Gene SCP1 in Homo sapiens

Synonym: NIF3, NLI-IF, NLIIF, SCP1, CTDSP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family FCP
Subfamily SCP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP121_AA protein Get Run
HsapP121_AA_89-232 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_SCP_pd Subfamily SCP 92-232 3.3e-87 281.5 In-house 2-142 (142) alignment 
Range on Protein: 92-232
Range on HMM: 2-142/142.0
CVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKD
|.||||||||||||||||.||||..||||||.||||||||||||||||.|.|||||.||||||||||||||||||||....||||||||||||.||||||
clvidldetlvhssfkpvknadfvvpveidgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkkkvlrarlfrescvfhkgnyvkd

LSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDT
||||||||..|.|.|||||||.|||.|||||.||||...||
lsrlgrdlkkviivdnspasyifhpenavpveswfddkedt
NIF NLI interacting factor-like phosphatase 92-250 9e-53 170.4 Pfam-A 2-158 (159) alignment 
Range on Protein: 92-250
Range on HMM: 2-158/159.0
CVVIDLDETLVHSSFKPVNNADFIIPveiDgVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDK-WGAFRARLFRESCVFHRGNYVK
..|.|||||||||..|. .. |. ..   .   ....| |||..||||... . .| |.||||  .||.|| | ||.    |..||.||||....|.|||
tLVLDLDetLvhskekkdlkedgkkv...e.ektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklfkkrlyresctlrngkyvK

DLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDN-MSDTELHDLLPFFEQLSRVDDV
||| |||||.||.|.|.|| |. ..|||..|. .....  .||||..||||.|.|...|||
dLsllgrdlsrvvivDdsprsfelqpdngipiepfygdsdkdtellkllpflealeksddv
subfamily_CTDSPL2_pd Subfamily CTDSPL2 92-231 9.9e-49 157.0 In-house 1-141 (142) alignment 
Range on Protein: 92-231
Range on HMM: 1-141/142.0
CVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGA-FRARLFRESCVFHRGNYVK
..|.||||||||.| .....| .  ||. . ...|||| .||.. |||.|. .||| .|||||   ||| . ||||     .. |||||.||.  |||.|
slvldldetlvhcslekleeatltfpvlfenktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhrlfrehcvcvdgnyik

DLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSD
||| |||||....|.|||| .. .  .| .|. |||..  |
dlsilGrdlektiivdnspqafayqlenGipieswfedend
CPDc_SM00577 90-232 6.7e-48 154.4 In-house 2-146 (146) alignment 
Range on Protein: 90-232
Range on HMM: 2-146/146.0
KICVVIDLDETLVHS-------SFKPVNNADFIIPveidgvvHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRAR-LFRESC
| ..|.|||||||||       ||..|.. |....       ..|.|||||.|||||... .|||.|.||.. .||||...||||  . .  | |.|..|
kkvLVlDLdetLvhsanmaepksfsevsptdslae.......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkrllkyrvlyRqdc

VFHRGNYVKD-LSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDT
....|...|| || | .||..|.|.|||..|. ..|.||... ......|||
rlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisalsdt
subfamily_DULLARD_pd Subfamily DULLARD 93-232 2.3e-45 146.0 In-house 4-152 (153) alignment 
Range on Protein: 93-232
Range on HMM: 4-152/153.0
VVIDLDETLVHS--------SFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKW-GAFRARLFRESCVF
.|.||||||.||        . ||. . ||.. | ||..  ..|| ||||||.||... . .. |.||||. .||..|.| ||.  | .. |..|..|| 
lvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryyrqhCvl

HRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDT
. |.|.|||| .  || .|.|||||| .| ..||||.|. ||. . |||
esgkytkdlslvssdlssviilDnspvayrknpdnaipikswlsdpsdt
subfamily_TIM50_pd Subfamily TIM50 129-231 8.6e-28 89.0 In-house 23-125 (126) alignment 
Range on Protein: 129-231
Range on HMM: 23-125/126.0
VLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDN
. ||| || ||....|||| |.||.. . .| |. | ||  .  . ||||... .  |. ||||| | |||..|...|  ..|. ..|.||. .. |  |
fkkrPgvdafleqlaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkksvklqpenalalkkweGn

MSD
. |
add
subfamily_FCP1_pd Subfamily FCP1 90-215 7e-15 47.4 In-house 1-133 (146) alignment 
Range on Protein: 90-215
Range on HMM: 1-133/146.0
KICVVIDLDETLVHSSFKPV-----NNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGA-FRARLFRESCVF
|...|.|||.||.|.. .|      ..   |   ..    .  || .||.. |||... .|.|  ..| .  .||. .| .||. .  |  |..    ..
klvLvvDlDqtlihttkdptievkeekkkdikkftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdell

HRGNYVKDLSRL-GRDLRRVLILDNSPASYVFH
.  . .|.|..|  .|   |.|.|.  . . |.
dassktkklkklfptddsmvviiDDredvWnfa