHkclSNEekLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKE-----EAANRDGPM
   .    |||.| . |. | ||| . . |    |.|   ...|. |   ..   . ..| |    ||.   | . . .|. ..|      .  |   ..
..kdkcsqywplkiv.ikeerfkvkvdsvee...see..yvvrdielsedgkekdirkirqfhflgwpdvgvpdy.psdlmrlvkkvrhltskenhrani

IVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
.||   |   .|.. .| .|......|. ||||.. . .   |. .  |. ||.|.|  .| 
vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1749-1999 8.5e-43 141.1 In-house 54-295 (305) alignment 
Range on Protein: 1749-1999
Range on HMM: 54-295/305.0
DNKHKNRYINIVAYDHSRVKLAQLAekdgkLTDYINANYVDGYNRP-KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 .. |||| .. . |.| |||.. .      .||| ||||     | | .|.|||||  | ..|| |. ...|| |||. . || |. || |||||   |
iaitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

EygnflVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSG---RVVTQYHYTQWPDMGVPEYSLPVLTFVRkaayAKRHAVGPVVVHCSAGVGRTGTYI
      .. ||  |.   .  .   |...|.    .   ||     | . ..|.||| |||   |  | ..     | | .  |.|||||||.||||| .
k.....lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslells....airgskvpivvhcsagigrtgtiv

VLDSMLQQIQHEGTV-NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETE
 .. .|..|  .  .  .  ..| .| || . .|.. ||.|||  ... .| |  |
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_PTPN23_pd Subfamily PTPN23 2017-2284 3.2e-42 139.3 In-house 11-281 (288) alignment 
Range on Protein: 2017-2284
Range on HMM: 11-281/288.0
PAGKTKLEKQFQLLSQSNI-QQSDYSAALKQCNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYY-QSNEFIITQHPLLHTIKDFWRMIWDHN
. |||.|.|.|..| |..  .. . | |. ... ||||   |.| ...|| .    |.  ||||||.. .   .. .||.|| ||  |. |||.|...  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

AQLVVMIPDGQNMAED-EFVYWPN-KDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PDSPiSKTFELISVIK
....||. . ... .     |||. |.|. . . ..|||  ..     . |. . ....||  . | | .|.| |  .||.   |.|| .. .... ...
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.....etethvervlkletldadavksvshlqltsWpelGvPasP.etllqfldeve

E--EAANR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSV-DVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
.  || .|  . |..||   |   .|.|. . . ...|||.| . |. || . .   |  .  . ||..|.|...|  . 
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_ptpA1_pd Subfamily ptpA1 1746-1955 6.5e-42 138.7 In-house 43-258 (418) alignment 
Range on Protein: 1746-1955
Range on HMM: 43-258/418.0
NHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGyNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD-
..  |  |||| ||.  .|.||.| .. .|.|  .|||||||.||   || .|..||||  |  |||||.||  . .|||..   |. | |||.||| . 
dkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

GSEEY-----GNFLVTQKSVQVLAYY--TVRNFTLRNTKIkkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR------HAVGPVVV
| |..     || ..   ||...       |.   || ..           | .|||.|  |||  .|... |.  ...  .  .           |..|
ggeqfsiygngnevfgtysvelveviqdpereiitrnirl.....tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGVGRTGTYIVLDSMLQQIQH
|||||||||||.     |.....|
hcsagvgrtgtfctavimmkkldh
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2023-2281 2.5e-41 136.6 In-house 7-266 (274) alignment 
Range on Protein: 2023-2281
Range on HMM: 7-266/274.0
LEKQFQLLSQsNIQQSDYSAAlkqCNREKNRTSSIIPVERSRVGISSLSGEG--TDYINASYIMGY-YQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
|||.|  |   | .| ... .    . .|||  .|.| |.||| ..| |.|   ..|||| || || ..|. .. || || .|..||||||. ...|..|
lekeflelPl.nfdqeeldvf...gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MIPDGQNMAE-DEFVYWPNKDEP-INCESFKVTLMAEEhkcLSNEEKLIIQDFILEATQDdyVLEVRHFQCPKWPNPDSPIS--KTFELISVIKE---EA
|. . ... |    ||.|.. .  |. .  .| .  |.     ....  .. ..|. ...    .| |.  ..||. .|| .  . ..|.  ..|   |.
mltklkeaneqkCavyfPdaedyeiserygdveikvek...iverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreee

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
... .|..||   |   .| | | .  ..||..|. ||| ..   . | | |.    |||.......  
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1744-1998 9.2e-41 134.8 In-house 37-276 (288) alignment 
Range on Protein: 1744-1998
Range on HMM: 37-276/288.0
SSNHPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLtdYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
 ... .|  ..|| |.   | .||||      | ..  ||.|| |   . ..  | || ||..| | .|.|. | .|| |||...|.|||..| ..|.| 
idsfianptrdryenlprcditrvkls....ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

DGSE--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgrpsgrVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayakRHAVGPVVVHCSAGVGRTG
   |   .| .    |  ..    .|.  .||..|  . ..       .| . |. .|.| ||||  |. | ..       .    |.|||.||||||||
klGekarigrlctvvkkkradidklvkvsllriskegeekv.......ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtg

TYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
| |.   .|.... .  . |  .|.. | .|   .||| ||...|  . | .| |  
tlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1747-2003 3.2e-40 132.6 In-house 49-299 (310) alignment 
Range on Protein: 1747-2003
Range on HMM: 49-299/310.0
HPDNKHKNRYINIVAYDHSRVKLAQlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG-
. .. ||||| ..|  | |||||        .  ||| ||||      ...| .||||. |  ||||||..   | |... . .|.|| ||  |||. | 
ykkymhknrysdvvcldtsrvklki...dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

SEEYGNFLVTQKSVQVLAyYTVRN--FTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLpvLTFVRKAAYAKRHavGPVVVHCSAGVGRTGTY
.| ||   ||. |      . . |   |.   ..    |     .  |.  .. .|||.|||.      |  ..     ||  ||.|||||||..|... 
tetygcirvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqvrh..gpcvvhcsagkdrlyvv

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVeAILSKETEVLDS
. |.  ......   |..     ... .|   .||| ||..|.   . ..   |||| ..
valklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaek
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1751-1990 7.2e-39 128.5 In-house 48-341 (350) alignment 
Range on Protein: 1751-1990
Range on HMM: 48-341/350.0
KHKNRYINIVAYDHSRVKLA-QLA-----EKDGKLTDYINANYVDGY-----NRPKA-YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
  |||| ||. |.||||||   |      ..  .  |||||||.          |.  |||.|.||.|| .||...| . .|.||...|..|| ...||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPADGSEE--------YGNFLVTQKSVQVLAYYTVRNF----TLRNTKIKKGS-----QKGRPSGRVVTQYHYTQWPDMGV---PEYSLPVLT-----
.||.  . ..        . |   ...|..  |              ....|.       .       || | .. .|.|...   ||  |..|      
rYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndl

--FVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQ------QIQHEG---------TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
        . .     |..||||||||||||.. |||.|.      ....|             |.  ....|.||  .||. .|..||...| 
iddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2024-2287 9.2e-39 128.3 In-house 29-288 (297) alignment 
Range on Protein: 2024-2287
Range on HMM: 29-288/297.0
EKQFQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQsnEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
...|. | ..|||..    | |. | ||.| . |.|...||| . ..  .   ||.|||.. |. .  ..| || |   |..|||.|..|.... .||. 
seeflclpeaniqpq..tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

DGQNMAEDEFVYWPNKDEpINCESFKVTLMAEEHKCLSNEEKLIIQDfileaTQDDYVLEVRHFQCPKWPNPDSPI----SKTFELISVIKEEA-ANRDG
| ..  .    ||..|    .  .  |.|.. ....   . .| ..       .      |. .|  .||. . .     |.  .||| ....   | .|
ddnerdkkcaryWsdkgv.ttfGdvsvvllsvsereGfikrelevtk.....gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
|..||   |   .| ....   . . ..|..||.... |..   || .    |||.|.|...|  ... .
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1729-1986 2.3e-38 126.7 In-house 30-274 (301) alignment 
Range on Protein: 1729-1986
Range on HMM: 30-274/301.0
QEVQSCTVDLGITADSsNHPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLTDyINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITN
..|.  |.|     .| .   .|.|.|| ..    .. |..     .|||    | ||...   .|. .||.|||||.|.|||| |.  ..|| |||...
envnvttidkdhites.yaylpkdkhryptvPckPstavevi....vdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgq

LVEKGRRKCDQYWPADGSEE--YGNFLVTQKSVQVLAYytvRNFTLRNTKIKKGSqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayaKrHAV
 |||  .||..| | . ||.   | | .. |. ...      . . |. ...  .  |. . | || | |..|.| |||.    .  ..  .   | .. 
kvekleekceeylpvkisekldigrfkikiknkeliln...kkiskrtlevedst..gkfatrtvthyqysewtdrgvPkshaelfdlmelv...k.kse

GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
 |.|||||||.||. ..|  . . .... . |...   |||.| .|   |||..|  .. 
kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2021-2280 1e-37 124.6 In-house 6-263 (283) alignment 
Range on Protein: 2021-2280
Range on HMM: 6-263/283.0
TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGegtDYINASYIM---GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
.. . ... | . .. . |   |  . |..|||   |.|... || . |.|    |||||..|.    | |....||.| || .|..|||.|..|...  
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

VVMIPDGQNMAEDE-FVYWPNKDePINCESFKVTLMAEEHKclsneEKLIIQDFILEAT--QDDYVLeVRHFQCPKWP--NPDSPISKTFELISVIKEEA
.||.   |.  . .   |||..   ..   | |||  |  .     . .||. ..|       . .| . |.|   |   .....|     .  ||    
ivmltklqedlrikCsqyWPkrG.sedyGeftvtlrketts.....nsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqt

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 ...||..||   |.  ...|.|... ....  |  |||..| |..   |...    .||.......|
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2039-2283 2.1e-37 123.6 In-house 35-277 (315) alignment 
Range on Protein: 2039-2283
Range on HMM: 35-277/315.0
DYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWP
   .| .. | .|||   |.|....|| .  .  .   |||||||| .. . . .| .| ||  ...|||||......  .||. . |.        |||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

N-KDEPINCESFKVTLMAEEHKCLSNEEKLIIQdfileatQDDYVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTF
. | . ..  |.||.|.  |        ||...       . .    |  ||  .||.  ..      ..||  .| .  ... ...||   |   .| .
drkadsvefGsikvellsleadtdgvarklvtr.......kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvv

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
...   . |.....||||... |..   || .    |.| |.| ..|  .
isidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN9_pd Subfamily PTPN9 2020-2283 2.9e-37 123.3 In-house 15-290 (297) alignment 
Range on Protein: 2020-2283
Range on HMM: 15-290/297.0
KTKLEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
|  | |... . . ...   . |. ...| |||| . .. ....|| ...... | .|||||... || | . || || || .|..|||||.|....  .
krGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMIPDGQNMAEDE-FVYWPNK-DEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEA--
||.    ..       |||.. .. ..  ...|. .  |     .||.  .. . .. ....   .| |||   ||.   | |    ........|.   
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveve.....eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

-----------ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
             .. |..||   |   .|||..|   . .||... ||| .. |..   |       |||.| |. .|   
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2024-2284 2.9e-37 123.3 In-house 18-277 (281) alignment 
Range on Protein: 2024-2284
Range on HMM: 18-277/281.0
EKQFQLLSQSNIQQSDySAALKQCNREKNRTSSIIPVERSRVGISS-LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
 .... |.. .....  .|. .. |..||| | |.  . .|| ..   . . ||||||... || . .|.|.|| |. .....||.|.|.......||. 
ieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

DGQNMAE-DEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILeATQDDYVLEVRHFQCPKWPNPDSPISkTFELIS----VIKEEAANRDG
   .        |||.... ..   ..|. .|||.     ... | . | |  ...    ||....  .||.   | . | ||..    | | .  ... 
reieagklkChrYWPddnselkygdvtvkstaeee.....katyierkfkl.eresgetreveqlaytaWPdhGvPat.tkellefrkevlkltekktka

PMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
|...|   |   .||. || .|....|.| ...|| .| . .   |  .   . ||.|.||..|  ..
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0044763 (Phosphotyrosine protein) phosphatases II 1762-1987 3e-37 123.3 In-house 2-165 (178) alignment 
Range on Protein: 1762-1987
Range on HMM: 2-165/178.0
YDHSRVKLAQLaeKDGKLTDYINANYVDGYnrpkAYIAAQGPlkstaEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSeeygnflvtqksvqv
.|..||.|  |   .   .|||||......     |.....|     .|......|... .||..|. .| |. |||.||| . .               
ldrtrvllsnl..eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

layytvrnftlrntkikkgsqkgrpsgrvvTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQiqhegTVNI
                               ||... .||.|||. .  .| ||.    |     |||.|||||||||.|| .... |...      ...
..............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsl

FGFLKHIRSQRNyLVQTEEQYVFIHD
.  ....|..|.  |....|. ....
eeaielvrerRp.ivpnpgqlrqLye
0041856 (Phosphotyrosine protein) phosphatases II 2048-2282 3.5e-37 123.1 In-house 1-170 (182) alignment 
Range on Protein: 2048-2282
Range on HMM: 1-170/182.0
NREKNRTSSIIPVERSRvgisslsgeGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgqnmaedEFVYWPnkdepincesf
|..|||.| |.|...||         . |||||....|.. ...||.||.|||.|. ||.||..... ...|..         |. |||           
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp...........

kvtlmaeehkclsneekliiqdfileATQDDYVLEVRHFQCPKWPNPDspISKTFELISVIKEeaanRDGPMIVHDEHGGVTAGTFCALTTLMHQleken
                              ...........| .. ||  .......|  ..|    ..|| .||  .|   .||..|.  ....     
..........................ellerlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

SVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
.|..... |... .|||..   .||.||. ..| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN13_pd Subfamily PTPN13 2037-2284 6.1e-37 122.4 In-house 25-270 (273) alignment 
Range on Protein: 2037-2284
Range on HMM: 25-270/273.0
QSD-YSAALKQCNREKNRTSSIIPVERSRVgisSLSGEGTdYINASYIMGYYQSNEF--IITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEF
  |  . . |. |..|||   ..|....||    |..||. |||||.|    . .|.  |..| || .|.||||.|.|. .|....|.   ..  .    
pldtcevgkkkenkdknryrnvlPydetrv...klgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

VYWPNKDE-PINCES-FKVTLMAeehkcLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAANR--DGPMIVHDEHGGV
 |||.. . ..  .. ..|.|.      . . . . .... .. ..   . || |..  |||. . | |.. ||. ...| .  .   ||..||   |  
rywPesknkklkvsnrlevellk.....vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvaevrrlqtdagPivvhcsaGiG

TAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
 .||. .. ...  .|.....|| .. . .   | ||    .|| | ||.|| ...
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2025-2303 7.3e-37 122.2 In-house 27-308 (325) alignment 
Range on Protein: 2025-2303
Range on HMM: 27-308/325.0
KQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPD
..|.||   . .   . .| |  |..|||   ......||| . ..  .. .|||||||.  . . . |. .| || .||.|.||.. | .. .||..  
hefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

GQNMAEDEFVYWPNK-DEPINCESFKVTLMAEEHKclSNeekLIIQDFILEATQDDYVLEVRHFQCPKWP---NPDSPIS--KTFELISVIKEEA---AN
 ..  .   ||||..  .  .  ...| |.. |.   |.    . . . .  ...   . |. ||   |.   ..  | .     .|.  ..|     ..
ldlgkdrcavywpkemgksktfGglevklrtieei..sd...yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALP
  .|..||   |   .|.| .| ... .. .| .||.... | .   || .   ..|| ..|. .   . . . . | .|.... ..| 
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2031-2284 7.8e-37 121.6 In-house 21-278 (287) alignment 
Range on Protein: 2031-2284
Range on HMM: 21-278/287.0
SQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED
  |.     . || .  . .||| . ..|.. .|| .|  .  |.||||| |. .| . ..|| .| |.  |..||||.......  |...    . |  
edsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearl

E-FVYWPNKDEPINCESFKVTLMAEEHKclSNEekLIIQDFILEAT--QD-DYVLEVRHFQCPKWPNPDSPISK-TFELiSV----IKEEAANRDGPMIV
. . |||... |.    . |.|.  . |  . |    .. . |     ..   |  .  ...|.   . . ..   | | .|      .  |.  ||..|
kcykywPerevPmrvGGysvvlldydik..ePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvl.dvkqhielardasevGPlvv

HDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
||. |   .|.. |. .|...||.   ||| .|   .   | ..   . |...||. . .   
hddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0051082 (Phosphotyrosine protein) phosphatases II 1779-1989 2.1e-36 120.1 In-house 2-149 (151) alignment 
Range on Protein: 1779-1989
Range on HMM: 2-149/151.0
LTDYINANYVDGYnrpkaYIAAQGPlkstAEDFWRMIWEHNVEVIVMITNLVEKGrrKCDQYWPADGseeygnflvtqksvqvlayytvrnftlrntkik
|.||||..||.|.     ... .||     .||.....|... .||......| |  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

kgsqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQiqhegtVNIFGFLKHIRSQRNYLVQT
          . |...... ||| |.|..   || |.....    .  |||.||||||.||||| ..|. ||..      |...  |...|..| ..||.
..........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

EEQYVFIHDTL
..|..|..  |
nqqflfqlfal
PTPc_DSPc_SM00012 1891-1990 5e-35 115.2 In-house 2-104 (105) alignment 
Range on Protein: 1891-1990
Range on HMM: 2-104/105.0
VTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAV--GPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD
|..||||.|||.||||.| ..|...|.    |...   .|||||||||||||||...|| .|||...| ..|.|| ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLV
 | 
all
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1744-1907 2.3e-34 113.6 In-house 27-182 (297) alignment 
Range on Protein: 1744-1907
Range on HMM: 27-182/297.0
SSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgklTDYINANYVDGYNRPK--AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYW
|.. .   .|||| .|.|.| .|||| .   .    .|||||.||   . ..   || |||||..| .|||....|..| ||||...| | || ||  ||
sakrnsslrknryrdilatddtrvkllrvite....rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLrnTKIKKgsqkgrPSGRVVTQYHYTQWPDMGVPEY
|    .  . |...|   |     . .|    |  . | .         |||.   .  ||| |||  
psvvqerlkagdvvveflsstsdefdrviltel..qliyr......sesrvvrhvqflswpdhGvpsd
subfamily_PTPN3_pd Subfamily PTPN3 2025-2282 4.3e-34 112.7 In-house 19-274 (280) alignment 
Range on Protein: 2025-2282
Range on HMM: 19-274/280.0
KQFQLLSQSNiQQSDYSAALKQCNREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIM----GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
.||. | . . .. . ||| |  | .|||   |.| .  ||   .|. . ||||||.|.     .  ..| .|.|| || .| .|||.|.|.....|.||
aqfeqlyrkk.pglaisaarkpenlsknryrdilpydatrv...klkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

IPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEehkclSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDG
. .  .        |||.... ..  .|.|..  |     ..... ......|. .. .   .. ..|   ||. . | ..   .|... ...  . .. 
lttlverGrvkChqyWPetedeleygefsvkceke.....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkee

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|..||   |   .| . .| | .. .|....| . .. ...   |  .    .||.|. . || .
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0049772 (Phosphotyrosine protein) phosphatases II 2041-2287 7.5e-34 113.2 In-house 39-284 (314) alignment 
Range on Protein: 2041-2287
Range on HMM: 39-284/314.0
SAALKQCNREKNRTSSIIPVErSRVGISSLSGEGTDYINASYIMGYyqsNEFIITQHPLLHTIKDF----------WRMI--WDHNAQLVVM--------
 .| . .||.|||.  |.|.. .||....|...|.|||||||. |.   . ||.||.|| .|. ||          |||.  .|.|   .||        
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

---------------IPDGQNmaedefvywpNKDEPINCESFKvtlmaeehkclsneekliiqdfilEAT--QDDYVLEVRHFQCPKWPNPDSPISKTF-
               |.||..          |   . . | .|                        | .  ....  .. .. .  .| .. |... | 
elsrLdaAlgKtpllildgng..........neptaadlellk........................eelydpelferlgikylripvpDgsaplledfd

ELISVIKEEaaNRDGPMIVHDEHGGVTAGTFCALTTLMHQLekenSVDVYQVAKMINLMRP-----GVFADIEQYQFLYKVILSLVSTRQ
|.. .|.|   ...|| .||  .|   .|||...  ||..|     |.. .. ... |.||     | .   |||.| ....| .... .
eflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2034-2287 8.2e-34 111.8 In-house 8-268 (270) alignment 
Range on Protein: 2034-2287
Range on HMM: 8-268/270.0
NIQQSDYSAALKqcNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQ-SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
. ..||  .| .  ... ||   |.|  ..|| ...|. .  | |||| |. |. . ....| .. ||  |.|.||||||..... .||. . ..   ..
etsesdlpeaar..gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkk

-FVYWPNKDEP-INCESFKVTLMAEEHKclsNEEKLIIQDFILEaTQDDYVlEVRHFQCPKWPNPDSPISKT-----FELISVIKE-----EAANRDGPM
  .|||.. .  ...|  |.. .|....   .||  |..   || .. .   .. ||.  .||.   | ..       .|......     .  .. .|.
CerYWpaepkekvkledgkikvlalsee...keegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

IVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
.||.  |   .||. || . .. ||....||| .. . .   |. .    |||.||||...  ...|.
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2043-2284 9.7e-34 111.3 In-house 38-277 (515) alignment 
Range on Protein: 2043-2284
Range on HMM: 38-277/515.0
ALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPNK-D
| .. | .|||   |.| ...|| .  .  .   ||.||||| ..   . .| .| |.  ...||||.....|   ..|. . ..        |||.|  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

EPINCESFKVTLMAeehkcLSNEEKLIIQDFILeaTQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIK---EEAANRDGPMIVHDEHGGVTAGTFCAL
. ..  |.|| |..     |.     |.. . .  ...| .  |  |.  .||.  .|   |  |. .||    .  .   |.|.|   |   .| ....
dsvkfGsikvelvs.....leactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisi

TTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
   . . .. ..|||... . |   || .    ||| |.| ..|  . 
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_CG42327_pd Subfamily CG42327 1745-1915 2.4e-33 110.2 In-house 23-187 (319) alignment 
Range on Protein: 1745-1915
Range on HMM: 23-187/319.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
   .  | |.|.||.|   ..|| | . ...|   . |..|.|| ||.  |  ||||| .|.... ||||..|| .  ||| .|.| |.| ..| .|.|.
evPvtskdksrvinvvPlPetrvvlqrigdddk..deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

----DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkGSqkgrpSGRVVTQYHYtQWPDMGVPEYSLPVLTFV
    |. . ||..||| |  .|   | .  . |.. .   ..       | .| | | .|.. .||    .... .
ketldntslyGdilvtlkgrevkdryaistlllkrvd...ke.....esrelthywy.kwleaevPaeeaaliaml
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2020-2285 2.7e-33 109.9 In-house 14-295 (301) alignment 
Range on Protein: 2020-2285
Range on HMM: 14-295/301.0
KTKLEKQFQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISS---LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
..|.|.|.. |.. . ...  .  |.. |.. ||  .| ...  |. ..    |.   ..||||||| || ....||..| |. .|..||||.||..  .
snkfeeqykelkegedksc..tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

LVVMIPDGQNM-AEDEFVYWPN-KDEPINCESFKVTLMAEEH--KCLSN----------EEKLIIQDFILEATQddYVLEVRHFQCPKWPNPDS---PIS
 .||. . ..   .  . |||| . |  .   |.|||. |      .            ... |.. |  ....     .|  .|  .||.      |  
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
    .  ||. .     ||..||   .   .|..|...  . |   |  |||.|| | .   .||.   .||| ..|.||   .. 
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_PTPN14_pd Subfamily PTPN14 2036-2283 4.7e-32 106.2 In-house 37-296 (300) alignment 
Range on Protein: 2036-2283
Range on HMM: 37-296/300.0
QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ--SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEF
.....|.|  . | ||||.  ..| | .|| .|.   . |.||||| |       . ..|..| || .|..|||.|.|... ||.||. .  ..  |  |
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

VYWPNK---DEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS------KTFELISVIKEEA-----ANRDGP
 |.|..    . .. . ||||    |     . ...| . . |.        .| |.|   ||. . |           |. || ..        ... |
kyfPkleskkktvefgkfkvttkfse.....dsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
..||   |.  .|       |.. ||.....|. .| ...   |  . . . ||.|.|||..  .
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN1_pd Subfamily PTPN1 2034-2281 2.8e-31 103.3 In-house 18-269 (290) alignment 
Range on Protein: 2034-2281
Range on HMM: 18-269/290.0
NIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSlsgEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEF
. .. . ..| .. ||..||   . | . ||. . .   . .|||||| .       ..|.|| || .|.. ||.|.|..... |||.    .      .
easdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

VYWPNKDE--PINCE--SFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PDSPISKTFELISVIKEEAANRD-GPMIVHDE
 |||...|   . .|  ..||.|..||.|     .. ... . ||  . .   |. ||   .||.   |.|| .    |  | .  . ..| || ..|  
qywPqgeeekellledtklkvkliseerk.....syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

HGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 |   .|||| . |.. ..||..    ||. .|   .  .| |.    .| .| |  || 
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0036282 (Phosphotyrosine protein) phosphatases II 2074-2277 2.5e-30 100.8 In-house 1-164 (174) alignment 
Range on Protein: 2074-2277
Range on HMM: 1-164/174.0
GTDYINASYIMGYYQSNEFIITQHPLLhtikdFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNkdepincesfkvtlmaeehkclsneekliiqdfil
|.||||||.. ..| ....|..|.||      ||.|..... . |||  . . .  .  . |||                                    
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

eaTQDDYVLEVRHFQCPKWPNPDSP-ISKTFELISVIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEkENSVDVYQVAKMINLMRPGVFADIE
  ...|.. .. ....  ||    | .|. .|... ..|  .. ..||..||  .|   .||..|.  ....|. |. ||.... ... |.|||..   .
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYQFLYK
||.|||.
Qyrflyy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1888-2034 5.7e-30 99.0 In-house 88-236 (440) alignment 
Range on Protein: 1888-2034
Range on HMM: 88-236/440.0
GRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
 |.. ||||  ||| |||... ||| ...    .. . . ||..||||||.||||  |..||.|.. ..   ..|| |.. .|..|  .||| |||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DTLVEAILSKETEVLDSHIHAYVNALLIPGPA-GKTKLEKQFQLLSQSN
....|..|. .| .|.  |   |. .  | |   |. |...|.  |. |
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskkn
subfamily_PTPRN_pd Subfamily PTPRN 2019-2280 2.6e-29 96.9 In-house 27-289 (297) alignment 
Range on Protein: 2019-2280
Range on HMM: 27-289/297.0
GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYY-QSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |..|||... | . . ..|  ..| .. | .|||.....| . ||| ... .  | .|||||| |.    ..  .| || || .|. |||.|.|.. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

LVVMIPDGQN-MAEDEFVYWPNKDEPINcESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAA
..|..   ..   . .  |||.. . .  . ..| |..|   |    .  ... | |   | .    |  |    ||. . | |    .|.   .     
vivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwc....ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 |  |..||  .|   .|.....  ....| |  . .|.    . .   |||. .  .|..| .... 
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2020-2280 2.6e-29 97.1 In-house 5-256 (267) alignment 
Range on Protein: 2020-2280
Range on HMM: 5-256/267.0
KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEgtdYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
....||.|.|. .   ..|  |  . . |.|.||    .| . .|| ..    |   ||||||. ||.. | ||.|| ||  || ||. .| |..   .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MIpdgQNMAEDE-FVYWPNKdepiNCESFKVTLMAEEHKCLSNEEKLIIQDFILEAtQDDYVLEVRHFQCPKWPN--PDSPISKTFELIsVIKEEAANRD
..   ..  .|.   .|| |      .. |   .. ||    .|.   |  . |.  ...   .|  .   ||     . |  | .  | . |..  | .
ll...tkvftdnirlfwPPk....mgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgi.laknqlengn

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 |..|. . |  ..|||  . . .... .|. .|...  . |   |.|.    |.| ...... 
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_egg_pd Subfamily egg 1744-1990 4.8e-29 96.0 In-house 34-267 (307) alignment 
Range on Protein: 1744-1990
Range on HMM: 34-267/307.0
SSNHPDNKHKNRYINIVAYDHSRVKLaQLAeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrRKCDQYWPA
 .   .|..| |   .   | ||||| .|  .   | |.| ||.|.|      .| || ||| | .|||||... .|. |||.|  .|    .|. ||| 
taasdnnlekarskrvhckdssrvkl.elr.rGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

DGSEEYgNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQ--KgrPSGRVVTQYhYTQWPDMGVPEYSlpvLTFVRKAayakRHAVGPVVVHCSAGVGRTG
  |.    ..     .. |  .   .  .| ||.|      .     | .  .   ..  ..   .    |  .||.    |..  ||||..  || ...
aesdsl.vtvpGslrienlkvdskadplfrvtklkl..vGgd..deerflehw.qgdvnnssdvysp...lrvlrkl....rnlskpvvvqdilGvskaa

TYIVLDSMLQQIQHEGTV--NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
| . ..  | ..    ..   .    . .| .|.. |..  .|.|..  ..
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1750-1997 6.1e-29 95.7 In-house 43-280 (312) alignment 
Range on Protein: 1750-1997
Range on HMM: 43-280/312.0
NKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA-DGSEE
 |  ||| ||  .|  |  ||      |    || ||.|    .|. ....||||..|.  ||..        |.... .|| |  || .|     |  .
fkdlnrypniqcwdrgrftla......gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

YGNFLVTQKSVQVLAY--YTVRNFTLRNTKIkkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLpvlTFVRKAAYAKrHAVGPVVVHCSAGVGRTGTYIVL
  .  |  ...  .     .  . | |  |.     |       . .| .. ||| |.|.      |  |  .  | .   ||. ||||||||||| ...
ledhrvyteycteieiggkskdkithrvlkv...vvkatgqesklnhyqwaswpdhgmpdscd...talrllsavk.kdkkpviahcsagvgrtgtlali

DSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||.  ..|    |.   .  .| .|   |..  |||.   ...| . || 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
0051429 (Phosphotyrosine protein) phosphatases II 2074-2286 8.7e-28 93.1 In-house 3-228 (272) alignment 
Range on Protein: 2074-2286
Range on HMM: 3-228/272.0
GTDYINASYIMGYYQ---SNEFIITQHPLLHTIKDFWRMiWDHNAQLVVMIPDGQNMAEDE-FVYWP-----------NKDEPINCESFKVTLMAEEHKC
 ..||||... ||..    . .. ...|| .|..||||. ....   .|.. .   .. .  . |||           . ...|.   . |||. ||.. 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LsneekLIIQDFILEAT-QDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEeaanrDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVD-------
       |.  ..|. . . . ..||.|...  ||    | .   ||.... .     .||..||  .|    ||..||  |......|  ||       
d.....yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
 .... ...  .|||.. . |||.|||...| |. . 
yleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2037-2281 1.7e-27 91.0 In-house 37-277 (439) alignment 
Range on Protein: 2037-2281
Range on HMM: 37-277/439.0
QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdgQNMAeDEFVYW
. . | | .. .. |||  .. . . .|| .  . |   . |||| || |||. . .| || |  .| .||||.......  .||.    |.  . . ||
aciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml...tnlv.esykyw

PNKDEPINCEsfkVTLMAEEHKCLSNeekLIIQDFILEATQDDY--VLEVRHFQCPKWPNPDSPI--SKTFELISVIKEEA-ANRDGPMIVHDEHGGVTA
| ..| .  .   ... ..    | |    .|. | .   .|       | .|.   ||. . |   |   ...  |.     .  ||..||   |  ..
psdaevcygd...iavrvdrnielpn...yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
||  ||   . ||  || ||.  . |..   |  .  .. || |.|. .| 
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2027-2282 1.8e-27 90.8 In-house 26-235 (392) alignment 
Range on Protein: 2027-2282
Range on HMM: 26-235/392.0
FQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQ
|. | . .| .   ..| |. | .|||   |.| ...|| .  .     .||.||||| .. . . .| .| |   ...|||||....|.  ..|. . .
fhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

NMAedefvywpnkdepincesfkvtlmaeehkclsneekliiqdfileatQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAANR---DGPMIVH
.                                                 . | .  |  |.  .||. | |  .|  |. .|||  |.      |.|.|
egd...............................................kgddartvaqfhftewPdkdvp.khtssllkfikevkadfGqythpliih

DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
   |   .|   .. ... . .|   |||...   |   || .    ||| |.|  .|  
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1800-1998 5.1e-27 89.1 In-house 96-293 (302) alignment 
Range on Protein: 1800-1998
Range on HMM: 96-293/302.0
AQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQV-LAYYTV-RNFTLRNTKIKKGSQKGrPSGRVVTQYH
   | ||| | .| .| ..|| ..| ....||.. .|| .|.  .  |  ..|.. |. .||.  |. .|  ..|.| . .||   .|     . |   .
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdila

YTQWPDMGVPEYSLPVLTFVRKAAYAKRHavgpVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
.. ||| | |. . . |  ..     |.     |.|||||||||||| . .   .|  ... . ..   .. .|. |   ||.|.| ...   .  ... 
fsawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

KET
|..
kag
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1749-1995 8.2e-27 88.9 In-house 34-272 (285) alignment 
Range on Protein: 1749-1995
Range on HMM: 34-272/285.0
DNKHKNRYINIVAYDHSRVKLAQlaeKDgklTDYINANYVDGYNRP-KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 |   ||| .. . . .|| | .   .|    ||| |...    .   .||..||||  |  |||.||.. ..  ..|.  |.| |  ||  |.|    |
anpdlnryadvrcieetrvvlkn...hd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--EYGNFLVTQKSVQVLAY--YTVRNFTLRNTKikKGSQkgRPsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKrHAVGPVVVHCSAGVGRTGTY
  ..|.. .|   ..  |     . ..|. ||.    |    |    . . .   |||   || . |.. . .     .     |..|||||||||| |.
vvkfgkyeitlteckeeaiagtilnaltvinte..dass..ep..lymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrtatf

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
. .|    .|  .  ....  .. .|. |   ||.  |..|..  |.| .. 
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
0043147 (Phosphotyrosine protein) phosphatases II 2073-2276 6e-26 86.6 In-house 3-154 (172) alignment 
Range on Protein: 2073-2276
Range on HMM: 3-154/172.0
EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGqnmaedefvywpnkdepincesfkvtlmaeehkclsneekliiqdfil
||.|||||||. .||  ..||.|| || .|. |||||..... ...|.. .                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

EATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE--AANRDGPMIVHDEHGGVTAGTFCALTTLMhqlekeNSVDVYQVAKMINLMRPGVFADIE
. . .... .. ....  ||  . |... .. .  . .|  | ...||..||  .|   .||..|.  ..       ....... ...  .|||..   .
lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYQFLY
||.|||
qyrfly
subfamily_ptpA1_pd Subfamily ptpA1 2022-2245 4.2e-25 83.3 In-house 22-258 (418) alignment 
Range on Protein: 2022-2245
Range on HMM: 22-258/418.0
KLEKQFQLLSQSnIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQsNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
|....|.|| .| .  |. |   |. |  ||| . |.||...|| .  .   ||.||||| || | |  ..|| || ||  || |||||.|.  ....||
kikeefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivm

IP-DGQNMAEDEFVYWPNKdepINCESFKVTL---------MAEEHKCLSNEEKLIIQDFIlEATQDDYVLEVRHFQCPKWPNPDSPIS-KTF-ELISVI
.  . .|       |||..   |  | | .             |  . . . |. ||   |   | .    .. ..|   ||. . |   . | .|.  |
lsresencrikcdrywpeq...iggeqfsiygngnevfgtysvelveviqdpereiitrni.rltfegetrditqyqyegwpdhnipdhtqpfrqllhsi

KE------EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEK
 .       ...|. |.|||   |   .||||.   .|..|..
tnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
0048076 (Phosphotyrosine protein) phosphatases II 1867-1988 7.8e-25 82.6 In-house 33-138 (145) alignment 
Range on Protein: 1867-1988
Range on HMM: 33-138/145.0
VRNFtlrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDSMLQqiqhEGtVNIFGFLK
| |.          .   .   | ..||.|. |||.|||. .  .|.|..    | ..  |||.||||||||||||..... ||.    .| |...  |.
vlnl..........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeale

HIRSQRNYLVQTEEQYVFIHDT
..|||| . |....|. |... 
lvrsqrpgavpnpgqlrflyef
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2048-2280 9.1e-25 82.2 In-house 3-236 (237) alignment 
Range on Protein: 2048-2280
Range on HMM: 3-236/237.0
NREKNRTSSIIPVERSRVGISSlSGEGTDYINASYIMGYYQS-NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPNKDEPINCE
|. ||| ..|.  . ||| .   .| |.|||||.|. |.  . ...| .| ||  . .|||.|.|. .  ..||.    .  |     |||. |.|    
nkiknrygnivaydhsrvvlkg.agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SFKVTLMAEEHKCLSNEEKLIIQDfilEATQDdYVLEVRHFQCPKWPNPDSPISKTFELI---SVIKEEAA-NRDGPMIVHDEHGGVTAGTFCALTTLMH
 . |.|  .|. .      |...    . |.   |  .  .|   ||.   |   .  |     .|..    .. || |.|   |   .| |  . ....
vltvslkkkeefsdytvrslllsk...rltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
| .... ||.|.  . |.  || .    .|| |....||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0048179 (Phosphotyrosine protein) phosphatases II 1884-1987 5.8e-24 79.9 In-house 48-139 (144) alignment 
Range on Protein: 1884-1987
Range on HMM: 48-139/144.0
GrpsgrvVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDSMLqqiqHEGtVNIFGFLKHIRSQRNYLVQTEEQYV
       ..||... |||.|||...  .|.|..    | ..  |||.||||||||||||..... |.    ..| ....  |...||.| . |....|. 
e......giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlr

FIHD
|...
fLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1795-1986 1.2e-23 78.3 In-house 5-197 (199) alignment 
Range on Protein: 1795-1986
Range on HMM: 5-197/199.0
KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqKGRPSGRVVT
. |||.| ||. |  |||.|.||     |||. .   .       |||.   |. .||.. || |.. . . ||.  . | |           || | ..
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt......tappstreis

QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE--GTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
.| .| | .   |. .| |   |     .|..      ||.|||| | | || .. ||  ..  .      |..|   | .|  |  .. . ..| ||.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1795-1986 1.2e-23 78.3 In-house 4-196 (198) alignment 
Range on Protein: 1795-1986
Range on HMM: 4-196/198.0
KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqKGRPSGRVVT
. |||.| ||. |  |||.|.||     |||. .   .       |||.   |. .||.. || |.. . . ||.  . | |           || | ..
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt......tappstreis

QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE--GTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
.| .| | .   |. .| |   |     .|..      ||.|||| | | || .. ||  ..  .      |..|   | .|  |  .. . ..| ||.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0046846 (Phosphotyrosine protein) phosphatases II 2072-2281 1.5e-23 78.9 In-house 9-171 (176) alignment 
Range on Protein: 2072-2281
Range on HMM: 9-171/176.0
GEGTDYINASYIMGYYqsneFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCesfkvtlmaeehkclsneekliiqdfi
... |||||..|.|..    .|.||.|| .|. ||..|..... ..||.. . . ..   . ....  |  ..                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

leatqddyvlevrHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTtlmhQLEKENSVDVYQVAKMINLMRP-GVFADIE
             ....  ||  . | .. .. .  . .|| ...|| .||  .|   .||..|.      ||.|. ..|... ...  .|| |..   |
.............qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYQFLYKVILS
||.|||...| 
Qyrflyefell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2042-2280 3.8e-23 76.9 In-house 2-238 (239) alignment 
Range on Protein: 2042-2280
Range on HMM: 2-238/239.0
AALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSN-EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEFVYWPNK
|| |. |. ||| . |.  ..||| .  || .  .|||||||.  |  |   .| ||  .  .  |||||.|.    ..||.    .   .  . |||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEpINCeSFKVTLMAEEHKClsneeKLIIQDFILEA---TQDDYVLEvrhFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
     |  ..|||   |  .       ||. |..     |.. || .   ..   ||.   |   |  . |   | ...     | ..|   |   .|.|
ts.kyc.nlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
  . ....| .|...||...  | |   || .    ||| |..  .|
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2042-2280 5e-23 76.5 In-house 1-237 (239) alignment 
Range on Protein: 2042-2280
Range on HMM: 1-237/239.0
AALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSN-EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEFVYWPNK
|| |. |. ||| . |.  ..||| .  || .  .|||||||.  |  |   .| ||  .  .  |||||.|.    ..||.    .   .  . |||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEpINCeSFKVTLMAEEHKClsneeKLIIQDFILEA---TQDDYVLEvrhFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
     |  ..|||   |  .       ||. |..     |.. || .   ..   ||.   |   |  . |   | ...     | ..|   |   .|.|
ts.kyc.nlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
  . ....| .|...||...  | |   || .    ||| |..  .|
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1724-1997 9.7e-23 75.0 In-house 28-289 (302) alignment 
Range on Protein: 1724-1997
Range on HMM: 28-289/302.0
LKEFYQEVQSCTVDLGItadSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVDGYNRPKAYIAAQGPLKSTA---EDFWRMIWEHNV
.|. ......  |||      . . .| .||.  .. ..|. .|||.. ..      .|.||  |.  .  .  | || | ....   |.||||......
vkkefkkidtmkvdlek...Ckafkknlkknqsedvpildsnlvkleaepd......syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

EVIVMITNLVEKGRrKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTvRNFTLRNtkIKkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
  .|..    |  .   ....|  ..  .|||.. | .. |.     .  ....    .     .|     ... |. |.|..  ||.    . . . | 
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEv..lP....egcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
   | .|  ..|.    |.|| |. ..|   ....|..  .||   .| |||||   |.. .|||... .|.  |. | 
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_egg_pd Subfamily egg 2023-2281 2e-22 74.3 In-house 16-268 (307) alignment 
Range on Protein: 2023-2281
Range on HMM: 16-268/307.0
LEKQFQLLSQSnIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI
||.....| .| ...  .  |... |.|| |.  .   . ||| .    |    |.| | .. |    ||||..| ||  | .|||||..  . | .||.
lerrlevlees.vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

PDGQNMAEDEFvYWPNK-DEPINC--ESFKVTLMAEEHKClsnEEKLIIQDFILeATQDDYVLEVRHFQCpKWPNpDSPISKTFElisVIKeEAANRDGP
   ..  . |. |||.  ....     |.... .  ..|    .  . .  . |    ||  . . |.|   . |  | .   ..   |..  . |   |
tsrkesercey.ywpkaesdslvtvpGslrienlkvdska...dplfrvtklkl.vGgddeerflehwqg.dvnn.ssdvysplr...vlr.klrnlskp

MIVHDEHGGVTAGTFCALTT-LMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
..|.|  |   |.|. |. . |.. |        | .  ... | |.     . .| |.|...| 
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2018-2292 2.2e-22 74.0 In-house 24-297 (310) alignment 
Range on Protein: 2018-2292
Range on HMM: 24-297/310.0
AGKTKLEKQFQLLSQSNIQQSDYSAaLKQcNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
 |   | ||.. |   . .   | |  |. .  ||| | ..  . ||| .        ||| | |.   |  . || .| || ||| ||||||..  |. 
lgieglvkqyrkldakqdssltyea.ykk.ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraes

VVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHK--CLSNEEKLIIQDFILEATQDDYV--LEVRHFQCPKWPNPDSPISKTFELISviKEEA
....    .        |||           .|| ..|  .   . |    .. | .    |   .  | |   . |.||.   |  |   .    .  |
illlckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq..rlla

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAkmINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPS
  | || .||   |    .. .||   ...|.. . ||. .|    .|..  .     . |.|.   . .. .| |.. .
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevk..tellksraiciqtelqyliidrvriifargeteva
0044763 (Phosphotyrosine protein) phosphatases II 2060-2283 3e-22 74.5 In-house 2-171 (178) alignment 
Range on Protein: 2060-2283
Range on HMM: 2-171/178.0
VERSRVGISSLSG-EGTDYINASYIMGYyqsneFIITQHPLlhtiKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNKDEpincesfkvtlmaeehk
..|.|| .|.|.| |..||||||.|...     ......|      |......... ...|.. . . .  .... ||| . .                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

clsneekliiqdfileatqddyvLEVRHFQCPKWPNPDsPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQlekenSVDVYQVAKM
                       ....|. .| ...||  .. ..|..  |.|  ....|| .||  .|   .||..|.  ....     ....... ..
.......................iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

INLMRPgVFADIEQYQFLYKVILSLV
.  .|| ..   .|...||.. | | 
vrerRp.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1748-1996 9.6e-22 72.0 In-house 45-282 (303) alignment 
Range on Protein: 1748-1996
Range on HMM: 45-282/303.0
PDNKHKNRYINIVAYDHSRVKLAQlaekdgklTDYINANYVDgYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADgsE
 .| .|||.....  |||.|||..        . || |.|..  .  |  | .| ||  || |||.|| | .| .....    |  .   |  .| .  .
vknmdknrfvdvicldhskvklsd........ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn..q

EYGNFlvTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPsgRVVTQYHYTQWPDMGVPEYSLPV--LTFVRKAAYAKRHA-VGPVVVHCSAGVGRTGTYI
.. .|   ..|..|  .  |      . |.   |.        .  .|| .||   .|  . |       .  .. ....   | |    .|.||.||. 
dflkf..eersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfa

VLDSMLQQIQH-EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
....    ..  . ....   |. .|  | . ||   |. ...  | | .| .
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
0049260 (Phosphotyrosine protein) phosphatases II 2082-2277 1.4e-21 72.2 In-house 1-144 (152) alignment 
Range on Protein: 2082-2277
Range on HMM: 1-144/152.0
YIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWpnkdepincesfkvtlmaeehkclsneekliiqdfileatqddyv
.| ||....|||.||.|. .|..|||||....... .||. . . .... .  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

lEVRHFQCPKWPNPDSPISKTFeLISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMhqlekeNSVDVYQVAKMINLMRPGVFADIEQYQFLYK
 .. |...|  . ||...   | |. .|.. | ...|| .||  .|   .||..|.  ..      . |..... ...  .|||..   .|..|||.
.qylhlpwpDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2091-2278 1.4e-21 71.6 In-house 6-199 (199) alignment 
Range on Protein: 2091-2278
Range on HMM: 6-199/199.0
EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEpincESFKVTLMAEEHKCLSNEEKLIIQDFILE--ATQDDYVLEVRHFQ
 .| ||||| .|. |||.|.|.  .  .||. | |.  | |  .|||  .      . | . ..   |... .    |  .||   .|      |. |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishyq

CPKWPNPDSPISKTFELIS-----VIKEEAANRDGPMIVHDEHGGVTAGTFCALTTL--MHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV
   | .  .|    |  .      | |    ..| |.|||   |   .| | ||      |.  |   ||...||| .   | |. . ...|.|.|.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2091-2278 1.4e-21 71.6 In-house 5-198 (198) alignment 
Range on Protein: 2091-2278
Range on HMM: 5-198/198.0
EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEpincESFKVTLMAEEHKCLSNEEKLIIQDFILE--ATQDDYVLEVRHFQ
 .| ||||| .|. |||.|.|.  .  .||. | |.  | |  .|||  .      . | . ..   |... .    |  .||   .|      |. |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishyq

CPKWPNPDSPISKTFELIS-----VIKEEAANRDGPMIVHDEHGGVTAGTFCALTTL--MHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV
   | .  .|    |  .      | |    ..| |.|||   |   .| | ||      |.  |   ||...||| .   | |. . ...|.|.|.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
0051082 (Phosphotyrosine protein) phosphatases II 2074-2279 2.6e-21 71.2 In-house 2-149 (151) alignment 
Range on Protein: 2074-2279
Range on HMM: 2-149/151.0
GTDYINASYIMGYyqsneFIITQHPllhtIKDFWRMIWDHNAQLVVMIPDGQNMAeDEFVYWPNKDepincesfkvtlmaeehkclsneekliiqdfile
 .||||.||. |.     ......|      ||........ . .|.. . . ..  .  |.|. .                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg..................................

atqddyvLEVRHFQCPKWPNPDSPISkTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQlekensVDVYQVAKMINLMRPGVFADIEQYQ
       .||.|.... ||.|. |.| . ........ .....||..||  .|    ||..||  ....      |..... ... |.||||.   .|..
.......ievlhipildwpdpglpls.fdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FLYKVI
|.....
fqlfal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2019-2288 1e-20 68.9 In-house 14-282 (307) alignment 
Range on Protein: 2019-2288
Range on HMM: 14-282/307.0
GKTKLEKQFQLLSQSNIQQSDYSAalKQCNREKNRTSSIIPVERSRVgISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
| ..|  .|. |.. . .     |   ..| .||| . .  ....|. .  ..|  .||| | |.    . . || .| ||  |. .|| |. ... . |
gvqalvdefrvlakktpegvtvea..fsantdknryqdvkcqdkgri.vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMIPDGQNMAEDE-FVYWPNKDEPINC---ESFKVTLMAEEHKCLSNEEKLIiQDFILEATQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKEEAAN
.|. .  ..|.     ||| ..   .    ..  ...     | |. .|.|| .   |.    .    ..|.|  .||.   |    .  | ...    .
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgvpqi.nltainlleavryd

rDGPMIVHDEHGGVTAGTFCALTTLMHQ-LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQE
   |..||   |   .||  |.. .. . .. .|  |. .. . .   |.    .  || .|..|.|.    .  
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
PTPc_DSPc_SM00012 2183-2280 2.5e-20 68.0 In-house 2-104 (105) alignment 
Range on Protein: 2183-2280
Range on HMM: 2-104/105.0
VRHFQCPKWPNPDSPI--SKTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYK
|.|.....||.   |   .. .||.  .|..  ...  .|..||. .|   .|||.|| .|..||||| ..||..|. |..  .|||..   |||.|||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VIL
..|
all
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1799-1991 3.4e-20 67.2 In-house 39-219 (255) alignment 
Range on Protein: 1799-1991
Range on HMM: 39-219/255.0
AaqgplksTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYgnfLVtqKSVQVLAYYTVRNFTLRNTKIKKGSQKgRPSGRVVTQYHYTQ
        | . |...|   . ||.||.... |.|. ||..|.| .  |      .  . |.| .  .. .  ||  .|     . .   . |. |.|. 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl...kl..advnvtttkssadvvlrtleitstlge.kkkthtvkhysykG

WPDMGVPEYSLPVLTFVRKAAYAKrhavgPVVVHCSAGVGRTGTYIVLDSMLQ----QIQHEGTVNI--FGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|..   || .  .|  .. .  .|     .||||||.|.||. .... ... |    ...   ||..    .|...||.|.  ..|  |  |   ....
WieknaPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1752-1843 2.8e-19 63.6 In-house 50-155 (349) alignment 
Range on Protein: 1752-1843
Range on HMM: 50-155/349.0
HKNRYINIVAYDHSRVKLAQL------------AEKDGKLTDYINANYVD--GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKC
 |||| .|. |.|||||| .               . ||| |||||||.    ..  | ||| | || || .||...|   .|.... ...  |.. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPA
|.||  
diywqe
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2038-2282 7.8e-18 59.1 In-house 26-268 (281) alignment 
Range on Protein: 2038-2282
Range on HMM: 26-268/281.0
SDYSAALKQ-CNREKNRTSSIIPVERSRVGISS--LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FV
||  ....|  | .||| . |  .. ||| .       . |||| | ||   .    .|.|| |   |  |||||||. |.  .||. .  .   ..   
sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPNKDEpiNCESFKVTLMAEEHKCLsnEEKLIIQDFILEatQDDYVLEVRHFQCPKWPNPDSPISKtfELISVIKEEAANRDGPMIVHDEHGGVTAGTF
|.| .     |  |    .. |   .  .. |.   . |    .     . |.   .||. . | |   |..  |  .   |  | ..|   |   .||.
yfprnah..cclqfdklsvsyedstv..nkslvttrlnls..yegetrlithwlwkewpdwqvpess..evmlkilrkirarstppvihcsagvgrsgtl

CALTTLMHQLEKENS-VDVYQVAKMINL-MRPGVFADIEQYQFLYKVILSL
 |.   .. .    .  |. |.   . .  |      ..|| ...||.| .
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_eak_pd Subfamily eak 1747-2011 1.2e-17 58.3 In-house 49-325 (332) alignment 
Range on Protein: 1747-2011
Range on HMM: 49-325/332.0
HPDNKHKNrYINIVAYDHSRVKLAQLAEkdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS
  .. ..|  ..|| ||.  |.|.           ||||  ..  .  . || .  . ..    ||.|. | .   ||.. . ||..  | |.|.| .. 
rleavnrn.vvkivpydrylvrltssql...nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

E--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQ--------YHYTQWPDMGVPEYSLPVLTFVRKAaYAKRHAVGP---VVVHC
|  ..| . |..|.    . . .|.. |.     .  .. .  |   |.          .    ..||.    .  . ..   . | .   |    .. .
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsst.lkkyihtppsfapiiqs

SAGVGRTGTYIVLDSMLQQIQHEG--TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV--LDSHIHAYVNA
. |  |.|...|.| ... |.     .  .  ..  ..|.|.. | .. |. ||.. ... .| .. ..  |. .. || ..
arGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleayaes
subfamily_hpo-7_pd Subfamily hpo-7 1799-1989 1.7e-17 58.2 In-house 42-223 (263) alignment 
Range on Protein: 1799-1989
Range on HMM: 42-223/263.0
AaqgpLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVlayytvrNFTLRNTKIKKGSQKgRPSGRVVTQYHY
     |  | . |...|   . ||.||...  |.|. ||..|.|   |.   . |  |.   ||        .  |.  .. .  .. .   . |..| |
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.......dvllktlellstlge.Kkkthtvkhysy

TQWPDMGVPEYSLPVLTFVRKAAYAKrhavgPVVVHCSAGVGRTGTYIVLDSMLQ----QIQHEGTVNI--FGFLKHIRSQRNYLVQTEEQYVFIHDTL
. |..   || .  .|  .. |   |     ..|||||.|.||.  . | ... |    ...   ||..    .|...||.|.  ..|  |  |   ..
kgWiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1780-1990 3.5e-17 57.5 In-house 46-256 (290) alignment 
Range on Protein: 1780-1990
Range on HMM: 46-256/290.0
TDYINANYVDgYNRPKAYIAAQGPLK-------STAEDFWRMIWEHNVEVIVMITNLVEKGRR----KCDQYWPADGSEEygnFLVTQKSVQVLAYYTVR
 ||| ||.|  .    . |. | |..       || |.|| |. . .|. .||. .  || .      | .| |    ||     .   .|.     .. 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee...lkfkgltvkCkskeked

NFTLRNTKIKKGSQKGrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAyakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ-HEGTVNIFGFLKH
..  |.  .| . ..       || . . .| .. |.| .. .|. ..|          ||.|||  |. |  .   ..   | |   .| |..   || 
dvetRelvvkfddeee....ftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

IRSQRNYLVQTEEQYVFIHDTLV
.|.||. ........ |.   .|
lrkqralaitsalelafvdagiv
subfamily_CG42327_pd Subfamily CG42327 2035-2207 5.3e-17 56.5 In-house 18-186 (319) alignment 
Range on Protein: 2035-2207
Range on HMM: 18-186/319.0
IQQSDysaALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQS-NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDE
| ..|   ..    ..|.|   ..|.  .||   . .  . . |..|||. || .. | .| .| .|  .  ||||..|. ... .| . | ..   .  
iarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvc

FVYWPNKDEPINCESFKVTLMAEEHKclSNEEKLIIQDFILEATQDDYVLEVRHFQCpKWPNPDSPISKTfELISV
  |.| |.   | ...   |..  ..    ... .|  ..|   ...   |. |.   ||.. . | ...  ||..
aeylPtketldntslyGdilvtlkgr..evkdryaistlllkrvdkeesrelthywy.kwleaevPaeea.aliam
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1930-1993 1e-16 55.0 In-house 2-65 (69) alignment 
Range on Protein: 1930-1993
Range on HMM: 2-65/69.0
VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|||||.| |||||.| .   . .|. |  |.||  ....|  |  .|  | .|.||||.||||.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2046-2278 2.4e-16 54.3 In-house 48-273 (301) alignment 
Range on Protein: 2046-2278
Range on HMM: 48-273/301.0
QCNREKNRTSSIiPVERSrVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPN-KDEPIN
  ...|.|  .. | . |   .  ..      | | .|    ... ||.|| ||  | .||| |.  .. . .||.    .  |.    | |    | ..
ylpkdkhryptv.PckPs.tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

CESFKVTLMAEEHKClsnEEKLIIQDFILE-ATQDDYVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEEaanrDGPMIVHDEHGGVTAGTFCALTTLM
 . ||...  .|.     ..|.. . . .| .|..     | |.|  .|.. . | |  ..|.|. ..|.     . |..||   |   . .| .   | 
igrfkikiknkelil...nkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteyla

HQLEKENSVDVYQVAKMinlMRPGVFADIEQYQFLYKV
...| .. ... .  |    .|   .  . . . || .
reveadptieltealkh...lrehrwngvqtnsqlywm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2034-2197 3.3e-16 54.0 In-house 19-180 (297) alignment 
Range on Protein: 2034-2197
Range on HMM: 19-180/297.0
NIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSgEGTDYINASYIMGYYQS--NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
. .  ..|.| ..    |||   |. .. .|| .      ..||||| |..   .     .|..| ||  |..|||....... . .||.   |.   | 
eargesfssakrnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

-FVYWPNKDE-PINCESFKVTLMAEEHKclsNEEKLIIQDFILEATqdDYVLEVRHFQCPKWPNPDSP
 . |||. ..   .. .. |  ...      . ...|. .. |     .    ||| |   ||.   |
capywpsvvqerlkagdvvveflsstsd...efdrviltelqliyr..sesrvvrhvqflswpdhGvp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2040-2158 3.8e-16 53.5 In-house 88-203 (244) alignment 
Range on Protein: 2040-2158
Range on HMM: 88-203/244.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSgEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdGQNMAEDEfvYWPNKd
   |..  |  ||| .. .|.. .|| .|  |  |  |||||..    .. |.|.|||||  |  |||.|. .   ...|..  |    |||  |||.  
mkdafnpnnswknregaglpfdfnrvplskgs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl..gsveeede..ywpds.

EPINC--ESFKVTLMA-EEHKC
||..   |   |||   .| | 
eplewyeeditvtltdrdefkn
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2047-2282 6.6e-16 52.8 In-house 55-282 (290) alignment 
Range on Protein: 2047-2282
Range on HMM: 55-282/290.0
CNREKNRTSSIIPVERSRVGISslSGEGTDYINASYIMGYyqSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP----DGQNMAEDefvYWPNKDEPI
 . .|||   ..  ...|| ..   |   ||. | |. |      ||.|| .|  |. |.|||. ....  .||.     ||.   |.   |.|.|.  .
tefkknrykdvvcndktrvilk..dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq...yypekeGev

-NCESFKVTLMAEEHKclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKeEAANRDGPMIVHDEHGGVTAGTFCALTTLMH
    .. |.   |..|    ....| . . .   ..     ..|..   ||.   . | |. |. ...    .  ||..||   |   .||| |. . . 
ltfGeitvlcseeddk....daniikktlsvrdkdsGkehklkhlkikswpdksvals.tlallrtlr.ilrkasGpvvvhcsaGiGrtGtfvaievglq

QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
 | .  ..|. .. . .   | .      ||  | ...| |
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1930-1993 7.7e-16 52.2 In-house 1-64 (69) alignment 
Range on Protein: 1930-1993
Range on HMM: 1-64/69.0
VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|||||.| |||||.| .   . .|. |  |.||  ....|  |  .|  |..|.||||.||||.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2034-2286 1.1e-15 52.1 In-house 40-292 (305) alignment 
Range on Protein: 2034-2286
Range on HMM: 40-292/305.0
NIQQSDYSAA-LKQCNREKNRTSSIIPVERSRVGISSLSgeGTDYINASYIMGY-YQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
.. |  . |    . .  ||| . .   ..| | ..  |   .||| | |.       . || .| || .|| .|| |. ... . .||.    ..    
dmtqvafnanqsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

F-VYWPN-KDEPINCESFKVTLMAEEHKCLSNEEKliIQDFILEATQ-DDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEaanrDGPMIVHDEHG
   |||  . |  .  |  |       | .  . .  ||  .|. |   |  . |||.|  .||.   |  |  ..||.| |.        |..||   |
caqywpaaqgeklelksgivvenvsgskpmerdae..iqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsag

GVTAGTFCALTTLMHQLE-KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
   .||  |.  .. ..  . .   . .. | .   |     .  || |...|.|  .  .
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1749-1840 3e-15 50.5 In-house 33-121 (332) alignment 
Range on Protein: 1749-1840
Range on HMM: 33-121/332.0
DNKHKNRYINIVAYDHSRVKLAqlaEKDGKlTDYINANYVDGYNRPKAYIAAQGPLKSTAE-DFWRMIWEHNVEVIVMITNLVEKGRRKCDQY
.|   ||   . ..|||||.||    .|||  |. ||..||||..  ||| || |..  .|  ||||. |..  .|... .. || .||.   
nnmdmnriphlycfdhsrvela...pqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2041-2286 5.7e-15 49.8 In-house 40-290 (305) alignment 
Range on Protein: 2041-2286
Range on HMM: 40-290/305.0
SAALKQ-CNREKNRTSSIIPVERSRVGISSlsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQ-NMAEDEFVYWPNK
  |.|.  ...|||   .  ... || . .      .|| | |.    ... || || || .|  ||| | .... . . |. . .   |.  . |.. |
mkafkeaqeagknrykdvgcldnnrvkleg..pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

DEPI---NCESFKVTLMAEEHKCLSNEE----KLIIQDFILEATQdDYVLEVRHFQCPKWPNPDSPISKTfELISVIkEEAANRDGPMIVHDEHGGVTAG
|...   . .  |...  |  . |. ..    |.    ...| .    .. | |.    ||.   | . .  .. .. |.|    ||..||   |   .|
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadl.ailell.ekarpskgpivvhcsagigrtg

TFCALTTLMHQLEKENSVD-VYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
.   |  ...||   . ..   .. . |   |       .|| |...|||  .  .
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_CG42327_pd Subfamily CG42327 1921-1990 5.9e-15 49.7 In-house 242-312 (319) alignment 
Range on Protein: 1921-1990
Range on HMM: 242-312/319.0
AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
..|.  ||.||||| ||||||. |  |  ......   .|.|   . ..| .|   |.| ||| ||. .| 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2045-2281 6.8e-15 49.8 In-house 32-268 (285) alignment 
Range on Protein: 2045-2281
Range on HMM: 32-268/285.0
KQCNREKNRTSSIIPVERSRVGissLSGEGTDYINASYI-MGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEFVYWPNK-DEP
 ..| . || . .  .| .||    |     ||| ||.. |   . . .| || ||  |. |||.||.. .   |.|.    .   |   .|.|.|  | 
yeanpdlnryadvrcieetrvv...lknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

INCESFKVTLMAEEHKCLSNeekLIIQDFILEATQDD--YVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEeAANRDGPMIVHDEHGGVTAGTFCALT
..   ...||   . ....     |.. . .  |.|     | . | | | ||.  .|       ||   .|.    .. |. ||   |   . ||  . 
vkfgkyeitlteckeeaiag...tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgid

TLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
    .. ..  ... .. . .  ||        |. ||| |.. 
yatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2025-2178 1.5e-14 48.5 In-house 24-190 (350) alignment 
Range on Protein: 2025-2178
Range on HMM: 24-190/350.0
KQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIS---------SLSGEGTDYINASYIMGY----YQSNEF--IITQHPLLHTIKDFWRM
 .. | |.|. .. |.  .       ||| . |.| |.||| .            | .. |||||.|.        .  .|  | || ||  |..||...
srlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykv

IWDHNAQLVVMI-PDGQNMAEDEFVYWPNKDepINCESFKVTLMAEeHKCLSNEEKLIIQDFILEATQDD
|   . ...... .|  .  |    ||.. .  ..    |.. . |   .  |.  |   |   ||...|
illnkvkvilsltsdvelnlekcyrYWqegs..ydditvklaskwe.nimgindsslysadvkkeasdnd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1740-1849 2.6e-14 47.5 In-house 87-186 (244) alignment 
Range on Protein: 1740-1849
Range on HMM: 87-186/244.0
ITADSSNhPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrkcDQ
.  |. | |.| .|||    . .| .|| |.    |      |||| .|    |   || .| ||  |. |||.|. |  |.|.|..  . |.     |.
vmkdafn.pnnswknregaglpfdfnrvpls....kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....de

YWPADGSEEY
|||     |.
ywpdseplew
fn3 Fibronectin type III domain 313-401 5.6e-14 45.2 Pfam-A 1-85 (85) alignment 
Range on Protein: 313-401
Range on HMM: 1-85/85.0
SEPENVQADPENYTSLLVTWERPRvVYDTMIEKFAVLYQQLDGEDqTKHEFLTDGYQDlGAILNNLLPNMSYVLQIVAICTNGlYGKYS
|.|||..... . ||| ..|. |.   .  |... | |.. .|..  ..|| ... ..  ..|..| |...|.... |. ..| .|..|
saPenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge.ewkeftvprttt.svtltgLkpgteYefrVqavngag.egpeS
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1703-1802 5.9e-14 46.0 In-house 9-95 (95) alignment 
Range on Protein: 1703-1802
Range on HMM: 9-95/95.0
HFPKHVADLHASSGfteefetlKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDgklTDYINANYVDGYNRPKAYIAAQG
 |  || ..|. |         .|| .|..| ..  | .        |  |||..||. || .|| |.    .|   .||||| .|||| | ..||||||
vfhshvlemhsnsd........qefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt..krd...sdyinacfvdgyarkncyiaaqg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1927-1992 2.2e-13 44.7 In-house 229-294 (297) alignment 
Range on Protein: 1927-1992
Range on HMM: 229-294/297.0
GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
 ...|||||||||.|  .  | .|......   ..  .|...|.||  |||| ||. ...|  .. 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2021-2286 3.6e-13 43.6 In-house 26-288 (302) alignment 
Range on Protein: 2021-2286
Range on HMM: 26-288/302.0
TKLEKQFQLLSQSNIQQSDySAALKQcNREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTI---KDFWRMIWDHNAQL
....|.|. ...  ..      | |. | .||..  .  ..  .|    |..|  .|.||| .     ... |..| | . .     .||||..... . 
aevkkefkkidtmkvdlek.Ckafkk.nlkknqsedvpildsnlv...kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVMIPDGQNMAE--DEfvYWPNKDEPIncESFKvTLMAEEHKCLSNEEKLiiQDFILEATQDDY----VLEVRHfqCPKWPNPDSPISKTFELISVIK--
||..   ... .  .|  ..|.| .    . .. ...    |  . ||.   . ...|   ...    . .| .  .  |..   |.. .    .. |  
vvilvgeeelkktlse..lfpkksgdy..keyg.kmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakvf

EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
.. .. | ....  ..|   ||.| .|.. ...|.|.. . . ...| |   || .   ..|| .|| ..| .. ..
akkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2048-2280 1.8e-12 41.5 In-house 47-276 (303) alignment 
Range on Protein: 2048-2280
Range on HMM: 47-276/303.0
NREKNRTSSIIPVERSRVGISSLSgegtdYINASYIMgYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI-PDG-QNMAEDEFVYWPNKDePINCE
| .|||   .| .. |.| .|  |     || |||.     |.  |.|| || ||  |||.|| . . . |...  |.  .    ..|.  |.|  .. |
nmdknrfvdvicldhskvklsdss.....yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfe

SFKVTlmAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQcpKWPNPDSPIS-------KTFELISVIKEEAAnrDGPMIVHDEHGGVTAGTFCALTT
   .     | | .   .   ..   .   .    | | |..  .||  . |         . ..| ||..  .     | .     |   ||||. . |
ersir..vgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfet

LMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
    | .| .|.|. .. ...   |     .. |. ..| .. 
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1789-1873 3.3e-12 40.5 In-house 230-312 (440) alignment 
Range on Protein: 1789-1873
Range on HMM: 230-312/440.0
DGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLR
.|| . .|.||.| || ||  ||||.. ....  |.|. .| .|    |  ||| .  |  .| | | .|  . .    || . |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2047-2281 2.3e-11 38.2 In-house 42-269 (288) alignment 
Range on Protein: 2047-2281
Range on HMM: 42-269/288.0
CNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNKD-EPINC
 |  ..|   .   . .|| .|    .   ||.|  .      . .| .| ||  ||. .|.|. . . . .||. .  .   |   .|.| |  | .  
anptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

ESFkVTLMAEEHkclSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDspISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFcALTtLMhQLE
  .  | . ...   .. .||.    .    . .    |..    .|..    . . .     . |   . . |..|| ..|   .||. .|. |.  ||
grl.ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddg..vPenylsplrllevlkslqkPivvhssaGvGrtgtl.ili.li.ale

KENSVDVYQVAKMINLMRPGVFADIE---QYQFLYKVILS
   ..|   . .... .|   |  |.   || ......| 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2071-2176 7.7e-11 36.4 In-house 11-111 (130) alignment 
Range on Protein: 2071-2176
Range on HMM: 11-111/130.0
SgeGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdGQNMAEDEfvYWPNkDEPIN--CESFKVTLMAEEHKCLSNEEKLIIQ
   | .|||||..    ...|.. |||||  |  |||.|. .    ..|..  |    |||  |||.  ||..   |   |||   .     . ..| |.
q..gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl..gsveeede..ywpd.sePlewyeediivtltdrdefknikasnleie

DFILEATQ
. . |. |
sdlneshq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2075-2283 2.8e-10 34.8 In-house 46-259 (290) alignment 
Range on Protein: 2075-2283
Range on HMM: 46-259/290.0
TDYINASYIMgYYQSNEFIITQHPLLHT-------IKDFWRMIWDHNAQLVVMIPDGQNMAED--EF---VYWPNK-DEPINCESFKVTLmaeehkcLSN
 ||| |...  . .  ..|.|| |. ..       |..|| |. . ... |||. . ..  ..  .|    | |.. .| .. . ..|          | 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.......ksk

EE--KLIIQDFILEaTQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAaNRDGPMIVHDEHGGVTAGTFCALtTLMHQL--EKENSVDVYQVAKM
|.   ...   ...  .|.  . | | .   | .   .  .|  |.|.|.    ... |.|||.  |     .. |.  |  |.  |...|| . .| |.
ekeddvetRelvvk.fddeeeftvtHsllkgWnklnvq.edtktllsliqkvk.asktpvivHcvdGiSrsAalaai.ilgyQkiaetsgsvkledvlka

INLMRPGVFADIEQYQFLYKVILSLV
.  .|  .. . ... |   .|. |.
lrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2054-2132 6.3e-10 33.1 In-house 52-128 (347) alignment 
Range on Protein: 2054-2132
Range on HMM: 52-128/347.0
TSSIIPVERSRVGissLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEF
|  ..  |.|. .    . .   |||||.|     |.|.|.||.|| .|..|||.|.   .   || | .  .. | .||
trvvlspekskns...raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieef
0048076 (Phosphotyrosine protein) phosphatases II 2173-2281 6.3e-10 34.4 In-house 37-141 (145) alignment 
Range on Protein: 2173-2281
Range on HMM: 37-141/145.0
EATQDDYVLEVRHFQCPKWPNPDSPIS-KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHqlekeNSVDVYQVAKMINLMRPGVFADIEQ
  ...... .. ....  ||  . | . .... .  . ||| ...||..||  .|   .||..|.  ...     ..|..... ...  .|||..   .|
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YQFLYKVILS
..|||...| 
lrflyefele
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1762-1848 6.6e-10 33.4 In-house 5-76 (130) alignment 
Range on Protein: 1762-1848
Range on HMM: 5-76/130.0
YDHSRVKlaqlaekdgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrkcDQYWPADGSEE
.. ||..            .||||..|   .| . |. .| ||  |. |||.|. |  |.|.|..  . |.     |.|||     |
fevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2084-2192 9.8e-10 32.3 In-house 230-329 (440) alignment 
Range on Protein: 2084-2192
Range on HMM: 230-329/440.0
MGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgQNMAEDEFVYWPnkdepINCESFKVTLMAEEHKCLSNEEKLIIQdfILEATQDDYVLEV
 || . | || || ||  |. ||||.. |..   ..|.   |       .|||     .|  |     ..  ||   | ... ..   ||    . | |.
egyskknafiatqmpldstvldfwrlvhdyristiimln..qlndktcsiywp.....vntrsvtfgpftvghkgsenmnrvkvr..tlelkykeevhei

RHFQCPKWP
| |.   ||
rqfevqtwp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1727-1791 8.9e-09 29.2 In-house 24-86 (440) alignment 
Range on Protein: 1727-1791
Range on HMM: 24-86/440.0
FYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGY
| .|       |   .| .. |.|| |||| ||.||||||| | ..  |    .||||| |..| 
fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleev..kgvpdsdyinasyingi
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1749-1844 2.2e-08 27.2 In-house 26-87 (169) alignment 
Range on Protein: 1749-1844
Range on HMM: 26-87/169.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINAnyvdgynrpkayiaaqgplkstaedfwRMIWEHNVEVIVMITNLVEKgrrkcDQYWPAD
 |. |||    .|  | |||| .. |. |  .|||||                           ||||| |  |||.. .  .|     ...||  
cnetknrpagplapshtrvklqrvmedlg..sdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1749-1843 2.8e-08 26.8 In-house 25-85 (169) alignment 
Range on Protein: 1749-1843
Range on HMM: 25-85/169.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINAnyvdgynrpkayiaaqgplkstaedfwRMIWEHNVEVIVMITNLVEKgrrkcDQYWPA
 |. |||    .|  | |||| .. |. |  .|||||                           ||||| |  |||.. .  .|     ...|| 
cnetknrpagplapshtrvklqrvmedlg..sdyina...........................rmiwetnasvivvlGdtddk.....nnfwpe
0048179 (Phosphotyrosine protein) phosphatases II 2169-2277 3.2e-08 28.9 In-house 35-139 (144) alignment 
Range on Protein: 2169-2277
Range on HMM: 35-139/144.0
DFILEATQDDYVLEVRHFQCPKWPNPDSPIS-KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTtLMHqlekENSVDVYQVAKMINLMRPGVFA
... |  ....  |. ....  ||. . | . . .. .  . ||| ...||..||  .|   .||..|.  ||.    .. ...... ...  .|||.. 
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay.lmk....klglsleealalvrsrrpgavp

DIEQYQFLYK
  .|..||..
npgqlrfLle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1749-1827 4e-08 27.2 In-house 36-117 (347) alignment 
Range on Protein: 1749-1827
Range on HMM: 36-117/347.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGKL---TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT
 .  |||  .    | .|| |.    | ..      |||| ..   |  | || .| || .|  |||.|.   .|  .| | 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_eak_pd Subfamily eak 2048-2210 6.4e-08 26.4 In-house 52-209 (332) alignment 
Range on Protein: 2048-2210
Range on HMM: 52-209/332.0
NREKNrTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEFVYWPNKDEpincES
. ..|    |.| .|  | ..|   .   ||||| .      ...|.|  .    .  ||.|. . ..  .|.. .  ..  |    |.|.|      | 
avnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr....ee

FKVTLMAEEHKCLSNEEKLIIQDFILEATQDdyVLEVRHFQCPKWPNPDSPISKTFE-LISVIKE
.|   .  | |   ....|  . ..|.   .    .| |..   | . . |. . |  |  |.||
lkfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkyedflalrkvmke
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2036-2140 1.1e-07 24.9 In-house 16-89 (169) alignment 
Range on Protein: 2036-2140
Range on HMM: 16-89/169.0
QQSDYSAALkQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINAsyimgyyqsnefiitqhpllhtikdfwRMIWDHNAQLVVMIPDgqnmAEDEFVY
.  .. | |  ||  ||| .. .   . || .  .    |.|||||                           ||||. || ..|.. |    ..|   .
eynnfmael.tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd....tddknnf

WPNKDE
||.|..
wpeked
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2084-2286 1.3e-07 24.6 In-house 109-312 (346) alignment 
Range on Protein: 2084-2286
Range on HMM: 109-312/346.0
MGYYQSNEFIITQHPLLH---TIKDFWRMIWDHNAQLV-VMIPDGQNMAEDEFVYwpnKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDY
. .   ...|..| | ..    ..||| ||.. . .|| .|.|| .       ..   .||    .     .. . .  .| . |    . . |   |  
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslf...ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv

VLEVRHFQCpkWPNPDSPiSKTFELISVIK---EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLY
. .| |     |   . |  ||. .| .|.    |   ..  . |    |   | .|      ..||.     ..... | |   |||    . ||  .|
icqvhhhap..wkhlqqp.pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy

KVILSLVSTR
 ...  .. .
aivfdyiark
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2036-2140 1.4e-07 24.5 In-house 15-88 (169) alignment 
Range on Protein: 2036-2140
Range on HMM: 15-88/169.0
QQSDYSAALkQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINAsyimgyyqsnefiitqhpllhtikdfwRMIWDHNAQLVVMIPDgqnmAEDEFVY
.  .. | |  ||  ||| .. .   . || .  .    |.|||||                           ||||. || ..|.. |    ..|   .
eynnfmael.tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd....tddknnf

WPNKDE
||.|..
wpeked
subfamily_CG42327_pd Subfamily CG42327 2213-2280 1.5e-07 25.4 In-house 244-312 (319) alignment 
Range on Protein: 2213-2280
Range on HMM: 244-312/319.0
ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 .. ||..||   |   .|.  |    ...||.  .|||. |.   .   |     ..|||.|.|||. 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1803-1996 2.4e-07 23.7 In-house 123-312 (346) alignment 
Range on Protein: 1803-1996
Range on HMM: 123-312/346.0
P---LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY-GNFLVTQKSVQVLAyyTVRNFTLRNtkIKkgsqKGRpSGRVVTQ-YHYT
|    .|  |||| ||.. ..... ..             .   .|  .| |.... ..  .|      ...|.    .     .|  |  |. | .|..
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsg..dpkeytiev..lp....egn.sdsvicqvhhha

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
 |  .  |  .||.. .. .    |.     | |    | ||. ..|     ..|..     ||.  .| |. ||   |..  ||  |.  ... |  |
pwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1920-1987 2.5e-07 24.3 In-house 259-338 (349) alignment 
Range on Protein: 1920-1987
Range on HMM: 259-338/349.0
YAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQ--QIQHE----------GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD
| .   . ...|||||| ||||... ||..|.  .  ..              |.  . ..| ||  .||   |...|..
yldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiye
subfamily_PTPDC1_pd Subfamily PTPDC1 1894-1987 5.5e-07 24.2 In-house 85-170 (182) alignment 
Range on Protein: 1894-1987
Range on HMM: 85-170/182.0
YHYTQWPDMGVPEYSlPVLTFVRKAAYAKRHAvgPVVVHCSAGVGRTGTYIVLDSMLQQiQHEGTVNIfgflKHIRSQRNYLVQTEEQYVFIHD
..   |.| ||.     .|. |. .|.| ..    | ||| || ||||  |    . .. . ..   |    | .||.|   .|| ||  ....
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyak.rltaekai....klvrskrpksiqtreqvelvke
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2023-2282 8.1e-07 23.0 In-house 21-275 (312) alignment 
Range on Protein: 2023-2282
Range on HMM: 21-275/312.0
LEKQFQLLSqSNIQQSDYSAALKQcnREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
| |... .    ...|. .| ||   .. ||   |   .| |    .|.|.   || | ..    . . |..|| ||  |.  ||..     .  .... 
ltkeykavg.nivsdsectaflkf..kdlnrypniqcwdrgrf...tlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

DG-QNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ----DFILEATQDDYVLevRHFQCPKWPNPDSPIS--KTFELISVIKEEaanr
   .. .|    |  .    .. |  .|         .    |  |       .. || ..  |   |.|   ||.   | |   .. |.| .| .    
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl..nhyqwaswpdhgmpdscdtalrllsavkkd....

DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
  |.| |   |   .||.. . ...  | .    .| ..  ..   |      . || .  ...| .
kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2050-2138 9e-07 22.5 In-house 50-156 (349) alignment 
Range on Protein: 2050-2138
Range on HMM: 50-156/349.0
EKNRTSSIIPVERSRVGI---------------SSLSGEGTDYINASYIMG--YYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDE
 ||| . |.| | ||| .                | ||   ||||| |.    .   . .| || ||  |..||...|   . .||. . | .. . |  
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

FVYWPNK
 .|| . 
diywqel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2210-2279 1.4e-06 21.9 In-house 364-434 (440) alignment 
Range on Protein: 2210-2279
Range on HMM: 364-434/440.0
EEAANRDGP-MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVI
|..   ||| ..||   |   .| ||..   . ||... ..||.|  ... | ||     . .| . ||..
eqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2047-2123 2.1e-06 21.5 In-house 33-109 (332) alignment 
Range on Protein: 2047-2123
Range on HMM: 33-109/332.0
CNREKNRTSSIIPVERSRVGISSLSGEgTDYINASYIMGYYQSNEFIITQHPLL-HTIKDFWRMIWDHNAQLVVMIPD
 | . ||   .  ...||| ..   |.  |. |||.. || . . .|..| |.  ||   ||||. ...  ..... |
nnmdmnriphlycfdhsrvelapqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
0038934 (Phosphotyrosine protein) phosphatases II 1892-1946 2.8e-06 22.6 In-house 80-135 (194) alignment 
Range on Protein: 1892-1946
Range on HMM: 80-135/194.0
TQYHYTQWPDMGVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVL
 .|.  ..|| |..     .|.|.. .  . .... | |.||| ||.||||| .. 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_CDC14_pd Subfamily CDC14 1908-1969 7.7e-06 20.0 In-house 245-304 (328) alignment 
Range on Protein: 1908-1969
Range on HMM: 245-304/328.0
SLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLdSMLQQIQHEgTVNIFGFLKHIR
| |  . |.|   .  .| | ..||| ||.||||| |    .... .   . .. ..|. .|
stPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhyrft.aaeaiawlricr