Gene PTPRM in Homo sapiens

Synonym: PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu, PTPRM

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRK
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP102_AA protein Get Run
HsapP102_AA_907-1198 phosphatase_domain Get Run
HsapP102_AA_1210-1492 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRK_pd Subfamily PTPRK 902-1234 2.4e-178 586.7 In-house 1-314 (314) alignment 
Range on Protein: 902-1234
Range on HMM: 1-314/314.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGqsapWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
|||||||||||.|...|.||||||||||||.|||    ||.|||||||.|||.|.|.|||.|||.|.||.||..|||||...||.|.||...|.||||.|
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevSQRGVHEIREIRQFHFT
||..||||.|..||.|||.|.|.|||||||||.||||.|||.|.||||.|.|||||||.|.|.|.|||               ..||..||||.|||.|.
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrvek...............largqeeirevrqfqfl

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||||.||..|||||..||.||......||..||||||||||||.||.|||.|||.|||||||..|.|..||||.||||.|||||.||.|.||||||||.
gWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
|..|.|....||.....|||||||||.||||.|
taipvsefkalylesirldpqtnssqlkeefqt
subfamily_PTPRD_pd Subfamily PTPRD 902-1273 1.5e-146 484.3 In-house 2-356 (564) alignment 
Range on Protein: 902-1273
Range on HMM: 2-356/564.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
...| ||.| .|. ..|  ... |.|||... |||. .|..|.|..|..|||| ||.|||||||.|...||| .||||| ..||||.....|||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHF
||| ||||||| .|...|.|.|.|.| |.||| ||||.. || | ...||| |.| ||.|.|||| ..|                    .| ||.|||||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.................ssesreVrqFhF

TGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCG
| ||||||| .||.|| ..|.|.. ..| |||.||||||| ||||.|||||.||. .. |..||||..|..||. |  ||||||||.|||.|||||  ||
tsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

DTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNmVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPF
.|.|.......    ... ...|...... ||. |.  .    .|. . |  |.|..|||  .||. ..|   
ntevesenlkqhlqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvv
subfamily_PTPRK_pd Subfamily PTPRK 1254-1489 6.2e-115 378.3 In-house 42-275 (314) alignment 
Range on Protein: 1254-1489
Range on HMM: 42-275/314.0
RNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVdPAQL---CPQYWPENGVHrH
 |.||||..|||..||...|||||||. ||.||||||.||||.|.||||||.||..|||||||||.|..|.|.|||...  ..    | .||||.. . .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev.y

GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEyngGEGRTVVHCLNGGGRSGTFCAISIVCE
|.|.||.|...|......||||....||.|...|.|.||||||||.. |.|||....|||.|.|.|.|||   ..||.||||..|.||.|||.||.||..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivld

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|......||||.||||||..|.|||.  .||||.|.|.||
mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 905-1234 2.3e-109 360.3 In-house 2-317 (318) alignment 
Range on Protein: 905-1234
Range on HMM: 2-317/318.0
IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET
| | || .|. ...      ..|||| .  . ... .  . .. |..|||| ||.||||.||.||..||...||||| ||||||.| . |||.|.|. ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsQRGVHEIREIRQFHFTG
| |||||||  |.| |.|.|...| |..|. .|||.. .. |....|.| |.  |..||.|.| |.                 .....| |..||.|.| 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvt.................rteeeesrqvrqyhyts

WPDHGVPYHATGLLGFVRQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||.||| ....|| .||||..   ...|||.||||||| |||| ||..||.|. .. |..||... |..||..|  |||||.||.||.|..|||  .||
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
| | ||..||   .... ||..  .... ||. 
tevdasdlrsrirelreqdpesgttemdaefqr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 905-1232 2.2e-101 334.1 In-house 5-318 (319) alignment 
Range on Protein: 905-1232
Range on HMM: 5-318/319.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
|.|..| ....... .   ....|.. . |...  .|||.|.||. |||| ||.|||..|| |....|  .||||| ..||||.. . .||||.|...||
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-EIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancsPSREVSQrgvheiREIRQFHFTGW
 |||||||.|..  ..|.|.||| ..||. ||||. . | |  . ||| | | |..|.|| . ..|           | ||        ||. .|..| |
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnk..........kssevet......RevkhfqyteW

PDHGVPYHATGLLGFVRQVK-SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
|||.|| .||.|| ...... |.. ...||.|||||||.|||| |||.|.||.  ..|||.|... |..||  |  |||..||| ||..|.|||  .|||
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

SVPASQVRSLYYDMNKLDPQTNSSQIKEEF
 .   ..|    .... ...|  .... ||
eievqdlrdrlkqlaekvadtgetgleref
0040438 (Phosphotyrosine protein) phosphatases II 909-1233 2.5e-101 334.3 In-house 4-312 (317) alignment 
Range on Protein: 909-1233
Range on HMM: 4-312/317.0
DLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW
|||... ...    ....||.| . . .  ... |.. ||. |||| .|. ||||||.|. ..|| .||||| .|.||.......||||||...|..|||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHG
||||.... .|.|.|.|.| ||.||..||| ..|  |.|..|||...| ||....||. ||. |                   | |....||.|||||||
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd.................sesrtvthfhytgWpdhg

VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPAS
||.. . || |...|... ... ||..|||||| ||||.||....||.. |.|| ||....|.|||..| ..|||.|||.|..||.|| .....|..|||
vppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepas

QVRSLYYDMNKLDPQTNSSQIKEEFR
.  .... .   ....... ...|..
elklkllklliplalddvklkekelk
0051299 (Phosphotyrosine protein) phosphatases II 904-1197 8e-101 332.5 In-house 4-286 (288) alignment 
Range on Protein: 904-1197
Range on HMM: 4-286/288.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQE
.|.| .||... ...    .|..||.| ... . . .. .|.. ||. |||| .|..||||||.|....|. .||||| .|||||......||||||...
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGeancspsrevsqrGVHEIREIRQFHFT
|..|||||||..|.  |.|.|.||| ||.||..||| .....|.||.|||...| |..|..||. |.. .  .             | .| |....||.|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.............gdgesrtvthfhyt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
.||||||| ... || |.|.|... ... || ||||||| ||||.||..|..|.. |.||.||... |. ||..| .||||.|||.|...|.||..
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 902-1232 2.3e-99 327.3 In-house 3-314 (315) alignment 
Range on Protein: 902-1232
Range on HMM: 3-314/315.0
HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
|  | . .|. ...| |..   |||..|||   ||  | | ||| ||. |||| ||||||.|||.|  .| | .|||.| |.|||| ....|||.|||  
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFavekggaggeancspsrevSQRGVHEIREIRQFHFT
... ||||.|..|. . |.|.|||||  . |. |||||.  ||  | ||... |   || .||.                   |     .|||. |.|.|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...................svvfgdnirevvqlhyt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
 ||| ||| ... |. ..|.||     |.|..||||||| |||| || .| .|| || | ..|.|| .. .|. |..|||. ||| ||.||.||. .|||
swpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd

TSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
||.        |  .    |.| |. ..|.|
tsiaqdlylqrydsllapspdtgstllqeqf
subfamily_PTPRG_pd Subfamily PTPRG 905-1215 4e-99 327.3 In-house 1-305 (563) alignment 
Range on Protein: 905-1215
Range on HMM: 1-305/563.0
IRVADLLQHITQMKCAEGYGFKEEYE---SFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPM
. | .. .|...... .  ||.||.|   |    .. . ....| ||. |||| ||.|||.|||.|. . |  .  |||| ||||||.. . .||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEANcspsrevsqrgVHEIREIRQFH
..|. |||||.| .|.| |.|.||||| || ||  ||| | .| |. ..|||||.| || | .||. ...     . .            .. ...||.|
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq...........cdteklvrqyh

FTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
.| ||||||| |..  | ||.. .   .  |||.|||||||.|||| .||.| .|   ..| .|.... .. .|..| ..|||||||.|.|||.||| . 
ytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

GDTSVPASQVRSLYYD
..| . |.||..|   
ketellaeqveelknc
subfamily_PTPRA_pd Subfamily PTPRA 901-1232 1e-98 325.3 In-house 10-330 (330) alignment 
Range on Protein: 901-1232
Range on HMM: 10-330/330.0
LHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEG-QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGP
 .. . | .| . | . .. .   |.||....  |   |  . |.|.||. |||. ||. ||.||| |...||  .|||||  .||||.. ...||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

MQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE-IYKDIKVTLIETELLAEYVIRTFAVEKGGAGgeanCspsREvsqrgvHEIREIRQF
 .||. |||||.|  ..|.|.|.|.| |  . || .||||.    | .|.|.. ....| .| .| | |.. . .    .   ||      .. | .|||
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpda....t...re......kksrlvrqf

HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||.||| ||| .. |.| ....||.. . ||||.|||||||.|||| |||.| .|.. . |..||... |..|| .| .||||.|||.||. ..||  |
hftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

CGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
 ||| . .| . .    . .  ..|.   ..|||
ygdteldvsslekhlqklynkitgtdkigleeef
0050432 (Phosphotyrosine protein) phosphatases II 899-1201 1.1e-98 325.7 In-house 20-303 (308) alignment 
Range on Protein: 899-1201
Range on HMM: 20-303/308.0
GQLHPAIRVADLLQHITQmkCAEGYGFKEEYESFFEGQS-APWDSAKKDENRMKNRYGNIIAYDHSRVRLqtiegDTNSDYINGNYIDGY--HRPNHYIA
 . .  ..| |||... .    . ....||.| ... .   ....|.. ||. |||| .|..||||||.|     | .||||| .|.|||  ..|...||
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIa

TQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD----DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHE
||||...|..|||||||..|.  |.|.|.||| ||.||..|||.    ....|....|||...| |..|..||. ... |                   |
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.................dge

IREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPsaGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHD
 |....||.|.||||||| ... || |...|... |.  || ||||||| ||||.||..|..|.. |.|| ||....|. ||..| .||||.|||.|...
srtvthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

AILEACLCGD
|.|| ...  
alleylklkl
subfamily_PTPRB_pd Subfamily PTPRB 904-1197 3.1e-98 323.4 In-house 6-285 (293) alignment 
Range on Protein: 904-1197
Range on HMM: 6-285/293.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQE
 |.. .. .|...||  . ..|.||||.. . |..   ..|.. .|| |||| ||..||||||.|........||||| |||.||. |...||||||. |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD--TEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqrgVHEIREIRQFHF
|. ||||||| ...  |.|.|.||| |.||| .|||.|  . .| ||||||...| | ..|||....||                    .|.|..||.||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...................ekeerkvrqyhf

TGWPDHGVPYHATGLLGFVRQVKSKS--PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
| ||||||| ... || |||.|...     |..|.||||||| |||| || .| .|.  |.| .|||.  | |||..|...||||.||.|||...|. .
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0043336 (Phosphotyrosine protein) phosphatases II 905-1195 7.4e-98 322.6 In-house 2-275 (278) alignment 
Range on Protein: 905-1195
Range on HMM: 2-275/278.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
|.| |||... ... .. .....|.|.. . .  ... |.. ||. |||| .|..||||||.|. ..|| .||||| .|.|||..|...||||||..||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGgeancspsrevsqrgvhEIREIRQFHFTGWP
.|||||||.... .|.|.|.||| |||||..|||.... |.|..|||...| |. |..||. |.. | |                 | |.....|..|||
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdg.................esrtvthyhylgwp

DHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|||||.. . || |...|... ..| ||..|||||| ||||.||.....|...|.|| ||....|.|||..| ..|||..||.|...|.||
dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 925-1202 6.6e-96 316.3 In-house 2-279 (284) alignment 
Range on Protein: 925-1202
Range on HMM: 2-279/284.0
FKEEYESFFEGQSA---PWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYINGNYIDGY-----HRPNHYIATQGPMQETIYDFWRMVWHEN
..||.|     .     ... |.. ||. |||| .|..||||||.|....||  .||||| .|.|||     ......||||||...|..|||||||..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TASIIMVTNLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHAT
.  |.|.|.||| ||.||..|||  ... .|.|..|||...|    |..||. ... |                   | |....||.|.||||||| ...
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy................tgesrtvthfhytswpdhgvppspe

GLLGFVRQVKSKSP--PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREG---VVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
 || |.|.|..  .  |. || ||||||| ||||.||..|..|.. |.||   .||....|. ||..| .||||.|||.|...|.||..... |
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 925-1210 4.1e-95 313.8 In-house 15-290 (297) alignment 
Range on Protein: 925-1210
Range on HMM: 15-290/297.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
...|.|.... . . ... |.. ||. |||| .|..|||.||.|    .| .|||||..|.|||......||||||...|..|||||||..|. .|.|.|
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETEL--LAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGF
.||| ||.||..|||   ...  |.|..|||...|   |..|..||. |.. |                   | |....||.||||||||| ... || |
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn.................gesrtvthfhytgwpdhgvpespaslldf

VRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE---REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVR
...|..  |  || || .|||||| ||.|.||..|.||.. |   .|| |||...|..||..| ..|||.|||.|...|.|| .....| .|.... 
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 914-1204 1e-94 312.2 In-house 18-297 (298) alignment 
Range on Protein: 914-1204
Range on HMM: 18-297/298.0
ITQMKCAEGYGFKEEYESFFEGQS----APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWR
 . .|  .  |...|.. . ...|    . .. |.|.||. |||| .|||.|.|||.|.....| .|||||  ....|.. | .||||.|..||. ||||
aavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWr

MVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGV
||..|. ..|.|.|||.|....|. |||||  .| | .|.|.| ..|  |....|...|.|                 . ... ||.||.||| |||.||
mvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvsk.................kkeekerevrqlhftsWpdkgv

PYHATGLLGFVRQVKSkSPPSAG--PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV
| .|| .|...|.|.  |.  ||  |..|.|||| ||.| ||.|| .|. ...| |||... |. || .|...||||||||||..|.|||  .... .
penatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045450 (Phosphotyrosine protein) phosphatases II 901-1198 9.7e-94 309.8 In-house 5-305 (307) alignment 
Range on Protein: 901-1198
Range on HMM: 5-305/307.0
LHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQS---APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYINGNYI--------DGYH
|.. |.. .||... ...    .|...|.|.... .     ....|.. ||. |||| .|..|||.||.|....|.  .|||||..|.        |||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD--TEIYKDIKVTLIETELLAEYVIRTFAVEKG-GAGgeancspsrevs
.....||||||..||..|||||.|....  |.|.|.||| ||.||..||||.  .  |....|||...| |..|..||. |.   | |            
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg............

qrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMV
     | |....||.||||||||| .   || |...|..  .. |. || .|||||| ||||.||....||.. |.||.   ||....|..||..| ..|
.....esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

QTEEQYVFIHDAILEACL
|..|||.|...|.|| .|
qnpeqyrflyeallelll
0039614 (Phosphotyrosine protein) phosphatases II 906-1201 1.7e-93 308.6 In-house 15-293 (297) alignment 
Range on Protein: 906-1201
Range on HMM: 15-293/297.0
RVADLLQHITQMKCAEGYGFKEEYESFFEGQSaPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG-DTNSDYINGNYIDGYHR-PNHYIATQGPMQET
..  | ...  .|. . .....|.|.  . .  ..  |.. ||. |||| .|..||||||.|....| | .||||| .|.|||.. ....||||||..||
plsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IYDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgvhEIREIRQFHFTGW
..|||||||.... .|.|.|.||| || ||..|||.... |.|..|||...| |. |..||. |...|                   | |....|..|||
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnng...................esrtvthfqytgw

PDHGVPYHATGLLGFVRQVKSKSP--PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|||||| ... || |...|..     |. || .|||||| ||||.||....||.. |.|| ||....|.|||..| ..|||..||.|..||.|| .....
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 905-1213 1.2e-91 302.0 In-house 4-299 (305) alignment 
Range on Protein: 905-1213
Range on HMM: 4-299/305.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGqSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI
| ..|| ..|..... .  |....|.|. |  . . |  ||..|. |||. .|. .|..|..|.. | . .||||| .|.|||.| ..||..|||...|.
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI---YKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFT
 ||||....| . .|.|.|.||| |. || .|||. .     . ...|.| ...  ..|..| . . .                    .| | . |...|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede................dkesrtvlqyqlt

GWPDHGVPYHATGLLGFVRQVKSKSPPSAG-PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCG
 |||||||  || || ....|. .   . | ||.|||||| |||| ||..||.|. ...|.|||... ...|||.|..|||| .||||.|||. |   ||
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

DTSVPASQVRSLY
|||.  | .|   
dtsiigsnlrarv
subfamily_Ptp69D_pd Subfamily Ptp69D 903-1211 1.5e-91 301.8 In-house 2-300 (307) alignment 
Range on Protein: 903-1211
Range on HMM: 2-300/307.0
PAIRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQ
.|| . || . ... |    .|...|||.  .   .     ..|.|| .|||| .|.|.|. ||.|..|.|. .||||| ..| ||.  ...|| |.|..
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGA-GGEAncspsrevsqrgvHEIREIRQFH
.|| |||||..  .   |.|..|| |  | || |||| .|.  | || |.|...|   .|.||.. | | .. .||              .. |.. |.|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev.............edsrkvvqyh

FTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
.|||.|  || .|.||| ...||..    . .|.|||||||.||.| |. .|..|.  . |  |||.. |..|||.|  .||  |||||.. |.|.    
ytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

GDTSVPASQVRS
||| .   .. .
gdtdedvddled
0047943 (Phosphotyrosine protein) phosphatases II 924-1196 1.9e-91 301.6 In-house 13-271 (273) alignment 
Range on Protein: 924-1196
Range on HMM: 13-271/273.0
GFKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV
...||.| ... . . ..  |.. ||. |||| .|..||||||.|    || .||||| .|.|||......||||||...|..|||||||..|.  |.|.
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

TNLVEVGRVKCCKYWPDD----TEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGF
|.||| ||.||..|||..    ...|....|||...|  . |..||. ... |                  .| |....||.||||||||| . . || |
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.................tgesrtvthfhytgwpdhgvppslesllef

VRQVKSKSPP--SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
...|...     | || ||||||| ||||.||..|..||. |.|| ||....|. |||.| .||||.|||.|...|.|| 
ielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
DSPc_SM00195 925-1196 2.8e-89 294.3 In-house 2-261 (263) alignment 
Range on Protein: 925-1196
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
.|||.|.  | . . . ..|.|..|. |||| ||. |||.||.|...|....||||| |||.|......|||||||...|. |||||||.|..  |.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLA-EYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFV
. .| |. || .|||..   .| ...|.|.|.|.|    |...||. ..| |                  .| |...|.....||||||| ... .| ..
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................eetrkvtqyqyknWpdhgvpdstksvlell

RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|.||...  | ||.||||||| ||||.|..|||.|.  |.|  ||| ..|.|||. | .||||.||| ||..||||.
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 925-1196 2.8e-89 294.3 In-house 2-261 (263) alignment 
Range on Protein: 925-1196
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
.|||.|.  | . . . ..|.|..|. |||| ||. |||.||.|...|....||||| |||.|......|||||||...|. |||||||.|..  |.|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLA-EYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFV
. .| |. || .|||..   .| ...|.|.|.|.|    |...||. ..| |                  .| |...|.....||||||| ... .| ..
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................eetrkvtqyqyknWpdhgvpdstksvlell

RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|.||...  | ||.||||||| ||||.|..|||.|.  |.|  ||| ..|.|||. | .||||.||| ||..||||.
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 911-1195 4.8e-87 286.7 In-house 9-277 (288) alignment 
Range on Protein: 911-1195
Range on HMM: 9-277/288.0
LQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWR
........  .  ||.|||.|    ...   . ... .|  |||| ||..||. ||.|.  |  ...|||| .||||... ..|||||||...|. |||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsqRGVHEiREIRQFHFTGWPDHG
.|. ..|  |.|.|.||| |. || .||||. .   | ...|||.|.. | ..| |.. .|                  .  .| .|| |.....|||||
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..................kkkte.leitqyqylaWpdhg

VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||  .. ||...||||  ..  .||..|||||| |||| ||..| ..|. |.| ..|. . | .|| .| ..|||..||.||....|.
vPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 910-1196 1.4e-85 281.8 In-house 2-275 (281) alignment 
Range on Protein: 910-1196
Range on HMM: 2-275/281.0
LLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW
| .|. |..  .  ||.||||.. . |.. .  ..|.|||..|||| ||.|||..||...  | ..|.|||| |...||. ...|||||||. .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT--EIYKDIKVTLIETELLAEYVIRTFAVEKGGagGeancspsrevsqrgvhEIREIRQFHFTGWPDH
.||| ..   |.|||. .| |..|| .|||||.   .| |..|. ...|  |.|. |.| .|. .  |                | ||..|...| ||||
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres..g................etreveqlaytaWPdh

GVPYHATGLLGFVRQV-KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|||  .. ||.| ..| | ... .  |||.||||| ||||..| .| ... .|.|   .|. . |.||| .|  ||||  || |.. |.|.|
GvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
Y_phosphatase Protein-tyrosine phosphatase 948-1195 3e-85 280.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 948-1195
Range on HMM: 1-235/235.0
NRMKNRYGNIIAYDHSRVRLqtiEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEI
|. |||| .|..||..||.|   .|... ||||| ||..||......||||||...|| |||||||.|.. .|.|.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YKDIKVTLI-ETE-LLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
|.||||.|  ...   .||..|.. ..| ..                  | ||..|.|.|.||||||| ....|| ..|.|.... .. ||.|||||||.
ygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||||.|...||.|...|.|. ||....|.|||..| .|||..|||.|...||||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 948-1195 3e-85 280.7 In-house 1-235 (235) alignment 
Range on Protein: 948-1195
Range on HMM: 1-235/235.0
NRMKNRYGNIIAYDHSRVRLqtiEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEI
|. |||| .|..||..||.|   .|... ||||| ||..||......||||||...|| |||||||.|.. .|.|.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YKDIKVTLI-ETE-LLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
|.||||.|  ...   .||..|.. ..| ..                  | ||..|.|.|.||||||| ....|| ..|.|.... .. ||.|||||||.
ygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||||.|...||.|...|.|. ||....|.|||..| .|||..|||.|...||||
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 943-1199 8.4e-85 279.0 In-house 4-244 (250) alignment 
Range on Protein: 943-1199
Range on HMM: 4-244/250.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVkCCKYWP-DDT
||| .|. |||| .|||.|.||| |.. .|| .|||||  ...||.  . .||||||.|.|| ||||||..|....|.|.|||.| ... . .||| . .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspSREVSQrgvheiREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP-SAGPLVVHCSAG
|.| |..|.| ..|  |.|..|.. . |            .. ..      | .||.||. ||| ||| .||  |.....|... .   ..|..|.||||
ekyGdvtvsllskeefadytkrklklsk...........akkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaG

AGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC
 ||.|.||.|| .|. ...| |||... .. ||  |...|...|||||.. .||.|  .
vgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0040439 (Phosphotyrosine protein) phosphatases II 940-1198 1.3e-83 275.6 In-house 3-247 (249) alignment 
Range on Protein: 940-1198
Range on HMM: 3-247/249.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-
.. |.. ||. |||| .|..||||||.|. ..|   ||||| .|||||......||||||..||..|||||.|...  .|.|.|.||| ||.||..||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVH
...  |.|..|||...| ...|..||. ... .                   | |.......|.||||||| .   || |...|..  .. |. ||..||
ggsleygdftvtllsvevkddytvrtleltnly.................dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVH

CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||| ||||.||....||.. |.|. ||....|..|||.| ..||..|||.|...|.|| .|
CsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0050432 (Phosphotyrosine protein) phosphatases II 1194-1492 4.8e-83 274.3 In-house 9-300 (308) alignment 
Range on Protein: 1194-1492
Range on HMM: 9-300/308.0
LEACLCGDTSVPASQVRSLYYDMNK-LDPQTNSSQIKEEFRTLNMVTPtlrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitidGESSNYINAALMDS
||..|..|||...|  .  ..|. | |..........|||..|..|.|   ....|.||||.|..||| .|||| |..  .|    .|.|.|||| ..| 
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdg

Y--KQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPEN---GVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqdGYRMV
|  |.| .||.||.||||||.||||.| ..... .|||.. .    . |.||||..   |. ..|...|...| . ..|.. | ... |   .   .|.|
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtv

QQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE
..|....||   ..| | ...|.....|.|..     ..| .|||| .| ||.|||.|. ...|.|.....||||.|||.||  .|.||  ..||.|.|.
thfhytnWp.dhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

VALEYLN
..||||.
alleylk
0042113 (Phosphotyrosine protein) phosphatases II 941-1195 1.7e-82 271.8 In-house 2-241 (245) alignment 
Range on Protein: 941-1195
Range on HMM: 2-241/245.0
DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-D
..|.. ||. |||| .|..|||.||.|. ..||  ||||| .|.|||......||||||..||. |||||.|...  .|.|.|...| |||||..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSP-PSAGPLVVHCS
..  |.|..|||...| |..|..||. |..                  | .| ||....|...||||||| .   || |.. |..    .| ||..||||
esltygdftvtllseehlddytvrtlevtnl.................gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|| ||||.||....||...|.|. |.....|.||||.| ..|||..||.|...|.||
aGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 1200-1491 6.9e-82 270.4 In-house 1-286 (288) alignment 
Range on Protein: 1200-1491
Range on HMM: 1-286/288.0
GDTSVPASQVRSLYYDMNkldpQTNSSQIKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSA
|||.........|.. .     ... ....|||..|  ..|.    ..|.|||| |.|||| .|||| |..  .| ..|| |.|.|||| ..| |... .
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--ARPQDGYRMVQQFQFLGWP
||.||.||||||.||||.| ..... .|||....  .   |.||||..|.  .|.|.|...| . ..|.. | ... |    .... .|.|..|....||
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

mYRDTPVSKRSFLKLIRQVDKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   ..| | ...|...|.|.|...    |.| .|||| .| ||.|||.|. ...|.|.....|||..|||.||. .|.||  ..||.|.||..||||
.dhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 922-1201 1.2e-81 269.4 In-house 7-276 (278) alignment 
Range on Protein: 922-1201
Range on HMM: 7-276/278.0
GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRlqtiegdtnsDYINGNYIDGYhrPNHYIATQGPMQETIYDFWRMVWHENTASIIM
.  . | .. .  |.   .  | . .|. |||| .|..||||||.          |||| .|||||  |...||||||...|. |||||.|.... .|.|
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTNLVEVGRVKCCKYWPDDT-EIYKDIKVTLIETELLAEYVIRTFAVEKGG----AggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHA--TG
.|.||| ||.||..|||..  ..|.|..|||...| | .|..||. |.                          | |.....|...||||||| .   . 
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltvered.................lesrgvthlhylpwpdhgvpslpilks

LLGFVRQVKSKSP-------------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAerEGVVDIYNCVRELRSRRVN-MVQTEEQYVFIHDAILEACLCG
.| .......                .| || .|||||| ||||.......||..   ||.||....|.||||.| . .||..|||.|.....||  |.|
flellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

D
.
k
subfamily_PTPN6_pd Subfamily PTPN6 917-1194 1.6e-81 268.6 In-house 20-294 (306) alignment 
Range on Protein: 917-1194
Range on HMM: 20-294/306.0
MKCAEGYGFKEEYESFFEG---QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQtIEGDTNSDYINGNYIDGYH--RPNHYIATQGPMQETIYDFWRMV
 .  |  ||.||.|.. .    .    . ..| ||. |||| ||. .||.|| |.  .. ..|||||.|||..      ..|||||| ...|. ||||||
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

WHENTASIIMVTNLVEVGRVKCCKYWPDDT--EIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVP
| ||.  |.|.|. || |. ||..|||| .  | | .|.|| .. . ||.|..|.. |.|                 .  .| ||..|.||. |||||||
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk................kkkkeerevfqyhfksWPdhgvp

YHATGLLGFVRQVKSKSPPSA----GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
 .   .| |...|..|.  ..    ||.||||||| |||| ||||||.|.. |..|.   .||...|. .|. |  .||||.|| |.. || 
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 943-1212 1.5e-79 262.6 In-house 56-306 (319) alignment 
Range on Protein: 943-1212
Range on HMM: 56-306/319.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgRVKCCKYWPDDTE
|  |.|. |||..||.|.|...|.|. ..|   |||||  ...|| |.. |||.|||...|. |||||.|  |...|...|      . ||..||| ...
anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

I-YKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsRevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK---SKSPpSAGPLVVHCS
| ..  || .   |  ||||.| . . . |          .       ..||.|.|||| ||||.||| ... |. .|..|.   ||      ..|||||
ikeerfkvkvdsveetaeyvvrdielsedg..........k......ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken.hranivvhcs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSL
||.|||| .||.|..||. ..|  ||.|| ||.|| .| ..||   || ||. |.||  | | . |   .. . 
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 943-1214 6.1e-79 260.5 In-house 20-272 (284) alignment 
Range on Protein: 943-1214
Range on HMM: 20-272/284.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgRVKCCKYWPDDTE
|  |.|. |||.|.|.|.|...|.|. . |   |||||  .| || |.. |||||||...|. |||||.|  |...|...|      . ||..||| ...
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

I-YKDIKVTLIETELLAEYVIRTFAVEKGGaggeancspsRevsqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK---SKSpPSAGPLVVHCS
| ..  || .   |  .|||.| . . . |          .       ..||.|||||| ||||.||| ... |. .|..|.   ||      ..|||||
ikeerfkvkvdsveeseeyvvrdielsedg..........k......ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcs

AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYY
||.|||| .||.|..||. ..|  ||.|| ||.|| .| ..||   || ||. |.||  | | . |   .. . . 
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle
0036941 (Phosphotyrosine protein) phosphatases II 1217-1492 1.6e-78 259.3 In-house 4-278 (297) alignment 
Range on Protein: 1217-1492
Range on HMM: 4-278/297.0
NKLDPQTNSSQIKEEFRTLnmvTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRL
..|...........||..|   .| |   ..|.||||.| |||| .|||| |..   |   |.|.|.|||| ..| |... .||.||.|||||| ||||.
kllekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VLDYHCTSVVMLNDVDPAQL--CPQYWPEN--GVHRHGPIQVEFVSADL--EEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLI
|.....|..|||..... .   |.||||..  ..  .|...|...| .   ..|.. | .....     .  |.|..|...||| . ..| | .|.|..|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdh.gvpespaslldfi

RQVDKWQEEYNGGeGRTVVHCLNGGGRSGTFCAISIVCEMLR---HQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
..|.|.......| |...||| .| ||||||.|. .....|.   ....||.. |||.||. .|..|  |.||.|.||. ||.|.
elvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0039614 (Phosphotyrosine protein) phosphatases II 1214-1492 6e-78 257.6 In-house 20-290 (297) alignment 
Range on Protein: 1214-1492
Range on HMM: 20-290/297.0
YDMNKLDPQTNSSQIKEEFRTLNMVTPtlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALMDSYKQ-PSAFIVTQHPLPNTV
  ...|...........|| .|  ..|     |.|||||| | .||| .|||| |..   | ..||  ..|.|||| ..| |.. . .||.||.|||.||
dlllllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

KDFWRLVLDYHCTSVVMLNDVDPAQL-CPQYWPENGVhRHGPIQVEFVSADLEEDIISRIFRIYNaarpQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKL
.||||.| ....|..|||.. .. .  |.|||||.|  ..|...|.... . ..... | ... |     .  |.|..||..|||   ..| | ...|..
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwp.dhgvppslelllef

IRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
...|.....|. ...|...||| .| ||.|||.|. ...|.|.. ..|||..|||.||. .|..|  ..||.|.|...||.|.
lelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0047943 (Phosphotyrosine protein) phosphatases II 1218-1491 7.5e-78 257.0 In-house 4-272 (273) alignment 
Range on Protein: 1218-1491
Range on HMM: 4-272/273.0
KLDPQTNSSQIKEEFRTLNMVTPtlrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV
.|..........|||..|  ..|   . ..|.||||.|..||| .|||| |..  .|   ....|.|||| ..| |... .||.||.||||||.||||.|
llekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

LDYHCTSVVMLNDVDPAQL--CPQYWPENG---VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdgYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQ
 ..... .|||....  .   |.||||..|   . ..|...|...| . ..|.. | ....|   ..  .|.|..|...|||   ..| |  |.|..|..
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwp.dhgvppslesllefiel

VDKWQEEYNGGeGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
|.|..|..... | .|||| .| ||.|||.|. .....|.. ..|||. ||| ||. .|.||  ..||.|.||..||||
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 1228-1492 1.1e-77 256.5 In-house 2-275 (284) alignment 
Range on Protein: 1228-1492
Range on HMM: 2-275/284.0
IKEEFRTLNMVTPTLRvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALMDSY-----KQPSAFIVTQHPLPNTVKDFWRLVLDY
..|||..|...|..|   ..|.|||| |..||| .|||| |..  .| ..||  |.|.|||| ..| |     ... .||.||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

HCTSVVMLNDVDPAQ--LCPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIYNAaRPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQ
... .|||.. .  .   |.||||..| | ..|...|...| . ..|.. | ... |   . . .|.|..|....||  ...| | ...|...|.|....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswp.dhgvppspedlleflrlvrell

EEyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. ..|.| .|||| .| ||.|||.|. ...|.|....   .|||..||| ||. .|.||  |.||.|.||..||||.
en.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 925-1241 2.7e-77 255.0 In-house 20-320 (515) alignment 
Range on Protein: 925-1241
Range on HMM: 20-320/515.0
FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
| ||.  .   .  |   |... |  ||||.||. || .||.|. |. . .|||.|  || ...  . |||.||| . .. ||||.|..||.. |.|||.
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

LVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ
| |  ..|| |||||   |.  .  ||| |. .|  .. ..|.. | ||                    ..| . |||||.|||.||| |.. || ....
lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg...................ddsrtvtqfhfteWPdkGvpkhtssllklike

VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDP
||..    . ||..|||||.|||| .| || ..  |.   .||..| |. .| .|. .|||.||| ||..|.||  |  .| .|  .      |.     
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

QTNSSQIKEEFRTLNMVTPT
    |.. .||.||. ..| 
grgrskmtkefqtlkslcpd
0037934 (Phosphotyrosine protein) phosphatases II 940-1195 4e-77 254.3 In-house 2-240 (243) alignment 
Range on Protein: 940-1195
Range on HMM: 2-240/243.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLqtieGDtnSDYINGNYIDGYhrpNHYIATQGPMQETIYD----FWRMVWHENTASIIMVTNLVEVGRVKCCK
.  |.. ||. |||| .|..||||||.|    ..  |||||.|.|...   ...||||||..||. |    ||||.|.... .|.|.|.||| ||.||..
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDDTeIYKDIKVTLIETELLAEYVIRTFAVEkggaggeancspsrevsQ-RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK--------S
|||...  |.|..|||...| |..|..||. .|                      .. |.....|...||||||| . . || |...|..          
ywpgev.tygdftvtllseehlddytvrtllle.................nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellslla

PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAereGvVDIYNCVRELRSRRVN-MVQTEEQYVFIHDAILE
 .| ||..|||||| ||||..|....||..    | ||....|..||..| . .|||..||.|...|.||
ldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 943-1196 4.2e-77 253.5 In-house 2-239 (239) alignment 
Range on Protein: 943-1196
Range on HMM: 2-239/239.0
AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT
|||  |. |||| ||..|||||| |. .  |  ||||| .|.  |   |. |||||| .. .  |||||.|.|  . |.|.| |.|  . || .|||| |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EIYKDIKVTLIETELLAEYVIRTFAvekggaggeancspsreVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGA
  | ...||| .||..|.|.||||                  .|| |  | | . |.||| |||.||| .|| .||. |..   | | | | |.||||| 
skycnlrvtlrktevfadyiirtfv.................msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||||.|.||| ||  |...  |||.| |. .|  |  |||| ||||||| |.|||
grtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 942-1195 8.9e-77 252.4 In-house 2-239 (239) alignment 
Range on Protein: 942-1195
Range on HMM: 2-239/239.0
SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD
.|||  |. |||| ||..|||||| |. .  |  ||||| .|.  |   |. |||||| .. .  |||||.|.|  . |.|.| |.|  . || .|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TEIYKDIKVTLIETELLAEYVIRTFAvekggaggeancspsreVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAG
|  | ...||| .||..|.|.||||                  .|| |  | | . |.||| |||.||| .|| .||. |..   | | | | |.|||||
tskycnlrvtlrktevfadyiirtfv.................msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsag

AGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
 ||||.|.||| ||  |...  |||.| |. .|  |  |||| ||||||| |.||
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1201-1494 1.1e-76 253.0 In-house 2-293 (298) alignment 
Range on Protein: 1201-1494
Range on HMM: 2-293/298.0
DTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAF
.| . |.... .   ... ..... .. ..||..|| |. ... |  ..|  |.|..||| .||.. | .   | ..|  | |.||||. ...||. .||
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqdGYRMVQQFQFLGWPMyR
|.||.||..||.||||.| ... ...|||...   .   ...|||..| ...| |.|.  | .   |.|.| . . .. .   . |.|.|..|  ||  .
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd.k

DTPVSKRSFLKLIRQVDKWQEeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
..|  ..| |.|.|.| ..|.  . |.   .|.| .| ||||||.||. | | ......||||..||.||...|..|.  .||.|.||. ||.|.|.
gvpenatsvldllrkvrasqq..qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 925-1235 2.1e-76 251.8 In-house 21-315 (315) alignment 
Range on Protein: 925-1235
Range on HMM: 21-315/315.0
FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
| ||.  . . .  .  .|....|  ||||.||. .|..||.|. |. . .|||||  || ...  . |||.||| . .. ||||||..|....|.|||.
fseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ
. |  ..|| .||||   |.  .  |||.|...|  .. |.| . . |.                   .| | . ||.||.|||.||. ... || ....
kqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks...................eesrtvtqfqftewPdkGvdkqtssllklike

VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDP
||..  .   .|.||||||.|||| .| || ... ..|. .||..| |..||. |. .|||||.| ||.||.||  |  .| ..  ..     |..    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

QTNSSQIKEEFRTL
 .  |.. .||.||
gsgrskmtkefetl
subfamily_PTPN9_pd Subfamily PTPN9 908-1197 2.1e-75 248.5 In-house 4-290 (297) alignment 
Range on Protein: 908-1197
Range on HMM: 4-290/297.0
ADLLQHITQMKcaeGYGFKEEYESFFEG-QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYD
 .|.... ...     | ..||.   .   .   . .|.  |  |||| ... ||..|| |.....|..||||| |..|||.... .||||||...|. |
eelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsreVSQrgvHEIREIRQFHFTGW
|||||| ...  |.|.| .|| ||.|| .|||   .... . |..|. .|.|   .|..|.. ...              | .   .|.|..  | |..|
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn..............vkt...eesrkvthfqflsW

PDHGVPYHATGLLGFVRQVKS-------------KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
||.|||  |. || ....|..             | .||  |.||||||| |||| || .|| |.  |..|.||. ..|. ||..|  ..||.|||.| .
PdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcy

DAILEAC
 |.||  
lavleya
subfamily_PTPN12_pd Subfamily PTPN12 936-1197 3.3e-75 247.7 In-house 28-277 (290) alignment 
Range on Protein: 936-1197
Range on HMM: 28-277/290.0
QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
.  . ....|.||. |||| .|. ||.||| |..||.. .|||||.|.| | . . .|||.|||. .|. |||||.|. |.  ..|. ..||.|. || .
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDDTE--I-YKDIKVTLIETELLA-EYVIRTFAVEKGgaggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAG
|||. .|  . . ...|||.| . .  ...|||..||.                    .| |...|||.| |||||||  |. || ....|..    .. 
YWpeegeeelefgefevtleeekavdddflirtLkveaq...................kesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||||||||| ||||  |.||.. .. ..| .   .|... |.||| .|. .|||.|||.... |..| .
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0040438 (Phosphotyrosine protein) phosphatases II 1224-1492 7.8e-75 247.4 In-house 16-277 (317) alignment 
Range on Protein: 1224-1492
Range on HMM: 16-277/317.0
NSSQIKEEFRTLNMVtptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC
.  ...|||..|  .     ....|.|.|| |..||| .|||| |..   |  ..| ..|.|||| ..| .... .||.||.|||||| ||||.| ....
dftalleefedllsl....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

TSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEey
|..|||.. .. .   | ||||....  .|...|...| . ...|. | .....     .  |.|..|...|||   ..| | ...|.....|....|  
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWp.dhgvppspdllldfleavreale..

nGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 ...| ..||| .| ||.|||.|. ...|.|.. ..|||..|||.||. .|..|  ..||.|.|...||||.
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0045450 (Phosphotyrosine protein) phosphatases II 1214-1492 3.7e-74 245.5 In-house 15-305 (307) alignment 
Range on Protein: 1214-1492
Range on HMM: 15-305/307.0
YDMNKLDPQTNSSQIKEEFRTLNMVTPTLrVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG--ESSNYINAALM--------DSYKQPSAFIVTQ
. . .|..... . ...||..|. ||..| . ..|||||| |..||| .|||| |..   | ..||  |.|.||||  .        |.|... .||.||
lllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

HPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVH-RHGPIQVEFVSADLEEDIISRIFRIYNAaRPQDGYRMVQQFQFLGWPmYRDTP
.|||.||.||||.. ....| .|||.. ..   . |.||||..| .  .|...|...| . ..... | ... .  .. .  |.|..|...|||   ..|
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwp.dhgvp

VSKRSFLKLIRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 |  ..|..|..|.|..||. ...|...|||  | ||.|||.|. .....|... |   ||...|||.||. .|..|  ..||.|.||..||.|.
psfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPRD_pd Subfamily PTPRD 1253-1494 1.2e-72 240.4 In-house 46-284 (564) alignment 
Range on Protein: 1253-1494
Range on HMM: 46-284/564.0
PRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRH
| | .|||  .|.. |..   | ...| |.|.||||  .|.|... |.| ||.||..|..||||.| .......|||. .   .   | .||||.|  ..
paNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety

GPIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCE
| ..|....    .|.. | |.. ..   ..  |.|.||.|  ||  .. | | .|.|.|||.| ...|    ..| .|||| .| ||.|||..|... |
geltVtleeeeeladyeirtfklkkkk..ssesreVrqFhFtsWPd.hgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamle

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
 .....|||..  ||.||.... ||.  .|| |..|. ||.|..|
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
0043336 (Phosphotyrosine protein) phosphatases II 1223-1491 4.2e-72 238.2 In-house 17-277 (278) alignment 
Range on Protein: 1223-1491
Range on HMM: 17-277/278.0
TNSSQIKEEFRTLNMVTPtlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYH
.. . ...|| .|. ...    ...|||||| |..||| .|||| |...  |  ..|. .|.|||| ..| |..| .||.||.|||.||.||||.| ...
nlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

CTSVVMLNDVDPAQL--CPQYWPeNGVHRHGPIQVEFVSADLEEDIISRIFRIYNaaRPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEe
.|..|||.. .  .   | |||| .|. ..|...|.... . ..|.. | ... |  .  . .|.|.....||||   ..| |  ..|.....|....| 
vttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale.

ynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
    .| ..||| .| ||.|||.|. ...|.|.. ..||...|||.||. .|..|  ..||.|.||..||||
..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 904-1232 2.3e-70 232.3 In-house 4-323 (325) alignment 
Range on Protein: 904-1232
Range on HMM: 4-323/325.0
AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET
.| | .|..|. . |. .  ||  |..     ..     | | ||. |||. |..|.|.||| |.| . |..||||| .|.  . . . ..|.| |. .|
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

IYDFWRMV--WHentASIIMVTNLVEVGRVKCCKYWPDD---TEIYKDIKVTLIETELLAEYVIRTFAVeKGGAGGeancspsrevsqrgvhEIREIRQF
| |.||.|  |.   .|...|.| .. |  .|..|||..   .  .  ..| |.  | ...|| | . | |.  .|                | | ..||
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv.kqvkkG................etrsvkqf

HFTGWPDHGVPYHATGLLGFVRQVKSKS------PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDA
.. .|.| ||. . . |. ... ||  |        ...|..|||||| |||| || .  .|.    |  |||.. |. ||  | .||.| .||..|..|
qlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea

ILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF
. || ..|.| || | . .    ... .| |.  .|..||
lveaymsgntdvpvssfeaklsslqernpltqklniekef
subfamily_CG7180_pd Subfamily CG7180 1226-1491 3.6e-70 230.9 In-house 13-290 (296) alignment 
Range on Protein: 1226-1491
Range on HMM: 13-290/296.0
SQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
 . . |.. .  .||.|. .||  .|   | ||||  ...|.|   ..| ..|||. |.||||. .||. .. ..|||. |  .||..||||| | .. .
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--------ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDK
||.| .  | |...|.|||... ...|.| || |. .   .. .| |...          .  .   |.|..||.  |..    |.|  ....|.|.| .
vvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

WQEEY--NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
|.|.   .  || .||.. .|..||| ..|| .  |.....  ||||.||||||...|..|.  ..||..|.| ||..
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 947-1195 5.1e-70 230.4 In-house 2-237 (237) alignment 
Range on Protein: 947-1195
Range on HMM: 2-237/237.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDtnSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD--DTEI
||..|||||||.||||||| |.   ..  ||||| .|..|.   |..|||.|||.. .  |||.||| |. . |.|.| |.|  ..|| ||||.  . . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YKDIKVTLIETELLAEYVIRTFAVEKGGAGGeancspsrevsqrgvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP--SAGPLVVHCSAGA
|  . |.|   | ...| .|.. . | .                   |.| | |..|| |||.||| ... || | ...  .||    .|| ..||||| 
ygvltvslkkkeefsdytvrslllskrltlk................evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagv

GRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|||| |.||| ||  |. . |||||| |  .   |  ..||..||||||..|||
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 947-1194 6e-69 227.2 In-house 27-265 (274) alignment 
Range on Protein: 947-1194
Range on HMM: 27-265/274.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTN-SDYINGNYIDGYHR-PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI-
 .  |||| .|.  ..||| |.. ... . |.||| ||| ||..  . |.|||||...|. |||||...|..  |.|.|.| |  . || .|.||.... 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

----YKDIKVTLIETELLAEYVIRTFAVEKGGAGGEancspsrevsqrgvheireIRQFHFTGWPDHGVPYHATGLLGFVRQVKS---KSPPSAGPLVVH
    |.|....  ..    .| .|.. ...     .                   .  . .| |||| .| .|. || .|..|..   ..   ..| |||
iserygdveikvekiverndysvrklvlkylerers...................vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvh

CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
|||| ||||||| |.| .   ..|.|||. . | .||  |  ||||.||| .|| |. 
CsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
DSPc_SM00195 1227-1491 9e-69 227.1 In-house 1-262 (263) alignment 
Range on Protein: 1227-1491
Range on HMM: 1-262/263.0
QIKEEFRTLNMVTPTLrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
..||||..|.. |..    ... |  ..|..|||  .||| |.    | .... |.|.||||  .. .......|.||.|||.||.||||.|.. ... .
klkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMLNDVDP--AQLCPQYWPEN--GVHRHGPIQVEFVSADLEE-DIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY
|||.. .    . | .||||.  |  ..| |.|..|. . .. .|| | ... . ..  .  | |.|.|. .||   ..| |..|.|.|.|.|.|.... 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

nggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   .| .|||| .| ||.|||..|.|... |... .||.|. || ||...|.||. |.||.|.||..|||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1227-1491 9e-69 227.1 In-house 1-262 (263) alignment 
Range on Protein: 1227-1491
Range on HMM: 1-262/263.0
QIKEEFRTLNMVTPTLrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
..||||..|.. |..    ... |  ..|..|||  .||| |.    | .... |.|.||||  .. .......|.||.|||.||.||||.|.. ... .
klkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMLNDVDP--AQLCPQYWPEN--GVHRHGPIQVEFVSADLEE-DIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY
|||.. .    . | .||||.  |  ..| |.|..|. . .. .|| | ... . ..  .  | |.|.|. .||   ..| |..|.|.|.|.|.|.... 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

nggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
   .| .|||| .| ||.|||..|.|... |... .||.|. || ||...|.||. |.||.|.||..|||.
...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 1246-1492 1e-68 226.9 In-house 2-247 (249) alignment 
Range on Protein: 1246-1492
Range on HMM: 2-247/249.0
DCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP
..|.|||| |..||| .||||.|.. . |  ..| . |.|||| ..| |... .||.||.|||.||.||||.. ....|..|||.. ..   . | ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEYnGGEGRTVVHCLNGGGRSGTFC
..|.  .| ..|...| . ..|.. | ....|     .  |.|...|...||   ..| |  ..|..|..|.|..||. . .|...||| .| ||.|||.
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. ...|.|.. ..||...|||.||. .|..|  ..||.|.||..||.|.
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_CG7180_pd Subfamily CG7180 942-1201 1.9e-67 222.0 In-house 36-294 (296) alignment 
Range on Protein: 942-1201
Range on HMM: 36-294/296.0
SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDD-
 . . ||| |||. ... ||. || |....|. .|||||  |.|.. ... || |..|..||. .|||.|. |.. .....|.  .  . .. .||| . 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

TEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeanCSPSREVSQRGVHEIREIRQFHFTGWPD-HGVPYHATGLLGFVRQVKS---KS--PPSAGPLV
 | |..| | ..|.. .|. .|||| . |             |  .  . | | ...|..| |.  . ||. ...|. ..|.|..   |    |  ||.|
keqygeifveiveekqyanlkirtfkltkk.......ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGD
|..| ||.|.| .. ||. |...|.|. ||... |. ||  | ..|.. |.| .| | .||| ||. 
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
0045098 (Phosphotyrosine protein) phosphatases II 1240-1492 4.7e-67 221.6 In-house 18-273 (278) alignment 
Range on Protein: 1240-1492
Range on HMM: 18-273/278.0
PTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFlitidgessNYINAALMDSYkqPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLC
..  . ... ||.. | .||| .|||| |..  .         .|||| ..|.|  | .||.||.|||.|| ||||.. ....|..|||... .   . |
llgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

PQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY--RMVQQFQFLGWPMYrDTPVSK--RSFLKLIRQVDKWQE----------EYNGG
.|||||.|. ..|...|...| .  .|.. | ....|    . ..  | |.....|.|| . ..| .   .|||.|.........           ....
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllssllllds

EGRTVVHCLNGGGRSGTFCAISIVCEMLrhQRTVDVFHAVKTLRNNKPN-MVDLLDQYKFCYEVALEYLN
.|...|||  | ||.||..|. ...|.|  ...||...|||.||. .|. .|  |.||.|.||..||.|.
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN3_pd Subfamily PTPN3 940-1196 1.4e-66 219.3 In-house 33-274 (280) alignment 
Range on Protein: 940-1196
Range on HMM: 33-274/280.0
WDSAKKDENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYID----GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
 . |.| ||  |||| .|..||. ||.|.    ....|||| ||..    . .  |.|||||||...|  |||.|||....  |.|.|.||| |||||..
isaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDDTE--IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPL
|||. ..   | ...|.. ...   .||.| . ...                 .  .| |.| |. .. ||||||| ... .| ||..|...   .  |.
yWPetedeleygefsvkcekedetksyvlrelvlkd.................ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePv

VVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||||||| |||| .|.... | . |..  | . . ||..| .| ..|||..|| |. .|||..
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 927-1208 3.1e-66 218.5 In-house 30-295 (297) alignment 
Range on Protein: 927-1208
Range on HMM: 30-295/297.0
EEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRpnHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLV
||.    | .  |   |.|  |  |.|| ||. || |||.|. .. | .|||.|  .. |..   ..|.|| ||..|. |||.||..|... |.|.... 
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

EVGRvKCCKYWPDDTE-IYKDIKVTLIETELLAEYVIRTFAVEKGGAggeancspsrevsqrgvHEIREIRQFHFTGWPDHGVPY--HATGLLGFVRQVK
|  . || .||.|..   . |. |.|  ..    .. |.. |.|| |                    | ..|..|. |||. |.   .|. || .. .|.
erdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka.................karrvvkqyqfveWPdkaverkdsassllklisevr

SKSP-PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQ
 .    . |||.|||.|| |||| .. || ..  |.||  |||.. |. ||  |...|||.||| |.. |.||| |. || ..|| 
kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
Y_phosphatase Protein-tyrosine phosphatase 1255-1489 4.7e-66 217.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 1255-1489
Range on HMM: 1-235/235.0
NHEKNRCMDILPPDRCLPFLiTIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP--ENGVHRHG
|..|||  |||| |.    | . ....|.||||  ...||....||.||.||..|..||||.|........|||....    . |.||||  |..  ..|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC
 |.|| .  . . |.... | ... . ....   |.|.|... .||  ...| |..|.|.|||.| |..   .  .| .|||| .| ||.|||.|..|..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|.|.....|||...||.||...|.||. |.||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1255-1489 4.7e-66 217.9 In-house 1-235 (235) alignment 
Range on Protein: 1255-1489
Range on HMM: 1-235/235.0
NHEKNRCMDILPPDRCLPFLiTIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWP--ENGVHRHG
|..|||  |||| |.    | . ....|.||||  ...||....||.||.||..|..||||.|........|||....    . |.||||  |..  ..|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC
 |.|| .  . . |.... | ... . ....   |.|.|... .||  ...| |..|.|.|||.| |..   .  .| .|||| .| ||.|||.|..|..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
|.|.....|||...||.||...|.||. |.||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0042113 (Phosphotyrosine protein) phosphatases II 1247-1492 5.4e-66 217.8 In-house 1-244 (245) alignment 
Range on Protein: 1247-1492
Range on HMM: 1-244/245.0
CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPE
.|.|||| |..||| .|||| |...  |  ..|.  |.|||| ..| |...  ||.||.|||.||.||||.. ....|..|||.. ..   . |.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

NGVHRHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCA
... ..| ..|...| . ..|.. |.... |   . | .|.|.....|.||   ..| . ...|.... |.|...|  ...|...|||  | ||.|||.|
gesltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia

ISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
. ...|.|.. ..|....||| ||. .|..|  ..||.|.||..||.|.
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 905-1197 6.9e-66 217.1 In-house 2-283 (290) alignment 
Range on Protein: 905-1197
Range on HMM: 2-283/290.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAP-WDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD--TNSDYINGNYIDGYHRPNHYIATQGPMQ
|.| .. ..... .     ||.......  |.|      .   .|. .||. ||. ||  |. |. | |.   . .|||  ||.||.  ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEAncspsrevsqrgvheiREIRQFHF
.|. |||...|.|... |.|.|| .| |.||| .||||  |. |  ....|.. | | ||..|.. |..  ..|..                ... |...
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagak................qsvtqyqi

TGWPDHG-VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
| |...| |. ..| || . ...| .  .  ...|||||.. ||.. |..... .. .. |||.|... ....|. . ..|||..|| .|.. .|.. 
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 946-1204 7.7e-66 217.0 In-house 45-285 (287) alignment 
Range on Protein: 946-1204
Range on HMM: 45-285/287.0
DENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-EIY
 .|. |||. .|. .|  || |.    ... ||||  .||||.  ...|....|| .|. .||......|   |.|.... |  . .| .|||...  ..
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

KDIKVTLIETELLAEYVIRTFAVEKGGAGGEAncspsrevsqrgvheiREIRQFHFTGWPDHG-VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR
 . ...|.. |  |.|..|.. |.. .  |.                 ....|...| |...| |. ..| || . ...|..  .. ...|||||.. ||
Geyniellneevnagyierklevknknkagdk................qqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV
.. |. ... .. ...|||.|... ... | .. ..||| ||| || |..||   ...| .
samfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 912-1208 9e-66 217.1 In-house 9-290 (439) alignment 
Range on Protein: 912-1208
Range on HMM: 9-290/439.0
QHITQMKCAEGYGFKEEYESFfEGQSAPW----DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDF
.|. ...  .   |||..|.  .  | ..      | .. .. |||| .. |.||.|| || | |   | ||| |||.||. .. ||||||| .||  ||
ehvekldknkqeifkeifeki.nstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddf

WRMVWHENTASIIMVTNLVEVGRvkcckYWPDDTEIY-KDIKVTLIETELLAEYVIRTFAVEKggaggeancspSREVSQRGvheiREIRQFHFTGWPDH
||.|....|. |.|.|||||  .     ||| |.|..  || |       | .|||| | | .            |. ...     | . |||.. |||.
wrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfn...........erdtteke....rtvlqfhyiawpdk

GVPYHATGLLGFVRQVKSKSP-PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVP
 || .|. .| |.| ..|       ||.||||||| ||||  | .|| |.    |  |||   |. || .| .|||.  |||||..|.||    ||..| 
nvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt

ASQ
  .
ide
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 918-1196 3.2e-65 214.8 In-house 10-292 (301) alignment 
Range on Protein: 918-1196
Range on HMM: 10-292/301.0
KCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHEN
 ...  .|.|.|..  ||.. . .   ..||.. ||. ||  ||. |. |.. .    .. .||| .||||| . ...||.||||..|. ||||..|.| 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

TASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGagGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGV-PYH
..||.||||| |  . || .|||.   ..| .  ..|||...  . ..||| ..|      |  | .  |..  .  .. ... |.. | ||..|| . .
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd..gsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

ATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.| |     ... .  .. ||.|||||.. .|.| .. ..| |. . .|||||... .. .|  .  .|.| |||..|.|.| . 
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_PTPN13_pd Subfamily PTPN13 941-1196 6.6e-65 214.1 In-house 30-268 (273) alignment 
Range on Protein: 941-1196
Range on HMM: 30-268/273.0
DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsdYINGNYIDGYH--RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP
...||.||. |||| |.. ||..||.|.   |     ||| ..|         .|||.|||. ||. |||.|||  ..  |.|||. .| |.||| .|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

DDTE----IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPpSAGPLV
. ..    ..  ..|.|.... | ..|.|..||..                     | ||. ...|. ||||||| .|. || ||..|..    .|||.|
esknkklkvsnrlevellkvqkldgfvvralavkd.................sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPiv

VHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|||||| ||.| .|.||..|.. ||.  .|. . ||.|| .|  .|||..||.|.. ||||.
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 924-1234 4.2e-63 208.1 In-house 21-273 (392) alignment 
Range on Protein: 924-1234
Range on HMM: 21-273/392.0
GFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT
 | ||.  . . .  |  .|.|. |  ||||.||. || .||.|. |.  ..|||.|  ||....  . |||.|||   .. ||||||..||...|.|||
lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

NLVEVGrvkcckywpddteiykdikvtlietellaeyvirtfavekggaggeancspsrevsqrGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK
.| |                                                              .. | . ||||| |||..|| |.. || |...||
klkegd..........................................................kgddartvaqfhftewPdkdvpkhtssllkfikevk

SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK-LDPQ
..    . ||..||||| ||||  | || ..  |..  .||..| | ..| .|  ||||.||| ||. |.||  |  .| .|  ..     |..   | .
adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGd

TNSSQIKeEFRT
..| |.| |||.
vrskqlk.efrs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1249-1493 1.1e-62 206.5 In-house 3-244 (250) alignment 
Range on Protein: 1249-1493
Range on HMM: 3-244/250.0
IALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD-PAQLCPQYWPENGV
.|  |.|.|||| .||.. | .   | . .  . |.||||. ...|.. .|||.||.||..|..||||.||... ...|||...    . ..|||| .. 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

HRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISI
...| ..|.  | .   |...| . . .| .   . |.|.|..|. ||  .  |   .. |.|...| . |..   |..  .|.| .| ||||.|.||. 
ekyGdvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPd.kgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaida

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
| | |.....||||. .|.||...|..|. |.|| |.||..|..|.|
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN1_pd Subfamily PTPN1 937-1204 2.7e-62 205.1 In-house 21-280 (290) alignment 
Range on Protein: 937-1204
Range on HMM: 21-280/290.0
SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKY
  |  .||..||| .||| ..  |||||..|.  .     |||| . ..  .   .|| ||||. .|.  ||.|||.... ...|. ..|| ...|| .|
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDDTE----IYK--DIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS--PP
|| . |    ...   .||.||..|   .|..|.. .|.                 .  .| ||| .||.| ||| |||   . .| |. .|..     .
wPqgeeekellledtklkvkliseerksyytvrllelen.................lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE--ACLCGDTSV
  || |.||||| ||.| |...| .|   |...    ||| . . |||. |. ..|| .|  | . ||||   .. ||.||
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1250-1494 2.8e-62 205.6 In-house 41-283 (318) alignment 
Range on Protein: 1250-1494
Range on HMM: 41-283/318.0
ALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGV
.| | |. ||| ..||. |..   | ...|| .|.||||  .| |..  |.| .| |||.|..||||.| . ... .||| ..     . . .|||..| 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

HRHGPIQVEFVSADLEEDIISRIFRIYNaaRPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISI
. .| ..||  .    .| . | |.. .  . ..  |.|.|...  ||  ...| |  |.|.|.|||.|.|..   |.| .||||  | || |.|.|..|
rsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpd.egvpesgaslldlvrqvskaqqks..gagpivvhCsaGvGrtGvfiavdi

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
. | .... .||||. ||.||.... ||   |||.|.|.| ||.|.||
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1212-1494 3.2e-62 205.5 In-house 10-286 (319) alignment 
Range on Protein: 1212-1494
Range on HMM: 10-286/319.0
LYYDMNKLDPqTNSSQIKEEFRTLNMVTPTlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTV
|   ...|.  | . ....||..|.. ...    . . |  ..|..|||  .||. ||.   | ..|| |.|.||||. .|.|.. ..|| || || ||.
Lkerlkalas.tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

KDFWRLVLDYHCTSVVMLNDV-DPAQL-CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIyNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLK
.||||.| ....  ||||... .. .. . .||||. ... | . |.  . .  ||.| | . . | .  .   |.|..||.. ||   | | . .| |.
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpd.hdvPekatslld

LIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
|.... | .|.    .|  |||| .| || |||...... | .... ..|||. |..||  .. ||.  .||||.||. ||....|
llkrirksrekt..qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_PTPRA_pd Subfamily PTPRA 1225-1491 3.9e-62 205.0 In-house 31-295 (330) alignment 
Range on Protein: 1225-1491
Range on HMM: 31-295/330.0
SSQIKEEFRTLNMVTptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
. ...||| .|   .       . .|    |.|||| ..||| |    .| ...|. .|.||||. .| ||.   || .| |. .||.||||.. ... .
nklfreefnalPagp...iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksa

SVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA--ARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEE
..||| ...    . | ||||..|.  .| |.||     . .|.  | | . .   |. ..  |.|.|| | .||     |.  .  |||...| | .. 
tivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqq

YNGgegRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
. |     ||||  | ||.|||.... | |... .| ||||..|| ||...|.||  . ||.|.|.| ||| 
sag...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 947-1195 6.2e-62 204.0 In-house 19-262 (270) alignment 
Range on Protein: 947-1195
Range on HMM: 19-262/270.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDdteiyk
 ..  ||| .|.   ..||||...| | .. ||| ||. |.. ....|||..||.. |. .||||.|.|.. .|.|.|.|.| || || .|||       
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa......

dikvT------LietellAEYVIRTFAVEKGGAGGeaNCSPSREVSQRGvhEIREIRQFHFTGWPDHGVPYHAT------GLLGFVRQVKS--KSPPSAG
           |      ..  |...|...  . |        .. ..|  |.|..  |... ||||||| ..        ||  .|.|.   |.   |.
....epkekvkl......edgkikvlalseekeeg..yiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
||.|||||| ||||..|..||.. . |... ||. . ..|||  |...||. ||| |.. |..|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0037934 (Phosphotyrosine protein) phosphatases II 1246-1491 1.2e-61 203.7 In-house 1-242 (243) alignment 
Range on Protein: 1246-1491
Range on HMM: 1-242/243.0
DCSIALLPRNHEKNRCMDILPPDRCLPFLitiDGesSNYINAALMDSYKQpsaFIVTQHPLPNTVKD----FWRLVLDYHCTSVVMLNDVD--PAQLCPQ
..|||||| |..||| .|||| |.   .|   .|  |.|||| |.. ...   .|.||.|||.||.|    |||.. ....|..|||.. .   .. |.|
sfsiallpenlsknrysdilpydhsrvkl...eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPeNGVhRHGPIQVEFVSADLEEDIISRIFRIYNaARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEE-----YNGGEGRTVVHCLNG
||| ..| ..|...|...|    .|.. | ....|   ..| .|.|.....|.||   ..| |  ..|.....| ...||     .. ..|...|||  |
ywp.gev.tygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

GGRSGTFCAISIVCEMLrhqrTVDVFHAVKTLRNNKPN-MVDLLDQYKFCYEVALEYL
 ||.||..|. .....|    .||...|||.||. .|. .|  ..||.|.||..||.|
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1217-1489 7.1e-59 194.7 In-house 25-289 (319) alignment 
Range on Protein: 1217-1489
Range on HMM: 25-289/319.0
NKLDPQTNSSQIKEEFRTLNMVTPTLrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR
|| | . . .... ||| .  ... |   | . | |..| .||| ..||. |.    |  ..| | |.||||. .. |...  .| .| ||.||..||||
nksdfdddltklevefrracklgvnl..adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

LVLDYHCTSVVMLNdvdpAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDK
.. .|.|...|.|      . | |||| ..| ...  .|.  | .  .. . | ... . .. . . | ..|| ||||| .   | .   ...|...| .
miweyncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdv.Gvpdypsdlmrlvkkvrh

WQEEYNGgEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
 ..  |. .   ||||  | ||.|.. .. .. ....... |||.. |. ||......|. | ||||.|   ||
ltskenh.ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1222-1489 1.2e-58 193.5 In-house 17-277 (288) alignment 
Range on Protein: 1222-1489
Range on HMM: 17-277/288.0
QTNSSQIKEEFRTLnmvTPTLRVEDCSIALLPRNHEKNRCMDILPPDrCLPFLITI--DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD
..| ....||...|   ..  . .. ... |..|..|||  .||| |   .  ..   ......||||. .|..|.  ..| || ||..||.|||.|| .
arnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YHCTSVVMLNDV--DPAQLCPQYWPENGV-HRHGPIQVEFVSADLEEDIISRIFRIYnaarPQDGYRMVQQFQFLGWPMYRdTPVSKRSFLKLIRQVDKW
.. . .|||...  .  . | .|||...  ...| ..|. |.   .||.. | . .      . . . ..|.|.|.||     | ||. .|.|.|||.  
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhg.vPeskapllellrqvkva

QEEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
...     |. .||| .| ||.||| |.  . ...... ..||. .|. ||......|. | || |.||| |.
nqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Ptp69D_pd Subfamily Ptp69D 1213-1492 9.4e-58 190.7 In-house 10-287 (307) alignment 
Range on Protein: 1213-1492
Range on HMM: 10-287/307.0
YYDMNKLDPQTNSSQIKeEFRTLNMVtptLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVK
  .... . .|.   .| |...|.         .....    |  |||  || . |.    | .| | |.|.||||  . .||.   ||. | |. .|..
eealksrkrdtdfglak.eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatig

DFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAAR---PQDGYRMVQQFQFLGWPmYRDTPVSKRSF
||||.. . . | .||| ...  .   |..|||..   ..| | |..|| .  .| | | . . .        .  | | |....||.     | . |. 
DfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargl

LKLIRQVDKWQEEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
||||.|| . ..     ..  |||| .| ||||.| |.... . |.   .||.|. || ||.... .|. |.||.|.|   |.| .
lklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1241-1494 3.2e-57 189.1 In-house 34-291 (325) alignment 
Range on Protein: 1241-1494
Range on HMM: 34-291/325.0
TLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QLCP
.       .| .| | .|||  .... |.  . | |  |  ||.||||. . ..|.   |. .| ||..|..|.||||||..|. ||.|| .|   . | 
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrca

QYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFRIynaARPQDG-YRMVQQFQFLGWP--MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLN
.|||..     . |...|......   | . |.. .    ....|  | |.|||. .|.    .  | .  |.|.|. .|..       . .  .||| .
vywpkemgksktfGglevklrtieeisdyvhrvldv...kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
| ||.|.| ..  . . . ..  ||.|  || ||...|.||.  ||| ..||   |.. ||
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1244-1489 1.2e-56 187.3 In-house 14-253 (284) alignment 
Range on Protein: 1244-1489
Range on HMM: 14-253/284.0
VEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNdvdpAQLCPQYWP
  | . | |..| .||| ..||. |.    |  ..| | |.||||. .  |...  .| || ||.||..||||.. .|.|...|.|      . | ||||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcsqywp

ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFC
 ..| ...  .|.  | .  |. . | ... . .. . . | ..|| ||||| .   | .   ...|...| . ..  |. .   ||||  | ||.|.. 
lkivikeerfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdv.gvpdypsdlmrlvkkvrhltskenh.ranivvhcsagvgrtgvyi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
.. .. ....... |||.. |. ||......|. | ||||.|   ||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 934-1194 5e-56 184.6 In-house 24-274 (287) alignment 
Range on Protein: 934-1194
Range on HMM: 24-274/287.0
EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVrLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKC
|. .| . .|..  .  ||||.... .|..|| | . ||.  ||||| ||. .|.. . .||.|||.  |. ||||.|.....||.|..|  || .| ||
esstatfkaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

CKYWPDDtEIYK---DIKVTLIE-TELLAEYVIRTFAVekggaggeancspsrevSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV-----KS
 ||||.  |         |.|.. . .  || .|.. .                  .   .| | ..|...  |||....  | ||. || .|      .
ykywPer.evPmrvGGysvvlldydikePeygvralrl.................idletrearvvkqldllswPdkvlaPtavglirfvldvkqhiela

KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
..   .||||||...|.||.| .. . ..... |  | ||. . |  || .|  .||.  |. .. .|. 
rdasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 939-1209 8.1e-56 184.0 In-house 24-278 (283) alignment 
Range on Protein: 939-1209
Range on HMM: 24-278/283.0
PWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGdtnsDYINGNYID---GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK
. | |  |||. |||. .|...|  ||.|..       ||||  .|     |.. . ||..|.|...|. |||.||..|. ..|.|.|.| |  |.||..
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPDD-TEIYKDIKVTLIETELLAEYVIRTFAVEKGgaggeancspsrevsqR----GVHeireIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSA
||| . .| | .  ||| .      ..|. . . .                       .     .  . . .| . |       |. | . .  .     
yWPkrGsedyGeftvtlrkettsnsfiikelllrvn................ssakstll....lahyqvidWleygeqaiinslvkfnkvislqteskk

GPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQV
||.|||||.| |||. || .   .. |  | |||... |. .| .|. .||| .|| ..|...|| .||||| . | ..
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1224-1494 2e-55 183.1 In-house 20-286 (305) alignment 
Range on Protein: 1224-1494
Range on HMM: 20-286/305.0
NSSQIKEEFRTLNMVtPtlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC
...........| .  .    | . .     |..|||  .| . |     | . . .  |.||||. .|.||.  ..||.| ||.|||.|||||..... 
sdkgleaqykslyee.e....esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

TSVVMLNDV--DPAQLCPQYWPENGVH--RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQE
...||| ..  .  . | |||||.  .  ..|...||  |    .| | | ..| ..   ..  | | |.|.  ||     | .  |.|.||..| | |.
stivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededke.srtvlqyqltdWPd.hGvpqfatsllslikrvqkdqk

EynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
.  . .   .||| .| ||.|.|.|..|  | |..  .||||. .|.||.....||  |||| |....  |....|
k..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0051429 (Phosphotyrosine protein) phosphatases II 976-1209 3.3e-55 182.9 In-house 4-236 (272) alignment 
Range on Protein: 976-1209
Range on HMM: 4-236/272.0
SDYINGNYIDGYHR---PNHYIATQGPMQETIYDFWRMvWHENTASIIMVTNLVEVGRVKCCKYWP-------------DDTEIYKDIKVTLIETELLAE
|.||| ....||.|   |. .....||.. |. ||||. ....  .|.......|.||.|| .|||             . |  | .. |||...|||  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVIRTFAVEKGGAggeancspsrevsqrgVHEIREIRQFHFTGWPDHGVPYHAtgLLGFVRQVKSksppsAGPLVVHCSAGAGRTGCFIVIDIMLDMAER
|..|.. ...                    .|.||....|.|.|||||||..|  || ..... .      ||..|||||| .|||........|   ..
yilrellltllls................agearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsl

EGVVD--------IYNCVRELRSRRVNMVQTEEQYVFIHDAILEAcLCGDTSVPASQV
| .||        ....|.|||..| ..|||||||.|...|.||. |.. .||.|. .
etivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyl
subfamily_PTPN14_pd Subfamily PTPN14 909-1194 3.6e-55 182.1 In-house 10-293 (300) alignment 
Range on Protein: 909-1194
Range on HMM: 10-293/300.0
DLLQHITQMKCAEGYGFKeEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEgDTNSDYINGNYIDGY--HRPNHYIATQGPMQETIY
| . .| ..|  ||  |. |||   .  . |  ..|| .||  |||. ... |...||.|.. . .....|||   |      .  .||..|||.. |. 
dkrakilekkleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptk.enstgyinassikvsvggkersyivaqgPleltvq

DFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiyKDIKVTLIETELLAEYVIRTFAVekggaggeanCSPSREVSQRGVHEIREIRQFHFTGWPD
|||.||| .... |.|.|.  | |. |. ||.|....  |  .|.  . .. ....  . .|             . ..     .| |..  . .| |||
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles..kkktvefgkfkvttkfsedsdsv..........ittglklkhlpskeertvwhlqytDWpd

HGVPYHATGLLGFVRQVKSKS---P------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
||||   .| | ....|.|             |  |..||||||.||||  |. |...   | . ..|| . .. || .|  .|||  || |......
hgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
0041856 (Phosphotyrosine protein) phosphatases II 948-1202 5.9e-55 181.0 In-house 1-176 (182) alignment 
Range on Protein: 948-1202
Range on HMM: 1-176/182.0
NRMKNRYGNIIAYDHSRvrlqtiegdtNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTnlvevgrvkCCKYWPDDTeiykdi
|. |||| .|. |||||          ..|||| |...|.......||||||...|..||.||.....  .|...|         .. |||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

kvtlietellaeyvirtfavekggaggeancspsrevsqrgvheIREIRQFHFTGWPDHGVPYhATGLLGFVRQVKSksppSAGPLVVHCSAGAGRTGCF
                                             |.. |.....|||||||     || |...|..    . || .|||||| ||||..
............................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtl

IVIDIMLDMaereGvVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDT
.....|. .    | |.....|...|||| .||.|..||.|...|.|| .|...|
vaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1250-1491 1.7e-54 179.9 In-house 44-279 (315) alignment 
Range on Protein: 1250-1491
Range on HMM: 44-279/315.0
ALLPRNHEKNRCMDILPPDRCLPFL-ITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENGV
|    |..||| ..|.. |.  ..| ..   . |.|.||...| |...  .| .| |....|||||||| ..... .|||...     . . .|||.. |
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkv

hRHGPIQVEFVSADLEEDIISRIFriynAARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISI
  .|.| |  .| . ....  | .    .   .|  | | |...  ||   . | .  ....|||.| .....     |  |||| .| ||.|||.... 
.iyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitlda

VCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
| . .  .. .||..... .|.|. .||. ..||.| |.. || .
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1254-1493 2.9e-54 179.2 In-house 50-286 (297) alignment 
Range on Protein: 1254-1493
Range on HMM: 50-286/297.0
RNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMDSYKQpsAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QLCPQYWPENGVHRHGP
 | ||.|  .||| |.    |  .. . .|.|.||. . ..|.   .| || | ..||.|||..|||.. . .||||| .   . | .||...||   | 
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGd

IQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRDTP-VSKRSFLKLIRQVDKWQEEYNGGegRTVVHCLNGGGRSGTFCAISIVCEM
. |.  | .  |  | | . . . .      |.|.|.||. ||        | .|.|||| .| |  .. . |    .||||.| || | ...|  |   
vsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvae

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 ... .||.|  || ||...|..|   .|||| |.. ||.| |
akrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPRN_pd Subfamily PTPRN 936-1195 1.7e-53 176.3 In-house 44-290 (297) alignment 
Range on Protein: 936-1195
Range on HMM: 44-290/297.0
QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI-DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC
. .  . ||...|  |||. ....||||||.|..   ...|||||   | |   |   |||||||. .|. |||.|||.. .. |...|.| | |  .| 
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

KYWPDD-TEIYKDIKVTLIETELLA-EYVIRTFAVEkggaggeaNcspsreVSqrgVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGP
.||||. .|.|.  .| |.   . . .|..|.| .         |      .     .| | . ||||  ||..|||  |  || | |.|       . |
rywpdeGsevyhiyevhlvsehiwcddylvrsfylk........n......lq...tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

LVVHCSAGAGRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
.|||||.||||||..|.||..|.        .||   .  || .| ..|.|..|. |.  |. |
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1216-1493 1.7e-53 176.5 In-house 10-280 (287) alignment 
Range on Protein: 1216-1493
Range on HMM: 10-280/287.0
MNKLDPQTNSSQIKEEFRTLNMVTptLRVEDCSIALLPRNHEKNRCMDILPPDRclpFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR
. . ...... . |. | .|. ||   | ..  ... ..|..|||  .||.||    . . . ||  .||||. .|.||.  |||... |. ||...||.
fvakghakgnegfknqftvleqvt..qredevthniasqnkdknRltqilvpdn...yrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWk

LVLDYHCTSVVMLND--VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRqv
|. | . | .||| .   .  . | |||||.     |. ..|... . ... | | ... |  . .|  ..|.|.|.  |.  .. .  . ..| . .  
liddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqtillviee..

dKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 . ....  |..  |||| .. |||..|||. .  .  . . ..|||  .|  |  ||..|   .|||| ... ||||.|
.myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN9_pd Subfamily PTPN9 1228-1491 9.4e-53 174.2 In-house 18-290 (297) alignment 
Range on Protein: 1228-1491
Range on HMM: 18-290/297.0
IKEEFRTLNMVTPTLRVedcSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVV
...|.  .   ... ..     . |. | ||||  |.|  |.   .| ..|. | |.||||  .| |||. ||| || ||..||.||||.| . ..  .|
lskeyaeirnepveGtf...lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLNDVDPA--QLCPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEY--
|   |       | ||||  |. ....| ..|. |. . |||   |.. |.|.    .  | |  ||||.|| |  .| |  |.|.....| . |     
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdy.GvPssaaslldvlekvrekqalavk

--------NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
        .  .   ||||  | ||.|||... |  . |... ||||...||.||. .  ..   .||.|||   ||| 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPRG_pd Subfamily PTPRG 1226-1493 1.6e-52 173.5 In-house 19-289 (563) alignment 
Range on Protein: 1226-1493
Range on HMM: 19-289/563.0
SQIKEEFRTLNMVTPTLRVeDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSN--YINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
  ..|||  |.. | .  . |.. .  | |..||| ..|.. ||    |  . |. ..  ||||  .| |..  |||.||.||..|..||||.. . . .
igfseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnva

SVVMLND--VDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYN---AARPQ-DGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQ
 .||. .   . .. |..|||.... . | .||  .. .      .| . | |    .  | |  ..|.|...  ||   ..| ..   |. ... .. .
iivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd.hgvPehslpvLifvkkssaan

EEYnggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
..     | .|||| .|.||.||..... . . .... .|.||. .|..| .....|   .|| | ... || ..|
kae...aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1254-1492 2.2e-52 172.8 In-house 42-277 (515) alignment 
Range on Protein: 1254-1492
Range on HMM: 42-277/515.0
RNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA-QL-CPQYWPE--NGVHR
 |..|||  .||| |.    |  | |   |.|.||. . |..   |.| .| |.. .|.|||||||... | ..|...     .  | .|||.      .
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

HGPIQVEFVSADLEEDIISRIFRIYnaaRPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISIVC
 | |.|| || .   . | | ...    . .| .| | ||.| .||  . .|   .|.||||..|   ...|.      ..||. | || | ...|  | 
fGsikvelvsleactggikrkltvl...kgdd.srtvtqfhfteWPd.kGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvv

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
   .  |.||||. |. .|...| .|   .|| | |.. ||.| 
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1250-1492 6.4e-52 171.3 In-house 39-278 (315) alignment 
Range on Protein: 1250-1492
Range on HMM: 39-278/315.0
ALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPE--N
|  . |..|||  .||| |.    |  ||    |.||||. . |...  |.| .| ||. .|.||||.||... |..||... .      | ||||.   
aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

GVHRHGPIQVEFVSADLEEDIISRIFriynAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeYNGGEGRTVVHCLNGGGRSGTFCAI
   . | |.|| .| .   | . | .      |  . .| | |||| .||  . ..    |.||||..|       .  |   .|||. | ||.| ...|
dsvefGsikvellsleadtdgvarkl....vtrkseesrtvtqfqftewPd.kGvdkqtssllklikevkad...ngkkefsllvhcsaGvGrtGvvisi

SIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
  | . ....|.||||. ||.||...| .|   ..| | |.. ||.| 
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN23_pd Subfamily PTPN23 947-1196 7.5e-52 170.9 In-house 42-279 (288) alignment 
Range on Protein: 947-1196
Range on HMM: 42-279/288.0
ENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTE
 .  |||. .|. |||.|| |.    ... ||||  .. .      ..||||.|.|.|. |||.||... .  |.|...  | |. |. .|||    .|.
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKS----KSPPSAGPLVVHCS
 ..|..||| ... . ..| |.. .|                  ..........  ..| ||..|||     || |. .|.|    .  .|  |||||||
kfgdlsvtlksvretethvervlklet.................ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCs

AGAGRTGCFIV-IDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
|| |||| | . . .. .. ...|..|| . |. ||  | .|||..||. |  .|.|||
aGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRB_pd Subfamily PTPRB 1222-1492 1.6e-50 166.8 In-house 21-286 (293) alignment 
Range on Protein: 1222-1492
Range on HMM: 21-286/293.0
QTNSSQIKEEFRTLNMVTptlRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDY
. .  ...||. .|. |    . . ...| |..|..|||  .||| |     | .... ..|.||||  .. |..|  ||.|| |||.||.||||.|.. 
adsdlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwek

HCTSVVMLNDVDP--AQLCPQYWPEN-GVHRHGPIQVEFVSADLEEDIISRIFRIYNaarpQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQ
... .||| ..     . | .|||..   . .| |.|..|. .  || . | ..| .    ..  | |.|..|. || . . | . ...|...|.|....
kssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdh.gvPektktlldfvrtvreai

EEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|. .  .. .||||  | ||.||| |.  . . .... .||.|  |  ||... ..|   .|| | ... |..|.
ekta.skrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0036282 (Phosphotyrosine protein) phosphatases II 976-1191 1.7e-49 163.2 In-house 2-164 (174) alignment 
Range on Protein: 976-1191
Range on HMM: 2-164/174.0
SDYINGNYIDGYHRPNHYIATQGPMQetiydFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDdteiykdikvtlietellaeyvirtfavekggagge
||||| ...|........||.|||..     ||.|.....  ...|.....| |..||. |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATgLLGFVRQVKSKSPP-SAGPLVVHCSAGAGRTGCFIVIDIMLDMAErEGVVDIYNCVRELRS
           .  .. |.. |.....|||||||  .. || ||..|..     . ||..|||||| ||||.......|| . . |..||... |||||.
...........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRl

RRVNMVQTEEQYVFIHD
 | .||||..|| |...
qrpgmvqtpsQyrflyy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1224-1493 3.7e-49 162.2 In-house 18-285 (290) alignment 
Range on Protein: 1224-1493
Range on HMM: 18-285/290.0
NSSQIKEEFRTLNMvtpTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGE---SSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDY
. .. ...| .|.    . . .   ..| . |...||  .|...|     |  | |.   . .||||. .. ||.  ..|.|| |..||..|||.|. . 
gnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

HCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPqDGYRMVQQFQFLGWPMYRDTPVSKRSfLKLIRQVDKwqE
..| .||| ..     . | ||||...... |..... ..    ...| | ... |     .  ..|.|.|.  |.   . .  . . | .|... |   
kvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqti.llvieemyk..t

EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
..  |..  |||| .. |||..|||. .  .  . .  .|||. .|..|  ||..|   .||.. ... |.||.|
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN12_pd Subfamily PTPN12 1223-1492 1.5e-48 160.2 In-house 5-278 (290) alignment 
Range on Protein: 1223-1492
Range on HMM: 5-278/290.0
TNSSQIKEEFRTLNMVTPTLRVED---CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVL
... . ..|| .| ...  .. |.    . .  ..| .|||  |||| |     | .|..|  |.|||| ..   ... ..| .| |||.|..||||.. 
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYHCTSVVML-NDVDPA-QLCPQYWPENGVHRH--GPIQVEFVSADLE-EDIISRIFRIYNAarpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQV
... . |||. . |. . . | .||||.| ..   |...|.  . .   .|.. | ... .     .  |.|.||..  ||  ...| |. | |.||..|
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPD.hgvPssaksllelielv

DKWQEeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 . ||     .   ||||  | || || .|| .| |.|.....   .|||. | .||.... .|   .||.. |.  .|...
relqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 947-1196 2.5e-46 153.1 In-house 40-276 (307) alignment 
Range on Protein: 947-1196
Range on HMM: 40-276/307.0
ENRMKNRYGNIIAYDHSRVRLQTiEGdTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDtEIYKD
 |  |||| .. . |..|. ... .|   ||||  ||.    .|...|..|||...|.|.|| |.  |.  |.||. ...|....|| .||| . |  | 
antdknryqdvkcqdkgrivvkf.dg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple.egqkl

IKVTLIETELLAEYVIRTFAVEKggaggeaNCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGC
. .   .|  .|.  ....| ..       ..    ..     .. | |... .. |||.|||    . . ..  |. .      |.||||||| ||.| 
vfgeapntisvanlgakklapde.......dlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....npvvvhcsaGvGrsGt

FIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
 . | .. | | . .   |. . |.||||.|   .||| ||...|  .|| 
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0046846 (Phosphotyrosine protein) phosphatases II 966-1194 7.6e-46 151.4 In-house 2-170 (176) alignment 
Range on Protein: 966-1194
Range on HMM: 2-170/176.0
RLQTIEGDTNSDYINGNYIDGYhrpnHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKdikvtlietellaeyvirtf
||. .  | ..||||.|.|.|.    ..||||||. .|..||..|.....   ....|..|| ||.||. |||. ..                       
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

avekggaggeancspsrevsqrgvheireirQFHFTGWPDHGVPYHaTGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDimldMAEREGVVDI
                               |.....||||||| . . || .......      || .|||||| ||||......    . |.|  ...
...............................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsv

YNCVRELRSRRV-NMVQTEEQYVFIHDAIL
.......|..|  ..|||.||| |.....|
eealalvreqRplgavqtpeQyrflyefel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1251-1491 1.6e-45 150.4 In-house 24-268 (274) alignment 
Range on Protein: 1251-1491
Range on HMM: 24-268/274.0
LLPRNHEKNRCMDILPPDRCLPFLITIDGE--SSNYINAALMDSYKQ-PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENG
 ......|||  .||| ..    | . ..|   |.||||  .  |..   |.. || ||||||.||||..   ... .||| ..  |.   | .|.|.. 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

VH----RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgyrmVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTF
      |.| ........  ..|   | . . .. |...    |. . .  ||  ...| . ...|.|...|.. .|| |   . .||||  | || | |
dyeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPd.hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 |||| .  ||.. .|||.. |  || ..  ||.  .||.. ...  .||
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN6_pd Subfamily PTPN6 1204-1492 1.8e-45 150.2 In-house 4-298 (306) alignment 
Range on Protein: 1204-1492
Range on HMM: 4-298/306.0
VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTpTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMD--SYKQPSAFIV
. |.....   ...| . ... . ..||| .|.    . .. . . .  |.|.||||   ||| |     |   .   |.||||  ..  . ..  ..| 
llakeieqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyia

TQHPLPNTVKDFWRLVLDYHCTSVVML-NDVDP-AQLCPQYWPENGV-HRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRD
||  |..||.||||.|.. ... .||. ..|.   . | .|||..   ...| |.|. || .  .| | | ... .  . ..  | | |..|  ||   .
tqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkke.erevfqyhfksWPd.hg

TPVSKRSFLKLIRQVDKWQEEYN-GGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQR---TVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
.| ..  .|.....|.. ||| .   .| .|||| .| || |||  | |. ......     .|. ..||..|. .  .|   .|||| |..  .|..
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0043147 (Phosphotyrosine protein) phosphatases II 973-1190 2e-45 149.9 In-house 2-154 (172) alignment 
Range on Protein: 973-1190
Range on HMM: 2-154/172.0
DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLvevgrvkcckywpddteiykdikvtlietellaeyvirtfavekgga
| .||||| .|.|.|. |...||||||...|. |||||.....   |...|.|                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

ggeancspsrevSQRGVHEIREIRQFHFTGWPDHGVPyHATGLLGFVRQVKS-KSPPSAGPLVVHCSAGAGRTGCFIVIDIMLdmaereG-VvDIYNCVR
               . .. |.. |.....||||||| ..  || |......     . || .|||||| ||||.......||        . .....|.
............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeava

ELRSRRVNMVQTEEQYVFIH
..|..| ..||...|| |..
lvrekRpgavqnpsqyrfly
0049772 (Phosphotyrosine protein) phosphatases II 942-1197 8.6e-45 149.1 In-house 40-280 (314) alignment 
Range on Protein: 942-1197
Range on HMM: 40-280/314.0
SAKKDENRMKNRYGNIIAYDhSRVRLQTIEGDTnSDYINGNYIDGYhrpNHYIATQGPMQETIYDF----------WRMV--WHENTASIIM--------
 |.. .|| |||| .|. .| .||.|.. .... ||||| .|.||.   . .||||||...|..||          ||||  .  |.  | |        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------VTNLVEVGrvkcCKYWPDDTEIYKdikvtlietellaeyvirtfavekggaggeancspsrEVSQRGVHEIREIRQFHFTGWPDHGV
              ..| . |    . ... | | .|                                     |.   . .  |.. ... . .||...
elsrLdaAlgKtpllildgng....neptaadlellk.....................................eelydpelferlgikylripvpDgsa

PyHATGLLGFVRQVKSKspPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAereGVvDIYNCVRELRSRRV-----NMVQTEEQYVFIHDAILEAC
|     .. |.. ...   .  ||..|||.|| ||||.|.|.....      || ..  .....|..|      ..... |||.||..|.||..
p.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1244-1490 1.9e-44 146.6 In-house 22-265 (283) alignment 
Range on Protein: 1244-1490
Range on HMM: 22-265/283.0
VEDCSIALLPRNHEKNRCMDILPPDRclpFLITIDGESSNYINAALMD---SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCP
  |. ||   .|..|||  .|.| |.   . . .. || .||||. .    ||||   .|..| || .||.|||..| | . |..|||  .  |  . | 
dldadiasadenkrknrnqeivpadq...wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRmVQQFQFLGWPMYRDTPVSKrSFLKLiRQVDKWQEEYNggEGRTVVHCLNGGGRS
||||..|   .|.  |       ..  | . . . . .  ..    .  .|. .|  | . ..   |..|.  .|   | | .  .|  |||| .|.||.
qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiin.slvkf.nkvislqtesk..kgPivvhCstgiGrt

GTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
..|.|.|   . .. .  ||||  || .|.... .|  |||||. .|..|| 
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 928-1195 2.7e-44 146.2 In-house 12-293 (297) alignment 
Range on Protein: 928-1195
Range on HMM: 12-293/297.0
EYESFF-EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTieGDTNSDYINGNYIDGY--HRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTN
|..... | ..  . |||..    |||| .|.|.| .||.|.   . |..|||| .|.     . . .|| .|||...|. |||..|....   |.||..
ekdllldeargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

LVEVGRVKCCKYWPDDTEiyKdikvTLIETELLAEYVIRTfavekggaGGEANCS--PSREVSQRgvHEIREIRQFHFTGWPDHGVP--------Y----
| | || ||  |||.  .  .     |  .... |.. .|          | .       ..  |   | | .|   | .|||||||        .    
lqedGrdkcapywpsvvq..e....rlkagdvvveflsst........sdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv

-----HATGLLGFVR--------QVKSK--SPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
         .|. |         |..|     |   .|.|||||| ||.|  .  |..|..  .. . |.   .. ||..|  .||| ||. ...||.|.
cscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0041856 (Phosphotyrosine protein) phosphatases II 1255-1492 3.8e-44 145.8 In-house 1-172 (182) alignment 
Range on Protein: 1255-1492
Range on HMM: 1-172/182.0
NHEKNRCMDILPPDRCLpflitidgeSSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNdvdpaqlCPQYWPengvhrhgpiqv
|..||| .||||.|. .          ..|||| |....  .. ||.||.||..|| ||.|.. ....|..|.|.       ...|||            
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp............

efvsadleediisrifriynaarpQDGYRMVQQFQFLGWPMYRDTPvsKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMlrhq
                        .. .|.. |...|.|| .  ..   ...|..|..| .        .|...|||  | ||.||..|. .....    
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....

rTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
  |....|||..|. .|.||  ..|| |.. ..||.| 
.gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1227-1492 2e-43 143.5 In-house 16-277 (281) alignment 
Range on Protein: 1227-1492
Range on HMM: 16-277/281.0
QIKEEFRTLNMVTptlrVEDCSIA-LLPRNHEKNRCMDILPPDRCLPFLIT-IDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
  .||...|. .     |.. . |   . | .||| ..|   |     .    . ....||||  ...||.. ..|.|| |.|.....||..|.... . 
Gfieeyeklaaig....vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

VVML-NDVDPAQL-CPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIynaARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEYN
.||. ....  .| | .|||..    . | ..|.....  ..  |.| |..    | .   | |.|.... ||     | . . .|.  ..| | .|. .
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPd.hGvPattkellefrkevlkltekkt

GgeGRTVVHCLNGGGRSGTFCAISIVCEML-RHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
      |.||  | ||.||. |.  ... . ......||   |. ||...  ||  . ||.| | . |..|.
k..aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_ptpA1_pd Subfamily ptpA1 924-1155 6e-43 142.1 In-house 22-254 (418) alignment 
Range on Protein: 924-1155
Range on HMM: 22-254/418.0
GFKEEYESFfEGQSAPWDS--AKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHrPNHYIATQGPMQETIYDFWRMVWHENTASIIM
  |||.  . |    | ..    |  |  |||| ||.  .|.||.|. |.    ||||| ||||| . |...|.||||. .|| ||||||| .    |.|
kikeefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivm

VTNLVEVGRVKCCKYWPDDTEIyKDIKVTLIETELLAEYVIRTFavekggaggEANCSPSREVSQR-----GVHEIREIRQFHFTGWPDHGVPYHATGLL
..   |  |.|| .|||..    ... .     |..  | .            |    | ||.  |        | |.| |... ||||| .| |.  . 
lsresencrikcdrywpeqigg.eqfsiygngnevfgtysvelv.........eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr

GFVRQV---KSKSPPS---AGPLVVHCSAGAGRTGCFIVIDIMLD
 ... .   . .  ||     |..|||||| |||| |    ||. 
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 946-1195 2.5e-42 139.5 In-house 52-281 (290) alignment 
Range on Protein: 946-1195
Range on HMM: 52-281/290.0
DENR--MKNRYGNIIAYDHSRVRLQtiEGdTNSDYINGNYIDGYHRPnhYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEi
|.|    |||| ...  | .|| |.  .|  . ||.  ||..| . .  .| |||....|. |.|||| .|..| |.|. .|.| |. || .|.|.    
dkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG.

ykdIKVTlietelLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEireIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGR
     .|      . |. .     ..  |    .    |.. .   |    .. ..   |||. |.  .  ||  .| ..  |    ||.||||||| ||
...evlt......fGeitvlcseeddkdaniikktlsvrdkdsGkehk...lkhlkikswpdksvalstlallrtlrilrkas....GpvvvhcsaGiGr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
|| |. |.. |..      .|. . || ||  |.| || . ||. . ...|.
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN23_pd Subfamily PTPN23 1224-1490 3.1e-42 139.4 In-house 13-279 (288) alignment 
Range on Protein: 1224-1490
Range on HMM: 13-279/288.0
NSSQIKEEFRTLNMVTPTLrVEDCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPS-AFIVTQHPLPNTVKDFWRLVLDYHC
. ......|. |..       .. |||.  .. ||||  |||| |.     ....|.  .||||. . .    .  ||.|| ||..|. |||..| . . 
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnR...vklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

TSVVMLNDVDP-AQ-LCPQYWPENG--VHRHGPIQVEFVSADLEEDIISRIFRIynAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDK-WQ
  .||| . .   .  . .||||.    ...|...|   |    |  . |....    ...|  ..|.  |.  || .   | |  ..|... .|.. ..
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkl..etldadavksvshlqltsWpel.GvPasPetllqfldevesaye

EEYNGGEGRTVVHCLNGGGRSGTFCAI-SIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
.. .  .   ||||. | ||.|.|. . ..| |. ...  .|. . |..||... .||   .|.||.||. ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 942-1197 6.9e-42 138.2 In-house 42-287 (305) alignment 
Range on Protein: 942-1197
Range on HMM: 42-287/305.0
SAKKDENRMKNRYGNIIAYDHSRVRLqtiEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT
. |. ... |||| ..   |. ||.|   ||    .||  ||.     |. .| || |...|  ||| | . ..  .|.|. ||.| |  ||..|.. . 
afkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

EIYKDIKvtliETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRqvksKSPPSAGPLVVHCSAGA
.   ...    | .      . . .  |  .  .|. . .  | .   .. | . ..|.  ||| |||   . .| ..     |. || ||.||||||| 
kdvlefe....ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpivvhcsagi

GRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||||  .... .||   . . . |    .. .| .| | .||..||.|.|. ||. .
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_PTPRN_pd Subfamily PTPRN 1224-1490 1.1e-41 137.5 In-house 27-291 (297) alignment 
Range on Protein: 1224-1490
Range on HMM: 27-291/297.0
NSSQIKEEFRTLNMVTPTLRVEdcSIALLPRNHEKNRCMDILPPDRCLPFL-ITIDGESSNYINAA-LMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYH
| .....|. .|       ...  ..|  ..| .|||  ..|| |     |  . . |.|.||||. ..|.  . .|.| || ||..|| |||..| .  
nkdrlekewealcayeaepstk..evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

CTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADL-EEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqe
.. .|.|  ..    . | .|||..| . ..  .|..||  .  .| . | | . |     .  | | || || ||  ...| | .|.|.. |.|.|   
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt..setrtvtqfhflswpe.egvPasaksllefrrkvnk...

EYNGGEGRTVVHCLNGGGRSGTFCAISIVCE-MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 | |     |||| .| ||.|....| .|.. .|.  . .|.  ... ||...|..|   ||..|.. .  | 
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN3_pd Subfamily PTPN3 1216-1488 2.6e-41 136.4 In-house 5-272 (280) alignment 
Range on Protein: 1216-1488
Range on HMM: 5-272/280.0
MNKLDPQTNSSQIKEEFRTLNMVTPTLRvedCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMD----SYKQPSAFIVTQHPLPNTVK
. .|  . .| ..  .| .|    | |    .|.| .|.| .|||  |||| |      .... ....||||  ..    | ..   .|.|| ||..|..
llllkeglesGavlaqfeqlyrkkpgla...isaarkpenlsknryrdilpydatr...vklkesetdyinanyvnmeipstglvnryiatqGPlaktat

DFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENG-VHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMyRDTPVSKRSFLK
|||..| . ... .||| ..     . | |||||..   ..| ..|.  . | .. .. | . . ...   .  |.. |.|.| ||   . | .. .||.
dfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket..keerkilqlqylaWpd.hgvPddsadfle

LIRQVDKWQeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL
....| | .   .| |  .||||  | ||.| . .. .   .. ... | . . |.|.|. . ..|.  .||||  |  |
fvervrklr...sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0049260 (Phosphotyrosine protein) phosphatases II 983-1191 3.7e-41 135.7 In-house 1-144 (152) alignment 
Range on Protein: 983-1191
Range on HMM: 1-144/152.0
YIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWpddteiykdikvtlietellaeyvirtfavekggaggeancspsr
.||||..|...||||||. .|. |||||... .   |.|.|.|.| |..|| .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

evsqrgvheireirQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLdmaereGVVDIYNCVRELRSRRVNMVQT
              |.... ||||||| ..  || ... ..     . || .|||||| ||||.......||        |.....|. .|..| ..|..
..............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn

EEQYVFIHD
..|. |...
pgqlrflye
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 947-1194 6e-41 135.0 In-house 51-287 (310) alignment 
Range on Protein: 947-1194
Range on HMM: 51-287/310.0
ENRMKNRYGNIIAYDHSRVRLqTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD--DTEIY
..  |||| ...  | |||.| .|.     |||  ||.   .  . .| .|||.| || |||||.. | . ||... . .| || ||  |||    || |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

KDIKVTLIeTELLAEYVIRTFAVEKGGaggeaNCSPSREVSqRGVHEIReIRQFHFTGWPDHGVPYHATGLLG--FVRQVKsksppsAGPLVVHCSAGAG
  |.|| . .|   |. |  .||         .  |  |     ..|.| .   ..  ||| |||      .   .. ||.       || ||||||| .
gcirvtnl.sesseefeicnlavtfvp.....dnvpvdeqp.anlkelr.vslikwpnwpdrgvpdekchtvpqrllaqvr......hgpcvvhcsagkd

RTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
|... . ... .| ..|   ||. . . ||. .|.  .||| ||..|.   .
rlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1222-1492 3.4e-40 132.6 In-house 11-294 (301) alignment 
Range on Protein: 1222-1492
Range on HMM: 11-294/301.0
QTNSSQIKEEFRTLNMVTPtlrvEDCSIALLPRNHEKNRCMDILPPDRC---LPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVL
...| ...|....|. ...    . |.. |  .|.. ||  .| . |     |    ..|  . .||||  .|.|..  .||..| |. .|..|||||..
akhsnkfeeqykelkeged....ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

DYHCTSVVMLNDVDPA--QLCPQYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFR--IY------------NAARPQdGYRMVQQFQFLGWPmyRDTP
... .|.||. . .    . | ||||.     .. ||..|..|.     | . | .   |.            .  . .   . | |.|   ||   |  
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWp..qdGv

V-SKRSFLKLIRQVDKWQEEYngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
|  .|  |. | .| . |     | |  |||| .. .|||..|..||  |  . .  ||||  .|..| .|| .|  |.|| . |.|  .||.
vreprtvLqviddvihrqqki..gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0049772 (Phosphotyrosine protein) phosphatases II 1213-1492 3.7e-40 134.0 In-house 3-281 (314) alignment 
Range on Protein: 1213-1492
Range on HMM: 3-281/314.0
YYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVED-CSIALLPRNHEKNRCMDILPPDrCLPFLITIDGESSNYINAALMDSYkqpSAFIVTQHPLPNTVK
.|...... ....... ... .||...... .|  . .| |..|..|||..|||| | .. .| . ....|.||||  .|..    .||.||.||..|| 
ayplasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvv

DF----------WRLVL--DYHCTSVVM---------------------LNDVDPAQlcPQYWPENGVHRHgpiqvefvsadleediisrifriynaAR-
||          ||.||  |...  .||                     |...|. .  .......  . .                           . 
dfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk..........................eel

-----PqdgYRMVQQFQFLGWPMyRDTPvSKRSFLKLIRQVDKWqeeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLrhqrTVDVFHAVKTLRNNKP-
     .    |.. ..  . .|   ..| . . |..... ....       .|...|||  | ||.|||... ...  |     |..  |.. .|.  | 
ydpelf...erlgikylripvpD.gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpi

----NMVDLLDQYKFCYEVALEYLN
    ...  |.|| |..|. ||||.
npnpgfieqleqyefilealleylk
subfamily_PTPN13_pd Subfamily PTPN13 1219-1492 4.6e-40 132.6 In-house 4-270 (273) alignment 
Range on Protein: 1219-1492
Range on HMM: 4-270/273.0
LDPQTNSSQIKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLpflITIDGESSnYINAALMDS--YKQPSAFIVTQHPLPNTVKDFWRL
|  . .. | .|||..|. . |.   ..|...   .|..|||  ..|| |.     .....|.. ||||.|.     |.   .|..| |||.||||||..
lqkkldqqqPaeefkelrelkpl...dtcevgkkkenkdknryrnvlPydetr...vklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VLDYHCTSVVML-NDVDPAQL-CPQYWPENG---VHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIR
| . ... ..|. ....  .. | .||||.    .  .. ..|| .     ..   | . . . .      | |....|  || . ..| |  ..|....
vweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..gesrevahlnfvkwPdh.gvPssaaellqfva

QVDKWQEeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
.| . |.     .|  ||||  | |||||. .| .| ... ... .|| . |..||. .  .|   ||| |.|...|| |.
evrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
MAM MAM domain 27-183 1.8e-39 123.4 Pfam-A 1-159 (160) alignment 
Range on Protein: 27-183
Range on HMM: 1-159/160.0
CLFDEPysTCGYSQSEGDDFNWEQVNTLTK-PTSDPWMPS------GSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNsppGLLNVYVK
| |.|   .||.||.| ||..|..|.. |. ... |...       |..|.|..| ..||..|.||.|.|......|..|.|..|....   | |||||.
CdFeee..lCgwsqdetddldWtrvsgstptektgpssdhtlgkesghymyvetssgaegesarllspllpasssaClrFyyhmsgsev...gtLnvyvr

VNNGPLGNPIWNISGDPTRTWNRAELAISTFwPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCT
 ....  ...|.|||. ...|..||...|.. .. .||.||..  .|..|..|.|....  ..|.
eekegeetllweisgnqgssWqeaevtlsai.tkkfqvvfeavrgkgsegdialDdislsegeCs
0036282 (Phosphotyrosine protein) phosphatases II 1282-1485 2.1e-39 130.4 In-house 2-164 (174) alignment 
Range on Protein: 1282-1485
Range on HMM: 2-164/174.0
SNYINAALMDSYKQPSAFIVTQHPLPntvkdFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPEngvhrhgpiqvefvsadleediisrifriynaaRPQ
|.||||  .| .  .. .|..|.||.     ||... ....|.||||..  . .  .|..||||                                 ...
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DGYRMVQQFQFLGWPMYRDTPVSKrsFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRhQRTVDVFHAVKTLRNNKPNMVDLLDQ
| .|.. |...|.|| .   ..|.  .|.....|.....|  ...| ..|||  | ||.||..|. ... .|. ...||... |..||. .|.||   .|
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFCYE
|.|.|.
yrflyy
0051429 (Phosphotyrosine protein) phosphatases II 1281-1492 6e-39 129.7 In-house 3-226 (272) alignment 
Range on Protein: 1281-1492
Range on HMM: 3-226/272.0
SSNYINAALMDSYKQ---PSAFIVTQHPLPNTVKDFWRLvLDYHCTSVVMLNDVD--PAQLCPQYWP------------ENGVHRHGPIQVEFVSADLEE
 |.||||  .. | .   | ... ...|||.|..|||||  .......|.| ...  ... |..|||            .   ...| . | ..|  | .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DIISRIFRIYNAARPQDGyRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQvdkwqeeynggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVD-----
|.| | .....   .... |.| ......|| .   . . ...|.|...           .|. .|||  | .|.||..|. .. . . ..  ||     
dyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
   ...||. ||   |..|   .||.|.||..||.|.
nlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 945-1195 3.5e-38 125.9 In-house 34-267 (281) alignment 
Range on Protein: 945-1195
Range on HMM: 34-267/281.0
KDENRMKNRYGNIIAYDHSRVRLQT-IEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI
.  |  |||| || . | |||.|.  .     .|||  |||        || |||| .||  |||||.|.|||..|.|. ...|  | ||..|.| ..  
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

YKDIkvtlieTELLAEYVIRTfaVEKGGAGGEANCSpsrevsQRGvhEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSagplVVHCSAGAGR
  ..       .|  .|   |  |.|       | |        |  | | | .. .  |||  ||  .  .|  .|.....| |     |.||||| ||
clqf......dklsvsyedst..vnkslvttrlnls......yeg..etrlithwlwkewpdwqvpessevmlkilrkirarstpp....vihcsagvgr

TGCFIVIDIMLDMAE-REGVVDIYNCVRELRS-RRVNMVQTEEQYVFIHDAILE
.| .. ..| |.    .  . || . |  ||   |   ||| .||..|   .|.
sgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_PTPN14_pd Subfamily PTPN14 1218-1493 4.4e-38 126.0 In-house 15-298 (300) alignment 
Range on Protein: 1218-1493
Range on HMM: 15-298/300.0
KLDPQTNSSQIKEEFRTlnmVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSY--KQPSAFIVTQHPLPNTVKDFWR
 |. . .....  |.     ...     ..| | || | ||||  |.|| . .   |..   .|..||||. .      .   .||.| ||..||.|||.
ilekkleegkvfteyer...ipkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWq

LVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVH----RHGPIQVEFVSADLEEDIISRIFRIYNAarPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKL
.| . . . .||| .   |  . . .|.|... .    ..|  .|     .  . .| . ....    |   .| |  .|.  ||  .. |   ..||. 
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl..pskeertvwhlqytDWpd.hgvPeDvkgflsy

IRQVDKWQEEYNGGE------GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
...|.  ... |            .|||..|.||.|      .. . | |....|. .....||. .  .|. | |||| |.| ..||..
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0044763 (Phosphotyrosine protein) phosphatases II 960-1195 5.2e-38 125.8 In-house 2-169 (178) alignment 
Range on Protein: 960-1195
Range on HMM: 2-169/178.0
YDHSRVRLQTIEGDTNSDYINGNYIDGYhrpnHYIATQGPmqetiYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiykdikvtlietellae
.|..|| |...||   ||||| ..|...     |.....|      |...... ..  .|...|. .| |..||..|||....                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yvirtfavekggaggeancspsrevsqrgvheireiRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMaer
                                     |......||||||     .| ||. ...  ... || .|||||| ||.|.......|. .   
....................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...

eGVvDIYNCVRELRSRRVnMVQTEEQYVFIHDAILE
 |. .........|.||  .|....|. ....  |.
.gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
0051082 (Phosphotyrosine protein) phosphatases II 976-1194 2.7e-37 123.0 In-house 3-150 (151) alignment 
Range on Protein: 976-1194
Range on HMM: 3-150/151.0
SDYINGNYIDGYhrpnhYIATQGPMQetiyDFWRMVWHENTASIIMVTNLVEVGrvKCCKYWPDDTeiykdikvtlietellaeyvirtfavekggagge
||||| .|..|.     .....||..    ||........  .|.......| |  .| .|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ancspsrevsqrgvheiREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSkspPSAGPLVVHCSAGAGRTGCFIVIDIMLDMaeregvVDIYNCVRELRSR
                 .|........|||.|.| .   .| |.... .   .. ||..|||||| ||||.......|| .      |... ...|.|..
.................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlk

RVNMVQTEEQYVFIHDAIL
| ..||...|..|.. |.|
rpgvvqpnqqflfqlfall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 945-1196 2.8e-37 123.0 In-house 52-288 (305) alignment 
Range on Protein: 945-1196
Range on HMM: 52-288/305.0
KDENRMKNRYGNIIAYDHSRVRLQTIEgdtNSDYINGNYIDGYHRPN-HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI
 | .  |||| .. . |.| |.|.       ||||  ||.     |.  .|..|||...|| .|| || ...   |.|. . ||.|..||..|||     
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

YKDIKVTlieteLLAEYVIRTFAVEKGgagGEANCSpSREVSQRGVHEIrEIRQFHFTGWPDHGVPYHATGLLGFVRQVKSksppSAGPLVVHCSAGAGR
 ...|       .. | |  .  .|.     | . .   ...  | ...  .|....| ||| |||      | ..  ..     |  |.||||||| ||
klelksg.....ivvenvsgskpmerd...aeiqit.llnltysgdqkm.svrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigr

TGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
||  . |. .|. .||   .  . . |. || .|   .|.. ||.|||  .|. 
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1248-1492 3.8e-37 122.7 In-house 13-265 (270) alignment 
Range on Protein: 1248-1492
Range on HMM: 13-265/270.0
SIALLPRNHEKNRCMDILPPDRCLPFLITIDGE-SSNYINAALMD-SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPE
..    |... || .||||  .    | ... .  ..||||  .    ... ..| .. |||.|.|.|||.... . |..||. ..     . | .|||.
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

NGV----HRHGPIQVEFVSADLEEDIISRIFRIYNAArpqDGYRMVqQFQFLGWP-----MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEgRTVVHCLNG
.       ..| |.|  .|   ||  | .  |. . .   .  |.|  |..  ||        |. .| .. ||..|.| ....| . .|  ..||| .|
epkekvkledgkikvlalseekeegyiltrlrleekg...eerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaG

GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
 ||.||. |. |....| ... ||| . .. ||......|.  .||.| |.. .|| .
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0046846 (Phosphotyrosine protein) phosphatases II 1272-1492 5.9e-37 122.5 In-house 2-174 (176) alignment 
Range on Protein: 1272-1492
Range on HMM: 2-174/176.0
PFLITIDGESSNYINAALMDSYKqpsaFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLC--PQYWPEngVHRHGPiqvefvsadleediisri
............|||| |.....    .|.||.|||.|. ||.........| ||.|..    . .  |.||||  ....|                   
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

friynaarpqdgyrmvqQFQFLGWPMYrDTPVSkRSFLKLIRQVDKWQEEYnggeGRTVVHCLNGGGRSGTFCAisivCEMLRHQRTVDVFHAVKTLRNN
                 |...|.|| . ..| . . .|.|.........|     |...|||  | ||.||..|    . .|.... ..|..|....|. 
.................qylhlpwpDh.gvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreq

KP-NMVDLLDQYKFCYEVALEYLN
.| ..|   .||.|.||..|..|.
RplgavqtpeQyrflyefellllk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1218-1492 8.4e-37 121.6 In-house 13-280 (439) alignment 
Range on Protein: 1218-1492
Range on HMM: 13-280/439.0
KLDpQTNSSQIKEEFRTLNMVTPTLRVeDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRL
||| . .   .||.| ..| . |  .. ..|.|    .. |||  |. . |     |  | |   | ||||  .. | ..  .| || |  .|..|||||
kld.knkqeifkeifekinstspdyac.iaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrl

VLDYHCTSVVMLNDVDPAQLcpqYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKW
|.. ... .||| ..  .     ||| ..   .| | |         . . | |...|     .  | | ||... ||  .. |      |...| ..  
viekktvtivmltnlvesyk...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpd.knvpaqashvldflrainsa

QEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
... .   |  ||||  | ||.||  |. |  | |. .  ||.   || ||... .||. | || | |.  || . 
ndkee..ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1255-1490 1.1e-36 121.1 In-house 38-276 (287) alignment 
Range on Protein: 1255-1490
Range on HMM: 38-276/287.0
NHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVML-NDVDPAQL-CPQYWPENGVH-RHGP
. .|||  |.|| |    .| .     |.||||  . ||..  |||..| |.. ||.||||.||. . .||...  .|. |.| | .||||. |  | | 
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

IQVEFVSAD-LEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRDTPVSkRSFLKLIRQVDKWQEEYN--GGEGRTVVHCLNGGGRSGTFCAISIVC
  |  .. | .| .   | .|. ..       |.|.|...| ||    .| .  ...... .| .  |      . |  |||.  | ||||.. |. .. 
ysvvlldydikePeygvralrlidlet..rearvvkqldllswPdkvlaPta.vglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
..|     |||  .|  ||. .  .|    |... ||    |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 949-1194 4e-36 119.4 In-house 48-341 (350) alignment 
Range on Protein: 949-1194
Range on HMM: 48-341/350.0
RMKNRYGNIIAYDHSRVRLQ-------T-IEGDTNSDYINGNYIDGY-----HRPNH-YIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC
  |||| ||. |.||||.|.       .       .|||| ||.          |.. |||||.|...|. ||.... . .   |...|..|| .. || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPDDTEIYKDIKVTLIE--TELLAEYVIRTFAVEKGGAgGEANCSPSREVSQ--------RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVR----
.||.. .   . .|..     .    . ..... |.|  .  . | |   .. .          . .  .. |...  |.| .. ..   .|  .     
rYWqegsydditvklaskwenimgindsslysadvkkeas.dndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

---QVKSK---SPPSAGPLVVHCSAGAGRTGCFIVIDIMLD-------MAEREGVVD--------IYNCVRELRSRRVNMVQTEEQYVFIHDAIL
   .  ..       . |..|||||| |||| .. .| .|        . ..   .|        |   | |||..|..|||. .|..||..|.|
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_PTPN1_pd Subfamily PTPN1 1247-1489 4.1e-36 119.2 In-house 24-269 (290) alignment 
Range on Protein: 1247-1489
Range on HMM: 24-269/290.0
CSIALLPRNHEKNRCMDILPPDRClpfLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN
.. | ||.|...||  |. | | .    |... .. .||||.|..  .    .|.|| ||||||. ||..| . .. .||||| |     . | ||||..
treaklpenrnlnryrdvspydhs...rikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

G-----VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQdgYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKwQEEYNGGEGRTVVHCLNGGGRSG
      .  .  ..|...| . ..  . |.... |    .   | . .| .. || .   | |  .|||.. .| .     .   | .|.||  | ||||
eeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdf.gvpespaaflkflfkvre.sGslssdvGpavihcsaGiGrsG

TFCAISIV-CEMLRHQ--RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
||| .  .  .. ...   .||. . .  ||. .  ..   || .| |   ||
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
PTPc_DSPc_SM00012 1095-1195 4.3e-36 118.7 In-house 2-105 (105) alignment 
Range on Protein: 1095-1195
Range on HMM: 2-105/105.0
IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSA--GPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHD
....|.||||||||| ... .| ..|.||..   |.  .|.|||||||.||||.|...||.|.. |.| . |||...|.|||..| .||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
0043147 (Phosphotyrosine protein) phosphatases II 1280-1485 1.9e-35 117.5 In-house 3-155 (172) alignment 
Range on Protein: 1280-1485
Range on HMM: 3-155/172.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVdpaqlcpqywpengvhrhgpiqvefvsadleediisrifriynAARPQ
|.|.|||| ..| |  |  ||.|| ||.||. ||||.. ....| .|.|..                                               |.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DGYRMVQQFQFLGWPMYRDTpvSKRSFLKLIRQVDKWQeeYNGGEGRTVVHCLNGGGRSGTFCAISIVCemlrhqRTVDVFHAVKTLRNNKPNMVDLLDQ
. .|.. |...|.|| .  .  . . .|......|...   .  .|...|||  | ||.||..|. ...      . .....||...|. .|..|   .|
llerlgiqylylpwpDhgvp..llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YKFCYE
|.|.|.
yrflyy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 947-1196 6.5e-34 112.3 In-house 42-270 (288) alignment 
Range on Protein: 947-1196
Range on HMM: 42-270/288.0
ENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKD
.|  ..|| |.   | .||.|.    |    ||. | .   . ... | .| |.. ||  .|.|. ...   |.|...|.| |. |  .|.|        
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

IKVTlietellaeyvirTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGC
|.                  | |  |. .   . |    .. ..|   ... |.  |.|.|||      | ..  .||       |.|||.|||.|||| 
igrl.............ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgt

FIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.|.| |.|...  .  . | . . .||  | . .||| ||...|  .|| 
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1091-1234 1.6e-32 107.4 In-house 87-231 (440) alignment 
Range on Protein: 1091-1234
Range on HMM: 87-231/440.0
EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK-SKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI
| | ..|.|. ||||.|||  |  .| ....|. |.   . |||.|||||||||||  |..| .|  |.|   .||.. .  .|. | .|||| |||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRT
|.|.||. ||||| .   ..     ...  .|.|. | ...||  
heavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1225-1490 1.5e-30 101.1 In-house 5-258 (267) alignment 
Range on Protein: 1225-1490
Range on HMM: 5-258/267.0
SSQIKEEFRTLNMVTPTLRVEDCSIALlpRNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
  .|..||  .. ...|     .|||    |.|.||  | || |      . .  .  .||||. ...||.  |||||| || ||. ||. .. |.... 
eceiekefelikkisdtsstisqsiae..knqernrlddnlpyddtr...vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

VVMLNDVDPAQLcPQYWPEN--GVHRHGPIQVEFVSADLEEDIisRIFRIYNAARpQDGYRMVQQFQFLGWPMYRDtpvsKRSFLKLIRQ-VDKWQEEyN
.|.|  |   .. ...|| .    ...  . ||.     |.|   .|  .    . ..  . |  . .  | .  .    .. .|| .   . | | | |
ivlltkvftdni.rlfwPPkmgqakkyqdltvehslekeendy..qiitlelkfk.nesahnvtlyyykkwnintn....nkpylkplfgilaknqle.n

gGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 |.   ||.| .| ||||||  |    | .... ..|.|. .. .|. .. .|| ...| ...|.  ||
.gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049260 (Phosphotyrosine protein) phosphatases II 1290-1485 1.7e-30 101.1 In-house 2-144 (152) alignment 
Range on Protein: 1290-1485
Range on HMM: 2-144/152.0
MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWpengvhrhgpiqvefvsadleediisrifriynaarpqdgyrmvqq
.| |..| .|| ||.|.|||..||||.. ....| .|||.. ..     |.||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

fQFLGWPMYRDTPVSKRSFLKLIRQVDKWQeeYNGGEGRTVVHCLNGGGRSGTFCAISIVCemlrhqRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE
 |.| .|.  ... .   .|. . .....   .   .|...|||  | ||.||..|. ...      . |....||. .|. .|..|   .|..|.||
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 951-1196 6.8e-30 98.8 In-house 46-275 (312) alignment 
Range on Protein: 951-1196
Range on HMM: 46-275/312.0
KNRYGNIIAYDHSRVrlqTIEGDTNSdYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiYkdikVT
 ||| ||  .|  |    |. || |  ||  |..    .|.....||||...|.  ||...    ..|||... .|| |  ||.||  |    .    | 
lnrypniqcwdrgrf...tlagdenf.yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.f....vd

LIETELLAEYvirTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGCFIVI
| .  . .||      .| ||   .        |  .   .   . .. .. |||||.|      | ..  ||        |.. ||||| |||| ...|
ledhrvytey...cteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlali

DIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
. |.         .. .    ||  |   |..  |||.   ..|| 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 946-1197 1.9e-29 97.5 In-house 33-270 (285) alignment 
Range on Protein: 946-1197
Range on HMM: 33-270/285.0
DENRMKNRYGNIIAYDHSRVRLQtiegDTNSDYINGNYIDGYHR-PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEI
. |   ||| .. . . .|| |.    . . |||  ...    .  . ||.||||. ||. |||.|...|. | ..|.  |.| |  ||. |.|.   |.
eanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

YKDIKVTLIETELLAEYVIRTFAVEKGGAGGEancspsrevsqRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKsKSPPSAGPLVVHCSAGAGR
 |  |  .  ||   | .  |          |               |   . . .   |||.  |  |  .. . . || |  |   |..|||||| ||
vkfgkyeitlteckeeaiagtilnaltvinte...........dasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvgr

TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
|  |. ||        .  ... . |||.|. |.. ||.  |..|..  ..|  
tatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0051082 (Phosphotyrosine protein) phosphatases II 1281-1487 3.2e-28 93.6 In-house 2-149 (151) alignment 
Range on Protein: 1281-1487
Range on HMM: 2-149/151.0
SSNYINAALMDSYkqpsaFIVTQHPLPntvkDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGvhrhgpiqvefvsadleediisrifriynaarpqd
 |.|||.  ....     ......||.    ||..|. .......|.|.. .. . ||.|.||.|                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

gyRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKwqeeynGGEGRTVVHCLNGGGRSGTFCAISIVCEMlrhqrtVDVFHAVKTLRNNKPNMVDLLDQY
  . | ....|.|| . ..|.|  ..|........       ..| ..|||  | ||.||..|. .....      |... |.. .|   |..|   .|.
..ievlhipildwpdp.glplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

KFCYEVA
 |.. . 
lfqlfal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1255-1489 1.2e-27 91.6 In-house 7-238 (239) alignment 
Range on Protein: 1255-1489
Range on HMM: 7-238/239.0
NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENgVHRHG
|. |||  .|.  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||.. . .   .|||  .     . | ||||..   .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEM
 ..| .  ...  | | | | . .    |   | | |..|  ||  .  |    . | | |.. |   .   |    |.||  | ||.|.|  |  .   
nlrvtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpd.kgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
 ..|.|||.|  ||..|...| ||.  .|| | .   ||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1255-1488 1.5e-27 91.3 In-house 8-238 (239) alignment 
Range on Protein: 1255-1488
Range on HMM: 8-238/239.0
NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPENgVHRHG
|. |||  .|.  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||.. . .   .|||  .     . | ||||..   .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVEFVSADLEEDIISRIFRIYNAArpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEM
 ..| .  ...  | | | | . .    |   | | |..|  ||  .  |    . | | |.. |   .   |    |.||  | ||.|.|  |  .   
nlrvtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpd.kgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

LRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL
 ..|.|||.|  ||..|...| ||.  .|| | .   |
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 978-1188 2e-27 90.8 In-house 77-272 (301) alignment 
Range on Protein: 978-1188
Range on HMM: 77-272/301.0
YINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEiyKDIKVTLIETELLAEYVIRTFAVEKGgaggean
 |  |.|.   .|...||||||...| .||| |. . .   |.|... ||    || .| | ...  .....   . ..  . .|    . |        
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknkelilnkkiskr.......

csPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSksppSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV
    . .   |  . | .  . .. |.|.|||   . |  ..  ||     |  |.||||||| ||. .||  ...    | .  ... . ...|| .| 
..tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrw

NMVQTEEQYVF
| |||..|  .
ngvqtnsqlyw
subfamily_ptpA1_pd Subfamily ptpA1 1226-1453 3.9e-27 90.0 In-house 21-258 (418) alignment 
Range on Protein: 1226-1453
Range on HMM: 21-258/418.0
SQIKEEFRTLNM-VTPTlrveDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSyKQPSAFIVTQHPLPNTVKDFWRLVLDYHCT
 .|||||| |.  | |.    . |     .|  |||  .||| ..    |  | | | |.||||  .|    |  ||.|| |||||. ||||.| . .| 
hkikeefrlleesvgps....etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcr

SVVMLNDV-D-PAQLCPQYWPE-----------NGVHRHGPIQVEFVS--ADLEEDIISRIFRIYNAARpqdgYRMVQQFQFLGWPMYrDTPVSKRSFLK
 .|||.   .     | .||||           ||    |   ||.|    | | .||.|  |.          | . |.|. ||| . . |   . | .
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege....trditqyqyegwpdh.nipdhtqpfrq

LIRQVDKWQEEYNGGEGRT---VVHCLNGGGRSGTFCAISIVCEMLRH
|.. . . |..      |    .|||  | ||.||||.  |. . | |
llhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1254-1489 9.8e-27 88.7 In-house 2-237 (237) alignment 
Range on Protein: 1254-1489
Range on HMM: 2-237/237.0
RNHEKNRCMDILPPDRCLPfLITIDGESSNYINAALMDSYK-QPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPEN-GVHRH
.|. |||  .|   | .   ..   | .|.||||. ....   |  .| .| || .. .|||..| . .|. .|||  .     . | .|||.      .
enkiknrygnivaydhsrv.vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPIQVEFVSADLEEDIISRIFRIYNAARpQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCE
| . | .   .   |   | . . .  . . . |...|.||  ||  |  |    ..|.. ... . . ..    |  ..||  | ||.| |  |  .  
gvltvslkkkeefsdytvrslllskrlt.lkevrlihqyqftswpd.rgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlr

MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE
  . .. ||..  |... ...| ...  ||| | ... ||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
PTPc_DSPc_SM00012 1385-1489 1.7e-26 87.8 In-house 2-105 (105) alignment 
Range on Protein: 1385-1489
Range on HMM: 2-105/105.0
VQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ-RTVDVFHAVKTLRNNKPNMVDLLDQYKFC
|......|||    .| .  |.|.|.|.|.|.... .  .. .|||| .| ||.|||.|..|....|... ..||.|  || ||. .|.||. ..|| |.
vkhyhytgwpdh.gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YEVALE
|.. ||
yralle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1226-1491 5.7e-26 86.2 In-house 16-277 (307) alignment 
Range on Protein: 1226-1491
Range on HMM: 16-277/307.0
SQIKEEFRTLNMVTPT-LRVEdcsiaLLPRNHEKNRCMDILPPDRClPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTS
.....||| |   ||  . ||      .  | .|||  |.   |..   ....|| .|.|| |  .    .|  ||..| || ||. .|| .... .  |
qalvdefrvlakktpegvtve.....afsantdknryqdvkcqdkg.rivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

VVMLNDV-DPAQL-CPQYWPEN-GVHR-HGPIQVEFVSADLEEDIISRIFRIYNAA----RPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkw
|.|| .| . |.. | |||| . | .  .|        |.|  . ..    . | .       .. | .|..|.  ||  | .|  . . . |.  |   
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd.rgvpqinltainlleav...

qeeyNGGEGRTVVHCLNGGGRSGTFCAISIVC-EMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
    .. .   ||||  | |||||  |||.|   |.. .   |. . |. ||....  .    || . . | |||.
....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1229-1490 2.1e-25 84.0 In-house 30-282 (290) alignment 
Range on Protein: 1229-1490
Range on HMM: 30-282/290.0
KEEFrtLNMVTPTLRVEDCSIALLPRNH--EKNRCMDILPPDRCLpfLITIDGESSNYINAALMDSYKQPsaFIVTQHPLPNTVKDFWRLVLDYHCTSVV
  |.  |. . | | |.     .. .|   .|||  |.   |.    .|  ||   .|. |  ..  | .  ||.|| .| .|| |.||.||. . . .|
akey..leklkpylpvqylerkifdkntefkknrykdvvcndktr..vilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaiv

MLNDV--DPAQLCPQYWPENG--VHRHGPIQVEFV-SADLEEDIISRIFRIYNAARPQDgyRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeyn
|| ..  |    | ||.||.   |   | | |    . | ...|| ... . .    ..   ... ..   ||  .  . |. ..|...| . |      
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke..hklkhlkikswpd.ksvalstlallrtlrilrka.....

ggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
   |  ||||  | ||.||| || .  ..| . . .|.   |..||| . | |..  ||    |. |..
..sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_egg_pd Subfamily egg 938-1194 2.2e-25 84.0 In-house 30-267 (307) alignment 
Range on Protein: 938-1194
Range on HMM: 30-267/307.0
APWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVgrVKCCKYW
 .   | .|.|. | |   .   | |||.|.  .|    |.|  |...|    |..| .| |...|  ||||||. |.   |.|.|  .|    .|  ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PDDTE---IY--KDIKVTLIETELLAEYVIRTFAVEKggAGGEancspsrevsqrgvHEIREIRQFHfTGWPDHGVPYHATGLLGFVRQVkskSPpsagP
|   .   ..    .... .. .  |. . |   .     ||.              .| | .  .    .   .  |    .|  .|..   |     |
pkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd..............deerflehwq.gdvnnssdvysplrvlrklrnl...sk....p

LVVHCSAGAGRTGCFIVIDIMLDMAEREGVV--DIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
 ||..  |  ...... |.| |    |  ..   . ..|  || ||   |..  .|.|..  .|
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0044763 (Phosphotyrosine protein) phosphatases II 1279-1492 4.4e-25 83.8 In-house 15-172 (178) alignment 
Range on Protein: 1279-1492
Range on HMM: 15-172/178.0
GESSNYINAALMDSYkqpsaFIVTQHPLpntvKDFWRLVLDYHCTSVVMLNDVDP---AQlCPQYWPEN-Gvhrhgpiqvefvsadleediisrifriyn
 |.| ||||  .. .     ......|      |...|. ....|..|.|.. ..    . |..||||. |                             
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflk.cdpywpeeag.............................

aarpqdgyrmvqqFQFLGWPMYRDTPVS-KRSFLKLIRQVDKWQEEYNggeGRTVVHCLNGGGRSGTFCAISIVCEMlrhqrTVDVFHAVKTLRNNKPnM
             .|.| .|.  ... .  . ||.... ......| .   |...|||  | |||||..|. .....      .....|.. .|. .| .
.............iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

VDLLDQYKFCYEVALEYLN
|   .|....||..|..|.
vpnpgqlrqLyefelrllk
0048076 (Phosphotyrosine protein) phosphatases II 1091-1194 5.2e-25 83.2 In-house 43-140 (145) alignment 
Range on Protein: 1091-1194
Range on HMM: 43-140/145.0
EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDIMLDmaerEGvVDIYNCVRELRSRRVNMVQTEEQYVFIH
. |.. |.....|||||||  .  || |......  .   || .|||||| ||||.......||     .| |.........||.| ..|....|. |..
lerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrfly

DAIL
...|
efel
0048179 (Phosphotyrosine protein) phosphatases II 1090-1191 7.8e-25 82.7 In-house 44-139 (144) alignment 
Range on Protein: 1090-1191
Range on HMM: 44-139/144.0
HEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSaGPLVVHCSAGAGRTGCFIVIDIMLdmaeREGvVDIYNCVRELRSRRVNMVQTEEQYVFI
...||. |.....||||||| ... || |.. ...  ... || .|||||| ||||.......|.    ..| ..........|||| ..|....|. |.
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

HD
..
le
subfamily_CG42327_pd Subfamily CG42327 949-1124 3.2e-24 80.2 In-house 29-192 (319) alignment 
Range on Protein: 949-1124
Range on HMM: 29-192/319.0
RMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYH-RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP-----DDTE
. |.|. |..   ..|| || |  | .. |.. .|. ||.  ||.|||.| .....  ||||.||  ..  |. .|.| | |  .| .|.|     |.|.
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

IYKDIKVTLIETELLAEYVIRTFAVEKggaggeancspsreVSQrgvHEIREIRQFHFtGWPDHGVPYHATGLLGFVRQVKS
 | ||.||| . |   .|.| |. . .              | .   .| ||.  . .  |.. .|| . . |.  . .|.|
lyGdilvtlkgrevkdryaistlllkr..............vdk...eesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1242-1491 1.2e-23 78.5 In-house 20-295 (297) alignment 
Range on Protein: 1242-1491
Range on HMM: 20-295/297.0
LRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGEsSNYINAALM--DSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLC
 | |. | |  .    |||  |||  |     |     | ..||||  .     ...  .|..| || .||.|||.|| .     .||.  .  |  . |
argesfssakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

PQYWPEN--GVHRHGPIQVEFVSADLEEDIISRIFRIYNAARpqDGYRMVQQFQFLGWPMYRdTP-----VSK------------RSFLKLIR-------
  |||.   .  . | . |||.|   .|     .  .    |  .  |.|.  |||.|| .   |     . .              .| |.        
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemftamvf

-QVDKWQEEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 |..  . |.   .  ..|||  | ||||      .. ..||..|  ||   .. ||.... .|  |.|....|...|. |
lqleslraemp.rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 949-1197 1.7e-23 77.5 In-house 49-344 (349) alignment 
Range on Protein: 949-1197
Range on HMM: 49-344/349.0
RMKNRYGNIIAYDHSRVRLQT--------------IEGDTNSDYINGNYID--GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK
  |||| .|. |.||||.|.                ..    |||| ||.    .   ..||||| |.  |. ||....  ..   .. ...  | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CCKYWPDDTeiYKDIKVTLIETELL----AEYVIRTFAVEKGGAG---GEANCSPSREVSQRGVH-EIR---EIRQFHFTGWPDHGVPYHATGLLGFVRq
| .|| . .  |..|.| | .. |        . | . |..        . ||   ..  .  .  . .   |. |. .  |.| .. .    .|  .  
cdiywqels..ysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqale.

VKSK-----------SPPSAGPLVVHCSAGAGRTGCFIVIDIMLD---MAEREGV--------V-DIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
||..                 .|.|||||| |||| .. .|..|.   . ..| .           |.  | |||  |..|||   |...|..|.|. .
vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 991-1190 6e-22 72.8 In-house 5-197 (199) alignment 
Range on Protein: 991-1190
Range on HMM: 5-197/199.0
NHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggEANCSPSrevsqr
 .||||| |..||. |||.|||   .  |.|| .      .    |||     |  |  . ||       ..|.| .. . .     .. . ||      
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.....nttapps......

gvheIREIRQFHFTGWPDHGVPYHATgLLGFV---RQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQ
     ||| .. || | ..  |  |  ..|||   |.|  |       |..|||| | | || |. .|| .   |  .  |||...  . ||  |. .. 
....treishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

TEEQYVFIH
. ..| ||.
slqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 992-1190 6.3e-22 72.7 In-house 5-196 (198) alignment 
Range on Protein: 992-1190
Range on HMM: 5-196/198.0
HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAEYVIRTFAVEKggaggEANCSPSrevsqrg
.||||| |..||. |||.|||   .  |.|| .      .    |||     |  |  . ||       ..|.| .. . .     .. . ||       
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn.....nttapps.......

vheIREIRQFHFTGWPDHGVPYHATgLLGFV---RQVKSKS-PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQT
    ||| .. || | ..  |  |  ..|||   |.|  |       |..|||| | | || |. .|| .   |  .  |||...  . ||  |. .. .
...treishyqftswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiiss

EEQYVFIH
 ..| ||.
lqhynfiy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1128-1195 3e-21 70.6 In-house 190-257 (267) alignment 
Range on Protein: 1128-1195
Range on HMM: 190-257/267.0
PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE
    ||||.||.| ||.| |.||| .|. | .|||.||.. .|..||.|. .|.| |.|..||. . |
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_eak_pd Subfamily eak 944-1196 1.1e-20 68.3 In-house 48-304 (332) alignment 
Range on Protein: 944-1196
Range on HMM: 48-304/332.0
KKDENRMKNrYGNIIAYDHSRVRLQTIEGdTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT-E
.. |.  .|   .|. ||.  ||| .     .  |||   ..  .  ..|| |  . .. .. ||.||  ... .|... . || .  |  ||.||.| |
arleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre

IYK--DIKVTLIETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTgWPDHGVPYHATG----LLGFVRQvKSKSPPSAGPLvVH
 .|   ..|.  |    . .  | . ..||    .         ..  .  ...   .. .   . ||.  ..     |  ....   ..|||  |. . 
elkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkv.mkevGvlllivmksallsstlkk.yihtppsfapi.iq

CSAGAGRTGCFIVIDIMLDMAE--REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA
.. |. |.| |.|||... . .  .. .  . . .   .|.|.  | .. |. ||....|. 
sarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1249-1479 3.7e-20 66.9 In-house 46-269 (301) alignment 
Range on Protein: 1249-1479
Range on HMM: 46-269/301.0
IALLPRnhEKNRCMDIlPPDRCLPFLITIDGESsNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGV
 | ||.  .|.|   . | .      .  ||.    | |  ...  .|  ||.|| ||.|| .||| ..  |.   .|||     .  . | .| | .  
yaylpk..dkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

HR--HGP--IQVEFVSADLEEDIISRIFRIYNAARPQDgYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFC
..   |   |...     |...|. | ... ....  .  | |  .|.  |.  |..| |.    .|.  | |        |   |||| .| ||| .| 
ekldigrfkikiknkelilnkkiskrtlevedstgkfa.trtvthyqysewtd.rgvPkshaelfdlmelvkk.......sekPivvhcsaGiGrsvafi

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQ
.  ..   .  ..|... .|.| ||... | |    |
gteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1382-1492 9.2e-20 65.4 In-house 277-386 (392) alignment 
Range on Protein: 1382-1492
Range on HMM: 277-386/392.0
YRMVQQFQFLGWPMY-RDTPVSKRSFLKLIRQVDKWQEeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQY
   | |.|| ||| .  |     ||.||||| |    .  .  |   .|||| | ||.| ||.       . .  .||.| .|| || .. ..|.  ..|
shtvtqyqfhgwpkhgsdqqsgarsllkliravkgstn..skkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeey

KFCYEVALEYLN
 | |.|  ||| 
afvydvireylh
subfamily_egg_pd Subfamily egg 1283-1488 8.5e-19 62.3 In-house 69-267 (307) alignment 
Range on Protein: 1283-1488
Range on HMM: 69-267/307.0
NYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPE--NGVHRH--GPIQVEFVSADLEEDIISRIFRIYNaARP
..| |  ..       ||..| || |||.||||.|   ..  .|||.    .. |. |||   .   .   | ...| .  | . | . |. ..     .
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGg

QDGYRMVQQFQFlGWPMYRDTpVSKRSFLKLIRQVDKwqeeynggegRTVVHCLNGGGRSGTFCAISI-VCEMLRHQRT-VDVFHAVKTLRNNKPNMVDL
.|  | .. .|   .    |   |    |...|.. |           .||.. .|  ...|. || | ....||   |   | .||. || ...  |. 
ddeerflehwqg.dvnnssdv.ysplrvlrklrnlsk..........pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

LDQYKFCYEVAL
  .| | | . |
vllylfvyrlvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1133-1197 9.6e-19 61.6 In-house 1-65 (69) alignment 
Range on Protein: 1133-1197
Range on HMM: 1-65/69.0
LVVHCSAGAGRTGCFIVIdiMLDMA--EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEAC
.|||||.|.|||| || |  |..||    | .|||.| |. .|  |  ||  | .|.|||||. || 
mvvhcssgtgrtgtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 946-1051 1.2e-18 62.0 In-house 31-132 (267) alignment 
Range on Protein: 946-1051
Range on HMM: 31-132/267.0
DENRMKNRYGNIIAYDHSRVRLQTIEGDtnsdYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMvWHENTASIIMVTNLVEVGRVKccKYWPDD---TE
 .|. .||. . . ||..|| |.| | .    |||  |..||.. |..|.||.|.. || ||. . .|..  ..|..   | .. ..  ..||     ..
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltv.ihdqkvpvivlltkvftdnir..lfwPPkmgqak

IYKDIKVTL
 |.|. |  
kyqdltveh
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1228-1490 2.6e-18 60.7 In-house 13-268 (281) alignment 
Range on Protein: 1228-1490
Range on HMM: 13-268/281.0
IKEEFRTLNMVTPTlrvEDCSIALLPRNHEKNRCMDILPPDRCLPFLI--TIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSV
.|.||  |    |.   . |..   | | .||| ..|   |     |     . .|..|| |  . |      .|.|| |  .|  ||||.. .   |..
fkqefsnlpgdpps...dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMLNDVDP--AQLCPQYWPENGvhrHGPIQVEFVSADLEEDIISRIFRIYNAARPQDG-YRMVQQFQFLGWPMYRdTPVSKRSFLKLIRQVDKWqeeyng
||| ..     . | .|.| |    |  .|.. .| . |.  . . .         .|  |.. .. .  || ..  | |   .||..|..         
vmlcqfletnrekcaeyfprna...hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwq.vpessevmlkilrkirar......

gEGRTVVHCLNGGGRSGTFCAISIVCEMLR-HQRTVDVFHAVKTLRN-NKPNMVDLLDQYKFCYEVALEY
     |.||  | |||||. |. |  . .. |    |. . |  ||   .   |. |.|| . ..| |..
.stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1240-1357 3.5e-18 60.2 In-house 30-158 (392) alignment 
Range on Protein: 1240-1357
Range on HMM: 30-158/392.0
PTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND------VD
|   . . ..|  . | .|||  .||| |.    |  | |   |.|.||. ..|...  |.| .| | . ...||||.|.. . |...|...       |
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

PAQLCPQY----WPENGVHRHGPIQVEFV
 |. . |.    ||...| .|    ..|.
dartvaqfhftewPdkdvpkhtssllkfi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 997-1190 4.4e-18 59.7 In-house 97-281 (302) alignment 
Range on Protein: 997-1190
Range on HMM: 97-281/302.0
QGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEyVIRTFAVEKGGAGGEANCSPSREVSqrgvHEIREIR
  | ..|.  .| .. . |.| .. ....|| .  || .|. |. .     .   ..|  . .  .  |.  |.      .   ..  .    .  . . 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvkt.dleeftdkksfklytveiknekkkk....kvkktvd

QFHFTGWPDHGVPYHATGLLGFVRQVKSKSppsaGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIH
 ..|..||||| | .|   |  ..  .|        ..|||||| |||| .. |   ...  .. | |. . |  .|. |   ||.|.| ... 
ilafsawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1134-1198 4.5e-18 59.4 In-house 1-65 (69) alignment 
Range on Protein: 1134-1198
Range on HMM: 1-65/69.0
VVHCSAGAGRTGCFIVIdiMLDMA--EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|||||.|.|||| || |  |..||    | .|||.| |. .|  |  ||  |..|.|||||. ||  
vvhcssGtGrtGtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
0048076 (Phosphotyrosine protein) phosphatases II 1371-1490 9.6e-18 59.7 In-house 35-142 (145) alignment 
Range on Protein: 1371-1490
Range on HMM: 35-142/145.0
RIynAARPQDGYRMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEEynggEGRTVVHCLNGGGRSGTFCAISIVCEmlrhQRtVDVFHAVKTLRNNK
..  .  ... .|.. |...|.|| . ..| . . .|...........|    .|...|||  | ||.||..|. .. .    .. |....|.. .|.  
nl..tselellerlgiqylylpwpDh.gvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqr

PNMVDLLDQYKFCYEVALEY
|..|   .|..|.||. ||.
pgavpnpgqlrflyefelel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1297-1486 1.1e-17 58.8 In-house 5-199 (199) alignment 
Range on Protein: 1297-1486
Range on HMM: 5-199/199.0
SAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLG
  .|.||||| .|. |||..| .     .||.|| .  .    | |||  |.|. ..| . |   .   . |     . . | .      | . ..||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPMyRDTP-VSK-RSFLKLIRQVDKWQEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT--VDVFHAVKTLRNNKPNMVDLLDQYKFCYEV
|   . || |.    |.   |.| |  |. .  .   .||| .| | .| | |. |        .|  ||.|   | ||. .  ..  |..|.| |.|
wke.kttpnvalfvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1298-1486 1.3e-17 58.6 In-house 5-198 (198) alignment 
Range on Protein: 1298-1486
Range on HMM: 5-198/198.0
AFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGW
 .|.||||| .|. |||..| .     .||.|| .  .    | |||  |.|. ..| . |   .   . |     . . | .      | . ..||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PMyRDTP-VSK-RSFLKLIRQVDKWQEEYNggEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT--VDVFHAVKTLRNNKPNMVDLLDQYKFCYEV
   . || |.    |.   |.| |  |. .  .   .||| .| | .| | |. |        .|  ||.|   | ||. .  ..  |..|.| |.|
ke.kttpnvalfvgfvvasrevskkyeqek..dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1227-1491 1.4e-17 58.3 In-house 25-289 (305) alignment 
Range on Protein: 1227-1491
Range on HMM: 25-289/305.0
QIKEEFRTLNMVT-PTLRVEDCSIALLP-RNHEKNRCMDILPPDRCLPFLitIDGESSNYINAALMDSYKQPS-AFIVTQHPLPNTVKDFWRLVLDYHCT
...|||| |   | | .          .  .  |||  |.   |. .  |   .   |.|| |  .     |   ||..| || .|. .|| .|.. .  
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

SVVMLN-DVDPAQL-CPQYWPENG---VHRHGPIQVEFVSAD--LEEDIISRIfRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkw
 .|||   |.  .| | ||||      .. .. | || ||    .| |   .|  . | .   |    |...|.  ||  |  |  | . |.|.  .   
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi.tllnltysgdqkmsvrhlqwtewpd.rgvppckltslellsai...

qeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTV-DVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
     | .   ||||  | ||.||  ||  . | .  .. .  . . ||.||...   ..   || | . | |.|.
....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 995-1195 4.1e-17 57.1 In-house 39-219 (255) alignment 
Range on Protein: 995-1195
Range on HMM: 39-219/255.0
AtqgpmqeTIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLieTELLAEYVIRTFAVEkggaggeancspsREVSQrgVHE
        |.  |....   .|  ..|.... | |..|| .|.|   |.  ...|..||   |.  |. |.||  .               ....    .
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtt..tkssadvvlrtleit.............stlge..kkk

IREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSkSppsaGPLVVHCSAGAGRTGCFIVIDIMLD-----MAERE-GVVDIYNCVRELRSRRVNMVQTEEQ
 .... ....||...  |  |  .|  .. |.  |     ..|||||.| ||.  |......       . . | . .|  . ..||||.|   ..|  |
thtvkhysykGWieknaPelareilnilkvvrd.s....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

YVFIHDAILE
  |    .|.
lafsilmvld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1274-1491 9.9e-17 55.9 In-house 59-271 (288) alignment 
Range on Protein: 1274-1491
Range on HMM: 59-271/288.0
LITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRhGPIQVEFVSADLEEDIISRIFR
 . .. ..  ||.| .. | | .  .| .| ||  |.. .|...|.     .|||...     .   .|.| .  ..   |.        . . | .. .
rvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek.arigrlctvvkkkradidklvk

I--YNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVdkwqeeyNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN
.   .  .. .   .|..  .| |.     | .  |.|.|.  .       .  .   |||. .| ||.||.  | |. |.|| .  . . . .. ||..
vsllriskegeekvivkilhlleWdd.dgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklree

KPNMVDLLDQYKFCYEVALEYL
. . .    || . . . ||.|
rfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1275-1491 3.9e-16 53.8 In-house 52-270 (285) alignment 
Range on Protein: 1275-1491
Range on HMM: 52-270/285.0
ITIDGESSNYINAALMDS-YKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVD--PAQLCPQYWPEN--GVHRHGPIQVEFVSADlEEDIISRI
. .     .|| |. |    |. |..| || |||.|. |||... . . . |.||  .     . |  |.||.   | . |  .. .  .  || |   |
vvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteck.eeaiagti

FRIYNAARPQDGYRMVQQFQFLGWPMYRD--TPVSKRSFLKLIrqvdKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLR
.        .|       ....  | . |  .|   | ...|     || .. |  |   .|||  | ||. ||  |      .  .  ....  |. .|
lnaltvintedasseplymnhvqvpwwpdqlapedarpmiely....kwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremr

NNKPNMVDLLDQYKFCYEVALEYL
  . . |.   |. | | | .||.
amrfqavqshmqflflyvvlmeyf
0048179 (Phosphotyrosine protein) phosphatases II 1369-1485 4.6e-16 54.3 In-house 30-139 (144) alignment 
Range on Protein: 1369-1485
Range on HMM: 30-139/144.0
IFRIYNAARPQDGYRM---VQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKWQEeyngGEGRTVVHCLNGGGRSGTFCAISIVCemlrHQRtVDVFHAVKT
|  ..| . . . . .   . |...|.||  ...| .   .|.... .....|     .|...|||  | ||.||..|. ..     ... .....|.. 
ittvinlteeyepefleregiqylhlpwp.Dhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealal

LRNNKPNMVDLLDQYKFCYE
.|.  |..|   .|..|..|
vrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1254-1493 1.4e-15 51.8 In-house 42-278 (312) alignment 
Range on Protein: 1254-1493
Range on HMM: 42-278/312.0
RNHEKNRCMDILPPDRCLpflITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN-------
. .. ||  .|   ||     .|. |.   || | ..    .|  |..|| || ||.  ||.|.|   .||...|  .  | .. | .|  .        
kfkdlnrypniqcwdrgr...ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--GVHRHGPIQVEfVSADLEEDIISRIFRIYNAARPQDGyrMVQQFQFLGWPMYrDTPVSKRSFLKLIRQVDKWQEeynggegRTVVHCLNGGGRSGTFC
   |.     ..| .     . |  |....   |  |.    ....|.  || .   | |  . |.|.  | | .          . ||  | ||.||..
dhrvyteycteie.iggkskdkithrvlkvvvkatgqes..klnhyqwaswpdh.gmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtla

AISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS
 |  .   ||| |  .| ..   ||...   |  . || ..  . ||.| |
liesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1383-1492 2.6e-15 50.7 In-house 89-195 (440) alignment 
Range on Protein: 1383-1492
Range on HMM: 89-195/440.0
RMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEEynGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
| ..|... |||  .  |      ||.|..|.. ||.   |.|  .|||  | ||.|   |.  .    ..   .|.|  ....|||.|.||.  .|| |
rtlkqyhyqgwpd.kgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYEVALEYLN
 .|. || | 
vheavlegll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 905-998 3.7e-15 49.9 In-house 5-95 (95) alignment 
Range on Protein: 905-998
Range on HMM: 5-95/95.0
IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTiegDTNSDYINGNYIDGYHRPNHYIATQG
| |. .  |. .|.      | .|. |      ||.     . |  |||. ||. || .|| | |     .|||||  ..||| | | |||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_CG42327_pd Subfamily CG42327 1127-1192 1e-14 48.9 In-house 244-310 (319) alignment 
Range on Protein: 1127-1192
Range on HMM: 244-310/319.0
PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIHDA
  | |||||||| |.||||  |  || .   |     ||| . |  .|  | . |.| ||| ||.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1254-1470 1e-14 48.8 In-house 51-269 (310) alignment 
Range on Protein: 1254-1470
Range on HMM: 51-269/310.0
RNHEKNRCMDILPPDRCLPFLiTID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVH-RH
..  |||  |..  | .   | .||     .|| |  . .    |.||..| ||  |. ||||....  . |...|  |       |  |||  ||   .
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GPIQVEFVSADLEEDIISRIF-RIYNAARPQDGYR---MVQQFQFLGWPMYRDTPVSKRSFLKlIRQVDKWQEEynggEGRTVVHCLNGGGRSGTFCAIS
| |.|  .|   ||  |  .   .     | |         . ... || . |. |        . |    |       |  ||||  | .| .. .|. 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht.vpqrllaqvr....hgpcvvhcsagkdrlyvvvalk

IVCEMLRHQRTVDVFHAVKTLRNNK
.  . |..   ||. . .  |....
lkidkldrglkvdaeevktellksr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 947-1198 1.6e-14 48.2 In-house 46-280 (303) alignment 
Range on Protein: 947-1198
Range on HMM: 46-280/303.0
ENRMKNRYGNIIAYDHSRVRLqtiegdTNSDYINGNYIDgYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKD
.|  |||. ..|  |||.|.|      ..| ||  .|..  .  .. | || |.. |  |||.|. ...   ....    |  ..     .| . .. | 
knmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

IKVTlIEtelLAEYviRTFAVEKGGAGGeancspSREVSQRGVHEIreIRQFHFTGWPDHGVPYH-ATGLLGFVRQVKS---KSPPsAGPLVVHCSAGAG
 . . |    . |.  .   . .| .           ||.   . .  .   |.  ||   .| . .  ..  . |..|   |  . . | |    .| |
eers.ir...vgef..krvelgdgwvlk......vlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysd.stptvymslsgcg

RTGCFIVIDI-MLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
|.| | ...   | . . .  .|. .|.  .|  |.  ||   |. ...  . |  |
ragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1254-1490 1.4e-13 45.1 In-house 46-278 (303) alignment 
Range on Protein: 1254-1490
Range on HMM: 46-278/303.0
RNHEKNRCMDILPPDRClpfliTIDGESSNYINAALMDSYKQPSAfIVTQHPLPNTVKDFWRLVLDYHCTSVV-MLNDVDPAQLCPQY-WPENGVH---R
.| .||| .|..  |        .    | || |. ..   .  | |.|| ||. |  |||..... .   |. .| | .  .|  .. .|.|       
knmdknrfvdvicldhs.....kvklsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

HGPIQV-EFVSADLEEDIISRIFRIYNAArpqdGYRMVQQFQFLGWPMYrDTPVS-KRSFLKLIRQVDKWQEEYNGGEgRTVVHCLNGGGRSGTFCAISI
.  |.| ||   .| .    ..  . |         ...  ..  ||   . |      |.| | |..     |  ..  ||   | | ||.|||. .  
ersirvgefkrvelgdgwvlkvlsvsngd....yksflhvhhykawphn.sipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfet

VCE-MLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
    .   | ..|. . ....|| .   |. | |. . | .  |.
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1291-1353 1.9e-13 44.6 In-house 230-292 (440) alignment 
Range on Protein: 1291-1353
Range on HMM: 230-292/440.0
DSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDpAQLCPQYWPENGVH-RHGPIQ
. | .  ||| || ||  || |||||| ||. ....|||...  . |  ||| |      ||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln.dktcsiywpvntrsvtfgpft
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 905-986 4e-13 43.5 In-house 6-85 (440) alignment 
Range on Protein: 905-986
Range on HMM: 6-85/440.0
IRVADLLQHITQMKCAEgyGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDG
| |||. ... . . .    |..|.  .  | | | | |   .|..|||| ||.||||||| |. ..|  .|||||  ||.|
iivadfadyvqnnrrsr..afedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_hpo-7_pd Subfamily hpo-7 1000-1192 5.1e-13 43.5 In-house 43-222 (263) alignment 
Range on Protein: 1000-1192
Range on HMM: 43-222/263.0
MQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP---DDTEIYKDIKVTLieTELLAEYVIRTFAVEKggaggeancspsrEVSQrgVHEIREIR
. .||  |....   .|  ..|...  | |..|| .|.|   |.  ......|.   |.   . ...|  . .              ...    ......
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlells.............tlge..Kkkthtvk

QFHFTGWPDHGVPYHATGLLGFVRQVKSkSppsaGPLVVHCSAGAGRTGCFIVIDIMLD-----MAERE-GVVDIYNCVRELRSRRVNMVQTEEQYVFIH
.. ..||...  |  |   |  .. ..  |     .||||||.| ||.  | |....       . . . . .|  . ..||||.|   ..|  |  |  
hysykgWiekndpelareilnilkvarn.s....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

DA
  
lm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1280-1491 6.9e-13 43.0 In-house 71-287 (305) alignment 
Range on Protein: 1280-1491
Range on HMM: 71-287/305.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPENGV-----H-RHGPIQVEFVSA---DLEEDIISR
   .|| |  . .  .|  || || || .|  ||| . |. .  .. || ..    |. | .|.. .       . .   |.| | |.   ....|  ..
wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

IFRIY-NAARPQDGYRMVQQFQFLGWPmYRDTPVSKRSFLKLIRQVDKwqeeyngGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTV-DVFHAVKTL
. .       |    | |... .  ||  |  | .  . |.|. .            | .||||  | ||.|.   .  ... |   . . |  . .. .
vtetvlviegpgekarkvthyhwidwp.drgvpaadlailellekarp.......skgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqki

RNNKPNMVDLLDQYKFCYEVALEYL
|... | ..  .|| | ..| |.|.
reqrnnsiqtdaqylfvhqvilnyf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 943-1054 8.6e-13 42.5 In-house 91-198 (244) alignment 
Range on Protein: 943-1054
Range on HMM: 91-198/244.0
AKKDENRMKNRYGNIIAYDHSRVRLQtiEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWhENTASIIMVTNLVEvgrvKCCKYWPDDT-
| . .|  ||| |  . .| .|| |   .|     |||  ..    |   || || |. .|  |||.|.  |    ...|   ||    .  .||||   
afnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsve....eedeywpdsep

-EIY-KDIKVTLIET
 | | .|| ||| . 
lewyeeditvtltdr
fn3 Fibronectin type III domain 498-574 1.4e-11 37.6 Pfam-A 15-84 (85) alignment 
Range on Protein: 498-574
Range on HMM: 15-84/85.0
KIFLQWREPTQTYGVITLYEITYKAVSSFDpeidlsnQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPP
.. |.| .|..  | || ||..|. ... .       .. ...  ...|.. . || |||.|.|...| ...| ||.
sltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_CG42327_pd Subfamily CG42327 1424-1490 1.6e-11 38.5 In-house 247-314 (319) alignment 
Range on Protein: 1424-1490
Range on HMM: 247-314/319.0
EGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ-RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
 |  |||| .| ||.|.  |  |  . | .  |.||. . |  .|... . |   .||.| | |. ||
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 947-1029 2e-11 38.0 In-house 33-114 (332) alignment 
Range on Protein: 947-1029
Range on HMM: 33-114/332.0
ENRMKNRYGNIIAYDHSRVRLQTIEGdtNSDYINGNYIDGYHRPNHYIATQGPMQE-TIYDFWRMVWHENtASIIMVT-NLVEVG
.|   ||   . ..||||| |   .|  . |. | ...||| . . || .| |... | | |||||   .  |.|.|  .. |  
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserk.psmilvfgdidekq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1099-1194 2.9e-11 37.3 In-house 187-282 (302) alignment 
Range on Protein: 1099-1194
Range on HMM: 187-282/302.0
HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAIL
..| |... || . . |   . .|  |. ..  ..|.    |||| | |..  . ..  ...  . | . |. .|| | ..|.. .|||... |.|
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1282-1484 5.7e-11 37.1 In-house 46-252 (290) alignment 
Range on Protein: 1282-1484
Range on HMM: 46-252/290.0
SNYINAALMdSYKQPSAFIVTQHPLPN-------TVKDFWRLVLDYHCTSVVMLNDVDPAQ------LCPQYWPENG--VHRHGPIQVEFVSADLEEDII
..|| |  . .. .  ..|.|| |. .       |...|| .. . . ..|||| ...  .       | .| ||.     . . ..|.  |   |.|..
ddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

SRIFRIYNAARPQdgyRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWqeeynggEGRTVVHCLNGGGRSGTFCAISIVCEMLR-HQRTVDVFHAVKT
 |   .    . .     |.  .. || . . .. .....|.||..| .        .   .||| .|  || .. || . . ..   .  | .  ..|.
tRelvvkfddeee...ftvtHsllkgWnk.lnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

LRNNKPNMVDLLDQYKFCY
||... ...    .. |  
lrkqralaitsalelafvd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 947-1111 6e-11 35.5 In-house 26-157 (169) alignment 
Range on Protein: 947-1111
Range on HMM: 26-157/169.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGnyidgyhrpnhyiatqgpmqetiydfwRMVWHENtASIIMVTNLVEvgrvKCCKYWPDDTEIYKD
 |  |||    .|  | ||.|| .  |  |||||                            ||.|  | ||.|.|    .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetn.asvivvlgdtd....dknnfwpekedyqlh

IKVTLIETELLAEYvIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYH
  | | |    . | .||  |..  .| |.    |  . .   .   ... .|.. ||. |||  
pavilgewytdsly.vrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1250-1344 6.1e-11 36.4 In-house 91-181 (244) alignment 
Range on Protein: 1250-1344
Range on HMM: 91-181/244.0
ALLPRNHEKNRCMDILPPDRCLPFlITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQlcpQYWPEN
|. | |  |||    || |      ..    .  ||||...    . . .|.||||| .|  |||...|. |   .|.|  |.  .   .|||. 
afnpnnswknregaglpfdfnrvp.lskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...eywpds
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1406-1491 1.1e-10 35.5 In-house 200-285 (302) alignment 
Range on Protein: 1406-1491
Range on HMM: 200-285/302.0
FLKLIRQVDKW-QEEYNgGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
. .||... |  ... . .. .||.   || || |.| .  .. | | ..  . .   ||..|...|..|| |.|| . | ..| |.
yaeliktaakvfakkik.adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 947-1111 2.2e-10 33.6 In-house 25-156 (169) alignment 
Range on Protein: 947-1111
Range on HMM: 25-156/169.0
ENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGnyidgyhrpnhyiatqgpmqetiydfwRMVWHENtASIIMVTNLVEvgrvKCCKYWPDDTEIYKD
 |  |||    .|  | ||.|| .  |  |||||                            ||.|  | ||.|.|    .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetn.asvivvlGdtd....dknnfwpekedyqlh

IKVTLIETELLAEYvIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYH
  | | |    . | .||  |.   .| |.    |  . .   .  .... .|.. ||. |||  
pavilGewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1256-1457 3.5e-10 34.4 In-house 30-185 (255) alignment 
Range on Protein: 1256-1457
Range on HMM: 30-185/255.0
HEKNRCMDILppdrclpflitidgessnyinaalmdsykqpsafivtqhplpnTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ
 .|.. ...|                                           ||. |.. .     . |||| |      . | .|.| .   .    .
dkkrknlysl...........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad

VEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMyRDTPVSKRSFLKLIRQVDKWQEeynggegrTVVHCLNGGGRSGTFCAISIVCE-MLR
|. ....   |.. |  .|      .   . |. ... ||.  . .|   |  |.... | . .          |||| .|.||| .|  . .|   |.|
vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWie.knaPelareilnilkvvrdsks........vvvhCstGiGrsaafvlaelvyqkmir

HQRT---V
  .|   |
sldttetv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1428-1492 3.8e-10 34.0 In-house 1-65 (69) alignment 
Range on Protein: 1428-1492
Range on HMM: 1-65/69.0
VVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN
||||  | ||.||| || .    .. .. ||.|  |. .|  .| ||   ..| | ..   | | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_hpo-7_pd Subfamily hpo-7 1301-1456 6.1e-10 33.4 In-house 42-187 (263) alignment 
Range on Protein: 1301-1456
Range on HMM: 42-187/263.0
VtqhpLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRD
.    | .|.. |.. .     . |||| |   .  . | .|.| .   .    .|. ....  .|.. .   . .    .   . |..... ||.  .|
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

tPVSKRSFLKLIRQVDKWQEeynggegrTVVHCLNGGGRSGTFCAISIVCE-MLRHQRT
 |   |. |.... . . ..         |||| .|.|||  |  . .|   |.|  .|
.pelareilnilkvarnsks........lvvhcstGiGrsaafsvaElvyqkmirsldt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 984-1041 8.1e-10 32.6 In-house 229-283 (440) alignment 
Range on Protein: 984-1041
Range on HMM: 229-283/440.0
IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEvgrVKCCKYWPDDT
..|| . | .|||| |.. |. ||||.|   . ..|||. .| .     |  ||| .|
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1428-1491 9e-10 32.8 In-house 2-65 (69) alignment 
Range on Protein: 1428-1491
Range on HMM: 2-65/69.0
VVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
||||  | ||.||| || .    .. .. ||.|  |. .|  .| ||    .| | ..   | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1280-1349 1.3e-09 32.2 In-house 81-158 (350) alignment 
Range on Protein: 1280-1349
Range on HMM: 81-158/350.0
ESSNYINAALMDSY----KQPSAF--IVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA--QLCPQYWPENGVHRH
....||||  .       .. . |  | || |||.||.||....|  . . ...|.. .    . | .||.| ... .
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsyddi
subfamily_CG42327_pd Subfamily CG42327 1226-1355 2.2e-09 31.4 In-house 5-136 (319) alignment 
Range on Protein: 1226-1355
Range on HMM: 5-136/319.0
SQIKEEFRTLNMVTPTLRvedcsiALLPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQ-PSAFIVTQHPLPNTVKDFWRLVLDYHCT
... |||| |  .           .. .  ..|.| ....|     . |  | | ....|..|. .  |.. |. .| .| .| ..  ||||.| .    
edvaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsr

SVVMLNDVDPAQ--LCPQYWPEN----GVHRHGPIQVE
 .| | |.       |..|.| .    . . .| |.| 
vivqltdlselGikvcaeylPtketldntslyGdilvt
fn3 Fibronectin type III domain 287-361 4.4e-09 29.5 Pfam-A 5-80 (85) alignment 
Range on Protein: 287-361
Range on HMM: 5-80/85.0
PPQLASVGATYLWIQLNANSiNGDGPIVAREVEYCTASGS--WNDRQPVDST-SYKIGHLDPDTEYEISVLlTRPGEG
 ... .|..|.| .. .. . .|.|||.  ||||....|.  |. ..   .| |... .| |.||||..|  .. |.|
nlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq.avngag
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1099-1204 1.1e-08 29.6 In-house 164-257 (290) alignment 
Range on Protein: 1099-1204
Range on HMM: 164-257/290.0
HFTGWPDHGVPYHATGLLGFVRQVKSKsppsAGPLVVHCSAGAGRTGCFIVIDIMLDMA-EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILeac
 . || .  |. .   ||  ...|| .      | .|||  |  |  ..  |..   .  | .| | . . . .||..| ......... |.  .|.   
llkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...

lcgdtsV
      .
......l
subfamily_eak_pd Subfamily eak 1257-1401 1.1e-08 28.9 In-house 54-196 (332) alignment 
Range on Protein: 1257-1401
Range on HMM: 54-196/332.0
EKNrCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLN-DVDP-AQLCPQYWPENG--VHRHGPI
..|  ..|.| || |  | .   .   ||||.|..  .    .|.|  .  . |  ||..||. .  ..|.|  ||.   .   .|.|...  . ..| .
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

QVEFVSAdLEEDIISriFRIYNAARPQDGYRmVQQFQFLGWPMYrDTPV
.||  .  ....|.   .| .   .  . .| |. ... ||  . ..|.
dverkef.vkrnile..trllelskGnethr.vlhykvfGwtet.tlpk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1280-1328 2.3e-08 27.9 In-house 68-116 (347) alignment 
Range on Protein: 1280-1328
Range on HMM: 68-116/347.0
ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVML
.. .||||. .   .    .|.||.|||.||.|||..|   . | || .
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PTPDC1_pd Subfamily PTPDC1 1098-1191 3e-08 28.3 In-house 85-170 (182) alignment 
Range on Protein: 1098-1191
Range on HMM: 85-170/182.0
FHFTGWPDHGVPYhATGLLGFVRQVKSKSppSAGPLVVHCSAGAGRTGCFIVIDIMLdmAERegvVDIYNCVRELRSRRVNMVQTEEQYVFIHD
..  ||.|.||.   . .|  |. |..    . | . ||| || ||||  |   ..   |.|   ..  . .. .||.| . .|| ||  ....
vynfgwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylvy..akr...ltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 1388-1483 3.7e-08 28.8 In-house 80-169 (194) alignment 
Range on Protein: 1388-1483
Range on HMM: 80-169/194.0
FQFLGWPMYRD-TPVSKRSFLKLIRQVDKWQEEYNGGegRTVVHCLNGGGRSGTFCAISIVCemlrhQRTVDVFHAVKTLRNNKPNMVDLLDQYKFC
...| .|.  | |. |    |. .. ||.. .| .||    .|||  | ||.||..|  ...      .  ..  |....|  .|...   |...  
ieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleal
ig Immunoglobulin domain 199-261 3.8e-08 24.6 Pfam-A 1-63 (64) alignment 
Range on Protein: 199-261
Range on HMM: 1-63/64.0
GQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCM
|. .|..||. ....  |  | .. ...  . |   |. . . . .... |.|| |.| |.|.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1282-1348 1.2e-07 26.1 In-house 13-76 (130) alignment 
Range on Protein: 1282-1348
Range on HMM: 13-76/130.0
SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQlcpQYWPENGVHR
 .|||| ..    . . .. ||||| .|  |||...|. .   .|.|  |.  .   .|||.     
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed...eywpdsePle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1279-1344 1.3e-07 25.3 In-house 87-156 (349) alignment 
Range on Protein: 1279-1344
Range on HMM: 87-156/349.0
GESSNYINAALMD--SYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWPEN
|   .||||  .    ..    .| || ||| ||.||....|      |. ||| .  .|  | .|| | 
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 946-1022 3.2e-07 24.2 In-house 35-116 (347) alignment 
Range on Protein: 946-1022
Range on HMM: 35-116/347.0
DENRMKNRYGNIIAYDHSRVRLQT-----IEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMV
. .  |||  .    | .|| |        . |    |||  .|      ..|| || |. .|. |||.||   . . .. .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 959-1053 4e-07 24.4 In-house 4-88 (130) alignment 
Range on Protein: 959-1053
Range on HMM: 4-88/130.0
AYDHSRVRlqtiegdtNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWhENTASIIMVTNLVEvgrvKCCKYWPDDTEIY---KDIKVTLIE
 .. ||..        . .||| ...    | . |. || |. .|  |||.|.  |    ...|   ||    .  .||||   .    .|| ||| .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsve....eedeywpdsePlewyeediivtltd
0038934 (Phosphotyrosine protein) phosphatases II 1101-1187 5e-07 25.1 In-house 85-170 (194) alignment 
Range on Protein: 1101-1187
Range on HMM: 85-170/194.0
TGWPDHGVPYHATGLLGFVRQVKSKSPPS-AGPLVVHCSAGAGRTGCFIVIDIMLDmaEREGVVDIYNCVRELRSRRVNMVQTEEQYV
  .||.|..     || |.. |. .   .  |  .||| || ||||....  ..     .  . . .. .|| |   .. ..  |...
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRpgaipnqdyleall
I-set Immunoglobulin I-set domain 191-267 7.3e-07 20.9 Pfam-A 7-80 (90) alignment 
Range on Protein: 191-267
Range on HMM: 7-80/90.0
IQNVEVNAGQFATFQCSAIGRtVAGDRLWLQGiDVRDAPLKEIKVTSSRrFIASFNVVNTTKRDAGKYRCMIRTEGG
...|||. |. ....|.. |     .  |... .   .. ...||| .   .... . | ...|.|||.| .. . |
lkdvevseGesvelectveGe.pepsvsWakd.gselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsag
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 947-1067 9e-07 23.3 In-house 18-150 (290) alignment 
Range on Protein: 947-1067
Range on HMM: 18-150/290.0
ENRMKNRYGNIIAyDHSRVRLQTIEGDTNSDYINGNYIDgYHRPNHYIATQGPMQET-------IYDFWRMVWHENTASIIMVTNLVEVGRV----KCCK
.. |..|. . ..  ..|| |.      |.|||  |..  .    . |.|| | ...       | .|| |.  |.  ...|. .  |  .      | |
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPDDTE---IYKDIKVTLIETELLAEYVIRTFAV
| |.  .    .|...|   . |   .  .|.  |
YvpesvgeelkfkgltvkCkskekeddvetRelvv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 947-1050 1.1e-06 22.3 In-house 50-151 (302) alignment 
Range on Protein: 947-1050
Range on HMM: 50-151/302.0
ENRMKNRYGNIIAYDHSRVRLQTiegdTNSDYINGNYIDGYHRPNHYIATQGPMQETI---YDFWRMVWHENTASIIMVTNLVEVGRvKCCKYWPDDTEI
.|  ||.  .. ..|. .|.|..    .. .|.|.  ..  .  .  | .| | ...     .|||||..|. .|. ..    |. .    ...|  .. 
knlkknqsedvpildsnlvklea....epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

YKDIKVT
||. .  
ykeygkm
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1426-1490 1.1e-06 22.6 In-house 264-343 (350) alignment 
Range on Protein: 1426-1490
Range on HMM: 264-343/350.0
RTVVHCLNGGGRSGTFCAISIVCE---ML----RHQR-------TVD-VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY
  .|||  | || ||....  . .   .|    .. |       | | ..  |. ||. . .||  |||. |.|| .| |
pilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1304-1470 1.2e-06 22.2 In-house 98-267 (302) alignment 
Range on Protein: 1304-1470
Range on HMM: 98-267/302.0
HPLPNTVKDFWRLVLDYHCTSVVMLNDV--DPAQLCPQYWPEN--GVHRHGPIQVEF--VSADLEEDIISRIFRIYNAAR-----PQDGYRMVQQFQFLG
 |  .|.. .| |. .|. . || | ..  |  . | .|. ..  |. . |   |.   |  ||||    . |..|.         ..  . |. ..| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPMYrDTPVSKRSFLKLIRQVDKWQEEynggegrTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK
|| .  .|    . |....  . ....        .||| .| ||.||. ||    ..  .... |. . |. .|. .
wpdh.Gapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcr
DUF1191 Protein of unknown function (DUF1191) 698-804 1.5e-06 14.5 Pfam-A 138-250 (278) alignment 
Range on Protein: 698-804
Range on HMM: 138-250/278.0
YRIYFQAASRANG--ETKIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAAT-PKPVPEP----EKQTDHTVK-IAGVIAGILLFVII-FLGVVLV
 |. |. ||.|..  ...  || .. .. . ...  ...      .|.  |   ..  || .||    ||.  .. | . .|. |. | ... .| ||.|
irvdFsdassasqpgasaarcvvfelngeatiseqvksnvCatsrqGhyalvvkseakkpkvepegesekeklsrWkvvgsvvgGvvllgllavlvvvvv

MKKRklaKKRKETMSS
  ||   ||..| |  
rakr...kkkreemer
PepSY_TM_3 PepSY-associated TM helix 768-790 2.6e-06 13.4 Pfam-A 10-32 (37) alignment 
Range on Protein: 768-790
Range on HMM: 10-32/37.0
IAGVIAGILLFVIIFLGVVLVMK
..|...|.||..... |.| | .
WlGlalglllllwflsGlvmvfr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1427-1491 3.5e-06 20.6 In-house 268-344 (349) alignment 
Range on Protein: 1427-1491
Range on HMM: 268-344/349.0
TVVHCLNGGGRSGTFCAISIVCEMLRH-----------QRTVD-VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL
 .|||  | ||.|... . .. ..|             . . | .. .| .||  . .||  | |. ..||  |.|.
llvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
DctM DctM-like transporters 767-812 5e-06 11.5 Pfam-A 171-216 (416) alignment 
Range on Protein: 767-812
Range on HMM: 171-216/416.0
KIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVM
 .|..|.|.||.|...| |... ||..| .| |... . .| .   
faaalipglllavglllavaiaakkenlssktkaelkrllqalkea
Ig_3 Immunoglobulin domain 193-263 6.2e-06 18.3 Pfam-A 10-74 (75) alignment 
Range on Protein: 193-263
Range on HMM: 10-74/75.0
NVEVNAGQfATFQCSAIGRTVaGDRLWLQgidvRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIR
......|   |..||| |     .... .    .. | .  .. .|.   ..... ..|  | | |.|...
ptvtsggn.vtLtCsaeggpp.pptisWy....ietppelqgsegssssestLtissvtsedsGtYtCvas
PTEN_1 1353-1443 6.3e-06 21.1 In-house 52-149 (196) alignment 
Range on Protein: 1353-1443
Range on HMM: 52-149/196.0
QVEFVSADLEEDIISRIFRIYNAARPQDG----Y----RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGgEGRTVVHCLNGGGRSGTFCA
....|.|||..   . |. ..| .   .     |    .. .....|  |.  ... | ..... ..... |  . .  ..  .|||  | ||||| .|
slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva
fn3 Fibronectin type III domain 383-466 6.9e-06 19.3 Pfam-A 3-80 (85) alignment 
Range on Protein: 383-466
Range on HMM: 3-80/85.0
PRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVhycYQVGGQEqvrEEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEG
|. | | || |...|..|.|   .     .|....    ..||.|   |... .........|.|.| |.|. ....   | .|
PenlsvsevtstsltlsWsppkdgggpitgYevey...rekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngag
Ig_2 Immunoglobulin domain 192-278 7.5e-06 17.9 Pfam-A 7-80 (80) alignment 
Range on Protein: 192-278
Range on HMM: 7-80/80.0
QNVEVNAGQFATFQCSAIGRTVAgDRLWLQGidvrDaplKEIKvtSSRR--FIasfnvVNTTKRDAGKYRCMIRTEGGVGISNYAELVV
....|..|.  |. |.| |.  . .  | ..    .   .|..  .|..  ||      |..  |.|.|.|. . ..|   ||. |. |
pptvvtegenvtLtCqapgnptp.kvqwykd....g...eels..qsqnalfi.....pnvsaedsGtYtCrasnsegskqsnsvevtv