Gene PTPRM in Homo sapiens

Synonym: PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu, PTPRM

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRK
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP102_AA protein Get Run
HsapP102_AA_907-1198 phosphatase_domain Get Run
HsapP102_AA_1210-1492 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRK_pd Subfamily PTPRK 902-1234 2.4e-178 586.7 In-house 1-314 (314) alignment
Range on Protein: 902-1234
Range on HMM: 1-314/314.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGqsapWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
|||||||||||.|...|.||||||||||||.|||    ||.|||||||.|||.|.|.|||.|||.|.||.||..|||||...||.|.||...|.||||.|
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevSQRGVHEIREIRQFHFT
||..||||.|..||.|||.|.|.|||||||||.||||.|||.|.||||.|.|||||||.|.|.|.|||               ..||..||||.|||.|.
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrvek...............largqeeirevrqfqfl

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||||.||..|||||..||.||......||..||||||||||||.||.|||.|||.|||||||..|.|..||||.||||.|||||.||.|.||||||||.
gWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
|..|.|....||.....|||||||||.||||.|
taipvsefkalylesirldpqtnssqlkeefqt

subfamily_PTPRD_pd Subfamily PTPRD 902-1273 1.5e-146 484.3 In-house 2-356 (564) alignment
Range on Protein: 902-1273
Range on HMM: 2-356/564.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
...| ||.| .|. ..|  ... |.|||... |||. .|..|.|..|..|||| ||.|||||||.|...||| .||||| ..||||.....|||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHF
||| ||||||| .|...|.|.|.|.| |.||| ||||.. || | ...||| |.| ||.|.|||| ..|                    .| ||.|||||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.................ssesreVrqFhF

TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCG
| ||||||| .||.|| ..|.|.. ..| |||.||||||| ||||.|||||.||. .. |..||||..|..||. |  ||||||||.|||.|||||  ||
tsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

DTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNmVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPF
.|.|.......    ... ...|...... ||. |.  .    .|. . |  |.|..|||  .||. ..|   
ntevesenlkqhlqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvv

subfamily_PTPRK_pd Subfamily PTPRK 1254-1489 6.2e-115 378.3 In-house 42-275 (314) alignment
Range on Protein: 1254-1489
Range on HMM: 42-275/314.0
RNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVdPAQL---CPQYWPENGVHrH
 |.||||..|||..||...|||||||. ||.||||||.||||.|.||||||.||..|||||||||.|..|.|.|||...  ..    | .||||.. . .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev.y

GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEyngGEGRTVVHCLNGGGRSGTFCAISIVCE
|.|.||.|...|......||||....||.|...|.|.||||||||.. |.|||....|||.|.|.|.|||   ..||.||||..|.||.|||.||.||..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivld

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|......||||.||||||..|.|||.  .||||.|.|.||
mieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 905-1234 2.3e-109 360.3 In-house 2-317 (318) alignment
Range on Protein: 905-1234
Range on HMM: 2-317/318.0
IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET
| | || .|. ...      ..|||| .  . ... .  . .. |..|||| ||.||||.||.||..||...||||| ||||||.| . |||.|.|. ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsQRGVHEIREIRQFHFTG
| |||||||  |.| |.|.|...| |..|. .|||.. .. |....|.| |.  |..||.|.| |.                 .....| |..||.|.| 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvt.................rteeeesrqvrqyhyts

WPDHGVPYHATGLLGFVRQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||.||| ....|| .||||..   ...|||.||||||| |||| ||..||.|. .. |..||... |..||..|  |||||.||.||.|..|||  .||
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
| | ||..||   .... ||..  .... ||. 
tevdasdlrsrirelreqdpesgttemdaefqr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 905-1232 2.2e-101 334.1 In-house 5-318 (319) alignment
Range on Protein: 905-1232
Range on HMM: 5-318/319.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
|.|..| ....... .   ....|.. . |...  .|||.|.||. |||| ||.|||..|| |....|  .||||| ..||||.. . .||||.|...||
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-EIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancsPSREVSQrgvheiREIRQFHFTGW
 |||||||.|..  ..|.|.||| ..||. ||||. . | |  . ||| | | |..|.|| . ..|           | ||        ||. .|..| |
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnk..........kssevet......RevkhfqyteW

PDHGVPYHATGLLGFVRQVK-SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
|||.|| .||.|| ...... |.. ...||.|||||||.|||| |||.|.||.  ..|||.|... |..||  |  |||..||| ||..|.|||  .|||
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

SVPASQVRSLYYDMNKLDPQTNSSQIKEEF
 .   ..|    .... ...|  .... ||
eievqdlrdrlkqlaekvadtgetgleref

0040438 (Phosphotyrosine protein) phosphatases II 909-1233 2.5e-101 334.3 In-house 4-312 (317) alignment
Range on Protein: 909-1233
Range on HMM: 4-312/317.0
DLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW
|||... ...    ....||.| . . .  ... |.. ||. |||| .|. ||||||.|. ..|| .||||| .|.||.......||||||...|..|||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHG
||||.... .|.|.|.|.| ||.||..||| ..|  |.|..|||...| ||....||. ||. |                   | |....||.|||||||
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd.................sesrtvthfhytgWpdhg

VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPAS
||.. . || |...|... ... ||..|||||| ||||.||....||.. |.|| ||....|.|||..| ..|||.|||.|..||.|| .....|..|||
vppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepas

QVRSLYYDMNKLDPQTNSSQIKEEFR
.  .... .   ....... ...|..
elklkllklliplalddvklkekelk

0051299 (Phosphotyrosine protein) phosphatases II 904-1197 8e-101 332.5 In-house 4-286 (288) alignment
Range on Protein: 904-1197
Range on HMM: 4-286/288.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQE
.|.| .||... ...    .|..||.| ... . . .. .|.. ||. |||| .|..||||||.|....|. .||||| .|||||......||||||...
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGeancspsrevsqrGVHEIREIRQFHFT
|..|||||||..|.  |.|.|.||| ||.||..||| .....|.||.|||...| |..|..||. |.. .  .             | .| |....||.|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.............gdgesrtvthfhyt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
.||||||| ... || |.|.|... ... || ||||||| ||||.||..|..|.. |.||.||... |. ||..| .||||.|||.|...|.||..
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 902-1232 2.3e-99 327.3 In-house 3-314 (315) alignment
Range on Protein: 902-1232
Range on HMM: 3-314/315.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
|  | . .|. ...| |..   |||..|||   ||  | | ||| ||. |||| ||||||.|||.|  .| | .|||.| |.|||| ....|||.|||  
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFavekggaggeancspsrevSQRGVHEIREIRQFHFT
... ||||.|..|. . |.|.|||||  . |. |||||.  ||  | ||... |   || .||.                   |     .|||. |.|.|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...................svvfgdnirevvqlhyt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
 ||| ||| ... |. ..|.||     |.|..||||||| |||| || .| .|| || | ..|.|| .. .|. |..|||. ||| ||.||.||. .|||
swpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
||.        |  .    |.| |. ..|.|
tsiaqdlylqrydsllapspdtgstllqeqf

subfamily_PTPRG_pd Subfamily PTPRG 905-1215 4e-99 327.3 In-house 1-305 (563) alignment
Range on Protein: 905-1215
Range on HMM: 1-305/563.0
IRVADLLQHITQMKCAEGYGFKEEYE---SFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPM
. | .. .|...... .  ||.||.|   |    .. . ....| ||. |||| ||.|||.|||.|. . |  .  |||| ||||||.. . .||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEANcspsrevsqrgVHEIREIRQFH
..|. |||||.| .|.| |.|.||||| || ||  ||| | .| |. ..|||||.| || | .||. ...     . .            .. ...||.|
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq...........cdteklvrqyh

FTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
.| ||||||| |..  | ||.. .   .  |||.|||||||.|||| .||.| .|   ..| .|.... .. .|..| ..|||||||.|.|||.||| . 
ytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

GDTSVPASQVRSLYYD
..| . |.||..|   
ketellaeqveelknc

subfamily_PTPRA_pd Subfamily PTPRA 901-1232 1e-98 325.3 In-house 10-330 (330) alignment
Range on Protein: 901-1232
Range on HMM: 10-330/330.0
LHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEG-QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGP
 .. . | .| . | . .. .   |.||....  |   |  . |.|.||. |||. ||. ||.||| |...||  .|||||  .||||.. ...||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

MQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE-IYKDIKVTLIETELLAEYVIRTFAVEKGGAGgeanCspsREvsqrgvHEIREIRQF
 .||. |||||.|  ..|.|.|.|.| |  . || .||||.    | .|.|.. ....| .| .| | |.. . .    .   ||      .. | .|||
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpda....t...re......kksrlvrqf

HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||.||| ||| .. |.| ....||.. . ||||.|||||||.|||| |||.| .|.. . |..||... |..|| .| .||||.|||.||. ..||  |
hftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

CGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
 ||| . .| . .    . .  ..|.   ..|||
ygdteldvsslekhlqklynkitgtdkigleeef

0050432 (Phosphotyrosine protein) phosphatases II 899-1201 1.1e-98 325.7 In-house 20-303 (308) alignment
Range on Protein: 899-1201
Range on HMM: 20-303/308.0
GQLHPAIRVADLLQHITQmkCAEGYGFKEEYESFFEGQS-APWDSAKKDENRMKNRYGNIIAYDHSRVRLqtiegDTNSDYINGNYIDGY--HRPNHYIA
 . .  ..| |||... .    . ....||.| ... .   ....|.. ||. |||| .|..||||||.|     | .||||| .|.|||  ..|...||
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIa

TQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD----DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHE
||||...|..|||||||..|.  |.|.|.||| ||.||..|||.    ....|....|||...| |..|..||. ... |                   |
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.................dge

IREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPsaGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHD
 |....||.|.||||||| ... || |...|... |.  || ||||||| ||||.||..|..|.. |.|| ||....|. ||..| .||||.|||.|...
srtvthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

AILEACLCGD
|.|| ...  
alleylklkl

subfamily_PTPRB_pd Subfamily PTPRB 904-1197 3.1e-98 323.4 In-house 6-285 (293) alignment
Range on Protein: 904-1197
Range on HMM: 6-285/293.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQE
 |.. .. .|...||  . ..|.||||.. . |..   ..|.. .|| |||| ||..||||||.|........||||| |||.||. |...||||||. |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD--TEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqrgVHEIREIRQFHF
|. ||||||| ...  |.|.|.||| |.||| .|||.|  . .| ||||||...| | ..|||....||                    .|.|..||.||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...................ekeerkvrqyhf

TGWPDHGVPYHATGLLGFVRQVKSKS--PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
| ||||||| ... || |||.|...     |..|.||||||| |||| || .| .|.  |.| .|||.  | |||..|...||||.||.|||...|. .
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

0043336 (Phosphotyrosine protein) phosphatases II 905-1195 7.4e-98 322.6 In-house 2-275 (278) alignment
Range on Protein: 905-1195
Range on HMM: 2-275/278.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
|.| |||... ... .. .....|.|.. . .  ... |.. ||. |||| .|..||||||.|. ..|| .||||| .|.|||..|...||||||..||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGgeancspsrevsqrgvhEIREIRQFHFTGWP
.|||||||.... .|.|.|.||| |||||..|||.... |.|..|||...| |. |..||. |.. | |                 | |.....|..|||
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdg.................esrtvthyhylgwp

DHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|||||.. . || |...|... ..| ||..|||||| ||||.||.....|...|.|| ||....|.|||..| ..|||..||.|...|.||
dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 925-1202 6.6e-96 316.3 In-house 2-279 (284) alignment
Range on Protein: 925-1202
Range on HMM: 2-279/284.0
FKEEYESFFEGQSA---PWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYINGNYIDGY-----HRPNHYIATQGPMQETIYDFWRMVWHEN
..||.|     .     ... |.. ||. |||| .|..||||||.|....||  .||||| .|.|||     ......||||||...|..|||||||..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TASIIMVTNLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHAT
.  |.|.|.||| ||.||..|||  ... .|.|..|||...|    |..||. ... |                   | |....||.|.||||||| ...
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy................tgesrtvthfhytswpdhgvppspe

GLLGFVRQVKSKSP--PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREG---VVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
 || |.|.|..  .  |. || ||||||| ||||.||..|..|.. |.||   .||....|. ||..| .||||.|||.|...|.||..... |
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 925-1210 4.1e-95 313.8 In-house 15-290 (297) alignment
Range on Protein: 925-1210
Range on HMM: 15-290/297.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
...|.|.... . . ... |.. ||. |||| .|..|||.||.|    .| .|||||..|.|||......||||||...|..|||||||..|. .|.|.|
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETEL--LAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGF
.||| ||.||..|||   ...  |.|..|||...|   |..|..||. |.. |                   | |....||.||||||||| ... || |
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn.................gesrtvthfhytgwpdhgvpespaslldf

VRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE---REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVR
...|..  |  || || .|||||| ||.|.||..|.||.. |   .|| |||...|..||..| ..|||.|||.|...|.|| .....| .|.... 
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 914-1204 1e-94 312.2 In-house 18-297 (298) alignment
Range on Protein: 914-1204
Range on HMM: 18-297/298.0
ITQMKCAEGYGFKEEYESFFEGQS----APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWR
 . .|  .  |...|.. . ...|    . .. |.|.||. |||| .|||.|.|||.|.....| .|||||  ....|.. | .||||.|..||. ||||
aavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWr

MVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGV
||..|. ..|.|.|||.|....|. |||||  .| | .|.|.| ..|  |....|...|.|                 . ... ||.||.||| |||.||
mvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvsk.................kkeekerevrqlhftsWpdkgv

PYHATGLLGFVRQVKSkSPPSAG--PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV
| .|| .|...|.|.  |.  ||  |..|.|||| ||.| ||.|| .|. ...| |||... |. || .|...||||||||||..|.|||  .... .
penatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0045450 (Phosphotyrosine protein) phosphatases II 901-1198 9.7e-94 309.8 In-house 5-305 (307) alignment
Range on Protein: 901-1198
Range on HMM: 5-305/307.0
LHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQS---APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYINGNYI--------DGYH
|.. |.. .||... ...    .|...|.|.... .     ....|.. ||. |||| .|..|||.||.|....|.  .|||||..|.        |||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD--TEIYKDIKVTLIETELLAEYVIRTFAVEKG-GAGgeancspsrevs
.....||||||..||..|||||.|....  |.|.|.||| ||.||..||||.  .  |....|||...| |..|..||. |.   | |            
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg............

qrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMV
     | |....||.||||||||| .   || |...|..  .. |. || .|||||| ||||.||....||.. |.||.   ||....|..||..| ..|
.....esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

QTEEQYVFIHDAILEACL
|..|||.|...|.|| .|
qnpeqyrflyeallelll

0039614 (Phosphotyrosine protein) phosphatases II 906-1201 1.7e-93 308.6 In-house 15-293 (297) alignment
Range on Protein: 906-1201
Range on HMM: 15-293/297.0
RVADLLQHITQMKCAEGYGFKEEYESFFEGQSaPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG-DTNSDYINGNYIDGYHR-PNHYIATQGPMQET
..  | ...  .|. . .....|.|.  . .  ..  |.. ||. |||| .|..||||||.|....| | .||||| .|.|||.. ....||||||..||
plsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IYDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgvhEIREIRQFHFTGW
..|||||||.... .|.|.|.||| || ||..|||.... |.|..|||...| |. |..||. |...|                   | |....|..|||
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnng...................esrtvthfqytgw

PDHGVPYHATGLLGFVRQVKSKSP--PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||||| ... || |...|..     |. || .|||||| ||||.||....||.. |.|| ||....|.|||..| ..|||..||.|..||.|| .....
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl





subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 905-1213 1.2e-91 302.0 In-house 4-299 (305) alignment
Range on Protein: 905-1213
Range on HMM: 4-299/305.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGqSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
| ..|| ..|..... .  |....|.|. |  . . |  ||..|. |||. .|. .|..|..|.. | . .||||| .|.|||.| ..||..|||...|.
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI---YKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFT
 ||||....| . .|.|.|.||| |. || .|||. .     . ...|.| ...  ..|..| . . .                    .| | . |...|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede................dkesrtvlqyqlt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAG-PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCG
 |||||||  || || ....|. .   . | ||.|||||| |||| ||..||.|. ...|.|||... ...|||.|..|||| .||||.|||. |   ||
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

DTSVPASQVRSLY
|||.  | .|   
dtsiigsnlrarv

subfamily_Ptp69D_pd Subfamily Ptp69D 903-1211 1.5e-91 301.8 In-house 2-300 (307) alignment
Range on Protein: 903-1211
Range on HMM: 2-300/307.0
PAIRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
.|| . || . ... |    .|...|||.  .   .     ..|.|| .|||| .|.|.|. ||.|..|.|. .||||| ..| ||.  ...|| |.|..
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGA-GGEAncspsrevsqrgvHEIREIRQFH
.|| |||||..  .   |.|..|| |  | || |||| .|.  | || |.|...|   .|.||.. | | .. .||              .. |.. |.|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev.............edsrkvvqyh

FTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
.|||.|  || .|.||| ...||..    . .|.|||||||.||.| |. .|..|.  . |  |||.. |..|||.|  .||  |||||.. |.|.    
ytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

GDTSVPASQVRS
||| .   .. .
gdtdedvddled

0047943 (Phosphotyrosine protein) phosphatases II 924-1196 1.9e-91 301.6 In-house 13-271 (273) alignment
Range on Protein: 924-1196
Range on HMM: 13-271/273.0
GFKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV
...||.| ... . . ..  |.. ||. |||| .|..||||||.|    || .||||| .|.|||......||||||...|..|||||||..|.  |.|.
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

TNLVEVGRVKCCKYWPDD----TEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGF
|.||| ||.||..|||..    ...|....|||...|  . |..||. ... |                  .| |....||.||||||||| . . || |
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.................tgesrtvthfhytgwpdhgvppslesllef

VRQVKSKSPP--SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
...|...     | || ||||||| ||||.||..|..||. |.|| ||....|. |||.| .||||.|||.|...|.|| 
ielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

DSPc_SM00195 925-1196 2.8e-89 294.3 In-house 2-261 (263) alignment
Range on Protein: 925-1196
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
.|||.|.  | . . . ..|.|..|. |||| ||. |||.||.|...|....||||| |||.|......|||||||...|. |||||||.|..  |.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLA-EYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFV
. .| |. || .|||..   .| ...|.|.|.|.|    |...||. ..| |                  .| |...|.....||||||| ... .| ..
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................eetrkvtqyqyknWpdhgvpdstksvlell

RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|.||...  | ||.||||||| ||||.|..|||.|.  |.|  ||| ..|.|||. | .||||.||| ||..||||.
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 925-1196 2.8e-89 294.3 In-house 2-261 (263) alignment
Range on Protein: 925-1196
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
.|||.|.  | . . . ..|.|..|. |||| ||. |||.||.|...|....||||| |||.|......|||||||...|. |||||||.|..  |.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLA-EYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFV
. .| |. || .|||..   .| ...|.|.|.|.|    |...||. ..| |                  .| |...|.....||||||| ... .| ..
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................eetrkvtqyqyknWpdhgvpdstksvlell

RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|.||...  | ||.||||||| ||||.|..|||.|.  |.|  ||| ..|.|||. | .||||.||| ||..||||.
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 911-1195 4.8e-87 286.7 In-house 9-277 (288) alignment
Range on Protein: 911-1195
Range on HMM: 9-277/288.0
LQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWR
........  .  ||.|||.|    ...   . ... .|  |||| ||..||. ||.|.  |  ...|||| .||||... ..|||||||...|. |||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsqRGVHEiREIRQFHFTGWPDHG
.|. ..|  |.|.|.||| |. || .||||. .   | ...|||.|.. | ..| |.. .|                  .  .| .|| |.....|||||
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..................kkkte.leitqyqylaWpdhg

VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||  .. ||...||||  ..  .||..|||||| |||| ||..| ..|. |.| ..|. . | .|| .| ..|||..||.||....|.
vPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 910-1196 1.4e-85 281.8 In-house 2-275 (281) alignment
Range on Protein: 910-1196
Range on HMM: 2-275/281.0
LLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW
| .|. |..  .  ||.||||.. . |.. .  ..|.|||..|||| ||.|||..||...  | ..|.|||| |...||. ...|||||||. .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT--EIYKDIKVTLIETELLAEYVIRTFAVEKGGagGeancspsrevsqrgvhEIREIRQFHFTGWPDH
.||| ..   |.|||. .| |..|| .|||||.   .| |..|. ...|  |.|. |.| .|. .  |                | ||..|...| ||||
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..g................etreveqlaytaWPdh

GVPYHATGLLGFVRQV-KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|||  .. ||.| ..| | ... .  |||.||||| ||||..| .| ... .|.|   .|. . |.||| .|  ||||  || |.. |.|.|
GvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

Y_phosphatase Protein-tyrosine phosphatase 948-1195 3e-85 280.7 Pfam-A 1-235 (235) alignment
Range on Protein: 948-1195
Range on HMM: 1-235/235.0
NRMKNRYGNIIAYDHSRVRLqtiEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEI
|. |||| .|..||..||.|   .|... ||||| ||..||......||||||...|| |||||||.|.. .|.|.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YKDIKVTLI-ETE-LLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
|.||||.|  ...   .||..|.. ..| ..                  | ||..|.|.|.||||||| ....|| ..|.|.... .. ||.|||||||.
ygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||||.|...||.|...|.|. ||....|.|||..| .|||..|||.|...||||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 948-1195 3e-85 280.7 In-house 1-235 (235) alignment
Range on Protein: 948-1195
Range on HMM: 1-235/235.0
NRMKNRYGNIIAYDHSRVRLqtiEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEI
|. |||| .|..||..||.|   .|... ||||| ||..||......||||||...|| |||||||.|.. .|.|.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YKDIKVTLI-ETE-LLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
|.||||.|  ...   .||..|.. ..| ..                  | ||..|.|.|.||||||| ....|| ..|.|.... .. ||.|||||||.
ygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||||.|...||.|...|.|. ||....|.|||..| .|||..|||.|...||||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 943-1199 8.4e-85 279.0 In-house 4-244 (250) alignment
Range on Protein: 943-1199
Range on HMM: 4-244/250.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVkCCKYWP-DDT
||| .|. |||| .|||.|.||| |.. .|| .|||||  ...||.  . .||||||.|.|| ||||||..|....|.|.|||.| ... . .||| . .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspSREVSQrgvheiREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP-SAGPLVVHCSAG
|.| |..|.| ..|  |.|..|.. . |            .. ..      | .||.||. ||| ||| .||  |.....|... .   ..|..|.||||
ekyGdvtvsllskeefadytkrklklsk...........akkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaG

AGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
 ||.|.||.|| .|. ...| |||... .. ||  |...|...|||||.. .||.|  .
vgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

0040439 (Phosphotyrosine protein) phosphatases II 940-1198 1.3e-83 275.6 In-house 3-247 (249) alignment
Range on Protein: 940-1198
Range on HMM: 3-247/249.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-
.. |.. ||. |||| .|..||||||.|. ..|   ||||| .|||||......||||||..||..|||||.|...  .|.|.|.||| ||.||..||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVH
...  |.|..|||...| ...|..||. ... .                   | |.......|.||||||| .   || |...|..  .. |. ||..||
ggsleygdftvtllsvevkddytvrtleltnly.................dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVH

CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||| ||||.||....||.. |.|. ||....|..|||.| ..||..|||.|...|.|| .|
CsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0050432 (Phosphotyrosine protein) phosphatases II 1194-1492 4.8e-83 274.3 In-house 9-300 (308) alignment
Range on Protein: 1194-1492
Range on HMM: 9-300/308.0
LEACLCGDTSVPASQVRSLYYDMNK-LDPQTNSSQIKEEFRTLNMVTPtlrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitidGESSNYINAALMDS
||..|..|||...|  .  ..|. | |..........|||..|..|.|   ....|.||||.|..||| .|||| |..  .|    .|.|.|||| ..| 
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdg

Y--KQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPEN---GVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqdGYRMV
|  |.| .||.||.||||||.||||.| ..... .|||.. .    . |.||||..   |. ..|...|...| . ..|.. | ... |   .   .|.|
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtv

QQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE
..|....||   ..| | ...|.....|.|..     ..| .|||| .| ||.|||.|. ...|.|.....||||.|||.||  .|.||  ..||.|.|.
thfhytnWp.dhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

VALEYLN
..||||.
alleylk

0042113 (Phosphotyrosine protein) phosphatases II 941-1195 1.7e-82 271.8 In-house 2-241 (245) alignment
Range on Protein: 941-1195
Range on HMM: 2-241/245.0
DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-D
..|.. ||. |||| .|..|||.||.|. ..||  ||||| .|.|||......||||||..||. |||||.|...  .|.|.|...| |||||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSP-PSAGPLVVHCS
..  |.|..|||...| |..|..||. |..                  | .| ||....|...||||||| .   || |.. |..    .| ||..||||
esltygdftvtllseehlddytvrtlevtnl.................gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|| ||||.||....||...|.|. |.....|.||||.| ..|||..||.|...|.||
aGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0051299 (Phosphotyrosine protein) phosphatases II 1200-1491 6.9e-82 270.4 In-house 1-286 (288) alignment
Range on Protein: 1200-1491
Range on HMM: 1-286/288.0
GDTSVPASQVRSLYYDMNkldpQTNSSQIKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSA
|||.........|.. .     ... ....|||..|  ..|.    ..|.|||| |.|||| .|||| |..  .| ..|| |.|.|||| ..| |... .
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--ARPQDGYRMVQQFQFLGWP
||.||.||||||.||||.| ..... .|||....  .   |.||||..|.  .|.|.|...| . ..|.. | ... |    .... .|.|..|....||
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

mYRDTPVSKRSFLKLIRQVDKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   ..| | ...|...|.|.|...    |.| .|||| .| ||.|||.|. ...|.|.....|||..|||.||. .|.||  ..||.|.||..||||
.dhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 922-1201 1.2e-81 269.4 In-house 7-276 (278) alignment
Range on Protein: 922-1201
Range on HMM: 7-276/278.0
GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRlqtiegdtnsDYINGNYIDGYhrPNHYIATQGPMQETIYDFWRMVWHENTASIIM
.  . | .. .  |.   .  | . .|. |||| .|..||||||.          |||| .|||||  |...||||||...|. |||||.|.... .|.|
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTNLVEVGRVKCCKYWPDDT-EIYKDIKVTLIETELLAEYVIRTFAVEKGG----AggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHA--TG
.|.||| ||.||..|||..  ..|.|..|||...| | .|..||. |.                          | |.....|...||||||| .   . 
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltvered.................lesrgvthlhylpwpdhgvpslpilks

LLGFVRQVKSKSP-------------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAerEGVVDIYNCVRELRSRRVN-MVQTEEQYVFIHDAILEACLCG
.| .......                .| || .|||||| ||||.......||..   ||.||....|.||||.| . .||..|||.|.....||  |.|
flellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

D
.
k

subfamily_PTPN6_pd Subfamily PTPN6 917-1194 1.6e-81 268.6 In-house 20-294 (306) alignment
Range on Protein: 917-1194
Range on HMM: 20-294/306.0
MKCAEGYGFKEEYESFFEG---QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQtIEGDTNSDYINGNYIDGYH--RPNHYIATQGPMQETIYDFWRMV
 .  |  ||.||.|.. .    .    . ..| ||. |||| ||. .||.|| |.  .. ..|||||.|||..      ..|||||| ...|. ||||||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

WHENTASIIMVTNLVEVGRVKCCKYWPDDT--EIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVP
| ||.  |.|.|. || |. ||..|||| .  | | .|.|| .. . ||.|..|.. |.|                 .  .| ||..|.||. |||||||
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk................kkkkeerevfqyhfksWPdhgvp

YHATGLLGFVRQVKSKSPPSA----GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
 .   .| |...|..|.  ..    ||.||||||| |||| ||||||.|.. |..|.   .||...|. .|. |  .||||.|| |.. || 
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 943-1212 1.5e-79 262.6 In-house 56-306 (319) alignment
Range on Protein: 943-1212
Range on HMM: 56-306/319.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgRVKCCKYWPDDTE
|  |.|. |||..||.|.|...|.|. ..|   |||||  ...|| |.. |||.|||...|. |||||.|  |...|...|      . ||..||| ...
anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

I-YKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsRevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK---SKSPpSAGPLVVHCS
| ..  || .   |  ||||.| . . . |          .       ..||.|.|||| ||||.||| ... |. .|..|.   ||      ..|||||
ikeerfkvkvdsveetaeyvvrdielsedg..........k......ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken.hranivvhcs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSL
||.|||| .||.|..||. ..|  ||.|| ||.|| .| ..||   || ||. |.||  | | . |   .. . 
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 943-1214 6.1e-79 260.5 In-house 20-272 (284) alignment
Range on Protein: 943-1214
Range on HMM: 20-272/284.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgRVKCCKYWPDDTE
|  |.|. |||.|.|.|.|...|.|. . |   |||||  .| || |.. |||||||...|. |||||.|  |...|...|      . ||..||| ...
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

I-YKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsRevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK---SKSpPSAGPLVVHCS
| ..  || .   |  .|||.| . . . |          .       ..||.|||||| ||||.||| ... |. .|..|.   ||      ..|||||
ikeerfkvkvdsveeseeyvvrdielsedg..........k......ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYY
||.|||| .||.|..||. ..|  ||.|| ||.|| .| ..||   || ||. |.||  | | . |   .. . . 
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle

0036941 (Phosphotyrosine protein) phosphatases II 1217-1492 1.6e-78 259.3 In-house 4-278 (297) alignment
Range on Protein: 1217-1492
Range on HMM: 4-278/297.0
NKLDPQTNSSQIKEEFRTLnmvTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRL
..|...........||..|   .| |   ..|.||||.| |||| .|||| |..   |   |.|.|.|||| ..| |... .||.||.|||||| ||||.
kllekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VLDYHCTSVVMLNDVDPAQL--CPQYWPEN--GVHRHGPIQVEFVSADL--EEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLI
|.....|..|||..... .   |.||||..  ..  .|...|...| .   ..|.. | .....     .  |.|..|...||| . ..| | .|.|..|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdh.gvpespaslldfi

RQVDKWQEEYNGGeGRTVVHCLNGGGRSGTFCAISIVCEMLR---HQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
..|.|.......| |...||| .| ||||||.|. .....|.   ....||.. |||.||. .|..|  |.||.|.||. ||.|.
elvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

0039614 (Phosphotyrosine protein) phosphatases II 1214-1492 6e-78 257.6 In-house 20-290 (297) alignment
Range on Protein: 1214-1492
Range on HMM: 20-290/297.0
YDMNKLDPQTNSSQIKEEFRTLNMVTPtlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALMDSYKQ-PSAFIVTQHPLPNTV
  ...|...........|| .|  ..|     |.|||||| | .||| .|||| |..   | ..||  ..|.|||| ..| |.. . .||.||.|||.||
dlllllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

KDFWRLVLDYHCTSVVMLNDVDPAQL-CPQYWPENGVhRHGPIQVEFVSADLEEDIISRIFRIYNaarpQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKL
.||||.| ....|..|||.. .. .  |.|||||.|  ..|...|.... . ..... | ... |     .  |.|..||..|||   ..| | ...|..
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwp.dhgvppslelllef

IRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
...|.....|. ...|...||| .| ||.|||.|. ...|.|.. ..|||..|||.||. .|..|  ..||.|.|...||.|.
lelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0047943 (Phosphotyrosine protein) phosphatases II 1218-1491 7.5e-78 257.0 In-house 4-272 (273) alignment
Range on Protein: 1218-1491
Range on HMM: 4-272/273.0
KLDPQTNSSQIKEEFRTLNMVTPtlrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV
.|..........|||..|  ..|   . ..|.||||.|..||| .|||| |..  .|   ....|.|||| ..| |... .||.||.||||||.||||.|
llekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

LDYHCTSVVMLNDVDPAQL--CPQYWPENG---VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdgYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQ
 ..... .|||....  .   |.||||..|   . ..|...|...| . ..|.. | ....|   ..  .|.|..|...|||   ..| |  |.|..|..
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwp.dhgvppslesllefiel

VDKWQEEYNGGeGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
|.|..|..... | .|||| .| ||.|||.|. .....|.. ..|||. ||| ||. .|.||  ..||.|.||..||||
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 1228-1492 1.1e-77 256.5 In-house 2-275 (284) alignment
Range on Protein: 1228-1492
Range on HMM: 2-275/284.0
IKEEFRTLNMVTPTLRvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALMDSY-----KQPSAFIVTQHPLPNTVKDFWRLVLDY
..|||..|...|..|   ..|.|||| |..||| .|||| |..  .| ..||  |.|.|||| ..| |     ... .||.||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

HCTSVVMLNDVDPAQ--LCPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIYNAaRPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQ
... .|||.. .  .   |.||||..| | ..|...|...| . ..|.. | ... |   . . .|.|..|....||  ...| | ...|...|.|....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswp.dhgvppspedlleflrlvrell

EEyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. ..|.| .|||| .| ||.|||.|. ...|.|....   .|||..||| ||. .|.||  |.||.|.||..||||.
en.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 925-1241 2.7e-77 255.0 In-house 20-320 (515) alignment
Range on Protein: 925-1241
Range on HMM: 20-320/515.0
FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
| ||.  .   .  |   |... |  ||||.||. || .||.|. |. . .|||.|  || ...  . |||.||| . .. ||||.|..||.. |.|||.
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

LVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ
| |  ..|| |||||   |.  .  ||| |. .|  .. ..|.. | ||                    ..| . |||||.|||.||| |.. || ....
lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg...................ddsrtvtqfhfteWPdkGvpkhtssllklike

VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDP
||..    . ||..|||||.|||| .| || ..  |.   .||..| |. .| .|. .|||.||| ||..|.||  |  .| .|  .      |.     
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

QTNSSQIKEEFRTLNMVTPT
    |.. .||.||. ..| 
grgrskmtkefqtlkslcpd

0037934 (Phosphotyrosine protein) phosphatases II 940-1195 4e-77 254.3 In-house 2-240 (243) alignment
Range on Protein: 940-1195
Range on HMM: 2-240/243.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDtnSDYINGNYIDGYhrpNHYIATQGPMQETIYD----FWRMVWHENTASIIMVTNLVEVGRVKCCK
.  |.. ||. |||| .|..||||||.|    ..  |||||.|.|...   ...||||||..||. |    ||||.|.... .|.|.|.||| ||.||..
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDDTeIYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsQ-RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK--------S
|||...  |.|..|||...| |..|..||. .|                      .. |.....|...||||||| . . || |...|..          
ywpgev.tygdftvtllseehlddytvrtllle.................nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellslla

PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAereGvVDIYNCVRELRSRRVN-MVQTEEQYVFIHDAILE
 .| ||..|||||| ||||..|....||..    | ||....|..||..| . .|||..||.|...|.||
ldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 943-1196 4.2e-77 253.5 In-house 2-239 (239) alignment
Range on Protein: 943-1196
Range on HMM: 2-239/239.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT
|||  |. |||| ||..|||||| |. .  |  ||||| .|.  |   |. |||||| .. .  |||||.|.|  . |.|.| |.|  . || .|||| |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EIYKDIKVTLIETELLAEYVIRTFAvekggaggeancspsreVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
  | ...||| .||..|.|.||||                  .|| |  | | . |.||| |||.||| .|| .||. |..   | | | | |.||||| 
skycnlrvtlrktevfadyiirtfv.................msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||||.|.||| ||  |...  |||.| |. .|  |  |||| ||||||| |.|||
grtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 942-1195 8.9e-77 252.4 In-house 2-239 (239) alignment
Range on Protein: 942-1195
Range on HMM: 2-239/239.0
SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD
.|||  |. |||| ||..|||||| |. .  |  ||||| .|.  |   |. |||||| .. .  |||||.|.|  . |.|.| |.|  . || .|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TEIYKDIKVTLIETELLAEYVIRTFAvekggaggeancspsreVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAG
|  | ...||| .||..|.|.||||                  .|| |  | | . |.||| |||.||| .|| .||. |..   | | | | |.|||||
tskycnlrvtlrktevfadyiirtfv.................msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsag

AGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
 ||||.|.||| ||  |...  |||.| |. .|  |  |||| ||||||| |.||
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1201-1494 1.1e-76 253.0 In-house 2-293 (298) alignment
Range on Protein: 1201-1494
Range on HMM: 2-293/298.0
DTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAF
.| . |.... .   ... ..... .. ..||..|| |. ... |  ..|  |.|..||| .||.. | .   | ..|  | |.||||. ...||. .||
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqdGYRMVQQFQFLGWPMyR
|.||.||..||.||||.| ... ...|||...   .   ...|||..| ...| |.|.  | .   |.|.| . . .. .   . |.|.|..|  ||  .
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd.k

DTPVSKRSFLKLIRQVDKWQEeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
..|  ..| |.|.|.| ..|.  . |.   .|.| .| ||||||.||. | | ......||||..||.||...|..|.  .||.|.||. ||.|.|.
gvpenatsvldllrkvrasqq..qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 925-1235 2.1e-76 251.8 In-house 21-315 (315) alignment
Range on Protein: 925-1235
Range on HMM: 21-315/315.0
FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
| ||.  . . .  .  .|....|  ||||.||. .|..||.|. |. . .|||||  || ...  . |||.||| . .. ||||||..|....|.|||.
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ
. |  ..|| .||||   |.  .  |||.|...|  .. |.| . . |.                   .| | . ||.||.|||.||. ... || ....
kqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks...................eesrtvtqfqftewPdkGvdkqtssllklike

VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDP
||..  .   .|.||||||.|||| .| || ... ..|. .||..| |..||. |. .|||||.| ||.||.||  |  .| ..  ..     |..    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

QTNSSQIKEEFRTL
 .  |.. .||.||
gsgrskmtkefetl

subfamily_PTPN9_pd Subfamily PTPN9 908-1197 2.1e-75 248.5 In-house 4-290 (297) alignment
Range on Protein: 908-1197
Range on HMM: 4-290/297.0
ADLLQHITQMKcaeGYGFKEEYESFFEG-QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYD
 .|.... ...     | ..||.   .   .   . .|.  |  |||| ... ||..|| |.....|..||||| |..|||.... .||||||...|. |
eelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsreVSQrgvHEIREIRQFHFTGW
|||||| ...  |.|.| .|| ||.|| .|||   .... . |..|. .|.|   .|..|.. ...              | .   .|.|..  | |..|
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn..............vkt...eesrkvthfqflsW

PDHGVPYHATGLLGFVRQVKS-------------KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
||.|||  |. || ....|..             | .||  |.||||||| |||| || .|| |.  |..|.||. ..|. ||..|  ..||.|||.| .
PdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcy

DAILEAC
 |.||  
lavleya

subfamily_PTPN12_pd Subfamily PTPN12 936-1197 3.3e-75 247.7 In-house 28-277 (290) alignment
Range on Protein: 936-1197
Range on HMM: 28-277/290.0
QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
.  . ....|.||. |||| .|. ||.||| |..||.. .|||||.|.| | . . .|||.|||. .|. |||||.|. |.  ..|. ..||.|. || .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDDTE--I-YKDIKVTLIETELLA-EYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAG
|||. .|  . . ...|||.| . .  ...|||..||.                    .| |...|||.| |||||||  |. || ....|..    .. 
YWpeegeeelefgefevtleeekavdddflirtLkveaq...................kesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||||||||| ||||  |.||.. .. ..| .   .|... |.||| .|. .|||.|||.... |..| .
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

0040438 (Phosphotyrosine protein) phosphatases II 1224-1492 7.8e-75 247.4 In-house 16-277 (317) alignment
Range on Protein: 1224-1492
Range on HMM: 16-277/317.0
NSSQIKEEFRTLNMVtptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC
.  ...|||..|  .     ....|.|.|| |..||| .|||| |..   |  ..| ..|.|||| ..| .... .||.||.|||||| ||||.| ....
dftalleefedllsl....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

TSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEey
|..|||.. .. .   | ||||....  .|...|...| . ...|. | .....     .  |.|..|...|||   ..| | ...|.....|....|  
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWp.dhgvppspdllldfleavreale..

nGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 ...| ..||| .| ||.|||.|. ...|.|.. ..|||..|||.||. .|..|  ..||.|.|...||||.
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

0045450 (Phosphotyrosine protein) phosphatases II 1214-1492 3.7e-74 245.5 In-house 15-305 (307) alignment
Range on Protein: 1214-1492
Range on HMM: 15-305/307.0
YDMNKLDPQTNSSQIKEEFRTLNMVTPTLrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALM--------DSYKQPSAFIVTQ
. . .|..... . ...||..|. ||..| . ..|||||| |..||| .|||| |..   | ..||  |.|.||||  .        |.|... .||.||
lllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

HPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVH-RHGPIQVEFVSADLEEDIISRIFRIYNAaRPQDGYRMVQQFQFLGWPmYRDTP
.|||.||.||||.. ....| .|||.. ..   . |.||||..| .  .|...|...| . ..... | ... .  .. .  |.|..|...|||   ..|
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwp.dhgvp

VSKRSFLKLIRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 |  ..|..|..|.|..||. ...|...|||  | ||.|||.|. .....|... |   ||...|||.||. .|..|  ..||.|.||..||.|.
psfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

subfamily_PTPRD_pd Subfamily PTPRD 1253-1494 1.2e-72 240.4 In-house 46-284 (564) alignment
Range on Protein: 1253-1494
Range on HMM: 46-284/564.0
PRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRH
| | .|||  .|.. |..   | ...| |.|.||||  .|.|... |.| ||.||..|..||||.| .......|||. .   .   | .||||.|  ..
paNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety

GPIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCE
| ..|....    .|.. | |.. ..   ..  |.|.||.|  ||  .. | | .|.|.|||.| ...|    ..| .|||| .| ||.|||..|... |
geltVtleeeeeladyeirtfklkkkk..ssesreVrqFhFtsWPd.hgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamle

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
 .....|||..  ||.||.... ||.  .|| |..|. ||.|..|
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

0043336 (Phosphotyrosine protein) phosphatases II 1223-1491 4.2e-72 238.2 In-house 17-277 (278) alignment
Range on Protein: 1223-1491
Range on HMM: 17-277/278.0
TNSSQIKEEFRTLNMVTPtlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYH
.. . ...|| .|. ...    ...|||||| |..||| .|||| |...  |  ..|. .|.|||| ..| |..| .||.||.|||.||.||||.| ...
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

CTSVVMLNDVDPAQL--CPQYWPeNGVHRHGPIQVEFVSADLEEDIISRIFRIYNaaRPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEe
.|..|||.. .  .   | |||| .|. ..|...|.... . ..|.. | ... |  .  . .|.|.....||||   ..| |  ..|.....|....| 
vttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale.

ynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
    .| ..||| .| ||.|||.|. ...|.|.. ..||...|||.||. .|..|  ..||.|.||..||||
..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 904-1232 2.3e-70 232.3 In-house 4-323 (325) alignment
Range on Protein: 904-1232
Range on HMM: 4-323/325.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET
.| | .|..|. . |. .  ||  |..     ..     | | ||. |||. |..|.|.||| |.| . |..||||| .|.  . . . ..|.| |. .|
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

IYDFWRMV--WHentASIIMVTNLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLAEYVIRTFAVeKGGAGGeancspsrevsqrgvhEIREIRQF
| |.||.|  |.   .|...|.| .. |  .|..|||..   .  .  ..| |.  | ...|| | . | |.  .|                | | ..||
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv.kqvkkG................etrsvkqf

HFTGWPDHGVPYHATGLLGFVRQVKSKS------PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDA
.. .|.| ||. . . |. ... ||  |        ...|..|||||| |||| || .  .|.    |  |||.. |. ||  | .||.| .||..|..|
qlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea

ILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
. || ..|.| || | . .    ... .| |.  .|..||
lveaymsgntdvpvssfeaklsslqernpltqklniekef

subfamily_CG7180_pd Subfamily CG7180 1226-1491 3.6e-70 230.9 In-house 13-290 (296) alignment
Range on Protein: 1226-1491
Range on HMM: 13-290/296.0
SQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
 . . |.. .  .||.|. .||  .|   | ||||  ...|.|   ..| ..|||. |.||||. .||. .. ..|||. |  .||..||||| | .. .
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--------ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDK
||.| .  | |...|.|||... ...|.| || |. .   .. .| |...          .  .   |.|..||.  |..    |.|  ....|.|.| .
vvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

WQEEY--NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
|.|.   .  || .||.. .|..||| ..|| .  |.....  ||||.||||||...|..|.  ..||..|.| ||..
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 947-1195 5.1e-70 230.4 In-house 2-237 (237) alignment
Range on Protein: 947-1195
Range on HMM: 2-237/237.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDtnSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD--DTEI
||..|||||||.||||||| |.   ..  ||||| .|..|.   |..|||.|||.. .  |||.||| |. . |.|.| |.|  ..|| ||||.  . . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YKDIKVTLIETELLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP--SAGPLVVHCSAGA
|  . |.|   | ...| .|.. . | .                   |.| | |..|| |||.||| ... || | ...  .||    .|| ..||||| 
ygvltvslkkkeefsdytvrslllskrltlk................evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|||| |.||| ||  |. . |||||| |  .   |  ..||..||||||..|||
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 947-1194 6e-69 227.2 In-house 27-265 (274) alignment
Range on Protein: 947-1194
Range on HMM: 27-265/274.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTN-SDYINGNYIDGYHR-PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI-
 .  |||| .|.  ..||| |.. ... . |.||| ||| ||..  . |.|||||...|. |||||...|..  |.|.|.| |  . || .|.||.... 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YKDIKVTLIETELLAEYVIRTFAVEKGGAGGEancspsrevsqrgvheireIRQFHFTGWPDHGVPYHATGLLGFVRQVKS---KSPPSAGPLVVH
    |.|....  ..    .| .|.. ...     .                   .  . .| |||| .| .|. || .|..|..   ..   ..| |||
iserygdveikvekiverndysvrklvlkylerers...................vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvh

CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
|||| ||||||| |.| .   ..|.|||. . | .||  |  ||||.||| .|| |. 
CsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

DSPc_SM00195 1227-1491 9e-69 227.1 In-house 1-262 (263) alignment
Range on Protein: 1227-1491
Range on HMM: 1-262/263.0
QIKEEFRTLNMVTPTLrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
..||||..|.. |..    ... |  ..|..|||  .||| |.    | .... |.|.||||  .. .......|.||.|||.||.||||.|.. ... .
klkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMLNDVDP--AQLCPQYWPEN--GVHRHGPIQVEFVSADLEE-DIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY
|||.. .    . | .||||.  |  ..| |.|..|. . .. .|| | ... . ..  .  | |.|.|. .||   ..| |..|.|.|.|.|.|.... 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

nggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   .| .|||| .| ||.|||..|.|... |... .||.|. || ||...|.||. |.||.|.||..|||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1227-1491 9e-69 227.1 In-house 1-262 (263) alignment
Range on Protein: 1227-1491
Range on HMM: 1-262/263.0
QIKEEFRTLNMVTPTLrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
..||||..|.. |..    ... |  ..|..|||  .||| |.    | .... |.|.||||  .. .......|.||.|||.||.||||.|.. ... .
klkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMLNDVDP--AQLCPQYWPEN--GVHRHGPIQVEFVSADLEE-DIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY
|||.. .    . | .||||.  |  ..| |.|..|. . .. .|| | ... . ..  .  | |.|.|. .||   ..| |..|.|.|.|.|.|.... 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

nggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   .| .|||| .| ||.|||..|.|... |... .||.|. || ||...|.||. |.||.|.||..|||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0040439 (Phosphotyrosine protein) phosphatases II 1246-1492 1e-68 226.9 In-house 2-247 (249) alignment
Range on Protein: 1246-1492
Range on HMM: 2-247/249.0
DCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP
..|.|||| |..||| .||||.|.. . |  ..| . |.|||| ..| |... .||.||.|||.||.||||.. ....|..|||.. ..   . | ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFC
..|.  .| ..|...| . ..|.. | ....|     .  |.|...|...||   ..| |  ..|..|..|.|..||. . .|...||| .| ||.|||.
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. ...|.|.. ..||...|||.||. .|..|  ..||.|.||..||.|.
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_CG7180_pd Subfamily CG7180 942-1201 1.9e-67 222.0 In-house 36-294 (296) alignment
Range on Protein: 942-1201
Range on HMM: 36-294/296.0
SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDD-
 . . ||| |||. ... ||. || |....|. .|||||  |.|.. ... || |..|..||. .|||.|. |.. .....|.  .  . .. .||| . 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

TEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeanCSPSREVSQRGVHEIREIRQFHFTGWPD-HGVPYHATGLLGFVRQVKS---KS--PPSAGPLV
 | |..| | ..|.. .|. .|||| . |             |  .  . | | ...|..| |.  . ||. ...|. ..|.|..   |    |  ||.|
keqygeifveiveekqyanlkirtfkltkk.......ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|..| ||.|.| .. ||. |...|.|. ||... |. ||  | ..|.. |.| .| | .||| ||. 
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

0045098 (Phosphotyrosine protein) phosphatases II 1240-1492 4.7e-67 221.6 In-house 18-273 (278) alignment
Range on Protein: 1240-1492
Range on HMM: 18-273/278.0
PTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFlitidgessNYINAALMDSYkqPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLC
..  . ... ||.. | .||| .|||| |..  .         .|||| ..|.|  | .||.||.|||.|| ||||.. ....|..|||... .   . |
llgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

PQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY--RMVQQFQFLGWPMYrDTPVSK--RSFLKLIRQVDKWQE----------EYNGG
.|||||.|. ..|...|...| .  .|.. | ....|    . ..  | |.....|.|| . ..| .   .|||.|.........           ....
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllssllllds

EGRTVVHCLNGGGRSGTFCAISIVCEMLrhQRTVDVFHAVKTLRNNKPN-MVDLLDQYKFCYEVALEYLN
.|...|||  | ||.||..|. ...|.|  ...||...|||.||. .|. .|  |.||.|.||..||.|.
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN3_pd Subfamily PTPN3 940-1196 1.4e-66 219.3 In-house 33-274 (280) alignment
Range on Protein: 940-1196
Range on HMM: 33-274/280.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYID----GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
 . |.| ||  |||| .|..||. ||.|.    ....|||| ||..    . .  |.|||||||...|  |||.|||....  |.|.|.||| |||||..
isaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPL
|||. ..   | ...|.. ...   .||.| . ...                 .  .| |.| |. .. ||||||| ... .| ||..|...   .  |.
yWPetedeleygefsvkcekedetksyvlrelvlkd.................ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePv

VVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||||||| |||| .|.... | . |..  | . . ||..| .| ..|||..|| |. .|||..
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 927-1208 3.1e-66 218.5 In-house 30-295 (297) alignment
Range on Protein: 927-1208
Range on HMM: 30-295/297.0
EEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRpnHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLV
||.    | .  |   |.|  |  |.|| ||. || |||.|. .. | .|||.|  .. |..   ..|.|| ||..|. |||.||..|... |.|.... 
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

EVGRvKCCKYWPDDTE-IYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPY--HATGLLGFVRQVK
|  . || .||.|..   . |. |.|  ..    .. |.. |.|| |                    | ..|..|. |||. |.   .|. || .. .|.
erdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka.................karrvvkqyqfveWPdkaverkdsassllklisevr

SKSP-PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQ
 .    . |||.|||.|| |||| .. || ..  |.||  |||.. |. ||  |...|||.||| |.. |.||| |. || ..|| 
kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy

Y_phosphatase Protein-tyrosine phosphatase 1255-1489 4.7e-66 217.9 Pfam-A 1-235 (235) alignment
Range on Protein: 1255-1489
Range on HMM: 1-235/235.0
NHEKNRCMDILPPDRCLPFLiTIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP--ENGVHRHG
|..|||  |||| |.    | . ....|.||||  ...||....||.||.||..|..||||.|........|||....    . |.||||  |..  ..|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC
 |.|| .  . . |.... | ... . ....   |.|.|... .||  ...| |..|.|.|||.| |..   .  .| .|||| .| ||.|||.|..|..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|.|.....|||...||.||...|.||. |.||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 1255-1489 4.7e-66 217.9 In-house 1-235 (235) alignment
Range on Protein: 1255-1489
Range on HMM: 1-235/235.0
NHEKNRCMDILPPDRCLPFLiTIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP--ENGVHRHG
|..|||  |||| |.    | . ....|.||||  ...||....||.||.||..|..||||.|........|||....    . |.||||  |..  ..|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC
 |.|| .  . . |.... | ... . ....   |.|.|... .||  ...| |..|.|.|||.| |..   .  .| .|||| .| ||.|||.|..|..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|.|.....|||...||.||...|.||. |.||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0042113 (Phosphotyrosine protein) phosphatases II 1247-1492 5.4e-66 217.8 In-house 1-244 (245) alignment
Range on Protein: 1247-1492
Range on HMM: 1-244/245.0
CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPE
.|.|||| |..||| .|||| |...  |  ..|.  |.|||| ..| |...  ||.||.|||.||.||||.. ....|..|||.. ..   . |.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

NGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCA
... ..| ..|...| . ..|.. |.... |   . | .|.|.....|.||   ..| . ...|.... |.|...|  ...|...|||  | ||.|||.|
gesltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia

ISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
. ...|.|.. ..|....||| ||. .|..|  ..||.|.||..||.|.
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 905-1197 6.9e-66 217.1 In-house 2-283 (290) alignment
Range on Protein: 905-1197
Range on HMM: 2-283/290.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAP-WDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD--TNSDYINGNYIDGYHRPNHYIATQGPMQ
|.| .. ..... .     ||.......  |.|      .   .|. .||. ||. ||  |. |. | |.   . .|||  ||.||.  ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEAncspsrevsqrgvheiREIRQFHF
.|. |||...|.|... |.|.|| .| |.||| .||||  |. |  ....|.. | | ||..|.. |..  ..|..                ... |...
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagak................qsvtqyqi

TGWPDHG-VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
| |...| |. ..| || . ...| .  .  ...|||||.. ||.. |..... .. .. |||.|... ....|. . ..|||..|| .|.. .|.. 
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 946-1204 7.7e-66 217.0 In-house 45-285 (287) alignment
Range on Protein: 946-1204
Range on HMM: 45-285/287.0
DENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-EIY
 .|. |||. .|. .|  || |.    ... ||||  .||||.  ...|....|| .|. .||......|   |.|.... |  . .| .|||...  ..
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

KDIKVTLIETELLAEYVIRTFAVEKGGAGGEAncspsrevsqrgvheiREIRQFHFTGWPDHG-VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR
 . ...|.. |  |.|..|.. |.. .  |.                 ....|...| |...| |. ..| || . ...|..  .. ...|||||.. ||
Geyniellneevnagyierklevknknkagdk................qqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV
.. |. ... .. ...|||.|... ... | .. ..||| ||| || |..||   ...| .
samfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 912-1208 9e-66 217.1 In-house 9-290 (439) alignment
Range on Protein: 912-1208
Range on HMM: 9-290/439.0
QHITQMKCAEGYGFKEEYESFfEGQSAPW----DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDF
.|. ...  .   |||..|.  .  | ..      | .. .. |||| .. |.||.|| || | |   | ||| |||.||. .. ||||||| .||  ||
ehvekldknkqeifkeifeki.nstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMVWHENTASIIMVTNLVEVGRvkcckYWPDDTEIY-KDIKVTLIETELLAEYVIRTFAVEKggaggeancspSREVSQRGvheiREIRQFHFTGWPDH
||.|....|. |.|.|||||  .     ||| |.|..  || |       | .|||| | | .            |. ...     | . |||.. |||.
wrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfn...........erdtteke....rtvlqfhyiawpdk

GVPYHATGLLGFVRQVKSKSP-PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVP
 || .|. .| |.| ..|       ||.||||||| ||||  | .|| |.    |  |||   |. || .| .|||.  |||||..|.||    ||..| 
nvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt

ASQ
  .
ide

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 918-1196 3.2e-65 214.8 In-house 10-292 (301) alignment
Range on Protein: 918-1196
Range on HMM: 10-292/301.0
KCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHEN
 ...  .|.|.|..  ||.. . .   ..||.. ||. ||  ||. |. |.. .    .. .||| .||||| . ...||.||||..|. ||||..|.| 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

TASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGagGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGV-PYH
..||.||||| |  . || .|||.   ..| .  ..|||...  . ..||| ..|      |  | .  |..  .  .. ... |.. | ||..|| . .
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd..gsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

ATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.| |     ... .  .. ||.|||||.. .|.| .. ..| |. . .|||||... .. .|  .  .|.| |||..|.|.| . 
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

subfamily_PTPN13_pd Subfamily PTPN13 941-1196 6.6e-65 214.1 In-house 30-268 (273) alignment
Range on Protein: 941-1196
Range on HMM: 30-268/273.0
DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsdYINGNYIDGYH--RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP
...||.||. |||| |.. ||..||.|.   |     ||| ..|         .|||.|||. ||. |||.|||  ..  |.|||. .| |.||| .|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

DDTE----IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPpSAGPLV
. ..    ..  ..|.|.... | ..|.|..||..                     | ||. ...|. ||||||| .|. || ||..|..    .|||.|
esknkklkvsnrlevellkvqkldgfvvralavkd.................sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPiv

VHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|||||| ||.| .|.||..|.. ||.  .|. . ||.|| .|  .|||..||.|.. ||||.
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 924-1234 4.2e-63 208.1 In-house 21-273 (392) alignment
Range on Protein: 924-1234
Range on HMM: 21-273/392.0
GFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
 | ||.  . . .  |  .|.|. |  ||||.||. || .||.|. |.  ..|||.|  ||....  . |||.|||   .. ||||||..||...|.|||
lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

NLVEVGrvkcckywpddteiykdikvtlietellaeyvirtfavekggaggeancspsrevsqrGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK
.| |                                                              .. | . ||||| |||..|| |.. || |...||
klkegd..........................................................kgddartvaqfhftewPdkdvpkhtssllkfikevk

SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK-LDPQ
..    . ||..||||| ||||  | || ..  |..  .||..| | ..| .|  ||||.||| ||. |.||  |  .| .|  ..     |..   | .
adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGd

TNSSQIKeEFRT
..| |.| |||.
vrskqlk.efrs

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1249-1493 1.1e-62 206.5 In-house 3-244 (250) alignment
Range on Protein: 1249-1493
Range on HMM: 3-244/250.0
IALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD-PAQLCPQYWPENGV
.|  |.|.|||| .||.. | .   | . .  . |.||||. ...|.. .|||.||.||..|..||||.||... ...|||...    . ..|||| .. 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

HRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISI
...| ..|.  | .   |...| . . .| .   . |.|.|..|. ||  .  |   .. |.|...| . |..   |..  .|.| .| ||||.|.||. 
ekyGdvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPd.kgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaida

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
| | |.....||||. .|.||...|..|. |.|| |.||..|..|.|
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPN1_pd Subfamily PTPN1 937-1204 2.7e-62 205.1 In-house 21-280 (290) alignment
Range on Protein: 937-1204
Range on HMM: 21-280/290.0
SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKY
  |  .||..||| .||| ..  |||||..|.  .     |||| . ..  .   .|| ||||. .|.  ||.|||.... ...|. ..|| ...|| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDDTE----IYK--DIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS--PP
|| . |    ...   .||.||..|   .|..|.. .|.                 .  .| ||| .||.| ||| |||   . .| |. .|..     .
wPqgeeekellledtklkvkliseerksyytvrllelen.................lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE--ACLCGDTSV
  || |.||||| ||.| |...| .|   |...    ||| . . |||. |. ..|| .|  | . ||||   .. ||.||
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1250-1494 2.8e-62 205.6 In-house 41-283 (318) alignment
Range on Protein: 1250-1494
Range on HMM: 41-283/318.0
ALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGV
.| | |. ||| ..||. |..   | ...|| .|.||||  .| |..  |.| .| |||.|..||||.| . ... .||| ..     . . .|||..| 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

HRHGPIQVEFVSADLEEDIISRIFRIYNaaRPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISI
. .| ..||  .    .| . | |.. .  . ..  |.|.|...  ||  ...| |  |.|.|.|||.|.|..   |.| .||||  | || |.|.|..|
rsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpd.egvpesgaslldlvrqvskaqqks..gagpivvhCsaGvGrtGvfiavdi

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
. | .... .||||. ||.||.... ||   |||.|.|.| ||.|.||
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1212-1494 3.2e-62 205.5 In-house 10-286 (319) alignment
Range on Protein: 1212-1494
Range on HMM: 10-286/319.0
LYYDMNKLDPqTNSSQIKEEFRTLNMVTPTlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTV
|   ...|.  | . ....||..|.. ...    . . |  ..|..|||  .||. ||.   | ..|| |.|.||||. .|.|.. ..|| || || ||.
Lkerlkalas.tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

KDFWRLVLDYHCTSVVMLNDV-DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIyNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLK
.||||.| ....  ||||... .. .. . .||||. ... | . |.  . .  ||.| | . . | .  .   |.|..||.. ||   | | . .| |.
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpd.hdvPekatslld

LIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
|.... | .|.    .|  |||| .| || |||...... | .... ..|||. |..||  .. ||.  .||||.||. ||....|
llkrirksrekt..qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_PTPRA_pd Subfamily PTPRA 1225-1491 3.9e-62 205.0 In-house 31-295 (330) alignment
Range on Protein: 1225-1491
Range on HMM: 31-295/330.0
SSQIKEEFRTLNMVTptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
. ...||| .|   .       . .|    |.|||| ..||| |    .| ...|. .|.||||. .| ||.   || .| |. .||.||||.. ... .
nklfreefnalPagp...iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksa

SVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--ARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEE
..||| ...    . | ||||..|.  .| |.||     . .|.  | | . .   |. ..  |.|.|| | .||     |.  .  |||...| | .. 
tivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqq

YNGgegRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
. |     ||||  | ||.|||.... | |... .| ||||..|| ||...|.||  . ||.|.|.| ||| 
sag...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 947-1195 6.2e-62 204.0 In-house 19-262 (270) alignment
Range on Protein: 947-1195
Range on HMM: 19-262/270.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDdteiyk
 ..  ||| .|.   ..||||...| | .. ||| ||. |.. ....|||..||.. |. .||||.|.|.. .|.|.|.|.| || || .|||       
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa......

dikvT------LietellAEYVIRTFAVEKGGAGGeaNCSPSREVSQRGvhEIREIRQFHFTGWPDHGVPYHAT------GLLGFVRQVKS--KSPPSAG
           |      ..  |...|...  . |        .. ..|  |.|..  |... ||||||| ..        ||  .|.|.   |.   |.
....epkekvkl......edgkikvlalseekeeg..yiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||.|||||| ||||..|..||.. . |... ||. . ..|||  |...||. ||| |.. |..|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0037934 (Phosphotyrosine protein) phosphatases II 1246-1491 1.2e-61 203.7 In-house 1-242 (243) alignment
Range on Protein: 1246-1491
Range on HMM: 1-242/243.0
DCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGesSNYINAALMDSYKQpsaFIVTQHPLPNTVKD----FWRLVLDYHCTSVVMLNDVD--PAQLCPQ
..|||||| |..||| .|||| |.   .|   .|  |.|||| |.. ...   .|.||.|||.||.|    |||.. ....|..|||.. .   .. |.|
sfsiallpenlsknrysdilpydhsrvkl...eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPeNGVhRHGPIQVEFVSADLEEDIISRIFRIYNaARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEE-----YNGGEGRTVVHCLNG
||| ..| ..|...|...|    .|.. | ....|   ..| .|.|.....|.||   ..| |  ..|.....| ...||     .. ..|...|||  |
ywp.gev.tygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

GGRSGTFCAISIVCEMLrhqrTVDVFHAVKTLRNNKPN-MVDLLDQYKFCYEVALEYL
 ||.||..|. .....|    .||...|||.||. .|. .|  ..||.|.||..||.|
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1217-1489 7.1e-59 194.7 In-house 25-289 (319) alignment
Range on Protein: 1217-1489
Range on HMM: 25-289/319.0
NKLDPQTNSSQIKEEFRTLNMVTPTLrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR
|| | . . .... ||| .  ... |   | . | |..| .||| ..||. |.    |  ..| | |.||||. .. |...  .| .| ||.||..||||
nksdfdddltklevefrracklgvnl..adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

LVLDYHCTSVVMLNdvdpAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDK
.. .|.|...|.|      . | |||| ..| ...  .|.  | .  .. . | ... . .. . . | ..|| ||||| .   | .   ...|...| .
miweyncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdv.Gvpdypsdlmrlvkkvrh

WQEEYNGgEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
 ..  |. .   ||||  | ||.|.. .. .. ....... |||.. |. ||......|. | ||||.|   ||
ltskenh.ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1222-1489 1.2e-58 193.5 In-house 17-277 (288) alignment
Range on Protein: 1222-1489
Range on HMM: 17-277/288.0
QTNSSQIKEEFRTLnmvTPTLRVEDCSIALLPRNHEKNRCMDILPPDrCLPFLITI--DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD
..| ....||...|   ..  . .. ... |..|..|||  .||| |   .  ..   ......||||. .|..|.  ..| || ||..||.|||.|| .
arnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YHCTSVVMLNDV--DPAQLCPQYWPENGV-HRHGPIQVEFVSADLEEDIISRIFRIYnaarPQDGYRMVQQFQFLGWPMYRdTPVSKRSFLKLIRQVDKW
.. . .|||...  .  . | .|||...  ...| ..|. |.   .||.. | . .      . . . ..|.|.|.||     | ||. .|.|.|||.  
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhg.vPeskapllellrqvkva

QEEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
...     |. .||| .| ||.||| |.  . ...... ..||. .|. ||......|. | || |.||| |.
nqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Ptp69D_pd Subfamily Ptp69D 1213-1492 9.4e-58 190.7 In-house 10-287 (307) alignment
Range on Protein: 1213-1492
Range on HMM: 10-287/307.0
YYDMNKLDPQTNSSQIKeEFRTLNMVtptLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVK
  .... . .|.   .| |...|.         .....    |  |||  || . |.    | .| | |.|.||||  . .||.   ||. | |. .|..
eealksrkrdtdfglak.eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatig

DFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAAR---PQDGYRMVQQFQFLGWPmYRDTPVSKRSF
||||.. . . | .||| ...  .   |..|||..   ..| | |..|| .  .| | | . . .        .  | | |....||.     | . |. 
DfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargl

LKLIRQVDKWQEEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
||||.|| . ..     ..  |||| .| ||||.| |.... . |.   .||.|. || ||.... .|. |.||.|.|   |.| .
lklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1241-1494 3.2e-57 189.1 In-house 34-291 (325) alignment
Range on Protein: 1241-1494
Range on HMM: 34-291/325.0
TLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QLCP
.       .| .| | .|||  .... |.  . | |  |  ||.||||. . ..|.   |. .| ||..|..|.||||||..|. ||.|| .|   . | 
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrca

QYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFRIynaARPQDG-YRMVQQFQFLGWP--MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLN
.|||..     . |...|......   | . |.. .    ....|  | |.|||. .|.    .  | .  |.|.|. .|..       . .  .||| .
vywpkemgksktfGglevklrtieeisdyvhrvldv...kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
| ||.|.| ..  . . . ..  ||.|  || ||...|.||.  ||| ..||   |.. ||
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1244-1489 1.2e-56 187.3 In-house 14-253 (284) alignment
Range on Protein: 1244-1489
Range on HMM: 14-253/284.0
VEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNdvdpAQLCPQYWP
  | . | |..| .||| ..||. |.    |  ..| | |.||||. .  |...  .| || ||.||..||||.. .|.|...|.|      . | ||||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcsqywp

ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFC
 ..| ...  .|.  | .  |. . | ... . .. . . | ..|| ||||| .   | .   ...|...| . ..  |. .   ||||  | ||.|.. 
lkivikeerfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdv.gvpdypsdlmrlvkkvrhltskenh.ranivvhcsagvgrtgvyi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
.. .. ....... |||.. |. ||......|. | ||||.|   ||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 934-1194 5e-56 184.6 In-house 24-274 (287) alignment
Range on Protein: 934-1194
Range on HMM: 24-274/287.0
EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVrLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKC
|. .| . .|..  .  ||||.... .|..|| | . ||.  ||||| ||. .|.. . .||.|||.  |. ||||.|.....||.|..|  || .| ||
esstatfkaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

CKYWPDDtEIYK---DIKVTLIE-TELLAEYVIRTFAVekggaggeancspsrevSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV-----KS
 ||||.  |         |.|.. . .  || .|.. .                  .   .| | ..|...  |||....  | ||. || .|      .
ykywPer.evPmrvGGysvvlldydikePeygvralrl.................idletrearvvkqldllswPdkvlaPtavglirfvldvkqhiela

KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
..   .||||||...|.||.| .. . ..... |  | ||. . |  || .|  .||.  |. .. .|. 
rdasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 939-1209 8.1e-56 184.0 In-house 24-278 (283) alignment
Range on Protein: 939-1209
Range on HMM: 24-278/283.0
PWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsDYINGNYID---GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
. | |  |||. |||. .|...|  ||.|..       ||||  .|     |.. . ||..|.|...|. |||.||..|. ..|.|.|.| |  |.||..
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqR----GVHeireIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSA
||| . .| | .  ||| .      ..|. . . .                       .     .  . . .| . |       |. | . .  .     
yWPkrGsedyGeftvtlrkettsnsfiikelllrvn................ssakstll....lahyqvidWleygeqaiinslvkfnkvislqteskk

GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQV
||.|||||.| |||. || .   .. |  | |||... |. .| .|. .||| .|| ..|...|| .||||| . | ..
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1224-1494 2e-55 183.1 In-house 20-286 (305) alignment
Range on Protein: 1224-1494
Range on HMM: 20-286/305.0
NSSQIKEEFRTLNMVtPtlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC
...........| .  .    | . .     |..|||  .| . |     | . . .  |.||||. .|.||.  ..||.| ||.|||.|||||..... 
sdkgleaqykslyee.e....esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

TSVVMLNDV--DPAQLCPQYWPENGVH--RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQE
...||| ..  .  . | |||||.  .  ..|...||  |    .| | | ..| ..   ..  | | |.|.  ||     | .  |.|.||..| | |.
stivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededke.srtvlqyqltdWPd.hGvpqfatsllslikrvqkdqk

EynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
.  . .   .||| .| ||.|.|.|..|  | |..  .||||. .|.||.....||  |||| |....  |....|
k..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0051429 (Phosphotyrosine protein) phosphatases II 976-1209 3.3e-55 182.9 In-house 4-236 (272) alignment
Range on Protein: 976-1209
Range on HMM: 4-236/272.0
SDYINGNYIDGYHR---PNHYIATQGPMQETIYDFWRMvWHENTASIIMVTNLVEVGRVKCCKYWP-------------DDTEIYKDIKVTLIETELLAE
|.||| ....||.|   |. .....||.. |. ||||. ....  .|.......|.||.|| .|||             . |  | .. |||...|||  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHAtgLLGFVRQVKSksppsAGPLVVHCSAGAGRTGCFIVIDIMLDMAER
|..|.. ...                    .|.||....|.|.|||||||..|  || ..... .      ||..|||||| .|||........|   ..
yilrellltllls................agearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsl

EGVVD--------IYNCVRELRSRRVNMVQTEEQYVFIHDAILEAcLCGDTSVPASQV
| .||        ....|.|||..| ..|||||||.|...|.||. |.. .||.|. .
etivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyl

subfamily_PTPN14_pd Subfamily PTPN14 909-1194 3.6e-55 182.1 In-house 10-293 (300) alignment
Range on Protein: 909-1194
Range on HMM: 10-293/300.0
DLLQHITQMKCAEGYGFKeEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEgDTNSDYINGNYIDGY--HRPNHYIATQGPMQETIY
| . .| ..|  ||  |. |||   .  . |  ..|| .||  |||. ... |...||.|.. . .....|||   |      .  .||..|||.. |. 
dkrakilekkleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvq

DFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiyKDIKVTLIETELLAEYVIRTFAVekggaggeanCSPSREVSQRGVHEIREIRQFHFTGWPD
|||.||| .... |.|.|.  | |. |. ||.|....  |  .|.  . .. ....  . .|             . ..     .| |..  . .| |||
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles..kkktvefgkfkvttkfsedsdsv..........ittglklkhlpskeertvwhlqytDWpd

HGVPYHATGLLGFVRQVKSKS---P------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
||||   .| | ....|.|             |  |..||||||.||||  |. |...   | . ..|| . .. || .|  .|||  || |......
hgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

0041856 (Phosphotyrosine protein) phosphatases II 948-1202 5.9e-55 181.0 In-house 1-176 (182) alignment
Range on Protein: 948-1202
Range on HMM: 1-176/182.0
NRMKNRYGNIIAYDHSRvrlqtiegdtNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgrvkCCKYWPDDTeiykdi
|. |||| .|. |||||          ..|||| |...|.......||||||...|..||.||.....  .|...|         .. |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

kvtlietellaeyvirtfavekggaggeancspsrevsqrgvheIREIRQFHFTGWPDHGVPYhATGLLGFVRQVKSksppSAGPLVVHCSAGAGRTGCF
                                             |.. |.....|||||||     || |...|..    . || .|||||| ||||..
............................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtl

IVIDIMLDMaereGvVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
.....|. .    | |.....|...|||| .||.|..||.|...|.|| .|...|
vaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1250-1491 1.7e-54 179.9 In-house 44-279 (315) alignment
Range on Protein: 1250-1491
Range on HMM: 44-279/315.0
ALLPRNHEKNRCMDILPPDRCLPFL-ITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENGV
|    |..||| ..|.. |.  ..| ..   . |.|.||...| |...  .| .| |....|||||||| ..... .|||...     . . .|||.. |
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkv

hRHGPIQVEFVSADLEEDIISRIFriynAARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISI
  .|.| |  .| . ....  | .    .   .|  | | |...  ||   . | .  ....|||.| .....     |  |||| .| ||.|||.... 
.iyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitlda

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
| . .  .. .||..... .|.|. .||. ..||.| |.. || .
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1254-1493 2.9e-54 179.2 In-house 50-286 (297) alignment
Range on Protein: 1254-1493
Range on HMM: 50-286/297.0
RNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQpsAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QLCPQYWPENGVHRHGP
 | ||.|  .||| |.    |  .. . .|.|.||. . ..|.   .| || | ..||.|||..|||.. . .||||| .   . | .||...||   | 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGd

IQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRDTP-VSKRSFLKLIRQVDKWQEEYNGGegRTVVHCLNGGGRSGTFCAISIVCEM
. |.  | .  |  | | . . . .      |.|.|.||. ||        | .|.|||| .| |  .. . |    .||||.| || | ...|  |   
vsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvae

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 ... .||.|  || ||...|..|   .|||| |.. ||.| |
akrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_PTPRN_pd Subfamily PTPRN 936-1195 1.7e-53 176.3 In-house 44-290 (297) alignment
Range on Protein: 936-1195
Range on HMM: 44-290/297.0
QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI-DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC
. .  . ||...|  |||. ....||||||.|..   ...|||||   | |   |   |||||||. .|. |||.|||.. .. |...|.| | |  .| 
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

KYWPDD-TEIYKDIKVTLIETELLA-EYVIRTFAVEkggaggeaNcspsreVSqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGP
.||||. .|.|.  .| |.   . . .|..|.| .         |      .     .| | . ||||  ||..|||  |  || | |.|       . |
rywpdeGsevyhiyevhlvsehiwcddylvrsfylk........n......lq...tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

LVVHCSAGAGRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
.|||||.||||||..|.||..|.        .||   .  || .| ..|.|..|. |.  |. |
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1216-1493 1.7e-53 176.5 In-house 10-280 (287) alignment
Range on Protein: 1216-1493
Range on HMM: 10-280/287.0
MNKLDPQTNSSQIKEEFRTLNMVTptLRVEDCSIALLPRNHEKNRCMDILPPDRclpFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR
. . ...... . |. | .|. ||   | ..  ... ..|..|||  .||.||    . . . ||  .||||. .|.||.  |||... |. ||...||.
fvakghakgnegfknqftvleqvt..qredevthniasqnkdknRltqilvpdn...yrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWk

LVLDYHCTSVVMLND--VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRqv
|. | . | .||| .   .  . | |||||.     |. ..|... . ... | | ... |  . .|  ..|.|.|.  |.  .. .  . ..| . .  
liddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqtillviee..

dKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 . ....  |..  |||| .. |||..|||. .  .  . . ..|||  .|  |  ||..|   .|||| ... ||||.|
.myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_PTPN9_pd Subfamily PTPN9 1228-1491 9.4e-53 174.2 In-house 18-290 (297) alignment
Range on Protein: 1228-1491
Range on HMM: 18-290/297.0
IKEEFRTLNMVTPTLRVedcSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVV
...|.  .   ... ..     . |. | ||||  |.|  |.   .| ..|. | |.||||  .| |||. ||| || ||..||.||||.| . ..  .|
lskeyaeirnepveGtf...lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLNDVDPA--QLCPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY--
|   |       | ||||  |. ....| ..|. |. . |||   |.. |.|.    .  | |  ||||.|| |  .| |  |.|.....| . |     
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdy.GvPssaaslldvlekvrekqalavk

--------NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
        .  .   ||||  | ||.|||... |  . |... ||||...||.||. .  ..   .||.|||   ||| 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_PTPRG_pd Subfamily PTPRG 1226-1493 1.6e-52 173.5 In-house 19-289 (563) alignment
Range on Protein: 1226-1493
Range on HMM: 19-289/563.0
SQIKEEFRTLNMVTPTLRVeDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSN--YINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
  ..|||  |.. | .  . |.. .  | |..||| ..|.. ||    |  . |. ..  ||||  .| |..  |||.||.||..|..||||.. . . .
igfseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

SVVMLND--VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYN---AARPQ-DGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQ
 .||. .   . .. |..|||.... . | .||  .. .      .| . | |    .  | |  ..|.|...  ||   ..| ..   |. ... .. .
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd.hgvPehslpvLifvkkssaan

EEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
..     | .|||| .|.||.||..... . . .... .|.||. .|..| .....|   .|| | ... || ..|
kae...aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1254-1492 2.2e-52 172.8 In-house 42-277 (515) alignment
Range on Protein: 1254-1492
Range on HMM: 42-277/515.0
RNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QL-CPQYWPE--NGVHR
 |..|||  .||| |.    |  | |   |.|.||. . |..   |.| .| |.. .|.|||||||... | ..|...     .  | .|||.      .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

HGPIQVEFVSADLEEDIISRIFRIYnaaRPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISIVC
 | |.|| || .   . | | ...    . .| .| | ||.| .||  . .|   .|.||||..|   ...|.      ..||. | || | ...|  | 
fGsikvelvsleactggikrkltvl...kgdd.srtvtqfhfteWPd.kGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvv

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
   .  |.||||. |. .|...| .|   .|| | |.. ||.| 
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1250-1492 6.4e-52 171.3 In-house 39-278 (315) alignment
Range on Protein: 1250-1492
Range on HMM: 39-278/315.0
ALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPE--N
|  . |..|||  .||| |.    |  ||    |.||||. . |...  |.| .| ||. .|.||||.||... |..||... .      | ||||.   
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

GVHRHGPIQVEFVSADLEEDIISRIFriynAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeYNGGEGRTVVHCLNGGGRSGTFCAI
   . | |.|| .| .   | . | .      |  . .| | |||| .||  . ..    |.||||..|       .  |   .|||. | ||.| ...|
dsvefGsikvellsleadtdgvarkl....vtrkseesrtvtqfqftewPd.kGvdkqtssllklikevkad...ngkkefsllvhcsaGvGrtGvvisi

SIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
  | . ....|.||||. ||.||...| .|   ..| | |.. ||.| 
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPN23_pd Subfamily PTPN23 947-1196 7.5e-52 170.9 In-house 42-279 (288) alignment
Range on Protein: 947-1196
Range on HMM: 42-279/288.0
ENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTE
 .  |||. .|. |||.|| |.    ... ||||  .. .      ..||||.|.|.|. |||.||... .  |.|...  | |. |. .|||    .|.
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS----KSPPSAGPLVVHCS
 ..|..||| ... . ..| |.. .|                  ..........  ..| ||..|||     || |. .|.|    .  .|  |||||||
kfgdlsvtlksvretethvervlklet.................ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCs

AGAGRTGCFIV-IDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|| |||| | . . .. .. ...|..|| . |. ||  | .|||..||. |  .|.|||
aGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_PTPRB_pd Subfamily PTPRB 1222-1492 1.6e-50 166.8 In-house 21-286 (293) alignment
Range on Protein: 1222-1492
Range on HMM: 21-286/293.0
QTNSSQIKEEFRTLNMVTptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDY
. .  ...||. .|. |    . . ...| |..|..|||  .||| |     | .... ..|.||||  .. |..|  ||.|| |||.||.||||.|.. 
adsdlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwek

HCTSVVMLNDVDP--AQLCPQYWPEN-GVHRHGPIQVEFVSADLEEDIISRIFRIYNaarpQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQ
... .||| ..     . | .|||..   . .| |.|..|. .  || . | ..| .    ..  | |.|..|. || . . | . ...|...|.|....
kssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdh.gvPektktlldfvrtvreai

EEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. .  .. .||||  | ||.||| |.  . . .... .||.|  |  ||... ..|   .|| | ... |..|.
ekta.skrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

0036282 (Phosphotyrosine protein) phosphatases II 976-1191 1.7e-49 163.2 In-house 2-164 (174) alignment
Range on Protein: 976-1191
Range on HMM: 2-164/174.0
SDYINGNYIDGYHRPNHYIATQGPMQetiydFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDdteiykdikvtlietellaeyvirtfavekggagge
||||| ...|........||.|||..     ||.|.....  ...|.....| |..||. |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATgLLGFVRQVKSKSPP-SAGPLVVHCSAGAGRTGCFIVIDIMLDMAErEGVVDIYNCVRELRS
           .  .. |.. |.....|||||||  .. || ||..|..     . ||..|||||| ||||.......|| . . |..||... |||||.
...........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRl

RRVNMVQTEEQYVFIHD
 | .||||..|| |...
qrpgmvqtpsQyrflyy

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1224-1493 3.7e-49 162.2 In-house 18-285 (290) alignment
Range on Protein: 1224-1493
Range on HMM: 18-285/290.0
NSSQIKEEFRTLNMvtpTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE---SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDY
. .. ...| .|.    . . .   ..| . |...||  .|...|     |  | |.   . .||||. .. ||.  ..|.|| |..||..|||.|. . 
gnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

HCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqDGYRMVQQFQFLGWPMYRDTPVSKRSfLKLIRQVDKwqE
..| .||| ..     . | ||||...... |..... ..    ...| | ... |     .  ..|.|.|.  |.   . .  . . | .|... |   
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqti.llvieemyk..t

EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
..  |..  |||| .. |||..|||. .  .  . .  .|||. .|..|  ||..|   .||.. ... |.||.|
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN12_pd Subfamily PTPN12 1223-1492 1.5e-48 160.2 In-house 5-278 (290) alignment
Range on Protein: 1223-1492
Range on HMM: 5-278/290.0
TNSSQIKEEFRTLNMVTPTLRVED---CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVL
... . ..|| .| ...  .. |.    . .  ..| .|||  |||| |     | .|..|  |.|||| ..   ... ..| .| |||.|..||||.. 
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYHCTSVVML-NDVDPA-QLCPQYWPENGVHRH--GPIQVEFVSADLE-EDIISRIFRIYNAarpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQV
... . |||. . |. . . | .||||.| ..   |...|.  . .   .|.. | ... .     .  |.|.||..  ||  ...| |. | |.||..|
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPD.hgvPssaksllelielv

DKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 . ||     .   ||||  | || || .|| .| |.|.....   .|||. | .||.... .|   .||.. |.  .|...
relqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 947-1196 2.5e-46 153.1 In-house 40-276 (307) alignment
Range on Protein: 947-1196
Range on HMM: 40-276/307.0
ENRMKNRYGNIIAYDHSRVRLQTiEGdTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDtEIYKD
 |  |||| .. . |..|. ... .|   ||||  ||.    .|...|..|||...|.|.|| |.  |.  |.||. ...|....|| .||| . |  | 
antdknryqdvkcqdkgrivvkf.dg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple.egqkl

IKVTLIETELLAEYVIRTFAVEKggaggeaNCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGC
. .   .|  .|.  ....| ..       ..    ..     .. | |... .. |||.|||    . . ..  |. .      |.||||||| ||.| 
vfgeapntisvanlgakklapde.......dlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....npvvvhcsaGvGrsGt

FIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
 . | .. | | . .   |. . |.||||.|   .||| ||...|  .|| 
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

0046846 (Phosphotyrosine protein) phosphatases II 966-1194 7.6e-46 151.4 In-house 2-170 (176) alignment
Range on Protein: 966-1194
Range on HMM: 2-170/176.0
RLQTIEGDTNSDYINGNYIDGYhrpnHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKdikvtlietellaeyvirtf
||. .  | ..||||.|.|.|.    ..||||||. .|..||..|.....   ....|..|| ||.||. |||. ..                       
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

avekggaggeancspsrevsqrgvheireirQFHFTGWPDHGVPYHaTGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDimldMAEREGVVDI
                               |.....||||||| . . || .......      || .|||||| ||||......    . |.|  ...
...............................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsv

YNCVRELRSRRV-NMVQTEEQYVFIHDAIL
.......|..|  ..|||.||| |.....|
eealalvreqRplgavqtpeQyrflyefel

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1251-1491 1.6e-45 150.4 In-house 24-268 (274) alignment
Range on Protein: 1251-1491
Range on HMM: 24-268/274.0
LLPRNHEKNRCMDILPPDRCLPFLITIDGE--SSNYINAALMDSYKQ-PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENG
 ......|||  .||| ..    | . ..|   |.||||  .  |..   |.. || ||||||.||||..   ... .||| ..  |.   | .|.|.. 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

VH----RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgyrmVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTF
      |.| ........  ..|   | . . .. |...    |. . .  ||  ...| . ...|.|...|.. .|| |   . .||||  | || | |
dyeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPd.hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 |||| .  ||.. .|||.. |  || ..  ||.  .||.. ...  .||
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_PTPN6_pd Subfamily PTPN6 1204-1492 1.8e-45 150.2 In-house 4-298 (306) alignment
Range on Protein: 1204-1492
Range on HMM: 4-298/306.0
VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTpTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMD--SYKQPSAFIV
. |.....   ...| . ... . ..||| .|.    . .. . . .  |.|.||||   ||| |     |   .   |.||||  ..  . ..  ..| 
llakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyia

TQHPLPNTVKDFWRLVLDYHCTSVVML-NDVDP-AQLCPQYWPENGV-HRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRD
||  |..||.||||.|.. ... .||. ..|.   . | .|||..   ...| |.|. || .  .| | | ... .  . ..  | | |..|  ||   .
tqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkke.erevfqyhfksWPd.hg

TPVSKRSFLKLIRQVDKWQEEYN-GGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
.| ..  .|.....|.. ||| .   .| .|||| .| || |||  | |. ......     .|. ..||..|. .  .|   .|||| |..  .|..
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

0043147 (Phosphotyrosine protein) phosphatases II 973-1190 2e-45 149.9 In-house 2-154 (172) alignment
Range on Protein: 973-1190
Range on HMM: 2-154/172.0
DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLvevgrvkcckywpddteiykdikvtlietellaeyvirtfavekgga
| .||||| .|.|.|. |...||||||...|. |||||.....   |...|.|                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

ggeancspsrevSQRGVHEIREIRQFHFTGWPDHGVPyHATGLLGFVRQVKS-KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLdmaereG-VvDIYNCVR
               . .. |.. |.....||||||| ..  || |......     . || .|||||| ||||.......||        . .....|.
............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeava

ELRSRRVNMVQTEEQYVFIH
..|..| ..||...|| |..
lvrekRpgavqnpsqyrfly

0049772 (Phosphotyrosine protein) phosphatases II 942-1197 8.6e-45 149.1 In-house 40-280 (314) alignment
Range on Protein: 942-1197
Range on HMM: 40-280/314.0
SAKKDENRMKNRYGNIIAYDhSRVRLQTIEGDTnSDYINGNYIDGYhrpNHYIATQGPMQETIYDF----------WRMV--WHENTASIIM--------
 |.. .|| |||| .|. .| .||.|.. .... ||||| .|.||.   . .||||||...|..||          ||||  .  |.  | |        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------VTNLVEVGrvkcCKYWPDDTEIYKdikvtlietellaeyvirtfavekggaggeancspsrEVSQRGVHEIREIRQFHFTGWPDHGV
              ..| . |    . ... | | .|                                     |.   . .  |.. ... . .||...
elsrLdaAlgKtpllildgng....neptaadlellk.....................................eelydpelferlgikylripvpDgsa

PyHATGLLGFVRQVKSKspPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAereGVvDIYNCVRELRSRRV-----NMVQTEEQYVFIHDAILEAC
|     .. |.. ...   .  ||..|||.|| ||||.|.|.....      || ..  .....|..|      ..... |||.||..|.||..
p.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1244-1490 1.9e-44 146.6 In-house 22-265 (283) alignment
Range on Protein: 1244-1490
Range on HMM: 22-265/283.0
VEDCSIALLPRNHEKNRCMDILPPDRclpFLITIDGESSNYINAALMD---SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCP
  |. ||   .|..|||  .|.| |.   . . .. || .||||. .    ||||   .|..| || .||.|||..| | . |..|||  .  |  . | 
dldadiasadenkrknrnqeivpadq...wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRmVQQFQFLGWPMYRDTPVSKrSFLKLiRQVDKWQEEYNggEGRTVVHCLNGGGRS
||||..|   .|.  |       ..  | . . . . .  ..    .  .|. .|  | . ..   |..|.  .|   | | .  .|  |||| .|.||.
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiin.slvkf.nkvislqtesk..kgPivvhCstgiGrt

GTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
..|.|.|   . .. .  ||||  || .|.... .|  |||||. .|..|| 
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 928-1195 2.7e-44 146.2 In-house 12-293 (297) alignment
Range on Protein: 928-1195
Range on HMM: 12-293/297.0
EYESFF-EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTieGDTNSDYINGNYIDGY--HRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
|..... | ..  . |||..    |||| .|.|.| .||.|.   . |..|||| .|.     . . .|| .|||...|. |||..|....   |.||..
ekdllldeargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

LVEVGRVKCCKYWPDDTEiyKdikvTLIETELLAEYVIRTfavekggaGGEANCS--PSREVSQRgvHEIREIRQFHFTGWPDHGVP--------Y----
| | || ||  |||.  .  .     |  .... |.. .|          | .       ..  |   | | .|   | .|||||||        .    
lqedGrdkcapywpsvvq..e....rlkagdvvveflsst........sdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv

-----HATGLLGFVR--------QVKSK--SPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
         .|. |         |..|     |   .|.|||||| ||.|  .  |..|..  .. . |.   .. ||..|  .||| ||. ...||.|.
cscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk





0041856 (Phosphotyrosine protein) phosphatases II 1255-1492 3.8e-44 145.8 In-house 1-172 (182) alignment
Range on Protein: 1255-1492
Range on HMM: 1-172/182.0
NHEKNRCMDILPPDRCLpflitidgeSSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNdvdpaqlCPQYWPengvhrhgpiqv
|..||| .||||.|. .          ..|||| |....  .. ||.||.||..|| ||.|.. ....|..|.|.       ...|||            
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp............

efvsadleediisrifriynaarpQDGYRMVQQFQFLGWPMYRDTPvsKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMlrhq
                        .. .|.. |...|.|| .  ..   ...|..|..| .        .|...|||  | ||.||..|. .....    
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....

rTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
  |....|||..|. .|.||  ..|| |.. ..||.| 
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1227-1492 2e-43 143.5 In-house 16-277 (281) alignment
Range on Protein: 1227-1492
Range on HMM: 16-277/281.0
QIKEEFRTLNMVTptlrVEDCSIA-LLPRNHEKNRCMDILPPDRCLPFLIT-IDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
  .||...|. .     |.. . |   . | .||| ..|   |     .    . ....||||  ...||.. ..|.|| |.|.....||..|.... . 
Gfieeyeklaaig....vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

VVML-NDVDPAQL-CPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIynaARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYN
.||. ....  .| | .|||..    . | ..|.....  ..  |.| |..    | .   | |.|.... ||     | . . .|.  ..| | .|. .
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPd.hGvPattkellefrkevlkltekkt

GgeGRTVVHCLNGGGRSGTFCAISIVCEML-RHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
      |.||  | ||.||. |.  ... . ......||   |. ||...  ||  . ||.| | . |..|.
k..aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_ptpA1_pd Subfamily ptpA1 924-1155 6e-43 142.1 In-house 22-254 (418) alignment
Range on Protein: 924-1155
Range on HMM: 22-254/418.0
GFKEEYESFfEGQSAPWDS--AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHrPNHYIATQGPMQETIYDFWRMVWHENTASIIM
  |||.  . |    | ..    |  |  |||| ||.  .|.||.|. |.    ||||| ||||| . |...|.||||. .|| ||||||| .    |.|
kikeefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivm

VTNLVEVGRVKCCKYWPDDTEIyKDIKVTLIETELLAEYVIRTFavekggaggEANCSPSREVSQR-----GVHEIREIRQFHFTGWPDHGVPYHATGLL
..   |  |.|| .|||..    ... .     |..  | .            |    | ||.  |        | |.| |... ||||| .| |.  . 
lsresencrikcdrywpeqigg.eqfsiygngnevfgtysvelv.........eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr

GFVRQV---KSKSPPS---AGPLVVHCSAGAGRTGCFIVIDIMLD
 ... .   . .  ||     |..|||||| |||| |    ||. 
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 946-1195 2.5e-42 139.5 In-house 52-281 (290) alignment
Range on Protein: 946-1195
Range on HMM: 52-281/290.0
DENR--MKNRYGNIIAYDHSRVRLQtiEGdTNSDYINGNYIDGYHRPnhYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEi
|.|    |||| ...  | .|| |.  .|  . ||.  ||..| . .  .| |||....|. |.|||| .|..| |.|. .|.| |. || .|.|.    
dkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG.

ykdIKVTlietelLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEireIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGR
     .|      . |. .     ..  |    .    |.. .   |    .. ..   |||. |.  .  ||  .| ..  |    ||.||||||| ||
...evlt......fGeitvlcseeddkdaniikktlsvrdkdsGkehk...lkhlkikswpdksvalstlallrtlrilrkas....GpvvvhcsaGiGr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|| |. |.. |..      .|. . || ||  |.| || . ||. . ...|.
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_PTPN23_pd Subfamily PTPN23 1224-1490 3.1e-42 139.4 In-house 13-279 (288) alignment
Range on Protein: 1224-1490
Range on HMM: 13-279/288.0
NSSQIKEEFRTLNMVTPTLrVEDCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPS-AFIVTQHPLPNTVKDFWRLVLDYHC
. ......|. |..       .. |||.  .. ||||  |||| |.     ....|.  .||||. . .    .  ||.|| ||..|. |||..| . . 
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnR...vklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TSVVMLNDVDP-AQ-LCPQYWPENG--VHRHGPIQVEFVSADLEEDIISRIFRIynAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDK-WQ
  .||| . .   .  . .||||.    ...|...|   |    |  . |....    ...|  ..|.  |.  || .   | |  ..|... .|.. ..
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkl..etldadavksvshlqltsWpel.GvPasPetllqfldevesaye

EEYNGGEGRTVVHCLNGGGRSGTFCAI-SIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
.. .  .   ||||. | ||.|.|. . ..| |. ...  .|. . |..||... .||   .|.||.||. ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 942-1197 6.9e-42 138.2 In-house 42-287 (305) alignment
Range on Protein: 942-1197
Range on HMM: 42-287/305.0
SAKKDENRMKNRYGNIIAYDHSRVRLqtiEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT
. |. ... |||| ..   |. ||.|   ||    .||  ||.     |. .| || |...|  ||| | . ..  .|.|. ||.| |  ||..|.. . 
afkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

EIYKDIKvtliETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRqvksKSPPSAGPLVVHCSAGA
.   ...    | .      . . .  |  .  .|. . .  | .   .. | . ..|.  ||| |||   . .| ..     |. || ||.||||||| 
kdvlefe....ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpivvhcsagi

GRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||||  .... .||   . . . |    .. .| .| | .||..||.|.|. ||. .
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_PTPRN_pd Subfamily PTPRN 1224-1490 1.1e-41 137.5 In-house 27-291 (297) alignment
Range on Protein: 1224-1490
Range on HMM: 27-291/297.0
NSSQIKEEFRTLNMVTPTLRVEdcSIALLPRNHEKNRCMDILPPDRCLPFL-ITIDGESSNYINAA-LMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYH
| .....|. .|       ...  ..|  ..| .|||  ..|| |     |  . . |.|.||||. ..|.  . .|.| || ||..|| |||..| .  
nkdrlekewealcayeaepstk..evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

CTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADL-EEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqe
.. .|.|  ..    . | .|||..| . ..  .|..||  .  .| . | | . |     .  | | || || ||  ...| | .|.|.. |.|.|   
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt..setrtvtqfhflswpe.egvPasaksllefrrkvnk...

EYNGGEGRTVVHCLNGGGRSGTFCAISIVCE-MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 | |     |||| .| ||.|....| .|.. .|.  . .|.  ... ||...|..|   ||..|.. .  | 
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_PTPN3_pd Subfamily PTPN3 1216-1488 2.6e-41 136.4 In-house 5-272 (280) alignment
Range on Protein: 1216-1488
Range on HMM: 5-272/280.0
MNKLDPQTNSSQIKEEFRTLNMVTPTLRvedCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMD----SYKQPSAFIVTQHPLPNTVK
. .|  . .| ..  .| .|    | |    .|.| .|.| .|||  |||| |      .... ....||||  ..    | ..   .|.|| ||..|..
llllkeglesGavlaqfeqlyrkkpgla...isaarkpenlsknryrdilpydatr...vklkesetdyinanyvnmeipstglvnryiatqGPlaktat

DFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLK
|||..| . ... .||| ..     . | |||||..   ..| ..|.  . | .. .. | . . ...   .  |.. |.|.| ||   . | .. .||.
dfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket..keerkilqlqylaWpd.hgvPddsadfle

LIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL
....| | .   .| |  .||||  | ||.| . .. .   .. ... | . . |.|.|. . ..|.  .||||  |  |
fvervrklr...sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

0049260 (Phosphotyrosine protein) phosphatases II 983-1191 3.7e-41 135.7 In-house 1-144 (152) alignment
Range on Protein: 983-1191
Range on HMM: 1-144/152.0
YIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWpddteiykdikvtlietellaeyvirtfavekggaggeancspsr
.||||..|...||||||. .|. |||||... .   |.|.|.|.| |..|| .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

evsqrgvheireirQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLdmaereGVVDIYNCVRELRSRRVNMVQT
              |.... ||||||| ..  || ... ..     . || .|||||| ||||.......||        |.....|. .|..| ..|..
..............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn

EEQYVFIHD
..|. |...
pgqlrflye

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 947-1194 6e-41 135.0 In-house 51-287 (310) alignment
Range on Protein: 947-1194
Range on HMM: 51-287/310.0
ENRMKNRYGNIIAYDHSRVRLqTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD--DTEIY
..  |||| ...  | |||.| .|.     |||  ||.   .  . .| .|||.| || |||||.. | . ||... . .| || ||  |||    || |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

KDIKVTLIeTELLAEYVIRTFAVEKGGaggeaNCSPSREVSqRGVHEIReIRQFHFTGWPDHGVPYHATGLLG--FVRQVKsksppsAGPLVVHCSAGAG
  |.|| . .|   |. |  .||         .  |  |     ..|.| .   ..  ||| |||      .   .. ||.       || ||||||| .
gcirvtnl.sesseefeicnlavtfvp.....dnvpvdeqp.anlkelr.vslikwpnwpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkd

RTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
|... . ... .| ..|   ||. . . ||. .|.  .||| ||..|.   .
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1222-1492 3.4e-40 132.6 In-house 11-294 (301) alignment
Range on Protein: 1222-1492
Range on HMM: 11-294/301.0
QTNSSQIKEEFRTLNMVTPtlrvEDCSIALLPRNHEKNRCMDILPPDRC---LPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVL
...| ...|....|. ...    . |.. |  .|.. ||  .| . |     |    ..|  . .||||  .|.|..  .||..| |. .|..|||||..
akhsnkfeeqykelkeged....ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

DYHCTSVVMLNDVDPA--QLCPQYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFR--IY------------NAARPQdGYRMVQQFQFLGWPmyRDTP
... .|.||. . .    . | ||||.     .. ||..|..|.     | . | .   |.            .  . .   . | |.|   ||   |  
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWp..qdGv

V-SKRSFLKLIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|  .|  |. | .| . |     | |  |||| .. .|||..|..||  |  . .  ||||  .|..| .|| .|  |.|| . |.|  .||.
vreprtvLqviddvihrqqki..gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

0049772 (Phosphotyrosine protein) phosphatases II 1213-1492 3.7e-40 134.0 In-house 3-281 (314) alignment
Range on Protein: 1213-1492
Range on HMM: 3-281/314.0
YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVED-CSIALLPRNHEKNRCMDILPPDrCLPFLITIDGESSNYINAALMDSYkqpSAFIVTQHPLPNTVK
.|...... ....... ... .||...... .|  . .| |..|..|||..|||| | .. .| . ....|.||||  .|..    .||.||.||..|| 
ayplasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvv

DF----------WRLVL--DYHCTSVVM---------------------LNDVDPAQlcPQYWPENGVHRHgpiqvefvsadleediisrifriynaAR-
||          ||.||  |...  .||                     |...|. .  .......  . .                           . 
dfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk..........................eel

-----PqdgYRMVQQFQFLGWPMyRDTPvSKRSFLKLIRQVDKWqeeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLrhqrTVDVFHAVKTLRNNKP-
     .    |.. ..  . .|   ..| . . |..... ....       .|...|||  | ||.|||... ...  |     |..  |.. .|.  | 
ydpelf...erlgikylripvpD.gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpi

----NMVDLLDQYKFCYEVALEYLN
    ...  |.|| |..|. ||||.
npnpgfieqleqyefilealleylk

subfamily_PTPN13_pd Subfamily PTPN13 1219-1492 4.6e-40 132.6 In-house 4-270 (273) alignment
Range on Protein: 1219-1492
Range on HMM: 4-270/273.0
LDPQTNSSQIKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSnYINAALMDS--YKQPSAFIVTQHPLPNTVKDFWRL
|  . .. | .|||..|. . |.   ..|...   .|..|||  ..|| |.     .....|.. ||||.|.     |.   .|..| |||.||||||..
lqkkldqqqPaeefkelrelkpl...dtcevgkkkenkdknryrnvlPydetr...vklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VLDYHCTSVVML-NDVDPAQL-CPQYWPENG---VHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIR
| . ... ..|. ....  .. | .||||.    .  .. ..|| .     ..   | . . . .      | |....|  || . ..| |  ..|....
vweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..gesrevahlnfvkwPdh.gvPssaaellqfva

QVDKWQEeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
.| . |.     .|  ||||  | |||||. .| .| ... ... .|| . |..||. .  .|   ||| |.|...|| |.
evrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

MAM MAM domain 27-183 1.8e-39 123.4 Pfam-A 1-159 (160) alignment
Range on Protein: 27-183
Range on HMM: 1-159/160.0
CLFDEPysTCGYSQSEGDDFNWEQVNTLTK-PTSDPWMPS------GSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNsppGLLNVYVK
| |.|   .||.||.| ||..|..|.. |. ... |...       |..|.|..| ..||..|.||.|.|......|..|.|..|....   | |||||.
CdFeee..lCgwsqdetddldWtrvsgstptektgpssdhtlgkesghymyvetssgaegesarllspllpasssaClrFyyhmsgsev...gtLnvyvr

VNNGPLGNPIWNISGDPTRTWNRAELAISTFwPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCT
 ....  ...|.|||. ...|..||...|.. .. .||.||..  .|..|..|.|....  ..|.
eekegeetllweisgnqgssWqeaevtlsai.tkkfqvvfeavrgkgsegdialDdislsegeCs

0036282 (Phosphotyrosine protein) phosphatases II 1282-1485 2.1e-39 130.4 In-house 2-164 (174) alignment
Range on Protein: 1282-1485
Range on HMM: 2-164/174.0
SNYINAALMDSYKQPSAFIVTQHPLPntvkdFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPEngvhrhgpiqvefvsadleediisrifriynaaRPQ
|.||||  .| .  .. .|..|.||.     ||... ....|.||||..  . .  .|..||||                                 ...
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DGYRMVQQFQFLGWPMYRDTPVSKrsFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRhQRTVDVFHAVKTLRNNKPNMVDLLDQ
| .|.. |...|.|| .   ..|.  .|.....|.....|  ...| ..|||  | ||.||..|. ... .|. ...||... |..||. .|.||   .|
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFCYE
|.|.|.
yrflyy

0051429 (Phosphotyrosine protein) phosphatases II 1281-1492 6e-39 129.7 In-house 3-226 (272) alignment
Range on Protein: 1281-1492
Range on HMM: 3-226/272.0
SSNYINAALMDSYKQ---PSAFIVTQHPLPNTVKDFWRLvLDYHCTSVVMLNDVD--PAQLCPQYWP------------ENGVHRHGPIQVEFVSADLEE
 |.||||  .. | .   | ... ...|||.|..|||||  .......|.| ...  ... |..|||            .   ...| . | ..|  | .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DIISRIFRIYNAARPQDGyRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQvdkwqeeynggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVD-----
|.| | .....   .... |.| ......|| .   . . ...|.|...           .|. .|||  | .|.||..|. .. . . ..  ||     
dyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
   ...||. ||   |..|   .||.|.||..||.|.
nlyleeaveelraqrpgavqteeqylflyeallellr

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 945-1195 3.5e-38 125.9 In-house 34-267 (281) alignment
Range on Protein: 945-1195
Range on HMM: 34-267/281.0
KDENRMKNRYGNIIAYDHSRVRLQT-IEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI
.  |  |||| || . | |||.|.  .     .|||  |||        || |||| .||  |||||.|.|||..|.|. ...|  | ||..|.| ..  
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

YKDIkvtlieTELLAEYVIRTfaVEKGGAGGEANCSpsrevsQRGvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSagplVVHCSAGAGR
  ..       .|  .|   |  |.|       | |        |  | | | .. .  |||  ||  .  .|  .|.....| |     |.||||| ||
clqf......dklsvsyedst..vnkslvttrlnls......yeg..etrlithwlwkewpdwqvpessevmlkilrkirarstpp....vihcsagvgr

TGCFIVIDIMLDMAE-REGVVDIYNCVRELRS-RRVNMVQTEEQYVFIHDAILE
.| .. ..| |.    .  . || . |  ||   |   ||| .||..|   .|.
sgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_PTPN14_pd Subfamily PTPN14 1218-1493 4.4e-38 126.0 In-house 15-298 (300) alignment
Range on Protein: 1218-1493
Range on HMM: 15-298/300.0
KLDPQTNSSQIKEEFRTlnmVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSY--KQPSAFIVTQHPLPNTVKDFWR
 |. . .....  |.     ...     ..| | || | ||||  |.|| . .   |..   .|..||||. .      .   .||.| ||..||.|||.
ilekkleegkvfteyer...ipkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWq

LVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVH----RHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKL
.| . . . .||| .   |  . . .|.|... .    ..|  .|     .  . .| . ....    |   .| |  .|.  ||  .. |   ..||. 
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl..pskeertvwhlqytDWpd.hgvPeDvkgflsy

IRQVDKWQEEYNGGE------GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
...|.  ... |            .|||..|.||.|      .. . | |....|. .....||. .  .|. | |||| |.| ..||..
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

0044763 (Phosphotyrosine protein) phosphatases II 960-1195 5.2e-38 125.8 In-house 2-169 (178) alignment
Range on Protein: 960-1195
Range on HMM: 2-169/178.0
YDHSRVRLQTIEGDTNSDYINGNYIDGYhrpnHYIATQGPmqetiYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiykdikvtlietellae
.|..|| |...||   ||||| ..|...     |.....|      |...... ..  .|...|. .| |..||..|||....                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yvirtfavekggaggeancspsrevsqrgvheireiRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMaer
                                     |......||||||     .| ||. ...  ... || .|||||| ||.|.......|. .   
....................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...

eGVvDIYNCVRELRSRRVnMVQTEEQYVFIHDAILE
 |. .........|.||  .|....|. ....  |.
.gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

0051082 (Phosphotyrosine protein) phosphatases II 976-1194 2.7e-37 123.0 In-house 3-150 (151) alignment
Range on Protein: 976-1194
Range on HMM: 3-150/151.0
SDYINGNYIDGYhrpnhYIATQGPMQetiyDFWRMVWHENTASIIMVTNLVEVGrvKCCKYWPDDTeiykdikvtlietellaeyvirtfavekggagge
||||| .|..|.     .....||..    ||........  .|.......| |  .| .|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ancspsrevsqrgvheiREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSkspPSAGPLVVHCSAGAGRTGCFIVIDIMLDMaeregvVDIYNCVRELRSR
                 .|........|||.|.| .   .| |.... .   .. ||..|||||| ||||.......|| .      |... ...|.|..
.................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlk

RVNMVQTEEQYVFIHDAIL
| ..||...|..|.. |.|
rpgvvqpnqqflfqlfall

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 945-1196 2.8e-37 123.0 In-house 52-288 (305) alignment
Range on Protein: 945-1196
Range on HMM: 52-288/305.0
KDENRMKNRYGNIIAYDHSRVRLQTIEgdtNSDYINGNYIDGYHRPN-HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI
 | .  |||| .. . |.| |.|.       ||||  ||.     |.  .|..|||...|| .|| || ...   |.|. . ||.|..||..|||     
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

YKDIKVTlieteLLAEYVIRTFAVEKGgagGEANCSpSREVSQRGVHEIrEIRQFHFTGWPDHGVPYHATGLLGFVRQVKSksppSAGPLVVHCSAGAGR
 ...|       .. | |  .  .|.     | . .   ...  | ...  .|....| ||| |||      | ..  ..     |  |.||||||| ||
klelksg.....ivvenvsgskpmerd...aeiqit.llnltysgdqkm.svrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigr

TGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||  . |. .|. .||   .  . . |. || .|   .|.. ||.|||  .|. 
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1248-1492 3.8e-37 122.7 In-house 13-265 (270) alignment
Range on Protein: 1248-1492
Range on HMM: 13-265/270.0
SIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMD-SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPE
..    |... || .||||  .    | ... .  ..||||  .    ... ..| .. |||.|.|.|||.... . |..||. ..     . | .|||.
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

NGV----HRHGPIQVEFVSADLEEDIISRIFRIYNAArpqDGYRMVqQFQFLGWP-----MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEgRTVVHCLNG
.       ..| |.|  .|   ||  | .  |. . .   .  |.|  |..  ||        |. .| .. ||..|.| ....| . .|  ..||| .|
epkekvkledgkikvlalseekeegyiltrlrleekg...eerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaG

GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 ||.||. |. |....| ... ||| . .. ||......|.  .||.| |.. .|| .
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

0046846 (Phosphotyrosine protein) phosphatases II 1272-1492 5.9e-37 122.5 In-house 2-174 (176) alignment
Range on Protein: 1272-1492
Range on HMM: 2-174/176.0
PFLITIDGESSNYINAALMDSYKqpsaFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLC--PQYWPEngVHRHGPiqvefvsadleediisri
............|||| |.....    .|.||.|||.|. ||.........| ||.|..    . .  |.||||  ....|                   
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

friynaarpqdgyrmvqQFQFLGWPMYrDTPVSkRSFLKLIRQVDKWQEEYnggeGRTVVHCLNGGGRSGTFCAisivCEMLRHQRTVDVFHAVKTLRNN
                 |...|.|| . ..| . . .|.|.........|     |...|||  | ||.||..|    . .|.... ..|..|....|. 
.................qylhlpwpDh.gvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreq

KP-NMVDLLDQYKFCYEVALEYLN
.| ..|   .||.|.||..|..|.
RplgavqtpeQyrflyefellllk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1218-1492 8.4e-37 121.6 In-house 13-280 (439) alignment
Range on Protein: 1218-1492
Range on HMM: 13-280/439.0
KLDpQTNSSQIKEEFRTLNMVTPTLRVeDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRL
||| . .   .||.| ..| . |  .. ..|.|    .. |||  |. . |     |  | |   | ||||  .. | ..  .| || |  .|..|||||
kld.knkqeifkeifekinstspdyac.iaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrl

VLDYHCTSVVMLNDVDPAQLcpqYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKW
|.. ... .||| ..  .     ||| ..   .| | |         . . | |...|     .  | | ||... ||  .. |      |...| ..  
viekktvtivmltnlvesyk...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpd.knvpaqashvldflrainsa

QEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
... .   |  ||||  | ||.||  |. |  | |. .  ||.   || ||... .||. | || | |.  || . 
ndkee..ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1255-1490 1.1e-36 121.1 In-house 38-276 (287) alignment
Range on Protein: 1255-1490
Range on HMM: 38-276/287.0
NHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVML-NDVDPAQL-CPQYWPENGVH-RHGP
. .|||  |.|| |    .| .     |.||||  . ||..  |||..| |.. ||.||||.||. . .||...  .|. |.| | .||||. |  | | 
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

IQVEFVSAD-LEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRDTPVSkRSFLKLIRQVDKWQEEYN--GGEGRTVVHCLNGGGRSGTFCAISIVC
  |  .. | .| .   | .|. ..       |.|.|...| ||    .| .  ...... .| .  |      . |  |||.  | ||||.. |. .. 
ysvvlldydikePeygvralrlidlet..rearvvkqldllswPdkvlaPta.vglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
..|     |||  .|  ||. .  .|    |... ||    |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 949-1194 4e-36 119.4 In-house 48-341 (350) alignment
Range on Protein: 949-1194
Range on HMM: 48-341/350.0
RMKNRYGNIIAYDHSRVRLQ-------T-IEGDTNSDYINGNYIDGY-----HRPNH-YIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC
  |||| ||. |.||||.|.       .       .|||| ||.          |.. |||||.|...|. ||.... . .   |...|..|| .. || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPDDTEIYKDIKVTLIE--TELLAEYVIRTFAVEKGGAgGEANCSPSREVSQ--------RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVR----
.||.. .   . .|..     .    . ..... |.|  .  . | |   .. .          . .  .. |...  |.| .. ..   .|  .     
rYWqegsydditvklaskwenimgindsslysadvkkeas.dndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

---QVKSK---SPPSAGPLVVHCSAGAGRTGCFIVIDIMLD-------MAEREGVVD--------IYNCVRELRSRRVNMVQTEEQYVFIHDAIL
   .  ..       . |..|||||| |||| .. .| .|        . ..   .|        |   | |||..|..|||. .|..||..|.|
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_PTPN1_pd Subfamily PTPN1 1247-1489 4.1e-36 119.2 In-house 24-269 (290) alignment
Range on Protein: 1247-1489
Range on HMM: 24-269/290.0
CSIALLPRNHEKNRCMDILPPDRClpfLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN
.. | ||.|...||  |. | | .    |... .. .||||.|..  .    .|.|| ||||||. ||..| . .. .||||| |     . | ||||..
treaklpenrnlnryrdvspydhs...rikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

G-----VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdgYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKwQEEYNGGEGRTVVHCLNGGGRSG
      .  .  ..|...| . ..  . |.... |    .   | . .| .. || .   | |  .|||.. .| .     .   | .|.||  | ||||
eeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdf.gvpespaaflkflfkvre.sGslssdvGpavihcsaGiGrsG

TFCAISIV-CEMLRHQ--RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
||| .  .  .. ...   .||. . .  ||. .  ..   || .| |   ||
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

PTPc_DSPc_SM00012 1095-1195 4.3e-36 118.7 In-house 2-105 (105) alignment
Range on Protein: 1095-1195
Range on HMM: 2-105/105.0
IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSA--GPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHD
....|.||||||||| ... .| ..|.||..   |.  .|.|||||||.||||.|...||.|.. |.| . |||...|.|||..| .||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle

0043147 (Phosphotyrosine protein) phosphatases II 1280-1485 1.9e-35 117.5 In-house 3-155 (172) alignment
Range on Protein: 1280-1485
Range on HMM: 3-155/172.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVdpaqlcpqywpengvhrhgpiqvefvsadleediisrifriynAARPQ
|.|.|||| ..| |  |  ||.|| ||.||. ||||.. ....| .|.|..                                               |.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DGYRMVQQFQFLGWPMYRDTpvSKRSFLKLIRQVDKWQeeYNGGEGRTVVHCLNGGGRSGTFCAISIVCemlrhqRTVDVFHAVKTLRNNKPNMVDLLDQ
. .|.. |...|.|| .  .  . . .|......|...   .  .|...|||  | ||.||..|. ...      . .....||...|. .|..|   .|
llerlgiqylylpwpDhgvp..llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YKFCYE
|.|.|.
yrflyy

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 947-1196 6.5e-34 112.3 In-house 42-270 (288) alignment
Range on Protein: 947-1196
Range on HMM: 42-270/288.0
ENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKD
.|  ..|| |.   | .||.|.    |    ||. | .   . ... | .| |.. ||  .|.|. ...   |.|...|.| |. |  .|.|        
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

IKVTlietellaeyvirTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGC
|.                  | |  |. .   . |    .. ..|   ... |.  |.|.|||      | ..  .||       |.|||.|||.|||| 
igrl.............ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgt

FIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.|.| |.|...  .  . | . . .||  | . .||| ||...|  .|| 
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1091-1234 1.6e-32 107.4 In-house 87-231 (440) alignment
Range on Protein: 1091-1234
Range on HMM: 87-231/440.0
EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK-SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI
| | ..|.|. ||||.|||  |  .| ....|. |.   . |||.|||||||||||  |..| .|  |.|   .||.. .  .|. | .|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
|.|.||. ||||| .   ..     ...  .|.|. | ...||  
heavlegllcgdtliledditerveqiqwpnphtdksplqqefeg

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1225-1490 1.5e-30 101.1 In-house 5-258 (267) alignment
Range on Protein: 1225-1490
Range on HMM: 5-258/267.0
SSQIKEEFRTLNMVTPTLRVEDCSIALlpRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
  .|..||  .. ...|     .|||    |.|.||  | || |      . .  .  .||||. ...||.  |||||| || ||. ||. .. |.... 
eceiekefelikkisdtsstisqsiae..knqernrlddnlpyddtr...vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

VVMLNDVDPAQLcPQYWPEN--GVHRHGPIQVEFVSADLEEDIisRIFRIYNAARpQDGYRMVQQFQFLGWPMYRDtpvsKRSFLKLIRQ-VDKWQEEyN
.|.|  |   .. ...|| .    ...  . ||.     |.|   .|  .    . ..  . |  . .  | .  .    .. .|| .   . | | | |
ivlltkvftdni.rlfwPPkmgqakkyqdltvehslekeendy..qiitlelkfk.nesahnvtlyyykkwnintn....nkpylkplfgilaknqle.n

gGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 |.   ||.| .| ||||||  |    | .... ..|.|. .. .|. .. .|| ...| ...|.  ||
.gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0049260 (Phosphotyrosine protein) phosphatases II 1290-1485 1.7e-30 101.1 In-house 2-144 (152) alignment
Range on Protein: 1290-1485
Range on HMM: 2-144/152.0
MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWpengvhrhgpiqvefvsadleediisrifriynaarpqdgyrmvqq
.| |..| .|| ||.|.|||..||||.. ....| .|||.. ..     |.||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

fQFLGWPMYRDTPVSKRSFLKLIRQVDKWQeeYNGGEGRTVVHCLNGGGRSGTFCAISIVCemlrhqRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE
 |.| .|.  ... .   .|. . .....   .   .|...|||  | ||.||..|. ...      . |....||. .|. .|..|   .|..|.||
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 951-1196 6.8e-30 98.8 In-house 46-275 (312) alignment
Range on Protein: 951-1196
Range on HMM: 46-275/312.0
KNRYGNIIAYDHSRVrlqTIEGDTNSdYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiYkdikVT
 ||| ||  .|  |    |. || |  ||  |..    .|.....||||...|.  ||...    ..|||... .|| |  ||.||  |    .    | 
lnrypniqcwdrgrf...tlagdenf.yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.f....vd

LIETELLAEYvirTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGCFIVI
| .  . .||      .| ||   .        |  .   .   . .. .. |||||.|      | ..  ||        |.. ||||| |||| ...|
ledhrvytey...cteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlali

DIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
. |.         .. .    ||  |   |..  |||.   ..|| 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 946-1197 1.9e-29 97.5 In-house 33-270 (285) alignment
Range on Protein: 946-1197
Range on HMM: 33-270/285.0
DENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHR-PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEI
. |   ||| .. . . .|| |.    . . |||  ...    .  . ||.||||. ||. |||.|...|. | ..|.  |.| |  ||. |.|.   |.
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

YKDIKVTLIETELLAEYVIRTFAVEKGGAGGEancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKsKSPPSAGPLVVHCSAGAGR
 |  |  .  ||   | .  |          |               |   . . .   |||.  |  |  .. . . || |  |   |..|||||| ||
vkfgkyeitlteckeeaiagtilnaltvinte...........dasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvgr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
|  |. ||        .  ... . |||.|. |.. ||.  |..|..  ..|  
tatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

0051082 (Phosphotyrosine protein) phosphatases II 1281-1487 3.2e-28 93.6 In-house 2-149 (151) alignment
Range on Protein: 1281-1487
Range on HMM: 2-149/151.0
SSNYINAALMDSYkqpsaFIVTQHPLPntvkDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGvhrhgpiqvefvsadleediisrifriynaarpqd
 |.|||.  ....     ......||.    ||..|. .......|.|.. .. . ||.|.||.|                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

gyRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKwqeeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMlrhqrtVDVFHAVKTLRNNKPNMVDLLDQY
  . | ....|.|| . ..|.|  ..|........       ..| ..|||  | ||.||..|. .....      |... |.. .|   |..|   .|.
..ievlhipildwpdp.glplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

KFCYEVA
 |.. . 
lfqlfal

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1255-1489 1.2e-27 91.6 In-house 7-238 (239) alignment
Range on Protein: 1255-1489
Range on HMM: 7-238/239.0
NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENgVHRHG
|. |||  .|.  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||.. . .   .|||  .     . | ||||..   .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEM
 ..| .  ...  | | | | . .    |   | | |..|  ||  .  |    . | | |.. |   .   |    |.||  | ||.|.|  |  .   
nlrvtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpd.kgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
 ..|.|||.|  ||..|...| ||.  .|| | .   ||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1255-1488 1.5e-27 91.3 In-house 8-238 (239) alignment
Range on Protein: 1255-1488
Range on HMM: 8-238/239.0
NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENgVHRHG
|. |||  .|.  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||.. . .   .|||  .     . | ||||..   .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEM
 ..| .  ...  | | | | . .    |   | | |..|  ||  .  |    . | | |.. |   .   |    |.||  | ||.|.|  |  .   
nlrvtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpd.kgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL
 ..|.|||.|  ||..|...| ||.  .|| | .   |
akkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 978-1188 2e-27 90.8 In-house 77-272 (301) alignment
Range on Protein: 978-1188
Range on HMM: 77-272/301.0
YINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiyKDIKVTLIETELLAEYVIRTFAVEKGgaggean
 |  |.|.   .|...||||||...| .||| |. . .   |.|... ||    || .| | ...  .....   . ..  . .|    . |        
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknkelilnkkiskr.......

csPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSksppSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV
    . .   |  . | .  . .. |.|.|||   . |  ..  ||     |  |.||||||| ||. .||  ...    | .  ... . ...|| .| 
..tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrw

NMVQTEEQYVF
| |||..|  .
ngvqtnsqlyw

subfamily_ptpA1_pd Subfamily ptpA1 1226-1453 3.9e-27 90.0 In-house 21-258 (418) alignment
Range on Protein: 1226-1453
Range on HMM: 21-258/418.0
SQIKEEFRTLNM-VTPTlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSyKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
 .|||||| |.  | |.    . |     .|  |||  .||| ..    |  | | | |.||||  .|    |  ||.|| |||||. ||||.| . .| 
hkikeefrlleesvgps....etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcr

SVVMLNDV-D-PAQLCPQYWPE-----------NGVHRHGPIQVEFVS--ADLEEDIISRIFRIYNAARpqdgYRMVQQFQFLGWPMYrDTPVSKRSFLK
 .|||.   .     | .||||           ||    |   ||.|    | | .||.|  |.          | . |.|. ||| . . |   . | .
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege....trditqyqyegwpdh.nipdhtqpfrq

LIRQVDKWQEEYNGGEGRT---VVHCLNGGGRSGTFCAISIVCEMLRH
|.. . . |..      |    .|||  | ||.||||.  |. . | |
llhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1254-1489 9.8e-27 88.7 In-house 2-237 (237) alignment
Range on Protein: 1254-1489
Range on HMM: 2-237/237.0
RNHEKNRCMDILPPDRCLPfLITIDGESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPEN-GVHRH
.|. |||  .|   | .   ..   | .|.||||. ....   |  .| .| || .. .|||..| . .|. .|||  .     . | .|||.      .
enkiknrygnivaydhsrv.vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPIQVEFVSADLEEDIISRIFRIYNAARpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCE
| . | .   .   |   | . . .  . . . |...|.||  ||  |  |    ..|.. ... . . ..    |  ..||  | ||.| |  |  .  
gvltvslkkkeefsdytvrslllskrlt.lkevrlihqyqftswpd.rgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlr

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
  . .. ||..  |... ...| ...  ||| | ... ||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

PTPc_DSPc_SM00012 1385-1489 1.7e-26 87.8 In-house 2-105 (105) alignment
Range on Protein: 1385-1489
Range on HMM: 2-105/105.0
VQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ-RTVDVFHAVKTLRNNKPNMVDLLDQYKFC
|......|||    .| .  |.|.|.|.|.|.... .  .. .|||| .| ||.|||.|..|....|... ..||.|  || ||. .|.||. ..|| |.
vkhyhytgwpdh.gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YEVALE
|.. ||
yralle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1226-1491 5.7e-26 86.2 In-house 16-277 (307) alignment
Range on Protein: 1226-1491
Range on HMM: 16-277/307.0
SQIKEEFRTLNMVTPT-LRVEdcsiaLLPRNHEKNRCMDILPPDRClPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
.....||| |   ||  . ||      .  | .|||  |.   |..   ....|| .|.|| |  .    .|  ||..| || ||. .|| .... .  |
qalvdefrvlakktpegvtve.....afsantdknryqdvkcqdkg.rivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

VVMLNDV-DPAQL-CPQYWPEN-GVHR-HGPIQVEFVSADLEEDIISRIFRIYNAA----RPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkw
|.|| .| . |.. | |||| . | .  .|        |.|  . ..    . | .       .. | .|..|.  ||  | .|  . . . |.  |   
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd.rgvpqinltainlleav...

qeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
    .. .   ||||  | |||||  |||.|   |.. .   |. . |. ||....  .    || . . | |||.
....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1229-1490 2.1e-25 84.0 In-house 30-282 (290) alignment
Range on Protein: 1229-1490
Range on HMM: 30-282/290.0
KEEFrtLNMVTPTLRVEDCSIALLPRNH--EKNRCMDILPPDRCLpfLITIDGESSNYINAALMDSYKQPsaFIVTQHPLPNTVKDFWRLVLDYHCTSVV
  |.  |. . | | |.     .. .|   .|||  |.   |.    .|  ||   .|. |  ..  | .  ||.|| .| .|| |.||.||. . . .|
akey..leklkpylpvqylerkifdkntefkknrykdvvcndktr..vilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaiv

MLNDV--DPAQLCPQYWPENG--VHRHGPIQVEFV-SADLEEDIISRIFRIYNAARPQDgyRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeyn
|| ..  |    | ||.||.   |   | | |    . | ...|| ... . .    ..   ... ..   ||  .  . |. ..|...| . |      
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke..hklkhlkikswpd.ksvalstlallrtlrilrka.....

ggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
   |  ||||  | ||.||| || .  ..| . . .|.   |..||| . | |..  ||    |. |..
..sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_egg_pd Subfamily egg 938-1194 2.2e-25 84.0 In-house 30-267 (307) alignment
Range on Protein: 938-1194
Range on HMM: 30-267/307.0
APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVgrVKCCKYW
 .   | .|.|. | |   .   | |||.|.  .|    |.|  |...|    |..| .| |...|  ||||||. |.   |.|.|  .|    .|  ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PDDTE---IY--KDIKVTLIETELLAEYVIRTFAVEKggAGGEancspsrevsqrgvHEIREIRQFHfTGWPDHGVPYHATGLLGFVRQVkskSPpsagP
|   .   ..    .... .. .  |. . |   .     ||.              .| | .  .    .   .  |    .|  .|..   |     |
pkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd..............deerflehwq.gdvnnssdvysplrvlrklrnl...sk....p

LVVHCSAGAGRTGCFIVIDIMLDMAEREGVV--DIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
 ||..  |  ...... |.| |    |  ..   . ..|  || ||   |..  .|.|..  .|
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

0044763 (Phosphotyrosine protein) phosphatases II 1279-1492 4.4e-25 83.8 In-house 15-172 (178) alignment
Range on Protein: 1279-1492
Range on HMM: 15-172/178.0
GESSNYINAALMDSYkqpsaFIVTQHPLpntvKDFWRLVLDYHCTSVVMLNDVDP---AQlCPQYWPEN-Gvhrhgpiqvefvsadleediisrifriyn
 |.| ||||  .. .     ......|      |...|. ....|..|.|.. ..    . |..||||. |                             
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflk.cdpywpeeag.............................

aarpqdgyrmvqqFQFLGWPMYRDTPVS-KRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISIVCEMlrhqrTVDVFHAVKTLRNNKPnM
             .|.| .|.  ... .  . ||.... ......| .   |...|||  | |||||..|. .....      .....|.. .|. .| .
.............iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

VDLLDQYKFCYEVALEYLN
|   .|....||..|..|.
vpnpgqlrqLyefelrllk

0048076 (Phosphotyrosine protein) phosphatases II 1091-1194 5.2e-25 83.2 In-house 43-140 (145) alignment
Range on Protein: 1091-1194
Range on HMM: 43-140/145.0
EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDIMLDmaerEGvVDIYNCVRELRSRRVNMVQTEEQYVFIH
. |.. |.....|||||||  .  || |......  .   || .|||||| ||||.......||     .| |.........||.| ..|....|. |..
lerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrfly

DAIL
...|
efel

0048179 (Phosphotyrosine protein) phosphatases II 1090-1191 7.8e-25 82.7 In-house 44-139 (144) alignment
Range on Protein: 1090-1191
Range on HMM: 44-139/144.0
HEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDIMLdmaeREGvVDIYNCVRELRSRRVNMVQTEEQYVFI
...||. |.....||||||| ... || |.. ...  ... || .|||||| ||||.......|.    ..| ..........|||| ..|....|. |.
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

HD
..
le

subfamily_CG42327_pd Subfamily CG42327 949-1124 3.2e-24 80.2 In-house 29-192 (319) alignment
Range on Protein: 949-1124
Range on HMM: 29-192/319.0
RMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-----DDTE
. |.|. |..   ..|| || |  | .. |.. .|. ||.  ||.|||.| .....  ||||.||  ..  |. .|.| | |  .| .|.|     |.|.
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsreVSQrgvHEIREIRQFHFtGWPDHGVPYHATGLLGFVRQVKS
 | ||.||| . |   .|.| |. . .              | .   .| ||.  . .  |.. .|| . . |.  . .|.|
lyGdilvtlkgrevkdryaistlllkr..............vdk...eesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1242-1491 1.2e-23 78.5 In-house 20-295 (297) alignment
Range on Protein: 1242-1491
Range on HMM: 20-295/297.0
LRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGEsSNYINAALM--DSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLC
 | |. | |  .    |||  |||  |     |     | ..||||  .     ...  .|..| || .||.|||.|| .     .||.  .  |  . |
argesfssakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

PQYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRdTP-----VSK------------RSFLKLIR-------
  |||.   .  . | . |||.|   .|     .  .    |  .  |.|.  |||.|| .   |     . .              .| |.        
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemftamvf

-QVDKWQEEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 |..  . |.   .  ..|||  | ||||      .. ..||..|  ||   .. ||.... .|  |.|....|...|. |
lqleslraemp.rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 949-1197 1.7e-23 77.5 In-house 49-344 (349) alignment
Range on Protein: 949-1197
Range on HMM: 49-344/349.0
RMKNRYGNIIAYDHSRVRLQT--------------IEGDTNSDYINGNYID--GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK
  |||| .|. |.||||.|.                ..    |||| ||.    .   ..||||| |.  |. ||....  ..   .. ...  | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CCKYWPDDTeiYKDIKVTLIETELL----AEYVIRTFAVEKGGAG---GEANCSPSREVSQRGVH-EIR---EIRQFHFTGWPDHGVPYHATGLLGFVRq
| .|| . .  |..|.| | .. |        . | . |..        . ||   ..  .  .  . .   |. |. .  |.| .. .    .|  .  
cdiywqels..ysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqale.

VKSK-----------SPPSAGPLVVHCSAGAGRTGCFIVIDIMLD---MAEREGV--------V-DIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||..                 .|.|||||| |||| .. .|..|.   . ..| .           |.  | |||  |..|||   |...|..|.|. .
vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 991-1190 6e-22 72.8 In-house 5-197 (199) alignment
Range on Protein: 991-1190
Range on HMM: 5-197/199.0
NHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggEANCSPSrevsqr
 .||||| |..||. |||.|||   .  |.|| .      .    |||     |  |  . ||       ..|.| .. . .     .. . ||      
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.....nttapps......

gvheIREIRQFHFTGWPDHGVPYHATgLLGFV---RQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQ
     ||| .. || | ..  |  |  ..|||   |.|  |       |..|||| | | || |. .|| .   |  .  |||...  . ||  |. .. 
....treishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

TEEQYVFIH
. ..| ||.
slqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 992-1190 6.3e-22 72.7 In-house 5-196 (198) alignment
Range on Protein: 992-1190
Range on HMM: 5-196/198.0
HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggEANCSPSrevsqrg
.||||| |..||. |||.|||   .  |.|| .      .    |||     |  |  . ||       ..|.| .. . .     .. . ||       
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.....nttapps.......

vheIREIRQFHFTGWPDHGVPYHATgLLGFV---RQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQT
    ||| .. || | ..  |  |  ..|||   |.|  |       |..|||| | | || |. .|| .   |  .  |||...  . ||  |. .. .
...treishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

EEQYVFIH
 ..| ||.
lqhynfiy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1128-1195 3e-21 70.6 In-house 190-257 (267) alignment
Range on Protein: 1128-1195
Range on HMM: 190-257/267.0
PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
    ||||.||.| ||.| |.||| .|. | .|||.||.. .|..||.|. .|.| |.|..||. . |
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_eak_pd Subfamily eak 944-1196 1.1e-20 68.3 In-house 48-304 (332) alignment
Range on Protein: 944-1196
Range on HMM: 48-304/332.0
KKDENRMKNrYGNIIAYDHSRVRLQTIEGdTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-E
.. |.  .|   .|. ||.  ||| .     .  |||   ..  .  ..|| |  . .. .. ||.||  ... .|... . || .  |  ||.||.| |
arleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre

IYK--DIKVTLIETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTgWPDHGVPYHATG----LLGFVRQvKSKSPPSAGPLvVH
 .|   ..|.  |    . .  | . ..||    .         ..  .  ...   .. .   . ||.  ..     |  ....   ..|||  |. . 
elkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkv.mkevGvlllivmksallsstlkk.yihtppsfapi.iq

CSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.. |. |.| |.|||... . .  .. .  . . .   .|.|.  | .. |. ||....|. 
sarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1249-1479 3.7e-20 66.9 In-house 46-269 (301) alignment
Range on Protein: 1249-1479
Range on HMM: 46-269/301.0
IALLPRnhEKNRCMDIlPPDRCLPFLITIDGESsNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGV
 | ||.  .|.|   . | .      .  ||.    | |  ...  .|  ||.|| ||.|| .||| ..  |.   .|||     .  . | .| | .  
yaylpk..dkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

HR--HGP--IQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFC
..   |   |...     |...|. | ... ....  .  | |  .|.  |.  |..| |.    .|.  | |        |   |||| .| ||| .| 
ekldigrfkikiknkelilnkkiskrtlevedstgkfa.trtvthyqysewtd.rgvPkshaelfdlmelvkk.......sekPivvhcsaGiGrsvafi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQ
.  ..   .  ..|... .|.| ||... | |    |
gteylareveadptieltealkhlrehrwngvqtnsq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1382-1492 9.2e-20 65.4 In-house 277-386 (392) alignment
Range on Protein: 1382-1492
Range on HMM: 277-386/392.0
YRMVQQFQFLGWPMY-RDTPVSKRSFLKLIRQVDKWQEeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQY
   | |.|| ||| .  |     ||.||||| |    .  .  |   .|||| | ||.| ||.       . .  .||.| .|| || .. ..|.  ..|
shtvtqyqfhgwpkhgsdqqsgarsllkliravkgstn..skkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeey

KFCYEVALEYLN
 | |.|  ||| 
afvydvireylh

subfamily_egg_pd Subfamily egg 1283-1488 8.5e-19 62.3 In-house 69-267 (307) alignment
Range on Protein: 1283-1488
Range on HMM: 69-267/307.0
NYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPE--NGVHRH--GPIQVEFVSADLEEDIISRIFRIYNaARP
..| |  ..       ||..| || |||.||||.|   ..  .|||.    .. |. |||   .   .   | ...| .  | . | . |. ..     .
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGg

QDGYRMVQQFQFlGWPMYRDTpVSKRSFLKLIRQVDKwqeeynggegRTVVHCLNGGGRSGTFCAISI-VCEMLRHQRT-VDVFHAVKTLRNNKPNMVDL
.|  | .. .|   .    |   |    |...|.. |           .||.. .|  ...|. || | ....||   |   | .||. || ...  |. 
ddeerflehwqg.dvnnssdv.ysplrvlrklrnlsk..........pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

LDQYKFCYEVAL
  .| | | . |
vllylfvyrlvl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1133-1197 9.6e-19 61.6 In-house 1-65 (69) alignment
Range on Protein: 1133-1197
Range on HMM: 1-65/69.0
LVVHCSAGAGRTGCFIVIdiMLDMA--EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
.|||||.|.|||| || |  |..||    | .|||.| |. .|  |  ||  | .|.|||||. || 
mvvhcssgtgrtgtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 946-1051 1.2e-18 62.0 In-house 31-132 (267) alignment
Range on Protein: 946-1051
Range on HMM: 31-132/267.0
DENRMKNRYGNIIAYDHSRVRLQTIEGDtnsdYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMvWHENTASIIMVTNLVEVGRVKccKYWPDD---TE
 .|. .||. . . ||..|| |.| | .    |||  |..||.. |..|.||.|.. || ||. . .|..  ..|..   | .. ..  ..||     ..
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltv.ihdqkvpvivlltkvftdnir..lfwPPkmgqak

IYKDIKVTL
 |.|. |  
kyqdltveh

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1228-1490 2.6e-18 60.7 In-house 13-268 (281) alignment
Range on Protein: 1228-1490
Range on HMM: 13-268/281.0
IKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLI--TIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
.|.||  |    |.   . |..   | | .||| ..|   |     |     . .|..|| |  . |      .|.|| |  .|  ||||.. .   |..
fkqefsnlpgdpps...dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMLNDVDP--AQLCPQYWPENGvhrHGPIQVEFVSADLEEDIISRIFRIYNAARPQDG-YRMVQQFQFLGWPMYRdTPVSKRSFLKLIRQVDKWqeeyng
||| ..     . | .|.| |    |  .|.. .| . |.  . . .         .|  |.. .. .  || ..  | |   .||..|..         
vmlcqfletnrekcaeyfprna...hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwq.vpessevmlkilrkirar......

gEGRTVVHCLNGGGRSGTFCAISIVCEMLR-HQRTVDVFHAVKTLRN-NKPNMVDLLDQYKFCYEVALEY
     |.||  | |||||. |. |  . .. |    |. . |  ||   .   |. |.|| . ..| |..
.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1240-1357 3.5e-18 60.2 In-house 30-158 (392) alignment
Range on Protein: 1240-1357
Range on HMM: 30-158/392.0
PTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND------VD
|   . . ..|  . | .|||  .||| |.    |  | |   |.|.||. ..|...  |.| .| | . ...||||.|.. . |...|...       |
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

PAQLCPQY----WPENGVHRHGPIQVEFV
 |. . |.    ||...| .|    ..|.
dartvaqfhftewPdkdvpkhtssllkfi

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 997-1190 4.4e-18 59.7 In-house 97-281 (302) alignment
Range on Protein: 997-1190
Range on HMM: 97-281/302.0
QGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEyVIRTFAVEKGGAGGEANCSPSREVSqrgvHEIREIR
  | ..|.  .| .. . |.| .. ....|| .  || .|. |. .     .   ..|  . .  .  |.  |.      .   ..  .    .  . . 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvkt.dleeftdkksfklytveiknekkkk....kvkktvd

QFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
 ..|..||||| | .|   |  ..  .|        ..|||||| |||| .. |   ...  .. | |. . |  .|. |   ||.|.| ... 
ilafsawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1134-1198 4.5e-18 59.4 In-house 1-65 (69) alignment
Range on Protein: 1134-1198
Range on HMM: 1-65/69.0
VVHCSAGAGRTGCFIVIdiMLDMA--EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||||.|.|||| || |  |..||    | .|||.| |. .|  |  ||  |..|.|||||. ||  
vvhcssGtGrtGtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk

0048076 (Phosphotyrosine protein) phosphatases II 1371-1490 9.6e-18 59.7 In-house 35-142 (145) alignment
Range on Protein: 1371-1490
Range on HMM: 35-142/145.0
RIynAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEynggEGRTVVHCLNGGGRSGTFCAISIVCEmlrhQRtVDVFHAVKTLRNNK
..  .  ... .|.. |...|.|| . ..| . . .|...........|    .|...|||  | ||.||..|. .. .    .. |....|.. .|.  
nl..tselellerlgiqylylpwpDh.gvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqr

PNMVDLLDQYKFCYEVALEY
|..|   .|..|.||. ||.
pgavpnpgqlrflyefelel

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1297-1486 1.1e-17 58.8 In-house 5-199 (199) alignment
Range on Protein: 1297-1486
Range on HMM: 5-199/199.0
SAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLG
  .|.||||| .|. |||..| .     .||.|| .  .    | |||  |.|. ..| . |   .   . |     . . | .      | . ..||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPMyRDTP-VSK-RSFLKLIRQVDKWQEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT--VDVFHAVKTLRNNKPNMVDLLDQYKFCYEV
|   . || |.    |.   |.| |  |. .  .   .||| .| | .| | |. |        .|  ||.|   | ||. .  ..  |..|.| |.|
wke.kttpnvalfvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1298-1486 1.3e-17 58.6 In-house 5-198 (198) alignment
Range on Protein: 1298-1486
Range on HMM: 5-198/198.0
AFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGW
 .|.||||| .|. |||..| .     .||.|| .  .    | |||  |.|. ..| . |   .   . |     . . | .      | . ..||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PMyRDTP-VSK-RSFLKLIRQVDKWQEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT--VDVFHAVKTLRNNKPNMVDLLDQYKFCYEV
   . || |.    |.   |.| |  |. .  .   .||| .| | .| | |. |        .|  ||.|   | ||. .  ..  |..|.| |.|
ke.kttpnvalfvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1227-1491 1.4e-17 58.3 In-house 25-289 (305) alignment
Range on Protein: 1227-1491
Range on HMM: 25-289/305.0
QIKEEFRTLNMVT-PTLRVEDCSIALLP-RNHEKNRCMDILPPDRCLPFLitIDGESSNYINAALMDSYKQPS-AFIVTQHPLPNTVKDFWRLVLDYHCT
...|||| |   | | .          .  .  |||  |.   |. .  |   .   |.|| |  .     |   ||..| || .|. .|| .|.. .  
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

SVVMLN-DVDPAQL-CPQYWPENG---VHRHGPIQVEFVSAD--LEEDIISRIfRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkw
 .|||   |.  .| | ||||      .. .. | || ||    .| |   .|  . | .   |    |...|.  ||  |  |  | . |.|.  .   
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi.tllnltysgdqkmsvrhlqwtewpd.rgvppckltslellsai...

qeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTV-DVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
     | .   ||||  | ||.||  ||  . | .  .. .  . . ||.||...   ..   || | . | |.|.
....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 995-1195 4.1e-17 57.1 In-house 39-219 (255) alignment
Range on Protein: 995-1195
Range on HMM: 39-219/255.0
AtqgpmqeTIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLieTELLAEYVIRTFAVEkggaggeancspsREVSQrgVHE
        |.  |....   .|  ..|.... | |..|| .|.|   |.  ...|..||   |.  |. |.||  .               ....    .
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtt..tkssadvvlrtleit.............stlge..kkk

IREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSkSppsaGPLVVHCSAGAGRTGCFIVIDIMLD-----MAERE-GVVDIYNCVRELRSRRVNMVQTEEQ
 .... ....||...  |  |  .|  .. |.  |     ..|||||.| ||.  |......       . . | . .|  . ..||||.|   ..|  |
thtvkhysykGWieknaPelareilnilkvvrd.s....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

YVFIHDAILE
  |    .|.
lafsilmvld

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1274-1491 9.9e-17 55.9 In-house 59-271 (288) alignment
Range on Protein: 1274-1491
Range on HMM: 59-271/288.0
LITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRhGPIQVEFVSADLEEDIISRIFR
 . .. ..  ||.| .. | | .  .| .| ||  |.. .|...|.     .|||...     .   .|.| .  ..   |.        . . | .. .
rvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek.arigrlctvvkkkradidklvk

I--YNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkwqeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN
.   .  .. .   .|..  .| |.     | .  |.|.|.  .       .  .   |||. .| ||.||.  | |. |.|| .  . . . .. ||..
vsllriskegeekvivkilhlleWdd.dgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklree

KPNMVDLLDQYKFCYEVALEYL
. . .    || . . . ||.|
rfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1275-1491 3.9e-16 53.8 In-house 52-270 (285) alignment
Range on Protein: 1275-1491
Range on HMM: 52-270/285.0
ITIDGESSNYINAALMDS-YKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPEN--GVHRHGPIQVEFVSADlEEDIISRI
. .     .|| |. |    |. |..| || |||.|. |||... . . . |.||  .     . |  |.||.   | . |  .. .  .  || |   |
vvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteck.eeaiagti

FRIYNAARPQDGYRMVQQFQFLGWPMYRD--TPVSKRSFLKLIrqvdKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLR
.        .|       ....  | . |  .|   | ...|     || .. |  |   .|||  | ||. ||  |      .  .  ....  |. .|
lnaltvintedasseplymnhvqvpwwpdqlapedarpmiely....kwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremr

NNKPNMVDLLDQYKFCYEVALEYL
  . . |.   |. | | | .||.
amrfqavqshmqflflyvvlmeyf

0048179 (Phosphotyrosine protein) phosphatases II 1369-1485 4.6e-16 54.3 In-house 30-139 (144) alignment
Range on Protein: 1369-1485
Range on HMM: 30-139/144.0
IFRIYNAARPQDGYRM---VQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEeyngGEGRTVVHCLNGGGRSGTFCAISIVCemlrHQRtVDVFHAVKT
|  ..| . . . . .   . |...|.||  ...| .   .|.... .....|     .|...|||  | ||.||..|. ..     ... .....|.. 
ittvinlteeyepefleregiqylhlpwp.Dhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealal

LRNNKPNMVDLLDQYKFCYE
.|.  |..|   .|..|..|
vrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1254-1493 1.4e-15 51.8 In-house 42-278 (312) alignment
Range on Protein: 1254-1493
Range on HMM: 42-278/312.0
RNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN-------
. .. ||  .|   ||     .|. |.   || | ..    .|  |..|| || ||.  ||.|.|   .||...|  .  | .. | .|  .        
kfkdlnrypniqcwdrgr...ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--GVHRHGPIQVEfVSADLEEDIISRIFRIYNAARPQDGyrMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEeynggegRTVVHCLNGGGRSGTFC
   |.     ..| .     . |  |....   |  |.    ....|.  || .   | |  . |.|.  | | .          . ||  | ||.||..
dhrvyteycteie.iggkskdkithrvlkvvvkatgqes..klnhyqwaswpdh.gmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtla

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 |  .   ||| |  .| ..   ||...   |  . || ..  . ||.| |
liesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1383-1492 2.6e-15 50.7 In-house 89-195 (440) alignment
Range on Protein: 1383-1492
Range on HMM: 89-195/440.0
RMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
| ..|... |||  .  |      ||.|..|.. ||.   |.|  .|||  | ||.|   |.  .    ..   .|.|  ....|||.|.||.  .|| |
rtlkqyhyqgwpd.kgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYEVALEYLN
 .|. || | 
vheavlegll

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 905-998 3.7e-15 49.9 In-house 5-95 (95) alignment
Range on Protein: 905-998
Range on HMM: 5-95/95.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTiegDTNSDYINGNYIDGYHRPNHYIATQG
| |. .  |. .|.      | .|. |      ||.     . |  |||. ||. || .|| | |     .|||||  ..||| | | |||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_CG42327_pd Subfamily CG42327 1127-1192 1e-14 48.9 In-house 244-310 (319) alignment
Range on Protein: 1127-1192
Range on HMM: 244-310/319.0
PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHDA
  | |||||||| |.||||  |  || .   |     ||| . |  .|  | . |.| ||| ||.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1254-1470 1e-14 48.8 In-house 51-269 (310) alignment
Range on Protein: 1254-1470
Range on HMM: 51-269/310.0
RNHEKNRCMDILPPDRCLPFLiTID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVH-RH
..  |||  |..  | .   | .||     .|| |  . .    |.||..| ||  |. ||||....  . |...|  |       |  |||  ||   .
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GPIQVEFVSADLEEDIISRIF-RIYNAARPQDGYR---MVQQFQFLGWPMYRDTPVSKRSFLKlIRQVDKWQEEynggEGRTVVHCLNGGGRSGTFCAIS
| |.|  .|   ||  |  .   .     | |         . ... || . |. |        . |    |       |  ||||  | .| .. .|. 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht.vpqrllaqvr....hgpcvvhcsagkdrlyvvvalk

IVCEMLRHQRTVDVFHAVKTLRNNK
.  . |..   ||. . .  |....
lkidkldrglkvdaeevktellksr

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 947-1198 1.6e-14 48.2 In-house 46-280 (303) alignment
Range on Protein: 947-1198
Range on HMM: 46-280/303.0
ENRMKNRYGNIIAYDHSRVRLqtiegdTNSDYINGNYIDgYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKD
.|  |||. ..|  |||.|.|      ..| ||  .|..  .  .. | || |.. |  |||.|. ...   ....    |  ..     .| . .. | 
knmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

IKVTlIEtelLAEYviRTFAVEKGGAGGeancspSREVSQRGVHEIreIRQFHFTGWPDHGVPYH-ATGLLGFVRQVKS---KSPPsAGPLVVHCSAGAG
 . . |    . |.  .   . .| .           ||.   . .  .   |.  ||   .| . .  ..  . |..|   |  . . | |    .| |
eers.ir...vgef..krvelgdgwvlk......vlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd.stptvymslsgcg

RTGCFIVIDI-MLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|.| | ...   | . . .  .|. .|.  .|  |.  ||   |. ...  . |  |
ragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1254-1490 1.4e-13 45.1 In-house 46-278 (303) alignment
Range on Protein: 1254-1490
Range on HMM: 46-278/303.0
RNHEKNRCMDILPPDRClpfliTIDGESSNYINAALMDSYKQPSAfIVTQHPLPNTVKDFWRLVLDYHCTSVV-MLNDVDPAQLCPQY-WPENGVH---R
.| .||| .|..  |        .    | || |. ..   .  | |.|| ||. |  |||..... .   |. .| | .  .|  .. .|.|       
knmdknrfvdvicldhs.....kvklsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

HGPIQV-EFVSADLEEDIISRIFRIYNAArpqdGYRMVQQFQFLGWPMYrDTPVS-KRSFLKLIRQVDKWQEEYNGGEgRTVVHCLNGGGRSGTFCAISI
.  |.| ||   .| .    ..  . |         ...  ..  ||   . |      |.| | |..     |  ..  ||   | | ||.|||. .  
ersirvgefkrvelgdgwvlkvlsvsngd....yksflhvhhykawphn.sipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfet

VCE-MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
    .   | ..|. . ....|| .   |. | |. . | .  |.
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1291-1353 1.9e-13 44.6 In-house 230-292 (440) alignment
Range on Protein: 1291-1353
Range on HMM: 230-292/440.0
DSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDpAQLCPQYWPENGVH-RHGPIQ
. | .  ||| || ||  || |||||| ||. ....|||...  . |  ||| |      ||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln.dktcsiywpvntrsvtfgpft

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 905-986 4e-13 43.5 In-house 6-85 (440) alignment
Range on Protein: 905-986
Range on HMM: 6-85/440.0
IRVADLLQHITQMKCAEgyGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDG
| |||. ... . . .    |..|.  .  | | | | |   .|..|||| ||.||||||| |. ..|  .|||||  ||.|
iivadfadyvqnnrrsr..afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

subfamily_hpo-7_pd Subfamily hpo-7 1000-1192 5.1e-13 43.5 In-house 43-222 (263) alignment
Range on Protein: 1000-1192
Range on HMM: 43-222/263.0
MQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLieTELLAEYVIRTFAVEKggaggeancspsrEVSQrgVHEIREIR
. .||  |....   .|  ..|...  | |..|| .|.|   |.  ......|.   |.   . ...|  . .              ...    ......
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlells.............tlge..Kkkthtvk

QFHFTGWPDHGVPYHATGLLGFVRQVKSkSppsaGPLVVHCSAGAGRTGCFIVIDIMLD-----MAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIH
.. ..||...  |  |   |  .. ..  |     .||||||.| ||.  | |....       . . . . .|  . ..||||.|   ..|  |  |  
hysykgWiekndpelareilnilkvarn.s....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

DA
  
lm

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1280-1491 6.9e-13 43.0 In-house 71-287 (305) alignment
Range on Protein: 1280-1491
Range on HMM: 71-287/305.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGV-----H-RHGPIQVEFVSA---DLEEDIISR
   .|| |  . .  .|  || || || .|  ||| . |. .  .. || ..    |. | .|.. .       . .   |.| | |.   ....|  ..
wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

IFRIY-NAARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTV-DVFHAVKTL
. .       |    | |... .  ||  |  | .  . |.|. .            | .||||  | ||.|.   .  ... |   . . |  . .. .
vtetvlviegpgekarkvthyhwidwp.drgvpaadlailellekarp.......skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqki

RNNKPNMVDLLDQYKFCYEVALEYL
|... | ..  .|| | ..| |.|.
reqrnnsiqtdaqylfvhqvilnyf

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 943-1054 8.6e-13 42.5 In-house 91-198 (244) alignment
Range on Protein: 943-1054
Range on HMM: 91-198/244.0
AKKDENRMKNRYGNIIAYDHSRVRLQtiEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWhENTASIIMVTNLVEvgrvKCCKYWPDDT-
| . .|  ||| |  . .| .|| |   .|     |||  ..    |   || || |. .|  |||.|.  |    ...|   ||    .  .||||   
afnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsve....eedeywpdsep

-EIY-KDIKVTLIET
 | | .|| ||| . 
lewyeeditvtltdr

fn3 Fibronectin type III domain 498-574 1.4e-11 37.6 Pfam-A 15-84 (85) alignment
Range on Protein: 498-574
Range on HMM: 15-84/85.0
KIFLQWREPTQTYGVITLYEITYKAVSSFDpeidlsnQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP
.. |.| .|..  | || ||..|. ... .       .. ...  ...|.. . || |||.|.|...| ...| ||.
sltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_CG42327_pd Subfamily CG42327 1424-1490 1.6e-11 38.5 In-house 247-314 (319) alignment
Range on Protein: 1424-1490
Range on HMM: 247-314/319.0
EGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ-RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 |  |||| .| ||.|.  |  |  . | .  |.||. . |  .|... . |   .||.| | |. ||
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 947-1029 2e-11 38.0 In-house 33-114 (332) alignment
Range on Protein: 947-1029
Range on HMM: 33-114/332.0
ENRMKNRYGNIIAYDHSRVRLQTIEGdtNSDYINGNYIDGYHRPNHYIATQGPMQE-TIYDFWRMVWHENtASIIMVT-NLVEVG
.|   ||   . ..||||| |   .|  . |. | ...||| . . || .| |... | | |||||   .  |.|.|  .. |  
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserk.psmilvfgdidekq

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1099-1194 2.9e-11 37.3 In-house 187-282 (302) alignment
Range on Protein: 1099-1194
Range on HMM: 187-282/302.0
HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
..| |... || . . |   . .|  |. ..  ..|.    |||| | |..  . ..  ...  . | . |. .|| | ..|.. .|||... |.|
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1282-1484 5.7e-11 37.1 In-house 46-252 (290) alignment
Range on Protein: 1282-1484
Range on HMM: 46-252/290.0
SNYINAALMdSYKQPSAFIVTQHPLPN-------TVKDFWRLVLDYHCTSVVMLNDVDPAQ------LCPQYWPENG--VHRHGPIQVEFVSADLEEDII
..|| |  . .. .  ..|.|| |. .       |...|| .. . . ..|||| ...  .       | .| ||.     . . ..|.  |   |.|..
ddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

SRIFRIYNAARPQdgyRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeynggEGRTVVHCLNGGGRSGTFCAISIVCEMLR-HQRTVDVFHAVKT
 |   .    . .     |.  .. || . . .. .....|.||..| .        .   .||| .|  || .. || . . ..   .  | .  ..|.
tRelvvkfddeee...ftvtHsllkgWnk.lnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

LRNNKPNMVDLLDQYKFCY
||... ...    .. |  
lrkqralaitsalelafvd

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 947-1111 6e-11 35.5 In-house 26-157 (169) alignment
Range on Protein: 947-1111
Range on HMM: 26-157/169.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGnyidgyhrpnhyiatqgpmqetiydfwRMVWHENtASIIMVTNLVEvgrvKCCKYWPDDTEIYKD
 |  |||    .|  | ||.|| .  |  |||||                            ||.|  | ||.|.|    .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetn.asvivvlgdtd....dknnfwpekedyqlh

IKVTLIETELLAEYvIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYH
  | | |    . | .||  |..  .| |.    |  . .   .   ... .|.. ||. |||  
pavilgewytdsly.vrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1250-1344 6.1e-11 36.4 In-house 91-181 (244) alignment
Range on Protein: 1250-1344
Range on HMM: 91-181/244.0
ALLPRNHEKNRCMDILPPDRCLPFlITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQlcpQYWPEN
|. | |  |||    || |      ..    .  ||||...    . . .|.||||| .|  |||...|. |   .|.|  |.  .   .|||. 
afnpnnswknregaglpfdfnrvp.lskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...eywpds

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1406-1491 1.1e-10 35.5 In-house 200-285 (302) alignment
Range on Protein: 1406-1491
Range on HMM: 200-285/302.0
FLKLIRQVDKW-QEEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
. .||... |  ... . .. .||.   || || |.| .  .. | | ..  . .   ||..|...|..|| |.|| . | ..| |.
yaeliktaakvfakkik.adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 947-1111 2.2e-10 33.6 In-house 25-156 (169) alignment
Range on Protein: 947-1111
Range on HMM: 25-156/169.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGnyidgyhrpnhyiatqgpmqetiydfwRMVWHENtASIIMVTNLVEvgrvKCCKYWPDDTEIYKD
 |  |||    .|  | ||.|| .  |  |||||                            ||.|  | ||.|.|    .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetn.asvivvlGdtd....dknnfwpekedyqlh

IKVTLIETELLAEYvIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYH
  | | |    . | .||  |.   .| |.    |  . .   .  .... .|.. ||. |||  
pavilGewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1256-1457 3.5e-10 34.4 In-house 30-185 (255) alignment
Range on Protein: 1256-1457
Range on HMM: 30-185/255.0
HEKNRCMDILppdrclpflitidgessnyinaalmdsykqpsafivtqhplpnTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ
 .|.. ...|                                           ||. |.. .     . |||| |      . | .|.| .   .    .
dkkrknlysl...........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad

VEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEeynggegrTVVHCLNGGGRSGTFCAISIVCE-MLR
|. ....   |.. |  .|      .   . |. ... ||.  . .|   |  |.... | . .          |||| .|.||| .|  . .|   |.|
vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWie.knaPelareilnilkvvrdsks........vvvhCstGiGrsaafvlaelvyqkmir

HQRT---V
  .|   |
sldttetv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1428-1492 3.8e-10 34.0 In-house 1-65 (69) alignment
Range on Protein: 1428-1492
Range on HMM: 1-65/69.0
VVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
||||  | ||.||| || .    .. .. ||.|  |. .|  .| ||   ..| | ..   | | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk

subfamily_hpo-7_pd Subfamily hpo-7 1301-1456 6.1e-10 33.4 In-house 42-187 (263) alignment
Range on Protein: 1301-1456
Range on HMM: 42-187/263.0
VtqhpLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRD
.    | .|.. |.. .     . |||| |   .  . | .|.| .   .    .|. ....  .|.. .   . .    .   . |..... ||.  .|
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

tPVSKRSFLKLIRQVDKWQEeynggegrTVVHCLNGGGRSGTFCAISIVCE-MLRHQRT
 |   |. |.... . . ..         |||| .|.|||  |  . .|   |.|  .|
.pelareilnilkvarnsks........lvvhcstGiGrsaafsvaElvyqkmirsldt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 984-1041 8.1e-10 32.6 In-house 229-283 (440) alignment
Range on Protein: 984-1041
Range on HMM: 229-283/440.0
IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEvgrVKCCKYWPDDT
..|| . | .|||| |.. |. ||||.|   . ..|||. .| .     |  ||| .|
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1428-1491 9e-10 32.8 In-house 2-65 (69) alignment
Range on Protein: 1428-1491
Range on HMM: 2-65/69.0
VVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
||||  | ||.||| || .    .. .. ||.|  |. .|  .| ||    .| | ..   | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1280-1349 1.3e-09 32.2 In-house 81-158 (350) alignment
Range on Protein: 1280-1349
Range on HMM: 81-158/350.0
ESSNYINAALMDSY----KQPSAF--IVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVHRH
....||||  .       .. . |  | || |||.||.||....|  . . ...|.. .    . | .||.| ... .
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsyddi

subfamily_CG42327_pd Subfamily CG42327 1226-1355 2.2e-09 31.4 In-house 5-136 (319) alignment
Range on Protein: 1226-1355
Range on HMM: 5-136/319.0
SQIKEEFRTLNMVTPTLRvedcsiALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQ-PSAFIVTQHPLPNTVKDFWRLVLDYHCT
... |||| |  .           .. .  ..|.| ....|     . |  | | ....|..|. .  |.. |. .| .| .| ..  ||||.| .    
edvaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsr

SVVMLNDVDPAQ--LCPQYWPEN----GVHRHGPIQVE
 .| | |.       |..|.| .    . . .| |.| 
vivqltdlselGikvcaeylPtketldntslyGdilvt

fn3 Fibronectin type III domain 287-361 4.4e-09 29.5 Pfam-A 5-80 (85) alignment
Range on Protein: 287-361
Range on HMM: 5-80/85.0
PPQLASVGATYLWIQLNANSiNGDGPIVAREVEYCTASGS--WNDRQPVDST-SYKIGHLDPDTEYEISVLlTRPGEG
 ... .|..|.| .. .. . .|.|||.  ||||....|.  |. ..   .| |... .| |.||||..|  .. |.|
nlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq.avngag

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1099-1204 1.1e-08 29.6 In-house 164-257 (290) alignment
Range on Protein: 1099-1204
Range on HMM: 164-257/290.0
HFTGWPDHGVPYHATGLLGFVRQVKSKsppsAGPLVVHCSAGAGRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILeac
 . || .  |. .   ||  ...|| .      | .|||  |  |  ..  |..   .  | .| | . . . .||..| ......... |.  .|.   
llkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...

lcgdtsV
      .
......l

subfamily_eak_pd Subfamily eak 1257-1401 1.1e-08 28.9 In-house 54-196 (332) alignment
Range on Protein: 1257-1401
Range on HMM: 54-196/332.0
EKNrCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLN-DVDP-AQLCPQYWPENG--VHRHGPI
..|  ..|.| || |  | .   .   ||||.|..  .    .|.|  .  . |  ||..||. .  ..|.|  ||.   .   .|.|...  . ..| .
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

QVEFVSAdLEEDIISriFRIYNAARPQDGYRmVQQFQFLGWPMYrDTPV
.||  .  ....|.   .| .   .  . .| |. ... ||  . ..|.
dverkef.vkrnile..trllelskGnethr.vlhykvfGwtet.tlpk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1280-1328 2.3e-08 27.9 In-house 68-116 (347) alignment
Range on Protein: 1280-1328
Range on HMM: 68-116/347.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVML
.. .||||. .   .    .|.||.|||.||.|||..|   . | || .
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_PTPDC1_pd Subfamily PTPDC1 1098-1191 3e-08 28.3 In-house 85-170 (182) alignment
Range on Protein: 1098-1191
Range on HMM: 85-170/182.0
FHFTGWPDHGVPYhATGLLGFVRQVKSKSppSAGPLVVHCSAGAGRTGCFIVIDIMLdmAERegvVDIYNCVRELRSRRVNMVQTEEQYVFIHD
..  ||.|.||.   . .|  |. |..    . | . ||| || ||||  |   ..   |.|   ..  . .. .||.| . .|| ||  ....
vynfgwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylvy..akr...ltaekaiklvrskrpksiqtreqvelvke

0038934 (Phosphotyrosine protein) phosphatases II 1388-1483 3.7e-08 28.8 In-house 80-169 (194) alignment
Range on Protein: 1388-1483
Range on HMM: 80-169/194.0
FQFLGWPMYRD-TPVSKRSFLKLIRQVDKWQEEYNGGegRTVVHCLNGGGRSGTFCAISIVCemlrhQRTVDVFHAVKTLRNNKPNMVDLLDQYKFC
...| .|.  | |. |    |. .. ||.. .| .||    .|||  | ||.||..|  ...      .  ..  |....|  .|...   |...  
ieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleal

ig Immunoglobulin domain 199-261 3.8e-08 24.6 Pfam-A 1-63 (64) alignment
Range on Protein: 199-261
Range on HMM: 1-63/64.0
GQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCM
|. .|..||. ....  |  | .. ...  . |   |. . . . .... |.|| |.| |.|.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1282-1348 1.2e-07 26.1 In-house 13-76 (130) alignment
Range on Protein: 1282-1348
Range on HMM: 13-76/130.0
SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQlcpQYWPENGVHR
 .|||| ..    . . .. ||||| .|  |||...|. .   .|.|  |.  .   .|||.     
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed...eywpdsePle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1279-1344 1.3e-07 25.3 In-house 87-156 (349) alignment
Range on Protein: 1279-1344
Range on HMM: 87-156/349.0
GESSNYINAALMD--SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPEN
|   .||||  .    ..    .| || ||| ||.||....|      |. ||| .  .|  | .|| | 
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 946-1022 3.2e-07 24.2 In-house 35-116 (347) alignment
Range on Protein: 946-1022
Range on HMM: 35-116/347.0
DENRMKNRYGNIIAYDHSRVRLQT-----IEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV
. .  |||  .    | .|| |        . |    |||  .|      ..|| || |. .|. |||.||   . . .. .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 959-1053 4e-07 24.4 In-house 4-88 (130) alignment
Range on Protein: 959-1053
Range on HMM: 4-88/130.0
AYDHSRVRlqtiegdtNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWhENTASIIMVTNLVEvgrvKCCKYWPDDTEIY---KDIKVTLIE
 .. ||..        . .||| ...    | . |. || |. .|  |||.|.  |    ...|   ||    .  .||||   .    .|| ||| .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsve....eedeywpdsePlewyeediivtltd

0038934 (Phosphotyrosine protein) phosphatases II 1101-1187 5e-07 25.1 In-house 85-170 (194) alignment
Range on Protein: 1101-1187
Range on HMM: 85-170/194.0
TGWPDHGVPYHATGLLGFVRQVKSKSPPS-AGPLVVHCSAGAGRTGCFIVIDIMLDmaEREGVVDIYNCVRELRSRRVNMVQTEEQYV
  .||.|..     || |.. |. .   .  |  .||| || ||||....  ..     .  . . .. .|| |   .. ..  |...
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRpgaipnqdyleall

I-set Immunoglobulin I-set domain 191-267 7.3e-07 20.9 Pfam-A 7-80 (90) alignment
Range on Protein: 191-267
Range on HMM: 7-80/90.0
IQNVEVNAGQFATFQCSAIGRtVAGDRLWLQGiDVRDAPLKEIKVTSSRrFIASFNVVNTTKRDAGKYRCMIRTEGG
...|||. |. ....|.. |     .  |... .   .. ...||| .   .... . | ...|.|||.| .. . |
lkdvevseGesvelectveGe.pepsvsWakd.gselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsag

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 947-1067 9e-07 23.3 In-house 18-150 (290) alignment
Range on Protein: 947-1067
Range on HMM: 18-150/290.0
ENRMKNRYGNIIAyDHSRVRLQTIEGDTNSDYINGNYIDgYHRPNHYIATQGPMQET-------IYDFWRMVWHENTASIIMVTNLVEVGRV----KCCK
.. |..|. . ..  ..|| |.      |.|||  |..  .    . |.|| | ...       | .|| |.  |.  ...|. .  |  .      | |
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPDDTE---IYKDIKVTLIETELLAEYVIRTFAV
| |.  .    .|...|   . |   .  .|.  |
YvpesvgeelkfkgltvkCkskekeddvetRelvv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 947-1050 1.1e-06 22.3 In-house 50-151 (302) alignment
Range on Protein: 947-1050
Range on HMM: 50-151/302.0
ENRMKNRYGNIIAYDHSRVRLQTiegdTNSDYINGNYIDGYHRPNHYIATQGPMQETI---YDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDDTEI
.|  ||.  .. ..|. .|.|..    .. .|.|.  ..  .  .  | .| | ...     .|||||..|. .|. ..    |. .    ...|  .. 
knlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

YKDIKVT
||. .  
ykeygkm

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1426-1490 1.1e-06 22.6 In-house 264-343 (350) alignment
Range on Protein: 1426-1490
Range on HMM: 264-343/350.0
RTVVHCLNGGGRSGTFCAISIVCE---ML----RHQR-------TVD-VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
  .|||  | || ||....  . .   .|    .. |       | | ..  |. ||. . .||  |||. |.|| .| |
pilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1304-1470 1.2e-06 22.2 In-house 98-267 (302) alignment
Range on Protein: 1304-1470
Range on HMM: 98-267/302.0
HPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN--GVHRHGPIQVEF--VSADLEEDIISRIFRIYNAAR-----PQDGYRMVQQFQFLG
 |  .|.. .| |. .|. . || | ..  |  . | .|. ..  |. . |   |.   |  ||||    . |..|.         ..  . |. ..| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPMYrDTPVSKRSFLKLIRQVDKWQEEynggegrTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK
|| .  .|    . |....  . ....        .||| .| ||.||. ||    ..  .... |. . |. .|. .
wpdh.Gapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcr

DUF1191 Protein of unknown function (DUF1191) 698-804 1.5e-06 14.5 Pfam-A 138-250 (278) alignment
Range on Protein: 698-804
Range on HMM: 138-250/278.0
YRIYFQAASRANG--ETKIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAAT-PKPVPEP----EKQTDHTVK-IAGVIAGILLFVII-FLGVVLV
 |. |. ||.|..  ...  || .. .. . ...  ...      .|.  |   ..  || .||    ||.  .. | . .|. |. | ... .| ||.|
irvdFsdassasqpgasaarcvvfelngeatiseqvksnvCatsrqGhyalvvkseakkpkvepegesekeklsrWkvvgsvvgGvvllgllavlvvvvv

MKKRklaKKRKETMSS
  ||   ||..| |  
rakr...kkkreemer

PepSY_TM_3 PepSY-associated TM helix 768-790 2.6e-06 13.4 Pfam-A 10-32 (37) alignment
Range on Protein: 768-790
Range on HMM: 10-32/37.0
IAGVIAGILLFVIIFLGVVLVMK
..|...|.||..... |.| | .
WlGlalglllllwflsGlvmvfr

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1427-1491 3.5e-06 20.6 In-house 268-344 (349) alignment
Range on Protein: 1427-1491
Range on HMM: 268-344/349.0
TVVHCLNGGGRSGTFCAISIVCEMLRH-----------QRTVD-VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 .|||  | ||.|... . .. ..|             . . | .. .| .||  . .||  | |. ..||  |.|.
llvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

DctM DctM-like transporters 767-812 5e-06 11.5 Pfam-A 171-216 (416) alignment
Range on Protein: 767-812
Range on HMM: 171-216/416.0
KIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVM
 .|..|.|.||.|...| |... ||..| .| |... . .| .   
faaalipglllavglllavaiaakkenlssktkaelkrllqalkea

Ig_3 Immunoglobulin domain 193-263 6.2e-06 18.3 Pfam-A 10-74 (75) alignment
Range on Protein: 193-263
Range on HMM: 10-74/75.0
NVEVNAGQfATFQCSAIGRTVaGDRLWLQgidvRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIR
......|   |..||| |     .... .    .. | .  .. .|.   ..... ..|  | | |.|...
ptvtsggn.vtLtCsaeggpp.pptisWy....ietppelqgsegssssestLtissvtsedsGtYtCvas

PTEN_1 1353-1443 6.3e-06 21.1 In-house 52-149 (196) alignment
Range on Protein: 1353-1443
Range on HMM: 52-149/196.0
QVEFVSADLEEDIISRIFRIYNAARPQDG----Y----RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFCA
....|.|||..   . |. ..| .   .     |    .. .....|  |.  ... | ..... ..... |  . .  ..  .|||  | ||||| .|
slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva

fn3 Fibronectin type III domain 383-466 6.9e-06 19.3 Pfam-A 3-80 (85) alignment
Range on Protein: 383-466
Range on HMM: 3-80/85.0
PRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVhycYQVGGQEqvrEEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEG
|. | | || |...|..|.|   .     .|....    ..||.|   |... .........|.|.| |.|. ....   | .|
PenlsvsevtstsltlsWsppkdgggpitgYevey...rekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngag

Ig_2 Immunoglobulin domain 192-278 7.5e-06 17.9 Pfam-A 7-80 (80) alignment
Range on Protein: 192-278
Range on HMM: 7-80/80.0
QNVEVNAGQFATFQCSAIGRTVAgDRLWLQGidvrDaplKEIKvtSSRR--FIasfnvVNTTKRDAGKYRCMIRTEGGVGISNYAELVV
....|..|.  |. |.| |.  . .  | ..    .   .|..  .|..  ||      |..  |.|.|.|. . ..|   ||. |. |
pptvvtegenvtLtCqapgnptp.kvqwykd....g...eels..qsqnalfi.....pnvsaedsGtYtCrasnsegskqsnsvevtv