Gene MbreMKP-Un-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP005_AA protein Get Run
MbreP005_AA_186-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP10_pd Subfamily DSP10 181-330 1.4e-52 171.7 In-house 6-157 (159) alignment
Range on Protein: 181-330
Range on HMM: 6-157/159.0
ERHHRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISR
|   . .  .|.||.|..|.|  |.. ..|.|||.|.|||.||.   .. |  . |..| ..|. .|.... ||.|.|.|.. | .|  ||.|| |||||
eadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisr

SATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
||||.|||||. ..| || ||  |||.|| |.|||.|||.| ..|..|. ..
satvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk

subfamily_DSP6_pd Subfamily DSP6 182-328 7.7e-49 159.2 In-house 7-156 (158) alignment
Range on Protein: 182-328
Range on HMM: 7-156/158.0
RHHRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKY---PEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISR
.......|..|||.||.|.. .|.|.|.||.|.. .|||.|..   |.   .|. | ||.|.| ..|...| | .|.|.|.. | .   ||.|| |||||
kkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisr

SATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAA
| ||..||||  ..| || ||  ||.|.. |.||..||| |  .|..|  
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl

subfamily_DSP1_pd Subfamily DSP1 189-330 3.2e-45 148.1 In-house 17-160 (163) alignment
Range on Protein: 189-330
Range on HMM: 17-160/163.0
PAQ-ILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP-EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
| . ||..||.|.| .| |.|.||.|..|..||.... .  ..  | |... ..|| ..|.|. ||.. |.|.......| ||.|| ||||||.|. .||
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
||. ... |. |.  ||.||..| ||. |...| .||.|| .. 
lmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel

PTPc_motif_SM00404 189-325 7.9e-43 140.7 In-house 2-140 (140) alignment
Range on Protein: 189-325
Range on HMM: 2-140/140.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSR--KYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
| .|||.||.| . .|.|..||| |..|||.|.|.  |   . ..| . || ..|. ....|| .. . ..|......|| || || ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
||. |.|.|..||. ||||||.| ||| |. .|. ||.|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk

subfamily_DSP8_pd Subfamily DSP8 186-329 6.4e-42 136.8 In-house 12-157 (159) alignment
Range on Protein: 186-329
Range on HMM: 12-157/159.0
DKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHD--SRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVA
|  | .||..||.|.. .. ..|||..|....|||. ...  . . .|  .... ..|. . ... .|. ..|.|.|...| |.||.|. ||||||||||
dvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|||.|   |..|. ||  |||.|| | ||| |.| |  ||..|  .
iayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll

subfamily_DSP19_pd Subfamily DSP19 184-326 2.4e-41 135.6 In-house 7-150 (152) alignment
Range on Protein: 184-326
Range on HMM: 7-150/152.0
HRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP-EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATV
..|.  ... |.||.|.   |...| ||. ..||.||..|.  . .| .| | .| | |  ..|... ...|...|.. | . |.||.|| ||.||||.|
kedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

AIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
.|||||. .||.|. |...|.| |||| ||  |.  |..||..|
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP14_pd Subfamily DSP14 190-333 5.4e-41 134.2 In-house 8-151 (157) alignment
Range on Protein: 190-333
Range on HMM: 8-151/157.0
AQILPYLYVGaEAHAENRELLKRLNVTHVLNLTT-HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLM
.|| |.|...  . | ..||||. ..|...|.|.   ..|.... . .....|. .....| |. . ..|.. ...||..|.|||||.||||....||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
 ...| |. ||..||..|| | ||. |  .|..||.|| .|  ||
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvk

0044763 (Phosphotyrosine protein) phosphatases II 186-333 6.5e-41 135.3 In-house 20-177 (178) alignment
Range on Protein: 186-333
Range on HMM: 20-177/178.0
DKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE----------FGYHQIAIRDSWNQDMSKCFEDAFEYINKCR-AEGGCVLLHCVA
   . .|||.||.|.  .|...||||.|..||..|||. . . ...          . |..| | |. ..|... |....|.|....  .||.|| || |
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsa

GISRSATVAIAYLMTFRELDLNAAYSTVKERRPcIAPNLDFMGELQRYEEKLAAKRQVK
|..||.|...||||  . |.|..|.. |.|||| | || ...  |...|..| ... ..
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesdll

subfamily_DSP15_pd Subfamily DSP15 191-329 2.7e-38 125.4 In-house 4-142 (151) alignment
Range on Protein: 191-329
Range on HMM: 4-142/151.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTF
..|| ||.|    ....||||. |.||.|..     .  ... |. ||. |. ....|| |... |.| ||| ... ||.||.||.|||.|...||||| 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

RELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
 ||. . | ...|..| .  ||. |   |. ||.. ...
telnwrdalevikaaRsvanPnfGfkrqlkeyektklke

subfamily_Slingshot_pd Subfamily Slingshot 188-332 3.6e-37 121.3 In-house 18-163 (169) alignment
Range on Protein: 188-332
Range on HMM: 18-163/169.0
APAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
....|  ..|.|.|  | | | ||. .|...||.|      .|| | |..| . |. ..|. | .......|.|....|  ||.||  |.||||.. |||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQV
 |   .|.|. |.. ||||| .| ||  |.  |. ||  | |..| 
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqr

DSPc Dual specificity phosphatase, catalytic domain 196-324 3.8e-37 122.1 Pfam-A 1-132 (133) alignment
Range on Protein: 196-324
Range on HMM: 1-132/133.0
LYVGAEAHAEnRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFR
||.|.. .|.  .||. |..|.|.|.|.. .    .| .|. | .| ..|......|| .|.| |.|.|....|. || || ||||||||..|||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|.|| ||. |||||..| ||  |...|  ||.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 196-324 3.8e-37 122.1 In-house 1-132 (133) alignment
Range on Protein: 196-324
Range on HMM: 1-132/133.0
LYVGAEAHAEnRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFR
||.|.. .|.  .||. |..|.|.|.|.. .    .| .|. | .| ..|......|| .|.| |.|.|....|. || || ||||||||..|||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|.|| ||. |||||..| ||  |...|  ||.
nlslneAyefvkerrskispnagflrqLleyer

0048179 (Phosphotyrosine protein) phosphatases II 189-326 3.2e-35 116.3 In-house 4-144 (144) alignment
Range on Protein: 189-326
Range on HMM: 4-144/144.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEF---GYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIA
|..|||.||.|   .|.. ||||.|..|.|.|||..    ..|.    |... . |    |... .....|.|.....|||.|| || ||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
|||  . |.|. |.  |..|||.. || ...  |..||..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

0048076 (Phosphotyrosine protein) phosphatases II 189-326 1.1e-34 114.5 In-house 4-142 (145) alignment
Range on Protein: 189-326
Range on HMM: 4-142/145.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLtTHDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
|..|||.||.|   .|...||||.|..|.|||| |.. . . .  . |... . |   .|... .....|.|.....|||.|| || ||..|..|...||
pseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
||  . ..|  |.  |...||.. || ...  |...|..|
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

0043147 (Phosphotyrosine protein) phosphatases II 189-326 3.1e-34 113.6 In-house 19-160 (172) alignment
Range on Protein: 189-326
Range on HMM: 19-160/172.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTH----DSRKYPEFGYHQIAIRDSWNQdMSKCFEDAFEYINK--CRAEGGCVLLHCVAGISRSATV
| ......... . .|.....||.|..||..|||..    .  .   . |. . . | . . ... .....|.|..  .. .||.|| ||.||..|..|.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

AIAYLMTfRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
..||||  . |.|  |...|.|.||.. .| ...  |. .|..|
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0041856 (Phosphotyrosine protein) phosphatases II 184-327 1.5e-33 111.3 In-house 14-173 (182) alignment
Range on Protein: 184-327
Range on HMM: 14-173/182.0
HRDKAPAQILPYLYVGAEAH--------------AENRELLKRLNVTHVLNLTthDSRKYPEF------GYHQIAIRDSWNQDmskcFEDAFEYINKCRA
...  . .|...||.|.  .              |.. ..||.|..|...|||  . . .||.       |... . |    |    .......|.....
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

EGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRP--CIAPNLDFMGELQRYEEKLA
|||.|| || ||..|..|...||||  ....|  |...|..|||  .| ||  |.  |. .|..| 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_DSP12_pd Subfamily DSP12 191-325 2.8e-33 109.5 In-house 4-142 (155) alignment
Range on Protein: 191-325
Range on HMM: 4-142/155.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
.||| ||.|  ..... |||| |..|||| .....      |  .  . .| |.|. ..|. . ...|...|.....|.| || || ||.|||.|. |||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
||   .|.|. |...||| .| | ||  |.  |. .|. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekm

subfamily_DSP3_pd Subfamily DSP3 191-330 3e-33 108.8 In-house 13-161 (162) alignment
Range on Protein: 191-330
Range on HMM: 13-161/162.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTH-------DSRKYP--EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA-EGGCVLLHCVAGISRSA
.. | |||| || |.... ||.| .||||| .         ..  |   |. |. . ..|. . |.|| || |...|..  . . | ||.|||.|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVAIAYLMTFRELDLNAAYSTVKERRpCIAPNLDFMGELQRYEEKLAAKR
|...|||| .|...|. | .||...| .| ||  |.  |. ..|.|. |.
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrkk

PTEN_1 172-329 4.5e-33 109.7 In-house 22-194 (196) alignment
Range on Protein: 172-329
Range on HMM: 22-194/196.0
RNM----------TPSTPIERhhrdkapaQILPYLYVGAEAHA-ENRELLKRLNVTHVLNLTTHDS---RKY-------PEFGYHQIAIRDSWNQDMSKC
. .          .||.|. .        .| . ||.| . .. .... ||  ..|.|.||.  .    | |         . |... |.| . ...|. 
ltyitsriiamgkapsrpllq........eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

FEDAFEYINKCRA--EGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|. . . |. ...  .|..|| || ||..||.||..||||  . |. . | . |.|.||..|||  .. .|..|...| |.
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae

subfamily_LRR-DSP_pd Subfamily LRR-DSP 188-327 8.8e-33 107.5 In-house 119-259 (263) alignment
Range on Protein: 188-327
Range on HMM: 119-259/263.0
APAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQI-AIRDSWNQDMSKCFEDAFEYINKCRAEGGcVLLHCVAGISRSATVAIA
 | .|.. |..|.   | |. .|| |.|||.|   ..    .|. | |  |  |.|  . |.|. ||.   .|.. | .|| ||.|| ||.|||.|. |.
vPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvis

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLA
|||  ..| .. |.  |...|| | ||  |.  |..||.|| 
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf

subfamily_MKPLT_pd Subfamily MKPLT 187-329 1.9e-32 106.0 In-house 19-163 (164) alignment
Range on Protein: 187-329
Range on HMM: 19-163/164.0
KAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAI
  |. .|.  || |   ||.|...|| |..||..|...    ..|. . | |. . |  .. .|. .| | ... .    ||.||.||| | |||..|..
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|.|....   |. ||. .|||| ..|||  |. .| ..|| .  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

subfamily_MKPLV_pd Subfamily MKPLV 187-329 1.9e-32 106.0 In-house 19-163 (164) alignment
Range on Protein: 187-329
Range on HMM: 19-163/164.0
KAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAI
  |. .|.  || |   ||.|...|| |..||..|...    ..|. . | |. . |  .. .|. .| | ... .    ||.||.||| | |||..|..
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|.|....   |. ||. .|||| ..|||  |. .| ..|| .  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

0049260 (Phosphotyrosine protein) phosphatases II 190-326 8.2e-32 105.4 In-house 9-149 (152) alignment
Range on Protein: 190-326
Range on HMM: 9-149/152.0
AQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP----EFGYHQIAIRDSWNQDMSKCFEDAFEYINK-CRAEGGCVLLHCVAGISRSATVAI
 ........| . .|.. ..||.|..|....||... ....     . |... . |.. .|.| ....... |.| .. .||.|| ||.||..|..|...
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYLMTfRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
||||  . ..|  |.. |.|.||.. || ...  |. .|..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

0046846 (Phosphotyrosine protein) phosphatases II 182-326 1.2e-31 105.2 In-house 5-172 (176) alignment
Range on Protein: 182-326
Range on HMM: 5-172/176.0
RHHRDKAPAQILPYLYVGAEA----------HAENRELLKRLNVTHVLNLTTH------------DSRKYPEFGYHQIAIRDSWNQDMsKCFEDAFEYIN
... |  . .|...|..|.            .|.. |.||.|..|.|.|||..            .  . ... |... ..| .  |. . .....|.|.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

KCRAEGGCVLLHCVAGISRSATVAIAYLMTF-RELDLNAAYSTVKERRP-CIAPNLDFMGELQRYEEKL
... |||.|| ||.|||.|..|...|||.   . |... |...|.|.|| .. .. ...  |...| .|
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

0049772 (Phosphotyrosine protein) phosphatases II 149-331 6.3e-30 100.4 In-house 148-278 (314) alignment
Range on Protein: 149-331
Range on HMM: 148-278/314.0
FCEANPNNtppqaalslsslsldrnmtpstpierhhrdkapaqilpylyvgAEAHAENRELLKrlnvthvlNLTTHDSRKYPE-FGYHQIAIRDsWNQDM
.... .|.                                           .| .|.. ||||        . .. ...   . . |..| . | .... 
llildgng...........................................neptaadlellk........eelydpelferlgikylripvpD.gsapl

SKCFEDAFEYINKCrAEGGCVLLHCVAGISRSAT-VAIAYLMTFRELDLNAAYSTVKERRPcIAPNLDFMGELQRYEEKLAAKRQ
.. |....|.|...  .||.|| || ||..|..| |..||||  . ..|. |.. |...|| | ||  |.  |..||..| |...
ledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealle

0045098 (Phosphotyrosine protein) phosphatases II 179-327 1.5e-29 98.7 In-house 12-272 (278) alignment
Range on Protein: 179-327
Range on HMM: 12-272/278.0
PIERHHRDKAPAQILPYLYVGAEA-----------------------------------------HAENRELLKRLNVTHVLNLTTH-------------
  |. ..   | .|.|.||.|  .                                         .| . ..|. |..|....||.              
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

--------------------------------------DS--RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA--------------EGGCVLL
                                      |   |.   . |. .   .. .....| | ...|.|.....              .||.|| 
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCVAGISRSATVAIAYLMTFR---ELDLNAAYSTVKERRPC-IAPNLDFMGELQRYEEKLA
|| ||..|..|...||||  .    .||  |.......||. . .||...  | ... .| 
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 189-324 2.2e-29 95.9 In-house 7-145 (148) alignment
Range on Protein: 189-324
Range on HMM: 7-145/148.0
PAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEFG--YHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIA
|..| . .|..|.  .| . | || |.||.. | |      . . |  | ..|..|  ..|.|. |||. ....| ..||. ||.|.  |.|||. .|..
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|. |..  |. |.  ||..|. . ||| |.  |. .|.
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

0036282 (Phosphotyrosine protein) phosphatases II 191-325 1.2e-27 92.1 In-house 14-168 (174) alignment
Range on Protein: 191-325
Range on HMM: 14-168/174.0
QILPYLYVGAEAHAeNRELLKRLNVTHVLNLTTHDSR----------------KYPEFGYHQIAIRDSWNQDMSKcFEDAFEYINKCRAE--GGCVLLHC
 |.|.|..|.  .| . |.||.|..|.|..|..   .                .   . |... . |    |.|. .............|  ||.|| ||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

VAGISRSATVAIAYLMTFREL-DLNAAYSTVKERR---PCIAPNLDFMGELQRYEEK
 ||..|..|...||||  . | .|  |...|.|.|   |.. .. ...  |. .| .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

0037934 (Phosphotyrosine protein) phosphatases II 171-324 5.1e-27 90.4 In-house 12-239 (243) alignment
Range on Protein: 171-324
Range on HMM: 12-239/243.0
DRNMTPSTPIERHHRDK---------APAQILPYLYVGAE--------AHAENRELLKRLNVTHVLNLTTH-----------------------------
..|  .. .   | | |            ...|.|...          ..|.. ..|..|..|....||.                              
sknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllsee

-----------------DSRKYPEFGYHQIAIRD----SWNQDMSKCFEDAFEYINK-----CRAEGGCVLLHCVAGISRSATVAIAYLMTFR-ELDLNA
                 |  ..  . ||.... |    .  .|. . .... |.|..     .. .|| ||.||.||..|..|...||||  . ..||  
hlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdlee

AYSTVKERRPC-IAPNLDFMGELQRYEE
|. ...|.||. . ......  |.... 
avkllreqRpgkavqtpsqyrflyeall

0040439 (Phosphotyrosine protein) phosphatases II 193-325 1.3e-26 89.1 In-house 33-244 (249) alignment
Range on Protein: 193-325
Range on HMM: 33-244/249.0
LPYLYVG------------------------AEAHAENRELLKRLNVTHVLNLTTHDS------------------------------------------
|| |. .                         |. . ....|..|..|....||. .                                           
lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlelt

--RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA------EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNL
   . ... ...| . |   .. .. |||....|...|       .||.|| || ||..|..|...||||     . ...||  |.......||.. .|.
nlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

DFMGELQRYEEK
...  |.... .
eqyrflyealle

0042113 (Phosphotyrosine protein) phosphatases II 172-323 1.5e-26 88.8 In-house 12-239 (245) alignment
Range on Protein: 172-323
Range on HMM: 12-239/245.0
RNMTPSTPIERHHRDKAP------------------AQILPYLYVGAEAHAENRE----LLKRLNVTHVLNLTT--------------------------
.|  .. ..  | | | .                   .| | .....  ..|. |    .|..|..|....||.                          
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftv

---------------------HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA--EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDL
                      |. .   . ||.. . |    |... ..|..|...|..|  ..| || || ||..|..|...||||     . ....|
tllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsl

NAAYSTVKERRPCIAPNLDFMGELQRYE
  |.  ....||.. ......  |....
eeavkelrsqRpgavqtpsqyrflyeal

0051082 (Phosphotyrosine protein) phosphatases II 191-319 2.6e-25 84.2 In-house 10-146 (151) alignment
Range on Protein: 191-319
Range on HMM: 10-146/151.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHD-----SRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE-GGCVLLHCVAGISRSATV
.. ..||...  .|.. ||||.|......||.. .      . .||  . ...| | | ...... .|. . |.......  .|.|| || ||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

AIAYLMTfRELDLNAAYSTVKERRP-CIAPNLDFMGEL
...|||  . ..|..|.. ....|| .. ||  |. .|
valylml.lgvsleealeeyrlkrpgvvqpnqqflfql

subfamily_STYXL1_pd Subfamily STYXL1 186-327 4.3e-25 81.8 In-house 8-154 (157) alignment
Range on Protein: 186-327
Range on HMM: 8-154/157.0
DKAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKY---PE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSA
 . | ..||  ||.| . .| |... | | |  ..|...   . .   ..     .||. |. . |. . ...| ..|.| . || .||.    ||||||
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

TVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLA
.|.|||||  ... |. ||. .|. .. . || .|.  |...|..| 
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll

0045450 (Phosphotyrosine protein) phosphatases II 208-325 4.6e-24 81.1 In-house 125-302 (307) alignment
Range on Protein: 208-325
Range on HMM: 125-302/307.0
ELLKRLNVTHVLNLTTHDSR-----------------------------KYPEFGYHQIAIRDS-----------------WNQDMSKCFEDAFEYINKC
..|....||....||. . .                             ..... .... . |.                  ... .. ||.... |...
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RA------EGGCVLLHCVAGISRSATVAIAYLMTFRE--------LDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
|.      .||.|| || ||..|..|...||||  .         .||  |.....|.||.. .|....  |.... .
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 194-326 6.2e-24 78.1 In-house 8-152 (154) alignment
Range on Protein: 194-326
Range on HMM: 8-152/154.0
PYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE----------FGYHQIAIRDSWNQDMSKCFEDAFEYINKCR--AEGGCVLLHCVAGISRSAT
 .||...   | |. .|.  |....||  .  .  ...          . | .. . |  |.|. . .. |||.|..     | . ||.|. .|.||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
..|.|||  ... |  |.  .|. |. | ||  |.  |...| .|
llisylmdklkislslalellkdsryiikPnqGflkqleifekel

0039614 (Phosphotyrosine protein) phosphatases II 207-326 1.9e-23 78.8 In-house 118-288 (297) alignment
Range on Protein: 207-326
Range on HMM: 118-288/297.0
RELLKRLNVTHVLNLTTHDSRKY--------------------P-----------------------EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA
 .......||....||. . ..                                                .. . . |    . .. . ...|......|
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
   .||.|| ||.||..|..|...||||     . ...|.  |.....|.||.. ......  |.... .|
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

0040438 (Phosphotyrosine protein) phosphatases II 208-330 3e-22 74.7 In-house 104-279 (317) alignment
Range on Protein: 208-330
Range on HMM: 104-279/317.0
ELLKRLNVTHVLNLTTHDSR----------------------------KYPEFGYHQIAIRDS----------------WNQDMSKCFEDAFEYINKCRA
.......||....||. . .                            ..... .... . |.                  ..  . ... .. ....|.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

E----GGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
     ||.|| ||.||..|..|...||||     . ...|.  |. ...|.||.. ......  | ... ..  ..
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 196-328 3.2e-22 72.2 In-house 6-143 (145) alignment
Range on Protein: 196-328
Range on HMM: 6-143/145.0
LYVGAEAHAENRELLKRLNVTHVLNLTTHDS-----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTF
||||.  ||..  .|. | .. ..|... ..      |  ..    |.  |    |.|. |..  ..|.| . ||  |..||.||.||| ||..|.|| .
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAA
 .. |  |   |. .|    ||. |. .| . | .|  
cnmtlseaarqvrsnrllaypnvtflknllnlekqlke

0051429 (Phosphotyrosine protein) phosphatases II 196-327 5.8e-22 74.1 In-house 24-225 (272) alignment
Range on Protein: 196-327
Range on HMM: 24-225/272.0
LYVGAEA---HAENRELLKRLNVTHVLNLTTHD-------SRKYPEFGYHQIAIRDSWNQDMS-------------------------------------
|| ..      |.. . ||.|.......|.. .       .|  | . |... | |.  ....                                     
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevm

--------------KCFEDAFEYINKcraeGGCVLLHCVAGISRSATVAIAYLMTfRELD--------------LNAAYSTVKERRPCIAPNLDFMGELQ
              . . ...|....    || || || ||..|..||. ..|.  . ..              | .|.. ....||.. .. ...  |.
hlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

RYEEKLA
... .|.
eallell

subfamily_STYX_pd Subfamily STYX 190-333 1.4e-21 70.3 In-house 13-164 (166) alignment
Range on Protein: 190-333
Range on HMM: 13-164/166.0
AQILPYLYVGAEAHAENR--ELLKRLNVTHVLNLTTHDSRK-----Y-PEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSAT
 .||| |..|  . | .   | ||.  .||.. .      .     .  .| |  . . |.  ... . .    |.|...  .|| ||.|  |||||||.
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

VAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
. |||.|    |    |.  |.||| ||.||  |. .|. ||    || ..|
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltik

0036941 (Phosphotyrosine protein) phosphatases II 190-333 9.2e-21 69.8 In-house 20-283 (297) alignment
Range on Protein: 190-333
Range on HMM: 20-283/297.0
AQILPYLYVGAEAHAENRELLK----------------------------------------------------------RLNVTHVLNLTTHDSR----
 ..||.|. |   .|.. | |.                                                           .|||....||. ...    
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

--------------------------------------------KYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA------EGGCVLLHCVAGIS
                                            . ...  ... . .    ..  .... ...|...|       .|| || ||.||..
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSATVAIAYLM--------TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
||.|...|.||        . ...|.  |. ...|.||.. ..|...  | ... .|  |. .|
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk

0038934 (Phosphotyrosine protein) phosphatases II 212-326 1.7e-19 65.7 In-house 54-176 (194) alignment
Range on Protein: 212-326
Range on HMM: 54-176/194.0
RLNVTHVLNLT----THDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE--GGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVK
  ....|..||    . | .....  . |... . | ..    .   . .. ...  .|  ||.|. ||.||..|..|...|||.  . .....|. ...
nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

ERRPCIAPNLDFMGELQRYEEKL
|.|| . || |.. .|... . |
ekRpgaipnqdyleallkrykel

0043336 (Phosphotyrosine protein) phosphatases II 207-323 1.5e-18 62.7 In-house 105-273 (278) alignment
Range on Protein: 207-323
Range on HMM: 105-273/278.0
RELLKRLNVTHVLNLTTHDSRK----------------------------------------------YPEFGYHQIAIRDSWNQ-DMSKCFEDAFEYIN
..... |.||....||. . ..                                              .   .|| ... |     ..|  ..   . ..
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

KCRAEGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYE
... ..|.|| ||.||..|..|....||.     . ...||  |.....|.||.. ......  | ...
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

subfamily_PTPMT1_pd Subfamily PTPMT1 216-328 2.2e-18 61.3 In-house 48-170 (171) alignment
Range on Protein: 216-328
Range on HMM: 48-170/171.0
T--------HVLNLTTHDSRKYPEFGYHQ--IAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKER
         . |.. .  .... . | .|  .|. |  ..   .  |.. |.|.| . .| .| .|| || .||||....|||. ..|... | ...|..
kavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkk

RPCIAPNLDFMGELQRYEEKLAA
|. |  .   .  ||.||||| .
Rkiirlakkqwkalqeyeeklls

subfamily_MSG5_pd Subfamily MSG5 169-329 2.7e-15 49.9 In-house 5-163 (165) alignment
Range on Protein: 169-329
Range on HMM: 5-163/165.0
SLDRNMTPSTPIE-RHHRDKAPAQILP-YLYVGAEAHAEnrELLKRLNVTHVLNLTTHDSRKYPEFGYHQIaiRDSWNQDMSKCFEDAFEYINKCRAEGG
..|... ..  .. |.   . |  .||  ||. .| . .  |||    |  | .  ..   . |   |. |  .   .  . | .    . |   .... 
nedielvhaeildvrrvyldgpllvlpeklylysepklk..ellsfdlvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrk

CVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
 .|.||  |.||||.. .||.| . .| |. ||  .| .   |.|.. .. .|  .|  |..|
kilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk

0047943 (Phosphotyrosine protein) phosphatases II 215-316 2.4e-14 48.9 In-house 102-261 (273) alignment
Range on Protein: 215-316
Range on HMM: 102-261/273.0
VTHVLNLTTHDSRK----------------------------------------------YP-EFG---YHQIAIRDSWNQDMSKCFEDAFEYINKCRA-
|...  ||. ....                                              .. ..    .|   . |    .  . . . .|...|... 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFM
  ..| |. ||.||..|..|.....|.     . ...|.  |.  ....||.. ......
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy

0051299 (Phosphotyrosine protein) phosphatases II 217-314 1.7e-12 42.9 In-house 119-273 (288) alignment
Range on Protein: 217-314
Range on HMM: 119-273/288.0
HVLNLTT---------------------------------------------------HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKC-RAE
..  ||.                                                    |. ..    .| ... |    |  . . |  ....|. .. 
vIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasg

GGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLD
||.|. || ||..|..|.....|.     . ...|.  |. ...|.||.. ....
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

Rhodanese Rhodanese-like domain 21-144 4.5e-12 38.5 Pfam-A 2-111 (113) alignment
Range on Protein: 21-144
Range on HMM: 2-111/113.0
PEELMGLMetDTDRLVVLDVRPYSDYVVGHIKNAFTLRFSSIllrrlrqNKVSVLDLLIDEASQCIFRERTSRPHAVIVVYDnntteldISEPDHRNSLH
..||  |.  . ...|.||||. ..|  |||..|  ....|.       .. . |    ..|...  ...   ..  .|||.        |  . ..  .
akelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.......yprrdlffkdklaeeleesgkkldkdktvvvyc.......rsgnrsggaaa

VTVQHLLNS-NY-HVRFLRGGFNGFQ
. ....|..  |  |..|.|||....
lllalilkelgyknvyvLdGGfeawk

0050432 (Phosphotyrosine protein) phosphatases II 214-314 6.5e-12 40.9 In-house 132-286 (308) alignment
Range on Protein: 214-314
Range on HMM: 132-286/308.0
NVTHVLNLTTHDSR---------------KYPEFGYHQ-----------------------------------IAIRDSWNQDMSKCFEDAFEYINKCRa
||...  ||. . .               .. |.|. .                                   ..  |    .  . . | .|...|.. 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLD
.|| .. || ||..|..|.....|.     . ...|.  |. ...|.||.  ....
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 219-314 6.5e-12 40.9 In-house 153-261 (284) alignment
Range on Protein: 219-314
Range on HMM: 153-261/284.0
LNLTTH--DSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE---GGCVLLHCVAGISRSATVAIAYLMTFR--------ELDLNAAYSTVKER
| || .  ..  .    .| ... |    . .. . . ........ .   || .. || ||..|..|.....|.  .        ..|.  |.. ..|.
leltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq

RPCIAPNLD
||.   .|.
Rpgmvqtle

subfamily_RNGTT_pd Subfamily RNGTT 231-327 2.3e-07 24.7 In-house 77-176 (189) alignment
Range on Protein: 231-327
Range on HMM: 77-176/189.0
EFGYHQIAIR---DSWNQDMSKCFEDAFEYINKcRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGEL-QRYEEKL
.  |......   .. ...  | |    |  .| .     . .||  |  |.  ....||.  .. ...|| .. .. ||    . |.. || .||..  
gikyvklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadve

A
.
e

subfamily_DSP23_pd Subfamily DSP23 208-308 7.1e-07 24.0 In-house 25-127 (148) alignment
Range on Protein: 208-308
Range on HMM: 25-127/148.0
ELLKRLNVTHVLNLTTH---DSRKYPEFGYHQIAIRDSWNQDMsKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKE
. |  | | ... ||..   ..   |.  .... | |     . .  ..  . ...  . .  | .||. |  |. |.   ||.  |.|    | . |..
rylldlgvrylvslteegrphveatpnltlvrlriddyhppal.eqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

RRPC
.|| 
lrpg

0048567 (Phosphotyrosine protein) phosphatases II 254-316 4.1e-06 21.3 In-house 63-128 (157) alignment
Range on Protein: 254-316
Range on HMM: 63-128/157.0
AFEYINKCRAEGGCVLLHCVAGI---SRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFM
. .... .. .|. . .|| ||    .|.||.. .||.    .. . |.  ..  || . |  | .
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdas

PTPc_DSPc_SM00012 251-288 8.1e-06 21.4 In-house 22-62 (105) alignment
Range on Protein: 251-288
Range on HMM: 22-62/105.0
FEDAFEYINKCRAE---GGCVLLHCVAGISRSATVAIAYLM
. .......|.. .   .. |..|| ||..|..|.. ....
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldil