Gene LHPP in Homo sapiens

Synonym: HDHD2B, RP11-12J10.1, LHPP

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP128_AA protein Get Run
HsapP128_AA_12-240 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LHPP_pd Subfamily LHPP 14-241 2e-100 326.4 In-house 1-224 (227) alignment 
Range on Protein: 14-241
Range on HMM: 1-224/227.0
VLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKEQGLRPYLLIHDGVRSEFDQI
||||.||||.     ...||.|.|||..||.....||||.||....|...|| .|.|||||..|.|......||.|.|.|. ||||||..|.|...|..|
vllDlsGvlhn....edaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedi

DTSNPNCVVIADAGESFSYQNMNNAFQVLMELEKPVLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIG
||..||.|||..| |||.|...|.||..|.|..|..||...||.|||...||.|..|...||||||.|.|||||||||..||..||...||....|||||
dtdkpnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiG

DDIVGDVGGAQRCGMRALQVRTGKFRRD
||.  ||.||...|.|...|.|||||..
DdvedDveGAlkaGlrgvlVktGkfrpe
Chronophin_1 13-240 1.9e-36 116.9 In-house 3-233 (261) alignment 
Range on Protein: 13-240
Range on HMM: 3-233/261.0
GVLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFD-ISEQEVTAPAPAACQILKEQ--GLRPYLLIHDGVRSE
 ||||. |||.     |..|..|  |....||.   .| | ||.|.. |.||. .|.|||.| ....|... | || ..|..|  . . |.|  .|.|.|
lvLlDldGVlik....geeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrke

FDQID---TSNPN---CVVIADAGESFSYQNMNNAFQVLMELekPVLISLGKGRYYKETSGLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIG
...     ...|.    .|.    |..|......| ... .     ..   . ..   ..| .   |  . |.| | | .. |||||.|  |..||. ||
lreaGlrlvdepedrveaVvvGydeelsfeklaeaialirdg..alfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekig

VEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRR
......||.|| .  |.  ..|.|...| |.||  ..
adpeetvmvGDRldTDilagaraglstllvltGvsel
Hydrolase_6 Haloacid dehalogenase-like hydrolase 14-112 1.6e-19 61.2 Pfam-A 1-97 (101) alignment 
Range on Protein: 14-112
Range on HMM: 1-97/101.0
VLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFDISEQEVTAPAPAACQILKE--QGLRPYLLIHDGVRSEFD
.|.|. |||..    | .|| |..||. .|...  .| ..||.|.||..|.. .|..||.|..|..|  .| || ..||.  .. . ...  .|.|.|..
flfDvdGvLwr....gdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkadkkvlvigeeglreelk

Q
.
e
subfamily_PGP_pd Subfamily PGP 117-241 1.1e-18 58.5 In-house 129-252 (279) alignment 
Range on Protein: 117-241
Range on HMM: 129-252/279.0
NPNCVvIADAGESFSYQNMNNAFQVLMELEkPVLISLGKGRYYKETS-GLMLDVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDD
. ..| . .  | .||. . .| ..| | |  ...   . . ..  .   . . |. ..|.| | | |. |.|||... ... |..  .. ....|||| 
dvgAV.vvgvdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDr

IVGDVGGAQRCGMRALQVRTGKFRRD
.  |.  ...||...| | .|  .  
lktDilfgkncGlqtLlvlsGvtkle
subfamily_PGP_pd Subfamily PGP 14-113 2.8e-17 53.9 In-house 2-100 (279) alignment 
Range on Protein: 14-113
Range on HMM: 2-100/279.0
VLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGFD-ISEQEVTAPAPAACQILKEQGLRP--YLLIHDGVRSEF
||.|. |||      | ||| |..||...||.   || |.||.| |||.||. ....|||. ..|.|.  .| |... ||..  .   |.| ..|...| 
vlfDcDGVlWl....getaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqkkfekkvyvlgeeglkeeL

DQI
.. 
kea
Hydrolase_like HAD-hyrolase-like 187-245 1e-15 48.7 Pfam-A 2-60 (75) alignment 
Range on Protein: 187-245
Range on HMM: 2-60/75.0
VGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQRCGMRALQVRTGKFRRDRAPL
 |||.|.....||.  |... ..|||||..  |. .|...|.|.. |.|| .|.... |
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl
Chronophin_2 13-109 1.1e-11 35.6 In-house 2-98 (282) alignment 
Range on Protein: 13-109
Range on HMM: 2-98/282.0
GVLLDISGVLYDsgagGGTAIAGSVEAVARLKRSRLKVRFCTNESQKSRAELVGQLQRLGF-DISEQEVTAPAPAACQILKEQG---LRPYLLIHDGVRS
.||.|  ||...    | .|.||..| | ||.|   .| | ||.|...| ..| .. |||| |. .... . |  . ..|..      . . .  .|.| 
nvlfdcdgviwn....gekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadvrgkvfviggeglrk

E
|
e
Chronophin_2 126-237 1.1e-11 35.5 In-house 133-244 (282) alignment 
Range on Protein: 126-237
Range on HMM: 133-244/282.0
AGESFSYQNMNNAFQVLMELEkPVLISLGKGRYYKETSGLML-DVGPYMKALEYACGIKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIVGDVGGAQ
  |.... .. .|   | . .  .|..  .  ..  ..| ..   |    ||| | | || |.||||. .|.   . . |.  ...|||| .  |.   .
ydekltflklakacaylrdad.clllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdrletdilfgs

RCGMRALQVRTGK
.||. ..   || 
ncglstvltltgv
HAD_2 Haloacid dehalogenase-like hydrolase 187-233 1.7e-09 29.5 Pfam-A 131-176 (176) alignment 
Range on Protein: 187-233
Range on HMM: 131-176/176.0
VGKPSPEFFKSALQAIGVEAHQAVMIGDDIvGDVGGAQRCGMRALQV
. ||.||... .|. .|| ......|.| .  || .|. .|.|. .|
apKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
Hydrolase haloacid dehalogenase-like hydrolase 182-227 2.3e-07 22.7 Pfam-A 171-215 (215) alignment 
Range on Protein: 182-227
Range on HMM: 171-215/215.0
IKAEVVGKPSPEFFKSALQAIGVEAHQAVMIGDDIvGDVGGAQRCG
..|||||||.|. |  |... ........|.||..  |. .....|
vfaevvgkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg