Gene MbreMKP-Un-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP002_AA protein Get Run
MbreP002_AA_213-357 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 209-358 1.3e-55 181.0 In-house 2-143 (148) alignment
Range on Protein: 209-358
Range on HMM: 2-143/148.0
NLAALPSQLH-RHLFVGSRPFEASAERLAQLGVAAVVTHNRpERRNILDVRgqvelvnGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ
.|  .||...  .||.||....|..|.|..|||...|.... ||.|.||.|       ||||||.||.| .|.||..|||.....|.....|.||.||..
aLrtfpseikdafLFlGskksaadlealkalgvtrivnatk.erdnaldqr.......gieYlhvaldD.kpkedlsaiFediiafvrkakdeGrrvLvh

LH-GRSQSAALGLFWYCLHERVSVPLALAAVDSATRFrVDHRLMYLSQLYHL
|. |.|.|.||.|.|.. ..|||...|||.|.|..|. ||..|..|.||..|
lqmGvsrssalallwlidfkrvslkealalvkskrry.vdpnlgfLkqLael

0044763 (Phosphotyrosine protein) phosphatases II 214-357 5.9e-11 37.8 In-house 23-165 (178) alignment
Range on Protein: 214-357
Range on HMM: 23-165/178.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNILDVRGQVELVNGIEYLHLALRDSDPREdVRAIFPPAADFITRHV-DAGRTVLIQ-LHGR
.|.   .|..|| | ..  | | .||. ..|. . . ... |.   .    .||.|||. . |... . ....|. . .|| ... . |..||.   .|.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGv

SQSAALGLFWYCLHERVSVPLALAAVDsATRFrVDHRLMYLSQLYH
. |..| . ..... ..|.. |.. |  . |. .  .  .| ||| 
gRsgtlvaaylmkklglsleeaielvr.erRp.ivpnpgqlrqLye

PTPc_motif_SM00404 214-357 2.3e-09 32.3 In-house 2-136 (140) alignment
Range on Protein: 214-357
Range on HMM: 2-136/140.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNildvrgqvELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||. ..||..|| . . ... |..||. .|.   .  . .        .  .|...|.. |.| .  ... . .. ..||| .  . |..||.   .| |
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqipldd.nekdklskyldkvldfienaekkggkvlVHCqaGvS

QSAALGLFWYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
 ||.| ....   . .|.  |. .| .  | .....| .. ||. 
RSatliiaYlmryrqlslaeayefv.kerRpiispnlnfvrqLie

subfamily_DSP3_pd Subfamily DSP3 218-341 1e-08 29.0 In-house 15-138 (162) alignment
Range on Protein: 218-341
Range on HMM: 15-138/162.0
HRHLFVGSRPFEASAERLAQLGVAAVVTHNRPeRRNILDVRGQVELVNGIEYLHLALRDSdPREDVRAIFPPAADFITRHVDA--GRTVLIQLHGRSQSA
. .|.|| .      ..|..||.. |.   .  | .  |   .     .|.|| | ..|. |. |... | .||.|| . ..   |. ..    | | ||
ypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDv.pefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

ALGLFWYCLHERVSVPLALAAVDSAT
.| | .  .......  |. .| .  
tlvlayLmirrkmtlveairtvrkkR

0048179 (Phosphotyrosine protein) phosphatases II 214-341 1.4e-08 30.1 In-house 4-124 (144) alignment
Range on Protein: 214-341
Range on HMM: 4-124/144.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNILDVRgqvelvnGIEYLHLALRDSDPReDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||.   .|..|| |.  . |.|..||. .|.. . .   . | .        ||.|||| . | ..  |  .... . .|| .... |. ||.   .|..
pseilpglylgslptaldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvp.dllellleflefieealeeggpvlVHCsaGvg

QSAALGLFWYCLHERVSVPLALAAVDSAT
 ...| . . ......|.  ||| | |. 
Rtgtlvaaylmkklglsleealalvrsrr

subfamily_DSP8_pd Subfamily DSP8 214-355 1.7e-08 28.2 In-house 15-147 (159) alignment
Range on Protein: 214-355
Range on HMM: 15-147/159.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERrnildvrgQVELVNGIEYLHLALRDSDpREDVRAIFPPAADFITRHVDAGRTVLIQLH-GRS
| .. ..|..||.    | | | .||.. |.  ..           ..| ..  ..|.. ..|.   |..  .|. . .|| . . .  .||.  . |.|
ptrilknlylGsqkdvlseellsklgisyvlnasnscp........kleelkeskflrvPvkDky.dekllpwfdksvefidkaksengrvlvhvlaGis

QSAALGLFWYCLHERVSVPLALAAVDSATrFRVDHRLMYLSQL
.||.. . .   . ..|.  |   | .     ..  | .| ||
rsatvaiayimktlemsldeayrfvkekr.ptispnlnflgqL

0048076 (Phosphotyrosine protein) phosphatases II 214-357 6.2e-08 28.0 In-house 4-137 (145) alignment
Range on Protein: 214-357
Range on HMM: 4-137/145.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHnrperrnilDVRGQVELVNGIEYLHLALRDSDPReDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||.   .|..|| |   . |.|..||. .|..              . .  .||.||.| . | ..  |  .... . .|| .....|. ||.   .|..
pseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvp.dllellleflefieealkeggpvlVHCsaGvg

QSAALGLFWYCLHERVSVPLALAAVDSAtRFRVDHRLMYLSQLYH
 ...| . . .|...||.. ||. | |. |. .  .  .| .|| 
Rtgtlvaaylmlllgvsleealelvrsq.rpgavpnpgqlrflye

subfamily_DSP1_pd Subfamily DSP1 214-334 1.1e-07 26.0 In-house 17-129 (163) alignment
Range on Protein: 214-334
Range on HMM: 17-129/163.0
PSQ-LHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPeRRNILDVrgqvelvnGIEYLHLALRDSdPREDVRAIFPPAADFITRHVDAGRTVLIQLH-GR
|.. .  .|..||.   .  | |..||..|..   .    |. .           || .| |.|| |..|. ..| .. .|| .  ...  |||  . | 
PvekildfLylGsetvasnleiLkslgitailnvske.ldnvfed........lfeYkklkleDs.pkadislvfeeviefidevkkknGkvlihCqaGi

SQSAALGLFWYCLHERVSVPLAL
| |..| | .   ..|||.  | 
sRsstlclaylmktkrvsleeaf

0046846 (Phosphotyrosine protein) phosphatases II 215-342 2.8e-07 26.0 In-house 13-152 (176) alignment
Range on Protein: 215-342
Range on HMM: 13-152/176.0
SQLHRHLFVGSRP----------FEASAERLAQLGVAAVVTHNRPERRNILD--VRGQVELVNGIEYLHLALRDSDPREDvrAIFPPAADFITRHVDAGR
.... .|..||||          ...  |.| .||. |||. . .   . |.     ...  .||.||||  .| .. ..  .... . .|| .....|.
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl..elllellefirealkegg

TVLIQ-LHGRSQSAALGLFWYCLH-ERVSVPLALAAVDSATR
.||.   .|.. ...| . . . .   .||  ||| | .  .
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRp

DSPc Dual specificity phosphatase, catalytic domain 222-357 8.6e-07 23.9 Pfam-A 2-129 (133) alignment
Range on Protein: 222-357
Range on HMM: 2-129/133.0
FVGSRPFEAsAERLAQLGVAAVVTHNRPERRNildvrgQVELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRSQSAALGLF
..|| . .   . |..||. .|.   .  . |      .    . ||||.. ..| .  ... . .. | .|| .  . |..||.   .| | ||.| . 
ylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia

WYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
..   ...|.  |...| .  | .. ..  .| ||. 
YlmktknlslneAyefv.kerrskispnagflrqLle

DSPc Dual specificity phosphatase, catalytic domain 222-357 8.6e-07 23.9 In-house 2-129 (133) alignment
Range on Protein: 222-357
Range on HMM: 2-129/133.0
FVGSRPFEAsAERLAQLGVAAVVTHNRPERRNildvrgQVELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRSQSAALGLF
..|| . .   . |..||. .|.   .  . |      .    . ||||.. ..| .  ... . .. | .|| .  . |..||.   .| | ||.| . 
ylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia

WYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
..   ...|.  |...| .  | .. ..  .| ||. 
YlmktknlslneAyefv.kerrskispnagflrqLle

subfamily_DSP14_pd Subfamily DSP14 215-339 1.3e-06 22.5 In-house 8-122 (157) alignment
Range on Protein: 215-339
Range on HMM: 8-122/157.0
SQLHRHLFVGSRPfEASAERLAQLGVAAVVTHNRperrnilDVRGqvELVNGIEYLHLALRDSdPREDVRAIFPPAADFITR-HVDAGRTVLIQLHGRSQ
||. ..||....    | | |.. ......   .       ..    . ...||.......|. |.... . | ..|| |   . ..|.|..    |.| 
sqitpsLflsgva.alskellkkkkitliinvtv.......elpn..tklkdiervkvpveDn.peaklakhfdevadkieevkkkggktlvhCvaGvSR

SAALGLFWYCLHERVSVPLALAAVDS
||.| | .   .|..|   |  .| |
SAslclaylmkyeklsLreayklvks

subfamily_PTPMT1_pd Subfamily PTPMT1 215-340 1.9e-06 22.4 In-house 21-147 (171) alignment
Range on Protein: 215-340
Range on HMM: 21-147/171.0
SQLHRHLFVGSRPFEASAERL-AQLGVAAVVTHNRPER-RNILDVRGQVElVNGIEYLHLALRDSDPREDVRAIFpPAADFITRHVDAGRTVLIQLH-GR
...  ....|  ||.  ...|  .  |.|||. |   . . . .   . .  .|.|.|.||  |     |.  ..  . .||... . |..| .  . ||
driDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewk.klgveqlqlatvDfteapdlekle.kgvefiekvaskgkrvYvHCkaGr

SQSAALGLFWYCLHERVSVPLALAAVDSA
. ||.|   .  ..|..|   || |. . 
gRsatlvacylmkkeklspeeAlkalkkk