Gene PTPRU in Homo sapiens

Synonym: FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J, PTPRU

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRK
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP104_AA protein Get Run
HsapP104_AA_876-1146 phosphatase_domain Get Run
HsapP104_AA_1158-1441 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRK_pd Subfamily PTPRK 871-1182 5.1e-172 565.9 In-house 1-314 (314) alignment 
Range on Protein: 871-1182
Range on HMM: 1-314/314.0
HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVY
|||.|||||||.|...|.|||||||.||||.||||||.||... . .|.... ||||.||.|... |||..|||||..||.|.|...||.||||..|.|.
hpairvadllqsiallkraegygfkeeyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALER--RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIR
||||.|..|.|.||||.|.|||||||||..|||||...|||||..||.||.|||.|||.|..|.  ||.....|||||.|..||.|.||..|||||...|
dfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvr

RVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRID
|||.|....||.||.|||||.||||..|..|..|||.|.|||||..|.||||.||.|||..|||||.||.|.||||||||||.||||||||.|.|.||.|
rvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirld

PQSNSSQLREEFQT
||.|||||.|||||
pqtnssqlkeefqt
subfamily_PTPRD_pd Subfamily PTPRD 871-1219 3.4e-130 430.3 In-house 2-354 (564) alignment 
Range on Protein: 871-1219
Range on HMM: 2-354/564.0
HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKG----SRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKP
.... ||.| .|....|. ... |..||... ||   |... . .      | .   |||. ||.|... ||.. |||||..||||......||||||..
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

EMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLA
| . |||||||....|.|||.|||.| |.|||..||||. . |||.... |...|.||.|..||| |..   |  .||||||||.||.|||| .||.||.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI
.||.|.|...|||||||.||||| ||||..||.|.||. .. |..||||..||.| . |  |.||||||||||.|||||  ||.| ......|.. ... 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

RIDPQSNSSQLREEFQTLNsVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCL
..........|  ||| |.  . . ..|| . |  |.|..|||  ..|. ..| 
eveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescr
subfamily_PTPRK_pd Subfamily PTPRK 1202-1438 3.8e-110 362.6 In-house 42-275 (314) alignment 
Range on Protein: 1202-1438
Range on HMM: 42-275/314.0
RNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLnQSNSAWPCLQYWPEPGRQqY
 ||.||||.|.|..||...|||..||| |..||||||.|||.|.|||||| .|||.|. ||||||||..|.|||||..| .......||.|||| ... |
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev.y

GLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAEsGDGRTIVHCLNGGGRSGTFCACATVLEMI
| ..||... .....||.|.|||....| ||.. .||.||||.|... |.| |....|.|...|.|.|.| ..||..|||..|.||.|||.|...||.||
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
.....||||.|.||||..|.|||||..||.|.|||.||
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 874-1183 5.8e-102 336.0 In-house 2-318 (318) alignment 
Range on Protein: 874-1183
Range on HMM: 2-318/318.0
VRVADLLQHINQMKTAEGYGFKQEYESF------FEGWDATKKKDKVKgSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPE
. | || .|......     ...||| .      .   ..... .| |  |   . |||. ||||... |....|||||||||||.|.. .||.|.| ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkak.nryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe

MVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAF
 . |||||||. ... |||.|...| |..|. ||||.. | .||.... | .. .|..||.|.| ..|.. ..  .|||.|.|.||..||| ....||..
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

IRRVKAST-PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI
.|.|..   ...|||||.||||| |||| .|..|..|. .. |..||... ||.| ..|  |.|||.||.||.|..|||  .|.| .  |....  .|. 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

RIDPQSNSSQLREEFQTL
. ||.|  ...  ||| |
eqdpesgttemdaefqrl
0040438 (Phosphotyrosine protein) phosphatases II 878-1181 2.8e-93 308.0 In-house 4-312 (317) alignment 
Range on Protein: 878-1181
Range on HMM: 4-312/317.0
DLLQHINQMKTAEGYGFKQEYESFFE----GWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFW
|||.......    .....|.| . .     .. .....  .  |    . ||. ||||.|. ||.. |||||.|.||......|||||||.|. |.|||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA
||||......|||.|.|.| ||.|| .||| ... ||||... |...|.||....||. .|  | |  ..|..||.|.||.||||.. . ||.|...|..
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSN
. ... ||...||||| ||||..|....||.. | || ||....||.| ..| ...||.|||.|..||.|| .....| .|.||.|  .... .......
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

SSQLREEFQ
..   .|..
vklkekelk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 874-1181 8.7e-93 305.9 In-house 5-319 (319) alignment 
Range on Protein: 874-1181
Range on HMM: 5-319/319.0
VRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMV
..|..| .........   ....|.. . |.    .| ..|..  |  | . . |||| ||.| .. | ...|||||..||||.. . |||||.|. . .
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

YDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS-DTYGDIKIMLVKTETLAEYVVRTFALERRGYSA-RHEVRQFHFTAWPEHGVPYHATGLLAFI
 |||||||.|..| .||.||||| ..||...||||    .|| . . | . | |..|..| . |...       || .|..|.||.|.|| .||.||...
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

RRVKASTP-PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR
.|.. |.  ...||||.||||| |||| .||||.||.  . |||.|... |..|   |  |.|..|||.||..|.|||  .|.| | | ...   |..  
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlae

IDPQSNSSQLREEFQ
 ....  ..|  |||
kvadtgetglerefq
0051299 (Phosphotyrosine protein) phosphatases II 873-1145 6.3e-92 303.3 In-house 4-286 (288) alignment 
Range on Protein: 873-1145
Range on HMM: 4-286/288.0
AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW-----DATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPE
...| .||.......    .|...|.| ... .      |....  ..  |    ..||. ||||... |... |||||.|||||.....|||||||.|.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

MVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALERR----GYSARHEVRQFHFTAWPEHGVPYHATG
 |.|||||||..... |||.||||| ||.|| .||| ..| |||||.. |...|.|..|.|||. ...     | .  ..|..||.|.||.|||| ... 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
||.|.|.|. . ... ||.|.||||| ||||..|.||..|.. |.||.||... ||.|...| .|.||.|||.|...|.||..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 871-1150 1e-90 299.5 In-house 23-304 (308) alignment 
Range on Protein: 871-1150
Range on HMM: 23-304/308.0
HPAVRVADLLQHINQmkTAEGYGFKQEYESFFEGWD-----ATKKKDKVKGSRQEPMPAYDRHRVKLhpmlgDPNADYINANYIDGY--HRSNHFIATQG
.  ..| |||.....    . .....|.| ...  .     ...... ..  |    ..||. ||||     |.. |||||.|.|||  .....||||||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE----DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYH
|.|. |.|||||||..... |||.||||| ||.|| .|||.    .| .||.... |...|.|..|.|||. |.  |..  ..|..||.|.||.|||| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

ATGLLAFIRRVKASTPPdaGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET
.. ||.|...|. | |.  ||||.||||| ||||..|.||..|.. |.|| ||....||.| ..| .|.||.|||.|...|.|| ... .|
peilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_PTPRB_pd Subfamily PTPRB 873-1145 4.5e-90 296.6 In-house 6-285 (293) alignment 
Range on Protein: 873-1145
Range on HMM: 6-285/293.0
AVRVADLLQHINQMKTAEGYGFKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPE
 ... .. .|...||. . ..|..|||.. .       .|.... . .  | . . .||  ||||... .....||||||||.||.  ..||||||| ||
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

MVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED--SDTYGDIKIMLVKTETLAEYVVRTFALERrgYSARHEVRQFHFTAWPEHGVPYHATGLLA
 | |||||||....| |||.|.||| |.||| .|||.|  . .|||||. ||..|.| ..|.|....|.   .....|||.|||.||.|||| ... ||.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FIRRVKAST--PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
|.|.|. ..    ...|||.||||| |||| .| || .|.  | | .|||.  |  | ..|....|||.||||||...|. .
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0036941 (Phosphotyrosine protein) phosphatases II 900-1159 4e-89 294.1 In-house 21-291 (297) alignment 
Range on Protein: 900-1159
Range on HMM: 21-291/297.0
SFFE-----GWDATKKKDKVKGSRQEPMPAYDRHRVKLhpmlGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVG
....      ........ ..  |    ..||. ||||    .|.. |||||.|.|||.....|||||||.|. |.|||||||......|||.|.||| |
ellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelg

RVKCSRYWP---EDSDTYGDIKIMLVKTET--LAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA--STPPDAGPIVIHCSA
|.|| .|||   ..| ||||... |...|.  |..|..||. ..  |..  ..|..||.| ||.|||| ... ||.||..|.   .  |. ||...||||
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GTGRTGCYIVLDVMLDMAE---CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA
| ||.|..|..|.||.. |    || |||...||.| ..| ...||.|||.|...|.|| .....| .|..... 
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
subfamily_PTPRG_pd Subfamily PTPRG 874-1159 7e-89 293.5 In-house 1-301 (563) alignment 
Range on Protein: 874-1159
Range on HMM: 1-301/563.0
VRVADLLQHINQMKTAEGYGFKQEYESF-----FEG--WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNA-DYINANYIDGYHRSNHFIATQGPK
| | .. .|. .... .  ||..|.|.       .    ....|..  .  |.  . |||| ||||.|. |  .  |||||||||||..|. ||||||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALERRGY------SARHEVRQFHFTAWPEHGVPY
.. . |||||.|... . |||||.||| || || .|||.| | ||| ... |...|.|| | |||. .. .           ..|||.|.| ||.|||| 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFK
|..  | |... .|... .|||||.|||||.|||| ||||| .|   . | .|.... .|.. ..| ...||||||||.|||.||| . .|| .  .. .
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

A
.
e
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 874-1164 2.2e-88 291.4 In-house 4-302 (305) alignment 
Range on Protein: 874-1164
Range on HMM: 4-302/305.0
VRVADLLQHINQMKTAEGYGFKQEYESFFE---GWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVY
. ..|| ..|..... .  |....|.|. |     | .||. ... .|.. .  .| .|..| .   ....|||||.|.|||.|....|..||| .. | 
ialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDT---YGDIKIMLVKTETLAEYVVRTFALER-RGYSARHEVRQFHFTAWPEHGVPYHATGLLAF
||||....|. |.|||.||||| |. || .||||       .|.....|  ..| ..|. | . .   .. .  . | |...| ||.||||  || || .
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

IRRVKASTPPDAG-PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM
|.||. .   | | |...||||| |||| .|..|..|. .. |.|||... .|.| |.|..|.|| .|| |.|||. |   ||.| | .| ..|  . .
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl
subfamily_PTPRA_pd Subfamily PTPRA 870-1180 3.5e-88 290.6 In-house 10-330 (330) alignment 
Range on Protein: 870-1180
Range on HMM: 10-330/330.0
LHPAVRVADLLQHINQMKTAEGYGFKQEYESFFE-----GWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGP
 .. . | .| . |.. .. .   |..|....         ....|..  . .|   .  ||  || | .. | ...||||| .||||.. ..|||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSA----RHEVRQFHFTAWPEHGVPYH
| | | |||||.|. . ..|||.|.| |  . || .|||.. . |||.|.. . ... | .| || | ... . ..       |||||||.||. ||| .
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA
. |.| ....||.  .  |||||.|||||.|||| .|||| .|.. ..|..||... || |  .| .|.||.||| ||. ..||  | |.| . || .. 
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

TYKEMIRIDPQSNSSQLREEF
  ...    .. .   | |||
hlqklynkitgtdkigleeef
0046845 (Phosphotyrosine protein) phosphatases II 898-1152 8.2e-88 289.7 In-house 6-281 (284) alignment 
Range on Protein: 898-1152
Range on HMM: 6-281/284.0
YESFF-------EGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGD-PNADYINANYIDGY-----HRSNHFIATQGPKPEMVYDFWRMVWQEHCSSI
.|            .......  ..  |    ..||. ||||... || .. |||||.|.|||     .....|||||||.|. |.|||||||..... |
feellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvI

VMITKLVEVGRVKCSRYWPED--SDTYGDIKIMLVKTETLAEYVVRTFALERRG-YSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP--PDAG
||.|.||| ||.||..|||..  . ||||... |...|.   |.|||. |.. |  .  ..|..||.|.||.|||| ... ||.|.| |. . .  |. |
VmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpggg

PIVIHCSAGTGRTGCYIVLDVMLDMAECEG---VVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTI
|||.||||| ||||..|.||..|.. | ||   .||....|| |...| .|.||.|||.|...|.||..... | .
pivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0043336 (Phosphotyrosine protein) phosphatases II 874-1143 1.3e-87 289.0 In-house 2-275 (278) alignment 
Range on Protein: 874-1143
Range on HMM: 2-275/278.0
VRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMV
..| |||....... .. .....|.|.. .     .. ..... ..  |    ..||..||||... ||.. |||||.|.|||.....||||||| || |
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

YDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR
.|||||||......|||.|.||| ||||| .|||..| ||||... |.|.|.|. |.|||. ....|..  ..|...|...||.||||.. . || |...
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
|.   ... ||...||||| ||||..|.|...|...| || ||....||.| ..| ...||..||.|...|.||
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 871-1180 9.6e-87 285.8 In-house 3-314 (315) alignment 
Range on Protein: 871-1180
Range on HMM: 3-314/315.0
HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKP
|  . . .|. .. | |..   ||||.|||   |     | .||   ..  |   . |||. ||.|  .  ||..||.|||.|||| . ...||.|||..
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

EMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRgySARHEVRQFHFTAWPEHGVPYHATGLLAF
. | ||||.|..|... |||.|.|||  . |. .|||..  .|| | . ... |   || |||..   .  .  .|| |.|.|.||. ||| ... |. .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnl

IRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR
||.||     ..|.||.||||| |||| .| || .|| || | ..|.|| .. . . |..|.|. ||| ||.||.||. .||.|.|    .   |. .. 
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydslla

IDPQSNSSQLREEF
  |.. |. |.|.|
pspdtgstllqeqf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 889-1152 2.1e-86 284.9 In-house 24-297 (298) alignment 
Range on Protein: 889-1152
Range on HMM: 24-297/298.0
AEGYGFKQEYESFF--------EGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEH
 .  |...|.. .         | .....|..  |  |   . |.|  || |. . .| ..||||| ....|...| |||||.| .| | ||||||..|.
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteed

CSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAsTPPDAG
 ..|||.|.|.|....|...|||.  ..|||.|.. | ..|. |...||.......  . ..||||.||| ||..||| .|| .|...|.|.| .. .||
igtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag

--PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTI
  |....||||.||.| .|..| .|. .. | |||... ||.|  .|....||||||.||..|.|||  .... |
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045450 (Phosphotyrosine protein) phosphatases II 870-1146 4.4e-85 281.4 In-house 5-305 (307) alignment 
Range on Protein: 870-1146
Range on HMM: 5-305/307.0
LHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWD-------ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGD-PNADYINANYI--------DGYH
|.. ... .||.......    .|...|.|.... ..       .....   .  |    ..||..||||... |. .. |||||.|.        |||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

RSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED--SDTYGDIKIMLVKTETLAEYVVRTFALERR-GYSARHEVRQFHFTA
....|||||||.|| |.|||||.|..... |||.|.||| ||.|| .|||..  . |||.... |...|.|..|.|||. ...  | .  ..|..||.|.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPEHGVPYHATGLLAFIRRVKA--STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
||.|||| .   ||.||..|..  .. |. ||...||||| ||||..|....||.. | ||.   ||....||.| ..| ...|..|||.|...|.|| .
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

L
|
l
0039614 (Phosphotyrosine protein) phosphatases II 883-1149 8.6e-85 280.0 In-house 23-293 (297) alignment 
Range on Protein: 883-1149
Range on HMM: 23-293/297.0
INQMKTAEGYGFKQEYESF----FEgWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLG-DPNADYINANYIDGYHR-SNHFIATQGPKPEMVYDFWRMV
.  .|  . .....|.|.      . .  ....  ..  |    ..||..||||.|. | |.. |||||.|.|||.. ...||||||| || |.||||||
lllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQEHCSSIVMITKLVEVGRvKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERrgYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-
|......|||.||||| || || .||||...||||... |.|.|.|. |.|||. ...  ..  ..|..|..| ||.|||| ... || |.. |.     
weqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealae

-PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGE
 |. ||...||||| ||||..|... ||.. |.|| ||....||.| ..| ...||..||.|..||.|| .... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 894-1144 1.5e-84 279.0 In-house 14-271 (273) alignment 
Range on Protein: 894-1144
Range on HMM: 14-271/273.0
FKQEYESFFE-----GWDATKKKDKVKGSRQEPMPAYDRHRVKLhpmlGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMIT
...|.| ...      . ......  .  |    ..||. ||||    ||.. |||||.|.|||.....|||||||.|. |.|||||||..... |||.|
lleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

KLVEVGRVKCSRYWPEDSD----TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP--DAGPIV
.||| ||.|| .|||.. .    |||.... |...|| . |.|||. |.. |..  ..|..||.| ||.|||| . . || ||. |.       . ||.|
elvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvv

IHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
.||||| ||||..|.||..||. |.|| ||....|| |.|.| .|.||.|||.|...|.|| 
VHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 917-1143 1.1e-80 265.8 Pfam-A 5-235 (235) alignment 
Range on Protein: 917-1143
Range on HMM: 5-235/235.0
SRQEPMPAYDRHRVKLhpmLGDPN-ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP---EDSDTYGDI
 | . ...||. ||||    |...  |||||||..||.....||||||| .. . |||||||||....|||.|.|.| ||.||..|||   |.| |||||
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

KIMLV-KTE-TLAEYVVRTFALERRGYS-ARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEG
|. |. |..   .||..|.. |. .. . ...||.|.|.|.||.|||| ....|| .||.|. |. .. ||.|.|||||.||||....||..|...| |.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

VVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
 ||....||.| ..| .|.|..|||||...||||
evdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 917-1143 1.1e-80 265.8 In-house 5-235 (235) alignment 
Range on Protein: 917-1143
Range on HMM: 5-235/235.0
SRQEPMPAYDRHRVKLhpmLGDPN-ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP---EDSDTYGDI
 | . ...||. ||||    |...  |||||||..||.....||||||| .. . |||||||||....|||.|.|.| ||.||..|||   |.| |||||
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

KIMLV-KTE-TLAEYVVRTFALERRGYS-ARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEG
|. |. |..   .||..|.. |. .. . ...||.|.|.|.||.|||| ....|| .||.|. |. .. ||.|.|||||.||||....||..|...| |.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

VVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
 ||....||.| ..| .|.|..|||||...||||
evdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 910-1147 2.9e-80 264.1 In-house 6-244 (250) alignment 
Range on Protein: 910-1147
Range on HMM: 6-244/250.0
KKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVkCSRYWP-EDSDT
| .  .  |   . |.|  || |..  || ..||||| ...||. .. ||||||| .. . ||||||..|. ..|||.|.|.| ... ...||| | ...
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP-DAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC
|||... | ..|. |.|..|.. | ..  . .  |||.||..||. ||| .||  |.....|.|| .  ...|....||||.||.|..|..| .|. .. 
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC
| |||... .|.|   |.......|||.|.. .||.|  .
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
DSPc_SM00195 907-1144 5.5e-80 263.8 In-house 20-261 (263) alignment 
Range on Protein: 907-1144
Range on HMM: 20-261/263.0
ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-
 ..|| ...  | . .. ||. ||||..  .... ||||||||.|.......||||||.|. | |||||||.|... |||.|. .| |. ||.|||||. 
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--SDTYGDIKIMLVKTETLA-EYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVML
  . |.|.|.. ||..|.   |...||. |.  | .  ..|.|.....||.|||| ... .|...| || |.    ||||.||||| ||||.....|..|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
.  | |  ||| ..|| | . | .|.||.|||.||..||||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 907-1144 5.5e-80 263.8 In-house 20-261 (263) alignment 
Range on Protein: 907-1144
Range on HMM: 20-261/263.0
ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-
 ..|| ...  | . .. ||. ||||..  .... ||||||||.|.......||||||.|. | |||||||.|... |||.|. .| |. ||.|||||. 
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees

--SDTYGDIKIMLVKTETLA-EYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVML
  . |.|.|.. ||..|.   |...||. |.  | .  ..|.|.....||.|||| ... .|...| || |.    ||||.||||| ||||.....|..|
ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
.  | |  ||| ..|| | . | .|.||.|||.||..||||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 880-1143 7.3e-80 263.1 In-house 9-277 (288) alignment 
Range on Protein: 880-1143
Range on HMM: 9-277/288.0
LQHINQMKTAEGYGFKQEYESF--FEGWDATKKKDK---VKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWR
........  .  ||..||.|   .|  .....  .    |  | . . .|| .||||. .   ..||||||.||||.......|||||| .. | |||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD--TYGDIKIMLVKTETLAEYVVRTFALERRgySARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA
.|.... | |||.|.||| |. || .|||.. .   ||.....||....| ..|.|.. ||..    . |. |....|||.||||  .. ||...| || 
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvkv

STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
. . |.|||..||||| |||| .|.|| ..|. | | ..|. . |. |  .| ...||..||.||....|.
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 879-1144 1.5e-79 262.0 In-house 2-275 (281) alignment 
Range on Protein: 879-1144
Range on HMM: 2-275/281.0
LLQHINQMKTAEGYGFKQEYESFFE-GW----DATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFW
| .|..|... .  ||..|||.. . |      |.|... |.  |   . |||  |||..|   . |.||||||...||.  ...|||||| |. ...||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS--DTYGDIKIMLVKTETLAEYVVRTFALERRGYSARhEVRQFHFTAWPEHGVPYHATGLLAFIRRVK
.|||... | |||.|. .| |..|| ||||.|.   .|||...  ...|. |.|. |.| |||..  .| ||.|...||||.||||  .. || | . |.
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetr.eveqlaytaWPdhGvPattkellefrkevl

-ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECE-GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
 ....    |.||||||| ||||.|| || ... .| |   .|. . |. |  .|  |.||  || |.. |.|.|
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
0050432 (Phosphotyrosine protein) phosphatases II 1140-1441 1.7e-79 262.7 In-house 7-300 (308) alignment 
Range on Protein: 1140-1441
Range on HMM: 7-300/308.0
AILEACLCGETTIPVSEFKATYKEMIR-IDPQSNSSQLREEFQTLNSVTPpldVEECSIALLPRNRDKNRSMDVLPPDRCLPFListdGDSNNYINAALT
|.||..|...|.|.|| .| ....... .... ....|.|||..|.||.|   ..|.|.||||.|.||||..|.|| |..  .|    .....|||| . 
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyv

DSY--TRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPEP---GRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEgh
| |   .. .||.| .||..|. ||||.|...... ||||..| . |. . | ||||.    | ..|| . |...| . ..| . |.....|..  ..  
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges..

LLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQaesGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCY
. |.||... |    ..|.| ...|..| .|.|..   ..| ..||| .| ||.|||.|. ..||...... |||| | |.|| ..|.||.| .||.|.|
rtvthfhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfly

DVALEYLE
...||||.
ralleylk
subfamily_Ptp69D_pd Subfamily Ptp69D 872-1164 1.6e-78 258.9 In-house 2-305 (307) alignment 
Range on Protein: 872-1164
Range on HMM: 2-305/307.0
PAVRVADLLQHINQMKTAEGYGFKQEYESFF-----EGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKP
.|. . || . ... |    .|...|||.           ...||.     | | . |.|..||||... |. ..|||||..| ||. ...||| |.|  
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

EMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALERRG-----YSARHEVRQFHFTAWPEHGVPYHA
. . |||||... .   |||...| |  | ||..||| ||   |||| . ||..|.  .|. |.. . . .       ....| |.|.|.|..  || .|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT
.||| .|..|.     . .|||.|||||.||.| .. ||..|.  . |  |||.. || | |.|  ..|  |||.|.. |.|.    |.| . | ... .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

YKEM
....
ierl
0051299 (Phosphotyrosine protein) phosphatases II 1148-1440 4.6e-78 257.9 In-house 1-286 (288) alignment 
Range on Protein: 1148-1440
Range on HMM: 1-286/288.0
GETTIPVSEFKATYKEMIridpQSNSSQLREEFQTLNSVTPPldvEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAA
|.| |.|.|.  ......    ... ..|.|||..| |..|.    ..|.|||| |..|||..|.|| |..  .| ..|| ....|||| . | | .. .
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNI--SRLQEGHLLVRHFQFLRW
||.| .||..|. ||||.|...... ||||..|   .. . | ||||. | ..|| . |...| . ..| . |...|.|.   . .. .. |.||... |
fIatqgPlpntvedFWrmvweqnvrvIvmltklve.lgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnw

SaYRDTPDSKKAFLHLLAEVDKWQAeSGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
    ..||| ...|..| .|.|..| ||.| ..||| .| ||.|||.|. ..||...... |||. | |.||...|.||.| .|| |.|...||||
p.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 909-1146 9.7e-78 256.5 In-house 7-247 (249) alignment 
Range on Protein: 909-1146
Range on HMM: 7-247/249.0
KKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSD
...  ..  |    ..||..||||... | .  |||||.|||||.....||||||| ||.|.|||||.|......|||.|.||| ||.|| .||| ..| 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA--STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA
.|||... |...|....|.|||. |.. ...  ..|.....| ||.|||| .   ||.||..|.   .. |. ||...||||| ||||..|... ||.. 
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL
| |. ||....||.| |.| ...|..|||.|...|.|| .|
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 923-1189 1.2e-77 256.2 In-house 53-320 (515) alignment 
Range on Protein: 923-1189
Range on HMM: 53-320/515.0
PAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE---DSDTYGDIKIMLVKT
  ||. ||||  .  .|. ||.|| || ...  . .||.|||..  | ||||.|.||. . |.|.||| |  ..||..|||.   ||  .| ||. || .
lPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsl

ETLAEYVVRTFALERRGYsaRHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKT
|. .. . |.. . .      . | ||||| ||..||| |.. || .|. |||..   . |..|||||| |||| .| .| ..  |.   .||..| |. 
eactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtn

LCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP
.  .|. ..||.||| ||..|.||  |  .| |||  |    ...         |.. .|||||.|..| 
irqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 918-1164 1.9e-76 252.4 In-house 66-310 (319) alignment 
Range on Protein: 918-1164
Range on HMM: 66-310/319.0
RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITklvevgRVKCSRYWPEDSD-TYGDIKIML
|   . |.|. .|||... |   .||||| ...|| | . .||.|||... . |||||.|. .||.||..|      . |||.||| . . ...  |. .
riinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv

VKTETLAEYVVRTFALERRGY-SARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP--PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDI
   |  |||||| . | . |      ...||||  ||..||| ... |. ....|.  |    .  .||.|||||.|||| ||||||.||. . |  ||.
dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdv

YNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM
|| |. |  .| ...|   || ||. |.||  | | . . . .| | ..|.
ynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 910-1183 8.5e-76 249.8 In-house 41-315 (315) alignment 
Range on Protein: 910-1183
Range on HMM: 41-315/315.0
KKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE---DS
...  |  | . .  .|. ||||  .  .|. ||||| || ...  . .||.|||..  | ||||||.||. ..|||.||. |  ..|| .|||.   ||
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

DTYGDIKIMLVKTETLAEYVVRTFaLERRGySARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE
  .| ||. |...|. .. |.| .   |..  . . | ||.|| ||..||. ... || .|. |||.  ..  ....|||||.||||  | .| ... ..
vefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqik

CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTL
 . .||..| ||.| . |. ..||||.| ||.||.||  |  .| |.|  |    ...      |  |.. .||.||
rtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 918-1164 1.2e-75 249.7 In-house 30-274 (284) alignment 
Range on Protein: 918-1164
Range on HMM: 30-274/284.0
RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITklvevgRVKCSRYWPEDSD-TYGDIKIML
|   . |.|. .|||... |   .||||| .| || | . .||||||... . |||||.|. .||.||..|      . |||.||| . . ...  |. .
righilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv

VKTETLAEYVVRTFALERRGY-SARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP--PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDI
   |  .||||| . | . |      ..|||||  ||..||| ... |......|.  |    .  .||.|||||.|||| ||||||.||. . |  ||.
dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdv

YNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM
|| |. |  .| ...|   || ||. |.||  | | . . . .| | ..|.
ynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0042113 (Phosphotyrosine protein) phosphatases II 909-1143 1.4e-75 249.1 In-house 5-241 (245) alignment 
Range on Protein: 909-1143
Range on HMM: 5-241/245.0
KKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSD
...  ..  | .. ..||. |||| |. ||.  |||||.|.|||.....||||||| || | |||||.|......|||.|...| ||||| .||| ..| 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE
||||... |...|.|..|.|||. ... |..  .||...|.. ||.|||| .   || |...|.     .. ||...||||| ||||..|... ||...|
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
 |. |.....|| | |.| ...||..||.|...|.||
kelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1148-1441 1.2e-73 243.0 In-house 1-291 (298) alignment 
Range on Protein: 1148-1441
Range on HMM: 1-291/298.0
GETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAA
|.| | ....||. ...  .... . ... .|||.||||.  .. || ..|  |.|..||| .|... | .   | ..|.|   .||||.  ..|... |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLqeGHLLVRHFQFLRWSA
||.| .||..|. ||||.| ..  ..||||..|....    . .|||. | ..|| ..|. .|     ||. | . |.. ..   ..  ||...|  |. 
fiatqaPltetvedFWrmvteedigtiVmltnleeldkt.kyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd

yRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 ...|  ... |.||..| ..| ..|.   ||.| .| ||||||.|  .||| ..  . |||| . |.||. .|..|.| .|| |.|.. ||.|.
.kgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
0045098 (Phosphotyrosine protein) phosphatases II 915-1148 6.3e-73 240.8 In-house 35-275 (278) alignment 
Range on Protein: 915-1148
Range on HMM: 35-275/278.0
KGSRQEPMPAYDRHRVKlhpmlgdpnaDYINANYIDGYhrSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS-DTYGDIK
.  |    ..||. |||          |||||.|||||  ...|||||||.|. | |||||.|......|||.|.||| ||.|| .||||..  ||||..
dknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

IMLVKTETLAEYVVRTFALERR----GYSARHEVRQFHFTAWPEHGVPYHA--TGLLAFIRRVKASTP-------------PDAGPIVIHCSAGTGRTGC
. |...|.| .|..||. ..       .   ..|...|.. ||.|||| .   . .| .......                .. ||...||||| ||||.
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

YIVLDVMLDMAecEGVVDIYNCVKTLCSRRVN-MIQTEEQYIFIHDAILEACLCG
..... ||..   ||.||....||.| |.| . ..|..|||.|.....||  |.|
lvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0039614 (Phosphotyrosine protein) phosphatases II 1164-1440 1e-72 240.4 In-house 22-289 (297) alignment 
Range on Protein: 1164-1440
Range on HMM: 22-289/297.0
MIRIDPQSNSSQLREEFQTLNSVTPPldveeCSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG--DSNNYINAALTDSYTR-SAAFIVTLHPLQSTTPD
............|..||..| |..|.     .|||||| |.||||..|.|| |..   | . ||   ...|||| . | | . . .||.| .||..|. |
llllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWRLVYDYGCTSIVMLNQLNQSNSawPCLQYWPEPGRqQYGLMEVEFMSGTADEDLVARVFRVQNisrlQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHL
|||.|...|.|.||||..|.  .    | ||||| |  .|| . |.... . ... . |...|.|     .  . |.|||.. |    ..|.| . .|..
FwrmvweqgvtvivmLtklvelgr..kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwp.dhgvppslelllef

LAEVDKWQAES-GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
| .|....||. ..|...||| .| ||.|||.|. ..||.....  |||. | |.||...|..|.|..||.|.||..||.|
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0047943 (Phosphotyrosine protein) phosphatases II 1165-1440 9.7e-72 237.0 In-house 3-272 (273) alignment 
Range on Protein: 1165-1440
Range on HMM: 3-272/273.0
IRIDPQSNSSQLREEFQTLNSVTPpldVEECSIALLPRNRDKNRSMDVLPPDRCLPFListDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL
...........|.|||..| |..|   . ..|.||||.|.||||..|.|| |..  .|   ......|||| . | | .. .||.| .||..|. ||||.
lllekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VYDYGCTSIVMLNQLNQsNSAWPCLQYWPEPG---RQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQegHLLVRHFQFLRWSaYRDTPDSKKAFLHLL
|...... ||||..| . .. . | ||||. |    ..|| . |...| . ..| . |.....|..  .   . |.||... |    ..|.| . .|...
vweqnvrviVmLtelve.lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwp.dhgvppslesllefi

AEVDKWQAES-GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .|.|..... ..| ..||| .| ||.|||.|. ..|....... |||. | | ||...|.||.| .|| |.|...||||
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN9_pd Subfamily PTPN9 878-1145 1.3e-71 236.1 In-house 5-290 (297) alignment 
Range on Protein: 878-1145
Range on HMM: 5-290/297.0
DLLQHINQMKTAegyGFKQEYESF-----FEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDF
.|........     | ..||.           .|.|..  ..  | . .  ||. ||.|  . .|...||||||..|||.. . ||||||| .. | ||
elvayvkekgkr...GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMVWQEHCSSIVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR
|||||....  |||.|..|| ||.||..|||   |.|. .||...  |..|.  .|.||.. ...   .   .|  | |..||..|||  |. || ... 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VKA-------------STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
|.                .|.  |||.||||| |||| .| ||. |.  | .|.||. ..||.| ..|  .|||.||| | . |.||  
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0046845 (Phosphotyrosine protein) phosphatases II 1175-1441 1.6e-71 236.3 In-house 1-275 (284) alignment 
Range on Protein: 1175-1441
Range on HMM: 1-275/284.0
QLREEFQTLNSVTPPLDvEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG--DSNNYINAALTDSY-----TRSAAFIVTLHPLQSTTPDFWRLVYD
.|.|||..|.|.|..|   ..|.|||| |..|||..|.|| |..  .| |.||  ....|||| . | |      .. .||.| .||..|. ||||.|..
gleeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

YGCTSIVMLNQLNQsNSAWPCLQYWPEPG-RQQYGLMEVEFMSGTADEDLVARVFRVQNIsRLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDK
.... ||||..| . |. . | ||||. |  ..|| . |...| . ..| . |.....|.  . . .. |.||... |   ...|.| . .|..| .|..
qnvrvIVmltelve.ngrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswp.dhgvppspedlleflrlvre

WQAE-SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHN---LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
.. . .|.| ..||| .| ||.|||.|. ..||... ..    |||. | | ||...|.||.| .|| |.|...|||| 
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0036941 (Phosphotyrosine protein) phosphatases II 1165-1441 2.1e-71 236.0 In-house 4-278 (297) alignment 
Range on Protein: 1165-1441
Range on HMM: 4-278/297.0
IRIDPQSNSSQLREEFQTLnsvTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFListDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL
...........|..||..|   .| |   ..|.||||.|..|||..|.|| |..   |   |.....|||| . | | .. .||.| .||..|. ||||.
kllekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VYDYGCTSIVMLNQLNQsNSAWPCLQYWPEP--GRQQYGLMEVEFMSGTA--DEDLVARVFRVQNIsrLQEGHLLVRHFQFLRWSAYrDTPDSKKAFLHL
|.....|.||||..| . .  . | ||||.   . ..|| . |...| .   ..| . |...|...    . .. |.||... |  . ..|.| . .|..
vweqnvtvIvmltelve.lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdh.gvpespaslldf

LAEVDKWQAES-GDGRTIVHCLNGGGRSGTFCACATVLEMIR---CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
. .|.|..... ..|...||| .| ||||||.|. ..|....    .. ||.. | |.||...|..|.| .||.|.|.. ||.| 
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 916-1143 3.4e-70 231.6 In-house 13-240 (243) alignment 
Range on Protein: 916-1143
Range on HMM: 13-240/243.0
GSRQEPMPAYDRHRVKLhpmlgdPNADYINANYIDGYhrsNHFIATQGPKPEMVYD----FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPeDSDTYGD
  |    ..||. ||||      .. ||||||.|...   ...|||||| ||.| |    ||||.|......|||.|.||| ||.|| .||| .. ||||
knrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gevtygd

IKIMLVKTETLAEYVVRTFALERRG-YSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAS--------TPPDAGPIVIHCSAGTGRTGCYIVLDVML
... |...|.|..|.|||. ||. . .   ..|...|...||.|||| . . ||.|.. |..         . .. ||...||||| ||||..|....||
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

DMAeceGvVDIYNCVKTLCSRRVN-MIQTEEQYIFIHDAILE
..    | ||....||.| ..| . ..||..||.|...|.||
lll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 890-1142 3.6e-70 231.4 In-house 24-294 (306) alignment 
Range on Protein: 890-1142
Range on HMM: 24-294/306.0
EGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPaYDRHRVKLHpMLGDPNADYINANYIDGYH--RSNHFIATQGPKPEMVYDFWRMVWQE
|  ||..|.|..        ..  ...|.. | |   .  .| .|  ||.|.   . |..||||||||..     ....|||||  .. | |||||||||
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilP.fDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

HCSSIVMITKLVEVGRVKCSRYWPEDS--DTYGDIKIMLVKTETLAEYVVRTFALE-RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-
..  |||.|| || |. ||.||||. .  ..||.|... |. ..||.|..|.. .. ..  .  .||.|.||..||.|||| .   .|.|.. |.. .  
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

---PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
    .|||||.||||| |||| .||.|..|.. | .|.   .||...||.. . |  ..|||.|| |.. || 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0040438 (Phosphotyrosine protein) phosphatases II 1170-1440 8.2e-70 230.9 In-house 14-276 (317) alignment 
Range on Protein: 1170-1440
Range on HMM: 14-276/317.0
QSNSSQLREEFQTLNSVTPPldveECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDY
.|.  .|.|||..| |....    ..|.|.|| |.||||..|.|| |..   | ...|  ...|||| . | . .. .||.| .||..|. ||||.|...
ksdftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq

GCTSIVMLNQLNQsNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIsrLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQ
|.|.||||..| . .. . | ||||. . ..|| . |...| . ... . |...|..     . .. |.||... |    ..|.| . .|..| .|....
gvtvivmLtelee.lgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWp.dhgvppspdllldfleavreal

AeSGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
. ...| ..||| .| ||.|||.|. ..||... .. |||. | |.||...|..|.| .||.|.||..||||
e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 1161-1440 3.5e-69 229.2 In-house 14-304 (307) alignment 
Range on Protein: 1161-1440
Range on HMM: 14-304/307.0
YKEMIRIDPQSNSSQLREEFQTLNSVTPPLdVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG--DSNNYINAALT--------DSYTRSAAFIVT
.  ......... . |..||..|.|||..| . |.|||||| |.||||..|.|| |..   | |.||  ....||||           |.| .. .||.|
llllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

LHPLQSTTPDFWRLVYDYGCTSIVMLNQLNqSNSAWPCLQYWPEPGRQ-QYGLMEVEFMSGTADEDLVARVFRVQNIsRLQEGHLLVRHFQFLRWSaYRD
 .||..|  ||||.....|.| ||||..|   .  . | ||||. | . .|| . |...| . ..... |...|..  .  . .. |.||....|    .
qgPlpetvedFwrmlweqgvtvivmltelv.elgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwp.dhg

TPDSKKAFLHLLAEVDKWQAES-GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNL---VDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.|.| . .|... ||.|...|. ..|...|||  | ||.|||.|. ..|.... ..    ||.. | |.||. .|..|.. .||.|.|...||.|
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 901-1145 3.7e-68 224.5 In-house 29-277 (290) alignment 
Range on Protein: 901-1145
Range on HMM: 29-277/290.0
FFEGWDATKKKDKvKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSR
 ..   ..|.... |  |   .  ||  ||.|. . .... ||||||.| | . . ..||.||| |. . |||||.|. . . .||. ..||.|. || |
vysteagekeenv.kknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPED--SD-TYGDIKIMLVKTETLA-EYVVRTFALERRgySARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI
||||   .. ..|.... | . ...  ....||...|..  .....|.|||.||||.||||  |. ||..|. |.     .. |.|.||||| ||||  |
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

VLDVMLDMAECEGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
..| . .. . | .   .|... | .|  .|. ..||.||| ... |..| .
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 909-1144 3.7e-68 224.2 In-house 4-239 (239) alignment 
Range on Protein: 909-1144
Range on HMM: 4-239/239.0
KKKDKVKgSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSN-HFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD
|. .| |  |   . .||. || |  .  || .|||||.|.  |  |   .|||||       |||||.|||.   |||.| |.|  . || .|||. . 
krvnkak.nryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC
 | .... | ||| .|.|..||| . . | .  . | |.||| ||..||| .|| .| . |..   . | | | ||||||| ||||...|.| ||  |. 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
.  |||.| ||..   |  |.|| |||.||| |.|||
qktvdifnyvkairedrphmvqtseqyvfihlavlea
0043336 (Phosphotyrosine protein) phosphatases II 1164-1440 8.3e-68 224.2 In-house 10-277 (278) alignment 
Range on Protein: 1164-1440
Range on HMM: 10-277/278.0
MIRIDPQSNSSQLREEFQTLNSVTPpldvEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFW
...    .. . |..||..|.|...    ...|||||| |.||||..|.|| |...  | ...||  ..|||| . | | .. .||.| .||..|. |||
allelllnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPePGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEghLLVRHFQFLRWSaYRDTPDSKKAFLHLLA
|.|...|.|.||||..|   .. . | ||||  | ..|| . |.... . ..| . |...| |    ..  . |.|...| |    ..|.| . .|..| 
rmvwelgvttivmLtelve.lgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwp.dhgvpeslsllldflk

EVDKWQAeSGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.|..... . .| ..||| .| ||.|||.|. ..||... .  ||.. | |.||...|..|.| .||.|.|...||||
avreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 907-1143 1.1e-67 222.7 In-house 2-239 (239) alignment 
Range on Protein: 907-1143
Range on HMM: 2-239/239.0
ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSN-HFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED
|.||. .    |   . .||. || |  .  || .|||||.|.  |  |   .|||||       |||||.|||.   |||.| |.|  . || .|||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA
.  | .... | ||| .|.|..||| . . | .  . | |.||| ||..||| .|| .| . |..   . | | | ||||||| ||||...|.| ||  |
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
. .  |||.| ||..   |  |.|| |||.||| |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN3_pd Subfamily PTPN3 907-1144 3.6e-66 217.9 In-house 35-274 (280) alignment 
Range on Protein: 907-1144
Range on HMM: 35-274/280.0
ATKKKDKVKGSRQEPMPAYDRHRVKLHpmlgDPNADYINANYID----GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW
|..| . ..  |   . .||  ||||.    . ..|||||||..    . . .|..|||||| .. . |||.|||....| |||.| ||| ||||| .||
aarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PEDSD--TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV
|| .|  .||...... |...  .||.| . |...  . .... |. ..|||.|||| ... .| |..||..    .  |.|.||||| |||| .|.|..
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
 | . |..  | . . |.|.  .| ...||..|| |. .|||..
alalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPRD_pd Subfamily PTPRD 1201-1441 1.8e-65 216.7 In-house 46-282 (564) alignment 
Range on Protein: 1201-1441
Range on HMM: 46-282/564.0
PRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQQ
| |. |||  .... |..   | ...|| . .||||   |.|... |.| | .||..|. ||||.|... ...||||..|. ..    | .|||| |...
paNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv.kchkYWPekgtet

YGLMEVEFMSGTADEDLVARVFRVQNISRLQEghLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQaESGDGRTIVHCLNGGGRSGTFCACATVLEM
|| ..|.... .  .| . | |.... .. .     ||.|.|  |   .. |.| ...|.|. .| ... |.. | ..||| .| ||.|||..   .|| 
ygeltVtleeeeeladyeirtfklkkkksses..reVrqFhFtsWPd.hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamler

IRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
|.  ..||..   |.||. .. ||.| .||.|.... ||.|.
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 873-1181 6e-65 214.5 In-house 4-324 (325) alignment 
Range on Protein: 873-1181
Range on HMM: 4-324/325.0
AVRVADLLQHINQMKTAEGYGFKQEYESFFE----GWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEM
.. | .|..|... |. .  || .|..           .. | . ..  | . . |.|. || |  .  ||..|||||.|.  . . . |.|.| |... 
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

VYDFWRMV--WQehcSSIVMITKLVEVGRVKCSRYWPED---SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGL
. |.||.|  |.   .|.|...  .. |  .|. |||..   | |.| ... |.  |....|| | . . .        |.||.. .|.. ||. . . |
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatl

LAFIRRVKAST------PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEF
..... |||           ..||..||||| |||| .| |  .|.    |  |||.. || |   | .|..| .|||.|..|. || ..|.| .||| |
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf

KATYKEMIRIDPQSNSSQLREEFQ
.|    .   .| ..  .. .||.
eaklsslqernpltqklniekefe
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 882-1146 1.2e-64 213.0 In-house 10-284 (290) alignment 
Range on Protein: 882-1146
Range on HMM: 10-284/290.0
HINQMKTAEGYGFKQEYESFFEGWDATK-----KKDKVKGSRQEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWR
.. . ..    ||.......  |    .      ..  .  |.. .  || .|. |.|. |...   .|||| ||.||. ....|||||| .. . |||.
fvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALERRGY-SARHEVRQFHFTAWPEHG-VPYHATGLLAFIRRVK
..|||... |||.|. .| |.|||  |||.  ...|| ..| |.. ||| ||. |.. .. .    |...| |...|.|...| |. ..| ||.. ...|
liwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL
    .  ..||.|||.. ||.. ...... .. .. |||.|... .|.. . . ...||..|| .|.. .|..  
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 917-1143 1.3e-64 212.7 In-house 7-237 (237) alignment 
Range on Protein: 917-1143
Range on HMM: 7-237/237.0
SRQEPMPAYDRHRVKLHPMLGDpnADYINANYIDGYHRS-NHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED--SDTYGDIK
.|   . |||  || |.   ..  .|||||.|..|.  . ...||.|||      |||.|||||.|| |||.| |.|  ..|| .|||.     .|| . 
nrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

IMLVKTETLAEYVVRTFALERRGYSAR-HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP--PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGV
. | | | ...| ||.. | .|.       . |..||.||..||| ... || | ...   .|  ...|| .|||||| |||| ..|.| ||  |. . |
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkv

VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
||||| |...   |  .|||..||.|||..|||
vdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-1157 1.4e-64 213.0 In-house 43-296 (297) alignment 
Range on Protein: 907-1157
Range on HMM: 43-296/297.0
AT--KKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRsnHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRvKCSRYWPE
.|  .|| . . || . .  ||. ||||. .  ||..||.|| .. |..   ..|.|| |... | |||.||..|. | |||.... |  . || |||..
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

DS-DTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY--HATGLLAFIRRVKASTPPDAG-PIVIHCSAGTGRTGCYIVLDV
..  |.||. ..|  ..    .. |.. ...    ||. |.|..|. ||.. |.   .|. || .|  |. .    |  |...||.|| |||| .. .| 
kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEF
..  |. |  |||.. || |   |....||.||| |.. |.||| |. .| |..| |
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 917-1161 1.1e-63 210.2 In-house 52-295 (439) alignment 
Range on Protein: 917-1161
Range on HMM: 52-295/439.0
SRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRvkcsrYWPEDSDTY-GDIKIM
 | . . |.|  || |. . | | . |||||||.||.  . .||||||| | . ||||.|...... |||.|.|||  .     ||| |.... ||| . 
nrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavr

LVKTETLAEYVVRTFALE--RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAS-TPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD
  .   | .||.| | .   |      . | |||..|||.. || .|. .| |.| ....    . ||.|.||||| ||||  | ||. |.    |  ||
vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvd

IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATY
|   || |  .| .|.|.  ||.||..|.||    |.... . |||  .
ikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
0040439 (Phosphotyrosine protein) phosphatases II 1194-1440 4e-63 208.6 In-house 2-246 (249) alignment 
Range on Protein: 1194-1440
Range on HMM: 2-246/249.0
ECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSnSAWPCLQYW
|.|.|||| |.||||..|.||.|.. . | ...|   ..|||| . | | .. .||.| .||..|..||||.....|.|.||||..| .    ..| |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.grekcaqyw

PEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIsrLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAES-GDGRTIVHCLNGGGRSGTFC
|. | ..|| . |...| .  .|.. |.....|.      .. |.|.|.. |    ..|.| . .| .. .|.|...|   .|...||| .| ||.|||.
plggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

ACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
|. ..||... .. ||.. | |.||...|..|.. .|| |.|...||.|
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 926-1142 4.8e-63 207.8 In-house 41-265 (274) alignment 
Range on Protein: 926-1142
Range on HMM: 41-265/274.0
DRHRVKLHPMLGD-PNADYINANYIDGYHR-SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDT-----YGDIKIMLVK
.. || |..  .. ....||||||| ||.. |. ..||||| |. | |||||..||... |||.||| |  . ||..|.|.. |.     |||..|  .|
ensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvek

TETLAEYVVRTFALERRGYsaRHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP---PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYN
. .  .| ||.. |.      ...|  . .|.||.| .| .|. || ... |. |       ..|.|.||||| |||||.|  .. .   . |.|||. .
iverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlk

CVKTLCSRRVNMIQTEEQYIFIHDAIL
 |  |   |  |.||.||| .|| |. 
ivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 918-1151 6.3e-63 207.4 In-house 52-284 (287) alignment 
Range on Protein: 918-1151
Range on HMM: 52-284/287.0
RQEPMPAYDRHRVKLHpmlgDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS-DTYGDIKIML
| . .  .| .|| |.    . . ||||| .||||. ...||....|  . . .||....... . |||.... |  . .| .||||..  ..|. .|.|
Rltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniel

VKTETLAEYVVRTFALERRG-YSARHEVRQFHFTAWPEHG-VPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIY
.. |. |.|..|.. .....  .....|.|...|.|...| |. ..| || . ...|.   .  ..||.|||.. ||.. ..  .. .. .. |||.|..
lneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvf

NCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETT
. .|    .. ...|| |||.|| |..||   ..|| 
qvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN13_pd Subfamily PTPN13 879-1144 6.4e-63 207.6 In-house 4-268 (273) alignment 
Range on Protein: 879-1144
Range on HMM: 4-268/273.0
LLQHINQMKTAEGYGFKQEYESFFEGwDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGdpnadYINANYIDGYHRS--NHFIATQGPKPEMVYDFWRMV
| ....| . || .   .|  .  .  . .|||.. .  |   .  ||. ||||    |     ||||..|         ..||.||| || | |||.||
lqkkldqqqPaeefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmv

WQEHCSSIVMITKLVEVGRVKCSRYWPEDSD----TYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA
|. ... |.|.|. .| |.||| |||||  .     .. ... |.|.. | ..|||..|..    .. .|| ...|..||.|||| .|. || |...|. 
weqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr

STPpDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
    ||||||.||||| ||.| .|..||.|.. | .  .|. . |..|  .|  ..||..||||.. ||||.
lqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
0045098 (Phosphotyrosine protein) phosphatases II 1174-1442 2.3e-62 206.2 In-house 7-274 (278) alignment 
Range on Protein: 1174-1442
Range on HMM: 7-274/278.0
SQLREEFQTLNSVTPPldvEECSIALLPRNRDKNRSMDVLPPDRCLPFlistdgdsnNYINAALTDSYtrSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
..|. ||. | .  .|    |.. ||.. |.|||| .|.|| |..  .         .|||| . |.|  . .||.| .||.||. ||||.....|.|.|
ldlllefefllllgip...seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvi

VMLNQLNQSNSAwPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGH--LLVRHFQFLRWSAYrDTPDSK--KAFLHLLAEVDKWQA
|||..| . .    | ||||| | ..|| ..|...| .  .| . |...|.|..  .|.   . |.|...| |  . ..|..   | ||.|| .......
vmltelvelgre.kcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealk

------------ESGDGRTIVHCLNGGGRSGTFCACATVLEMIrcHNLVDVFFAAKTLRNYKPN-MVETMDQYHFCYDVALEYLEG
            ....|...|||  | ||.||..|. ..||..  .. ||.. | |.||...|. .|....||.|.|...||.|. 
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 1195-1441 4.3e-62 205.0 In-house 1-244 (245) alignment 
Range on Protein: 1195-1441
Range on HMM: 1-244/245.0
CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWP
.|.|||| |.||||..|.|| |...  | ...||  ..|||| . | | ..  ||.| .||..|..||||.....|.|.||||...   .. . | ||||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee.lgrvkcaqywp

EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNIsrLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCAC
. . ..|| . |...| . ..|.. |...|.|.      .. |.|...| |    ..||. . .| .| .|.|..||...|...|||  | ||.|||.|.
lgesltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

ATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 ..||... .  |... | | ||...|..|.| .||.|.|...||.|.
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_CG7180_pd Subfamily CG7180 1175-1439 5e-62 204.2 In-house 14-289 (296) alignment 
Range on Protein: 1175-1439
Range on HMM: 14-289/296.0
QLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
. | |.. .  .|| |. ..|  .|   ||.|||  .|.|.|   ..| . ||... .||||.  ||... ...|||  | ..|  .||||||| .. ..
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMLNQLNQSNSawPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNI--------SRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVD
|.| .  . .    ...|||. ...||| ..|| ..     .|. | |...             .    .|..||.  |      | | .|...|.  | 
vvLtktfdfak..mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr

KWQAES----GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
.|. .       | ..|.. .|..||| ..|    ||... .. |||| |.||||. .|..||....|...||| ||.
lwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
DSPc_SM00195 1176-1440 9.2e-62 204.1 In-house 2-262 (263) alignment 
Range on Protein: 1176-1440
Range on HMM: 2-262/263.0
LREEFQTLNSVTPPLdveECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIV
|.|||..|.. |.|    |.. |  ..|..|||. ..|| |.    | .... ....||||   . .... ..|.| .||.||  ||||.|.. ... ||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNQLNQSNsAWPCLQYWPEP--GRQQYGLMEVEFMSGTADE-DLVARVFRVQNISRlqEGHLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAES
||.. ....    | .||||   | ...| ..|.... . .. ... |......  .  | .  |...|.  |    ..|||.| .|.|| .|.|.. .|
mlteeeeng.kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

gDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .| ..||| .| ||.|||..  ..|. .. .. ||.|   | ||. .|.||.| .||.|.|...|||.
.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1176-1440 9.2e-62 204.1 In-house 2-262 (263) alignment 
Range on Protein: 1176-1440
Range on HMM: 2-262/263.0
LREEFQTLNSVTPPLdveECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIV
|.|||..|.. |.|    |.. |  ..|..|||. ..|| |.    | .... ....||||   . .... ..|.| .||.||  ||||.|.. ... ||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNQLNQSNsAWPCLQYWPEP--GRQQYGLMEVEFMSGTADE-DLVARVFRVQNISRlqEGHLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAES
||.. ....    | .||||   | ...| ..|.... . .. ... |......  .  | .  |...|.  |    ..|||.| .|.|| .|.|.. .|
mlteeeeng.kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts

gDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .| ..||| .| ||.|||..  ..|. .. .. ||.|   | ||. .|.||.| .||.|.|...|||.
.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_CG7180_pd Subfamily CG7180 921-1150 6.4e-60 197.3 In-house 50-295 (296) alignment 
Range on Protein: 921-1150
Range on HMM: 50-295/296.0
PMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRvKCSRYWPED-SDTYGDIKIMLVKT
 .  ||  || |. . |. . ||||| |.|.. . . .| |..|| | | .|||.|..|..|..|..||  .  . ..  |||..    ||.| . .|..
kvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveivee

ETLAEYVVRTFALERR---------GYSA-RHEVRQFHFTAWPE-HGVPYHATGLLAFIRRVKAS-----TPPDAGPIVIHCSAGTGRTGCYIVLDVMLD
...|. . ||| | ..         . .|    |..|..| |.  . ||. ...|. ..|||.         |. ||.|...| |..|.| |. .|. |.
kqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanle

MAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET
..| |. ||... ||||   | ..... |.| .| | .||| ||. .
lvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1197-1442 7e-60 197.3 In-house 3-244 (250) alignment 
Range on Protein: 1197-1442
Range on HMM: 3-244/250.0
IALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwpCLQYWPEP
.|  |.|..||| .|... | .   | ...||   .||||.  ..|. . |||.| .|||.|. ||||.|...  ..||||..|..|.    . ||||  
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt..yhqywPve

GRQQYGLMEVEFMSGTADEDLVARVFRVQNISRlqEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT
. ..|| . |. .|     |.. |.. . . ..  ... .||...|. |   .  |.  .| |.|| .| . | ..|..  ||.| .| ||||.|.|  .
kaekyGdvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPd.kgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
||| ..  . ||||   |.||. .|..||. .|| |.| ..|..|. 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1151-1442 1.3e-59 196.9 In-house 4-285 (319) alignment 
Range on Protein: 1151-1442
Range on HMM: 4-285/319.0
TIPVSEFKATYKEMIRidpqSNSSQLREEFQTLNSVTPPldveECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIV
 |.| |.|  .|..      . . .|..||..|.  ..     . . |  ..|..|||  ..|. ||.   | . ||  . .||||.  |.| .  .|| 
eievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfia

TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSnSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGhLLVRHFQFLRWSAyRD
|  ||. |. ||||.|.....  .|||..|..      . .||||   ..|| . |.  .    ||.. | . ... |   |    | |||.. |.   |
tqaPlentiedfWrmvWeeessivvmltklvek.lkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpd.hd

TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
 |.. .. |.|| .. | . .. .|  .||| .| || |||..   .|| ..  ...|||  ...||  .. ||.. .||.|.|.. ||..| 
vPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1198-1443 3.9e-59 195.3 In-house 41-283 (318) alignment 
Range on Protein: 1198-1443
Range on HMM: 41-283/318.0
ALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSnSAWPCLQYWPEPG
.| | |. ||| ...|. |..   |  ..|.   .||||   | |.|. |.| .  ||  | .||||.|.. ... |||| |.... .   . .|||. |
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeer.gkakvhryWPskg

RQQYGLMEVEFMSGTADEDLVARVFRVQNisRLQEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATV
 ..|| . || .. .  .|.| | |.|..  . .| .  || ...  |.  ...|.|   .|.|. .|.|.|..|| | ..|||  | || |.|.|  ..
srsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpd.egvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdil

LEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGL
|| |.  .|||||   |.||. .. || | |||.|.||| ||.|.  
lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 927-1144 8.2e-59 193.8 In-house 34-263 (270) alignment 
Range on Protein: 927-1144
Range on HMM: 34-263/270.0
RHRVKLHPMLGDPNADYINANYIDGYHR-SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDT-----YGDIKIMLVKTE
. ||.|...  |... ||||||. |..  ....||..||.|  . .||||.|.|. ..|||.|.|.| || ||.||||.....     .|.||.. ...|
atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalsee

TLAEYVVRTFALERRGYSARheVRQFHFTAWPEHGVPYHAT------GLLAFIRRVKASTP--PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD
    |...   ||..| . |  .  |....||.|||| ..        ||. .| |..|.    .|.|...||||| ||||. |.|| .. . | .. ||
keegyiltrlrleekgeerr..lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvd

IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
. . .. |   |....|. ||| |.. |..| 
vlaiieelRkdRmalvqhpeqyeflykavvey
Y_phosphatase Protein-tyrosine phosphatase 1203-1438 2.2e-57 189.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 1203-1438
Range on HMM: 1-235/235.0
NRDKNRSMDVLPPDRCLPFLISTDGDSNnYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWP--EPGRQQY
|..|||. |.|| |.    | ...|.|. ||||   ..|... .||.| .||.||  ||||.|... ...||||..|.....   | ||||  | . ..|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeeslty

GLMEVEFM-SGT-ADEDLVARVFRVQNISRLQEGHLLvRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQaESGDGRTIVHCLNGGGRSGTFCACATVLE
| ..|| . . . .... . |......  . .| . . .....  |   ...|.|.|..|.|. .| |.. |. .| ..||| .| ||.|||.|  ..||
gdikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
... .. |||. . |.||. .|.||....|| |.|.. ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1203-1438 2.2e-57 189.5 In-house 1-235 (235) alignment 
Range on Protein: 1203-1438
Range on HMM: 1-235/235.0
NRDKNRSMDVLPPDRCLPFLISTDGDSNnYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWP--EPGRQQY
|..|||. |.|| |.    | ...|.|. ||||   ..|... .||.| .||.||  ||||.|... ...||||..|.....   | ||||  | . ..|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeeslty

GLMEVEFM-SGT-ADEDLVARVFRVQNISRLQEGHLLvRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQaESGDGRTIVHCLNGGGRSGTFCACATVLE
| ..|| . . . .... . |......  . .| . . .....  |   ...|.|.|..|.|. .| |.. |. .| ..||| .| ||.|||.|  ..||
gdikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
... .. |||. . |.||. .|.||....|| |.|.. ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRA_pd Subfamily PTPRA 1162-1440 2e-56 186.3 In-house 20-296 (330) alignment 
Range on Protein: 1162-1440
Range on HMM: 20-296/330.0
KEMIRIDPQSNSSQLREEFQTLNSVTppLDvEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPD
.| |||    .. ..||||..| . .  ..   . .|    |..||| ...|| |    .|   .|    .||||.  | | .   || .  |.. |  |
eeeirirsaddnklfreefnalPagp..iq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetved

FWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQ--EGHLLVRHFQFLRWSAYrDTPDSKKAFL
|||.....  ..|||| .|.. .    | ||||. |   || . ||    |  .|.  | | ||...  .  . . ||| | |  |      |   .  |
fwrmiweqksativmltelkerkee.kcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGml

HLLAEVDKWQAESGDgRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY-L
.||..| | .  |..   .|||  | ||.|||..  .|||.... ..|||| . | ||. .|.|| |  ||.|.| | ||| |
kllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0037934 (Phosphotyrosine protein) phosphatases II 1195-1440 2.7e-56 186.2 In-house 2-242 (243) alignment 
Range on Protein: 1195-1440
Range on HMM: 2-242/243.0
CSIALLPRNRDKNRSMDVLPPDRCLPFListdgDSNNYINAALTDSYTRsaaFIVTLHPLQSTTPD----FWRLVYDYGCTSIVMLNQLNQsNSAWPCLQ
.|||||| |..||| .|.|| |.   .|     ....|||| |.. . |   .|.| .||..|. |    |||.....|.|.||||..| . .... | |
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvE.lgrekcaq

YWPepGRQQYGLMEVEFMSGTADEDLVARVFRVQNiSRLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAE-------SGDGRTIVHCLNG
|||  | ..|| ..|...| .  .| . |.....|   |.. ..||.|...| |    ..||| . .| .| || ... |       ...|...|||  |
ywp..gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

GGRSGTFCACATVLEMIrchNlVDVFFAAKTLRNYKPN-MVETMDQYHFCYDVALEYL
 ||.||..|. ..|...   . ||.. | |.||. .|. .|.| .||.|.|...||.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN23_pd Subfamily PTPN23 918-1144 7e-56 184.2 In-house 49-279 (288) alignment 
Range on Protein: 918-1144
Range on HMM: 49-279/288.0
RQEPMPaYDRHRVKLHpmlgDPNADYINANYIDGY-HRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD---TYGDIK
 .. .| ||. ||||.    . . ||||| .. .    . .|||||.|... . |||.||.... | |||...  | |. |..|||||| .   ..||..
srdilP.yDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdls

IMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA----STPPDAGPIVIHCSAGTGRTGCY-IVLDVMLDMAECE
. | ..... ..| |.. || .. .| ..|.  ..|.|||.|||     ||.|.  |..       .   |.|.||||| |||| . .|  .. .. . .
vtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgn

GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
|..|| . |..|.  | .|.|..||. |  .|.|||
glldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 908-1183 2.8e-55 182.3 In-house 40-274 (392) alignment 
Range on Protein: 908-1183
Range on HMM: 40-274/392.0
TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGrvkcsrywpedsd
..|....|  | . .  ||. ||||  .   |. ||.|| ||....  . .||.|||..  . ||||||.||. ..|.|.||| |               
aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............

tygdikimlvktetlaeyvvrtfalerRGYSARhEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC
                           .| .||  | ||||| ||...|| |.. || ||. |||     . |..|||||| ||||  | .| ..  |. 
...........................kgddar.tvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakk

EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTL
  .||..| |  .  .|  |.||.||| ||. |.||  |  .| |||  |    ...         |.   ||..|
trmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrsl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 911-1160 1.6e-54 179.7 In-house 32-281 (283) alignment 
Range on Protein: 911-1160
Range on HMM: 32-281/283.0
KDKVKgSRQEPMPAYDRHRVKLHPMLGdpnaDYINANYID---GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DS
..| |  |.. . ..|..||.|..       ||||| .|     |.... .|..|.|  . | |||.||..|. ..|||.||| |  |.|||.|||.  |
enkrk.nrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

DTYGDIKIMLVKTETLAEYVVRTFALERRGySARHE--VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDM
  ||.  . | |  |   .... . |   . ||. .  .  . .  | | |       |. | . .   |    ||||.|||.| |||. .| . . .. 
edyGeftvtlrkettsnsfiikelllrvns.sakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkd

AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT
|  | |||... || .  .|. ..|| .|| ..|...|| .|||.| |   .. .|
altesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1170-1438 2.8e-54 179.2 In-house 17-277 (288) alignment 
Range on Protein: 1170-1438
Range on HMM: 17-277/288.0
QSNSSQLREEFQTLNSVTpplDVEECSIALLPRNRDKNRSMDVLPPDrCLPFLIST--DGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD
..| ... ||...| ..      .. ... |..| .|||  ..|| |   .  .    ......||||.  |.. .. ..| |  ||..|  |||.|||.
arnrtgfseeynsLaale...ktksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YGCTSIVMLNQLNQSNSAwPCLQYWPEPGR-QQYGLMEVEFMSGTADEDLVARVFRVQnisrLQEGHLLVRHFQFLRWSAYRdTPDSKKAFLHLLAEVDK
.  . ||||..| . .    | .|||. .. ..|| ..|. ..    || | | . ..     ....| . ..|.| |.     |.||. .|.||  |. 
nktstivmltelveggkt.kCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhg.vPeskapllellrqvkv

WQAESgDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
 . .   |. |||| .| ||.||| |  ....... .. .||. . . ||. ....|.|. || |.|.| |.
anqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0051429 (Phosphotyrosine protein) phosphatases II 940-1162 5.8e-54 178.8 In-house 3-241 (272) alignment 
Range on Protein: 940-1162
Range on HMM: 3-241/272.0
NADYINANYIDGYHR---SNHFIATQGPKPEMVYDFWRMvWQEHCSSIVMITKLVEVGRVKCSRYWP-------------EDSDTYGDIKIMLVKTETLA
  .||||....||.|    . .....|| |  . ||||. .......||......|.||.||.||||             . . .||.. ..|...|.| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EYVVRTFALERR-GYSARHEVRQFHFTAWPEHGVPYHAtgLLAFIRRVKAstppdAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD--------IY
 |..|.. |..  .... .||...|.|.|| ||||..|  ||.... . .      ||...||||| .|||....|. .|   . | .||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NCVKTLCSRRVNMIQTEEQYIFIHDAILEAcLCGETTIPVSEFKATYK
..|. | ..| ...||||||.|...|.||. |.. ...... ..|...
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaald
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 894-1148 8e-54 177.4 In-house 17-296 (301) alignment 
Range on Protein: 894-1148
Range on HMM: 17-296/301.0
FKQEYESFFEGWDA----TKKKDKVKGSRQEPMPAYDRHRVKLHPM--LGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMI
|...|..  || |     . .... . .| . .  || .|. |.|.  |   . .||||.||||| ....|||.|||  . . ||||..|||. .||||.
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TKLVEVGRVKCSRYWPE---DSDTYGDIKIMLVKTETLAEYVVRTFALERRG-----Y----------SARHEVRQFHFTAWPEHGV-PYHATGLLAFIR
|.| |  . || .|||.   .|...| ....||.. .. ..|.| ...  .      |           . ..| |.. | ||..|| . ..| | .   
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

RVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCG
 ...   .. ||.|.|||.. .|.| |. ... |. .  |||||... .|..   .  ...| |||..|.|.| .   . 
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_PTPRN_pd Subfamily PTPRN 896-1143 9.6e-54 177.1 In-house 39-290 (297) alignment 
Range on Protein: 896-1143
Range on HMM: 39-290/297.0
QEYESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYI-DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVG
 .||.  .  ...|... ||  |.. . .||  ||||.    . . |||||  | |   |.  .|||||| .. | |||.|||.. .  ||..|.| | |
cayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg

RVKCSRYWPED-SDTYGDIKIMLVKTETLA-EYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRT
  .|.||||.. |..|.  .. ||     . .|.||.| |     |    | |||| .|||.|||  |  || | |.|  |    . |||.|||.|.|||
vkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrt

GCYIVLDVMLD-MAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
|.||..|..|. ..     .||   .. |  .| ....|..|. |.  |. |
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN1_pd Subfamily PTPN1 916-1149 1.6e-53 176.3 In-house 35-277 (290) alignment 
Range on Protein: 916-1149
Range on HMM: 35-277/290.0
GSRQEPMPAYDRHRVKLHpmlgDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD----TYG-
  |   .  ||  |.||.    . . |||||. ..  .   ..| |||| |. |  ||.|||.... ..||. |.|| ...|| .|||.. .    ..  
lnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellled

-DIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAS--TPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC
  .|. |...|.  .|.||.. || .     .|. .||.|.||. |||   . .| |. .|. |    .| || ||||||| ||.| ....| .|   | 
tklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliek

EGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC--GE
..    ||| . .  | . |. .||| .|  | . ||||   .  |.
kddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1161-1443 4.5e-52 171.8 In-house 7-281 (287) alignment 
Range on Protein: 1161-1443
Range on HMM: 7-281/287.0
YKEMIRIDPQSNSSQLREEFQTLNSVTPplDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLIstdGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
. |... ... .. . .. |..|..||   . .|  ... ..|.||||. ..|.||     |    |  ..||||.  |.|  . |||..  |. .|  .
fgefvakghakgnegfknqftvleqvtq..redevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarn

FWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEgHLLVRHFQFLRWSAYRDTPDSkKAFLHL
||.|. |   | |||| |.....    | |||||     .|  ..|... .  .. . | ..|.| .. .. .. |. .|.  |   .. ..  .. | .
fWkliddrnvtaivmlcqekende.evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtep.qtillv

LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGL
. |  | |  .|..  .||| .. |||..||| || ..  .    .|||   |  |  ||..| |..||.| .|. ||||.  
ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_PTPRG_pd Subfamily PTPRG 1153-1442 1.4e-51 170.4 In-house 2-289 (563) alignment 
Range on Protein: 1153-1442
Range on HMM: 2-289/563.0
PVSEFKatyKEMIRIDPqSNSSQLREEFQTLNSVTPPLDVeECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNN--YINAALTDSYTRSAAFIVT
||.||.   | .. .   ..   . |||. |.| | . |. ... .  | |. ||| ..... ||    | .. |  ..  ||||   | | .| |||.|
pvkefa...khvaslha.dgdigfseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiat

LHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN--ISRLQE--GHLLVRHFQFLRWSA
 .||..|. ||||....   . |||. .|.... .  | .|||. . ..|| ..|  ..         | . ..|  . . ..   ..|||.... .|  
qgplkdtfddFWrmiWeqnvaiivmitnlverg.rrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

yRDTPDSKKAFLHLLAEVdkwQAESG--DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
  ..|...   |         .|      | ..||| .|.||.||...  |.|. |. .| |.||  .|..|  ....|.| .|| | .|. || . .
.hgvPehslpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1152-1444 2e-50 166.3 In-house 2-287 (290) alignment 
Range on Protein: 1152-1444
Range on HMM: 2-287/290.0
IPVSEFKatykEMIRIDPQSNSSQLREEFQTLNSVTPPLDVeecSIALLPRNRDKNRSMDVLPPDRCLPFL--ISTDGD-SNNYINAALTDSYTRSAAFI
|||..|     |..  . . . .. |..|..|.|   .  |    ..| . |. .||. .....|     |  || . | .|.||||.  . |  . ..|
ipvdkfg....efvanghakgnegfrnqfkmldsgesehtv...tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyi

VTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLqEGHLLVRHFQFLRWSAYR
.|  |...|  |||.|...  .| |||| . .....   | ||||. . ..|| .... .. .. .. . | ..|.| .   . .  | ..|.  |    
atqgpvsntlvdFWkliwqekvtiivmltniieegk.vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstg

DTPdSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE
. .  ... |....|. | |  .|..  .||| .. |||..||| || ..  .    .|||   |..|  ||..|.|..||.. ... |.||. .|
kvt.npqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1164-1441 2.2e-49 163.2 In-house 12-284 (305) alignment 
Range on Protein: 1164-1441
Range on HMM: 12-284/305.0
MIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAllpRNRDKNRSMDVLPPDRCLPFLISTDGdSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWR
 |. .   ....| .....| .   ..||.. .     ......... .|..||.     ....  ..||||.  |.| |. ..||.  ||..|  ||||
yikearvysdkgleaqykslyeeeesidvgkkean...kaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlkntvadfWr

LVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQ--QYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHlLVRHFQFLRWSAyRDTPDSKKAFLHLL
|....  ..|||| .| . .    | |||||  ..  ..| ..||  | .. .|.. | ... . .  .|..  | ..|.  |      |..  ..|.|.
liveekvstivmltklveggkd.kCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesr.tvlqyqltdWPd.hGvpqfatsllsli

AEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 .| | | .. .   .||| .| ||.|.|.|    || ..  . ||||   |.||. ...||.|.||| |..|.  |...
krvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1176-1440 4.1e-49 162.5 In-house 21-288 (325) alignment 
Range on Protein: 1176-1440
Range on HMM: 21-288/325.0
LREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLIST-DGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIV
 .. |     ..|. |     .| .| |..|||  .|.. |.  . | .  |  | .||||.   .. .   |. .  || .|. |.||||.|. |. .|
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv

MLNQLNQSNSAwpCLQYWPEP--GRQQYGLMEVEFMSGTADEDLVARVFRVQNISrlqEG-HLLVRHFQFLRWS--AYRDTPDSKKAFLHLLAEVDKW-Q
.||.|.. .    | .|||.     ...| .||....     | | ||. |....   .|  . |. ||.  |     .  | .  ..|.|. .|..  .
vlneldlgkdr..cavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk...kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

A-ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
|   . .  .||| .| ||.|.| .  ..|. .  .  ||.|   | ||. .|.||||.||| ..|.   |..
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 911-1142 4.9e-49 161.6 In-house 36-274 (287) alignment 
Range on Protein: 911-1142
Range on HMM: 36-274/287.0
KDKVKGSRQEPMPAYDRHRVKLHpMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD--T
  .||  |   .  .|  || |    |.  .|||||||. .|.. . |||.||| .  | ||||.|.... .|....|. || .| || .||||      
laavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

YGDIKIMLVK-TETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRV-----KASTPPDAGPIVIHCSAGTGRTGCYIVLDVML
 |   ..|.. .    || ||.. |        . |.|... .||.....  | ||. |.  |      |    ..||.|.|...| ||.| .. . |..
vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
.. |  | ||. . |  |  .|  ..|.  |. .. .|. 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRB_pd Subfamily PTPRB 1152-1441 2.9e-48 159.4 In-house 7-286 (293) alignment 
Range on Protein: 1152-1441
Range on HMM: 7-286/293.0
IPVSEFKATYKEMIRidpqSNSSQLREEFQTLNSVTpplDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVT
| ...|.. .|.| .     .  .. ||...|..|      .....| |..||.|||  ..|| |     | .... ....||||   . |.    ||.|
iklekfeehvkkmka....dsdlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

LHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCLQYWPEP-GRQQYGLMEVEFMSGTADEDLVARVFRVQNisrlQEGHLLVRHFQFLRWSAYrD
  || .|. ||||.|..  .. |||| ||        | .|||.    ..|| ..|.... .  || | | .....    .. .  ||...|. |. . .
qGPlpetvddfWrmvwekkssiivmltqlvekg.kvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdh.g

TPDSKKAFLHLLAEVDKWQ-AESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 |.. |..|... .|....  .. .. ..|||  | ||.||| |  ..|. |. ...||.|     ||. . ..| | .|| | ... |..|.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0036282 (Phosphotyrosine protein) phosphatases II 942-1139 9.7e-48 157.5 In-house 3-164 (174) alignment 
Range on Protein: 942-1139
Range on HMM: 3-164/174.0
DYINANYIDGYHRSNHFIATQGPKPemvydFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEdsdtygdikimlvktetlaeyvvrtfalerRGYSARH
|||||...|........||.||| .     ||.|.........|| ....| |..|| .||||                              . .. ..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredler

EVRQFHFTAWPEHGVPYHATgLLAFIRRVKASTPP-DAGPIVIHCSAGTGRTGCYIVLDVMLDMAEcEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD
.. |.... || ||||  .. || |...|.      . ||...||||| ||||. .... || . . |..||... |..| . | .|.||..||.|...
lgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 919-1153 2.7e-47 156.0 In-house 7-179 (182) alignment 
Range on Protein: 919-1153
Range on HMM: 7-179/182.0
QEPMPAYDRHRvklhpmlgdpNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITklvevgrvkCSRYWPEDSdtygdikimlvk
 .  . ||. |          . ||||||...|......||||||| .. |.||.||........||..|         . .||||.             
ysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell............

tetlaeyvvrtfalerrgysaRHEVRQFHFTAWPEHGVPYhATGLLAFIRRVKAstppDAGPIVIHCSAGTGRTGCYIVLDVMLDMaeceGvVDIYNCVK
                      ... |.... || ||||     ||.||..|..    . ||...||||| ||||.......|. .    | |.....||
.....................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavk

TLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIP
.. ||| .|..|..||.|...|.|| .|...|...
lvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1146-1439 4.6e-47 155.9 In-house 5-291 (319) alignment 
Range on Protein: 1146-1439
Range on HMM: 5-291/319.0
LCGETTIPVSEFKATYKEM-IRIDPQSNSSQLREEFQTLNSVTPPLdvEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTR
| ||. . | .|.| |... .. | . . ..|. ||. .  ....|   . . | |..|.|||| ...|. |.    |  ..|    .||||.  . | |
lfgesdvavpdfpayyqqlsnksdfdddltklevefrracklgvnl..adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr

SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNqlnqsnsAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQeGHLLVRHFQFLR
   .| .  ||. |  ||||....| |..||.|           | ||||  . .... ..|.  | .  .. | | ... . .. . .   .. | || 
kdkyiaaqGPldntladfWrmiweyncstivllt.......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflG

WSAYrDTPDSKKAFLHLLAEVDKW-QAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE-Y
|  .   ||.   .. |.  | .  . | .    .|||  | ||.|.. .  ..|....  . |||.   . ||. ....|. . ||.|.|   || .
wpdv.GvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPN14_pd Subfamily PTPN14 907-1142 9.5e-47 154.4 In-house 43-293 (300) alignment 
Range on Protein: 907-1142
Range on HMM: 43-293/300.0
ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDpNADYINANYIDGYH--RSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE
..| .. .. .| . .  |.  ||.| |   . . .||||  |      .. ..|..||| .  | |||.|||... . |||.|.  | |. |. .|.|.
taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

D-----SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKA-----S-TP---PDAGPIVIHCSAGTG
.     . ..|  |..   .|.   .. ... |.    . . .|  . .| ||.||||   .| | ....|..     . .        |...||||| |
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
|||  |. |...   |.. ..|| . ...|  .|  ..||  || |......
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1200-1439 9.9e-46 151.1 In-house 46-278 (315) alignment 
Range on Protein: 1200-1439
Range on HMM: 46-278/315.0
LPRNRDKNRSMDVLPPDRCLPFL-ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPgRQ
   |..||| ..... |.  ..| .    .  .|.||.. | |..   .| .  |. ..  ||||||... .. ||||..| . .    . .|||.  . 
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekr.kaekywpdk.kv

QYGLMEVEFMSGTADEDLVARVFRVQNISRLQEghllVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAESGdGRTIVHCLNGGGRSGTFCACATVLE
 || . |  .|    ...  | . |   ....|    |  ...  |    . | .  ....|   | ... .|  |  .||| .| ||.|||..  .||.
iyGkitvtrkseevnteytvrtlsvvfgdnire....vvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavld

MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
 .   |..||. . . .|. . .||....||.| ||. || 
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1203-1441 4.5e-45 149.1 In-house 51-285 (297) alignment 
Range on Protein: 1203-1441
Range on HMM: 51-285/297.0
NRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRsaAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSawPCLQYWPEPGRQQYG
| .|.|  ..|| |.    | ... | . .|.||.   ..     .| |  | ..|  |||..|.|.  . |||||..|...    | .||.. | ...|
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk..kcaryWsdkgvttfG

LMEVEFMSGTADEDLVARVFRVQNISRlqEGHLLVRHFQFLRWSAYRDTP-DSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMI
 . |. .| .  |  . | . |.. .     . .|. .||..|        || ...|.|. || |   .  .|  .||||.| || | ...   |.  .
dvsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea

RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
. .. ||.|   | ||. .|..| | .||.| | . ||.| 
krekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1181-1438 5e-45 148.6 In-house 13-264 (283) alignment 
Range on Protein: 1181-1438
Range on HMM: 13-264/283.0
QTLNSVT-PPLDveeCSIALLPRNRDKNRSMDVLPPDRclpFLISTDGDSNNYINAALTD---SYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVML
..|. .. |.||   . ||   .|. |||  ...| |.   . .  . .|..||||.      || ..  .|..  ||. |  |||..|.|   |.||||
evlkrlsvpdld...adiasadenkrknrnqeivpadq...wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

NQLNQSnSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEgHLLVRHFQFLRWSAYRDTPDSKkaFLHLLAEVDKWQAESGDGRT
 .| .      | ||||. | ..|| . |     |. . .. . . ... |  ..  ||. |.|.  |  | . .      |  .  |   | || .|  
tklqed.lrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssaks.tlllahyqvidWleygeqaiin..slvkfnkvislqteskkgPi

IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
.||| .|.||...|.| .. .. .. . .||||   | .|. .. .| |.||| . ....||
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN9_pd Subfamily PTPN9 1176-1440 7.9e-45 148.1 In-house 18-290 (297) alignment 
Range on Protein: 1176-1440
Range on HMM: 18-290/297.0
LREEFQTLNSVTPpldVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIV
|..|.. . . ..   . .   . |. |  |||  |||  |.   .| ..|.|.  .||||  .| | .  ||| |  ||. |. ||||.|..  .  ||
lskeyaeirnepv...eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLNQLNQSNsAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHllVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAE--
|  .. .      | ||||  |  ....| ..|. ..    || . ||. ..|.   .. .  | ||||| |  |  .|.| ...|..| .| . ||   
mttrvverg.rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrk..vthfqflsWPdy.GvPssaaslldvlekvrekqalav

----------SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
            .   .|||  | ||.|||..    |. ..  . |||. . |.||. .  .. | .||.|||   ||| 
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Ptp69D_pd Subfamily Ptp69D 1175-1440 1.5e-44 147.4 In-house 23-286 (307) alignment 
Range on Protein: 1175-1440
Range on HMM: 23-286/307.0
QLREEFQTLNSVTPPLdveECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
 | .|...|.. . ..   .....    |  |||. |. . |.    |  . |.   .||||    .|  .  ||.   |...|  ||||.. .   | |
glakeyekLeareidk...stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLNQLNQSNSAwPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQ---EGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAE
||| .|.. | .  | .|||.   .||| . |...|    .| . | . | ..       | .  |  .... |      |.. .. |.|. .| . .  
vmlsnlteknrk.kcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

SgDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.  .  .||| .| ||||.| | . .|. ..  . ||.|   | ||. .. .|. ..|| |.|   |.| 
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1192-1441 2e-44 146.7 In-house 33-278 (315) alignment 
Range on Protein: 1192-1441
Range on HMM: 33-278/315.0
VEECSIALLPRNRDKNRSMDVLPPDRCLPFL-ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCLQ
. .  .|  . |  |||  ..|| |.    | .  |   ..||||.   |.    |.| .  ||...  ||||.|...  |.|||........    | |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegd.kikcrq

YWPE--PGRQQYGLMEVEFMSGTADEDLVARVFrvqnISRLQEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWqAESGDGRTIVHCLNGGGRSG
|||.      ..| ..|| .|  || | ||| .    . |  | .  |  |||  |   . ..    ..|.|. ||     .. .   .|||. | ||.|
ywPdrkadsvefGsikvellsleadtdgvarkl....vtrkseesrtvtqfqftewPd.kGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

TFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 ...   |.. |.  . ||||   |.||. .| .| | ..| | ||. ||.| 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1193-1439 6e-43 142.4 In-house 15-255 (284) alignment 
Range on Protein: 1193-1439
Range on HMM: 15-255/284.0
EECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNqlnqsnsAWPCLQY
 . . | |..|.|||| ...|. |.    |  ..|    .||||.    | |   .| |  ||. |  ||||....| |..||.|           | ||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.......kdkcsqy

WPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQeGHLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKW-QAESGDGRTIVHCLNGGGRSGTF
||  . .... ..|.  | .  |. | | ... . .. . .   .| | || |  .   ||.   .. |.  | .  . | .    .|||  | ||.|..
wplkivikeerfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdv.gvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

CACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE-Y
 .  ..|....  . |||.   . ||. ....|. . ||.|.|   || .
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1203-1441 1.1e-42 140.8 In-house 43-277 (515) alignment 
Range on Protein: 1203-1441
Range on HMM: 43-277/515.0
NRDKNRSMDVLPPDRCLPFL-ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPE-PGR-QQ
|  |||  ..|| |.    | .  |   ..|.||.   |.    |.| .  |..... ||||||...  | |.|...|....    | .|||. ||   .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdki.kcgkyWPdkpgdsvk

YGLMEVEFMSGTADEDLVARVFRVQNISRlqegHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQAESGdGRTIVHCLNGGGRSGTFCACATVLEM
.| ..|| .|  |. . . | ..|   .        |  |.|  |   . .|   ...| |. ||   . .      |.||. | || | ...   |.  
fGsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPd.kGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvah

IRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
..  . ||||   . .|. .| .| | .|| | |.. ||.| 
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0046846 (Phosphotyrosine protein) phosphatases II 933-1142 4.5e-42 139.1 In-house 4-170 (176) alignment 
Range on Protein: 933-1142
Range on HMM: 4-170/176.0
HPMLGDPNADYINANYIDGYhrsnHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGdikimlvktetlaeyvvrtfal
...  |.. ||||||.|.|.    ..|||||| |. ..||..|....... .|..|..|| ||.|| .||||  .                         
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

errgysarhevrQFHFTAWPEHGVPYHaTGLLAFIRRVKASTPPDaGPIVIHCSAGTGRTGCYIVLDvmldMAECEGVVDIYNCVKTLCSRRV-NMIQTE
            |.... ||.|||| . . || ... ..     . ||...||||| ||||......    . |.|  .......... ..|  ...||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYIFIHDAIL
||| |.....|
eQyrflyefel
subfamily_PTPN23_pd Subfamily PTPN23 1171-1441 8.9e-42 137.9 In-house 12-281 (288) alignment 
Range on Protein: 1171-1441
Range on HMM: 12-281/288.0
SNSSQLREEFQTLNSVTPpLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLIstdGDSNNYINAALTDSYT-RSAAFIVTLHPLQSTTPDFWRLVYDYG
.. ..| ..|. |..     . .. |||.  .. .|||| |.|| |.    |    |  ..||||.   . .  .  ||.|  |||||  |||..||.  
dgktaldkkfkeleqkqd.kearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

CTSIVMLNQLNQSNSAwPCLQYWPEPG--RQQYGLMEVEFMSGTADEDLVARVFRVQNISrlQEGHLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDK-
   |||| . .. .    . .||||     ...| ..|   | .  |  | ||....  .  ..    |.| |.  |. .   |.| . .|..| ||.. 
ssviVmllskeelgkp.kvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld..adavksvshlqltsWpel.GvPasPetllqfldevesa

WQAESGDGRT--IVHCLNGGGRSGTFCACATVLEMI-RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
..|.    .|  .|||. | ||.|.|.   .... . . . |.|.    ..||. . .||.. .|..|.|.. ||. .
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_PTPN6_pd Subfamily PTPN6 1158-1441 1.8e-41 137.1 In-house 10-298 (306) alignment 
Range on Protein: 1158-1441
Range on HMM: 10-298/306.0
KATYKEMIRIDPQSNSSQLREEFQTLNSVTpPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTD--SYTRSAAFIVTLHPLQ
.   .|. . . . . . . |||..|.      .. . . .  |.|. |||   .|| |     | . .   ..||||   .  . . ....| |   |.
eqrvselekeeeslekagfeeefeelqqee.akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

STTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGR-QQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHlLVRHFQFLRWSAyRDTPDSK
.| .||||.|..  .. |||. . .  .    | .|||.  . ..|| ..|. .| .. .| . | ..|..... .| .  |....|  |    ..| ..
ttvsdFWrmvwqensrvivmttkevErgke.kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeer.evfqyhfksWPd.hgvpkdp

KAFLHLLAEVDKWQAESG---DGRTIVHCLNGGGRSGTFCACATVLEMIRCHN---LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
.|.|..| .|.. | |.     | ..||| .| || |||    ..|..|. .     .|.  . |..|...  .| | .||.| | .  .|.|
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0043147 (Phosphotyrosine protein) phosphatases II 938-1138 3.6e-41 136.1 In-house 2-154 (172) alignment 
Range on Protein: 938-1138
Range on HMM: 2-154/172.0
DPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLvevgrvkcsrywpedsdtygdikimlvktetlaeyvvrtfalERRGY
|.. |||||.|.|.|.  ..||||||| .. . |||||....... ||..|.|                                          .  ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

SARHEVRQFHFTAWPEHGVPyHATGLLAFIRRVKA-STPPDAGPIVIHCSAGTGRTGCYIVLDVMLdmaecEGVvDIYNCVKTLCSRRVNMIQTEEQYIF
   ... |.... || |||| ..  || |.. ..      . ||...||||| ||||. .... ||     .|. .....|... ..| ...|...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrf

IH
..
ly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 913-1143 4e-41 135.6 In-house 56-281 (290) alignment 
Range on Protein: 913-1143
Range on HMM: 56-281/290.0
KVKGSRQEPMPAYDRHRVKLHPmlGDpNADYINANYIDGYHrsNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS---DTY
..|  |   ..  |. || |.   |  . ||. |||..| .    || |||.  . | |.|||| ||. . |||. .|.| |. ||..|.|| .    |.
efkknrykdvvcndktrvilkd..Gy.dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GDIKIMLVKTET-LAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAStppdAGPIVIHCSAGTGRTGCYIVLDVMLDMAECE
|.| ..  . ..  |. . .|...  .     | .. ..  .||.. |.  .  ||  .| ..      .||.|.||||| |||| .. ..| |..    
GeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldG

GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
  .|. . |..|   |.| .| . ||. . ...|.
keldlldlvralrnsrlnsvqvdiqylalveilld
0041856 (Phosphotyrosine protein) phosphatases II 1203-1441 1.7e-40 133.9 In-house 1-172 (182) alignment 
Range on Protein: 1203-1441
Range on HMM: 1-172/182.0
NRDKNRSMDVLPPDRCLpflistdgdSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNqlnqsnsawpCLQYWPepgrqqygl
|.|||| .|.||.|. .          ..|||| | ... ..  ||.| .||.||..||.|.....|.|.||.|.          . .|||         
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp.........

mevefmsgtadedlvarvfrvqnisrlQEGHLLVRHFQFLRWSAYRDTPdsKKAFLHLLAEVDKwqaesGDGRTIVHCLNGGGRSGTFCACAtvleMIRC
                           .. . |. ....| |  .  ..     .|... || .      .|...|||  | ||.||..|.     ....
...........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay....lmkk

HNlVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
.. |... | |..|...|.||.|..|| |.....||.|.
lg.vsleeavklvrsrRpgmvitpnqyfflqlallelll
MAM MAM domain 27-187 2.3e-40 126.3 Pfam-A 1-159 (160) alignment 
Range on Protein: 27-187
Range on HMM: 1-159/160.0
CTFEEAsdpavPCEYSQAQYDDFQWEQVRIHPG---TRAPADL--PH--GSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGhspGTLGV
|.|||       |..|| . ||..|..|. . .   |  . |    .  |.|..|.||..|.|..|... ..|......|..|.|......    ||| |
CdFeee.....lCgwsqdetddldWtrvsgstptektgpssdhtlgkesghymyvetssgaegesarllspllpasssaClrFyyhmsgsev...gtLnv

YVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFwPNEYQVLFEALISPDRRGYMGLDDILLLSYPCA
||| ....  ...|...|..|..|..||...|.. ....||.||| .. ...|.. |||| | ...|.
yvreekegeetllweisgnqgssWqeaevtlsai.tkkfqvvfeavrgkgsegdialDdislsegeCs
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 917-1146 8e-40 131.7 In-house 45-278 (307) alignment 
Range on Protein: 917-1146
Range on HMM: 45-278/307.0
SRQEPMPAYDRHRVKLHpmLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED---SDTYGD--
 | . ... |. |. ..  .    .||| |||.    . ..||..|||. . .|.|| |. ||.  |..|. |..|....|| .||| .     ..|.  
nryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap

--IKIMLV--KTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAstppDAGPIVIHCSAGTGRTGCYIVLDVMLD-MAE
  | .  .  |. .  | ..   .|.    .    .... .. ||..|||    . . ..  |.     |  |.|.||||| ||.|  . . .. | | .
ntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtivaislvqdkmia

CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL
 .   |. . |. | |.|   |||| ||...|  .||  |
Ginckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_PTPN3_pd Subfamily PTPN3 1165-1437 8.9e-40 131.4 In-house 6-272 (280) alignment 
Range on Protein: 1165-1437
Range on HMM: 6-272/280.0
IRIDPQSNSSQLREEFQTLNSVTPPLDVeecSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGdsnNYINAALTD----SYTRSAAFIVTLHPLQSTTPD
...  . .| ..  .|..|    | |..   |.| .|.| .|||  |.|| |     | ...    .||||   .    | . .  .|.|  ||..|. |
lllkeglesGavlaqfeqlyrkkpglai...saarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatd

FWRLVYDYGCTSIVMLNQLNQSNsAWPCLQYWPEPG-RQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHllVRHFQFLRWSAyRDTPDSKKAFLH
||..|..  .. |||| .| ..     | |||||.. ...|| ..|.  .  ...  | | . ... .  .| .  . ..|.| |.   . ||... ||.
fWqmvweqksslivmlttlverG.rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerk..ilqlqylaWpd.hgvPddsadfle

LLAEVDKWQAESgDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL
.. .| | .. . .  ..|||  | ||.| . .  | | .| ... | .    .|.|. . ..|.|..||.|  .  |
fvervrklrsgk.eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1174-1441 9.2e-40 131.4 In-house 5-269 (274) alignment 
Range on Protein: 1174-1441
Range on HMM: 5-269/274.0
SQLREEFQTLnsvtpPLDVeECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSN--NYINAALTDSYT-RSAAFIVTLHPLQSTTPDFWRLVYDYGC
 .|..||  |     ||.. .     ....  |||  ..|| ..    | | .....  .||||     |  .| |.. |  ||..|  ||||..|   .
kdlekeflel.....Plnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeev

TSIVMLNQLNQSNSAwPCLQYWPEPGRQ----QYGLMEVEFMSGTADEDLVARVFRVQNISRLQEghllVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDK
. |||| .|...| .  | .|.|.        .|| .|... . .  .|   | . ... .| ..    | |. .  |   ...||. ...|.|..||..
qvivmltklkeaneq.kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPd.hksPddantlldlvlevee

WQAESGD--GRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 . |.    . ..|||  | || | | |    .  .| .. |||.     ||  .  ||.| .||.. . .  .||.
sreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1170-1441 6.2e-39 128.8 In-house 11-277 (281) alignment 
Range on Protein: 1170-1441
Range on HMM: 11-277/281.0
QSNSSQLREEFQTLNSVtpplDVEECSIALL-PRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD
|.... . ||...|...    .|.. . |   . |. ||| ...   |     .  .. . ...||||   ..|.  ...|.|  |. ..  .||..|..
qndnaGfieeyeklaai....gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

YGCTSIVMLNQLNQSNSaWPCLQYWPEPG-RQQYGLMEVEFMSGTADEDLVARVFRVqNISRlqEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDK
.  . |||. .  ...    | .|||..  . .|| . |.... .. .  . |.|.. . .     .  |...... |      |.. |..|.  .|| |
qkvsaivmvtreieagk.lkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eres..getreveqlaytaWPd.hGvPattkellefrkevlk

WQAESGDGRTIVHCLNGGGRSGTFCACATVLEMI-RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 . .. .   ..||  | ||.||. |  .... . . .. .||    . ||. .  || |. ||.| | . |..|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0049260 (Phosphotyrosine protein) phosphatases II 948-1139 9.4e-39 127.9 In-house 1-144 (152) alignment 
Range on Protein: 948-1139
Range on HMM: 1-144/152.0
YIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWpedsdtygdikimlvktetlaeyvvrtfalerrgysarhevrQFH
.||||.....||||||| |. . |||||... ... |||.|.|.| |..|| .|.                                          |..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLdmaeceGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD
.. || |||| ..  || ... ..     . ||...||||| ||||...... ||        |.....|. . ..| .......|..|...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPRN_pd Subfamily PTPRN 1171-1437 1.2e-38 127.5 In-house 26-289 (297) alignment 
Range on Protein: 1171-1437
Range on HMM: 26-289/297.0
SNSSQLREEFQTLNSVTPplDVEECSIALLPRNRDKNRSMDVLPPDRCLPFL-ISTDGDSNNYINAA-LTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDY
.| ..|..|...| .     . . ...|  ..| .|||| .||| |     |  ... ....||||. ..|.  |..|.| |  || ||  |||..|.. 
knkdrlekewealcayea..epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

GCTSIVMLNQLNQSnSAWPCLQYWPEPGRQQYGLMEVEFMSGT-ADEDLVARVFRVQNISRlQEGHlLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKW
|.. ||.| .|... .   | .|||. | . |.. ||...|     .| . | | ..|.   .|    |  | || | . ...| | |..|..   |.| 
Gvvvivnltrleee.gvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt.setr.tvtqfhflswpe.egvPasaksllefrrkvnks

QAEsGDGRTIVHCLNGGGRSGTFCACATVLE-MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL
         .||| .| ||.|....   ||. ...  . .|.  . . ||. .|..|.| ||..|.. .  
yrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0036282 (Phosphotyrosine protein) phosphatases II 1230-1435 3.9e-38 126.2 In-house 2-165 (174) alignment 
Range on Protein: 1230-1435
Range on HMM: 2-165/174.0
NNYINAALTDSYTRSAAFIVTLHPLQsttpdFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPEpgrqqyglmevefmsgtadedlvarvfrvqnisRL
..||||   | . ..  .|.. .||.     ||......|.|..|||..... .  . | .||||                                 . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleeke.lglykcinywpe.................................lr

QEGHLLVRHFQFLRWSAYRDTPDSKkaFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRcHNLVDVFFAAKTLRNYKPNMVETMDQY
.  . |. ....| |  .   ..|.  .|... .|.....|...| ..|||  | ||.||..|.  .| ... ..|||..   ..||...|.||.|..||
edlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

HFCYDV
.|.|..
rflyyf
subfamily_PTPN12_pd Subfamily PTPN12 1171-1440 7.7e-38 125.0 In-house 5-277 (290) alignment 
Range on Protein: 1171-1440
Range on HMM: 5-277/290.0
SNSSQLREEFQTLNSVTPPLDVEE---CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVY
... .. .|||.| ...  .  |.    . .  ..|. |||  |.|| |     |  ....  ..|||| .    . . ..| .  ||  |  ||||...
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYGCTSIVMLNQLNQSNsAWPCLQYWPEPGRQQ--YGLMEVEFMSGTA-DEDLVARVFRVQNIsrlqEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAE
..  . .||. ..   .    | .|||| | ..  .| .||. ..  | |.|.. | ..|..     . .  |. |..  |   ...| |.|  |.|...
eknveivvmaCrevelg.kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPD.hgvPssakslleliel

VDKWQAeSGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNL---VDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
| . |  | |   .|||  | || || .|   | |... ...   .|||    .||. .. .| | .||.. |   .|..
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN13_pd Subfamily PTPN13 1172-1442 9.4e-38 125.0 In-house 9-271 (273) alignment 
Range on Protein: 1172-1442
Range on HMM: 9-271/273.0
NSSQLREEFQTLNSVTPpldVEECSIALLPRNRDKNRSMDVLPPDRCLPFListdGDSNNYINAALTDSYTRS--AAFIVTLHPLQSTTPDFWRLVYDYG
.. |  |||..|. . |   ...|...   .|.||||  .||| |.    |    ||. .||||.|           .|..  ||  |. |||..|..  
dqqqPaeefkelrelkp...ldtcevgkkkenkdknryrnvlPydetrvkl....gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

CTSIVMLNQlNQSNSAWPCLQYWPEPGRQQYGL---MEVEFMSGTADEDLVARVFRVQNISRLQEGHllVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDK
.. |.|. . .. .    | .||||  ...  .   .||| .  .  ...| | . |...   .  .  | |..|  |  . ..| | . .|...||| .
aeviamvtl.ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesre..vahlnfvkwPdh.gvPssaaellqfvaevrr

WQAesGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
 |     |  .|||  | |||||. .  .||..|   . .||    ..||. .  .| | ||| |.| ..|| |. 
lqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 902-1145 2.5e-37 123.2 In-house 37-287 (305) alignment 
Range on Protein: 902-1145
Range on HMM: 37-287/305.0
FEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLgdpNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRY
||   | |. .. .  |   .   |. ||||..       .|| |||.     .. || || |  .   ||| | .|..  .| |. .|.| |  ||. |
fekmkafkeaqeagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcley

WPEDSDTY-----GDIKImLVKTETLAEY----------VVRTFALERRGYSARhEVRQFHFTAWPEHGVPYHATGLLAFIRRVKastpPDAGPIVIHCS
.. . .       .. ||  || |. ...              . .|  | .||  | ..|.  ||. |||   . .| .. . .    |  ||||.|||
faskdkdvlefeekgqki.svkfessvtlkfrkdakakvtetvlviegpgekar.kvthyhwidwpdrgvpaadlailellekar....pskgpivvhcs

AGTGRTGCYIVLDVMLDMA-ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
|| ||||  ..|. .||   . . . |    .. .. .| | |||..||.|.|. ||. .
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0049772 (Phosphotyrosine protein) phosphatases II 1195-1443 4.3e-37 123.9 In-house 38-283 (314) alignment 
Range on Protein: 1195-1443
Range on HMM: 38-283/314.0
CSIALLPRNRDKNRSMDVLPPDrCLPFLISTDGDSNNYINAALTDSYtrsAAFIVTLHPLQSTTPDF----------WRLV--YDYGCTSIVM-------
. .| |..||||||..|.|| | .. .| . .... .||||   |..    .||.| .||. |  ||          ||.|  .|. .  |||       
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LNQLNQSNsawpclqywpepgrQQYGLM-----EvefmsgtadedlvarvfrvqniSRLQEGHLLVRH-FQFLRWSAYRDTPDSKK
              |..|   .               ..  .     .                      ..| ...|. |. ...||.  . ..... .
delsrLdaAlgKtpllildgng..............neptaadlellk......................eelydpelferlgikylripvpDgsaplle

AFLHLLAEVDKWqaeSGDGRTIVHCLNGGGRSGTFCACATvleMIRCHNLvDVFFAAKTLRNYKP-----NMVETMDQYHFCYDVALEYLEGL
 |...|. ....   . .|...|||  | ||.|||...|    ....... ..  | . .|.  |     ...|. .|| |.... ||||. |
dfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0049772 (Phosphotyrosine protein) phosphatases II 922-1145 6.7e-37 123.3 In-house 55-280 (314) alignment 
Range on Protein: 922-1145
Range on HMM: 55-280/314.0
MPAYDrHRVKLhPMLGDPNADYINANYIDGYhrsNHFIATQGPKPEMVYDF----------WRMV--WQEHCSSIVM---------------------IT
 . .| .||.| | |.  . |||||.|.||.   . |||||||... |.||          ||||  .. ..  |||                     ..
ilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpll

KLVEVGrvkcSRYWPEDSDTYGdikimlvktetlaeyvvrtfalERR--GYSARHEVRQFHFTAWPEHGVPyHATGLLAFIRRVKAStpPDAGPIVIHCS
.| . |    . ....| ...                       |.   .    ... ... . .| ...|     ...|.. ...   .. ||...||.
ildgng....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCk

AGTGRTGCYIVLDVMLDMAeceGVvDIYNCVKTLCSRRV-----NMIQTEEQYIFIHDAILEAC
|| ||||...|.. ..      || ..  ... . ..|      ..|.. |||.||..|.||..
aGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 925-1143 2.2e-36 120.2 In-house 45-257 (267) alignment 
Range on Protein: 925-1143
Range on HMM: 45-257/267.0
YDRHRVklhpMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKlveVGRVKCSRYWPED---SDTYGDIKIMLVKTET
||  ||    .| . . .|||| |..||.. |.||.||.|    . ||. .. ..... ||..||   |.  .  ..||     .  | |. .     . 
yddtrv....ilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmgqakkyqdltvehsleke

LAEYVVRTFALERRGYSArHEVRQFHFTAWPEH--GVPYHAtGLLAFIrrVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKT
  .| . |. |. .  || |.|  ...  |       ||    |.. .   |        |.|..||.| ||.| ..|.| .|. |  |||.||.. .. 
endyqiitlelkfknesa.hnvtlyyykkwnintnnkpylk.plfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrk

LCSRRVNMIQTEEQYIFIHDAILE
. |.|. ...| |.||.||. . |
irsqriglvdtkeryiyihellae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1172-1441 2.9e-36 119.7 In-house 13-294 (301) alignment 
Range on Protein: 1172-1441
Range on HMM: 13-294/301.0
NSSQLREEFQTLNSVTPpldvEECSIALLPRNRDKN--RSMDVLPPDRCLPFLI-STDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDY
.| .. |....|.....    ..|.. |  .|.  |  ... |.. .| .     . |  ...||||   |.|... .||..  |...|  |||||....
hsnkfeeqykelkeged....ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

GCTSIVMLNQLNQSNSAWpCLQYWPEPGRQ--QYGLMEVEFMSGTADEDLVARVFRVQ--N------------ISRLQEGHlLVRHFQFLRWSAYRDTPD
  .||||. .|...  .  | ||||.   .  ..| ..|.... ..  | | | . |.  .            ... ....  |  .|   |      ..
kpvsivmvtnlkegtksk.ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdkssw.dvlqlqvtdWpqdGvvre

sKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
 ..  |. . .| . |   | |  .||| .. .|||..|.    ||  .    ||||   |..|  || .| |..|| . |||  .||.
.prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_PTPN1_pd Subfamily PTPN1 1195-1438 3.9e-36 119.3 In-house 24-269 (290) alignment 
Range on Protein: 1195-1438
Range on HMM: 24-269/290.0
CSIALLPRNRDKNRSMDVLPPDRCLpflISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWPE
.. | ||.||..||  || | | .    |  . ..|.||||.| .       .|.|  || .|.  ||..|..  . ..||||.. . ..   | ||||.
treaklpenrnlnryrdvspydhsr...ikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq.ikcaqywPq

PGRQQYG-----LMEVEFMSGTADEDLVARVFRVQNISRlQEGHlLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAES-GDGRTIVHCLNGGGRSG
  ...        ..|...|    .  . |.....|..  || .  . || ...|. .   |.|  |||..| .| .  . |   | ...||  | ||||
geeekellledtklkvkliseerksyytvrllelenlkt.qetr.eilhfhyttwpdf.gvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

TFCACATVLEMIRCHN---LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
|||   |.|  |  ..    ||.      ||.|.  .. |.|| .| |   ||
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051082 (Phosphotyrosine protein) phosphatases II 941-1142 1.2e-35 117.6 In-house 3-150 (151) alignment 
Range on Protein: 941-1142
Range on HMM: 3-150/151.0
ADYINANYIDGYhrsnhFIATQGPKPemvyDFWRMVWQEHCSSIVMITKLVEVGrvKCSRYWPEDSdtygdikimlvktetlaeyvvrtfalerrgysar
 ||||..|..|.     .....|| .    ||...........||......| |  .| .|.|| .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAstpPDAGPIVIHCSAGTGRTGCYIVLDVMLDMaecegvVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
.||...... ||..|.| .   .|.|.. . .   .. ||...||||| ||||. ..|. || .      |... ... . ..| ...|...|..|.. |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

IL
.|
ll
0046846 (Phosphotyrosine protein) phosphatases II 1221-1441 3.8e-35 116.6 In-house 3-174 (176) alignment 
Range on Protein: 1221-1441
Range on HMM: 3-174/176.0
FLISTDGDSNNYINAALTDSYtrsaAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWpCLQYWPEpgRQQYGLmevefmsgtadedlvarv
....... . .|||| | ...    ..|.| .|| .|..||.......|.| .|.|... . .. . | .||||   ...|.                  
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlk.cpnywpe..leklgi..................

frvqnisrlqeghllvrHFQFLRWSAYrDTPDSkKAFLHLLAEVDKWQAESgdGRTIVHCLNGGGRSGTFCACAtvleMIRCHNLVDVFFAAKTLRNYKP
                 ....| |  . ..||. ...|.||....... |   |...|||  | ||.||..|.     ...... ..|. | ...|...|
.................qylhlpwpDh.gvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-NMVETMDQYHFCYDVALEYLE
 ..|.|..||.|.|...|..|.
lgavqtpeQyrflyefellllk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 917-1144 5.6e-35 115.4 In-house 59-288 (305) alignment 
Range on Protein: 917-1144
Range on HMM: 59-288/305.0
SRQEPMPAYDRHRVKLHPmlgDPNADYINANYIDGYH-RSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIM
 | . .|. |.  |||.     . .||| |||.       . ||..|||  . . .|| || |..   |||. | ||.|..||..|||       ..|  
nryqdvpcqdqsavkldk...pspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg

LVKT--------ETLAEYVVRTFALERRGySARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTppdaGPIVIHCSAGTGRTGCYIVLDVMLD-MAE
.|          |  ||  . .. |   | . .  ||....| ||. |||      | ..  .. |      |||.||||| ||||  . .. .|. .||
ivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiae

CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
   .  . . ||.|  .|   ||.. ||.|||  .|. 
nkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_PTPN14_pd Subfamily PTPN14 1172-1441 6.8e-35 115.5 In-house 21-297 (300) alignment 
Range on Protein: 1172-1441
Range on HMM: 21-297/300.0
NSSQLREEFQTlnsVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSY--TRSAAFIVTLHPLQSTTPDFWRLVYDYG
.....  |..    ...     ..| | || | .|||  |||| . .   |..|  .|..||||.       ...  .||.  ||. |  |||..|.. |
eegkvfteyer...ipkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqg

CTSIVMLNQLNQsNSAWPCLQYWPEP----GRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHllVRHFQFLRWSAyRDTPDSKKAFLHLLAEVD
 . |||| . .. .    ...|.|.      . ..|  .|     .  . .... .... .   .|    | |.|.  |.  .. |.  | ||. | ||.
vqlivmlteeee.dgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeert..vwhlqytDWpd.hgvPeDvkgflsyLeevq

KWQAESGDGR--------TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
  . .. . .         .|||..|.||.|       ... . . . .|.  . ..||. .  .|.|. ||.| |.| ..||.
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 915-1143 8.1e-35 114.8 In-house 39-267 (281) alignment 
Range on Protein: 915-1143
Range on HMM: 39-267/281.0
KGSRQEPMPAYDRHRVKLHP-MLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIK
|  |   .|. |  ||.|.  |     .||| ||||        .| ||||| |   |||||.|||  ..|||. ...|  | ||. |.| ..    .. 
kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfd

IMLVKTETLAeyVVRTFALERRGYSARHE---VRQFHFTAWPEHGVPYHATGLLAFIRRVKAST-PPdagpiVIHCSAGTGRTGCYIVLDVMLDMAECE-
 . |. |  .  | ...   |   |   |   . .. .  ||.  ||  .  .|  .|...| . ||     ||||||| ||.|  . ... |.   .  
klsvsyedst..vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstpp.....vihcsagvgrsgtlmaveialqsihshf

GVVDIYNCVKTLC-SRRVNMIQTEEQYIFIHDAILE
 . || . |  |  . |   .|| .||..|   .|.
tlpdikqivshlrvtgraasvqtlqqymliwkvlld
0051429 (Phosphotyrosine protein) phosphatases II 1230-1443 1.3e-34 115.4 In-house 4-228 (272) alignment 
Range on Protein: 1230-1443
Range on HMM: 4-228/272.0
NNYINAALTDSYTR---SAAFIVTLHPLQSTTPDFWRLvYDYGCTSIVMLNQLNQSNSaWPCLQYWP------------EPGRQQYGLMEVEFMSGTADE
..||||   . |.|     ... . .||. |  ||||| ...|...||.| ...  ..  .| .|||            .. .  || . | ..| .  .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgr.lkcdrywpgirylhlpilddsaptilygalrvtllseelll

DLVARVFRVQNISRLQEGhLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEvdkwqaesgDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVD-------
| . |.... ...  .|. . |.|.....|  .   ... ...|.||..         .|. .|||  | .|.||..|.  .|. .  .  ||       
dyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGL
 .. | . || . |..|.| .||.|.|...||.|..|
yleeaveelraqrpgavqteeqylflyeallellrsl
0044763 (Phosphotyrosine protein) phosphatases II 925-1142 2e-34 114.1 In-house 2-168 (178) alignment 
Range on Protein: 925-1142
Range on HMM: 2-168/178.0
YDRHRVKLHPMLGDPNADYINANYIDGYhrsnHFIATQGPkpemvYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDtygdikimlvktetlae
.||.||.|... | . .|||||..|...     ......|      |............||..|. .| |..|| .||||. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yvvrtfalerrgysarhevRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMaeceGVvDIYNCVKTLCSRR
                    |.... .| ||||     .|.|.. ...  ... ||...||||| ||.|. .... |. .    |. ....... . .||
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerR

VnMIQTEEQYIFIHDAIL
  ......|. ....  |
p.ivpnpgqlrqLyefel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1196-1442 1.3e-33 111.1 In-house 13-266 (270) alignment 
Range on Protein: 1196-1442
Range on HMM: 13-266/270.0
SIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTD-SYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWP
..    |..  ||..|.||  .    | . . ||  .||||        .....| .  ||..|. .|||....   |.|||. .|.  .    | .|||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrk.kCerYWp

EPGRQ----QYGLMEVEFMSGTADEDLVARVFRVQnisRLQEGHLLVrHFQFLRWS--AYRDTPD---SKKAFLHLLAEVDKWQAESGDG-RTIVHCLNG
.   .    ..| ..|  .| . .|  ...  |..   .  | . || ||..  |   .   ..|   | .  |..|..| ... |  ..  ..||| .|
aepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

GGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
 ||.||. |  ......  .. |||    . ||......|....||.| | . .|| | 
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_ptpA1_pd Subfamily ptpA1 890-1102 1.3e-32 108.1 In-house 25-253 (418) alignment 
Range on Protein: 890-1102
Range on HMM: 25-253/418.0
EGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPaYDRHRVKLHPMLGDPNADYINANYIDGYHrSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK
| . . .|     |  .  ||..  |    . .|  .. ||.|. .     .|||||||||| .  ..||.|||| |. . |||||||...|  |||...
eefrlleesvgpsetsegdkkhntsknrytnilp.vnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsr

LVEVGRVKCSRYWPEDS------------DTYGDIKIMLVKT--ETLAEYVVRTFALERRGysARHEVRQFHFTAWPEHGVPYHATGL---LAFIRRVKA
  |  |.|| |||||.             . .|   . ||.   .   | . |   |   |    ... |...  ||.| .| |.  .   |  |   . 
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

STPP---DAGPIVIHCSAGTGRTGCYIVLDVML
   |      ||..||||| |||| .    .|.
qiipssdrnvpiivhcsagvgrtgtfctavimm
0043147 (Phosphotyrosine protein) phosphatases II 1228-1434 5e-32 106.4 In-house 3-155 (172) alignment 
Range on Protein: 1228-1434
Range on HMM: 3-155/172.0
DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLnqsnsawpclqywpepgrqqyglmevefmsgtadedlvarvfrvqnIS
....|||| . | |     ||.|. ||..|..||||.....|.| ||.|..|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

RLQEGHLLVRHFQFLRWSAYRDTpdSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLemircHNLvDVFFAAKTLRNYKPNMVETMD
  .  . |. ....| |  .  .  . . .|..|  .|...|.| .|...|||  | ||.||..|.  .|     ..| ... | ...|. .|..|.. .
dpellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnps

QYHFCYD
||.|.|.
qyrflyy
PTPc_DSPc_SM00012 1043-1143 1.6e-31 104.0 In-house 2-105 (105) alignment 
Range on Protein: 1043-1143
Range on HMM: 2-105/105.0
VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDA--GPIVIHCSAGTGRTGCYIVLDVMLDMAECE-GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD
|...|.|.||.|||| ... .| ..| || ..   .  .|.|.||||| ||||....||..|.. | | . |||...|| | ..| .|.||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 919-1142 5.1e-31 102.4 In-house 58-287 (310) alignment 
Range on Protein: 919-1142
Range on HMM: 58-287/310.0
QEPMPAYDRHRVKLHpMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED--SDTYGDIKIML
   .   |  ||||. .      ||| |||.   .  . || .|||    . |||||..|| . ||... | .| || ||  |||    ..||| |..  
ysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtn

VkTETLAEYVVR----TFAL------ERRGYSARHEVRQFHFTAWPEHGVPYHATGllAFIRRVKASTppDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE
. .|.  |. .     ||        |.        |   ..  ||. |||       .  .|. |      || |.||||| .|... . |.. .| ..
l.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkld

CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
    ||. . .  |  .|.  |||| ||..|.   .
rglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1203-1439 9e-31 101.7 In-house 38-276 (287) alignment 
Range on Protein: 1203-1439
Range on HMM: 38-276/287.0
NRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQlNQSNSAWPCLQYWPEPGRQ-QYG
.  |||  |||| |    .|  .     .||||    |||.  |||..  |. .|  ||||.|..   .|.... . .  ..   | .||||. .  . |
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr.eveearlkcykywPerevPmrvG

LMEVEFMSGTA-DEDLVARVFRVQNISRlQEGHlLVRHFQFLRWSAYRDTPDSkKAFLHLLA----EVDKWQAESGDGRTIVHCLNGGGRSGTFCACATV
   |  .. .  . .   | .|. ..   .| . .|. ...| | .   .| .  ... .       ..  .  |. |  .||.  | ||||.. |  ..
GysvvlldydikePeygvralrlidlet.rear.vvkqldllswPdkvlaPta.vglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
...      |||  .   ||.|.  .| .. |. . |.    |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1171-1439 9.3e-31 101.7 In-house 17-278 (439) alignment 
Range on Protein: 1171-1439
Range on HMM: 17-278/439.0
SNSSQLREEFQTLNSVTPPLDVEeCSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGD-SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG
 .   ..|.|...||. |.  .. .|.|    .. |||  || . |     |  . |     ||||   . |     .| |  | . || ||||||..  
nkqeifkeifekinstspdyaci.aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

CTSIVMLNQLNQSNSawpclqYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQA
.. |||| .| .|        |||  .   || . |         . | | |.| |     |    | .|... |   .. |      |..|  ..  . 
tvtivmltnlvesyk......ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpd.knvpaqashvldflrainsand

ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
.   |  .|||  | ||.||  |    || ..  | ||.    | ||. . .||... || | |.  || 
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1174-1442 1.7e-29 97.7 In-house 6-261 (267) alignment 
Range on Protein: 1174-1442
Range on HMM: 6-261/267.0
SQLREEFQTLNSVTPPLDVEECSIAllPRNRDKNRSMDVLPPDRCLPFLISTDGDsnnYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
 ....||. .. ...      .|||    |...||  |.|| |     |  .. .   ||||.  ..| .  |||||  ||. |  ||. .. |.... |
ceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNQLNQSNSAwpclQYWPEP--GRQQYGLMEVEFMSGTADEDLVarVFRVQNISRlQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAevdKWQAES
|.| .  . |      ..||      ..|  . ||.     ..|    .  ..   . .|    |  . . .|    .     | .. .||   | | | 
vlltkvftdnir....lfwPPkmgqakkyqdltvehslekeendyq..iitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgila...knqlen

GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
|.   .|.| .| ||||||    . || ..  . .|.|   . .|. .. .|.|...| .....  || ||
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 918-1144 2.9e-29 97.0 In-house 48-270 (288) alignment 
Range on Protein: 918-1144
Range on HMM: 48-270/288.0
RQEPMPAYDRHRVKLHpmlgDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIML-
| | .|  |  ||||.    |    ||.|| .   .  ...| .| |    .  .|.|. ..    |||...|.| |. |   |.|        |. .  
ryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlct

---VKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTppdaGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDI
   .| . .   |. .     .    .  |.. |.  |...|||      | .. ..|. .     |||.|.|||.||||  |.  ..|...  .  . |
vvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialeslrlddflgi

YNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
 . .. |   | . |||| ||...|  .|| 
rsllaklreerfkaiqtemqylyvhrcvlee
0049260 (Phosphotyrosine protein) phosphatases II 1239-1434 1.4e-27 91.7 In-house 3-144 (152) alignment 
Range on Protein: 1239-1434
Range on HMM: 3-144/152.0
DSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWpepgrqqyglmevefmsgtadedlvarvfrvqnisrlqeghllvrh
| | .. .|| |..|.  |..||||.....|.| ||||..|   .    | ||.                                              
dgyampfefiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi..............................................

fQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLemirchNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD
 |.|..    ... .   .|  | ..... |.. .|...|||  | ||.||..|.  .|      . |... | . .|. .|..|.. .|. |.|.
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 944-1136 1.6e-27 91.0 In-house 78-272 (301) alignment 
Range on Protein: 944-1136
Range on HMM: 78-272/301.0
INANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE---TLAEYVV--RTFALE-RRGY
| ||.|.   ....||||||| ..  .||| |. | .   |||... ||    ||. | | .     ||.   .|..   .. .  .  ||. .|   | 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

SARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTppdaGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF
 | . |  . .. |...|||   . |  ..  || |      |||.||||| ||. ..|  ...    | .  ... . .| |  .| | .||..|  .
fatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 905-1066 1.7e-27 91.0 In-house 25-189 (297) alignment 
Range on Protein: 905-1066
Range on HMM: 25-189/297.0
WDATKKKDKVKGSRQEPMPAYDRHRVKLHPmlGDPNADYINANYIDGY--HRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW
. ..|..  ..  |   . |.|  ||||    . .. |||||.|.     .   ..| .|||  . | |||..|...    |||..|| | || ||  ||
fssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PEDS---DTYGDIKIMLVKTeTLAEY---VVRTFALERRgySARHEVRQFHFTAWPEHGVPYHATGLLAF
|.      . ||. .  . . |  |.   ..  . |  |  | .  ||   | .||.||||     |  |
psvvqerlkagdvvveflss.tsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1202-1438 3.5e-27 90.2 In-house 2-237 (237) alignment 
Range on Protein: 1202-1438
Range on HMM: 2-237/237.0
RNRDKNRSMDVLPPDRCLPfLISTDGDSNNYINAALTDSYT-RSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGR-QQ
.|. |||  ..   | .   ..   | . .||||.  ...      .| .  ||.|.  |||..|..  |. ||||  | ..|    | .|||.  . . 
enkiknrygnivaydhsrv.vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnel.kchkywpstdqpaa

YGLMEVEFMSGTADEDLVARVFRVQNISRLQEgHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEV-DKWQAESGDGRTIVHCLNGGGRSGTFCACATVLE
|| . | .    .  |   | . ...  .|.|   |.  .||  |   |  |.   |.| .  .. .. .  |  |  |.||  | ||.| |    ..| 
ygvltvslkkkeefsdytvrslllskrltlke.vrlihqyqftswp.drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
  . ...||..   ... . .| ...| ||| | ... ||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1042-1182 5.6e-27 89.1 In-house 90-231 (440) alignment 
Range on Protein: 1042-1182
Range on HMM: 90-231/440.0
EVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTP-PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
 ..|.|. .||..|||  |  .| .|. |. |      ||...|||||.||||  |..| .|  |.    .||.. .... . | .|.|| ||| |.|.|
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQT
.||. |||.| |   .     ...   .|... | |..||. 
vlegllcgdtliledditerveqiqwpnphtdksplqqefeg
subfamily_egg_pd Subfamily egg 912-1142 3.1e-26 86.8 In-house 39-267 (307) alignment 
Range on Protein: 912-1142
Range on HMM: 39-267/307.0
DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVgrVKCSRYWPE---DSDT
.. . .|.. ..  |  ||||.   |    |.| ||...|    |.|| .| |  . | ||||||.||..  |||.|  .|    .|  |||    ||  
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

Y--GDIKIMLVKTETLAEYVVRTFALERRGYSaRHEVRQFHF-TAWPEHGVPYHATGLLAFIRRvkASTppdagPIVIHCSAGTGRTGCYIVLDVMLdMA
.  | ..|  .| .  |. . |   |   |   . |    |.   . . .  |    .|  .|.  .|.     |.|...  |  .... . ... | . 
tvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqgdvnnssdvysplrvlrklrn..lsk.....pvvvqdilGvskaatlvaieial.ls

ECEGV---VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
   |      . ..|. |  ||   ...  .|.|..  .|
llrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 938-1149 1.4e-25 84.9 In-house 56-273 (285) alignment 
Range on Protein: 938-1149
Range on HMM: 56-273/285.0
DPNADYINANYID--GYHRSnHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD---TYGDIKIML--VKTETLAEYVVRTF
. . ||| |...   |  .|  .|.|||| || . |||.|..||. . ..|.  |.| |  ||. |.||       .|  .| |  .| |..|  .. ..
nhdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnal

ALERRGYSARHEV--RQFHFTAWPEHGVPYHATGLLAFIRRVKASTPpDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMI
..     ..   .   . .   ||..  |  |  .. . . ||   |    ||..||||| |||  .. .|        .  ... . |. . . |.. .
tvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqav

QTEEQYIFIHDAILEAcLCGE
|.  |..|..  ..|  . ||
qshmqflflyvvlmey.fige
0051082 (Phosphotyrosine protein) phosphatases II 1230-1436 1.4e-25 85.1 In-house 3-149 (151) alignment 
Range on Protein: 1230-1436
Range on HMM: 3-149/151.0
NNYINAALTDSYtrsaaFIVTLHPlqstTPDFWRLVYDYGCTSIVMLNQLNQSNsawPCLQYWPEPGrqqyglmevefmsgtadedlvarvfrvqnisrl
..|||.   ...     .... .|    ..||..|....|...||.|...   .    | .|.|| |                                 
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg...ycpeylpelg.................................

qeghLLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKwqaeSGDGRTIVHCLNGGGRSGTFCACATVLEMirchnlVDVFFAAKTLRNYKPNMVETMDQY
    . |.|...| |... ..|.| .|.|..| ....     ..| ..|||  | ||.||..|.  .|..      |... | . .| . |..| ...|.
....ievlhipildwpdp.glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

HFCYDVA
 |.. . 
lfqlfal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1239-1435 1.9e-25 84.1 In-house 230-433 (440) alignment 
Range on Protein: 1239-1435
Range on HMM: 230-433/440.0
DSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsawpCLQYWPEPGRQ-QYGLMEVefmsGTADEDLVARV-FRVQNISRLQEGHlLV
. |..  ||| |  ||.||  ||||||.||  ..|.||||||.      |  |||   |   .| . |    |    . . ||  |  ..   .| |  .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt....csiywpvntrsvtfgpftv....ghkgsenmnrvkvrtlelkykeevh.ei

RHFQFLRWSAYR--DTPDSK----KAFLHLLAEVDK-------WQAESGDGRTI-VHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNM
| |.   | ..   |  .|.     | | |.  . |        |.  |||  | |||| |   || ||.   .|| .     .|||   . ||  .||.
rqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnf

VETMDQYHFCYDV
| |. .| .|| .
vptltdyllcykl
subfamily_CG42327_pd Subfamily CG42327 928-1073 1e-24 81.8 In-house 43-193 (319) alignment 
Range on Protein: 928-1073
Range on HMM: 43-193/319.0
HRVKLHPMLGDPNADYINANYIDGYHRS-NHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-----DSDTYGDIKIMLVKTET
 || |. .  |..  |..|.|. ||. . |..||.| .  .   ||||.||.     || .|.| | |  .|..|.|      . ..||||.. | . |.
trvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev

LAEYVVRTFALERRGYSARHEVRQFHFtAWPEHGVPYHATGLLAFIRRVKAS
  .|.. |. | |   .   |.  . .  |.| .|| . . |.| . .|..|
kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1197-1439 6.3e-24 79.4 In-house 27-294 (297) alignment 
Range on Protein: 1197-1439
Range on HMM: 27-294/297.0
IALLPRNRDKNRSMDVLPPDRCLPFLISTDGDsNNYINAALTD--SYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLnQSNSAWPCLQYWPE
 |  .    |||  |.|  |     |  .  . ..||||             .|..  ||..|  |||.||.. .   |||. .| | .    |  |||.
sakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvakl.qedGrdkcapywps

--PGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRlqEGHLLVRHFQFLRWSAYRdTP----DSKKA-------------FLHLLA--------EVDKW
   .|.. | . |||.| |.||     .  .| | |  . .  ||| ||| |  .   |    | ..              .| |.         ...  
vvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

QAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
.||   .  ..|||  | ||||    . ..|...| . . ||    . ||. .. .|.|..|....||..|. 
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
0048076 (Phosphotyrosine protein) phosphatases II 1019-1142 7.4e-24 79.5 In-house 22-140 (145) alignment 
Range on Protein: 1019-1142
Range on HMM: 22-140/145.0
TETLAEYVVRT-FALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDaGPIVIHCSAGTGRTGCYIVLDVMLDmaecEGvVDIYNCV
 |.|... ..| . | .  .   ... |.... || ||||  .  ||.|.. ...  . . ||...||||| ||||.......||     .| |......
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KTLCSRRVNMIQTEEQYIFIHDAIL
. . |.| .......|..|.....|
elvrsqrpgavpnpgqlrflyefel
PTPc_DSPc_SM00012 1336-1438 2.1e-23 77.9 In-house 2-105 (105) alignment 
Range on Protein: 1336-1438
Range on HMM: 2-105/105.0
VRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCH-NLVDVFFAAKTLRNYKPNMVETMDQYHFCY
|.|.... |.    .|.. ...|.||..|.|.. .|.  . ..||| .| ||.|||.| ...|.... . . ||.|   | ||...|.||.| .|| |.|
vkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DVALE
.. ||
ralle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1203-1438 2.4e-23 77.6 In-house 7-238 (239) alignment 
Range on Protein: 1203-1438
Range on HMM: 7-238/239.0
NRDKNRSMDVLPPDRCLPFL--ISTDGDSnNYINAALTDSYTRS-AAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWPEPGrQQ
|. |||  ...  |.    |  .| |  | .||||.    |  |  |.| |   .. .. ||||....     ||||  | .      | ||||.    .
nkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk.kkchqywpdst.sk

YGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLvrHFQFLRWSAyRDTPDSKKAFLHLLAEVDKwQAESGDGRTIVHCLNGGGRSGTFCACATVLEM
|  . | .       | . | | . .. . .| ..   ...|  |   .  |.   | | |  .. | ..  |    ..||  | ||.|.|    ..|  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvy..qyhftvwpd.kgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrq

IRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALE
 . .. ||.|   |..|. .| ||.| .|| | .   ||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
0048179 (Phosphotyrosine protein) phosphatases II 1025-1139 2.6e-23 77.8 In-house 31-139 (144) alignment 
Range on Protein: 1025-1139
Range on HMM: 31-139/144.0
YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDaGPIVIHCSAGTGRTGCYIVLDVMLdmaeCEGvVDIYNCVKTLCSRR
. | ... |.  ..  .|. |.... || |||| ... ||.|.. ...  ... ||...||||| ||||.......|.    ..| ........ . |||
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

VNMIQTEEQYIFIHD
 .......|..|...
pgavpnpgqlrfLle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1203-1437 2.8e-23 77.3 In-house 8-238 (239) alignment 
Range on Protein: 1203-1437
Range on HMM: 8-238/239.0
NRDKNRSMDVLPPDRCLPFL--ISTDGDSnNYINAALTDSYTRS-AAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWPEPGrQQ
|. |||  ...  |.    |  .| |  | .||||.    |  |  |.| |   .. .. ||||....     ||||  | .      | ||||.    .
nkaknryanivtydhsrvvleklsndphs.dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk.kkchqywpdst.sk

YGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLvrHFQFLRWSAyRDTPDSKKAFLHLLAEVDKwQAESGDGRTIVHCLNGGGRSGTFCACATVLEM
|  . | .       | . | | . .. . .| ..   ...|  |   .  |.   | | |  .. | ..  |    ..||  | ||.|.|    ..|  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvy..qyhftvwpd.kgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrq

IRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL
 . .. ||.|   |..|. .| ||.| .|| | .   |
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
0044763 (Phosphotyrosine protein) phosphatases II 1254-1439 3.9e-23 77.4 In-house 37-170 (178) alignment 
Range on Protein: 1254-1439
Range on HMM: 37-170/178.0
LqsttPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCLQYWPEPGRqqyglmevefmsgtadedlvarvfrvqnisrlqeghllvrhFQFLRWSAY-RDTPD
     .|...|....|.|.||.|..    .  ..|..||||                                            .|.|..     ..||
p....addlellkelgithivnlteelelg.flkcdpywpeeag.........................................iqylhipipDhgvpd

SKKAFLHLLAEVDKWQAESGdGRTIVHCLNGGGRSGTFCACATVLEMirchNLvDVFFAAKTLRNYKPnMVETMDQYHFCYDVALEY
. . || ... ......|.| |...|||  | |||||..|.  ....    .| ... | . .|...| .|....|....|...|..
llehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1174-1439 2.3e-22 74.0 In-house 27-282 (290) alignment 
Range on Protein: 1174-1439
Range on HMM: 27-282/290.0
SQLREEFqtLNSVTPPLDVEECSIALLPRNR--DKNRSMDVLPPDRCLpfLISTDGDSNNYINAALTDSytRSAAFIVTLHPLQSTTPDFWRLVYDYGCT
 .|  |.  |. . | | |.     .. .|    |||  ||   |.    .|  ||   .|. |   .     | ||.|  .|..|. |.||.| . . .
delakey..leklkpylpvqylerkifdkntefkknrykdvvcndktr..vilkdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekva

SIVMLNQLNQSNSAwPCLQYWPEPGRQQ--YGLMEVEF-MSGTADEDLVARVFRVQNISRLQEgHLLvRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWq
 |||| .| .   |  | ||.||   .   .| . |   .. . |.... ... |..    .| | | .|..   |   .  . |. |.| .|  . |  
aivmlceliedGka.kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke.hkl.khlkikswpd.ksvalstlallrtlrilrka.

aesgDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
     |  .|||  | ||.||| |  . |...     .|.    ..||| . | |.   ||    .. |..
....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1173-1440 4.5e-22 73.4 In-house 15-277 (307) alignment 
Range on Protein: 1173-1440
Range on HMM: 15-277/307.0
SSQLREEFQTLNSVTPpldvEECSIALLPRNRDKNRSMDVLPPDRClPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTS
 ..|..||. |   ||    |  ..  .  | ||||  ||   |..   .. .|| . .|| |      ..   ||..  ||..|  .|| .. .    |
vqalvdefrvlakktp....egvtveafsantdknryqdvkcqdkg.rivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMLNQLNQSNsAWPCLQYWPEPGRQQYGLMEVEFMSGTAD--EDLVARVFRVQNISRLQ----EGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDK
..|| .. .      | ||||    |.    |       |.   . .|    . |.. |.    ..   ..|.|.  |   | .|. . . . ||  |  
vimlckviela.kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd.rgvpqinltainlleavry

WQaesgdGRTIVHCLNGGGRSGTFCACATVLE-MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .        .|||  | |||||  | . | . ||.  |  |.    . ||. ..  ..|  || . . | |||.
dt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 911-1142 5.7e-22 72.5 In-house 49-282 (302) alignment 
Range on Protein: 911-1142
Range on HMM: 49-282/302.0
KDKVKGSRQEPMPAYDRHRVKLHpmlgDPNADYINANYIDGYHRSNHFIATQGPKPEMV---YDFWRMVWQEHCSSIVMITKLVEVGRvKCSRYWPEDSD
|...| ...| .|..| ..|||.      . .|.||  ..  . ..  | .| || ...    .|||||.||.. |.|.. .  |. .   | ..|. |.
kknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

TYGDIKIMLVKTET---LAEYVvRTFALE--RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVML
.| . . | | .       | .   ...|    |.|    .   ..| |... || . . | . .  | |.. .   ..||    |.|| |  ..| | .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
.  . .  . | . ||.. | | ..... .||.... |.|
eklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1176-1439 3.7e-21 70.0 In-house 13-268 (281) alignment 
Range on Protein: 1176-1439
Range on HMM: 13-268/281.0
LREEFQTLNSvTPPLDVeeCSIALLPRNRDKNRSMDVLPPDRC--LPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
...||  |    || |.  |..   | |  ||| ...   |       .   . .| .|| |    |      .|.|  | . |  ||||....   |.|
fkqefsnlpg.dppsdl..ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMLNQLNQSNSAwPCLQYWPEPGR--QQYGLMEVEFMSGTADEDLVARVFrvqNISRLQEGHlLVRHFQFLRWSAYRdTPDSKKAFLHLLAEVdkwQAES
||| |. ..|    | .|.|   .   |.  . |..   | .. ||.  .   |.|   | . |. |. .  |  ..  |.| . .|..| ..   .| |
vmlcqfletnre.kcaeyfprnahcclqfdklsvsyedstvnkslvttrl...nlsyegetr.lithwlwkewpdwq.vpessevmlkilrki...rars

GdgRTIVHCLNGGGRSGTFCACATVLEMIRCH-NLVDVFFAAKTLRN-YKPNMVETMDQYHFCYDVALEY
     ..||  | |||||. |    |. |..|  | |.      ||   .   |.|..|| . . | |..
t..ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 956-1138 5.8e-21 69.6 In-house 5-197 (199) alignment 
Range on Protein: 956-1138
Range on HMM: 5-197/199.0
NHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETL---AEYVVRTFALERRG--YSARHEVRQFHFTA
 ..|||| |  | . |||.|||.     |||.        .  . |||    . |    . | |.|.   ..|.. .. |        .  |. .. ||.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEHGVPYHA--TGLLAFIRRVKA-STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC--EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIH
| |.  |  |   |..   | |          |...||| | | || .. ||. .   |     |||...  | |   |. .| . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 956-1138 6.3e-21 69.4 In-house 4-196 (198) alignment 
Range on Protein: 956-1138
Range on HMM: 4-196/198.0
NHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETL---AEYVVRTFALERRG--YSARHEVRQFHFTA
 ..|||| |  | . |||.|||.     |||.        .  . |||    . |    . | |.|.   ..|.. .. |        .  |. .. ||.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEHGVPYHA--TGLLAFIRRVKA-STPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC--EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIH
| |.  |  |   |..   | |          |...||| | | || .. ||. .   |     |||...  | |   |. .| . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 920-1163 7.3e-21 69.5 In-house 25-269 (290) alignment 
Range on Protein: 920-1163
Range on HMM: 25-269/290.0
EPMPAYDRHRVKLHPMLGDPNADYINANYIDgYHRSNHFIATQGPKPEM-------VYDFWRMVWQEHCSSIVMITKLVEVGRV----KCSRYWPEDSD-
...|     || |.      | ||| ||..  .    ..|.|| |. ..       . .|| |. ||.  ..||. .  |  .      |..| ||  . 
levpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

--TYGDIKIMLVKTETLAEYVVRTFALERRGySARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTppdaGPIVIHCSAGTGRTGCYIVLDVMLDM-
  .......   . |.  .  .|.  ..  .    . |    .  | .  |. .   ||. |. ||||.     |...||  |  |  .   ...   . 
elkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQki

AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILeaclcgettIPVSEFK-ATYKE
|| .| | . . .|.| ..| ..|...... |.  .|.         . . |.. ....|
aetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqfaee
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 923-1145 1.8e-20 67.9 In-house 53-276 (312) alignment 
Range on Protein: 923-1145
Range on HMM: 53-276/312.0
PAYDRHRVKLhpmLGDPNAdYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWpEDSDTYGDIKIMLVKTETL
  .|| |  |    || |  || ||..    . ..|..||||  . .  ||...    ..||.... .|| |  ||..|   |  .. |..   | ||  
qcwdrgrftl...agdenf.yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi.sdivgfvdledhrvyteyc

AEYVVRTFA----------LERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAstppDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD
.|  .   .          .  .       . .. ...||.||.|      | ..  ||     |  |.. ||||| ||||  .... |.         .
teieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaalrhprkqn

IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
. .    |   |   ...  ||..   ..||  
vkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1246-1435 2.9e-19 64.0 In-house 5-198 (198) alignment 
Range on Protein: 1246-1435
Range on HMM: 5-198/198.0
AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQlNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLR
 .|.| |||. |  |||..|.. |   |||.|. .| |       |||  | |  .|| . |   . |.  | .  .. . | .        . |.||  
ryiatqhplretladfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSAyRDTPDSKK--AFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMI--RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV
|   . ||.      |.    || |   .  |   |||| .| | .| | |    .         .||.|  || ||. .  .. ....| | |.|
wke.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1246-1435 3e-19 64.0 In-house 6-199 (199) alignment 
Range on Protein: 1246-1435
Range on HMM: 6-199/199.0
AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQlNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLR
 .|.| |||. |  |||..|.. |   |||.|. .| |       |||  | |  .|| . |   . |.  | .  .. . | .        . |.||  
ryiatqhplretmadfwqmvwetgsghivmvnd.dqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSAyRDTPDSKK--AFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMI--RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV
|   . ||.      |.    || |   .  |   |||| .| | .| | |    .         .||.|  || ||. .  .. ....| | |.|
wke.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 969-1162 3.2e-19 64.0 In-house 41-232 (255) alignment 
Range on Protein: 969-1162
Range on HMM: 41-232/255.0
VYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIK-IMLVKTETLAEYVVRTFALERR-G-YSARHEVRQFHFTAWPEHGVPYHATGLLA
|  |.... |   . .||.. . | |..|||.|.| . |    .. . .. |.. |. |.||  .    |     |.|. .... |.|.  |  |  .| 
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareiln

FIRRVKASTppdagPIVIHCSAGTGRTGCYIVLDVMLD-----MAECEGV-VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAClcgettIPVSEFKA
 .. |. |      ..|.|||.| ||.  ... ...       . . | | .|  . .. | |.|   |.|  |  |    .|.         | .|..|
ilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkgelea

TYK
 |.
kyq
subfamily_ptpA1_pd Subfamily ptpA1 1175-1397 1.1e-18 62.2 In-house 22-253 (418) alignment 
Range on Protein: 1175-1397
Range on HMM: 22-253/418.0
QLREEFQTLNSVTPPLDVEECSialLPRNRDKNRSMDVLPPDRCLPFLI-STDGDSNNYINAALTDSyTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
...|||. |.    | .  |       .|  |||  ..|| ..    |    | . ..||||   |  .    ||.|  ||  |  ||||.|..  |  |
kikeefrlleesvgpsetsegd...kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcrii

VMLNQlNQSNSAWPCLQYWPEP-GRQQYGLME-VEFMSGTADEDLVA------RVFRVQNISRLQEGHL-LVRHFQFLRWSAYrDTPDSKKAFLHLLAEV
|||.. .  |    | .||||  | .|. .    . . ||   .||       |    .||    ||    . ..|.  |  . . ||  . | .||  .
vmlsr.esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdh.nipdhtqpfrqllhsi

DKWQAE---SGDG--RTIVHCLNGGGRSGTFCACATVL
 . | .   | |     ||||  | ||.||||..  ..
tnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
0048076 (Phosphotyrosine protein) phosphatases II 1334-1439 1.2e-17 59.4 In-house 45-142 (145) alignment 
Range on Protein: 1334-1439
Range on HMM: 45-142/145.0
LLVRHFQFLRWSAYrDTPDSKKAFLHLLAEVDKWQAESgdGRTIVHCLNGGGRSGTFCACAtvleMIRCHNlVDVFFAAKTLRNYKPNMVETMDQYHFCY
 |. ....| |  . ..||. . .|..|. ......|   |...|||  | ||.||..|.     ...... |... | . .|.. |..|....|..|.|
rlgiqylylpwpDh.gvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrfly

DVALEY
.. ||.
efelel
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1174-1440 1.9e-17 57.9 In-house 24-289 (305) alignment 
Range on Protein: 1174-1440
Range on HMM: 24-289/305.0
SQLREEFQTLNSVTPPLDVEECSIALL--PRNRDKNRSMDVLPPDRCLPFLISTDgdSNNYINAALTDS-YTRSAAFIVTLHPLQSTTPDFWRLVYDYGC
 .|||||. |   | |   .    |      .  |||  ||   |. .  |        .|| |            ||..  ||. |  .|| .| .   
dklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

TSIVMLNQLNQSnSAWPCLQYWPEPGRQQY---GLMEVEFMSGTADEDLVARV-FRVQNISRLQEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDK
  |||| .  .    . | ||||    ..    . . || .||.   .  | .   . |..   . .. |||.|.  |   |  |  | . | ||. .  
eqivmlcktvel.gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpd.rgvppckltslellsairg

WQAesgdgRTIVHCLNGGGRSGTFCACATVLEMIRCHNLV-DVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .        .|||  | ||.||  |   .|| |   . .  .    |.||. .   ...  || | . | |.|.
skv.....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1196-1430 2.8e-17 57.4 In-house 45-271 (301) alignment 
Range on Protein: 1196-1430
Range on HMM: 45-271/301.0
SIALLPRnrDKNRSMDVlPPDRCLPFLISTDGDSnNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPEP
| | ||.  ||.|   | | .      . .||     | |   ..  ..  ||.|  ||..|. ||| ..  |    |||| |  . .    | .| |  
syaylpk..dkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve.kleekceeylpvk

GRQQYGLMEVEF----MSGTADEDLVARVFRVQNISRLQEGHLlVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKwqaeSgDGRTIVHCLNGGGRSGTFC
 ...  .   .     .    ..... | ..|.. ..  . .  | |.|. .|.. |..| |.    .|.  | |    | .   .||| .| ||| .| 
isekldigrfkikiknkelilnkkiskrtlevedstgkfatrt.vthyqysewtd.rgvPkshaelfdlmelvkk....s.ekPivvhcsaGiGrsvafi

ACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH
.   .   .  .. ...  | | ||. . | | |  | .
gteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1225-1440 3.8e-17 57.2 In-house 62-271 (288) alignment 
Range on Protein: 1225-1440
Range on HMM: 62-271/288.0
TDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQQYGLMEVEFM--SGTADEDLVARVFR
 . |.. ||.| .  |      .| .  ||..|   .|... . .   ||||..| .        .|.|    ..  .  .  .     || | . .|  
lsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke.ksaeyfPsklGekarigrlctvvkkkradidklvkvsl

VQnISRLQEGHLLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVdkwqaESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNM
.. ||.  | . .|..  .| |      |.. ...|.||  .     .| .   .||. .| ||.||.     .||..| .. . .    . ||. . . 
lr.iskegeekvivkilhlleWdd.dgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka

VETMDQYHFCYDVALEYL
..|  || . . . ||.|
iqtemqylyvhrcvleel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 925-1016 4.2e-17 56.9 In-house 59-162 (350) alignment 
Range on Protein: 925-1016
Range on HMM: 59-162/350.0
YDRHRVKLHPMLGD--------PNADYINANYIDGY----HRSNH--FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSdtYG
|.. ||||.  |             |||||||.       .      .||||.| |. | ||.... . .   |...|..|| .. || |||.| |  | 
YehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs..yd

DIKIML
||.. |
ditvkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1081-1146 6.2e-17 55.8 In-house 1-66 (69) alignment 
Range on Protein: 1081-1146
Range on HMM: 1-66/69.0
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL
.|.|||.|||||| .| . | .     | .|||.| |. .   |  |.  | .|||||||. ||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
0048179 (Phosphotyrosine protein) phosphatases II 1335-1434 6.6e-17 57.0 In-house 48-139 (144) alignment 
Range on Protein: 1335-1434
Range on HMM: 48-139/144.0
LVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKWQAesGDGRTIVHCLNGGGRSGTFCACAtvleMIRCHNlVDVFFAAKTLRNYKPNMVETMDQYHFCYD
 . ....| |   ...||. . .|..|. ......   .|...|||  | ||.||..|.     ...... .... | . .|.. |..|....|..|...
egiqylhlpwpD.hgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1082-1147 2.1e-16 54.0 In-house 1-66 (69) alignment 
Range on Protein: 1082-1147
Range on HMM: 1-66/69.0
VIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC
|.|||.|||||| .| . | .     | .|||.| |. .   |  |.  |..|.|||||. ||   
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1172-1440 3.1e-16 53.9 In-house 17-276 (312) alignment 
Range on Protein: 1172-1440
Range on HMM: 17-276/312.0
NSSQLREEFQTLNSVTPpldVEECSIALlpRNRDKNRSMDVLPPDRCLpflISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCT
   ||  |....  . .     ||.  |  . .| ||  ..   ||     ..  || | || | .    |.   |..|  ||..|.  ||.|.   |.|
tpqqltkeykavgnivs...dsectafl..kfkdlnrypniqcwdrgr...ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgst

SIVMLNQLNQSNSAwPCLQYWPEP-------GRQQYGLM--EVEfMSGTADEDLVARVFRVQNISRLQEGHLlvRHFQFLRWSAYrDTPDSKKAFLHLLA
||..|  . .  |   | .|  .          . |  .  |.| . | . . .  ||..|   .  || .|   |.|.  |  .   |||  . | ||.
siillcgfvedgse.kcakyisdivgfvdledhrvyteycteie.iggkskdkithrvlkvvvkatgqeskl..nhyqwaswpdh.gmpdscdtalrlls

EVDKWQAesgdgRTIVHCLNGGGRSGTFCACATVLEMIR---CHNLVDVFFaakTLRNYKPNMVETMDQYHFCYDVALEYL
 | | .        | ||  | ||.||..   ...  .|     |. |.|     ||. .   |... || ..  . ||.|
avkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfv...llrkdrarsvrvfpqyvyalrcvlefl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 950-1052 8.1e-16 52.4 In-house 230-329 (440) alignment 
Range on Protein: 950-1052
Range on HMM: 230-329/440.0
DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEvgrVKCSRYWPED--SDTYGDIKIMLVKTETLAEYVVRTFALERRgySARHEVRQFH
.|| . | ||||| |    | ||||.| . . |.|.|. .| .     || ||| .  | |.| . .    .| .    |||. |  .     ||.||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk..eevheirqfe

FTAWP
  .||
vqtwp
subfamily_hpo-7_pd Subfamily hpo-7 969-1145 1.3e-15 52.0 In-house 47-227 (263) alignment 
Range on Protein: 969-1145
Range on HMM: 47-227/263.0
VYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIK-IMLVKTETLAEYVVRTFALERR-G-YSARHEVRQFHFTAWPEHGVPYHATGLLA
.  |.... |   . .||..   | |..|||.|.| . |    .. . .. |..  . ...|  |    |     |.|... .. |.|.  |  |   | 
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareiln

FIRRVKASTppdagPIVIHCSAGTGRTGCYIVLDVMLD-----MAECEGV-VDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
 .. .. |      ..|.|||.| ||.  . | ...       . . . | .|  . .. | |.|   |.|  |  |    .|.  
ilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 962-1141 3.5e-15 50.2 In-house 97-284 (302) alignment 
Range on Protein: 962-1141
Range on HMM: 97-284/302.0
QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDT---YGDIKIMLVKT-ETLAEYV----VRTFALERRGY----SARHEVRQFHFT
  || . .  .| .. | . . .| ....|| .  ||. |. .. .    .|   .  |.  . |.|.     .. ...| . .      .. |  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPEHGVPYHATGLLAFIRRVKASTppdaGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI
|||.|| | .|   |  ..  ..        ...||||| ||||  . .   ...   . | |. . |. . . |   .|.|.| |..   .
awpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1202-1434 3.9e-15 50.2 In-house 51-284 (310) alignment 
Range on Protein: 1202-1434
Range on HMM: 51-284/310.0
RNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCLQYWPEPGR-QQY
..  |||  ||.  | .   |       ..|| |    .    ..||..  ||| |  ||||....  . ||..| .  .      |. |||  |  . |
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeeg.rpkcvgywpslgvtety

GLMEVEFMSGTADEDLV---ARVFRVQNISR-LQEGHLLVRHFQFLRWSAYRDT--PDSKkafLHLLAevDKWQAESGDGRTIVHCLNGGGRSGTFCACA
| . |  .| ...|  .   |  |  .|.    |   |     ....|  . |.  || |    | .   ..  |.   |  .|||  | .| .. .|  
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvp..qrllaqvrhgpcvvhcsagkdrlyvvvalk

TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD
  .. ..  . ||.      |.. .   ..|  || .   
lkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1309-1441 6.4e-15 49.4 In-house 256-386 (392) alignment 
Range on Protein: 1309-1441
Range on HMM: 256-386/392.0
SGTADEDLVARVFRVQNisRLQEGHlLVRHFQFLRWSAY-RDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVD
| ..| |  ..  .. .   |.  |  |  .||  |  .  |     ...|.|.  |     .  .   .|||| | ||.| ||.    .  |   . ||
stssdGdvrskqlkefr..slkash.tvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvd

VFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
.| . | ||  . ..|.| ..| | |||  ||| 
ifqtvkilradrmqfvqteeeyafvydvireylh
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1175-1297 1e-14 48.8 In-house 21-147 (392) alignment 
Range on Protein: 1175-1297
Range on HMM: 21-147/392.0
QLREEFQTLnsvtPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFL-ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSI
 . |||. |    |  |. . ..|  . |  |||  ..|| |.    | .  |   ..|.||.  .|.    |.| .  |  ..  ||||.|..   |.|
lffeefhdl....pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtti

VMLNQLNQ---SNSAWPCLQY----WPEPGR
.|...|..    ..|  . |.    ||. . 
amvtklkegdkgddartvaqfhftewPdkdv
subfamily_egg_pd Subfamily egg 1231-1438 1e-14 48.9 In-house 69-268 (307) alignment 
Range on Protein: 1231-1438
Range on HMM: 69-268/307.0
NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSawpCLQYWPE----PGRQQYGLMEVEFMSGTADEDLVARVFRVQNI
..| |   .       ||..  ||. |  ||||.|.   .  ||||.   .|.    |  |||     . .   | ...| .      | . || ... .
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser...ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklv

SRLQEgHLLVRHFQFlRWSAyrdTPDSKkAFLHLLAEVDKwqAesgDGRTIVHCLNGGGRSGTFCACAT-VLEMIRCHNL-VDVFFAAKTLRNYKPNMVE
   .|  . . |.|   .     . |     |..|  . .  .      ..|.. .|  ...|. |  . .|...|       |  | . ||  ..  ||
Ggdde.erflehwqg.dvnn...ssdvy.splrvlrklrn..l...skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsve

TMDQYHFCYDVALE
.. .| | | . | 
svllylfvyrlvlf
fn3 Fibronectin type III domain 496-577 1.1e-14 47.5 Pfam-A 8-83 (85) alignment 
Range on Protein: 496-577
Range on HMM: 8-83/85.0
FTP-LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDpavnvpgPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQ
...  .. . |.|..|....| || ||. |.. ....       . ....  |..| .....| |||.| |.|.|..|.| |.
vsevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_eak_pd Subfamily eak 924-1070 3.1e-13 43.8 In-house 62-207 (332) alignment 
Range on Protein: 924-1070
Range on HMM: 62-207/332.0
AYDRHRVKLHPMLGDPNaDYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS---DTYGDIKIMLVKTe
 |||. |.| .   ...  ||||  ..  .  ...| |  .. . |. ||.|| ...  .||.. . || .  |  .|.|...     .| ...   .  
pydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.

tLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHaTGLLAFIRRV
 . . ...|  || .     |.|  ...  | |  .|     .||. . .
.vkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrkvm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1202-1441 7.6e-13 42.9 In-house 47-288 (305) alignment 
Range on Protein: 1202-1441
Range on HMM: 47-288/305.0
RNRDKNRSMDVLPPDRCLPFLisTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQsNSAWPCLQYWPEPGRQQYG
....|||  ||   |.    |        .|| |    . | .  || |  ||. |  ||| . ..    .| || .| .   |  ||.|..   ...  
qeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle.kgakkcleyfaskdkdvle

LMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLV----------RHFQFLRWSaYRDTPDSKKAFLHLLAevdkwQAESGDGRTIVHCLNGGGRSGTFC
. | .       |  |.  || .  ....|  |..           |. .  |   |  | .  | | ||.     .| .  | ..|||  | ||.|.  
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwp.drgvpaadlailelle.....karpskgpivvhcsagigrtgsvv

ACATVLEMIRCHNLVD-VFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE
    .|. .   . ..      . .|. . | ..| .|| | ..| |.|..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_CG42327_pd Subfamily CG42327 1174-1365 1.2e-12 42.1 In-house 5-191 (319) alignment 
Range on Protein: 1174-1365
Range on HMM: 5-191/319.0
SQLREEFQTLNSVTPPLDveecsiALLPRNRDKNRSMDVLPPDRCLPFLI-STDGDSNNYINAALTDSYTRSA-AFIVTLHPLQSTTPDFWRLVYDYGCT
... |||. |  .    |      .. .  .||.| ..|.|     . |   .| |...|..|.    |  .   .| .  .|.... ||||.|..    
edvaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsr

SIVMLNQLNQsNSAWPCLQYWPE----PGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRlqEGHLLVRHFQFlRWSAyRDTPDSKKAFLHLLAEVD
 || | .| . .    | .|.|     .... || . | .  . ...  .   . .... .  |    . |. . .|    . | ...|.. .| || 
vivqltdlse.lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk..eesrelthywy.kwle.aevPaeeaaliamllevr
subfamily_CG42327_pd Subfamily CG42327 1076-1140 1.3e-12 42.0 In-house 245-310 (319) alignment 
Range on Protein: 1076-1140
Range on HMM: 245-310/319.0
PDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECE-GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
 . ||.|.||| |.||||  |  |. .   |     ||| . |  .   | . ..| ||| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1195-1442 7.7e-12 39.8 In-house 27-272 (285) alignment 
Range on Protein: 1195-1442
Range on HMM: 27-272/285.0
CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDgdsNNYINAALTDSYTR-SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCLQYWP
|. .    | | ||  ||   .     |   |    .|| |.      .  ...| |  ||  |  |||...|.   . ..||  | .      |  |.|
ctytayeanpdlnryadvrcieetrvvlknhd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv.ekcalyyp

EPGRQ--QYGLMEVEFMSgTADEDLVA---RVFRVQNISRLQEGHLLVRHFQFLRWSaYRDTPDSKKAFLHLLAEVDKWQAEsgDGRTIVHCLNGGGRSG
|   .  ..|  |. .     .| .       . | |        | . | |   |   . .|.  . .. |   | | . .  .    |||  | ||. 
eklgevvkfgkyeitlte.ckeeaiagtilnaltvintedasseplymnhvqvpwwp.dqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrta

TFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG
||         |     ....   . .|  . . |..  |. | | | .||. |
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1070-1143 1.1e-11 39.2 In-house 221-293 (297) alignment 
Range on Protein: 1070-1143
Range on HMM: 221-293/297.0
VKASTPPDAgPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE
..|  | .| ....||||| ||.|  .  ||.|..   . . |.   .. | ..|  ..|| ||. ...||.|.
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 941-1018 2.7e-11 37.4 In-house 90-167 (349) alignment 
Range on Protein: 941-1018
Range on HMM: 90-167/349.0
ADYINANYIDG--YHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSdtYGDIKIMLVK
 |||||||.    .   ...|||| | |  | ||....  .    .. ...  | .  || .|| | |  | .|.. |  
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels..ysnitvklqn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1254-1434 4.1e-11 37.5 In-house 76-253 (290) alignment 
Range on Protein: 1254-1434
Range on HMM: 76-253/290.0
LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSA--W-PCLQYWPEPGR--QQYGLMEVEFMSGTADEDLVARVFRVQNIsrlQEGHLLVRHFQFLRWSaYR
 .||  .|| .. .   ...||| . .. ..   .  | .| ||      ... ..|.  |  ...|.  |   |.     .| .. | | ..  |. ..
rnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd...deeeftvtHsllkgWn.kl

DTPDSKKAFLHLLAEVDKWQAesgdgRTIVHCLNGGGRSGTFCACATVLEMIR-CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD
 .....| .|.|.  | . ..       |||| .|  || .. |      .|   .. | .  . |.||. . ... .  .. |   
nvqedtktllsliqkvkaskt.....pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1197-1288 6.4e-11 36.3 In-house 90-180 (244) alignment 
Range on Protein: 1197-1288
Range on HMM: 90-180/244.0
IALLPRNRDKNRSMDVLPPDRCLpFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPC
 |. | |  |||    || |      .|    .| ||||..     |.| .|.| |||  |. |||... .     .|.|  ... .  || 
dafnpnnswknregaglpfdfnr.vplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 940-1146 8.2e-11 36.1 In-house 68-280 (303) alignment 
Range on Protein: 940-1146
Range on HMM: 68-280/303.0
NADYINANYIDgYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDT--YGDIKIM--L-VKTETLAEYVVRTFALER
.. || |.|..  . |.. | || | .    |||.|. ...   ....    |  ..     .|.. |   . .  |      . |    .|..  ..  
dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn

RGYSARheVRQFHFTAWPEHGVPYH-ATGLLAFIRRVKAST--PPDAGPIVIHCSAGTGRTGCYIVLDV-MLDMAECEGVVDIYNCVKTLCSRRVNMIQT
  | .   .   |. |||   .| . .  ..  | ....      |. | |    .| ||.| . ...   | . . .  .|. .|....   |.  .| 
gdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn

EEQYIFIHDAILEACL
  |. ...  . |  |
lsqfsvvytllaehvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1190-1402 1.5e-10 35.6 In-house 16-178 (255) alignment 
Range on Protein: 1190-1402
Range on HMM: 16-178/255.0
LDVEECSIALLPRNRDKNRSMDVLppdrclpflistdgdsnnyinaaltdsytrsaafivtlhplqsTTPDFWRLVYDYGCTSIVMLNQLNQSNSaWPCL
 |...|.  . |..  |......|                                           |   |.. .   . . .|||  ... .    | 
idedvctehvkPekdkkrknlysl...........................................tvdkfyqtivqtktevvvmlcdfaeegv.ekcs

QYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ-NISRLQEGHlLVRHFQFLRWSAyRDTPDSKKAFLHLLAEVDKwqaeSgdGRTIVHCLNGGGRSG
.|.|    ..  | .|.  .  .  | | |  ..  .... .. |  |.|...  | . . .|.  .  |..|  | .    |     .||| .|.||| 
syfplekdeklkladvnvtttkssadvvlrtleitstlgekkkth.tvkhysykGWie.knaPelareilnilkvvrd....s..ksvvvhCstGiGrsa

TFCACATVLE-MIRC
.|     |   ||| 
afvlaelvyqkmirs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1078-1142 2.3e-10 34.7 In-house 262-341 (350) alignment 
Range on Protein: 1078-1142
Range on HMM: 262-341/350.0
AGPIVIHCSAGTGRTGCYIVLDVMLD------M-A-------ECEGVVD-IYNCVKTLCSRRVNMIQTEEQYIFIHDAIL
. ||..||||| |||| .. || .|       .             . | |   |. | ..|..|.|. .|.|||..|.|
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1377-1440 2.7e-10 34.4 In-house 1-64 (69) alignment 
Range on Protein: 1377-1440
Range on HMM: 1-64/69.0
IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.|||  | ||.||| |    .  |.   |||.|   . .|  .| ||   ..| | .|   | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1377-1440 4.8e-10 33.7 In-house 2-65 (69) alignment 
Range on Protein: 1377-1440
Range on HMM: 2-65/69.0
IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.|||  | ||.||| |    .  |.   |||.|   . .|  .| ||    .| | .|   | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_hpo-7_pd Subfamily hpo-7 1190-1402 1.3e-09 32.4 In-house 19-184 (263) alignment 
Range on Protein: 1190-1402
Range on HMM: 19-184/263.0
LDVEECSIALLPRNRDKNRSMDVLppdrclpflistdgdsnnyinaaltdsytrsaafivtlhpLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsAWPCL
 |...|.  . | .  | .....|                                        |  | . |.. .   . . .|||   |  .    | 
idedvctehfkPekdkkrknlysl........................................lvqtidkfyqtivqtktevvvmLcDfneeg.vekcs

QYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN-ISRlQEGHLLVRHFQFLRWSAYRDTPDSKKAfLHLLaevdKWQAESgdGRTIVHCLNGGGRSG
.|.|    ..  | .|.  .  . .|.. .   . . ... .     |.|...  | . .|  ....  |..|    |   .|   . .||| .|.||| 
syfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpelarei.lnil....kvarns..kslvvhcstGiGrsa

TFCACATVLE-MIRC
 |    .|   ||| 
afsvaElvyqkmirs
fn3 Fibronectin type III domain 292-367 3e-09 30.1 Pfam-A 6-81 (85) alignment 
Range on Protein: 292-367
Range on HMM: 6-81/85.0
PQLLRAGPTYLIIQLNTNSiIGDGPIVRKEIEYRMARGP--WAEVHAVSLQ-TYKLWHLDPDTEYEISVLlTRPGDGgT
...   ..|.| .. .  .  |.|||.. |.|||...|.  | |... . . ...| .| |.||||..|  .. |.| .
lsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq.avngag.e
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1368-1440 4.2e-09 30.2 In-house 213-285 (302) alignment 
Range on Protein: 1368-1440
Range on HMM: 213-285/302.0
QAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
. ...| .|..   || || |.| . |...| .  .. . .   .|..|. .|..|....|| . | ..| |.
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_eak_pd Subfamily eak 1207-1351 1.2e-08 28.7 In-house 56-195 (332) alignment 
Range on Protein: 1207-1351
Range on HMM: 56-195/332.0
NrSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQlNQSNSAWPCLQYWPEPGR--QQYGLME
|  ....| || |  | |.  . . ||||.|..       .|.|  . ..  . ||..|..    .||.| . .  .      .|.|. .|   ..| ..
n.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlle.dvelkleksdkyfpdktreelkfGild

VEFMSGTADEDLVARVFRVqniSRLQEGHLlVRHFQFLRWSAYrDTP
||  .    . |  | . .   |.  | |  | |...  |. . ..|
verkefvkrniletrllel...skGnethr.vlhykvfGwtet.tlp
0038934 (Phosphotyrosine protein) phosphatases II 1342-1433 1.3e-08 30.2 In-house 83-170 (194) alignment 
Range on Protein: 1342-1433
Range on HMM: 83-170/194.0
LRWSAYRD-TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAtvleMIRCHNLvDVFFAAKTLRNYKPNMVETMDQYHFCY
|..    | |. | .  |. |  ||.. .|. .|   |||  | ||.||..|..    .| .... ..  | ...|  .|..... |...  .
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY....Liyrlgm.saeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 925-1055 6.2e-08 26.5 In-house 108-234 (244) alignment 
Range on Protein: 925-1055
Range on HMM: 108-234/244.0
YDRHRVKLHpmLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEvgrvkCSRYWPEDS--DTY-GDIKIMLVKTET
.|  || |    |     |||| ..    |.  .| || |  .   |||.|. . |   .|..  . |        |||.    . |  || . |   . 
fdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdseplewyeeditvtltdrde

LAEYVVRTFALERRGYSARHEVRQFHFTAWPEHG
. .     . .|     .   .  |  . ||  |
fknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_eak_pd Subfamily eak 1066-1145 7.3e-08 26.2 In-house 226-305 (332) alignment 
Range on Protein: 1066-1145
Range on HMM: 226-305/332.0
FIRRVkASTPPDAGPIvIHCSAGTGRTGCYIVLDVMLDMAECE--GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
....    |||   || | .. |. |.| ..|.|... . .     .  . . .    |.|.  . .. |. ||....|.  
tlkky.ihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 918-990 1.1e-07 25.7 In-house 39-110 (332) alignment 
Range on Protein: 918-990
Range on HMM: 39-110/332.0
RQEPMPAYDRHRVKLHPMlgDPNADYINANYIDGYHRSNHFIATQGPKPE-MVYDFWRMVWQEHCSSIVMITKL
|   . ..|. ||.| |   | . |. ||...||| . . .| .| |  .   | ||||| . . | |...  .
riphlycfdhsrvelapq..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 937-988 1.1e-07 25.7 In-house 66-117 (347) alignment 
Range on Protein: 937-988
Range on HMM: 66-117/347.0
GDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMIT
 |.   |||| .|     |...| || | |. | |||.||   . . .| | 
addvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_CG42327_pd Subfamily CG42327 1371-1440 1.1e-07 25.8 In-house 245-315 (319) alignment 
Range on Protein: 1371-1440
Range on HMM: 245-315/319.0
SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCH-NLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
.  |  .||| .| ||.|.  |    .. .    . ||.      .|. . . | |..|| | | |. || 
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1078-1145 1.4e-07 25.2 In-house 265-344 (349) alignment 
Range on Protein: 1078-1145
Range on HMM: 265-344/349.0
AGPIVIHCSAGTGRTGCYIVLDVMLDMAE---CEGV-VD--------IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEAC
  ....||||| |||| .. ||..|.. |    | . ..        |.  | .|   |..|.|   |.|.|..|.|. .
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1229-1299 1.4e-07 25.6 In-house 82-157 (350) alignment 
Range on Protein: 1229-1299
Range on HMM: 82-157/350.0
SNNYINAAL---T-DSYTRSAAF--IVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAwPCLQYWPEPGRQQ
.|.||||     |  |    . |  | |  ||.||  ||.....  . . |..|...   |    | .||.| . ..
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle.kcyrYWqegsydd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1229-1351 9.7e-07 23.1 In-house 12-128 (130) alignment 
Range on Protein: 1229-1351
Range on HMM: 12-128/130.0
SNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNsawpclQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISR
 |.|||| .     |.| .. | |||  |. |||... .     .|.|  ... .      .|||.    ..   ..   .   ||    .   ..  | 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed......eywpdsePlewyeediivtltdrdefknikasnleiesd

LQEGHLLVRHFQFLRWSAYRDTP
|.| |  .  ||   | .   ||
lneshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1178-1439 1.6e-06 22.0 In-house 26-278 (303) alignment 
Range on Protein: 1178-1439
Range on HMM: 26-278/303.0
EEFQTLNSVTPPldveECSIALLPRNRDKNRSMDVLppdrCLPFLISTDGDSnNYINAALTDSYTRSAAfIVTLHPLQSTTPDFWRLVYDYGCTSIVMLN
.||. . |  ||    . |   . .| |||| .||.    ||        ||  || |.  .  ..  | |.|  ||. |. |||... .     ...| 
nefekvvsylpp....svsknqfvknmdknrfvdvi....cldhskvklsds.syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll

QLN-----QSNSAWPCLQYWPEPGRQQygLMEVEFMSGTADEDLVARVFRVQNISrlQEGHLLVRHFQflRWSAYRDTPDSKKAFLHLLAEVDKWQAESG
  .       .| .|  | . .   .   .   ||      .  | .|  | | .      | | |..   |       |.   |.. . ...       
tdseydklggdsvfprnqdflkfeers..irvgefkrvelgdgwvlkvlsvsngd..yksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkys

DGR-TIVHCLNGGGRSGTFCACATV-LEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY
|.. |.   | | ||.|||.   |  | .    . .|.    ...|| .   |. . |. . | .  |.
dstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 931-1055 2e-06 22.1 In-house 11-125 (130) alignment 
Range on Protein: 931-1055
Range on HMM: 11-125/130.0
KlhpmlgdpNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEvgrvkCSRYWPeDSDTYG----DIKIMLVKTETLAEYV
.        . .||||...    |.. .. || |  .   |||.|. . .   .|..  . |        ||| ||. .     || . | . .   .  
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywp.dsePlewyeediivtltdrdefknik

VRTFALERRGYSARHEVRQFHFTAWPEHG
   .  |.    . . .  |. . ||  |
asnleiesdlneshqaltmfqisnwpsdg
subfamily_PTPDC1_pd Subfamily PTPDC1 1046-1139 3.2e-06 21.7 In-house 85-170 (182) alignment 
Range on Protein: 1046-1139
Range on HMM: 85-170/182.0
FHFTAWPEHGVPYHaTGLLAFIRRVKASTppDAGPIVIHCSAGTGRTGCYIVLDVMLDMaEcegvVDIYNCVKTLCSRRVNMIQTEEQYIFIHD
..  .|...||.   . .|  .. |. .   . | . .|| || ||||  |   ..    .    ..  . .|.. |.| . ||| ||  ....
vynfgwkDygvasl.eriLdivkvvafal..qegkvavhChaGlGrtGvliacylvyak.r....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1224-1276 4.2e-06 20.5 In-house 64-116 (347) alignment 
Range on Protein: 1224-1276
Range on HMM: 64-116/347.0
STDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVML
|   |...||||.       |  .|.| .|| .|  |||..|.    | .| .
sraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 914-963 5.4e-06 20.5 In-house 49-95 (95) alignment 
Range on Protein: 914-963
Range on HMM: 49-95/95.0
VKGSRQEPMPAYDRHRVKLHpmlGDPNADYINANYIDGYHRSNHFIATQG
.   |   .  ||  || |       ..||||| ..||| | | .||.||
ipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1376-1440 8.1e-06 19.4 In-house 268-344 (349) alignment 
Range on Protein: 1376-1440
Range on HMM: 268-344/349.0
TIVHCLNGGGRSGTFCACATVLEMIRC----------HNL-VD-VFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
 .|||  | ||.|...    .|...            ..|  | ....  .|| .. .||. . |. ..|.  |.|.
llvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf