Gene DSP10 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP10
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP010_AA protein Get Run
MbreP010_AA_296-440 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP10_pd Subfamily DSP10 290-442 2.1e-73 239.4 In-house 5-158 (159) alignment 
Range on Protein: 290-442
Range on HMM: 5-158/159.0
QQAARRSMPMSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFAD-SLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGIS
..|.....|.||||..|||||..||..|.||....|||.||.||.|||.|.. .|.|..||. |||.||...|||.|.|||..|...|..||||||||||
teadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGis

RSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAHDRS
|||..||.|||...|..||||...|...|.||||||.|||.|.|.| .|.....
rsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
subfamily_DSP1_pd Subfamily DSP1 291-439 6.3e-50 163.4 In-house 9-158 (163) alignment 
Range on Protein: 291-439
Range on HMM: 9-158/163.0
QAARRSM-PMSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISR
 . ..   |. ..| .|.|||. .||||  |....||||||......|.| | ..|..... |.....|. .|| . |||...|...  ||.||||||||
ldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisR

SAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAH
|..... ||| .....|..|...|   |||||||..|...|..|| || .
sstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_DSP6_pd Subfamily DSP6 288-439 1.4e-48 158.4 In-house 4-156 (158) alignment 
Range on Protein: 288-439
Range on HMM: 4-156/158.0
QCQQAARRSMPMsQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFAD--SLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQA
. .. |....|. ..|..|.|||| ||||| .|....|  .||.|...||.|..  .|.|.|||| |  .||....|  |.|||..|...  .||||| |
dklkkaeaefpv.eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhCla

GISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAH
||||| . .. ||| .... ||||...|   .| ||||. ||| |...| .|  
GisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP19_pd Subfamily DSP19 295-437 2.8e-45 148.4 In-house 8-150 (152) alignment 
Range on Protein: 295-437
Range on HMM: 8-150/152.0
RSMPMSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFV
. . ...|  .|.|||   |..  .|.|..|| |||..|.|||.|.. ..|..|.|||..|... .|.. |..||..|...   |||||.||.||||..|
edlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

IGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKL
|.||| .....|..| ..|   |  |.||  |.  ||||| .|
iaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_Slingshot_pd Subfamily Slingshot 299-443 1e-44 145.9 In-house 19-163 (169) alignment 
Range on Protein: 299-443
Range on HMM: 19-163/169.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYL
 |..  ...|||  .||||  |.|.... |||.| .. | |.....|..| . |..|... .|.. ...||..||..| .|||||. |.||||. || | 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAHDRSS
| | ...|..|..||   ||.| || .|.  |.|||| |   . .
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqr
subfamily_DSP14_pd Subfamily DSP14 297-444 2e-43 142.1 In-house 5-151 (157) alignment 
Range on Protein: 297-444
Range on HMM: 5-151/157.0
MPMSQVLSYLFLGsAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIG
  .||. ..|||. .| |.. ..|....||.|.|.|...||| ...... ..|. |..|......|. . . |...|..| ..|||| ||.||||.... 
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAHDRSSK
|||  ....|..|...|  .|.||.||. |  .| .|| ||  . | |
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvk
PTPc_motif_SM00404 299-435 2.3e-43 142.4 In-house 2-139 (140) alignment 
Range on Protein: 299-435
Range on HMM: 2-139/140.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNT-FADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGY
.|..| .|.|||. .|.|.| | ...||...|.|. |..|    . |. |||. |. ......|.. . .||..|...|..||||||||.||||...| |
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEG
||..|...|..| ..|.. |.|||||| |. .| ||| 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0044763 (Phosphotyrosine protein) phosphatases II 295-438 1.7e-41 137.1 In-house 19-171 (178) alignment 
Range on Protein: 295-438
Range on HMM: 19-171/178.0
RSMPMSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADS---------LQYQQIPILDTSEQNIQNYFEVAFEFINQAK-QEGRNVLVHCQ
. ...|..| .|.|||. .|..|. |.|. ||.|.|.|..... | ..         .||..||| | .....  .|. ..|||..|  ..|..|||||.
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

AGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSiISPNLAFMGELKEYEGKLA
||..||...|. |||......|..| ..|  .|. |.||  ..  |.|.| .| 
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
DSPc Dual specificity phosphatase, catalytic domain 306-434 6.3e-41 134.4 Pfam-A 1-131 (133) alignment 
Range on Protein: 306-434
Range on HMM: 1-131/133.0
LFLGSAVDASnLAALREHRITAILNITTDVPNTF---ADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYER
|.|||. .|| || | .. ||...|.|. |||..     . .| .||. |..|..|....| | |||..|.|.|..|||||||||||||...| |||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
|..||.| ..|.  ||.||||  |...| |||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 306-434 6.3e-41 134.4 In-house 1-131 (133) alignment 
Range on Protein: 306-434
Range on HMM: 1-131/133.0
LFLGSAVDASnLAALREHRITAILNITTDVPNTF---ADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYER
|.|||. .|| || | .. ||...|.|. |||..     . .| .||. |..|..|....| | |||..|.|.|..|||||||||||||...| |||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
|..||.| ..|.  ||.||||  |...| |||
nlslneAyefvkerrskispnagflrqLleye
0048076 (Phosphotyrosine protein) phosphatases II 299-437 2.5e-37 123.1 In-house 4-142 (145) alignment 
Range on Protein: 299-437
Range on HMM: 4-142/145.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYL
.|..| .|.|||  .|..|. |... ||..||.|.. .. ..  .||...|. | ..... .... ..|||..| .||..|||||.||..|....|. ||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKL
|......| .| ..|  .|... ||  ..  |.|.| .|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP8_pd Subfamily DSP8 298-439 3.8e-36 118.1 In-house 14-156 (159) alignment 
Range on Protein: 298-439
Range on HMM: 14-156/159.0
PMSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPN-TFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIG
 . ..| .|.||| .|. .  .|..  |. .||. .  |.  .    .. ..|. |. . .. ..|. ..|||..||.|  .||||. |||||||. .|.
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAH
|.| . .|.|..|...|   |  ||||| |.| | ||| .|  
yimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0048179 (Phosphotyrosine protein) phosphatases II 299-437 7e-36 118.4 In-house 4-144 (144) alignment 
Range on Protein: 299-437
Range on HMM: 4-144/144.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSL--QYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIG
.|..|..|.|||  .|..|. |... ||...|.|.. ...|      ||...|. | .  .. .... ..|||..| .||..|||||.||..|....|. 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKL
|||......|..| ..|  .|... ||  ..  |.||| .|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP12_pd Subfamily DSP12 299-436 7.5e-36 117.9 In-house 2-142 (155) alignment 
Range on Protein: 299-436
Range on HMM: 2-142/155.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTD-VPNT--FADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVI
.|..|  |.||.. .. . . |.|  ||..| ...  .|.    .  .....|.|||. |..| .... |..||..| .|...||||||||.|||...||
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

GYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGK
 |||.. ...|..|.. |.  .. |.||  |.  || .|  
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_DSP15_pd Subfamily DSP15 299-440 7.6e-36 117.5 In-house 2-142 (151) alignment 
Range on Protein: 299-440
Range on HMM: 2-142/151.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITtDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYL
.|.||  |.||   |... . |.|..|| ||..  | .. . . ..|. |.. ||........|. . ||| ... .. |||||| ||.|||.  |. ||
iskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAHD
|   ..| .|| . .  .||.  ||. |   ||||| . ...
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
0041856 (Phosphotyrosine protein) phosphatases II 295-437 2e-33 110.9 In-house 15-172 (182) alignment 
Range on Protein: 295-437
Range on HMM: 15-172/182.0
RSMPMSQVLSYLFLGSAVD--------------ASNLAALREHRITAILNITtdVPNTFADSL-----QYQQIPILDTSEQNiqnyFEVAFEFINQAKQE
.|....... .|.|||  .              |..|  |.|..||.|.|.|   .. ... |     ||...|. | .  .    .. ...||.....|
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevlee

GRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRS--IISPNLAFMGELKEYEGKL
|..||||| ||..|....|. |||......| .| ..|  .|.  .|.||  |.  |...| .|
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0043147 (Phosphotyrosine protein) phosphatases II 300-437 9.9e-32 105.4 In-house 20-160 (172) alignment 
Range on Protein: 300-437
Range on HMM: 20-160/172.0
SQVLSYLFLGSAVDASNLAALREHRITAILNITTD---VPNTFADSLQYQQIPILDTSEQnIQNYFEVAFEFINQ--AKQEGRNVLVHCQAGISRSAAFV
 ... ......  .|.... |.|. ||.|.|.|.     .. .   .||. .|. | . . . .... ..|||..  |...|  ||||| ||..|....|
drfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

IGYLMYeRNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKL
. |||. ....| .| ..|  .|.....|  ..  |...| .|
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 301-434 3.3e-31 101.8 In-house 10-144 (148) alignment 
Range on Protein: 301-434
Range on HMM: 10-144/148.0
QVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFAD-SLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLM
   ..|||||   |..| ||..  .|.| | | . .|.... ...| .... |  ..... .|| . .|...||.||| ||||.| |.|||.| .. .|.
ikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwli

YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
  ... |..| ..|   |  . ||| |.  | |.|
dfkrvslkealalvkskrryvdpnlgfLkqLaele
PTEN_1 293-438 9.8e-31 102.1 In-house 35-192 (196) alignment 
Range on Protein: 293-438
Range on HMM: 35-192/196.0
ARRSMPMSQVLSYLFLGSAVDA-SNLAALREHRITAILNITTDVPN---------TFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ--EGRNVL
|    .....   |..||. |. ..|  | |. ||...| . . ..          |.  ..| ..|| |   ....  |... .||.....  .|..||
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

VHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLA
|||.||..||.  |. |||| .... ..|  .|  .|. ..|| ... .|.||. .| 
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0049260 (Phosphotyrosine protein) phosphatases II 300-437 1.1e-30 101.7 In-house 9-149 (152) alignment 
Range on Protein: 300-437
Range on HMM: 9-149/152.0
SQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNT---FADSLQYQQIPILDTSEQNIQNYFEVAFEFINQ-AKQEGRNVLVHCQAGISRSAAFVI
 ... ....|.   |...  |.|. ||.|...|......   ..   ||...|. | . ...  ... ...||.. |...| .||||| ||..|....|.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

GYLMYeRNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKL
 |||. ....| .| ..|  .|... ||  ..  |.|.|..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0046846 (Phosphotyrosine protein) phosphatases II 295-436 1.6e-30 101.5 In-house 8-171 (176) alignment 
Range on Protein: 295-436
Range on HMM: 8-171/176.0
RSMPMSQVLSYLFLGSAV----------DASNLAALREHRITAILNITTDV-------PNTFAD----SLQYQQIPILDTSEQNIqNYFEVAFEFINQAK
  ....... .|.|||.            |..|. |.|..|||..|.|..|       || . .    ..||...|. | .  .. .... ..|||..| 
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

QEGRNVLVHCQAGISRSAAFVIGYLMYE-RNMNLNDAHNYVSVCRS-IISPNLAFMGELKEYEGK
.||..|||||.|||.|....|. ||..  .......|  .|  .|.  . .. ...  |.|.| .
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0049772 (Phosphotyrosine protein) phosphatases II 300-437 1.1e-29 99.5 In-house 155-273 (314) alignment 
Range on Protein: 300-437
Range on HMM: 155-273/314.0
SqvlsylflgSAVDASNLAALRehritailnitTDV--PNTFADS-LQYQQIPILDtSEQNIQNYFEVAFEFINQAkQEGRNVLVHCQAGISRSA-AFVI
          .  .|..|. |.           . .  |. | .  ..| .||. |  .... ..|. ..|||..| ..|..|||||.||..|.. . |.
g.........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvva

GYLMYERNMNLNDAHNYVSVCRSiISPNLAFMGELKEYEGKL
.|||. ....|..| ..|  .|. |.||  |.  |..|| .|
aylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 300-436 1.2e-29 96.6 In-house 4-151 (154) alignment 
Range on Protein: 300-436
Range on HMM: 4-151/154.0
SQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADS---------LQYQQIPILDTSEQNIQNYFEVAFEFINQAK--QEGRNVLVHCQAGIS
|.. ..|...|   | |   |....|. |||. . ..| |.|          ..| .. . |  ...| . .. |||||..|    |  .||||...|.|
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGK
||||..|.||| .....|  |   .  .| ||.||  |.  |. .| .
rsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke
0045098 (Phosphotyrosine protein) phosphatases II 289-437 1.4e-29 98.8 In-house 12-271 (278) alignment 
Range on Protein: 289-437
Range on HMM: 12-271/278.0
CQQAARRSMPMSQVLSYLFLGSAV-----------------------------------------DASNLAALREHRITAILNIT---------------
  .  ..  ..|... .|.||..                                           |...  |.|..||.|...|               
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

-------------------------------------TDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ--------------EGRNVLV
                                     .| .. .   |.|  .|  .. ...| ..|  ..|||..| .              .|  |||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCQAGISRSAAFVIGYLMYER---NMNLNDAHNYVSVCRSI-ISPNLAFMGELKEYEGKL
||.||..|....|. |||.|.   ...| .| ...  .| . . .|| ..  | |.. .|
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 300-438 2.2e-29 96.4 In-house 121-259 (263) alignment 
Range on Protein: 300-438
Range on HMM: 121-259/263.0
SQVLSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQI-PILDTSEQNIQNYFEVAFEFINQAKQEGrNVLVHCQAGISRSAAFVIGYL
....  ||||.   | | . |..  .| ||   .|.   | . ..|  |  | |. | .|...||    ||.. ...|  |||||.||.|||.. || ||
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkG.GvlvhcraGvsrsstlvisyl

MYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLA
|  .......| . |   |. | ||  |.  || || || 
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_MKPLT_pd Subfamily MKPLT 303-434 5e-29 94.9 In-house 26-157 (164) alignment 
Range on Protein: 303-434
Range on HMM: 26-157/164.0
LSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYER
   |.|| | .| |   |..  || |.|....  . |. |..|.|. . |.|.... ...| | .|. .| . |  |||||. | |||..  . .|.  .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

NMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
   |..|..|.   |||..||  |. .| ..|
gwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 303-434 5e-29 94.9 In-house 26-157 (164) alignment 
Range on Protein: 303-434
Range on HMM: 26-157/164.0
LSYLFLGSAVDASNLAALREHRITAILNITTDVPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYER
   |.|| | .| |   |..  || |.|....  . |. |..|.|. . |.|.... ...| | .|. .| . |  |||||. | |||..  . .|.  .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

NMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
   |..|..|.   |||..||  |. .| ..|
gwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_DSP3_pd Subfamily DSP3 297-440 5.1e-29 95.0 In-house 9-160 (162) alignment 
Range on Protein: 297-440
Range on HMM: 9-160/162.0
MPMSQVLSYLFLGSAVDASNLAALREHRITAILNITTD----V---PNTFAD-SLQYQQIPILDTSEQNIQNYFEVAFEFINQAK-QEGRNVLVHCQAGI
  . .|   |..| .  |..   |..  || .|| .      |   .. . | ...|  ... |. | ....||| |..||..|  |.   |||||..|.
kevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIiSPNLAFMGELKEYEGKLAHD
||||. |. |||  |.|.|..| . |   |.|  ||  |.  |.|.. .|...
sRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkrk
subfamily_STYXL1_pd Subfamily STYXL1 297-438 3.1e-28 92.0 In-house 10-154 (157) alignment 
Range on Protein: 297-438
Range on HMM: 10-154/157.0
MPMSQVLSYLFLGSAVDASNLAALREHRITAILNITTD---VPNTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAF
 |.  . . |.||   .| | |  .. .. | .|...|   . .. ||  .  .|.. |. | .. . .. | .||.. |.||. |||  . ||||||| 
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaav

VIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLA
.|.||||.....|..|..|.  |.. . || ||.  |.|.| .| 
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0040439 (Phosphotyrosine protein) phosphatases II 295-434 1.5e-27 92.2 In-house 25-242 (249) alignment 
Range on Protein: 295-434
Range on HMM: 25-242/249.0
RSMPMSQVLSYLFLGSAVDASNLAA------------------------LREHRITAILNITTDVPN---------------------------------
.|..  ..|. |||.. ..|| .                          |.|..||.|...|..|..                                 
hsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddy

----------TFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ------EGRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVC
           . .|.....|...|  ....  .|| ...||.....      .|  ||||| ||..|...|.. |||     .|....| .| ...  .
tvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq

RSIISPNLAFMGELKEYE
|. . .|. ..  | |..
Rpgavqnpeqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 299-434 2.9e-27 91.2 In-house 39-238 (243) alignment 
Range on Protein: 299-434
Range on HMM: 39-238/243.0
MSQVLSYLFLGSA--------VDASNLAALREHRITAILNITTDV---------------------------------------------PNTFADSLQY
...|. .|.....        ..||..  | |..||.|...|..|                                             .. .    .|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

QQIPILD----TSEQNIQNYFEVAFEFINQ-----AKQEGRNVLVHCQAGISRSAAFVIGYLMYER-NMNLNDAHNYVSVCRSI-ISPNLAFMGELKEYE
...|. |    .| ........ . |||..     |  .|. ||||| ||..|...... |||... ...| .| ...  .|.  . ... ..  | |..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_STYX_pd Subfamily STYX 298-435 3.6e-27 88.5 In-house 11-155 (166) alignment 
Range on Protein: 298-435
Range on HMM: 11-155/166.0
PMSQVLSYLFLG--SAVDASNLAALREHRITAILNITTDVP-----NTFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRS
 | ..|  ||||  ||   | |  |..| || |. |  ..        | |...|  . . |.. .||  |.    |||... |.| .|||| .||||||
emqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

AAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEG
||.||.|.|    ..  .|. ||   |  |.||  |. .||||| 
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0051082 (Phosphotyrosine protein) phosphatases II 299-433 2.1e-26 87.7 In-house 8-149 (151) alignment 
Range on Protein: 299-433
Range on HMM: 8-149/151.0
MSQVLSYLFLGSAVDASNLAALREHRITAILNITTDV-----PNTFAD-SLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQE-GRNVLVHCQAGISRSA
.|.| ..|.....  | .|. |.|. |..|.|.....     |. . . .... .|||||....... .|. . ||.... .  . .||||| ||..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

AFVIGYLMYeRNMNLNDAHNYVSVCRS-IISPNLAFMGELKEY
..|. |||. ....|..| ...  .|  .. ||  |. .|...
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 298-437 3.1e-26 87.5 In-house 11-169 (174) alignment 
Range on Protein: 298-437
Range on HMM: 11-169/174.0
PMSQVLSYLFLGSAVDAsNLAALREHRITAILNITTDVPNT---------------FADSLQYQQIPILDTSEQNIQNyFEVAFEFINQAKQE--GRNVL
 .| ....|..|..  | ... |.|..||.... .. ...                    .||...|. | .. ...  .. ...|...| .|  |. ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCQAGISRSAAFVIGYLMYERNM-NLNDAHNYVSVCR---SIISPNLAFMGELKEYEGKL
||| ||..|....|. |||. . . .| || ..|  .|   . . ..  ..  | ..| .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0045450 (Phosphotyrosine protein) phosphatases II 318-434 3.5e-25 84.8 In-house 125-300 (307) alignment 
Range on Protein: 318-434
Range on HMM: 125-300/307.0
AALREHRITAILNITTDVPNTF----------------------------ADSLQYQQIPILDT-----------------SEQNIQNYFEVAFEFINQA
  |.|...|.|...|..|....                             |.... .... |.                  ....  .|| ...||...
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

KQ------EGRNVLVHCQAGISRSAAFVIGYLMYERN--------MNLNDAHNYVSVCRSIISPNLAFMGELKEYE
..      .|  ||||| ||..|...|.. |||...         ..| .| ...  .|. . .|. ..  | |..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 297-434 1e-23 79.5 In-house 45-239 (245) alignment 
Range on Protein: 297-434
Range on HMM: 45-239/245.0
MPMSQVLSYLFLGSAVDASNLA----ALREHRITAILNITTDVPNTF----------------------------------------------ADSLQYQ
......   ......  .....     |.|..||.|...|..... .                                                 ..|.
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

QIPILDTSEQNIQNYFEVAFEFINQAKQ--EGRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
..|. | .. .. .... ..||...| .  ..  ||||| ||..|...|.. |||     .|....| .|  ..  .|. . ... ..  | |..
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 319-433 1e-21 73.0 In-house 105-271 (317) alignment 
Range on Protein: 319-433
Range on HMM: 105-271/317.0
ALREHRITAILNITTDVPNT---------------------------FADSLQYQQIPILDT----------------SEQNIQNYFEVAFEFINQAKQE
 . |...| |...|. ...                              .. .. .... |.                 ....  ...  ..|...... 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEY
    |  ||||| ||..|...|.. |||     .|..... .| ...  .|. . ......  | ..
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0039614 (Phosphotyrosine protein) phosphatases II 318-434 1.4e-20 69.4 In-house 119-285 (297) alignment 
Range on Protein: 318-434
Range on HMM: 119-285/297.0
AALREHRITAILNITTDVPNTFaDSL-------------------------------------------QYQQIPILDTSEQNIQNYFEVAFEFINQAKQ
  ..|...|.|...|. |..                                                 ..| ... | .  .. ...  ..|....| .
rmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---EGRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
   .|. ||||| ||..|...|.. |||     .|..... .| ...  .|. . ... ..  | ...
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
subfamily_PTPMT1_pd Subfamily PTPMT1 297-438 1.5e-20 68.3 In-house 32-169 (171) alignment 
Range on Protein: 297-438
Range on HMM: 32-169/171.0
MPMSQVLSYLFLGSAVDAsNLAALREHRITAILNITTDVPNTfadSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIG
.|. .  . |.    | |  ..   |....|. | | .  ..    ... |... |  |.  ..  | . |||.. ...|. | |||.|| .|||. |. 
lPfrslikeLiekenvka.vvslneeyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvac

YLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLA
|||.........|....  .|.||  . . .  |.||| || 
ylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 306-438 2.2e-20 66.2 In-house 6-142 (145) alignment 
Range on Protein: 306-438
Range on HMM: 6-142/145.0
LFLGSAVDASNLAALREHRITAILNITTDVPNTfADSLQYQQIPIL-----DTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMY
|. |||. |.....|.|  |. |.|...    . ...|. ..| ||     |    .. ..|.   .||.. |.||  |.||| ||.||| .  . .|| 
lyvgsalhandvptlqelgisrivnmaagslva.sqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

ERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLA
  || | .|   |   |    ||. |. .| . | .| 
ycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0038934 (Phosphotyrosine protein) phosphatases II 313-440 2.4e-20 68.5 In-house 45-179 (194) alignment 
Range on Protein: 313-440
Range on HMM: 45-179/194.0
DASNLAALREHRITAILNITTDV-----PNTFADSLQYQQIPILD----TSEQNIQNYFEVAFEFINQakQEGRNVLVHCQAGISRSAAFVIGYLMYERN
|  ..  |. .........| .          .  ..| ..|. |     | .......... ||.|.  ..|  |.||| ||..|.. .|. ||.| ..
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlg

MNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAHD
|....| .... .|  . ||  .. .| .. . | ..
msaeeAialfrekRpgaipnqdyleallkrykelrka
0036941 (Phosphotyrosine protein) phosphatases II 313-434 3.8e-20 67.8 In-house 33-273 (297) alignment 
Range on Protein: 313-434
Range on HMM: 33-273/297.0
DASNLA----------------------------------------------------------ALREHRITAILNITTDVPNTFA--------------
 |....                                                           . |...| |...|..|.. .               
vallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesl

---------------------------------DSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ------EGRNVLVHCQAGISRSAAFVIGYLM--
                                 .|.. ... ...  . .. ....  ..||.....      .|  ||||| ||..||..|.. .||  
tygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlq

------YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYE
      .|..... .| ...  .|  . ..| ..  | |..
qledklkeggvdileavkklReqRpgavqtleqyrflyeal
0051429 (Phosphotyrosine protein) phosphatases II 305-434 7.8e-20 67.1 In-house 23-221 (272) alignment 
Range on Protein: 305-434
Range on HMM: 23-221/272.0
YLFLGSAV---DASNLAALREHRITAILNITTDVPNTFAD------SLQYQQIPILDTSEQNIQNYF---------------------------------
.|.....    .| ....|.|..|..|.......   . .       ..| ..||||.|.. |  ..                                 
rlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

---------------EVAFEFINQAKQeGRNVLVHCQAGISRSAAFVIGYLMYeRNMN--------------LNDAHNYVSVCRSIISPNLAFMGELKEY
               |   |....  . |..||||| ||..|.. .|  .|.. ....              | .| ...  .|  . .. ...  | |.
mhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

E
.
l
0043336 (Phosphotyrosine protein) phosphatases II 319-433 3.6e-17 58.2 In-house 107-272 (278) alignment 
Range on Protein: 319-433
Range on HMM: 107-272/278.0
ALREHRITAILNITTDVPNTF---------------------------------------------ADSLQYQQIPILDTSEQ-NIQNYFEVAFEFINQA
 ..|...| |...|..| .                                                  ..|. ... | .   ... ...   ..... 
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

KQEGRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNLAFMGELKEY
. ..  ||||| ||..|...|.. ||.     .|....| .| ...  .|  . ... ..  | |.
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_MSG5_pd Subfamily MSG5 357-439 3.9e-15 49.4 In-house 80-162 (165) alignment 
Range on Protein: 357-439
Range on HMM: 80-162/165.0
NIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGELKEYEGKLAH
.|   .    . |  |. ... .||||| |.||||.... |.|   |. |.||.. .      |||.. .. .| |.|  |..
kivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk
0047943 (Phosphotyrosine protein) phosphatases II 320-426 2e-14 49.2 In-house 97-260 (273) alignment 
Range on Protein: 320-426
Range on HMM: 97-260/273.0
LREHRITAILNITTDVPN----------------------------------------------TFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAK
. |.... |  .|..| .                                               . .|......  ..  ....  ..|  .|||....
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

Q------EGRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNLAF
.      ..  |.||| ||..|...|.. .|.     .|..... .| ...  .|  . ... .
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 322-424 3.2e-14 48.5 In-house 114-272 (288) alignment 
Range on Protein: 322-424
Range on HMM: 114-272/288.0
EHRITAILNITTDVPN-----------------------------------------------TFADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ
|.... |  .|. | .                                                   |......  ..  .... ...|  ..|......
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

E----GRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISPNL
     |  |.||| ||..|...|.. .|.     .|. ... .| ...  .|  . ...
alasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 321-422 1.4e-12 43.0 In-house 129-283 (308) alignment 
Range on Protein: 321-422
Range on HMM: 129-283/308.0
REHRITAILNITTDVPNT----------------------------------------------FADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQ
 |.... |  .|. | |                                                 .|......  ..  .... ...|  ..|......
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

E--GRNVLVHCQAGISRSAAFVIGYLM-----YERNMNLNDAHNYVSVCRSIISP
   | ...||| ||..|...|.. .|.     .|..... .| ...  .|    .
slpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
Rhodanese Rhodanese-like domain 14-132 2.4e-12 39.4 Pfam-A 3-112 (113) alignment 
Range on Protein: 14-132
Range on HMM: 3-112/113.0
DDLASMLtSQSAVCIIDVRSFDCYARRHIRSALSIRCSNIhlrRLNKGLMDLVDILNDTEKRWAKRSPDDWVVVYDdhasfpgETTFDGNNVLHV-VLRG
..|...|  .. | ..||||.. ||. ||. |.... ...   . .. |..  .. .. |... | ..|. ||||.       ... ..... .. .   
kelkell.ekekvvllDvRspeeyakghIpgAvnvpldsl...yprrdlffkdklaeeleesgkkldkdktvvvyc.......rsgnrsggaaalllali

LQQ-KHINCAFLHGGFTAFEA
|..  . |. .| |||.|. |
lkelgyknvyvLdGGfeawka
0046845 (Phosphotyrosine protein) phosphatases II 322-419 1.4e-11 39.7 In-house 99-255 (284) alignment 
Range on Protein: 322-419
Range on HMM: 99-255/284.0
EHRITAILNITTDVPNT---------------------------------------------FADSLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQE-
|.... |  .|. | |                                                 |.. ... ...  ....  ..|  .||......  
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----GRNVLVHCQAGISRSAAFVIGYLMYER--------NMNLNDAHNYVSVCRSI
     |  ..||| ||..|...|.. .|..|.        .... .| ...  .|  
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
subfamily_Laforin_pd Subfamily Laforin 342-417 1.6e-09 30.9 In-house 76-151 (183) alignment 
Range on Protein: 342-417
Range on HMM: 76-151/183.0
SLQYQQIPILDTSEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCR
 | |  .|. | | ..  . .  |  ..    ..|  | |||.||. ||.| | |.|.|  . .|.    ..   |
glayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
PTPc_DSPc_SM00012 343-407 3.2e-09 32.3 In-house 5-70 (105) alignment 
Range on Protein: 343-407
Range on HMM: 5-70/105.0
LQYQQIPILDTSE--QNIQNYFEVAFEFINQAKQeGRNVLVHCQAGISRSAAFVIGYLMYERNMNLN
..| ..|   . |  ..| ....   .. |.... . .|.|||.||..|.. ||  ......... .
yhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket
0048567 (Phosphotyrosine protein) phosphatases II 357-420 3.1e-08 28.1 In-house 55-123 (157) alignment 
Range on Protein: 357-420
Range on HMM: 55-123/157.0
NIQNYFEVAFEFINQAKQEGRNVLVHCQAGI---SRSAAFVIGYLMYERNMNLNDAHNYVSVCR--SII
 . ... .. .|... . .|. . ||| ||    .|.| ..  ||..  ... ..| ......|  |..
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_CDC14_pd Subfamily CDC14 367-428 1.5e-07 25.6 In-house 254-317 (328) alignment 
Range on Protein: 367-428
Range on HMM: 254-317/328.0
EFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCR--SIISPNLAFMG
.|.. |..   .. |||.||. |  ...  |||.. ... ..|  .. .||  |.|.|   |. 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfle
subfamily_RNGTT_pd Subfamily RNGTT 354-430 2.4e-07 24.6 In-house 93-167 (189) alignment 
Range on Protein: 354-430
Range on HMM: 93-167/189.0
SEQNIQNYFEVAFEFINqaKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIISPNLAFMGEL
........ ..  ||..  |.  . . |||. |  |.  ... ||. ........| .  . .|     .  .. ||
eaeqvkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 354-421 2.5e-07 25.1 In-house 169-236 (290) alignment 
Range on Protein: 354-421
Range on HMM: 169-236/290.0
SEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSIIS
.. |.|.   .. . |.. |...  |.|||. |||||||.    | |   ...... . ..|  .. .
nklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk
subfamily_DSP11_pd Subfamily DSP11 354-419 4.2e-07 24.0 In-house 94-159 (178) alignment 
Range on Protein: 354-419
Range on HMM: 94-159/178.0
SEQNIQNYFEVAFEFINQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVSVCRSI
.|. .... |.  ||... |.... . |||  |. |.  ..  ||.   ... .|| .  . .|  
keelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGh
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 370-406 1.2e-06 22.8 In-house 142-181 (255) alignment 
Range on Protein: 370-406
Range on HMM: 142-181/255.0
NQAKQEGRNVLVHCQAGISRSAAFVIGYLMYERN---MNL
 .. .. . |.|||..|| ||||||.  |.| .    .. 
lkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldt
Y_phosphatase Protein-tyrosine phosphatase 353-418 1.3e-06 23.4 Pfam-A 143-211 (235) alignment 
Range on Protein: 353-418
Range on HMM: 143-211/235.0
TSEQNIQNYFEVAFEFINQAKQEG----RNVLVHCQAGISRSAAFVIGYLMYERNMNlNDAHNYVSVCRS
  ......  .  ...|.. ...      .|.||| ||..|.. ||   .. |.  . ..  . ......
WpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivke
Y_phosphatase Protein-tyrosine phosphatase 353-418 1.3e-06 23.4 In-house 143-211 (235) alignment 
Range on Protein: 353-418
Range on HMM: 143-211/235.0
TSEQNIQNYFEVAFEFINQAKQEG----RNVLVHCQAGISRSAAFVIGYLMYERNMNlNDAHNYVSVCRS
  ......  .  ...|.. ...      .|.||| ||..|.. ||   .. |.  . ..  . ......
WpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivke
subfamily_PTPDC1_pd Subfamily PTPDC1 343-414 1.4e-06 22.8 In-house 83-152 (182) alignment 
Range on Protein: 343-414
Range on HMM: 83-152/182.0
LQYQQIPILDTSEQNIQNYFEVAfEFINQAKQEGrNVLVHCQAGISRSAAFVIGYLMYERNMNLNDAHNYVS
. . .... | . . ... ...    ...| ||| .| ||| ||  |    .  ||.| .... ..| . | 
iyvynfgwkDygvasleriLdiv.kvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvr
DSPc_SM00195 344-401 3.1e-06 22.1 In-house 159-220 (263) alignment 
Range on Protein: 344-401
Range on HMM: 159-220/263.0
QYQQIPILDTSEQNIQNYFEVAFEFINQAKQE----GRNVLVHCQAGISRSAAFVIGYLMYE
. .|. . .  ......  .  .|.....|..       ..|||.||..|...||   ....
kvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
PTPc_SM00194 344-401 3.1e-06 22.1 In-house 159-220 (263) alignment 
Range on Protein: 344-401
Range on HMM: 159-220/263.0
QYQQIPILDTSEQNIQNYFEVAFEFINQAKQE----GRNVLVHCQAGISRSAAFVIGYLMYE
. .|. . .  ......  .  .|.....|..       ..|||.||..|...||   ....
kvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiils
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 318-431 3.5e-06 17.3 Pfam-A 312-433 (451) alignment 
Range on Protein: 318-431
Range on HMM: 312-433/451.0
AALREHRITAILNITTDVPN--TFADSLQYQ--QIPILDTSEQNIQNYFEVAFEFINQAKQE--GRNVLVHCQAG--ISRSAAFVIGYLMYERNMNLNDA
 | .|..........  . .  |  .. ..   ..    ........ .. . |||..  ..   ...||.|. |  .| .....|  |... ...|.  
vakeekevdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkks

HNYVSVCRSIISPNLAFMGELK
..  .. ...|  .||.. | |
eeekkinkelirkrlalliesk