Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_Choan-DSP_MKP-1_pd | Subfamily Choan-DSP_MKP-1 | 209-358 | 1.3e-55 | 181.0 | In-house | 2-143 (148) | alignment | ||
Range on Protein: 209-358
Range on HMM: 2-143/148.0
NLAALPSQLH-RHLFVGSRPFEASAERLAQLGVAAVVTHNRpERRNILDVRgqvelvnGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ
.| .||... .||.||....|..|.|..|||...|.... ||.|.||.| ||||||.||.| .|.||..|||.....|.....|.||.||..
aLrtfpseikdafLFlGskksaadlealkalgvtrivnatk.erdnaldqr.......gieYlhvaldD.kpkedlsaiFediiafvrkakdeGrrvLvh
LH-GRSQSAALGLFWYCLHERVSVPLALAAVDSATRFrVDHRLMYLSQLYHL
|. |.|.|.||.|.|.. ..|||...|||.|.|..|. ||..|..|.||..|
lqmGvsrssalallwlidfkrvslkealalvkskrry.vdpnlgfLkqLael
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 214-357 | 5.9e-11 | 37.8 | In-house | 23-165 (178) | alignment | ||
Range on Protein: 214-357
Range on HMM: 23-165/178.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNILDVRGQVELVNGIEYLHLALRDSDPREdVRAIFPPAADFITRHV-DAGRTVLIQ-LHGR
.|. .|..|| | .. | | .||. ..|. . . ... |. . .||.|||. . |... . ....|. . .|| ... . |..||. .|.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGv
SQSAALGLFWYCLHERVSVPLALAAVDsATRFrVDHRLMYLSQLYH
. |..| . ..... ..|.. |.. | . |. . . .| |||
gRsgtlvaaylmkklglsleeaielvr.erRp.ivpnpgqlrqLye
|
|||||||||
| PTPc_motif_SM00404 | 214-357 | 2.3e-09 | 32.3 | In-house | 2-136 (140) | alignment | |||
Range on Protein: 214-357
Range on HMM: 2-136/140.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNildvrgqvELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||. ..||..|| . . ... |..||. .|. . . . . .|...|.. |.| . ... . .. ..||| . . |..||. .| |
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqipldd.nekdklskyldkvldfienaekkggkvlVHCqaGvS
QSAALGLFWYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
||.| .... . .|. |. .| . | .....| .. ||.
RSatliiaYlmryrqlslaeayefv.kerRpiispnlnfvrqLie
|
|||||||||
| subfamily_DSP3_pd | Subfamily DSP3 | 218-341 | 1e-08 | 29.0 | In-house | 15-138 (162) | alignment | ||
Range on Protein: 218-341
Range on HMM: 15-138/162.0
HRHLFVGSRPFEASAERLAQLGVAAVVTHNRPeRRNILDVRGQVELVNGIEYLHLALRDSdPREDVRAIFPPAADFITRHVDA--GRTVLIQLHGRSQSA
. .|.|| . ..|..||.. |. . | . | . .|.|| | ..|. |. |... | .||.|| . .. |. .. | | ||
ypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDv.pefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa
ALGLFWYCLHERVSVPLALAAVDSAT
.| | . ....... |. .| .
tlvlayLmirrkmtlveairtvrkkR
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 214-341 | 1.4e-08 | 30.1 | In-house | 4-124 (144) | alignment | ||
Range on Protein: 214-341
Range on HMM: 4-124/144.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERRNILDVRgqvelvnGIEYLHLALRDSDPReDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||. .|..|| |. . |.|..||. .|.. . . . | . ||.|||| . | .. | .... . .|| .... |. ||. .|..
pseilpglylgslptaldlellkklgittvinlteeyepeflere.......giqylhlpwpDhgvp.dllellleflefieealeeggpvlVHCsaGvg
QSAALGLFWYCLHERVSVPLALAAVDSAT
...| . . ......|. ||| | |.
Rtgtlvaaylmkklglsleealalvrsrr
|
|||||||||
| subfamily_DSP8_pd | Subfamily DSP8 | 214-355 | 1.7e-08 | 28.2 | In-house | 15-147 (159) | alignment | ||
Range on Protein: 214-355
Range on HMM: 15-147/159.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPERrnildvrgQVELVNGIEYLHLALRDSDpREDVRAIFPPAADFITRHVDAGRTVLIQLH-GRS
| .. ..|..||. | | | .||.. |. .. ..| .. ..|.. ..|. |.. .|. . .|| . . . .||. . |.|
ptrilknlylGsqkdvlseellsklgisyvlnasnscp........kleelkeskflrvPvkDky.dekllpwfdksvefidkaksengrvlvhvlaGis
QSAALGLFWYCLHERVSVPLALAAVDSATrFRVDHRLMYLSQL
.||.. . . . ..|. | | . .. | .| ||
rsatvaiayimktlemsldeayrfvkekr.ptispnlnflgqL
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 214-357 | 6.2e-08 | 28.0 | In-house | 4-137 (145) | alignment | ||
Range on Protein: 214-357
Range on HMM: 4-137/145.0
PSQLHRHLFVGSRPFEASAERLAQLGVAAVVTHnrperrnilDVRGQVELVNGIEYLHLALRDSDPReDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRS
||. .|..|| | . |.|..||. .|.. . . .||.||.| . | .. | .... . .|| .....|. ||. .|..
pseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvp.dllellleflefieealkeggpvlVHCsaGvg
QSAALGLFWYCLHERVSVPLALAAVDSAtRFRVDHRLMYLSQLYH
...| . . .|...||.. ||. | |. |. . . .| .||
Rtgtlvaaylmlllgvsleealelvrsq.rpgavpnpgqlrflye
|
|||||||||
| subfamily_DSP1_pd | Subfamily DSP1 | 214-334 | 1.1e-07 | 26.0 | In-house | 17-129 (163) | alignment | ||
Range on Protein: 214-334
Range on HMM: 17-129/163.0
PSQ-LHRHLFVGSRPFEASAERLAQLGVAAVVTHNRPeRRNILDVrgqvelvnGIEYLHLALRDSdPREDVRAIFPPAADFITRHVDAGRTVLIQLH-GR
|.. . .|..||. . | |..||..|.. . |. . || .| |.|| |..|. ..| .. .|| . ... ||| . |
PvekildfLylGsetvasnleiLkslgitailnvske.ldnvfed........lfeYkklkleDs.pkadislvfeeviefidevkkknGkvlihCqaGi
SQSAALGLFWYCLHERVSVPLAL
| |..| | . ..|||. |
sRsstlclaylmktkrvsleeaf
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 215-342 | 2.8e-07 | 26.0 | In-house | 13-152 (176) | alignment | ||
Range on Protein: 215-342
Range on HMM: 13-152/176.0
SQLHRHLFVGSRP----------FEASAERLAQLGVAAVVTHNRPERRNILD--VRGQVELVNGIEYLHLALRDSDPREDvrAIFPPAADFITRHVDAGR
.... .|..|||| ... |.| .||. |||. . . . |. ... .||.|||| .| .. .. .... . .|| .....|.
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl..elllellefirealkegg
TVLIQ-LHGRSQSAALGLFWYCLH-ERVSVPLALAAVDSATR
.||. .|.. ...| . . . . .|| ||| | . .
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRp
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 222-357 | 8.6e-07 | 23.9 | Pfam-A | 2-129 (133) | alignment | ||
Range on Protein: 222-357
Range on HMM: 2-129/133.0
FVGSRPFEAsAERLAQLGVAAVVTHNRPERRNildvrgQVELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRSQSAALGLF
..|| . . . |..||. .|. . . | . . ||||.. ..| . ... . .. | .|| . . |..||. .| | ||.| .
ylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia
WYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
.. ...|. |...| . | .. .. .| ||.
YlmktknlslneAyefv.kerrskispnagflrqLle
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 222-357 | 8.6e-07 | 23.9 | In-house | 2-129 (133) | alignment | ||
Range on Protein: 222-357
Range on HMM: 2-129/133.0
FVGSRPFEAsAERLAQLGVAAVVTHNRPERRNildvrgQVELVNGIEYLHLALRDsDPREDVRAIFPPAADFITRHVDAGRTVLIQ-LHGRSQSAALGLF
..|| . . . |..||. .|. . . | . . ||||.. ..| . ... . .. | .|| . . |..||. .| | ||.| .
ylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliia
WYCLHERVSVPLALAAVdSATRFRVDHRLMYLSQLYH
.. ...|. |...| . | .. .. .| ||.
YlmktknlslneAyefv.kerrskispnagflrqLle
|
|||||||||
| subfamily_DSP14_pd | Subfamily DSP14 | 215-339 | 1.3e-06 | 22.5 | In-house | 8-122 (157) | alignment | ||
Range on Protein: 215-339
Range on HMM: 8-122/157.0
SQLHRHLFVGSRPfEASAERLAQLGVAAVVTHNRperrnilDVRGqvELVNGIEYLHLALRDSdPREDVRAIFPPAADFITR-HVDAGRTVLIQLHGRSQ
||. ..||.... | | |.. ...... . .. . ...||.......|. |.... . | ..|| | . ..|.|.. |.|
sqitpsLflsgva.alskellkkkkitliinvtv.......elpn..tklkdiervkvpveDn.peaklakhfdevadkieevkkkggktlvhCvaGvSR
SAALGLFWYCLHERVSVPLALAAVDS
||.| | . .|..| | .| |
SAslclaylmkyeklsLreayklvks
|
|||||||||
| subfamily_PTPMT1_pd | Subfamily PTPMT1 | 215-340 | 1.9e-06 | 22.4 | In-house | 21-147 (171) | alignment | ||
Range on Protein: 215-340
Range on HMM: 21-147/171.0
SQLHRHLFVGSRPFEASAERL-AQLGVAAVVTHNRPER-RNILDVRGQVElVNGIEYLHLALRDSDPREDVRAIFpPAADFITRHVDAGRTVLIQLH-GR
... ....| ||. ...| . |.|||. | . . . . . . .|.|.|.|| | |. .. . .||... . |..| . . ||
driDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewk.klgveqlqlatvDfteapdlekle.kgvefiekvaskgkrvYvHCkaGr
SQSAALGLFWYCLHERVSVPLALAAVDSA
. ||.| . ..|..| || |. .
gRsatlvacylmkkeklspeeAlkalkkk
|
|||||||||