Gene SYNJ1 in Homo sapiens

Synonym: INPP5G, PARK20, SYNJ1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily Synaptojanin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP110_AA protein Get Run
HsapP110_AA_220-519 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Synaptojanin_pd Subfamily Synaptojanin 94-853 0.0 1345.4 In-house 2-753 (754) alignment 
Range on Protein: 94-853
Range on HMM: 2-753/754.0
KVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGI-SLDLSLNAHRSMQEQT
|..|||||||||||| ||..|..|||||||.|||||...|.|..||||..||| ..||||||.|..|.|.||.|||..||..  .|||||.|.|..||..
kivdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasdedriielkkllasgtfyfsssadsasrldlslsaqrrkqees

TDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSV
.|||||||.||||||...|||||||||..|||.|||||.||..|||||.||||||||||||||||||.||.|.||||||||||..|||.|.||.||||||
ednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsv

PLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKP
||||||||||||||.|..||||||.|.|||||...||. ||...|||||||||||..|||||..||||||||.|...|.|||||.|||||.|||...||.
PlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkk

QVQK-FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKA--
|... . ...||. .|.||...|.|..|.||||||||||.||..||||.|.||||||.|..|...|.||.|||.|.||.|||.|||||||||||||||  
qlklflesasfflskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealklsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkakv

-KLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRvseqtlqsASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFR
 |||||||||.|||||||.|||||||||.||||||....|||||||||.. .||        ||.|.||...|. ......||.|.||||||||||||.|
sklkdgarsvartiqnnfldsskqeaidllllgntyveeladkarallkssllr........asakilkelvereqelteakklricvgtwnvnggkqlr

SIAFKNQTLTDWLLDAPKLAGIQefqdkRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPF
|.|.||..|||||||.|.|.|..     .|||.||.||||||.|.|||.|.|||||||.| ||.||||..|||.|||||.||||||||||||.||...||
svalknesltdwlldlpelsgae.....dskpadiyaiGfeelvdlnasnlvsasttnrkewaeelqkvlsrdakyvlltseqlvGvclfvfvrpklvpf

IRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQ
||||||.|||||.|||.|||||||||.|.|.|||||.|||.|||||.|||||||..|||||..|||||.|.|||||||.|||||||||...|||||....
irdvavstvktGlgGaaGnkGavairlllhstslCfiCshlaagqskvkernedyaeiarkiafpmgrtleshdyvfWlGdfnyridlekdevkelvkkk

NWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRK
..|.|.. ||| .||..|.||.|| ||..||||||||||||||||||||.|.|||||||||||.|
dydklvendqltkqkkkgkvfkgfaegeltfaPtykydlfsddydtseklrvPaWtdrvlwrrkk
subfamily_INPP5F_pd Subfamily INPP5F 151-852 1.8e-190 626.3 In-house 122-804 (951) alignment 
Range on Protein: 151-852
Range on HMM: 122-804/951.0
DEDRISEVRKVLNSGNFYFAWsasgiSLDL------SLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDD-WLLRLMCGGVEIRTIYAAHKQAKACLI
..  . |..| |..|.||.       . ||        . ..| . .. |.|||||. |   |  |  . |. .|. .. | ||...|.  .....  ||
ekrlleelkkllsdgsFYysl.....dfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltli

SRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGsHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGS
|| | .||||||. || .|||.||||||||....  . | ||.|||||||.||||.| ..   .... | .|.. ||||.||  . . |||. |||||  
srrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkyk.pkikitrseeetqpaFdehfkeqlkkygkvvivnllsq

KEGEHMLSKAFQSHLKASEhAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSE-VQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLA
|. |  ||||.. .|...|  .|. ...||.|.  .| | |.......   .. .. |.|  . .| |   |.| .|||||||||||| ||. .....| 
kssekklskaykeqllkle.skdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavle

KQLEALGLAEKPQLVT--RFQEVFRSMWSVNGDSISKIYAGTGALEGKA----------KLKDGARSVTRTIQNNFFDSSKQEAIDVlLLGNTLNSDLAD
 ||| ||| |  . ..  .... .  .|. ||| ||..|||| || |.            ||||  ||.|  .||| |. .|..||. |||.. . . ..
lqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidl.llGklpkqevve

KARALLTTGSLRVseqtlqsasskvlksmCENFYKYSKPKKIRVCVGTWNVNGGKQFrsiafknQTLTDWLLDApklAgiqefqDKrSKpTDIFAIGFEE
   .    .. ..                 |. .|. . . | . ||. ||||  ..       . |  .| .    .      .|  | .|.. .| .|
lidpkkeekeeel................rekeekftetsninllvgsvnvngsskk.......adlskllfpi...g......ek.fk.pDlvvlGLqE

MVELNAGNIVSASTTNQKLWAVELQKT---ISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCS
.||| ||.|..| .. .| |   ....   .||..||..| ||||... | .|.| ..|  ...| .||.|||.|| .|||||||.|. .  || ||| |
vvELtaGsiLaaDyskskfWEklvedlLnkvsreekYlkLrseqlsslLlllfvredkakkvkevegdtkktGfgGlagnkGavavrfeysatsFcfvns

HFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDL
|.|||.| | || .|. ||||...|. ....  ||..|| ||.|||||||||||.  ...|..|.|.  ||| .. .||.|| || |  . | |||||||
HlaAGasnveeRrsDykeiarsitFsrskrikdhDsifWlGDlnyRidlpneevRRelldqeidkLleyDqLtkeieaGevFegfkEetlkFrPtYkyDl

FSDDYDTSEKCRTPAWTDRVLWRRR
 ...|||||| ||||||||.... .
gtknYDtsekeRtPaWtDRiiykge
Sac_COG5329 91-847 2.9e-125 410.7 In-house 51-813 (1070) alignment 
Range on Protein: 91-847
Range on HMM: 51-813/1070.0
TYSK---VLDAYGLLGVLrlnlGDTMLHYLVLVTGCMSV-GKIQESEVFRVTSTEFISLRIDSSDEDRIS----------------EVRKVLNSGNFYFA
 ...   .   ||.||..      . . .| ..||  .| . |.. .....   .||||. .. |. .|.                | .|.|  | ||| 
gfrslssaheiygvlGli....elegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfS

WSASgISLDLSLN--AHRSMQEQTTDNRFFWNQSLHLH----LKHYGVNCD------DWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVR
   . |.  |  .     ... .| |..|.||. |        ..  ..        ..|  . .| .|   |.   |..   ||||.| .||||||. |
tdfd.itntLqkrlkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflar

GTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHL
| .|||.|||||||||.||  . . ||.|.|||.|.|||| . .  . ... .| .||  .|||.||  | . ||.. |||||. |. | .||.....||
GvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhl

KASEHaADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFY--FNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL
|.||   .|. . ||.|.  .  . ....  |.  .|. |. |.|    . ...   |.| .|||||||||||| .|  .....| .|.. ..  .. . 
klsek.pkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidd

VtRFQEVFRSMWSVNGDSISKIYAGTGALEGKA----------KLKDGARSVTRTIQNNFFDSSKQEAIDVLLlGNtlnsdLADKARALLttgslRVSEQ
   | . .. .|. |||.||.|| ||||| ...          .|.|   ||.| ..|||.| .||.|||.|| |      | |.    |     . . .
e.dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllL.gk.....lpdqeavel.....ydpin

TLQSASSKVLKSmcenfyKYSKPKKIRVCVGTWNVNGgkqfrsiAFKNQTLTDWLLDAPKLAGIQEFQDKRskptdifAIGFEEMVELNAGNIVSASTTN
.     .. ..|      .... | . . ..| |.||        .... |...||.  . . .. ... .       .. ...  || . .....| . 
eyvnlrlrkses......eftaaknvsiftltfnsng.......essstkllklllkvlekkisklvvgvv.......glqkqiwlelillssltksefk

QKLWAVELQKTIS-RDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIE
.. . . ..|  .  ..|...  |.|| .. ...... . .     . . . ||| ||  .|||||.|...   .. .|| ...|... ...||| . . 
eeeeenlvrkyenklkkkkleqsssqltalfilfkksadikevvssekaagrktgtgglnankgavkieaeseglvfifvdasaaledenesernskyes

IARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQnWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTD
| ...|.... |   |.  .. ...|..||...|||..   ..  | ... ..  .. . . .. ..||.   . ...|..   | ....|. ... .|.
itkrvskeipkmikdhqlilldiainltidydeeevraekeke.idrelkkydtkqeltekvfvekvleptevpellekksyeddndtdtedayrklrtr

RV
. 
kl
subfamily_SAC1_pd Subfamily SAC1 95-523 1.2e-96 315.2 In-house 4-453 (458) alignment 
Range on Protein: 95-523
Range on HMM: 4-453/458.0
VLDAYGLLGVLRLNLGdtmlHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSS---------DEDRISEVRKVLNSGNFYFAWSAsGISLDLSLNAH
| . .|.||...| .|    .||...|   .||.|. . ..||. .| |..   |          ..  .. ...||.| .|||.     ..  |. . .
vvkiagilGiikLlsg....kylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsyty.dltnslqrlek

RSM-------QEQTTDNRFFWNQSLHLHLKHyGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYL
 .          ...|.|||||. |  .|..   . ....| .. | ..|...   .|. |  |||| |. |||||..||| . .|.|||||||||.| .
vtsaalkerslleradeRffwnkhlledlrk.epelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqivea

DDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSrGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQShLKASEHAADIQMVNFDYHQMV
. ...||.|.|||.||.|.| .      .|..|   | .  ||..|. ....|||....|||.  |  |. | .|..| .  .... .|. | ||.|.  
ekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayes.vvralnkkkikyvafDFHkeC

KGGKAEKLHSVLKPQVQKFLDYGFFYF-NGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQ---LVTRFQEVFRSMWSVNGDS
.  . ..|. ...   ..  ..|.|.  . ..... |.| |||||.||||||| ||. |. |.| |||| ||. .. .     ......|. .|. |.| 
rkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnada

ISKIYAGTGALE------GK----AKLKDGARSVTRTIQNNFFDSSKQEAIDvLLLGNT
.|. |||||||       ||      |.||  ||.| ..||| |  .|..|| |.||..
vsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsid.Lflgky
Syja_N SacI homology domain 98-384 8.4e-86 279.0 Pfam-A 1-318 (319) alignment 
Range on Protein: 98-384
Range on HMM: 1-318/319.0
AYGLLGVLRLNLgdtmLHYLVLVTGCMSVGKIQ-ESEVFRVTSTEFISLRIDSSD---------------EDRISEVRKVLNSGNFYFAwSasgiSLDLS
|||.||..||.      .||...|.. .|.||. | ......|.|||.|. ....               |. .....|.|.||.|||.      . ||.
aygilGlirlls....esyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfS.y....dyDlt

LNAHRSMQE----Q-----------TTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAA-HKQAKACLISRLSCERAGTRFNVRGTNDDGH
 ...|....    .            .|.||.||. |. .|.........||| |..| ||.|.|.   .|... .|||| |..|||||.. ||..|||.
rslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGn

VANFVETEQVVY-L-D--DSVSSFIQIRGSVPLFWEQ-PGLQvGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKA
|||||||||.|.   .  ..| ||.|||||||||||| ..|.  .......|  ||. .||..||..|.. |||...||||..|..|..||.|.......
vANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnls.lkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelink

S----EHAADIQMVNFDYHQMVKGGKAE
     ..  ......||.|. .|| | |
lnkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 98-384 8.4e-86 279.0 In-house 1-318 (319) alignment 
Range on Protein: 98-384
Range on HMM: 1-318/319.0
AYGLLGVLRLNLgdtmLHYLVLVTGCMSVGKIQ-ESEVFRVTSTEFISLRIDSSD---------------EDRISEVRKVLNSGNFYFAwSasgiSLDLS
|||.||..||.      .||...|.. .|.||. | ......|.|||.|. ....               |. .....|.|.||.|||.      . ||.
aygilGlirlls....esyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfS.y....dyDlt

LNAHRSMQE----Q-----------TTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAA-HKQAKACLISRLSCERAGTRFNVRGTNDDGH
 ...|....    .            .|.||.||. |. .|.........||| |..| ||.|.|.   .|... .|||| |..|||||.. ||..|||.
rslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGn

VANFVETEQVVY-L-D--DSVSSFIQIRGSVPLFWEQ-PGLQvGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKA
|||||||||.|.   .  ..| ||.|||||||||||| ..|.  .......|  ||. .||..||..|.. |||...||||..|..|..||.|.......
vANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnls.lkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelink

S----EHAADIQMVNFDYHQMVKGGKAE
     ..  ......||.|. .|| | |
lnkklkekkklkyiefDfhkeckgkkfe
subfamily_FIG4_pd Subfamily FIG4 71-519 5.5e-63 204.2 In-house 43-538 (569) alignment 
Range on Protein: 71-519
Range on HMM: 43-538/569.0
MFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGdtmlHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRID------SSDEDRISEVRKVL-N
.|..  .  | .. .|| .  ..|.. |||.||..|.  |    .||.|||   .|..| .  ....  ...|..  |      ||||.|  .. | .  
eftkneikellasleeanrdglekkvsayGilGfvrfleg....yylilvtkrkkvaviGghaiykiedialikitedskksekssdearylklfkdvdl

SGNFYFAWSAsGISLDLSLNAH-------RS-----------MQEQTTDNRFFWNQSLHLHLKHYgVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISR
. ||||..|   ..  |  |         ..           ... .....| ||. |   ||.  |.  |||| .. | |.  .|    |. . .||.|
tknfyfsysy.dltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdt.vktfdWlleiihGfvsqskisvlgksiyvtliar

LSCERAGTRFNVRGTNDDGHVANFVETEQVV-------YLDDSVSSFIQIRGSVPLFWEQPGLQVGSH-RVRMSRgFEANAPAFDRHFRTLKNLYGKQI-
 | . ||.||  || | .|.||| |||||.|       . .|..|||.|.||||||.|.|   .. .  .... .  .  | |  .||. | . ||  | 
rsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidv.vdPfasaaalhfddlfqryGspii

IVNLLGSKE---GEHMLSKAFQSHLKASE----HAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFY-FNGSEVQRCQSGTVRTNCLDCLDR
|.||. .||    | .|...|.. ..       .   .. ...| ... |  ... |. . |  ..     |.|.  . .| .. |.| |||||.|||||
ilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldr

TNSVQAFLGLEMLAKQLEALGLAEKPQLV--TRFQEVFRSMWSVNGDSISKIYAGTGA---LEGKAK-------LKDGARSVTRTIQNNFFDSSKQEAID
||. |  .|   |. ||..||. ....|   .   ...  ..   || ..  |.|.     ..   |        .|  ....| . | | |  ||.||.
tnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdain

VLL
..|
lfl
DUF1866 Domain of unknown function (DUF1866) 906-1045 7.6e-62 196.3 Pfam-A 1-142 (146) alignment 
Range on Protein: 906-1045
Range on HMM: 1-142/146.0
DIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTIT
|..|.||..|.|....|||||.|||||.|..||.|| ...|...||.|||.||||..||.|||||.|||||||.|||..|.|||.||||.|...|.|...
dveilevdpearravfkeviaaqGPpDativvslksgdedekeifdealieeLlqelaslGeviLvRfvedkmlvtFrdgesALevlslkgikvlgralk

IALKSPDWIKNLEEEM---SLEKISIALpsSTSSTLLGEDAEVA
|.|||.||.|.||||.   . |.||..|  ...||||.|||..|
irlKskdWlksleeEivlsttetisvsl..tanstlleedasla
Exo_endo_phos Endonuclease/Exonuclease/phosphatase family 577-898 2.6e-32 102.6 Pfam-A 1-249 (249) alignment 
Range on Protein: 577-898
Range on HMM: 1-249/249.0
GTWNVNGgKQF---RsiAFKNQTLTDWLLDA-PKLAGIQEFQDKrskptdifaigfeemvelnagnivSASTTNQKLWAVELQ--------------Kti
.||||.| ..    |  | |.. | |.| .  | .  .||...                           | .... .| ||                  
ltwNvlg.wnarsdr..akkldqladllqsedpDvllLQEvded........................plsellatglaselgldgdgksggggggda..

srdnkyvllaseqlVGVCLFVFIRPQHAPFIRDVAVDTVKTGMG---GATGNKGAVAIRMLfhTTSLCFVCSHFAAGQSQVK--ERnEDFIEIARKLSFP
              .| .| .. .  ..  ||.. ....|.| .   . .||||.|..|.    ..|..|..|...|... .  || ... ||..   ..
..............gggglallskypldkkirrtfqldgkagiavprlssgnkgdvpvrfr..gktlalvntHltpgnrlrqrder.allaeidkladds

MGRmlfshdYVFWCGDFNYRIDLPNeevkelirqqnwdsliagdqlinqknagqvfRGFLEGKVTFAPTYKYDLFSDDY-------------DTSEKCRT
 |.      .|...||||.|.|.|.                               .|| |.. .|.|....| .....             ||.||.|.
rgs......pvilaGDfNsrpdspd...............................kgfresaadflpgdgfddglrallphlllptspgttdtyekare

PAWTDRVLWRRRKWPFDRSAEDLDLLNASfqdeskilytwtpgtllhygraelktSDH
||..|..|.... . ...|...|   . .                          |||
parlDyilvssgwpalvvsgasllsdrgg..........................SDH