Gene MbreMKP-Un-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP008_AA protein Get Run
MbreP008_AA_64-209 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 61-206 6e-74 240.5 In-house 1-147 (148) alignment 
Range on Protein: 61-206
Range on HMM: 1-147/148.0
PSLRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRS
..||||||||..||||||.|..|.|.......|.|.|||..||..||...|||.|..|...| .|..||..||.|.......|..|.|.|||..||||||
aaLrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrs

TACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRE
.|..|..||..||.||.||.||||.||..|.||.|||||||..||.|
salallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqae
subfamily_DSP1_pd Subfamily DSP1 65-207 1.3e-39 129.9 In-house 14-157 (163) alignment 
Range on Protein: 65-207
Range on HMM: 14-157/163.0
TF-PSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADrGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTAC
.. |.|.   ||.|| ...| . ......|.|.|.|.||| .|.| |   .| .. . |..   .|. ||..    ||||...|. |.|| .|.|||.. 
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQREL
.||||..||| || ||  .||..|. ..|| || .|| ..|...|
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP14_pd Subfamily DSP14 74-209 3.5e-35 115.3 In-house 13-147 (157) alignment 
Range on Protein: 74-209
Range on HMM: 13-147/157.0
FLFLGnKHHALDWSVVHDMGLTHIVNCSKEHPNaFADRGIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR
 |||.    ||. ....  ..|.|.|.. | ||    ..|.. .|.|.|..   |.  |...  . .|||..||..||||..||||| . .||||.....
sLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

KSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
.|||||  |||..|  .||| || ||| |.|..  |.
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
subfamily_MKPLT_pd Subfamily MKPLT 63-209 4.2e-35 114.7 In-house 17-163 (164) alignment 
Range on Protein: 63-209
Range on HMM: 17-163/164.0
LRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFAdRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
....|| . .  |.||| .|| .  |..|. .||||| |.|. .||. . . | .|.| ||    ||  .| .     .    ||| ||||..|.|||..
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsss

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
. .|.||. |.  |.||   .|..|  |.|| ||||||| .|.  || 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 63-209 4.2e-35 114.7 In-house 17-163 (164) alignment 
Range on Protein: 63-209
Range on HMM: 17-163/164.0
LRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFAdRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
....|| . .  |.||| .|| .  |..|. .||||| |.|. .||. . . | .|.| ||    ||  .| .     .    ||| ||||..|.|||..
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsss

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
. .|.||. |.  |.||   .|..|  |.|| ||||||| .|.  || 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
0044763 (Phosphotyrosine protein) phosphatases II 59-205 5.5e-33 109.5 In-house 15-169 (178) alignment 
Range on Protein: 59-205
Range on HMM: 15-169/178.0
IGPSLRTFPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKE--------HPNAFADRGIRYFNVRVADEKFAL-SCPFETIPTSTDEVK-AQGGRC
.  |  . .|||.|  |.||.  .| |.  ....|.|||||...|        .| .. . ||.|... . | .    .  |. .    .|.   .||..
lersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpv

LVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQR
||||..||.||...|.|||... . || || .||. .|  . || |.|.|| ..|.|
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
PTPc_motif_SM00404 67-204 4.9e-32 105.7 In-house 2-139 (140) alignment 
Range on Protein: 67-204
Range on HMM: 2-139/140.0
PSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLA
||.| |  |.||.| .| .  .   .|.||..|...| ..  .. |...... . | || .||  .. . .  ......||..||||..||||| . ..|
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
||.|..  ||.||  .||..|. ..|| .|..|| ..|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP10_pd Subfamily DSP10 68-205 1.7e-31 103.3 In-house 15-152 (159) alignment 
Range on Protein: 68-205
Range on HMM: 15-152/159.0
SEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAY
|.. | |||||... | | .... ...|...|  .. || |.. ...|  . | |  |  |.  ||      .|.. .| | ||||  |.|||.. |.||
sqvlp.fLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
|.. .. ||..|  .||.||  . || .|. || ..|..
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP3_pd Subfamily DSP3 68-205 2.1e-31 102.7 In-house 12-156 (162) alignment 
Range on Protein: 68-205
Range on HMM: 12-156/162.0
SEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKE-------HPNAFADRGIRYFNVRVADE-KFALSCPFETIPTSTDEV-KAQGGRCLVHCTMGVSR
 |..|  |..|... | | | .. .|.||..|...        ... . | .|.|. . | |  .| ||  |||     ||  . . |. ||||..||||
devypk.lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

STACVLAYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQR
|...|||||. ... .| ||   |..||. ..||.|||||||. ...
satlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldee
subfamily_DSP6_pd Subfamily DSP6 64-205 2.5e-31 102.3 In-house 11-153 (158) alignment 
Range on Protein: 64-205
Range on HMM: 11-153/158.0
RTFPSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRG-IRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
..|| || | .|.||....| .  |...... ...|  .. ||.|.. | ..| .. . |.    |.  |    .  || . .   .||||  |.||| .
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
 .||||....  || .| .|||...  . ||  |..|| |.|..
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_Slingshot_pd Subfamily Slingshot 67-203 6.7e-31 101.0 In-house 19-154 (169) alignment 
Range on Protein: 67-203
Range on HMM: 19-154/169.0
PSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLA
.|.|.  ...||    | ..  ....| ..|.| .||  | |... ..|.|.|| ||.   |   ...  .  ...|..| ..|||| ||||||.. |.|
askifd.hvylGsewnasnleelkengveyilnvtkeidnffpek.feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
| ... . || || . ||..|. ..||.||||||  .|
yamkeyglsleealeyvkerrsvikPnkgflkqleeye
DSPc Dual specificity phosphatase, catalytic domain 75-204 1.5e-30 100.8 Pfam-A 1-132 (133) alignment 
Range on Protein: 75-204
Range on HMM: 1-132/133.0
LFLGNKHHALdWSVVHDMGLTHIVNCSKEHPN--AFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||.| .|   ..  ..|.|...|..|| ||  |...  |.|... | | .. ..|  .| . .  ......|...||||..|.||| . ..|||..||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. ||.|| ..||..|. ..|| |||.|| ..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 75-204 1.5e-30 100.8 In-house 1-132 (133) alignment 
Range on Protein: 75-204
Range on HMM: 1-132/133.0
LFLGNKHHALdWSVVHDMGLTHIVNCSKEHPN--AFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||.| .|   ..  ..|.|...|..|| ||  |...  |.|... | | .. ..|  .| . .  ......|...||||..|.||| . ..|||..||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. ||.|| ..||..|. ..|| |||.|| ..|.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP19_pd Subfamily DSP19 74-205 3.2e-29 96.2 In-house 18-149 (152) alignment 
Range on Protein: 74-205
Range on HMM: 18-149/152.0
FLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR
 |.|| .  | | . ..  ..|||.| . . ||.|..  . | .. . |..   |.  ....    .|.. . |. ||||  |||||.. |.|||.....
rlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd.ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkee

KSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
.||.||  ||...|. ..||.||.||| ..|..
lsleealelvrearpcikPneGFikqLkeyeae
0048076 (Phosphotyrosine protein) phosphatases II 66-205 1.8e-28 94.4 In-house 3-141 (145) alignment 
Range on Protein: 66-205
Range on HMM: 3-141/145.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFaDRGIRYFNVRVADEKFALS-CPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVL
.||||.|  |.||. ..|||.   .|.|.|...|.. | .. . . ||.|... . |     .   ....    .|. ..||..||||..||.|... |.
wpseilpg.lylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
|||..... || || .||. .| |. || |.|..| ..|..
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0041856 (Phosphotyrosine protein) phosphatases II 63-207 2.5e-28 94.3 In-house 17-173 (182) alignment 
Range on Protein: 63-207
Range on HMM: 17-173/182.0
LrtFPSEIWPAfLFLGNKHH--------------ALDWSVVHDMGLTHIVNCSKEH--PNAFADRGIRYFNVRVADEKFALscpFETIPTSTDEVKAQGG
.  ....|..  |.||. ..              | ..  ....| |.|||.. |.  |. . . ||.|... . |        ....    .||...||
r..dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevleegg

RCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ--GVRPNHGFLKQLADWEQREL
..||||..||.|. . |.|||..... ||.|| .||. .|    ..||..|. ||| .| ..|
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0048179 (Phosphotyrosine protein) phosphatases II 66-204 5.7e-28 92.8 In-house 3-142 (144) alignment 
Range on Protein: 66-204
Range on HMM: 3-142/144.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADR-GIRYFNVRVADEKFALS-CPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACV
.||||.|  |.||.  .|||.   ...|.|...|.. |....|  | ||.|... . |     .   ....    .|. ..||..||||..||.|... |
npseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

LAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
.|||..... || || |||. .| |. || |.|..| ..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0043147 (Phosphotyrosine protein) phosphatases II 73-205 2.4e-27 91.2 In-house 24-159 (172) alignment 
Range on Protein: 73-205
Range on HMM: 24-159/172.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKE--HPNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDE--VKAQGGRCLVHCTMGVSRSTACVLAYLI
|...... ..| .|  ....| |||||. ..   |  . . ||.|  . . |    |.  .. .    ||  .. .||..||||..||.|. . |.|||.
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

RtKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
. .. || || |||..|| |. .| .....| ..|..
l.lglsleeavalvrekRpgavqnpsqyrflyyfekl
0049772 (Phosphotyrosine protein) phosphatases II 70-206 2.8e-27 91.7 In-house 155-273 (314) alignment 
Range on Protein: 70-206
Range on HMM: 155-273/314.0
IwpaflflgNKHHALDWSVVHdmglthivncsKEH--PNAFADRGIRYFNVRVADEKFAlscPFETIPTSTDEVKA--QGGRCLVHCTMGVSRST-ACVL
         |  .| |.   .           .|.  |. | ..||.|... | |. .    ..| ..   . ...  .||. ||||..|..|.. ..|.
g........neptaadlellk...........eelydpelferlgikylripvpDgsap...lledfdeflefieeadkggpvlvHCkaGkgRtgtfvva

AYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQRE
|||..  . ||.|| . |. ||  ..||.||..|| ..|...
aylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_STYXL1_pd Subfamily STYXL1 62-208 1.2e-25 83.6 In-house 6-155 (157) alignment 
Range on Protein: 62-208
Range on HMM: 6-155/157.0
SLRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAF-ADRG-IRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSR
.|.|.|.|. | .|.||| ..| . .. .|. .   || |..  . . .. .  . ....| ||. | |   .. .    .. | .|   ||  . |.||
elktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisr

STACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELG
|.| ..|||.  |. .|..| . .|. .. |.||..|..|| .||.. ||
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
subfamily_DSP12_pd Subfamily DSP12 75-205 9.2e-25 81.8 In-house 9-142 (155) alignment 
Range on Protein: 75-205
Range on HMM: 9-142/155.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEH-PNAFADRGI-RYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||. ... . .  .....||..   ||. |.  ...|  .. .. ..||  . .   .... .  .|  ...|  ||||..||||| . |.|||....
lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkke

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
. || .|  |||.|.. ..||.|||.||  .|. 
klslekAlklvkekkpeiepNegFleQLklfekm
0045098 (Phosphotyrosine protein) phosphatases II 66-207 3.8e-24 81.0 In-house 20-272 (278) alignment 
Range on Protein: 66-207
Range on HMM: 20-272/278.0
FPSEIWPAFLFLGNKH-----------------------------------------HALDWSVVHDMGLTHIVNCSKEHP-------------------
..   .  .|.|||..                                         .| .|  ....| |.||.. ....                   
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------NAFADRGIRYFNV-RVADEKFALSC---PFETIPTSTDEVKA--------------QGGRCLVHCTMGVSR
                             . .  ||.....   . |     .    .|  .    .|. .              .||..|||| .||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

STACVLAYLIRTK---RKSLREAAALVKDKRQG-VRPNHGFLKQLADWEQREL
. . |.|||...    . .| || . .. .| | . .| .....| ..... |
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_DSP8_pd Subfamily DSP8 68-204 5.1e-24 78.6 In-house 16-152 (159) alignment 
Range on Protein: 68-204
Range on HMM: 16-152/159.0
SEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAY
 .| . .|.|| ....|. ......|.....| |.. |.    .  ... | | |.    |.  |..     | .|.. ||.|||.  | |||.. ..||
trilk.nlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
...| . || ||   ||.||. . ||  ||.|| ..|.
imktlemsldeayrfvkekrptispnlnflgqLleyek
0046846 (Phosphotyrosine protein) phosphatases II 68-205 1e-23 79.4 In-house 13-171 (176) alignment 
Range on Protein: 68-205
Range on HMM: 13-171/176.0
SEIWpAFLFLGNKH----------HALDWSVVHDMGLTHIVNCSKEH----------PNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQGGR
..|. | |.||..           .| ..  ....| |..||. .|.          .. . . ||.|... . |     .  ....    .|.  .||.
dyin.anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggp

CLVHCTMGVSRSTACVLAYLIRT-KRKSLREAAALVKDKRQ-GVRPNHGFLKQLADWEQR
 |||| .|..|. . |.|||... |  |. || |||...|  |. .. .....| ..|..
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0049260 (Phosphotyrosine protein) phosphatases II 73-204 1.2e-23 78.9 In-house 13-147 (152) alignment 
Range on Protein: 73-204
Range on HMM: 13-147/152.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNA--FADRGIRYFNVRVADEKFALSCPFETIPTSTDEV--KAQGGRCLVHCTMGVSRSTACVLAYLI
|....|. ..| .|  ....| |.||.. ......  . ...|.|... . |     .  .  .    .|   . .||..||||. ||.|. . |.|||.
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

RtKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. .. || || |||. || |. ||.|.|..| ..|.
l.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 66-204 1.3e-23 77.4 In-house 119-256 (263) alignment 
Range on Protein: 66-204
Range on HMM: 119-256/263.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHI----VNCSKEHPNAFadrgiRYFNV---RVADeKFALSCPFETIPTSTDEVKAQGGrCLVHCTMGVSR
 |.|| .  |||| .. | . |...|.|.|||     ..   .|. |     .|. .   . .| .. .|  || . .  .| . .||  ||||  ||||
vPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklf.....kylsiddiedvd.eadisqhfeetnafieeGrkkGG.vlvhcraGvsr

STACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
|.. |..||.. .|  ..||  ||. ||  ..||.||..||  .|.
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0036282 (Phosphotyrosine protein) phosphatases II 70-204 2.9e-22 74.6 In-house 15-167 (174) alignment 
Range on Protein: 70-204
Range on HMM: 15-167/174.0
IWPaFLFLGNKHHAlDWSVVHDMGLTHIVNCSKEHPNA--------------FADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQ--GGRCLVHCT
|.|  |..|.  .| .|  ... |.|..|.. .|...               . . ||.|. . . |     .  ....    .|. ..  || .||||.
itp.rliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCs

MGVSRSTACVLAYLIRTKRK-SLREAAALVKDKR---QGVRPNHGFLKQLADWEQ
.||.|. . |.|||. .  . ||..| .||. .|    |. .. .....| ..|.
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 73-205 4e-22 72.2 In-house 8-151 (154) alignment 
Range on Protein: 73-205
Range on HMM: 8-151/154.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADR--------GIRYFNVRVADEKF-----ALSCPFETIPTSTDEVKAqgGRCLVHCTMGVSRS
 ||...  . ||.   ..   ...|.|..   .|.|.|.         | | |... |.        |.  || |  .   |.   .. |||.  |||||
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggven..nkvlvhsdkGvsrs

TACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
.| ...||.  .. || .|  |.|| |  ..||.||||||  .|..
aallisylmdklkislslalellkdsryiikPnqGflkqleifeke
subfamily_DSP15_pd Subfamily DSP15 75-207 7.4e-22 72.1 In-house 9-140 (151) alignment 
Range on Protein: 75-207
Range on HMM: 9-140/151.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADrgIRYFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRK
|.||| . . |   ...  .|||.. . .  . . |  |.|  ....|  .  ||  |.       . . ... .|||| .|||||.  | |||.     
lylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtel

SLREAAALVKDKRQGVRPNHGFLKQLADWEQREL
. |.|   .| .|.   || || .|| ..|. .|
nwrdalevikaaRsvanPnfGfkrqlkeyektkl
0037934 (Phosphotyrosine protein) phosphatases II 68-203 3.8e-20 67.9 In-house 40-238 (243) alignment 
Range on Protein: 68-203
Range on HMM: 40-238/243.0
SEIWPaFLFLGNK--------HHALDWSVVHDMGLTHIVNCSKEH--------------------------------------------PNAFADRGIRY
....|  |....         ..| .|  ... | |.||.. ..                                             .. .   .|.|
iyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

FNVRVAD----E-KFALSCPFETIPTSTDE-----VKAQGGRCLVHCTMGVSRSTACVLAYLIRTK-RKSLREAAALVKDKRQG-VRPNHGFLKQLADWE
  . . |    .    |   .. . .  .|     .  .||..||||..||.|. . ..|||. .. . .| || .|....| | . .. .....| ...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
PTEN_1 66-200 4.1e-20 67.4 In-house 35-185 (196) alignment 
Range on Protein: 66-200
Range on HMM: 35-185/196.0
FPSE----IWPAFLFLGNKHHA-LDWSVVHDMGLTHIVNCSKEHPN--------AFADRGIRYFNVRVADEK-FALSCPFETIPTSTDEVKA--QGGRCL
.||.     .. .|..|. ...  |.   . .|.|..|| | | ..         | ..|..| .. . |     ||. |. .    . ...  .|. .|
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

VHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLA
|||. |..||   | |||..... . .|| .||..||  ..|| .....| 
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
0045450 (Phosphotyrosine protein) phosphatases II 86-204 5.3e-20 67.8 In-house 124-301 (307) alignment 
Range on Protein: 86-204
Range on HMM: 124-301/307.0
WSVVHDMGLTHIVNCSKEHPNAF---------------------------ADRGIRYFNVRVADE------------------KFALSCPFETIPTSTDE
|  ... | |.||..... ....                            . |. .....| |                    . ..  ||..    .|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VKA------QGGRCLVHCTMGVSRSTACVLAYLIRTKR--------KSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
|..      .||..||||..||.|. . ..|||. . .         .|.|| .|....| |. .| .....| ....
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 82-204 5.8e-20 67.4 In-house 67-243 (249) alignment 
Range on Protein: 82-204
Range on HMM: 67-243/249.0
HALDWSVVHDMGLTHIVNCSKEHPN-----------------------------------------------AFADRGIRYFNVRvadeKFALSCPFETI
 . .|  ... | |.||..... ..                                                .  ..|.|..       . ..  ||..
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp....dhgvppsfedl

PTSTDEVKA------QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
    ..|.       .||..||||..||.|. . ..|||.     .... .| || .|....| |. .| .....| ....
ldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 82-204 2e-19 65.4 In-house 65-240 (245) alignment 
Range on Protein: 82-204
Range on HMM: 65-240/245.0
HALDWSVVHDMGLTHIVNCSKEH---------------------------------------------PNAFADRGIRYFNVRVADEKFAL-SCPFETIP
 .  |  ... |.|.||....|.                                             .. .   .|.|. . . | . .  .  .. . 
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

TSTDEVKA--QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
   ... |  ..|..||||..||.|. . ..|||.     .... || || . ....| |.... .....| ....
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0051082 (Phosphotyrosine protein) phosphatases II 69-202 1e-18 62.8 In-house 10-149 (151) alignment 
Range on Protein: 69-202
Range on HMM: 10-149/151.0
EIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEH-----PNAFADRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQ-GGRCLVHCTMGVSRSTA
 ...  |....  .| ..  ....|...|||. .|.     |. . . ||..... . | ..  |.  |...    ... .. .| .||||..|..|. .
yvtgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

CVLAYLIRtKRKSLREAAALVKDKRQ-GVRPNHGFLKQLADW
 |..||.   . || || . .. ||   |.|| .||.|| ..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0040438 (Phosphotyrosine protein) phosphatases II 86-206 1.4e-18 62.7 In-house 103-275 (317) alignment 
Range on Protein: 86-206
Range on HMM: 103-275/317.0
WSVVHDMGLTHIVNCSKEHPNA--------------------------FADRGIRYFNVRVAD-----------------EKFALSCPFETIPTSTDEVK
|  |.. |.|.||.  .. ..                           . . || .....| |                   . .   ....    ..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

AQ----GGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRE
..    || .||||..||.|. . ..|||.     .... .. || . .. .| |. .. .....| |...  
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_STYX_pd Subfamily STYX 69-205 4.1e-18 59.0 In-house 14-156 (166) alignment 
Range on Protein: 69-205
Range on HMM: 14-156/166.0
EIWPAfLFLGNKHHALD--WSVVHDMGLTHIVNCSKEHPNAFA----DRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
|| |  ||||    |.     |... |.||||   ..   ..     .  .||. . |||.    .   . |. .  |.   .||. |||   |.|||.|
eilpg.lflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
 |.||.. |     ||| | |...|  . ||.|| .|| ..|  
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0039614 (Phosphotyrosine protein) phosphatases II 86-210 1.3e-17 59.6 In-house 118-292 (297) alignment 
Range on Protein: 86-210
Range on HMM: 118-292/297.0
WSVVHDMGLTHIVNCSKEHPNAF--------------------------ADRGIRYFNVRVADEK-----------FALSCP--FETIPTSTDEVKA---
|  |.. | |.||.  |. ..                            ..  .|...|.  .|               ..|  .|..    ..|.    
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGSR
   .||..||||..||.|. . ..|||.     .... .. || . .. .| |.... .....| |...  |  .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0038934 (Phosphotyrosine protein) phosphatases II 92-202 2.1e-17 58.9 In-house 55-172 (194) alignment 
Range on Protein: 92-202
Range on HMM: 55-172/194.0
MGLTHIVNCSKE----HPNAFADRGIRYFNVRVADEKFAlsCPFETIPTSTDEV-----KAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALV
..|..... ...    .|. | ..||.| .  . |  ..   ..|.. .  | |     . .|| ..|||..|..|.   | |||| . . |..|| ||.
vklglvidltnteryYdpeefekagieylklpfpddgtv..PsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialf

KDKRQGVRPNHGFLKQLADW
..||.|. || ..|..|  .
rekRpgaipnqdyleallkr
0051429 (Phosphotyrosine protein) phosphatases II 68-206 3.4e-16 55.2 In-house 17-224 (272) alignment 
Range on Protein: 68-206
Range on HMM: 17-224/272.0
SEIWPAFLFLGNKH---HALDWSVVHDMGLTHIVNCSKEHPNAFAD-----RGIRYFNVRVADEKFALS-------------------------------
....| .|....      | |.   ...|...||.  .|.  .. .      ||||... . |. .                                  
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

------------------CPFETIPTSTDEVKAqGGRCLVHCTMGVSRSTACVLAYLIRtKRKS--------------LREAAALVKDKRQGVRPNHGFL
                   | |.. .  ... . ||..||||. |..|.   |...|.   . |              |.|| . ....| |.... ...
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

KQLADWEQRE
..| ....  
lflyeallel
0036941 (Phosphotyrosine protein) phosphatases II 86-209 5.1e-16 54.3 In-house 95-279 (297) alignment 
Range on Protein: 86-209
Range on HMM: 95-279/297.0
WSVVHDMGLTHIVNCSKEHPNA--------------------------------FADRGIRYFNVRVADEK-------------FALSCP--FETIPTST
|  |.. . |.||. ... ..                                 ..|  .|.. |   ...                ..|  ....    
WrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

DEVKA------QGGRCLVHCTMGVSRSTACVLAYLI--------RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
..|.       .||. |||| .||.|| . ..|.|.        .... .. ||   ....| |. .. .....| ....  | .
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 75-203 3.5e-15 49.4 In-house 6-138 (145) alignment 
Range on Protein: 75-203
Range on HMM: 6-138/145.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFA---DRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRT
|. |   || | ......|.. ||| .  .  |      . |  . .   | | . ||  |. .    |  | .|   .|||  ||||| .  .|.|.. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

KRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
   .| |||  |. .|    ||  |||.| . |
cnmtlseaarqvrsnrllaypnvtflknllnle
0043336 (Phosphotyrosine protein) phosphatases II 86-203 1.5e-14 49.6 In-house 105-273 (278) alignment 
Range on Protein: 86-203
Range on HMM: 105-273/278.0
WSVVHDMGLTHIVNCSKEH--------------------------------------------PNAFADRGIRYFNVRVADEKFA--LSCPFETIPTSTD
|  |.. | |.||.  ..                                              . .   . .|  . . | ..   ||  .. . .  .
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

EVKAQGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
 .. ..|  ||||. ||.|. . ...||.     .... .| || . .. .| |  ..  ....| ...
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_MSG5_pd Subfamily MSG5 97-204 3.6e-14 46.2 In-house 51-158 (165) alignment 
Range on Protein: 97-204
Range on HMM: 51-158/165.0
IVNCSKEHPNA-FADRGIRYFNVRVA-DEKFALSCPfeTIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHG
..| .|| ..  .    ..|. ..   | | ..  .  .. .     .... . ||||  |.|||.. ..||...    |||.|  ..| . . . |. |
vinvakeindlellvpavkyyhiewehdskivkdls..rltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsig

FLKQLADWEQ
.. || .|| 
lifqlmewev
subfamily_PTPMT1_pd Subfamily PTPMT1 90-204 4.8e-12 40.6 In-house 55-166 (171) alignment 
Range on Protein: 90-204
Range on HMM: 55-166/171.0
HDMGLTHIVNCSKEHPNAfadrGIRYFNVRVADekFALSCPFETIPTS---TDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKR
..  |....|...|. .     |. ...... |  |. .  .|..  .    ..|. .| |  |||  | .||.. | .||. ... |. ||   .|.||
eeyelkalansteewkkl....gveqlqlatvD..fteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkR

QGVRPNHGFLKQLADWEQ
. .| ..  .|.|  .|.
kiirlakkqwkalqeyee
0047943 (Phosphotyrosine protein) phosphatases II 86-199 3.7e-10 35.2 In-house 94-264 (273) alignment 
Range on Protein: 86-199
Range on HMM: 94-264/273.0
WSVVHDMGLTHIVNCSKEHPNAFADrGIRYFNVRVAD---------------------------------------------EKFALSCP--FETIPTST
|  |.. . ..||   ... .   .   .|.   . .                                             .    ..|  .| . .  
wrmvweqnvrviVmLtelvelgrek.caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefi

DEVKA------QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQL
..|.       ..|  .|||  ||.|. . ....|.     .... .. || .|....| |. ..  ....|
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 86-193 2e-08 29.4 In-house 125-285 (308) alignment 
Range on Protein: 86-193
Range on HMM: 125-285/308.0
WSVVHDMGLTHIVNCSKEHPNA-------------------------------FADRGIRYFNVRV-----------------ADEKFALScpFETIPTS
|  |.. . ..||   |.. |                                ..|  .|.. ..                   | .   |  .| . . 
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..peilldf

TDEVKAQ--GGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNH
 ..|. .  || ..|||  ||.|. . ....|.     .... .. || . .. .| |. .. 
lelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 86-193 2.9e-08 29.0 In-house 109-272 (288) alignment 
Range on Protein: 86-193
Range on HMM: 109-272/288.0
WSVVHDMGLTHIVNCSKEHPNA----------------------------FADRGIRYFNVRVA----DEKF-------------ALSC--PFETIPTST
|  |.. . ..||   |.. .                             ..|  .|.. |.       ...               ..   .| . .  
WrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

DEVK----AQGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNH
 .|.    ..|| ..|||  ||.|. . ....|.     .... .. || . .. .| |. .. 
rlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_DSP23_pd Subfamily DSP23 89-188 2.9e-07 25.2 In-house 27-127 (148) alignment 
Range on Protein: 89-188
Range on HMM: 27-127/148.0
VHDMGLTHIVNCSKE-HPNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ
. |.|. ..|  ..| .|.. |  .. . ..|. | .       . .    .| ....    ||| .|  |. . .  ||.. .. .  || | |. .| 
lldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

G
|
g
0046845 (Phosphotyrosine protein) phosphatases II 89-190 6.8e-07 24.4 In-house 97-257 (284) alignment 
Range on Protein: 89-190
Range on HMM: 97-257/284.0
VHDMGLTHIVNCSKEHPNA-----------------------------FADRGIRYFNVRVAD-EKF-------------ALSCP--FETIPTSTDEVKA
|.. . ..||   ... |                              . |  .| . ..  . ...               ..|  .| . .  ..|. 
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

Q------GGRCLVHCTMGVSRSTACVLAYLIRTK--------RKSLREAAALVKDKRQGVR
.      ||  .|||  ||.|. . ....|. .         . .. || . ....| |  
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv
Rhodanese Rhodanese-like domain 2-49 2.1e-06 20.2 Pfam-A 15-78 (113) alignment 
Range on Protein: 2-49
Range on HMM: 15-78/113.0
LVIDVRRRTAFEQARIQGAVHFDA----------------NQQSPLSVPALSHDFVVVYDDDGA
...|||   .... .|.|||...                 .. . .     ... ||||.  |.
vllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvycrsgn
subfamily_PTPDC1_pd Subfamily PTPDC1 105-201 3.3e-06 21.7 In-house 75-170 (182) alignment 
Range on Protein: 105-201
Range on HMM: 75-170/182.0
PNAFADRGIRYFNVRVADEKF-ALSCPFETIPTStDEVkAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLAD
..|....|| ..|.  .| .  .|   .. .    . .  | |.  |||  |  |    . .||. .|| .  .|  ||..||      .. .. . .
lealmeqgiyvynfgwkDygvasleriLdivkvv.afa.lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvke
subfamily_RNGTT_pd Subfamily RNGTT 148-200 6.4e-06 20.0 In-house 116-168 (189) alignment 
Range on Protein: 148-200
Range on HMM: 116-168/189.0
CLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ-GVRPNHgFLKQLA
  |||| |  |.   . .||. ..  |...| || .  |. |.  .. .||.|.
igvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyked.ylkell
subfamily_Laforin_pd Subfamily Laforin 143-187 8e-06 18.9 In-house 108-152 (183) alignment 
Range on Protein: 143-187
Range on HMM: 108-152/183.0
AQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ
 .| .  |||  || |||| |  .|      ||.     .  || 
ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp
0048567 (Phosphotyrosine protein) phosphatases II 105-192 8.7e-06 20.2 In-house 30-124 (157) alignment 
Range on Protein: 105-192
Range on HMM: 30-124/157.0
PNAF-ADRGIRYFNVRVADEKFALSCPF---ETIPTSTDEVKAQGGRCLVHCTMGV---SRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPN
.  |  |.|. |..    .  . |.. .     .    . .. .|..  |||..|    .|.   . .|||   ... .|| |...  |.|  | 
alyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf