Gene INPP5F in Homo sapiens

Synonym: MSTPO47, SAC2, hSAC2, MSTP007, INPP5F

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP108_AA protein Get Run
HsapP108_AA_233-566 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 48-586 4.4e-200 658.2 In-house 3-523 (951) alignment 
Range on Protein: 48-586
Range on HMM: 3-523/951.0
VEGVIGKIQLHSDLPWWLILIRQKALVGKLPG-----DHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLL--KTFTHIKSN
| ||||||.|.|.  ..|.........|.||      ..||......|.|.|||.....||.| |......|.. .||| . ...|     |....|...
vygvigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskvnnkkwdlidid

VSA-PNKKKVKESKEKEKLERRLLEELLKMFMDsESFYYSLTYDLTNSVQRQSTGERDGR-PLWqkvDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGF
.|. ...|. ||..|.||||.|||||| |...| .||||||..||||..|.... |.. . . |   |.||||||....||... . . . ...|.||||
ssgylqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddw...derFfWNkfllkdlinyrdkldkefltpviqGf

VQIEELVVNytessddeksspetppqestcvddiHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVG
|...|....                         . .. ..|||||||.|||.|.||||.|..|||||.||||....|....|||.| ||||||||.|.|
vetkeisie.........................klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsg

YRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKW
..|.|.....|||.|| ..|. ||.|||. |.|.||.||..|...||....|| .|.| ..........|||||...|.|||||..|...| . |.....
kkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgy

CWVDEAG-VICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLP-VKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAG
...|. . ||..|.|.||.||.||||||||||.||...|.|.||.|||.. ||....  .... .. .||.||| ||||||||.|||||.||.|||||||
fsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaG

VMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEA
|.|||..|..|||||.|||.|||.||||..|   ...   .  ..||.. 
vlkdgyksvsryylnnfkdkyrqkvidlllGklpkqevvelidpkkeeke
subfamily_SAC1_pd Subfamily SAC1 276-567 3.2e-112 366.5 In-house 157-451 (458) alignment 
Range on Protein: 276-567
Range on HMM: 157-451/458.0
FLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGY-RYNPRPRLDrSEKETVAYFCAHFEEQLNIYKKQVI
.  .|||||| .||| || .|||||.|||||.|||||........ ||||.|||.|..||| .  .| |...|  ..... . | .|..|| ..|...|.
ikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqielygenvl

INLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVD-EAGVICKQEGIFRVNCMDCLDRTNVVQAAIA
.||||| |.|| .|.|| . |   |.... ||.||||..|| |... ...|.| . .   .. . ... |  .. .|.|..| ||.||||||||||. .|
vnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqslla

RVVMEQQLKKLGVMPPEQPLPV--KCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQG
| |...||..|||.  |. |    . ..... .||.|.| .| |||||.||| |||||| |.| |...|||||. ||| | |.| .||  |||. |
revLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflg
Sac_COG5329 278-570 1.5e-103 338.7 In-house 227-520 (1070) alignment 
Range on Protein: 278-570
Range on HMM: 227-520/1070.0
VALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQ-VGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIIN
 .|||||| .||| |. .||||..|||||.||||| .   ... ||.|.|||.|.||.| ..  ..|. .  || ..| . |  ||... . | ...|.|
LtlISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivN

LVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCW--VDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIAR
|... ..|. .  .| |.. | .. ......|||| ... ..|..|. | . |.. .|....    | |  .| .|.|.||.||.||||||||.|  |..
LlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqlisk

VVMEQQLKKLGVMPPEQPLpvKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPV
 |. .|.....|.   .        ... .||.|||.||..| || |||..|||.| | .|| ..| ..|. |.|.|.| |. .|  |||. |   
rvlleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklp
Syja_N SacI homology domain 49-421 2.6e-96 313.5 Pfam-A 2-319 (319) alignment 
Range on Protein: 49-421
Range on HMM: 2-319/319.0
EGVIGKIQLHSdlPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELElckkhhfginkpekiipspddskfllktfThiksnvsapnkkk
 |..| |.|.|     |..| ..  |.|. |.|...|........|.. | .. . |                             .             
ygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie.............................e.............

vkeSKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERD-------GRPLWQKVDDRFFWNKYMIQDLTEIGtPDVDFWIIPMIQGFVQI
   .||.|. | . | .||| .. |.|||.| .||||.|.||.|. |..         ||...||.||.||......|.|.. .|.. |..|.|||||..
...ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk.ldlsrwllpliqGfveq

EELVVNytessddeksspetppqestcvddIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIH-V-H--NHTLSFVQTRGSVPVFWSQ-
... |.                         . .. ..||||||..|||.||.|||.|..|||||.|||||...   .  ....||||.|||||.||.| 
rsievk........................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqa

VGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLF-----NNSHLTYVSFDFHEHCRGMKFEN
 .. ..|.....||...... |. ||..... |.|.|..||... |||| ...|| ...  .     ....| |..||||..|.|.||||
snlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
Syja_N SacI homology domain 49-421 2.6e-96 313.5 In-house 2-319 (319) alignment 
Range on Protein: 49-421
Range on HMM: 2-319/319.0
EGVIGKIQLHSdlPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELElckkhhfginkpekiipspddskfllktfThiksnvsapnkkk
 |..| |.|.|     |..| ..  |.|. |.|...|........|.. | .. . |                             .             
ygilGlirlls..esyllvitkrekvakirgehpiykiksvefiplnseeeessaie.............................e.............

vkeSKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERD-------GRPLWQKVDDRFFWNKYMIQDLTEIGtPDVDFWIIPMIQGFVQI
   .||.|. | . | .||| .. |.|||.| .||||.|.||.|. |..         ||...||.||.||......|.|.. .|.. |..|.|||||..
...ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielk.ldlsrwllpliqGfveq

EELVVNytessddeksspetppqestcvddIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIH-V-H--NHTLSFVQTRGSVPVFWSQ-
... |.                         . .. ..||||||..|||.||.|||.|..|||||.|||||...   .  ....||||.|||||.||.| 
rsievk........................skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqa

VGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLF-----NNSHLTYVSFDFHEHCRGMKFEN
 .. ..|.....||...... |. ||..... |.|.|..||... |||| ...|| ...  .     ....| |..||||..|.|.||||
snlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
subfamily_Synaptojanin_pd Subfamily Synaptojanin 278-568 3.5e-74 241.6 In-house 149-435 (754) alignment 
Range on Protein: 278-568
Range on HMM: 149-435/754.0
VALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRY-NPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIIN
.||||| |  |||.|.. |||...|||||.|||||.| . .. .||||.|||||.||.| | .  . . .| |. . . | |  |.|.. . | ..||.|
aalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivn

LVDQAGREKIIGDAYLKQVLLF-NNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDI-ILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIAR
|. . . |... .|. |.      .... .|.||.|....| | |....| . .    . ....    .  |  .|.|. ||||.||||||| ||.... 
llGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgkevekeqtGvlrvnClDCldrtnavqtvlgl

VVMEQQLKKLGvMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTrtgerklAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQ-GI
 |.|.||. |. .   . .  . ..... .| .|||.||. |||| ||.|.         .. .|||  | .|   | | |. .|. |||.  | 
evlekqlealk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgarsvartiqnnfldsskqeaidllllgn
subfamily_FIG4_pd Subfamily FIG4 276-584 3e-55 178.6 In-house 229-557 (569) alignment 
Range on Protein: 276-584
Range on HMM: 229-557/569.0
FLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIH-------VHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYF-CAHFEEQLN
  |.||.|||.. || |. .|||...|.|||.|||||..|        ...  ||||.|||||..|||   .  ..|..   . .  |     ||.. ..
iyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfq

IYKKQV-IINLVDQ---AGREKIIGDAYLKQVL-----LFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWcWVDEAGVIC--KQEGIFRV
 |   . |.||| .     ||.|.  .. . .      | ....|.|.|.|..   .  . . ...| .   ...    . ..... . .   |||| |.
ryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGi.flsapdlestkiqeGivrt

NCMDCLDRTNVVQAAIARVVMEQQLKKLGVMP-PEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKD
||.|||||||. | .|..| .  |||.||..  ..  .  ...|. . .. . || .. ||.|.   .   | .  ....   .| ... .||| | |.|
nCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvd

AYRQAVIDLMQGIPV-TEDLYSIFTKEKEH
| .|  |.|. |. . .| | |..  | ..
adkqdainlflGvyspreglpslWeletdf
hSac2 Inositol phosphatase 589-699 2.4e-35 109.6 Pfam-A 3-114 (115) alignment 
Range on Protein: 589-699
Range on HMM: 3-114/115.0
KENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLidATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIG--PEPTLF-G
|.......||..|. ....||.|||||...|||.|...|.|   .|... ...|||...|.||..||.| .||.|..|..||...|||||  .|.||.  
kdpeiereelreqaiekckklvlpddeeliggWlLvsidhsn..ktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysestlsed

KPKFSCMRLHYRYK
| .....|..||..
ksenlglrinyrks
subfamily_SAC1_pd Subfamily SAC1 144-249 3.8e-25 79.4 In-house 49-155 (458) alignment 
Range on Protein: 144-249
Range on HMM: 49-155/458.0
PNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQST---GERDGRPLWQKVDDRFFWNKYMIQDLTEigTPDVDFWIIPMIQGFVQ
| ||. ..  |..| | .   .||.  ..||.||.| |||||||.||..     .   |.|....|.||||||....||..  .|... .|.|.|.||..
pvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrk..epelesfilPvikGfik

IEELVVNYT
|.||..| .
ikelslnak
Sac_COG5329 50-245 2.6e-15 46.6 In-house 63-219 (1070) alignment 
Range on Protein: 50-245
Range on HMM: 63-219/1070.0
GVIGKIQLHSDLpwWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELckkhhfginkpekiipspddskfllktfthiksnvsapnkkkv
||.| |.|  .|  .||.|..|  |..  . ... |. .. ..|| . . .|.| |                                            
gvlGlielegsl..flivitgkskvaqvipgetiykilavdfislnnnkwddeeies...........................................

kE---------SkekeklerRLLEELLKmFMDSESFYYSLTYDLTNSVQRQstGERDGRPLWQKVDDRFFWNKYMIQDLTEI-GTPDV------DF--WI
 .         .          . || |      |||.|...|.||..|..  ..    . ... |..|.||......| .  .  ..      |   ..
.deasteklrse........hpcselkk.LlsngsFYfStdfditntLqkr..lkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFl

IPMIQGFVQIEELV
 ..|.||..     
ttvIrGFaetvfik
subfamily_FIG4_pd Subfamily FIG4 153-246 5.3e-09 26.0 In-house 120-224 (569) alignment 
Range on Protein: 153-246
Range on HMM: 120-224/569.0
KEKEKLERRLLeELLKMFMDSESFYYSLTYDLTNSVQRQST---GERDG-----R------PLWQKVDDRFFWNKYMIQDLTEIGTPdvDFWIIPMIQGF
.||   | |.| .|.|    .. ||.| .||||...|  ..    .|.      |          . ...| ||..... |... ..    |.. .| ||
sekssdearyl.klfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvkt..fdWlleiihGf

VQIEELVV
|. ... |
vsqskisv
subfamily_Synaptojanin_pd Subfamily Synaptojanin 158-244 1.3e-07 21.4 In-house 59-140 (754) alignment 
Range on Protein: 158-244
Range on HMM: 59-140/754.0
LERRLLEelLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQkvDDRFFWNKYMIQDLTEIGTpDVDFWIIPMIQGFVQIEEL
 | |. |  || .. |..||.| . | ..... ... .|  .   .  |.|||||. .   |.  |  . | |..... | |.|  .
dedriie..lkkllasgtfyfsssadsasrldlslsaqrrkqeese..dnrffWnrslhlhlqrfgv.ncddWllkvmcGsveirtv