Gene MbreMKP-Un-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP004_AA protein Get Run
MbreP004_AA_280-427 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0044763 (Phosphotyrosine protein) phosphatases II 281-422 7.5e-32 105.8 In-house 21-169 (178) alignment 
Range on Protein: 281-422
Range on HMM: 21-169/178.0
SSLSDVWQGsIYIGCVHDATDRDLLTRTGITHVLSALED--------CPEVPMS--IEQLHLPISDTFSSEfeVLPSFLRGAQFIHEAV-SAGGRVLVHC
  .| .. | .|.|.  .| |..|| . ||||...  |.        .|. |..  |. ||.||.|    .  .|  ||.  .||.||. . ||.|||||
inaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd..llehflefvefieealdekggpvlVHC

AAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQvVSPNLAFLGVLLTMEQQ
 |||.||.|.|||||......|.|  |..... |  ..||  .|  |. .|..
saGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP10_pd Subfamily DSP10 291-424 3.8e-30 98.9 In-house 21-154 (159) alignment 
Range on Protein: 291-424
Range on HMM: 21-154/159.0
IYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPMS--IEQLHLPISDTFSSEfeVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYH
...|  .||.| |.| | .||.||    ..|       ..  ..|.||| . .  .   |    .||.|| . | |||||| ||.||| |.| |||. . 
LflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqn..lkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhl

NMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQRN
|.|.. .  . .  | ..||||.|.| || .|.. |
nlslndaykfvkekrpiisPnLnfmGqLlefekeln
PTPc_motif_SM00404 289-421 3.6e-29 96.4 In-house 7-139 (140) alignment 
Range on Protein: 289-421
Range on HMM: 7-139/140.0
GSIYIGCVHDATDRDLLTRTGITHVLSALEDCPE--VPMSIEQLHLPISDtfSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
. .|.|   .|....||.  |||||... | ..      ... |..|..|  . . .... . . ..||..| . ||.|||||.|||||| |...|||. 
phlylgskskaqnpallkklgithvinvteevsltkensgfqilqipldd..nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

YHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
|...|.. ... ..  |. .|||| |.  |. .|.
yrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP8_pd Subfamily DSP8 290-421 6.3e-29 94.6 In-house 21-152 (159) alignment 
Range on Protein: 290-421
Range on HMM: 21-152/159.0
SIYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPMSIE--QLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILY
 .|.|. .|. ...||...||..|| | . ||.. .  |   |..|. |...   ..|| | .  .||  |.|. ||||||. || |||.|.. ||.. .
nlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkyde..kllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

HNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
 .||.. .  ...  |...|||| ||| ||  |.
lemsldeayrfvkekrptispnlnflgqLleyek
0048076 (Phosphotyrosine protein) phosphatases II 287-422 1.8e-28 94.4 In-house 8-141 (145) alignment 
Range on Protein: 287-422
Range on HMM: 8-141/145.0
WQGsIYIGCVHDATDRDLLTRTGITHVLSALEDCPEV-PMSIEQLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLI
..| .|.|....| |..|| . |||.||.   ... . .. |. |.||. |      . |  .|.  .||.||...||.||||| |||.|..|.|||||.
lpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvp..dllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQ
|....|.|  . .... |  . ||  .|  |.  |..
lllgvsleealelvrsqrpgavpnpgqlrflyefele
DSPc Dual specificity phosphatase, catalytic domain 291-421 2.3e-28 93.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 291-421
Range on HMM: 1-132/133.0
IYIGCVHDATdRDLLTRTGITHVLSALEDCPE----VPMSIEQLHLPISDtfSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
.|.|   .|.  .||.  |||.|... . .|.     . .||.|..|. |  ..| .. . . .  .||..| . |..|||||.||.|||.|...|||. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmk

YHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
..|.|..  .....  |. .|||  ||. || .|.
tknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 291-421 2.3e-28 93.7 In-house 1-132 (133) alignment 
Range on Protein: 291-421
Range on HMM: 1-132/133.0
IYIGCVHDATdRDLLTRTGITHVLSALEDCPE----VPMSIEQLHLPISDtfSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
.|.|   .|.  .||.  |||.|... . .|.     . .||.|..|. |  ..| .. . . .  .||..| . |..|||||.||.|||.|...|||. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmk

YHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
..|.|..  .....  |. .|||  ||. || .|.
tknlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP14_pd Subfamily DSP14 289-427 2.6e-28 92.9 In-house 12-148 (157) alignment 
Range on Protein: 289-427
Range on HMM: 12-148/157.0
GSIYIGcVHDATDRDLLTRTGITHVLSALEDCPEVPMS-IEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILY
 |....    |....||....||... .  . |. ... ||....|..|.  .| .. . | . |. |.|.  .||..||||.|||||| ... |||. |
psLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDn..peaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmky

HNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQRNDGR
...|.. . ..... | ...||. |   | . |.. ..  
eklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP1_pd Subfamily DSP1 290-423 2.8e-28 93.0 In-house 24-156 (163) alignment 
Range on Protein: 290-423
Range on HMM: 24-156/163.0
SIYIGCVHDATDRDLLTRTGITHVLSALEDCPEV-PMSIEQLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYH
 .|.|  ..|.....|...|||..| . .....| .   |  .|...|. .   ..   | .  .||.|. ...|.||.||.||.||| |.. |||.  .
fLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspka..dislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktk

NMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQR
..|.|      .  |...|||..| . ||. |.. 
rvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0048179 (Phosphotyrosine protein) phosphatases II 286-421 5e-28 93.0 In-house 7-142 (144) alignment 
Range on Protein: 286-421
Range on HMM: 7-142/144.0
VWQGsIYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPM---SIEQLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAA
...| .|.|.. .| | .|| . |||.|..  |...   .    |. ||||. |      . |  .|.  .||.||.. ||.||||| |||.|..|.|||
ilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvp..dllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
||......|.|  . .... |  . ||  .|  ||  |.
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP19_pd Subfamily DSP19 289-423 9.9e-28 91.4 In-house 17-150 (152) alignment 
Range on Protein: 289-423
Range on HMM: 17-150/152.0
GSIYIGCVHDATDRDLLTRTGITHVLSALEDCPEV-PMSIEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILY
 ..|.| .  |.|.. | ...|||.|.   . |.| |  .. |...| |.  .| ..|  . .  .||.|| |. |.||||| ||||||...| |||.  
prlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDl..petdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkk

HNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQR
...|.|.... ... |. ..||  |.  | ..|.. 
eelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP3_pd Subfamily DSP3 282-423 4.6e-27 88.6 In-house 10-157 (162) alignment 
Range on Protein: 282-423
Range on HMM: 10-157/162.0
SLSDVWQgSIYIGCVHDATDRDLLTRTGITHVLSALED-CPEV--------PMSIEQLHLPISDTFSSEFEVlpSFLRGAQFIHEAVSA-GGRVLVHCAA
.. .|.. ..|.|  . |.|.. |.. |||||| | |    .|         ..|. | |...|........   | . |.||.||.|   |.|||||..
evdevyp.klyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlsk..yFetaakfidealsqkegkvlvhcvv

GVSRSPTMVAAYLILYHNMSMETSISHLQALRQVvSPNLAFLGVLLTMEQQR
|||||.|.| |||.....|..   |.. .. |..  ||  ||  | ..... 
GvsRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeel
0046846 (Phosphotyrosine protein) phosphatases II 289-422 7.2e-27 89.7 In-house 17-171 (176) alignment 
Range on Protein: 289-422
Range on HMM: 17-171/176.0
GSIYIGCVH----------DATDRDLLTRTGITHVLSALED------------CPEVPMSIEQLHLPISDTFSSEFevlPSFLRGAQFIHEAVSAGGRVL
.....|.             |.. ..| . |||.|.. .|.              .  ..|. ||||. |    ..     .|.  .||.||...||.||
anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl...elllellefirealkeggpvl

VHCAAGVSRSPTMVAAYLILY-HNMSMETSISHLQALRQ-VVSPNLAFLGVLLTMEQQ
||| ||..|..|.|||||. . ...|.|  ...... |   . .. ...  |  .|..
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 292-423 1.8e-26 88.3 In-house 27-160 (172) alignment 
Range on Protein: 292-423
Range on HMM: 27-160/172.0
YIGCVHDATDRDLLTRTGITHVLSALE----DCPEVPMSIEQLHLPISDTFSSefeVLPSFLRGAQFIHE--AVSAGGRVLVHCAAGVSRSPTMVAAYLI
. .. ..| ....| . ||||.... |      ..... |. |.||. |        |  .|.  .||.|  |.| ||.||||| |||.|..|.|||||.
gplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

LyHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQR
| ...|.|  ...... |  ...|  ..  |.  |...
l.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP6_pd Subfamily DSP6 290-422 3.7e-26 85.5 In-house 20-153 (158) alignment 
Range on Protein: 290-422
Range on HMM: 20-153/158.0
SIYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPMSIE---QLHLPISDTFSSEFEvlPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
 .|.|. .||.....|.. .| .||   .. |..  . .    |..||.| .| ..     |    .|| || |.   ||||| ||.||| |.. |||. 
llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnla..kffPeaiefidearskkskvlvhClaGisrsvtvtlaylmk

YHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQ
....|.. .   ... .  .|||. |.| ||  |..
klalslndaydlvkkrksnisPnfnfmgqlldfers
0041856 (Phosphotyrosine protein) phosphatases II 289-424 5.9e-26 86.6 In-house 24-173 (182) alignment 
Range on Protein: 289-424
Range on HMM: 24-173/182.0
GSIYIGCVHD--------------ATDRDLLTRTGITHVLSALEDC----PEVPMSIEQLHLPISDTFSSEfevlpsFLRGAQFIHEAVSAGGRVLVHCA
 ..|.|. ..              | . ..| . |||..... |..     .  . |. |.||. |    .      .    .||.|. . ||.||||| 
anlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd......ldelldfieevleeggpvlVHCs

AGVSRSPTMVAAYLILYHNMSMETSISHLQALRQ--VVSPNLAFLGVLLTMEQQRN
|||.|..|.|||||......|.|  .....  |   |..||  |.  |. .| ...
aGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_DSP15_pd Subfamily DSP15 290-421 6e-26 85.4 In-house 8-137 (151) alignment 
Range on Protein: 290-421
Range on HMM: 8-137/151.0
SIYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPMSIEQLHLPISDTFSSEFEVlpSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHN
 .|.| ..|. |..||... |||.||  ..  ..   || . ...||| | ...    |    .|||.. . .. |||||.|||||| |.|.|||.   .
glylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklsk..ffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvte

MSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
.. . ... ..| |.|  ||. |   |   |.
lnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP12_pd Subfamily DSP12 289-417 2e-25 84.0 In-house 7-137 (155) alignment 
Range on Protein: 289-417
Range on HMM: 7-137/155.0
GSIYIGCVHDATDRDLLTRTGITHVLSALEDC----PEVPMSIEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYL
. .|.| ...... .||. ..||||||  .       . .  .......| |.   | ..|  . .  .||.||.. .| |||||.|||||| |.|.|||
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDe..peediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

ILYHNMSMETSISHLQALRQVVSPNLAFLGVLL
. ....|.|. .. ... .. ..||  ||  | 
mkkeklslekAlklvkekkpeiepNegFleQLk
0049772 (Phosphotyrosine protein) phosphatases II 296-422 6.7e-25 83.9 In-house 157-272 (314) alignment 
Range on Protein: 296-422
Range on HMM: 157-272/314.0
VHDATDRDLLTrtgithvlSALEDCPEVPMS-IEQLHLPISDtFSSEfeVLPSFLRGAQFIHEAvSAGGRVLVHCAAGVSRSPT-MVAAYLILYHNMSME
  .| | .||         . | | . ..   |. |..|..| .|     |  |..  .||.|| ..||.|||||.||..|..| .|||||......|.|
eptaadlellk........eelydpelferlgikylripvpD.gsap..lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsle

TSISHLQALRQvVSPNLAFLGVLLTMEQQ
. ...... |  ..||  |.  |. .|..
ealedvrlkRp.inpnpgfieqleqyefi
0049260 (Phosphotyrosine protein) phosphatases II 291-421 4.2e-24 80.4 In-house 15-147 (152) alignment 
Range on Protein: 291-421
Range on HMM: 15-147/152.0
IYIGCVHDATDRDLLTRTGITHVLSALEDCPE----VPMSIEQLHLPISDTFSSEFEVLPSFLRGAQFIHeAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
...|. . | . ..| . |||....  |...     ... |. ||||. |    ... |  ||  .  .. | . ||.||||| |||.|..|.|||||.|
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml

yHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
 ...|.|  ...... | .. ||  .|  |.  |.
.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 284-422 6.8e-24 78.1 In-house 8-146 (148) alignment 
Range on Protein: 284-422
Range on HMM: 8-146/148.0
SDVWQGSIYIGCVHDATDRDLLTRTGITHVLSALEDCPEV--PMSIEQLHLPISDtfSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVA
|..... ...|  . |.| . |   |.|.. .| .... .    .|| ||....|    ....   |   ..|...|...|.|||||.  |||||  .. 
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldD..kpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalal

AYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQ
..|| ....|..  .   .  |. | ||| ||  |  .||.
lwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0045098 (Phosphotyrosine protein) phosphatases II 289-421 8.4e-24 79.8 In-house 27-269 (278) alignment 
Range on Protein: 289-421
Range on HMM: 27-269/278.0
GSIYIGCVH-----------------------------------------DATDRDLLTRTGITHVLSALED----------------------------
 ..|.|...                                          | . ..|   |||..... |                             
palylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtll

----------------------CPEVPMSIEQLHL-PISDTFSSEFEVLPSFLRGAQFIHEAVS--------------AGGRVLVHCAAGVSRSPTMVAA
                          .. ...||. |. |  . ....| |||.  .||.||..               ||.||||| |||.|. |.|||
seevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaa

YLILYH---NMSMETSISHLQALRQV-VSPNLAFLGVLLTMEQ
||.|..   .....  ...|.  |   . .|| ..  |  ...
ylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
subfamily_MKPLT_pd Subfamily MKPLT 285-421 6.8e-23 75.0 In-house 23-158 (164) alignment 
Range on Protein: 285-421
Range on HMM: 23-158/164.0
DVWQGSIYIGCVHDATDRDLLTRTGITHVLSALEDCP-EVPMSIEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAY
 | .  .| | ...||.. .|.   |||..   ...    |.|.| | . ..|.  |. .. . . | |.|. .|. .||||||||  |.||| ..  |.
vvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvede..sdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

LILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
||...   .. . ..|.  | .|.||  ||  | ..|.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 285-421 6.8e-23 75.0 In-house 23-158 (164) alignment 
Range on Protein: 285-421
Range on HMM: 23-158/164.0
DVWQGSIYIGCVHDATDRDLLTRTGITHVLSALEDCP-EVPMSIEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAY
 | .  .| | ...||.. .|.   |||..   ...    |.|.| | . ..|.  |. .. . . | |.|. .|. .||||||||  |.||| ..  |.
vvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvede..sdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

LILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
||...   .. . ..|.  | .|.||  ||  | ..|.
LikskgwtlkeayeylkerrsivapnrGflkqlakfee
PTEN_1 287-425 8e-23 76.3 In-house 44-193 (196) alignment 
Range on Protein: 287-425
Range on HMM: 44-193/196.0
WQGSIYIGCVHDA-TDRDLLTRTGITHVLSALEDCPE----------VPMSIEQLHLPISDTFSSEFEVLPSFLrgAQFIHEAVS--AGGRVLVHCAAGV
. .. |.| ..|.  |.| |   |||.|..  |....            . .|.||.|| |   . .. |  ..  ..||. . |   |. |||||.||.
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdic..ksfiewllsdpngnvVlVHCkaGl

SRSPTMVAAYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQRND
.|| |.|||||. .......  ...... | ...|| ...  ||  ......
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0036282 (Phosphotyrosine protein) phosphatases II 290-422 1.2e-21 72.7 In-house 18-168 (174) alignment 
Range on Protein: 290-422
Range on HMM: 18-168/174.0
SIYIGCVHDAtDRDLLTRTGITHVLSALEDCPE----------------VPMSIEQLHLPISDTFSSEFEVlpsFLRGAQFIHEAVSA--GGRVLVHCAA
 ...|..  | . ..| . |||.|.. || ..                 ... |. |.||. |    ....   .|.  .|..||.|   || ||||| |
rliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsa

GVSRSPTMVAAYLILYHNM-SMETSISHLQALR---QVVSPNLAFLGVLLTMEQQ
||.|..|.|||||.|.. . |..  ......||     . ..  ..  |  .|..
GvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0037934 (Phosphotyrosine protein) phosphatases II 278-421 4.5e-21 71.0 In-house 34-239 (243) alignment 
Range on Protein: 278-421
Range on HMM: 34-239/243.0
AVESSLSDVWqGSIYIGCV--------HDATDRDLLTRTGITHVLSALEDC---------------------------------------------PE-V
 .  .|..|. . ......        ..|.. ..| . |||....  |..                                             .. .
yinanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddlt

PMSIEQLHLPISDTFSSE-FEVLPSFLRGA-QFIHE-----AVSAGGRVLVHCAAGVSRSPTMVAAYLILYH-NMSMETSISHLQALRQV-VSPNLAFLG
 . |  ..||. |    . .| | .||. . .||.|     | . ||.||||| |||.|. |..||||.|.. ....|  . .|.. |   . ... .. 
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyr

VLLTMEQ
 |  ...
flyeall
0051429 (Phosphotyrosine protein) phosphatases II 286-440 1.5e-20 69.4 In-house 19-241 (272) alignment 
Range on Protein: 286-440
Range on HMM: 19-241/272.0
VWQGSIYIGCVH---DATDRDLLTRTGITHVLSALE-------DCPEVPMSIEQLHLPISDTFSSEFEVL------------------------------
|. | .| .      .| | . | . ||.....  .       .|. ..  |. ||||| |.   . ...                              
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------PSFLRGAQFIHEavsaGGRVLVHCAAGVSRSPTMVAAYLILyHNMS--------------METSISHLQALRQVVSPNLAF
                    ..|.  .....    ||.|||||.||..|. |.||..|.| ...|              .|  ...|.| |  . .. ..
arevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

LGVLLTMEQQRNDGRLSVDTTALTQHFD
.  |.  ...  .. |||.  .| ...|
ylflyeallellrsllsvraeyllaald
subfamily_LRR-DSP_pd Subfamily LRR-DSP 281-421 3.8e-20 66.1 In-house 117-256 (263) alignment 
Range on Protein: 281-421
Range on HMM: 117-256/263.0
SSLSDVWQGSIYIGCVHDATDRDLLTRTGITHVLSALEDC-PEVPMSIEQLHL-PISDTfsSEFEVLPSFLRGAQFIHEAVSAGGrVLVHCAAGVSRSPT
||. |     ...|. . |... .|   |.||.| |. |. |  |     | .  | |.   |...   | .   ||.|    || ||||| |||||| |
ssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedv..deadisqhfeetnafieeGrkkGG.vlvhcraGvsrsst

MVAAYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
.| .||. .... .. ..   .  |  . ||  |.  |.  |.
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0040439 (Phosphotyrosine protein) phosphatases II 301-421 7.7e-20 67.0 In-house 70-243 (249) alignment 
Range on Protein: 301-421
Range on HMM: 70-243/249.0
DRDLLTRTGITHVLSALEDCP--------------------------------------------EVPMSIEQLHLPISDTFssEFEVLPSFLRGAQFIH
....| . |||..... ....                                            . . |.. ||... |    .. | |||    .||.
fwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfie

EAVS------AGGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
.. .       ||.||||| |||.|..|..||||.      ......|  ...|.  |  . .|. ..  |. ...
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 283-413 1.1e-19 65.9 In-house 8-143 (151) alignment 
Range on Protein: 283-413
Range on HMM: 8-143/151.0
LSDVWQGsIYIGCVHDATDRDLLTRTGITHVLSALE-----DCPEVPM--SIEQLHLPISDTFSSEfeVLPSFLRGAQFIHEAVSA-GGRVLVHCAAGVS
.|.|. | .|..    | . .|| . ||.....  .      |||     .|| ||.|| |.      .  ||   ..|.... .  .| ||||| ||..
fsyvtgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpg..lplsfdavleflellldkkngpvlvHCsaGkg

RSPTMVAAYLILyHNMSMETSISHLQALRQ-VVSPNLAFL
|. |.||.||.| ...|.|. ...... |  || ||  ||
RTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqfl
subfamily_Slingshot_pd Subfamily Slingshot 290-418 2.3e-19 63.4 In-house 25-152 (169) alignment 
Range on Protein: 290-418
Range on HMM: 25-152/169.0
SIYIGCVHDATDRDLLTRTGITHVLSALEDCPEV-PMSIEQLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYH
 .|.|   .|.. . | ..|....|   ... .  | ..| |.. . |. ..  ..|. . .  .||..| ..| .|||||  ||||| . | || .  .
hvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeet..dllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkey

NMSMETSISHLQALRQVVSPNLAFLGVLLT
..|.|.......  |.|. || .||  | .
glsleealeyvkerrsvikPnkgflkqlee
0038934 (Phosphotyrosine protein) phosphatases II 325-425 6.3e-19 63.8 In-house 78-178 (194) alignment 
Range on Protein: 325-425
Range on HMM: 78-178/194.0
MSIEQLHLPISDT-FSSEFEVLPSFLRGAQFIHEAvSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQR
. || |.||. |  ..  .|.| .||. ....... ..|| |.||| ||..|..|.|||||| ...||.| .| ...  |. . ||  .| .||.  .. 
agieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel

ND
..
rk
0045450 (Phosphotyrosine protein) phosphatases II 304-420 8.3e-19 63.9 In-house 126-300 (307) alignment 
Range on Protein: 304-420
Range on HMM: 126-300/307.0
LLTRTGITHVLSALEDCPE-----------------------------VPMSIEQLHLPISDT-FS--------------SEFEVLPSFLRGAQFIHEAV
.| . |.|....  |...                              .  ..  ..|...|. ..               .. | |||    .||.|. 
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

S------AGGRVLVHCAAGVSRSPTMVAAYLILYHN--------MSMETSISHLQALRQVVSPNLAFLGVLLTME
.       ||.||||| |||.|..|..||||.|..         ....  ...|.. |  . .|. ..  |  ..
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 289-420 1.6e-17 59.2 In-house 52-239 (245) alignment 
Range on Protein: 289-420
Range on HMM: 52-239/245.0
GSIYIGCVHDATDRD----LLTRTGITHVLSALE-----------------------------------------------DCPEVPMSIEQLHLPISDT
. ....    . . .    .| . |||....  |                                                ..|. . |  ..||. | 
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

FSSefEVLPSFLRGAQFIHEAVS--AGGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTME
     . | ..|.  .|...|..  ..|.||||| |||.|. |..||||.      ....|.|  . .|.  |  . ... ..  |  ..
gvp..dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 307-420 1.5e-16 56.0 In-house 108-272 (317) alignment 
Range on Protein: 307-420
Range on HMM: 108-272/317.0
RTGITHVLSALEDCPE----------------------------VPMSIEQLHLPISDTFS--------------SEFEVLPSFLRGAQFIHEAVSA---
. |.|....  | ..                             .  .|. ..|...|. .               .. | ||.    .|.... .|   
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

-GGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTME
 || ||||| |||.|. |..||||.      ......|  . .|.. |  . ......  | ...
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
subfamily_STYXL1_pd Subfamily STYXL1 286-422 2.5e-16 53.3 In-house 14-152 (157) alignment 
Range on Protein: 286-422
Range on HMM: 14-152/157.0
VWQGSIYIGCVHDATDRDLLTRTGITHVLSALEDCPEVPMSIE----QLHLPISDtfSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVA
|  | .|.|  ..|... .     .  ..    |. ..  ...     ||....|  . | ..|. . .  |||.. .  |  |||    |.||| ....
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiaved..eneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavii

AYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQ
|||. ......... ..|.  .. | || ||.  |   |.|
aylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_PTPMT1_pd Subfamily PTPMT1 326-407 5.5e-16 53.5 In-house 73-152 (171) alignment 
Range on Protein: 326-407
Range on HMM: 73-152/171.0
SIEQLHLPISDTF-SSEFEVLpsfLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQVVS
 .|||.|.. | . . ..| |   ..| .||..  | | || ||| || .|| |.||.||.. ...|.|. ...|.. |. . 
gveqlqlatvDfteapdlekl...ekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir
0039614 (Phosphotyrosine protein) phosphatases II 342-421 9.3e-16 53.6 In-house 202-286 (297) alignment 
Range on Protein: 342-421
Range on HMM: 202-286/297.0
FEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
.|.| .||. .. .... . ||.||||| |||.|. |..||||.      .......  ...|.  |  . ... ..  |  ...
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 324-423 1.5e-14 47.6 In-house 53-152 (154) alignment 
Range on Protein: 324-423
Range on HMM: 53-152/154.0
PMSIEQLHLPISDTfsSEFEVLPSFLRGAQFIHEAV--SAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQ
 . || |.| . |    .|... .. .  .||..|.     ..||||. .||||| ... .||.   ..|.  ..  |.  | ...||  ||  |  .|.
gfiieylnlelfdd..vnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek

QR
..
el
subfamily_MSG5_pd Subfamily MSG5 350-418 2.1e-14 47.0 In-house 87-155 (165) alignment 
Range on Protein: 350-418
Range on HMM: 87-155/165.0
RGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQVVSPNLAFLGVLLT
| .. || | | . ..||||  |.||| ... ||.. |.|.|.. .  .|..  . .||.. ..  |. 
rltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlme
0036941 (Phosphotyrosine protein) phosphatases II 339-420 2.7e-14 48.6 In-house 178-273 (297) alignment 
Range on Protein: 339-420
Range on HMM: 178-273/297.0
SSEFEVLPSFLRGAQFIHEAVS------AGGRVLVHCAAGVSRSPTMVAAYLI--------LYHNMSMETSISHLQALRQVVSPNLAFLGVLLTME
  .. | .|.    .||... .       ||.||||| |||.|| |..||.|.         ......   . .|   |  . ..| ..  |  ..
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 292-423 6.4e-14 45.3 In-house 7-141 (145) alignment 
Range on Protein: 292-423
Range on HMM: 7-141/145.0
YIGCVHDATDRDLLTRTGITHVLS-----ALEDCPEVPMSIEQLHLPISDTFSseFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLIL
|.| .  | |  .|.  ||. ..      ..        ||| | .  .|  |  ...   |   ..||      |  |.||| |||||| |.  |.|. 
yvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedles..ydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

YHNMSMETSISHLQALRQVVSPNLAFLGVLLTMEQQR
| ||..  .   ... |    ||. ||  || .|.| 
ycnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_STYX_pd Subfamily STYX 292-418 1.4e-13 44.3 In-house 20-152 (166) alignment 
Range on Protein: 292-418
Range on HMM: 20-152/166.0
YIGCVHDATD--RDLLTRTGITHVLSALED------CPEVPMSIEQLHLPISDTFSSefEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAY
..|    |     . | . ||||..   ..       |. | ..  | | ..|.     ...  . .  .|| .... ||.||||  ||.||| ..| ||
flgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntve..niirylptvkefiddslqkggkvlvhgnagisrsaalviay

LILYHNMSMETSISHLQALRQVVSPNLAFLGVLLT
..  . .   ..  ..|  |  ..||  |   |  
imetyglkyreafayvqerrfcinpnegfvsqlke
0043336 (Phosphotyrosine protein) phosphatases II 346-417 7.5e-13 44.0 In-house 193-270 (278) alignment 
Range on Protein: 346-417
Range on HMM: 193-270/278.0
PSFLRGAQFIHEAVS-AGGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLGVLL
 ..|.  ....||..  .| ||||| |||.|. |..|.||.      ......|  ...|.  |    ... ..  | 
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
0047943 (Phosphotyrosine protein) phosphatases II 334-414 1.6e-12 42.9 In-house 176-262 (273) alignment 
Range on Protein: 334-414
Range on HMM: 176-262/273.0
ISDTFSS-EFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVSPNLAFLG
. |      .| | .|.. .. ..||.  .| |.||| |||.|. |..|..|.      .......  . .|.  |  . ... .. 
wpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0046845 (Phosphotyrosine protein) phosphatases II 336-405 2.1e-11 39.2 In-house 178-255 (284) alignment 
Range on Protein: 336-405
Range on HMM: 178-255/284.0
DTFSSEFEVLPSFLRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYH--------NMSMETSISHLQALRQV
.   ...| | .||| .. ..|... || ..||| |||.|. |..|..|.|..        .....  ...|   |  
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0051299 (Phosphotyrosine protein) phosphatases II 341-407 2.4e-10 35.8 In-house 194-269 (288) alignment 
Range on Protein: 341-407
Range on HMM: 194-269/288.0
EFEVLPSFLRGAQFIHEAVSA----GGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQVVS
.. | .|.    .|.... .|    || |.||| |||.|. |..|..|.       . ....  . .|   |  . 
dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmv
0050432 (Phosphotyrosine protein) phosphatases II 342-405 1.7e-09 32.9 In-house 210-280 (308) alignment 
Range on Protein: 342-405
Range on HMM: 210-280/308.0
FEVLPSFLRGAQFIHEAVSA--GGRVLVHCAAGVSRSPTMVAAYLI-----LYHNMSMETSISHLQALRQV
. | ||.    .|.... .   || ..||| |||.|. |..|..|.       ......  . .|   |  
hgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg
subfamily_DSP23_pd Subfamily DSP23 304-403 3.1e-09 31.7 In-house 26-125 (148) alignment 
Range on Protein: 304-403
Range on HMM: 26-125/148.0
LLTRTGITHVLSALEDCPEVPMSI---EQLHLPISDTFSSEFEVLPSFLrgaQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQ
 |   |. ...|  |...    ..      .| | |      | .  |.   . ..|| . .  | |||. |  |. ||.| ||.  ....   .|. ..
ylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefv...rvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevr

ALR
 ||
rlr
0048567 (Phosphotyrosine protein) phosphatases II 355-404 6.3e-09 30.4 In-house 67-119 (157) alignment 
Range on Protein: 355-404
Range on HMM: 67-119/157.0
IHEAVSAGGRVLVHCAAGV---SRSPTMVAAYLILYHNMSMETSISHLQALRQ
..    ||... ||| ||    .|. |....||||..... |  | .|.  |.
lkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
PTPc_DSPc_SM00012 357-405 7.9e-09 31.0 In-house 31-82 (105) alignment 
Range on Protein: 357-405
Range on HMM: 31-82/105.0
E------AvsaGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALRQV
.          .. |.||| |||.|. |.||....| .... ..... .| ....
knknkses...skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkel
subfamily_CDC14_pd Subfamily CDC14 353-412 2.3e-07 25.0 In-house 254-315 (328) alignment 
Range on Protein: 353-412
Range on HMM: 254-315/328.0
QFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALR--QVVSPNLAF
.|.. | .| | . ||| ||. |  |..|.||.  .... . .|..|.  |  .|..|   |
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkf
Rhodanese Rhodanese-like domain 62-172 3.3e-07 22.8 Pfam-A 7-111 (113) alignment 
Range on Protein: 62-172
Range on HMM: 7-111/113.0
SMLeaysPAHATLLLDTRHPSQFARHHIISSINMITAPLmmrrLGQGKVPLSAALRLDANDSAPDLEQITAIVLIGagdAANDQSVFDAVV-----AAVG
..|     .   .|||.| |...|. ||  ..|.    |     .... .    |  . ..|. .|.. . .|. .   .  ..| . | .      .  
ell....ekekvvllDvRspeeyakghIpgAvnvpldsl....yprrdlffkdklaeeleesgkkldkdktvvvyc...rsgnrsggaaalllalilkel

GHVVCYYLQGGFPSFA
|.  .|.| ||| ...
gyknvyvLdGGfeawk
subfamily_PTPDC1_pd Subfamily PTPDC1 354-403 7.5e-07 23.8 In-house 107-155 (182) alignment 
Range on Protein: 354-403
Range on HMM: 107-155/182.0
FIHEAVSAGgRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHLQALR
 .. |.. | .| ||| ||  |   ..|.||.  .... | .|. ... |
vvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskr
subfamily_Laforin_pd Subfamily Laforin 330-399 1.2e-06 21.6 In-house 80-147 (183) alignment 
Range on Protein: 330-399
Range on HMM: 80-147/183.0
LHLPISDTF-SSEFEVLPsflRGAQFIHEAVSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMETSISHL
. ||. |    |  | ||   ..  ..|  .  | .| ||| ||| || ..|  .|    . |.     .|
iwlptedlstesrvenlp...qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl
subfamily_PTEN_pd Subfamily PTEN 331-394 1.7e-06 23.2 In-house 84-146 (184) alignment 
Range on Protein: 331-394
Range on HMM: 84-146/184.0
HLPISDTFSSEFEVLPSFLRGAQFIHEAvSAGGRVLVHCAAGVSRSPTMVAAYLILYHNMSMET
..|..| .. ..|.| .... ..   |. .    | ||| ||  |. ....|||. .. .. ..
vypfdDhnppplelleeivediekwlee.dkknvvvvHCkaGkGRtGvlivayllkslllekae