Gene DSP12 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP011_AA protein Get Run
MbreP011_AA_0-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 1-157 1.2e-56 185.4 In-house 2-154 (155) alignment 
Range on Protein: 1-157
Range on HMM: 2-154/155.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSwywFGHRLLPSTVRrQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.||...|||.|.|| .|...|. ||....... ....    . |.| ...|. .|.| ..||...||||.|.||.||||.|..|.| |.||||||||||.
vsrilpglylggleavqeeellkelkithvlsvikeel...pehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKCTLDDSNPDYR
|.|.||||.. .|...||....|.... . || ||..||.|||||.|..|.||..|.
tiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayk
subfamily_DSP19_pd Subfamily DSP19 3-146 1.2e-37 123.5 In-house 14-150 (152) alignment 
Range on Protein: 3-146
Range on HMM: 14-150/152.0
RVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllPSTVrRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
 | . ||.|| .  .|.  . | ..  |   |      .      |. .   .|| ..|....|.||.|.|||||||.|||.||.|.|||.|||||||.|
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvf......pkdf.tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
|.||||..  |....|......|.... || ||..||. .|. .
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
PTPc_motif_SM00404 1-145 4e-31 102.8 In-house 2-140 (140) alignment 
Range on Protein: 1-145
Range on HMM: 2-140/140.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwfghrllpS--TVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSR
.||. ..||.||..  |. ||. .||.. .   .   |.         .    .. ..| . |.|..... .|...|||||.|... | |.|||||||||
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSR

SATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|||...|||||  .|. ..|....|       || .| .||  .||.
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0044763 (Phosphotyrosine protein) phosphatases II 1-148 9.3e-31 102.2 In-house 23-172 (178) alignment 
Range on Protein: 1-148
Range on HMM: 23-172/178.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWFGH--RLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESAR-SEDGIVYVHCQAGVS
.|....|||.|||   .| .|. |||...|   ..   .. ...    . ..  . . | . |    |.|....|...|||.|. ...| |.|||.|||.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSATVVMAYLMRNLGLNCSKAFRMLKAAHRpALPNPGFQQQLRLFEKMKCT
||.|.|.||||. |||.  .|....... . . ||||...||..||.. . 
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP1_pd Subfamily DSP1 3-146 1.7e-28 93.8 In-house 20-156 (163) alignment 
Range on Protein: 3-146
Range on HMM: 20-156/163.0
RVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwFGHrllpstVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
.. | ||.|| .   .  .. .||.. |   ... . . | .      . . |.. . |...||| ... |...||.......| |..|||||.|||.|.
kildfLylGsetvasnleiLkslgitailnvskeldnv.fed......lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
..||||..  .. ..|| . |       || ||..||  .||  
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0048076 (Phosphotyrosine protein) phosphatases II 1-145 2.1e-28 94.2 In-house 4-141 (145) alignment 
Range on Protein: 1-145
Range on HMM: 4-141/145.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllpSTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|....|||.|||   .| .|. .||.  .   .. ....         .. .   . . | .  |.|..|.|.|.|||.|..|.| |.|||.|||.|..
pseilpglylgslptaldlellkdlgittvlnltselelle.......rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|.|.||||. ||..  .|......... | ||||....|..||..
tlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 1-144 2.2e-28 94.1 In-house 4-142 (144) alignment 
Range on Protein: 1-144
Range on HMM: 4-142/144.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWFGHRllpstVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|....|||.|||  ..| .|. .||.. .   .. . ......      . .   . . | .  |.|..|.|.|.|||.|..|.| |.|||.|||.|..
pseilpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.|.||||. |||.  .|........  | ||||. ..|...||
tlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
DSPc Dual specificity phosphatase, catalytic domain 51-144 4.6e-28 92.7 Pfam-A 39-132 (133) alignment 
Range on Protein: 51-144
Range on HMM: 39-132/133.0
VRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 ... .| | ||....| ..|.|| .|||.|... . |.||||||.|||||...||||.  .|. ..|....|       || ||..||. .|.
eieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 51-144 4.6e-28 92.7 In-house 39-132 (133) alignment 
Range on Protein: 51-144
Range on HMM: 39-132/133.0
VRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 ... .| | ||....| ..|.|| .|||.|... . |.||||||.|||||...||||.  .|. ..|....|       || ||..||. .|.
eieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 1-147 1.7e-26 87.1 In-house 2-140 (151) alignment 
Range on Protein: 1-147
Range on HMM: 2-140/151.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHrrswywFGHRLLPStvRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|.|  |||.| ..  .|..|..|  .. |             ..||.    . | | . |  .|.. ... |. .|| ..|.... |.||| ||||||.
iskvlpglylgnfrdskdeelLkeknithilsvhd......nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKC
|.|.||||  . ||  .|....|||   | || ||..||. .||.| 
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl
0049772 (Phosphotyrosine protein) phosphatases II 49-146 2e-26 88.9 In-house 178-273 (314) alignment 
Range on Protein: 49-146
Range on HMM: 178-273/314.0
STVRRQKSILVFDeEQADILSWLPEALDFIESArSEDGIVYVHCQAGVSRSAT-VVMAYLMRNLGLNCSKAFRMLKAAHRpALPNPGFQQQLRLFEKMK
 .. . . | | | ..|..|....|.|.|||.| ...| |.|||.||..|..| ||.||||. ||..  .|........  . ||||| .||...|.. 
rlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_DSP6_pd Subfamily DSP6 53-145 2.4e-25 82.9 In-house 61-153 (158) alignment 
Range on Protein: 53-145
Range on HMM: 61-153/158.0
RQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. . | . |. .... ...|||..||. |||..  | ||| ||.||| ||..||||..| |   .|. ..|. .    ||  | .||  ||..
kylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_DSP14_pd Subfamily DSP14 54-144 6.5e-25 81.9 In-house 52-142 (157) alignment 
Range on Protein: 54-144
Range on HMM: 52-142/157.0
QKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.  . | |...|.. ... |. | ||... ..| . ||| |||||||....||||.   |.  .|....|.|     || || .||. .||
rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
0043147 (Phosphotyrosine protein) phosphatases II 47-149 1.4e-24 82.2 In-house 61-163 (172) alignment 
Range on Protein: 47-149
Range on HMM: 61-163/172.0
LPSTVRRQKSILVFDEEQAdILSWLPEALDFIES--ARSEDGIVYVHCQAGVSRSATVVMAYLMRnLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|  .. .   . . |     .|..|.|.|.||..  |.|..| |.||| |||.|..|.|.||||. |||.  .|....... . | .||.....|. |||
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek

MKCTL
.  .|
lllll
PTEN_1 4-145 6.4e-24 79.9 In-house 44-190 (196) alignment 
Range on Protein: 4-145
Range on HMM: 44-190/196.0
VDDGLYIGSLELL-QDHALMGELGVSSIAGSAHRRSWywFGHRLLPST--VRR--QKSILVFDEEQADILSWLPEALDFIESARS--EDGIVYVHCQAGV
.|.|||.|||... .|   ..| |. ..   ....     | .  ...   ..  .... . |    .. ... .. .|||...|  . ..|.|||.||.
ideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGl

SRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.||.|||.||||.  .|.  .|.......  |. ||...|..|. ....
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_DSP8_pd Subfamily DSP8 4-144 7.2e-24 78.1 In-house 18-152 (159) alignment 
Range on Protein: 4-144
Range on HMM: 18-152/159.0
VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWywfgHRLLPSTVrrQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVV
. . ||.|| .   .. |. .||.| .  . .           |. .      . | |. . ..| |......||. |.||.| | ||. || ||||||.
ilknlylGsqkdvlseellsklgisyvlnasnscpk....leelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

MAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.||.|..| ..  .|.| .|       ||  |..||  .||
iayimktlemsldeayrfvkekrptispnlnflgqLleyek
subfamily_DSP10_pd Subfamily DSP10 54-144 9.1e-24 78.1 In-house 61-151 (159) alignment 
Range on Protein: 54-144
Range on HMM: 61-151/159.0
QKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 | | | | .. ..     |||.||| ||...  | ||||||.|||||||.||||..|.|. ..|... | .     || .|  ||  |||
YkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
0041856 (Phosphotyrosine protein) phosphatases II 2-149 4.7e-23 77.1 In-house 20-175 (182) alignment 
Range on Protein: 2-149
Range on HMM: 20-175/182.0
SRVDDGLYIGSLEL--------------LQDHALMGELGVSSIAGSAhrRSWYWFghRLLPSTVRRQKSILVFDEEQADilswLPEALDFIESARSEDGI
... ..||.|||                 ..  .. |||...|   .     ||    ||. .. . . . . | .  |    |.|.||||| ...|.| 
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywp..ellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHR--PALPNPGFQQQLRLFEKMKCTL
|.||| |||.|..|.|.||||. ||..  .|..... .       || .|  || |.|....  
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP3_pd Subfamily DSP3 4-143 5.5e-23 75.4 In-house 14-154 (162) alignment 
Range on Protein: 4-143
Range on HMM: 14-154/162.0
VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRrSW--YWFGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSA
| ..||.|  .  .|.  . .||.  .  .|.  ..     |.     .  .   . | |  ..|.  .  .| .||..| |. .| |.|||..||||||
vypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVVMAYLMRNLGLNCSKAFRMLKaAHRPALPNPGFQQQLRLFE
|.|.||||    ..  .| |  . ..|  ||| || .||. ..
tlvlayLmirrkmtlveairtvr.kkReilPneGFlkqLaeld
subfamily_Slingshot_pd Subfamily Slingshot 55-145 8.7e-23 74.5 In-house 66-156 (169) alignment 
Range on Protein: 55-145
Range on HMM: 66-156/169.0
KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. | |.|||..|.|..  |. .||| |....  | |||. ||||||..|.|| |.. ||.  .|.. .|   . . ||.|| .||. .| .
lnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
0046846 (Phosphotyrosine protein) phosphatases II 2-145 7.4e-22 73.4 In-house 13-171 (176) alignment 
Range on Protein: 2-145
Range on HMM: 13-171/176.0
SRVDDGLYIGSLE----------LLQDHALMGELGVSSIAGSAHRRSWYWFGHRLLPSTVR----RQKSILVFDEEQADIlSWLPEALDFIESARSEDGI
......|..||.           | .. ... |||.. .     ..   ...   ... ..    . . . . |    |. ..|.|.|.||..|..|.| 
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VYVHCQAGVSRSATVVMAYLMRN-LGLNCSKAFRMLKAAHR-PALPNPGFQQQLRLFEKM
|.|||.||..|..|.|.|||..   ||.  .|...... ..  |...|.. ..|. ||..
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0036282 (Phosphotyrosine protein) phosphatases II 2-145 2.3e-21 71.7 In-house 13-168 (174) alignment 
Range on Protein: 2-145
Range on HMM: 13-168/174.0
SRVDDGLYIGSLELLqDHALMGELGVSSIAGSAHRRSW-------YW-FGHRLLPSTVRRQKSILVFDEEQADILSwLPEALDFIESARSE--DGIVYVH
|.. ..|..|.  |  . ... |||....    . . .       ||   .  |  .. . . . . | .  |.   | |...|.|.|.||  .| |.||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CQAGVSRSATVVMAYLMRNLGL-NCSKAFRMLKAAH---RPALPNPGFQQQLRLFEKM
| |||.|..|.|.||||  ..| .  .|........    .. ..|.. ..|. |||.
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 4-144 4e-21 69.3 In-house 123-256 (263) alignment 
Range on Protein: 4-144
Range on HMM: 123-256/263.0
VDDGLYIGSLELLQDHALMGELGVSSI-AGSAHRRSWYwfghrllPSTVRRQkSI-LVFDEEQADILSWLPEALDFIESARSEDGiVYVHCQAGVSRSAT
. |.|..|.|.  ...... .|||. |    |. .  .       | . .   ||  . | ..|||  .. |   |||. | . | | |||.||||||.|
iidklflGgldsannksilkdlgvthillavadfePlf.......Pklfkyl.siddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsst

VVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.|..|||..  |.  .|. . .       |||||..||. .||
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0049260 (Phosphotyrosine protein) phosphatases II 48-145 5.9e-21 70.2 In-house 55-148 (152) alignment 
Range on Protein: 48-145
Range on HMM: 55-148/152.0
PstvrRQKSILVFDEEQADILSWLPEALDFIES-ARSEDGIVYVHCQAGVSRSATVVMAYLMRnLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.    . . . . |    |.  .|...|.|||  |....| |.||| |||.|..|.|.||||. ||..  .|.......   | ||||. ..|  |||.
i....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 57-145 2e-20 66.7 In-house 61-151 (154) alignment 
Range on Protein: 57-145
Range on HMM: 61-151/154.0
ILVFDEEQADILSWLPEALDFIESAR--SEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. .||. . ||.  |  |..||..|    |.. | ||...||||||.....||| .| .. |.|. .|| .     || || .||  ||| 
lelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke
0037934 (Phosphotyrosine protein) phosphatases II 5-144 2.8e-20 68.3 In-house 43-239 (243) alignment 
Range on Protein: 5-144
Range on HMM: 43-239/243.0
DDGLYIGSL--------ELLQDHALMGELGVSSIA-------GSAHRRSWYW-------------------------------FGHRLLPSTVRRQKSIL
 ..|.....         | ..  .. |||...|         ..    .||                                ..  |. .|..   . 
tprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

VFD----EEQADILSWLPEALDFIES-----ARSEDGIVYVHCQAGVSRSATVVMAYLMRNL-GLNCSKAFRMLKAAHRP-ALPNPGFQQQLRLFEK
. |    .. .|.|..| |. .|||.     |....| |.||| |||.|..|...||||  | |..  .|...|..     | ..|.. ..|. ...
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 59-145 3.1e-20 68.2 In-house 166-270 (278) alignment 
Range on Protein: 59-145
Range on HMM: 166-270/278.0
VFDEEQADILSWLPEALDFIESARS--------------EDGIVYVHCQAGVSRSATVVMAYLMRNL---GLNCSKAFRMLKAAHRP-ALPNPGFQQQLR
 ..    .||... |.|.||..|..              ..| |.|||.|||.|..|.|.||||. |   |..  .|...|.   .  |..|......| 
dhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly

LFEKM
 |. .
eflle
0040439 (Phosphotyrosine protein) phosphatases II 51-145 7e-20 67.1 In-house 139-244 (249) alignment 
Range on Protein: 51-145
Range on HMM: 139-244/249.0
VRRQKSILVFDEEQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
.|. . | ..|    .. ......||||| .|.      ..| |.||| |||.|..|...||||     ..||..   |...|. . . | .||.. ..|
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

RLFEKM
  ....
yealle
0045450 (Phosphotyrosine protein) phosphatases II 63-145 5.8e-19 64.4 In-house 206-302 (307) alignment 
Range on Protein: 63-145
Range on HMM: 206-302/307.0
EQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLMRNLG--------LNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
   .. ... |.||||| .|.      ..| |.||| |||.|..|...||||  ..        ..  .|...|..    | .||.. ..|. ....
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 59-144 2.2e-18 62.0 In-house 148-240 (245) alignment 
Range on Protein: 59-144
Range on HMM: 148-240/245.0
VFDEEQADILSWLPEALDFIESARS--EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
. |   .|.|..| ..|.|...|..  ..| |.||| |||.|..|...||||     ..||..  .|...|.   . | ..|.. ..|. ...
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_STYXL1_pd Subfamily STYXL1 55-146 5.9e-18 58.6 In-house 62-153 (157) alignment 
Range on Protein: 55-146
Range on HMM: 62-153/157.0
KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
  | | ||..||.|. | || .|||. . |. .| |  . |.||||.|..|||| .  ..  ||.  ||  .    || .| .||. .||. 
lhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0039614 (Phosphotyrosine protein) phosphatases II 61-145 6.8e-18 60.6 In-house 195-287 (297) alignment 
Range on Protein: 61-145
Range on HMM: 195-287/297.0
DEEQADILSWLPEALDFIESARS---EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|    ..|. | |.|.....|..   ..| |.||| |||.|..|...||||     .. |..  .|...|. . . | ..|.. ..|. ....
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0038934 (Phosphotyrosine protein) phosphatases II 55-146 8.7e-18 60.1 In-house 83-176 (194) alignment 
Range on Protein: 55-146
Range on HMM: 83-176/194.0
KSILVFDEEQADILSWLPEALDFIES--ARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
 .. . |   .  |. | . ||...   .....|.|.||| ||..|..|.| |||.  ||..  .| .... . ..|.||... ..|. . |. 
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0051082 (Phosphotyrosine protein) phosphatases II 2-140 1.7e-17 58.9 In-house 9-147 (151) alignment 
Range on Protein: 2-140
Range on HMM: 9-147/151.0
SRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwFGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSA
|.|..|||...  | .. .|. |||...|        .. . ...||.. .. . | ..|    ..  .....|.|.| ...  .| |.||| ||..|..
syvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TVVMAYLMRnLGLNCSKAFRMLKAAHR-PALPNPGFQQQLR
|.|..|||  ||..  .|...... .     || .|. ||.
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_MKPLT_pd Subfamily MKPLT 59-146 3.4e-17 56.4 In-house 73-160 (164) alignment 
Range on Protein: 59-146
Range on HMM: 73-160/164.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
| || .  . |.|  | .|. .|    | |.|||. |.|||..| .|.|..  |    .|.  ||     . || || .||  ||.. 
vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 59-146 3.4e-17 56.4 In-house 73-160 (164) alignment 
Range on Protein: 59-146
Range on HMM: 73-160/164.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
| || .  . |.|  | .|. .|    | |.|||. |.|||..| .|.|..  |    .|.  ||     . || || .||  ||.. 
vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeeli
0040438 (Phosphotyrosine protein) phosphatases II 64-147 3.7e-17 58.0 In-house 184-276 (317) alignment 
Range on Protein: 64-147
Range on HMM: 184-276/317.0
QADILSWLPEALDFIESARSE----DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKC
  .. ... . |||.| .|.     .| | ||| |||.|..|...||||     .. |..  .|...|... . | ..|.. ..|  .. . .
dhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_STYX_pd Subfamily STYX 59-145 4.6e-17 55.6 In-house 70-156 (166) alignment 
Range on Protein: 59-145
Range on HMM: 70-156/166.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
| |.   .|. .||.  .||... .. | | || .||.||||..|.||.|   ||.  .||....       || || .||. .| .
vadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0036941 (Phosphotyrosine protein) phosphatases II 60-145 1.8e-16 55.7 In-house 176-275 (297) alignment 
Range on Protein: 60-145
Range on HMM: 176-275/297.0
FDEEQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM--------RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
..    .. ..  . ||||| .|.      ..| |.||| |||.||.|...|.||        .. |..  .|...|.     | ..... ..|. .. .
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 8-144 2.8e-16 52.9 In-house 6-139 (145) alignment 
Range on Protein: 8-144
Range on HMM: 6-139/145.0
LYIGSLELLQDHALMGELGVSSIAGSAHRRSWywfGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYL
||.||    .| ... |||.| |   |   .      . | |       |   | |  |.   . |  |||.  . |   |.||| |||||| || .|.|
lyvgsalhandvptlqelgisrivnmaagslv...asqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvafl

MRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.  ..  |.| | ...    | ||  | ..|  .||
mkycnmtlseaarqvrsnrllaypnvtflknllnlek
subfamily_PTPMT1_pd Subfamily PTPMT1 62-144 7.7e-16 53.0 In-house 84-166 (171) alignment 
Range on Protein: 62-144
Range on HMM: 84-166/171.0
EEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
  .|  |  | ....|||. .|.   |||||.|| .||||.| .||| .  |.  .| ..||.  .  . .   ...|. .|.
fteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 7-144 6.4e-15 49.0 In-house 14-145 (148) alignment 
Range on Protein: 7-144
Range on HMM: 14-145/148.0
GLYIGSLELLQDHALMGELGVSSIAGSAHrRSWYWFGHRllpsTVRRQkSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAY
 |..|| .   |   . .|||. |   ..      . .|    ...    . . |... |. .  ... .|.. |..| . | ||.| |||||. .....
fLFlGskksaadlealkalgvtrivnatk.erdnaldqr....gieYl.hvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallw

LMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|..       .|. . | . |   ||.|| .||  .|.
lidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0051429 (Phosphotyrosine protein) phosphatases II 53-165 2e-14 49.4 In-house 71-244 (272) alignment 
Range on Protein: 53-165
Range on HMM: 71-244/272.0
RQKSILVFDEEQADILSWL------------------------------------------------PEALDFIESARSeDGIVYVHCQAGVSRSATVVM
|   . ..|..  .|| .                                                  . |...|  .. .| |.||| ||..|..|||.
rylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvva

AYLMRnLGLN--------------CSKAFRMLKAAHRPALPNPGFQQQLRLFE-KMKCTLDDSNPDYRLYRLEHLT
..|.  ||..                .| ..|.|. . | ..... ..|. .. .. ..| .....| |. |... 
lllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
0043336 (Phosphotyrosine protein) phosphatases II 71-144 6e-14 47.6 In-house 196-274 (278) alignment 
Range on Protein: 71-144
Range on HMM: 196-274/278.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|    ...|  ....| |.||| |||.|..|....||.     ...|..  .|...|.     |...| . ..|. ...
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_MSG5_pd Subfamily MSG5 64-145 1.2e-13 44.5 In-house 78-159 (165) alignment 
Range on Protein: 64-145
Range on HMM: 78-159/165.0
QADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.. |   |..    | .|.|.   . |||| |.||||....||.|.  .|   .|. .||.      |. |.  ||  .| .
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
0047943 (Phosphotyrosine protein) phosphatases II 70-139 4.3e-12 41.5 In-house 184-264 (273) alignment 
Range on Protein: 70-139
Range on HMM: 184-264/273.0
WLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
 | . |.||| .|.      ..| |.||| |||.|..|.....|.     .. |..  .|...|.     . ..| . ..|
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 66-132 9.9e-11 37.1 In-house 196-271 (288) alignment 
Range on Protein: 66-132
Range on HMM: 196-271/288.0
DILSWLPEALDFIESARSE----DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPN
.. . . . |||.. .|.     .| |.||| |||.|..|.....|.     .. |..  .|...|.     . ..
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 71-129 1.8e-10 36.1 In-house 216-281 (308) alignment 
Range on Protein: 71-129
Range on HMM: 216-281/308.0
LPEALDFIESARSE--DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPA
. . |||.| .|.   .| ..||| |||.|..|.....|.     .. |..  .|...|.     .
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
0048567 (Phosphotyrosine protein) phosphatases II 66-142 5.7e-10 33.8 In-house 55-134 (157) alignment 
Range on Protein: 66-142
Range on HMM: 55-134/157.0
DILSWLPEALDFIESARSEDGIVYVHCQAGV---SRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLF
 . ..   . .|... . ... ..||| ||    .|.||.. .||.  ||.. ..|...|. .. . .| .  .. |.|.
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllsly
0046845 (Phosphotyrosine protein) phosphatases II 73-128 8.3e-10 34.0 In-house 186-255 (284) alignment 
Range on Protein: 73-128
Range on HMM: 186-255/284.0
EALDFIESAR------SEDGIVYVHCQAGVSRSATVVMAYLMRNL--------GLNCSKAFRMLKAAHRP
  |.|.. .|      . .| . ||| |||.|..|.....|. ..        |..  .|...|.     
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
subfamily_Laforin_pd Subfamily Laforin 69-129 1.2e-08 28.0 In-house 94-153 (183) alignment 
Range on Protein: 69-129
Range on HMM: 94-153/183.0
SWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLkAAHRPA
  ||.|. .. .   .  ||||||.||| ||...|  .|.  || . .|   .|  |.||.
enlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl.lakrpv
subfamily_CDC14_pd Subfamily CDC14 76-128 3.9e-07 24.2 In-house 254-305 (328) alignment 
Range on Protein: 76-128
Range on HMM: 254-305/328.0
DFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRP
 |.| | . .| . |||.||. |  |.. .|||.. ... . |   |. . ||
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric.rP
PTPc_DSPc_SM00012 72-111 4.1e-07 25.5 In-house 27-65 (105) alignment 
Range on Protein: 72-111
Range on HMM: 27-65/105.0
PEALDFIESARSeDGIVYVHCQAGVSRSATVVMAYLMRNL
 .  .. . . |  . | |||.|||.|..|.|..... . 
ravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq
subfamily_DSP11_pd Subfamily DSP11 72-126 1.3e-06 22.4 In-house 103-157 (178) alignment 
Range on Protein: 72-126
Range on HMM: 103-157/178.0
PEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAH
 .  .|.|.   .| .. |||  || |.  ..  ||.   |.. ..| .... | 
eavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 71-119 4e-06 19.6 In-house 52-100 (128) alignment 
Range on Protein: 71-119
Range on HMM: 52-100/128.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
...  . . | |    ..||||. |. |.  |. .| |. .| .  ||.
irdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 71-119 4e-06 19.6 In-house 51-99 (128) alignment 
Range on Protein: 71-119
Range on HMM: 51-99/128.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
...  . . | |    ..||||. |. |.  |. .| |. .| .  ||.
irdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal
subfamily_PTEN_pd Subfamily PTEN 73-116 7.7e-06 21.0 In-house 100-145 (184) alignment 
Range on Protein: 73-116
Range on HMM: 100-145/184.0
EALDFIESA--RSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCS
|... ||.   .... .| |||.||  |. ....|||. .| |. .
eivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka